RPS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.31044051
2* translational termination (GO:0006415)7.99048719
3ribosomal small subunit assembly (GO:0000028)7.85926472
4ribosomal small subunit biogenesis (GO:0042274)7.09625418
5* translational elongation (GO:0006414)6.97290296
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.68511297
7* protein targeting to ER (GO:0045047)6.53160814
8* cotranslational protein targeting to membrane (GO:0006613)6.50897054
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.42125174
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.23824152
11maturation of SSU-rRNA (GO:0030490)6.20670443
12* viral life cycle (GO:0019058)6.19415896
13* cellular protein complex disassembly (GO:0043624)6.16905022
14* translational initiation (GO:0006413)6.13878393
15* protein localization to endoplasmic reticulum (GO:0070972)6.07122549
16* protein complex disassembly (GO:0043241)5.53440770
17ribosomal large subunit biogenesis (GO:0042273)5.30836612
18* macromolecular complex disassembly (GO:0032984)5.14349995
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.90899145
20* nuclear-transcribed mRNA catabolic process (GO:0000956)4.64804168
21formation of translation preinitiation complex (GO:0001731)4.57479867
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42506547
23ATP synthesis coupled proton transport (GO:0015986)4.42506547
24* mRNA catabolic process (GO:0006402)4.41204391
25* protein targeting to membrane (GO:0006612)4.33823413
26ribonucleoprotein complex biogenesis (GO:0022613)4.29448200
27* RNA catabolic process (GO:0006401)4.19802899
28* translation (GO:0006412)4.16232087
29chaperone-mediated protein transport (GO:0072321)3.96543961
30DNA unwinding involved in DNA replication (GO:0006268)3.81478746
31DNA deamination (GO:0045006)3.79848827
32regulation of mitochondrial translation (GO:0070129)3.76278818
33DNA strand elongation involved in DNA replication (GO:0006271)3.75216547
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.70377887
35DNA strand elongation (GO:0022616)3.54808265
36telomere maintenance via semi-conservative replication (GO:0032201)3.46367925
37rRNA processing (GO:0006364)3.40028467
38folic acid-containing compound biosynthetic process (GO:0009396)3.37976068
39negative regulation of RNA splicing (GO:0033119)3.36368301
40mitotic chromosome condensation (GO:0007076)3.35274192
41protein localization to kinetochore (GO:0034501)3.32906752
42rRNA metabolic process (GO:0016072)3.28221658
43DNA replication initiation (GO:0006270)3.26889161
44respiratory electron transport chain (GO:0022904)3.25494931
45electron transport chain (GO:0022900)3.16019076
46nucleobase-containing small molecule interconversion (GO:0015949)3.15718649
47ncRNA 3-end processing (GO:0043628)3.15422063
48protein targeting to mitochondrion (GO:0006626)3.11970248
49* protein localization to membrane (GO:0072657)3.10294623
50UTP biosynthetic process (GO:0006228)3.08856706
51pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04736166
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03237711
53mitotic nuclear envelope disassembly (GO:0007077)3.00669905
54oxidative phosphorylation (GO:0006119)2.99825706
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99502723
56telomere maintenance via recombination (GO:0000722)2.97420199
57guanosine-containing compound biosynthetic process (GO:1901070)2.96549847
58mitotic recombination (GO:0006312)2.94714311
59cellular component biogenesis (GO:0044085)2.94221502
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93296752
61pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.93012458
62ribosome biogenesis (GO:0042254)2.92432324
63establishment of protein localization to mitochondrion (GO:0072655)2.92064576
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91363547
65* establishment of protein localization to membrane (GO:0090150)2.89253770
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87709810
67L-serine metabolic process (GO:0006563)2.87378533
68protein localization to chromosome, centromeric region (GO:0071459)2.86638016
69DNA replication-dependent nucleosome assembly (GO:0006335)2.84866672
70DNA replication-dependent nucleosome organization (GO:0034723)2.84866672
71GTP biosynthetic process (GO:0006183)2.84031730
