

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.44134983 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.43086130 |
| 3 | layer formation in cerebral cortex (GO:0021819) | 5.28956546 |
| 4 | synaptic vesicle exocytosis (GO:0016079) | 5.25558845 |
| 5 | cell migration in hindbrain (GO:0021535) | 5.14534253 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.08772766 |
| 7 | protein localization to synapse (GO:0035418) | 5.05107664 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 5.02989648 |
| 9 | glutamate secretion (GO:0014047) | 4.96916847 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.92810870 |
| 11 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.84765237 |
| 12 | locomotory exploration behavior (GO:0035641) | 4.83575172 |
| 13 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.70476848 |
| 14 | vocalization behavior (GO:0071625) | 4.69623802 |
| 15 | negative regulation of microtubule polymerization (GO:0031115) | 4.64202332 |
| 16 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.50305481 |
| 17 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.48164823 |
| 18 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.43571447 |
| 19 | exploration behavior (GO:0035640) | 4.37252256 |
| 20 | proline transport (GO:0015824) | 4.32161490 |
| 21 | neuron recognition (GO:0008038) | 4.25854182 |
| 22 | neuronal action potential propagation (GO:0019227) | 4.18729881 |
| 23 | regulation of synapse structural plasticity (GO:0051823) | 4.17350558 |
| 24 | regulation of synaptic vesicle transport (GO:1902803) | 4.13913723 |
| 25 | axonal fasciculation (GO:0007413) | 4.13754036 |
| 26 | dendritic spine morphogenesis (GO:0060997) | 3.95065416 |
| 27 | nucleobase catabolic process (GO:0046113) | 3.93254428 |
| 28 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.86336327 |
| 29 | dendrite morphogenesis (GO:0048813) | 3.85778205 |
| 30 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.77642881 |
| 31 | neurotransmitter secretion (GO:0007269) | 3.73326283 |
| 32 | innervation (GO:0060384) | 3.65169285 |
| 33 | synaptic transmission, glutamatergic (GO:0035249) | 3.64180766 |
| 34 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.63763839 |
| 35 | postsynaptic membrane organization (GO:0001941) | 3.62812615 |
| 36 | axon extension (GO:0048675) | 3.54805573 |
| 37 | glutamate receptor signaling pathway (GO:0007215) | 3.52950666 |
| 38 | activation of protein kinase A activity (GO:0034199) | 3.52421819 |
| 39 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.49898732 |
| 40 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.38332547 |
| 41 | neuron-neuron synaptic transmission (GO:0007270) | 3.35951217 |
| 42 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.34185039 |
| 43 | positive regulation of synapse maturation (GO:0090129) | 3.29041327 |
| 44 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.28248770 |
| 45 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.26930209 |
| 46 | mechanosensory behavior (GO:0007638) | 3.26902610 |
| 47 | histone arginine methylation (GO:0034969) | 3.25168305 |
| 48 | righting reflex (GO:0060013) | 3.24557058 |
| 49 | presynaptic membrane organization (GO:0097090) | 3.21068594 |
| 50 | neuromuscular process controlling balance (GO:0050885) | 3.20600788 |
| 51 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.18289031 |
| 52 | startle response (GO:0001964) | 3.18174545 |
| 53 | neuron projection extension (GO:1990138) | 3.17038470 |
| 54 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.16285689 |
| 55 | response to dietary excess (GO:0002021) | 3.16204073 |
| 56 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.15750307 |
| 57 | organelle transport along microtubule (GO:0072384) | 3.15372844 |
| 58 | regulation of neurotransmitter secretion (GO:0046928) | 3.14165824 |
| 59 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.12095407 |
| 60 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.12095033 |
| 61 | gamma-aminobutyric acid transport (GO:0015812) | 3.11878447 |
| 62 | establishment of mitochondrion localization (GO:0051654) | 3.11820054 |
| 63 | synapse assembly (GO:0007416) | 3.11218712 |
| 64 | synaptic vesicle endocytosis (GO:0048488) | 3.10999347 |
| 65 | detection of temperature stimulus (GO:0016048) | 3.10956348 |
| 66 | regulation of vesicle fusion (GO:0031338) | 3.10707708 |
| 67 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.07554216 |
| 68 | positive regulation of membrane potential (GO:0045838) | 3.07231549 |
| 69 | regulation of postsynaptic membrane potential (GO:0060078) | 3.06466304 |
| 70 | clathrin coat assembly (GO:0048268) | 3.05688684 |
| 71 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.05544576 |
| 72 | mitochondrion transport along microtubule (GO:0047497) | 3.05544576 |
| 73 | regulation of synaptic plasticity (GO:0048167) | 3.05360419 |
| 74 | transmission of nerve impulse (GO:0019226) | 3.02276708 |
| 75 | neurotransmitter transport (GO:0006836) | 3.00736261 |
| 76 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.98955646 |
| 77 | vesicle transport along microtubule (GO:0047496) | 2.98777665 |
| 78 | negative regulation of dendrite development (GO:2000171) | 2.97754682 |
| 79 | axon cargo transport (GO:0008088) | 2.94419666 |
| 80 | presynaptic membrane assembly (GO:0097105) | 2.94185808 |
| 81 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.92978473 |
| 82 | hippocampus development (GO:0021766) | 2.90651079 |
| 83 | behavioral defense response (GO:0002209) | 2.89891106 |
| 84 | behavioral fear response (GO:0001662) | 2.89891106 |
| 85 | mesenchymal to epithelial transition (GO:0060231) | 2.89675444 |
| 86 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.89520752 |
| 87 | peptidyl-arginine N-methylation (GO:0035246) | 2.88047279 |
| 88 | peptidyl-arginine methylation (GO:0018216) | 2.88047279 |
| 89 | cell communication by electrical coupling (GO:0010644) | 2.88000251 |