72regulation of protein heterodimerization activity (GO:0043497)2.83737206
73nucleobase biosynthetic process (GO:0046112)2.81499120
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80853782
75spliceosomal snRNP assembly (GO:0000387)2.79783430
76IMP biosynthetic process (GO:0006188)2.79352101
77ribosome assembly (GO:0042255)2.77080888
78telomere maintenance via telomere lengthening (GO:0010833)2.76079389
79nuclear envelope disassembly (GO:0051081)2.75019674
80membrane disassembly (GO:0030397)2.75019674
81CTP biosynthetic process (GO:0006241)2.74857949
82CTP metabolic process (GO:0046036)2.74857949
83UTP metabolic process (GO:0046051)2.74781689
84protein localization to mitochondrion (GO:0070585)2.73137553
85rRNA modification (GO:0000154)2.71133836
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.71052506
87termination of RNA polymerase III transcription (GO:0006386)2.71052506
88* establishment of protein localization to organelle (GO:0072594)2.69912559
89pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.69007790
90DNA replication checkpoint (GO:0000076)2.68796601
91establishment of integrated proviral latency (GO:0075713)2.67127803
92* protein localization to organelle (GO:0033365)2.65899782
93negative regulation of ligase activity (GO:0051352)2.65150871
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65150871
95regulation of translational fidelity (GO:0006450)2.65134743
96mitotic sister chromatid segregation (GO:0000070)2.64071998
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63867684
98inner mitochondrial membrane organization (GO:0007007)2.63709589
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.63331934
100T cell apoptotic process (GO:0070231)2.62943111
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61003313
102mRNA splicing, via spliceosome (GO:0000398)2.61003313
103ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60802697
104RNA splicing, via transesterification reactions (GO:0000375)2.60100884
105spliceosomal complex assembly (GO:0000245)2.60025275
106* protein targeting (GO:0006605)2.58678792
107establishment of viral latency (GO:0019043)2.57186191
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56983678
109heterochromatin organization (GO:0070828)2.56651606
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54136708
111IMP metabolic process (GO:0046040)2.51409550
112* gene expression (GO:0010467)2.50739422
113termination of RNA polymerase II transcription (GO:0006369)2.49431832
114DNA duplex unwinding (GO:0032508)2.49196825
115* cellular component disassembly (GO:0022411)2.47589332
116mitotic metaphase plate congression (GO:0007080)2.46990997
117DNA geometric change (GO:0032392)2.46872112
118pseudouridine synthesis (GO:0001522)2.46363263
119negative regulation of mRNA processing (GO:0050686)2.46283555
120ribonucleoprotein complex assembly (GO:0022618)2.42121906
121purine nucleobase biosynthetic process (GO:0009113)2.39507725
122DNA replication-independent nucleosome organization (GO:0034724)2.36799282
123DNA replication-independent nucleosome assembly (GO:0006336)2.36799282
1243-UTR-mediated mRNA stabilization (GO:0070935)2.35991039
125regulation of gene silencing by RNA (GO:0060966)2.35845122
126regulation of posttranscriptional gene silencing (GO:0060147)2.35845122
127regulation of gene silencing by miRNA (GO:0060964)2.35845122
128regulation of histone H3-K9 methylation (GO:0051570)2.35301075
129nuclear pore organization (GO:0006999)2.34861295
130chromatin remodeling at centromere (GO:0031055)2.34502669
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34136088
132antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34136088
133ncRNA processing (GO:0034470)2.32348103
134CENP-A containing nucleosome assembly (GO:0034080)2.31612866
135transcription-coupled nucleotide-excision repair (GO:0006283)2.31577527
136kinetochore organization (GO:0051383)2.28969976
137chromatin assembly or disassembly (GO:0006333)2.28893948
138lymphocyte apoptotic process (GO:0070227)2.28840516
139ribonucleoprotein complex subunit organization (GO:0071826)2.27802587
140negative regulation of translational initiation (GO:0045947)2.27664397
141negative regulation of mRNA metabolic process (GO:1903312)2.26126449
142translesion synthesis (GO:0019985)2.23579123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44125627