| 90 | cerebellar granule cell differentiation (GO:0021707) | 2.87995475 |
| 91 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.87539867 |
| 92 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.87063528 |
| 93 | positive regulation of synapse assembly (GO:0051965) | 2.86102694 |
| 94 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.86040362 |
| 95 | cerebellum development (GO:0021549) | 2.85249257 |
| 96 | mating behavior (GO:0007617) | 2.85064647 |
| 97 | synapse organization (GO:0050808) | 2.85051578 |
| 98 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.84918475 |
| 99 | long-term memory (GO:0007616) | 2.84766231 |
| 100 | regulation of respiratory system process (GO:0044065) | 2.83596156 |
| 101 | auditory behavior (GO:0031223) | 2.83095806 |
| 102 | cerebral cortex neuron differentiation (GO:0021895) | 2.82335833 |
| 103 | retinal ganglion cell axon guidance (GO:0031290) | 2.81323977 |
| 104 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.81107657 |
| 105 | neuromuscular process (GO:0050905) | 2.80575503 |
| 106 | protein insertion into membrane (GO:0051205) | 2.79702611 |
| 107 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.78276248 |
| 108 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.78053113 |
| 109 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 2.76653872 |
| 110 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 2.76653872 |
| 111 | positive regulation of dendritic spine development (GO:0060999) | 2.75755359 |
| 112 | response to auditory stimulus (GO:0010996) | 2.75724324 |
| 113 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.75388975 |
| 114 | dopamine receptor signaling pathway (GO:0007212) | 2.75028664 |
| 115 | membrane depolarization (GO:0051899) | 2.74944519 |
| 116 | dendrite development (GO:0016358) | 2.74889586 |
| 117 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.69863080 |
| 118 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.66953479 |
| 119 | regulation of synapse assembly (GO:0051963) | 2.60588481 |
| 120 | cranial nerve morphogenesis (GO:0021602) | 2.60214004 |
| 121 | dendritic spine organization (GO:0097061) | 2.57450525 |
| 122 | adult walking behavior (GO:0007628) | 2.51904415 |
| 123 | regulation of synapse organization (GO:0050807) | 2.47370067 |
| 124 | cellular potassium ion homeostasis (GO:0030007) | 2.44994281 |
| 125 | cerebellar Purkinje cell layer development (GO:0021680) | 2.43195468 |
| 126 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.42392884 |
| 127 | neurofilament cytoskeleton organization (GO:0060052) | 2.41064212 |
| 128 | dorsal/ventral neural tube patterning (GO:0021904) | 2.36227209 |
| 129 | epithelial cell differentiation involved in kidney development (GO:0035850) | 2.31380869 |
| 130 | regulation of synapse maturation (GO:0090128) | 2.30511354 |
| 131 | skeletal muscle organ development (GO:0060538) | 2.29094615 |
| 132 | neuron projection regeneration (GO:0031102) | 2.27668367 |
| 133 | respiratory system process (GO:0003016) | 2.24965746 |
| 134 | regulation of neurotransmitter levels (GO:0001505) | 2.24694016 |
| 135 | nervous system development (GO:0007399) | 2.24139858 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.36444360 |
| 2 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.37961510 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.26653101 |
| 4 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.21110466 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.12579936 |
| 6 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.06733548 |
| 7 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 3.03791889 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 3.03206645 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 3.03206645 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 3.01273413 |
| 11 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.96752186 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.73985404 |
| 13 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.71497980 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.68203316 |
| 15 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.63912710 |
| 16 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.58030059 |
| 17 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.53242796 |
| 18 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.50390170 |
| 19 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.49718873 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.48315602 |
| 21 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.40290848 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.36364647 |
| 23 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.22034198 |
| 24 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.21571793 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.14202802 |
| 26 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.06269316 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.99027293 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.94753441 |
| 29 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.90276389 |
| 30 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.88974406 |
| 31 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.84505953 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.83019989 |
| 33 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.80107471 |
| 34 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.79208949 |
| 35 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.78726156 |
| 36 | * TAF15_26573619_Chip-Seq_HEK293_Human | 1.77780669 |
| 37 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.74685078 |
| 38 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.72042571 |
| 39 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.71331582 |
| 40 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.70663334 |
| 41 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.68167442 |
| 42 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.68167442 |
| 43 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.68167442 |
| 44 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.66500432 |
| 45 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.65889863 |
| 46 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.57863593 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.56492373 |
| 48 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.48313096 |
| 49 | * RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.47204688 |
| 50 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.45351348 |
| 51 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.44667007 |
| 52 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.44550460 |
| 53 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.42111316 |
| 54 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.41178246 |
| 55 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.40885991 |
| 56 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.40385177 |
| 57 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.36897926 |
| 58 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.36816820 |
| 59 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.35349487 |
| 60 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.34495399 |
| 61 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.33947592 |
| 62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.29509731 |
| 63 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.28612641 |
| 64 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.28487984 |
| 65 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28387640 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.25493913 |
| 67 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.23978400 |
| 68 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.23178708 |
| 69 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.22665038 |
| 70 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.22162750 |
| 71 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.19243746 |
| 72 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.19165011 |
| 73 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.18540411 |
| 74 | KDM2B_26808549_Chip-Seq_K562_Human | 1.18285047 |
| 75 | * SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.18044571 |
| 76 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.17813505 |
| 77 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.16321442 |
| 78 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.15873487 |
| 79 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.14790818 |
| 80 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.14525037 |
| 81 | AR_25329375_ChIP-Seq_VCAP_Human | 1.12783306 |
| 82 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12171882 |
| 83 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.12166166 |
| 84 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.09471539 |
| 85 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.09404701 |
| 86 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08234669 |
| 87 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.07905413 |
| 88 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.07199417 |
| 89 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05227984 |
| 90 | * AR_19668381_ChIP-Seq_PC3_Human | 1.04378383 |
| 91 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.04375251 |
| 92 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.04151749 |
| 93 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.02637688 |
| 94 | * SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.02427918 |
| 95 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.02085261 |
| 96 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.00809132 |
| 97 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00423031 |
| 98 | * AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00338751 |
| 99 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.00146786 |
| 100 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.99964825 |
| 101 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.99516416 |
| 102 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99111619 |
| 103 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.99011553 |
| 104 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.98428960 |
| 105 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.98161188 |
| 106 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97711121 |
| 107 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.97128981 |
| 108 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.96214364 |
| 109 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95745102 |
| 110 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.94625700 |
| 111 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.94497675 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94497675 |
| 113 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.93494899 |
| 114 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.92615786 |
| 115 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.92386570 |
| 116 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.91730648 |
| 117 | STAT3_23295773_ChIP-Seq_U87_Human | 0.90804394 |
| 118 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.90513306 |
| 119 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.89603750 |
| 120 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.89506063 |
| 121 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.89357818 |
| 122 | * POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.89112389 |
| 123 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.88369148 |
| 124 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.88109002 |
| 125 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.87617278 |
| 126 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.87237692 |
| 127 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.87093076 |