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20710527
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94808416
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.21742599
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12419628
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69243485
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54866432
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53118801
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51051220
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50498940
11MYC_22102868_ChIP-Seq_BL_Human2.49429097
12* XRN2_22483619_ChIP-Seq_HELA_Human2.44529402
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.42569658
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.40581893
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.30763805
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.28545825
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11033743
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04215824
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03384389
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98662808
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94759447
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92948645
23VDR_21846776_ChIP-Seq_THP-1_Human1.92499403
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92122888
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90002313
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.89513768
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89288746
28VDR_23849224_ChIP-Seq_CD4+_Human1.89069319
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88036535
30TTF2_22483619_ChIP-Seq_HELA_Human1.82876220
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73817496
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72429289
33FOXP3_21729870_ChIP-Seq_TREG_Human1.68796621
34CIITA_25753668_ChIP-Seq_RAJI_Human1.59987646
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59157489
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57864522
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57027318
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.53834439
39GABP_19822575_ChIP-Seq_HepG2_Human1.53611990
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47745132
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45868919
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45703524
43AR_21909140_ChIP-Seq_LNCAP_Human1.41865329
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40458392
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40304476
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40255173
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36190770
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35966303
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35702176
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35330482
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34806547
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.33965230
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32430731
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31253263
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30849354
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30541275
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27455360
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26258956
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25744062
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24817703
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24670815
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24526301
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24169067
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23952575
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22798846
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21521763
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20199477
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19596109
69* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18807013
70MAF_26560356_Chip-Seq_TH1_Human1.18060758
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17200015
72UTX_26944678_Chip-Seq_JUKART_Human1.16936836
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16845787
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15329157
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.14477986
76SPI1_23547873_ChIP-Seq_NB4_Human1.12926351
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.11958942
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.11693235
79TFEB_21752829_ChIP-Seq_HELA_Human1.11040241
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10383944
81* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08013406
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06024271
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05938197
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05722208
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04718734
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04453400
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.03816318
88MAF_26560356_Chip-Seq_TH2_Human1.03689748
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03607966
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.02424128
91TCF7_22412390_ChIP-Seq_EML_Mouse1.01733472
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01709569
93MYC_18940864_ChIP-ChIP_HL60_Human1.01500898
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01020044
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00520991
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00172187
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.99289909
98VDR_24763502_ChIP-Seq_THP-1_Human0.97078721
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96950561
100ZNF263_19887448_ChIP-Seq_K562_Human0.96730261
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96719770
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96584748
103SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95688225
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.95118647
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95022320
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94962453
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94951118
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94525928
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93566515
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92903375
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92518760
112MYB_26560356_Chip-Seq_TH2_Human0.92089507
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91999850
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91102781
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90686030
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90391690
117ATF3_27146783_Chip-Seq_COLON_Human0.90108213
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89898318
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88875131
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88151112
121LXR_22292898_ChIP-Seq_THP-1_Human0.86452754
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.85171766
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83056775
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82641566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.93588100
2MP0004957_abnormal_blastocyst_morpholog3.44096593
3MP0003111_abnormal_nucleus_morphology2.92469880
4MP0003077_abnormal_cell_cycle2.88083244
5MP0010094_abnormal_chromosome_stability2.87178285
6MP0006292_abnormal_olfactory_placode2.81645974
7MP0010352_gastrointestinal_tract_polyps2.50077917
8MP0002396_abnormal_hematopoietic_system2.44501924
9MP0008007_abnormal_cellular_replicative2.21037399
10MP0009379_abnormal_foot_pigmentation2.05663031
11MP0000490_abnormal_crypts_of1.99805781
12MP0003136_yellow_coat_color1.97401865
13MP0003806_abnormal_nucleotide_metabolis1.93989967
14MP0008057_abnormal_DNA_replication1.93503755
15MP0003763_abnormal_thymus_physiology1.89846267
16MP0004808_abnormal_hematopoietic_stem1.84623538
17MP0008058_abnormal_DNA_repair1.84092031
18MP0000350_abnormal_cell_proliferation1.82154236
19MP0009333_abnormal_splenocyte_physiolog1.79725804
20MP0008932_abnormal_embryonic_tissue1.78325948
21MP0001730_embryonic_growth_arrest1.76224426
22MP0003186_abnormal_redox_activity1.76007029
23MP0002938_white_spotting1.70118273
24MP0000566_synostosis1.70012149
25MP0003705_abnormal_hypodermis_morpholog1.65010619
26MP0010030_abnormal_orbit_morphology1.58049469