| 128 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.86955215 |
| 129 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.86876011 |
| 130 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.86517121 |
| 131 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.86426088 |
| 132 | * JUN_21703547_ChIP-Seq_K562_Human | 0.85897557 |
| 133 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.85798552 |
| 134 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.85237637 |
| 135 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.83750219 |
| 136 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.83349649 |
| 137 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.83319923 |
| 138 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.82438899 |
| 139 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.82311660 |
| 140 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.82299940 |
| 141 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.81544874 |
| 142 | * TTF2_22483619_ChIP-Seq_HELA_Human | 0.81343819 |
| 143 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.81090996 |
| 144 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.81060026 |
| 145 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.80063075 |
| 146 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.79276328 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.79121582 |
| 2 | MP0003880_abnormal_central_pattern | 4.52498960 |
| 3 | MP0004270_analgesia | 4.06789505 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.67997009 |
| 5 | MP0001968_abnormal_touch/_nociception | 3.48331560 |
| 6 | MP0002735_abnormal_chemical_nociception | 3.09211367 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.02900478 |
| 8 | MP0002734_abnormal_mechanical_nocicepti | 2.93331018 |
| 9 | MP0002736_abnormal_nociception_after | 2.89444814 |
| 10 | MP0009745_abnormal_behavioral_response | 2.76758832 |
| 11 | MP0004858_abnormal_nervous_system | 2.75056040 |
| 12 | MP0000778_abnormal_nervous_system | 2.70950601 |
| 13 | MP0002733_abnormal_thermal_nociception | 2.69384388 |
| 14 | MP0005423_abnormal_somatic_nervous | 2.68472523 |
| 15 | MP0006276_abnormal_autonomic_nervous | 2.65416793 |
| 16 | MP0002064_seizures | 2.63741519 |
| 17 | MP0002572_abnormal_emotion/affect_behav | 2.49872650 |
| 18 | MP0002184_abnormal_innervation | 2.38287487 |
| 19 | MP0001970_abnormal_pain_threshold | 2.36591130 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.24871464 |
| 21 | MP0009046_muscle_twitch | 2.20829487 |
| 22 | MP0001486_abnormal_startle_reflex | 2.12143782 |
| 23 | MP0002272_abnormal_nervous_system | 2.08054498 |
| 24 | MP0004811_abnormal_neuron_physiology | 1.99500939 |
| 25 | MP0002067_abnormal_sensory_capabilities | 1.90554055 |
| 26 | MP0004133_heterotaxia | 1.84445975 |
| 27 | MP0000955_abnormal_spinal_cord | 1.80827246 |
| 28 | MP0002557_abnormal_social/conspecific_i | 1.79133168 |
| 29 | MP0000049_abnormal_middle_ear | 1.77385907 |
| 30 | MP0003329_amyloid_beta_deposits | 1.76227914 |
| 31 | MP0001984_abnormal_olfaction | 1.73717081 |
| 32 | MP0003879_abnormal_hair_cell | 1.63510519 |
| 33 | MP0009780_abnormal_chondrocyte_physiolo | 1.62480537 |
| 34 | MP0005645_abnormal_hypothalamus_physiol | 1.62368969 |
| 35 | MP0002882_abnormal_neuron_morphology | 1.61571520 |
| 36 | MP0004924_abnormal_behavior | 1.61203171 |
| 37 | MP0005386_behavior/neurological_phenoty | 1.61203171 |
| 38 | MP0001501_abnormal_sleep_pattern | 1.59627157 |
| 39 | MP0003122_maternal_imprinting | 1.55654087 |
| 40 | MP0002249_abnormal_larynx_morphology | 1.48750130 |
| 41 | MP0005499_abnormal_olfactory_system | 1.45030241 |
| 42 | MP0005394_taste/olfaction_phenotype | 1.45030241 |
| 43 | MP0008569_lethality_at_weaning | 1.39912214 |
| 44 | MP0003136_yellow_coat_color | 1.39849210 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.34110266 |
| 46 | MP0002152_abnormal_brain_morphology | 1.31110834 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.29717069 |
| 48 | MP0003787_abnormal_imprinting | 1.29509239 |
| 49 | MP0003937_abnormal_limbs/digits/tail_de | 1.26842720 |
| 50 | MP0003123_paternal_imprinting | 1.22467748 |
| 51 | MP0000751_myopathy | 1.20514485 |
| 52 | MP0004885_abnormal_endolymph | 1.20243220 |
| 53 | MP0004742_abnormal_vestibular_system | 1.18983884 |
| 54 | MP0006292_abnormal_olfactory_placode | 1.16722871 |
| 55 | MP0003890_abnormal_embryonic-extraembry | 1.16666265 |
| 56 | MP0000579_abnormal_nail_morphology | 1.14721128 |
| 57 | MP0002234_abnormal_pharynx_morphology | 1.14570620 |
| 58 | MP0010030_abnormal_orbit_morphology | 1.13938984 |
| 59 | MP0008789_abnormal_olfactory_epithelium | 1.13608714 |
| 60 | MP0001502_abnormal_circadian_rhythm | 1.13603054 |
| 61 | MP0002751_abnormal_autonomic_nervous | 1.13211644 |
| 62 | MP0001346_abnormal_lacrimal_gland | 1.12266176 |
| 63 | MP0004142_abnormal_muscle_tone | 1.12062683 |
| 64 | MP0005646_abnormal_pituitary_gland | 1.09153473 |
| 65 | MP0002752_abnormal_somatic_nervous | 1.08407325 |
| 66 | MP0001529_abnormal_vocalization | 1.07920999 |
| 67 | MP0002697_abnormal_eye_size | 1.07823776 |
| 68 | MP0000631_abnormal_neuroendocrine_gland | 1.07255352 |
| 69 | MP0000569_abnormal_digit_pigmentation | 1.07153978 |
| 70 | MP0002822_catalepsy | 1.06510900 |
| 71 | MP0003567_abnormal_fetal_cardiomyocyte | 1.06099000 |
| 72 | MP0001348_abnormal_lacrimal_gland | 1.02195541 |
| 73 | MP0005623_abnormal_meninges_morphology | 1.00565438 |
| 74 | MP0001905_abnormal_dopamine_level | 0.99600826 |
| 75 | MP0003861_abnormal_nervous_system | 0.99508988 |
| 76 | MP0003385_abnormal_body_wall | 0.95191013 |
| 77 | MP0005187_abnormal_penis_morphology | 0.93678336 |
| 78 | MP0008877_abnormal_DNA_methylation | 0.93313907 |
| 79 | MP0001963_abnormal_hearing_physiology | 0.90557319 |
| 80 | MP0008932_abnormal_embryonic_tissue | 0.90095519 |
| 81 | MP0002069_abnormal_eating/drinking_beha | 0.90032254 |
| 82 | MP0003634_abnormal_glial_cell | 0.88856649 |