27MP0002163_abnormal_gland_morphology1.54474299
28MP0006054_spinal_hemorrhage1.51212819
29MP0001545_abnormal_hematopoietic_system1.50758851
30MP0005397_hematopoietic_system_phenotyp1.50758851
31MP0000685_abnormal_immune_system1.48585746
32MP0002398_abnormal_bone_marrow1.45843889
33MP0005076_abnormal_cell_differentiation1.45081025
34MP0003786_premature_aging1.43129385
35MP0000703_abnormal_thymus_morphology1.42762058
36MP0010307_abnormal_tumor_latency1.42749250
37MP0003567_abnormal_fetal_cardiomyocyte1.41651861
38MP0002019_abnormal_tumor_incidence1.40929845
39MP0006035_abnormal_mitochondrial_morpho1.39963640
40MP0009278_abnormal_bone_marrow1.37525333
41MP0002249_abnormal_larynx_morphology1.37086075
42MP0002722_abnormal_immune_system1.37056232
43MP0000678_abnormal_parathyroid_gland1.36791669
44MP0002697_abnormal_eye_size1.35884032
45MP0001697_abnormal_embryo_size1.34322537
46MP0008995_early_reproductive_senescence1.34060518
47MP0004197_abnormal_fetal_growth/weight/1.33543996
48MP0001346_abnormal_lacrimal_gland1.33501708
49MP0003123_paternal_imprinting1.32518110
50MP0002080_prenatal_lethality1.31874126
51MP0006036_abnormal_mitochondrial_physio1.30707363
52MP0005023_abnormal_wound_healing1.29333991
53MP0005380_embryogenesis_phenotype1.29081756
54MP0001672_abnormal_embryogenesis/_devel1.29081756
55MP0000858_altered_metastatic_potential1.28995119
56MP0000689_abnormal_spleen_morphology1.26739973
57MP0000372_irregular_coat_pigmentation1.24983760
58MP0000049_abnormal_middle_ear1.24611116
59MP0005408_hypopigmentation1.24500415
60MP0000313_abnormal_cell_death1.22594167
61MP0003984_embryonic_growth_retardation1.21422256
62MP0003718_maternal_effect1.21284329
63MP0002086_abnormal_extraembryonic_tissu1.21133576
64MP0003566_abnormal_cell_adhesion1.20803108
65MP0001800_abnormal_humoral_immune1.20684933
66MP0002166_altered_tumor_susceptibility1.20409205
67MP0002088_abnormal_embryonic_growth/wei1.20227023
68MP0002085_abnormal_embryonic_tissue1.20032619
69MP0002160_abnormal_reproductive_system1.19420108
70MP0000537_abnormal_urethra_morphology1.19246933
71MP0004185_abnormal_adipocyte_glucose1.19078827
72MP0002084_abnormal_developmental_patter1.18696615
73MP0002210_abnormal_sex_determination1.17884366
74MP0002429_abnormal_blood_cell1.13915585
75MP0009672_abnormal_birth_weight1.12556314
76MP0001286_abnormal_eye_development1.11968585
77MP0005501_abnormal_skin_physiology1.09652611
78MP0000716_abnormal_immune_system1.08438544
79MP0001835_abnormal_antigen_presentation1.06736024
80MP0008789_abnormal_olfactory_epithelium1.06281068
81MP0002405_respiratory_system_inflammati1.05435564
82MP0002132_abnormal_respiratory_system1.04549112
83MP0003300_gastrointestinal_ulcer1.04327656
84MP0009053_abnormal_anal_canal1.04308198
85MP0003938_abnormal_ear_development1.03648850
86MP0003436_decreased_susceptibility_to1.03487915
87MP0010155_abnormal_intestine_physiology1.03445374
88MP0002420_abnormal_adaptive_immunity1.03261849
89MP0002452_abnormal_antigen_presenting1.03012311
90MP0001819_abnormal_immune_cell1.01397514
91MP0003937_abnormal_limbs/digits/tail_de1.01074765
92MP0005394_taste/olfaction_phenotype0.98445297
93MP0005499_abnormal_olfactory_system0.98445297
94MP0002006_tumorigenesis0.95946125
95MP0000465_gastrointestinal_hemorrhage0.95089222
96MP0001849_ear_inflammation0.94626583
97MP0001145_abnormal_male_reproductive0.94537961
98MP0003942_abnormal_urinary_system0.94105286
99MP0001873_stomach_inflammation0.93340039
100MP0000477_abnormal_intestine_morphology0.92561948
101MP0001293_anophthalmia0.92441205
102MP0001853_heart_inflammation0.90567399
103MP0002723_abnormal_immune_serum0.89699410
104MP0000762_abnormal_tongue_morphology0.89263282
105MP0000733_abnormal_muscle_development0.88115139
106MP0003941_abnormal_skin_development0.87918655
107MP0002095_abnormal_skin_pigmentation0.86878874
108MP0010234_abnormal_vibrissa_follicle0.85875885
109MP0001881_abnormal_mammary_gland0.84979274
110MP0005671_abnormal_response_to0.84443688
111MP0004947_skin_inflammation0.82694487
112MP0003866_abnormal_defecation0.82647451
113MP0005451_abnormal_body_composition0.82587310
114MP0009697_abnormal_copulation0.82456674
115MP0002234_abnormal_pharynx_morphology0.82239561
116MP0003303_peritoneal_inflammation0.82130268
117MP0003315_abnormal_perineum_morphology0.80995753
118MP0005000_abnormal_immune_tolerance0.80489438