| 83 | MP0002653_abnormal_ependyma_morphology | 0.88404994 |
| 84 | MP0003693_abnormal_embryo_hatching | 0.88032667 |
| 85 | MP0001286_abnormal_eye_development | 0.86230138 |
| 86 | MP0001293_anophthalmia | 0.84877362 |
| 87 | MP0000537_abnormal_urethra_morphology | 0.84816730 |
| 88 | MP0002229_neurodegeneration | 0.82035258 |
| 89 | MP0001188_hyperpigmentation | 0.81873179 |
| 90 | MP0000534_abnormal_ureter_morphology | 0.81357494 |
| 91 | MP0003633_abnormal_nervous_system | 0.80999325 |
| 92 | MP0009250_abnormal_appendicular_skeleto | 0.80408621 |
| 93 | MP0003137_abnormal_impulse_conducting | 0.78944671 |
| 94 | MP0009672_abnormal_birth_weight | 0.76931568 |
| 95 | MP0008961_abnormal_basal_metabolism | 0.75948661 |
| 96 | MP0000026_abnormal_inner_ear | 0.75846611 |
| 97 | MP0002233_abnormal_nose_morphology | 0.75460171 |
| 98 | MP0003631_nervous_system_phenotype | 0.75131571 |
| 99 | MP0002837_dystrophic_cardiac_calcinosis | 0.75097513 |
| 100 | MP0001664_abnormal_digestion | 0.74446202 |
| 101 | MP0001485_abnormal_pinna_reflex | 0.74217865 |
| 102 | MP0005367_renal/urinary_system_phenotyp | 0.74180590 |
| 103 | MP0000516_abnormal_urinary_system | 0.74180590 |
| 104 | MP0010386_abnormal_urinary_bladder | 0.73982143 |
| 105 | MP0010768_mortality/aging | 0.73290816 |
| 106 | MP0003942_abnormal_urinary_system | 0.71843440 |
| 107 | MP0004085_abnormal_heartbeat | 0.70700732 |
| 108 | MP0000604_amyloidosis | 0.70423806 |
| 109 | MP0009379_abnormal_foot_pigmentation | 0.67083104 |
| 110 | MP0001299_abnormal_eye_distance/ | 0.65796434 |
| 111 | MP0003283_abnormal_digestive_organ | 0.65454746 |
| 112 | MP0001943_abnormal_respiration | 0.64431836 |
| 113 | MP0002102_abnormal_ear_morphology | 0.63066291 |
| 114 | MP0002638_abnormal_pupillary_reflex | 0.62541143 |
| 115 | MP0003938_abnormal_ear_development | 0.61990327 |
| 116 | MP0003121_genomic_imprinting | 0.60963522 |
| 117 | MP0006072_abnormal_retinal_apoptosis | 0.60422027 |
| 118 | MP0001177_atelectasis | 0.58838657 |
| 119 | MP0008874_decreased_physiological_sensi | 0.58394780 |
| 120 | MP0005551_abnormal_eye_electrophysiolog | 0.57732586 |
| 121 | MP0002081_perinatal_lethality | 0.56070841 |
| 122 | MP0008872_abnormal_physiological_respon | 0.54969705 |
| 123 | MP0010769_abnormal_survival | 0.54759709 |
| 124 | MP0002082_postnatal_lethality | 0.54699185 |
| 125 | MP0010770_preweaning_lethality | 0.54699185 |
| 126 | MP0004145_abnormal_muscle_electrophysio | 0.53753683 |
| 127 | MP0003119_abnormal_digestive_system | 0.52460020 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.41040818 |
| 2 | Focal motor seizures (HP:0011153) | 5.58958448 |
| 3 | Focal seizures (HP:0007359) | 4.70626379 |
| 4 | Visual hallucinations (HP:0002367) | 4.46194917 |
| 5 | Epileptic encephalopathy (HP:0200134) | 3.90909978 |
| 6 | Supranuclear gaze palsy (HP:0000605) | 3.83600185 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 3.71529656 |
| 8 | Atonic seizures (HP:0010819) | 3.68748177 |
| 9 | Ankle clonus (HP:0011448) | 3.45594188 |
| 10 | Febrile seizures (HP:0002373) | 3.38846504 |
| 11 | Action tremor (HP:0002345) | 3.34542768 |
| 12 | Absence seizures (HP:0002121) | 3.32925439 |
| 13 | Mutism (HP:0002300) | 3.29326390 |
| 14 | Amblyopia (HP:0000646) | 3.25893334 |
| 15 | Generalized tonic-clonic seizures (HP:0002069) | 3.07088465 |
| 16 | Limb dystonia (HP:0002451) | 3.05530581 |
| 17 | Termporal pattern (HP:0011008) | 3.03206532 |
| 18 | Insidious onset (HP:0003587) | 3.03206532 |
| 19 | Dialeptic seizures (HP:0011146) | 3.01025083 |
| 20 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.99504145 |
| 21 | Papilledema (HP:0001085) | 2.93521225 |
| 22 | Polyphagia (HP:0002591) | 2.87703070 |
| 23 | Depression (HP:0000716) | 2.84868943 |
| 24 | Broad-based gait (HP:0002136) | 2.84341930 |
| 25 | Hypoplasia of the brainstem (HP:0002365) | 2.82031805 |
| 26 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.82031805 |
| 27 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.80493250 |
| 28 | Congenital malformation of the right heart (HP:0011723) | 2.77145181 |
| 29 | Double outlet right ventricle (HP:0001719) | 2.77145181 |
| 30 | Abnormality of the lower motor neuron (HP:0002366) | 2.69466145 |
| 31 | Pheochromocytoma (HP:0002666) | 2.69067367 |
| 32 | Urinary urgency (HP:0000012) | 2.68167934 |
| 33 | Abnormal eating behavior (HP:0100738) | 2.66971380 |
| 34 | Abnormality of the corticospinal tract (HP:0002492) | 2.66561318 |
| 35 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.66035512 |
| 36 | Failure to thrive in infancy (HP:0001531) | 2.63019442 |
| 37 | Cortical dysplasia (HP:0002539) | 2.59650833 |
| 38 | Amyotrophic lateral sclerosis (HP:0007354) | 2.58075603 |
| 39 | Anxiety (HP:0000739) | 2.57942810 |
| 40 | Hyperventilation (HP:0002883) | 2.57113300 |
| 41 | Excessive salivation (HP:0003781) | 2.56769293 |
| 42 | Drooling (HP:0002307) | 2.56769293 |
| 43 | Truncal ataxia (HP:0002078) | 2.56572569 |
| 44 | Akinesia (HP:0002304) | 2.55581869 |
| 45 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.52106102 |
| 46 | Transposition of the great arteries (HP:0001669) | 2.52106102 |
| 47 | Abnormal connection of the cardiac segments (HP:0011545) | 2.52106102 |
| 48 | Cerebral inclusion bodies (HP:0100314) | 2.51304636 |
| 49 | Agitation (HP:0000713) | 2.51150889 |
| 50 | Colon cancer (HP:0003003) | 2.47852521 |
| 51 | Abnormality of the aortic arch (HP:0012303) | 2.44386530 |
| 52 | Megalencephaly (HP:0001355) | 2.44290488 |
| 53 | Poor eye contact (HP:0000817) | 2.40977806 |
| 54 | Progressive inability to walk (HP:0002505) | 2.34972479 |
| 55 | Neuroendocrine neoplasm (HP:0100634) | 2.32215200 |
| 56 | Insomnia (HP:0100785) | 2.31945524 |
| 57 | Spastic gait (HP:0002064) | 2.30243410 |
| 58 | Neurofibrillary tangles (HP:0002185) | 2.29019949 |
| 59 | Ulnar claw (HP:0001178) | 2.26635965 |
| 60 | Fetal akinesia sequence (HP:0001989) | 2.26135069 |