119MP0005025_abnormal_response_to0.80479403
120MP0004233_abnormal_muscle_weight0.79980866
121MP0002877_abnormal_melanocyte_morpholog0.79310792
122MP0005174_abnormal_tail_pigmentation0.78251193
123MP0002111_abnormal_tail_morphology0.78151036
124MP0000750_abnormal_muscle_regeneration0.77573145
125MP0001929_abnormal_gametogenesis0.77029178
126MP0002233_abnormal_nose_morphology0.76251064
127MP0000653_abnormal_sex_gland0.75814905
128MP0003453_abnormal_keratinocyte_physiol0.74660167
129MP0000358_abnormal_cell_content/0.74454155
130MP0001790_abnormal_immune_system0.73839502
131MP0005387_immune_system_phenotype0.73839502
132MP0002796_impaired_skin_barrier0.73735948
133MP0003448_altered_tumor_morphology0.73409600
134MP0001727_abnormal_embryo_implantation0.72830403
135MP0001216_abnormal_epidermal_layer0.72296444
136MP0001915_intracranial_hemorrhage0.71579492
137MP0005075_abnormal_melanosome_morpholog0.71391132
138MP0002060_abnormal_skin_morphology0.71349487
139MP0009785_altered_susceptibility_to0.69291626
140MP0009931_abnormal_skin_appearance0.69262298
141MP0002092_abnormal_eye_morphology0.68710403
142MP0005389_reproductive_system_phenotype0.68538816
143MP0003385_abnormal_body_wall0.67305385
144MP0001919_abnormal_reproductive_system0.66921634
145MP0002932_abnormal_joint_morphology0.66093705
146MP0003119_abnormal_digestive_system0.65780745
147MP0001661_extended_life_span0.65639847
148MP0009250_abnormal_appendicular_skeleto0.65283936
149MP0001529_abnormal_vocalization0.64734032
150MP0001340_abnormal_eyelid_morphology0.63029635
151MP0000428_abnormal_craniofacial_morphol0.62435426
152MP0001186_pigmentation_phenotype0.61747259
153MP0003755_abnormal_palate_morphology0.61224499

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.80605887
2Abnormal number of erythroid precursors (HP:0012131)7.02873804
3Reticulocytopenia (HP:0001896)6.96663037
4* Macrocytic anemia (HP:0001972)4.55798685
5* Pallor (HP:0000980)4.38245942
6Abnormal mitochondria in muscle tissue (HP:0008316)3.99784973
7Acute necrotizing encephalopathy (HP:0006965)3.97590497
8Increased hepatocellular lipid droplets (HP:0006565)3.67644551
9Thrombocytosis (HP:0001894)3.57432196
10Acute encephalopathy (HP:0006846)3.56325195
11Mitochondrial inheritance (HP:0001427)3.45293236
12Lipid accumulation in hepatocytes (HP:0006561)3.40692962
13Colon cancer (HP:0003003)3.36744489
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34107825
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34107825
16Microvesicular hepatic steatosis (HP:0001414)3.19547367
17Increased CSF lactate (HP:0002490)3.14754957
18Increased intramyocellular lipid droplets (HP:0012240)3.12670772
19Selective tooth agenesis (HP:0001592)3.06444045
20Hepatocellular necrosis (HP:0001404)2.96892016
21Progressive macrocephaly (HP:0004481)2.95184213
22Multiple enchondromatosis (HP:0005701)2.92816664
23Respiratory difficulties (HP:0002880)2.89540751
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88068798
25Abnormality of reticulocytes (HP:0004312)2.86701624
26Trismus (HP:0000211)2.86113185
27Aplastic anemia (HP:0001915)2.80914683
28Renal Fanconi syndrome (HP:0001994)2.78312165
29Cerebral edema (HP:0002181)2.76433821
30Progressive muscle weakness (HP:0003323)2.76038099
31Increased muscle lipid content (HP:0009058)2.75584296
32Partial duplication of thumb phalanx (HP:0009944)2.73427137
33Chromsome breakage (HP:0040012)2.69413744
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63858835
35Hepatic necrosis (HP:0002605)2.63274643
3611 pairs of ribs (HP:0000878)2.63093404
37Absent thumb (HP:0009777)2.62428646
38Oral leukoplakia (HP:0002745)2.59850740
39IgM deficiency (HP:0002850)2.49963433
40Basal cell carcinoma (HP:0002671)2.48839887
41Partial duplication of the phalanx of hand (HP:0009999)2.47076606
42Duplication of thumb phalanx (HP:0009942)2.46628332
43Abnormal hemoglobin (HP:0011902)2.43609899
44Exercise intolerance (HP:0003546)2.41457355
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41066126
46Increased serum lactate (HP:0002151)2.39106112
47Lactic acidosis (HP:0003128)2.31423703
48Carpal bone hypoplasia (HP:0001498)2.29233484
49Broad distal phalanx of finger (HP:0009836)2.24015916
50Microretrognathia (HP:0000308)2.20777773
51Missing ribs (HP:0000921)2.20518659
52Ependymoma (HP:0002888)2.16892050
53Breast hypoplasia (HP:0003187)2.15185034
54Neoplasm of the pancreas (HP:0002894)2.13685111
55Birth length less than 3rd percentile (HP:0003561)2.10000013
56Abnormality of cochlea (HP:0000375)2.08077030
57Atresia of the external auditory canal (HP:0000413)2.07569935
58Patellar aplasia (HP:0006443)2.07102569
59Facial cleft (HP:0002006)2.04553972
60Increased density of long bones (HP:0006392)2.04078581
61Pancytopenia (HP:0001876)2.03937780
62Abnormality of the anterior horn cell (HP:0006802)2.03581768
63Degeneration of anterior horn cells (HP:0002398)2.03581768
64Rough bone trabeculation (HP:0100670)2.02116196
65Abnormality of glycolysis (HP:0004366)2.02039682
66Elevated erythrocyte sedimentation rate (HP:0003565)2.01509259
67Protrusio acetabuli (HP:0003179)2.01424359
68Poikiloderma (HP:0001029)2.01251458
69Myelodysplasia (HP:0002863)1.99180514
70Aplasia/Hypoplasia of the patella (HP:0006498)1.98703539
71Abnormal number of incisors (HP:0011064)1.98640546
72Proximal placement of thumb (HP:0009623)1.98104438
73Respiratory failure (HP:0002878)1.97902394
74Overlapping toe (HP:0001845)1.97210129
75Testicular atrophy (HP:0000029)1.96719513
76* Depressed nasal ridge (HP:0000457)1.95609336
77Medulloblastoma (HP:0002885)1.94379295
78Deviation of the thumb (HP:0009603)1.91815754
79Increased serum pyruvate (HP:0003542)1.91336990
80Bicuspid aortic valve (HP:0001647)1.91186803
81Recurrent bronchitis (HP:0002837)1.91032515
82Leukodystrophy (HP:0002415)1.89712011
83Abnormality of DNA repair (HP:0003254)1.89287296
84Stenosis of the external auditory canal (HP:0000402)1.89122936
85Rectal prolapse (HP:0002035)1.85720593
863-Methylglutaconic aciduria (HP:0003535)1.85646121
87Truncus arteriosus (HP:0001660)1.84798390
88Type I transferrin isoform profile (HP:0003642)1.83664615
89Petechiae (HP:0000967)1.83269305
90Ragged-red muscle fibers (HP:0003200)1.83171328
91Asplenia (HP:0001746)1.81997568
92Exertional dyspnea (HP:0002875)1.81772022
93Glossoptosis (HP:0000162)1.81267373
94Abnormality of T cells (HP:0002843)1.80354846
95Hyperacusis (HP:0010780)1.78664499
96Chronic otitis media (HP:0000389)1.78057363
97* Thick lower lip vermilion (HP:0000179)1.77834040
98Squamous cell carcinoma (HP:0002860)1.76419823
99Lymphoma (HP:0002665)1.76143603
100Amaurosis fugax (HP:0100576)1.75567869
101Abnormality of T cell physiology (HP:0011840)1.75199079
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74265443
103Reduced antithrombin III activity (HP:0001976)1.73955394
104Septo-optic dysplasia (HP:0100842)1.73746513
105Nasolacrimal duct obstruction (HP:0000579)1.73187140
106Slender long bone (HP:0003100)1.72403062
107Premature graying of hair (HP:0002216)1.72146335
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.71673791
109Gout (HP:0001997)1.71260125
110Hypoplasia of the radius (HP:0002984)1.70865599
111Seborrheic dermatitis (HP:0001051)1.70088638
112Ankle contracture (HP:0006466)1.69952261
113Rhabdomyosarcoma (HP:0002859)1.69718112
114Nasal polyposis (HP:0100582)1.69596031
115Abnormality of the parietal bone (HP:0002696)1.69134546
116Mesangial abnormality (HP:0001966)1.68857366
117Recurrent viral infections (HP:0004429)1.68202091
118Triphalangeal thumb (HP:0001199)1.67280596
119Preauricular skin tag (HP:0000384)1.67255819
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.66593323
121Woolly hair (HP:0002224)1.65895406
122Tracheoesophageal fistula (HP:0002575)1.64938441
123Skin tags (HP:0010609)1.64386388
124* Migraine (HP:0002076)1.62988549
125Cellulitis (HP:0100658)1.61986020
126Premature ovarian failure (HP:0008209)1.60636019
127Short thumb (HP:0009778)1.60229815
128Abnormality of the calcaneus (HP:0008364)1.58825601
129Angiofibromas (HP:0010615)1.58768149
130Adenoma sebaceum (HP:0009720)1.58768149
131Cleft eyelid (HP:0000625)1.58593537
132Agnosia (HP:0010524)1.57780632
133Septate vagina (HP:0001153)1.57644651
134Sensory axonal neuropathy (HP:0003390)1.57609024
135Morphological abnormality of the inner ear (HP:0011390)1.57099091
136Panhypogammaglobulinemia (HP:0003139)1.57001128
137Deep palmar crease (HP:0006191)1.56684803
138Hypoplastic pelvis (HP:0008839)1.56652980
139Pustule (HP:0200039)1.56353280
140Maternal diabetes (HP:0009800)1.56034598
141Aplasia/Hypoplasia of the thymus (HP:0010515)1.55957757