| 61 | Septo-optic dysplasia (HP:0100842) | 2.25969797 |
| 62 | Torticollis (HP:0000473) | 2.24365502 |
| 63 | Focal dystonia (HP:0004373) | 2.22920675 |
| 64 | Epileptiform EEG discharges (HP:0011182) | 2.21800064 |
| 65 | Abnormality of binocular vision (HP:0011514) | 2.21548076 |
| 66 | Diplopia (HP:0000651) | 2.21548076 |
| 67 | Periauricular skin pits (HP:0100277) | 2.18835827 |
| 68 | Preauricular pit (HP:0004467) | 2.18835827 |
| 69 | Hypoventilation (HP:0002791) | 2.18286316 |
| 70 | Myotonia (HP:0002486) | 2.18165418 |
| 71 | Hypoplastic left heart (HP:0004383) | 2.17941996 |
| 72 | Hemiparesis (HP:0001269) | 2.17851163 |
| 73 | EEG with generalized epileptiform discharges (HP:0011198) | 2.17478493 |
| 74 | Sleep apnea (HP:0010535) | 2.16635551 |
| 75 | Apathy (HP:0000741) | 2.15016852 |
| 76 | High anterior hairline (HP:0009890) | 2.13317612 |
| 77 | Genetic anticipation (HP:0003743) | 2.11730495 |
| 78 | Specific learning disability (HP:0001328) | 2.11366017 |
| 79 | Gaze-evoked nystagmus (HP:0000640) | 2.09249076 |
| 80 | Obstructive sleep apnea (HP:0002870) | 2.08425073 |
| 81 | Hypsarrhythmia (HP:0002521) | 2.08249142 |
| 82 | Impaired social interactions (HP:0000735) | 2.06504285 |
| 83 | Abnormal social behavior (HP:0012433) | 2.06504285 |
| 84 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.06358399 |
| 85 | Inability to walk (HP:0002540) | 2.06117560 |
| 86 | Gait imbalance (HP:0002141) | 2.05949125 |
| 87 | Broad distal phalanx of finger (HP:0009836) | 2.05734243 |
| 88 | Split foot (HP:0001839) | 2.05583162 |
| 89 | Delusions (HP:0000746) | 2.04426206 |
| 90 | Hyperthyroidism (HP:0000836) | 2.03837473 |
| 91 | Craniofacial dystonia (HP:0012179) | 2.03735245 |
| 92 | Lissencephaly (HP:0001339) | 2.03387080 |
| 93 | Lower limb muscle weakness (HP:0007340) | 2.02934031 |
| 94 | Exotropia (HP:0000577) | 1.98895588 |
| 95 | Generalized hypotonia (HP:0001290) | 1.97528169 |
| 96 | Cutaneous syndactyly (HP:0012725) | 1.97474214 |
| 97 | Cerebral hypomyelination (HP:0006808) | 1.96109495 |
| 98 | Cutaneous finger syndactyly (HP:0010554) | 1.95385643 |
| 99 | Restlessness (HP:0000711) | 1.95020325 |
| 100 | Shoulder girdle muscle weakness (HP:0003547) | 1.94195064 |
| 101 | Dysmetria (HP:0001310) | 1.93594356 |
| 102 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.93343030 |
| 103 | Diminished motivation (HP:0000745) | 1.92804209 |
| 104 | Bradykinesia (HP:0002067) | 1.92544580 |
| 105 | Impaired pain sensation (HP:0007328) | 1.91340305 |
| 106 | Abnormality of pain sensation (HP:0010832) | 1.91340305 |
| 107 | Peripheral hypomyelination (HP:0007182) | 1.89736972 |
| 108 | Stereotypic behavior (HP:0000733) | 1.89223369 |
| 109 | Absent speech (HP:0001344) | 1.89199198 |
| 110 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.89026325 |
| 111 | Truncus arteriosus (HP:0001660) | 1.87486316 |
| 112 | Hepatoblastoma (HP:0002884) | 1.87394102 |
| 113 | Oligodactyly (HP:0012165) | 1.84286116 |
| 114 | Diminished movement (HP:0002374) | 1.84148029 |
| 115 | Oligodactyly (hands) (HP:0001180) | 1.82997041 |
| 116 | Pachygyria (HP:0001302) | 1.82576443 |
| 117 | Hypercortisolism (HP:0001578) | 1.82435475 |
| 118 | Inappropriate behavior (HP:0000719) | 1.82040498 |
| 119 | Poor suck (HP:0002033) | 1.81789581 |
| 120 | Dysdiadochokinesis (HP:0002075) | 1.80691011 |
| 121 | Retinal dysplasia (HP:0007973) | 1.79964331 |
| 122 | Unilateral renal agenesis (HP:0000122) | 1.79952709 |
| 123 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.79708752 |
| 124 | Pointed chin (HP:0000307) | 1.79107534 |
| 125 | Anophthalmia (HP:0000528) | 1.79063416 |
| 126 | Sporadic (HP:0003745) | 1.78428227 |
| 127 | Turricephaly (HP:0000262) | 1.77412100 |
| 128 | Abnormality of the labia minora (HP:0012880) | 1.77110680 |
| 129 | Rapidly progressive (HP:0003678) | 1.76656927 |
| 130 | Abnormality of abdominal situs (HP:0011620) | 1.76127357 |
| 131 | Abdominal situs inversus (HP:0003363) | 1.76127357 |
| 132 | Cerebellar dysplasia (HP:0007033) | 1.75752522 |
| 133 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.75433210 |
| 134 | Hypoplastic heart (HP:0001961) | 1.74597250 |
| 135 | Maternal diabetes (HP:0009800) | 1.71737075 |
| 136 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.70337876 |
| 137 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.70337876 |
| 138 | Myelomeningocele (HP:0002475) | 1.64351064 |
| 139 | Absent septum pellucidum (HP:0001331) | 1.63063180 |
| 140 | Astrocytoma (HP:0009592) | 1.62930266 |
| 141 | Abnormality of the astrocytes (HP:0100707) | 1.62930266 |
| 142 | Rib fusion (HP:0000902) | 1.61501173 |
| 143 | Renal dysplasia (HP:0000110) | 1.60709497 |
| 144 | Abnormality of cochlea (HP:0000375) | 1.59146708 |
| 145 | Down-sloping shoulders (HP:0200021) | 1.58547498 |
| 146 | Optic nerve coloboma (HP:0000588) | 1.58278699 |
| 147 | Sclerocornea (HP:0000647) | 1.57825490 |
| 148 | Mixed hearing impairment (HP:0000410) | 1.57406139 |
| 149 | Polymicrogyria (HP:0002126) | 1.55353032 |
| 150 | Esotropia (HP:0000565) | 1.53426587 |
| 151 | Type II lissencephaly (HP:0007260) | 1.52048325 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.30495522 |
| 2 | NTRK3 | 3.73113278 |
| 3 | MAP3K9 | 3.72163943 |
| 4 | MAP3K4 | 3.14099486 |
| 5 | MINK1 | 2.99648025 |
| 6 | MAP2K7 | 2.69191624 |
| 7 | EPHA4 | 2.40459309 |
| 8 | MAPK13 | 2.40438161 |
| 9 | DAPK2 | 2.40252202 |
| 10 | TAF1 | 2.28817673 |
| 11 | NTRK2 | 2.12746410 |
| 12 | PAK6 | 2.12148551 |
| 13 | MAP3K12 | 2.07752663 |
| 14 | CASK | 2.07615189 |
| 15 | KSR2 | 1.99590271 |
| 16 | LATS2 | 1.97463320 |
| 17 | VRK2 | 1.94727815 |
| 18 | MAP2K4 | 1.92574242 |
| 19 | SMG1 | 1.90958737 |
| 20 | PHKG1 | 1.85607861 |
| 21 | PHKG2 | 1.85607861 |
| 22 | GRK5 | 1.85034601 |
| 23 | KSR1 | 1.69603503 |
| 24 | NTRK1 | 1.69159112 |
| 25 | ARAF | 1.63549306 |
| 26 | PLK2 | 1.62141270 |
| 27 | LIMK1 | 1.57331467 |
| 28 | DYRK2 | 1.50556145 |
| 29 | SIK2 | 1.49173674 |
| 30 | UHMK1 | 1.47871622 |
| 31 | CDK5 | 1.47375631 |
| 32 | DAPK1 | 1.44275076 |
| 33 | CAMKK1 | 1.39062227 |
| 34 | PNCK | 1.23694816 |
| 35 | MAP3K2 | 1.17604486 |
| 36 | BRSK1 | 1.16779393 |
| 37 | CDK19 | 1.13655313 |
| 38 | RET | 1.12919727 |
| 39 | CDK14 | 1.11876035 |
| 40 | ERBB3 | 1.11280774 |
| 41 | CSNK1G2 | 1.06077228 |
| 42 | PRKCG | 1.05917288 |
| 43 | CDK18 | 1.05724527 |
| 44 | ICK | 1.05629422 |
| 45 | CDK15 | 1.01307701 |
| 46 | TLK1 | 1.00722514 |
| 47 | RIPK4 | 0.97861041 |
| 48 | CHEK2 | 0.95249073 |
| 49 | PTK2B | 0.93766215 |
| 50 | LMTK2 | 0.90846631 |
| 51 | TNIK | 0.89610798 |
| 52 | CDK11A | 0.89364892 |
| 53 | PAK3 | 0.88243594 |
| 54 | AURKA | 0.87520214 |
| 55 | EPHB2 | 0.86169653 |
| 56 | CAMKK2 | 0.85165961 |
| 57 | TYRO3 | 0.85042307 |
| 58 | TAOK1 | 0.82296742 |
| 59 | NME1 | 0.81627683 |
| 60 | ZAK | 0.80254568 |
| 61 | CAMK2A | 0.79820767 |
| 62 | PRKD3 | 0.79795433 |
| 63 | TRIM28 | 0.78942555 |
| 64 | RPS6KA2 | 0.78778852 |
| 65 | MARK2 | 0.78203780 |
| 66 | CAMK1D | 0.77947369 |
| 67 | DYRK1A | 0.76780529 |
| 68 | CDC7 | 0.74645406 |
| 69 | MAP3K10 | 0.74447171 |
| 70 | MAP3K11 | 0.72724630 |
| 71 | EEF2K | 0.72309403 |
| 72 | CSNK1G3 | 0.70507432 |
| 73 | TESK1 | 0.66478252 |
| 74 | MAP3K6 | 0.65471257 |
| 75 | BCR | 0.65442192 |
| 76 | PRKCZ | 0.60619882 |
| 77 | FER | 0.59426483 |
| 78 | RAF1 | 0.59206154 |
| 79 | CSNK1E | 0.58223428 |
| 80 | MAP2K1 | 0.58106173 |
| 81 | PBK | 0.57967594 |
| 82 | SGK223 | 0.57642310 |
| 83 | SGK494 | 0.57642310 |
| 84 | FES | 0.56263120 |
| 85 | SRPK1 | 0.55845250 |
| 86 | PRPF4B | 0.54941681 |
| 87 | CAMK2B | 0.54582632 |
| 88 | PDK2 | 0.53847872 |
| 89 | CCNB1 | 0.53302224 |
| 90 | STK11 | 0.53181354 |
| 91 | STK16 | 0.51685710 |
| 92 | VRK1 | 0.50833383 |
| 93 | DDR2 | 0.50348718 |
| 94 | CSNK1A1L | 0.50126679 |
| 95 | AKT2 | 0.50110225 |
| 96 | STK38 | 0.48465388 |
| 97 | SIK3 | 0.48404880 |
| 98 | DYRK3 | 0.46291333 |
| 99 | CAMK1 | 0.45813384 |
| 100 | DAPK3 | 0.45511296 |
| 101 | FGR | 0.45435000 |
| 102 | CSNK1D | 0.44363868 |
| 103 | ATR | 0.43077075 |
| 104 | ADRBK1 | 0.42790257 |
| 105 | ALK | 0.41429925 |
| 106 | PRKDC | 0.40090361 |
| 107 | MAP2K2 | 0.39864013 |
| 108 | EIF2AK2 | 0.39765127 |
| 109 | MAPK12 | 0.39594997 |
| 110 | PRKCE | 0.38355418 |
| 111 | CSNK1G1 | 0.36524564 |
| 112 | PRKCH | 0.36203107 |
| 113 | PRKAA1 | 0.35765970 |
| 114 | SCYL2 | 0.35740938 |
| 115 | CDK1 | 0.35155910 |
| 116 | BMPR2 | 0.35059581 |
| 117 | BRAF | 0.34964682 |
| 118 | CDK2 | 0.34708904 |
| 119 | PLK1 | 0.34557289 |
| 120 | FYN | 0.34403562 |
| 121 | OXSR1 | 0.34181343 |
| 122 | GSK3B | 0.33850081 |
| 123 | MAP3K1 | 0.33639114 |
| 124 | RPS6KA1 | 0.33530011 |
| 125 | CAMK1G | 0.33456309 |
| 126 | PKN1 | 0.33439201 |
| 127 | CAMK4 | 0.33179471 |
| 128 | NEK6 | 0.33071347 |
| 129 | ROCK2 | 0.32997056 |
| 130 | DYRK1B | 0.32860735 |
| 131 | MAPK10 | 0.32500710 |
| 132 | TESK2 | 0.31738687 |
| 133 | PRKCI | 0.30315051 |
| 134 | SGK2 | 0.29756576 |
| 135 | RPS6KA3 | 0.28297824 |
| 136 | MAPK9 | 0.28069329 |
| 137 | WNK3 | 0.27893680 |
| 138 | SGK1 | 0.27808266 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.44728426 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.15511955 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.69853580 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.35280423 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.34282940 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.32774060 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.27382130 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.24943525 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.23654331 |
| 10 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.14203181 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.13775769 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 2.12581949 |
| 13 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.02983415 |
| 14 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.92266243 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.86888584 |
| 16 | Taste transduction_Homo sapiens_hsa04742 | 1.81775070 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.76476123 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.75877074 |
| 19 | Salivary secretion_Homo sapiens_hsa04970 | 1.74978514 |
| 20 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.73737330 |
| 21 | Sulfur relay system_Homo sapiens_hsa04122 | 1.70495622 |
| 22 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.70027184 |
| 23 | Axon guidance_Homo sapiens_hsa04360 | 1.69400788 |
| 24 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.64409509 |
| 25 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.60984056 |
| 26 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.58692425 |
| 27 | Gap junction_Homo sapiens_hsa04540 | 1.56980981 |
| 28 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.53024999 |
| 29 | DNA replication_Homo sapiens_hsa03030 | 1.51467968 |
| 30 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.49184366 |
| 31 | Long-term depression_Homo sapiens_hsa04730 | 1.48818350 |
| 32 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.48642136 |
| 33 | Renin secretion_Homo sapiens_hsa04924 | 1.45558762 |
| 34 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.43863780 |
| 35 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.40790573 |
| 36 | Cocaine addiction_Homo sapiens_hsa05030 | 1.37445607 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.36547340 |
| 38 | Glioma_Homo sapiens_hsa05214 | 1.36433434 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.28611783 |
| 40 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.26851952 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.24194145 |
| 42 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.22910074 |
| 43 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.21337064 |
| 44 | Melanogenesis_Homo sapiens_hsa04916 | 1.21308790 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.21286046 |
| 46 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.18241972 |
| 47 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.08415894 |
| 48 | Mismatch repair_Homo sapiens_hsa03430 | 1.08275505 |
| 49 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.07875478 |
| 50 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.03964541 |
| 51 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.02923894 |
| 52 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.01835115 |
| 53 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.01587105 |
| 54 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.99648823 |
| 55 | Parkinsons disease_Homo sapiens_hsa05012 | 0.97084656 |
| 56 | Alzheimers disease_Homo sapiens_hsa05010 | 0.95413203 |
| 57 | Ribosome_Homo sapiens_hsa03010 | 0.94846354 |
| 58 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.92382701 |
| 59 | Endometrial cancer_Homo sapiens_hsa05213 | 0.91452231 |
| 60 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.91274616 |
| 61 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.91179942 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.90975305 |
| 63 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87906561 |
| 64 | Colorectal cancer_Homo sapiens_hsa05210 | 0.87886369 |
| 65 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.83922021 |
| 66 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.83265498 |
| 67 | Phototransduction_Homo sapiens_hsa04744 | 0.82439450 |
| 68 | Cell cycle_Homo sapiens_hsa04110 | 0.78259864 |
| 69 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.78258126 |
| 70 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.78167318 |
| 71 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.77677614 |
| 72 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.77353715 |
| 73 | Spliceosome_Homo sapiens_hsa03040 | 0.77250459 |
| 74 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.76757748 |
| 75 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.76495230 |
| 76 | Base excision repair_Homo sapiens_hsa03410 | 0.75866988 |
| 77 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.74261817 |
| 78 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.73398200 |
| 79 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.72850255 |
| 80 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.71239907 |
| 81 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71178205 |
| 82 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.70491744 |
| 83 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.70474711 |
| 84 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.70073173 |
| 85 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.69732289 |
| 86 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.68287761 |
| 87 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.68042631 |
| 88 | Prion diseases_Homo sapiens_hsa05020 | 0.67912275 |
| 89 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.67660700 |
| 90 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.67513307 |
| 91 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.66999230 |
| 92 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.66850460 |
| 93 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.66382317 |
| 94 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.65897530 |
| 95 | RNA polymerase_Homo sapiens_hsa03020 | 0.65570342 |
| 96 | Huntingtons disease_Homo sapiens_hsa05016 | 0.65539911 |
| 97 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.64189494 |
| 98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.62878616 |
| 99 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.61591688 |
| 100 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.61336009 |
| 101 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.59733143 |
| 102 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.59614290 |
| 103 | Alcoholism_Homo sapiens_hsa05034 | 0.59302001 |
| 104 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.58871305 |
| 105 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.58822406 |
| 106 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.57839167 |
| 107 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.56146077 |
| 108 | RNA transport_Homo sapiens_hsa03013 | 0.55886593 |
| 109 | Endocytosis_Homo sapiens_hsa04144 | 0.55584723 |
| 110 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55110196 |
| 111 | Melanoma_Homo sapiens_hsa05218 | 0.54260234 |
| 112 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.53529207 |
| 113 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.53133222 |
| 114 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.52734267 |
| 115 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.52311430 |
| 116 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51672028 |
| 117 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.50410943 |
| 118 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.48529537 |
| 119 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.48358674 |
| 120 | Tight junction_Homo sapiens_hsa04530 | 0.48294458 |
| 121 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.47359875 |
| 122 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.45751389 |
| 123 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.44666807 |
| 124 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.43558228 |
| 125 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.42472877 |
| 126 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.41933291 |
| 127 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.40065111 |
| 128 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39794331 |
| 129 | Phagosome_Homo sapiens_hsa04145 | 0.39226240 |
| 130 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36782632 |
| 131 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.31851254 |
| 132 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30804594 |