142Hyperthyroidism (HP:0000836)1.55742555
143T lymphocytopenia (HP:0005403)1.55030351
144Meckel diverticulum (HP:0002245)1.54047128
145Abnormality of the nasal mucosa (HP:0000433)1.53399872
146Papilloma (HP:0012740)1.52973055
147Verrucae (HP:0200043)1.52973055
148High anterior hairline (HP:0009890)1.52887067
149Cellular immunodeficiency (HP:0005374)1.52611230
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52457489
151Vertebral hypoplasia (HP:0008417)1.52457489
152Increased nuchal translucency (HP:0010880)1.51553070
153Entropion (HP:0000621)1.51206997
154Sparse lateral eyebrow (HP:0005338)1.50416339
155Horseshoe kidney (HP:0000085)1.50365930
156Broad palm (HP:0001169)1.48451170
157Abnormality of the preputium (HP:0100587)1.48144728
158Congenital, generalized hypertrichosis (HP:0004540)1.47641190
159Abnormality of the ileum (HP:0001549)1.47599452
160Absent radius (HP:0003974)1.45692640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48457607
2NME24.05952884
3EEF2K3.64147809
4SMG13.12243901
5BUB12.72663361
6WEE12.67653418
7PKN22.59988551
8RPS6KB22.52884262
9LRRK22.48200993
10MAP3K102.39313640
11MAP4K12.36399296
12PBK2.33295469
13CDC72.30140887
14NEK22.18268933
15TRIB32.17744035
16NME12.06815020
17TLK11.92220754
18PASK1.88994906
19TESK21.83304428
20RPS6KA41.77556433
21TAF11.75256360
22STK101.74012881
23TGFBR11.68584351
24ARAF1.64079148
25PIM21.63018289
26CDK191.60090655
27ZAK1.58965120
28IRAK31.58223318
29FLT31.54690167
30DYRK31.50294398
31BRAF1.47750215
32PAK41.47371520
33CDK71.44459335
34CDK121.42950018
35SCYL21.40723877
36EIF2AK11.37527630
37MAP3K81.35656785
38ERN11.31685123
39CDK41.31361800
40SRPK11.31144668
41CDK81.31053938
42EPHA21.30635474
43MAPKAPK31.26332333
44ICK1.24252119
45ILK1.24149537
46PIM11.16793530
47* AURKB1.16494479
48VRK11.13075699
49ACVR1B1.11654977
50KDR1.10899953
51ZAP701.10685138
52BRSK21.09730615
53TSSK61.09508639
54GRK61.08523909
55TTK1.07732920
56BTK1.07524525
57PLK11.04979569
58ATR1.01718205
59MAP2K31.00421991
60NEK11.00274710
61MKNK10.99405394
62BCKDK0.93912617
63MST40.93623911
64PRPF4B0.93479049
65STK40.89825502
66CDK60.87295570
67MAP3K110.86857709
68TESK10.86233481
69EIF2AK30.81355659
70TYK20.80992535
71STK160.80742270
72JAK30.80500701
73PLK30.76958749
74AURKA0.76636742
75PAK20.75319138
76DYRK20.74566552
77PTK60.74299369
78CHEK10.73917122
79ABL20.73542755
80ALK0.71672317
81BLK0.70332047
82MAP2K20.69156249
83PAK10.66565295
84MAP3K30.65618088
85TTN0.65299048
86CSF1R0.64494004
87TEC0.62326898
88CHEK20.61172260
89PDK20.60416176
90IKBKB0.59265057
91SIK10.57930061
92RPS6KA50.57530617
93KIT0.57388102
94MTOR0.56588578
95* CSNK2A20.55640317
96IRAK20.51480464
97CDK20.51351984
98TBK10.51093527
99PRKCI0.48357777
100NLK0.47789666
101BRSK10.47061994
102DAPK30.46611327
103PLK40.46538542
104DYRK1B0.46403369
105CDK10.45898652
106BMX0.45233411
107CSNK2A10.44972067
108MARK30.44626163
109MKNK20.43889295
110MAPKAPK20.43383690
111ATM0.42826100
112RPS6KL10.42519470
113RPS6KC10.42519470
114TAOK20.42377947
115RPS6KA60.42053777
116ITK0.41128858
117LCK0.39786602
118SYK0.39538266
119CHUK0.39152832
120BRD40.38901691
121RPS6KA10.38871219
122CLK10.38855842
123CDK11A0.38253255
124AKT20.37950051
125CCNB10.37383370
126EPHB20.35960444
127CSNK1E0.34976160
128MELK0.34178426
129TYRO30.33697159
130LATS20.29758036
131CDK90.25803109
132DAPK10.25479099
133MAPKAPK50.25444448

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.44263100
2DNA replication_Homo sapiens_hsa030304.09856617
3Mismatch repair_Homo sapiens_hsa034303.34663739
4Spliceosome_Homo sapiens_hsa030403.09303138
5Oxidative phosphorylation_Homo sapiens_hsa001903.04687497
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65882532
7RNA transport_Homo sapiens_hsa030132.50277461
8Base excision repair_Homo sapiens_hsa034102.47935010
9Proteasome_Homo sapiens_hsa030502.46623980
10RNA polymerase_Homo sapiens_hsa030202.43678746
11Nucleotide excision repair_Homo sapiens_hsa034202.36038795
12Homologous recombination_Homo sapiens_hsa034402.24372821
13One carbon pool by folate_Homo sapiens_hsa006702.19729945
14Pyrimidine metabolism_Homo sapiens_hsa002401.98735348
15Cell cycle_Homo sapiens_hsa041101.98013804
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93824187
17Alzheimers disease_Homo sapiens_hsa050101.77310349
18p53 signaling pathway_Homo sapiens_hsa041151.56236776
19Non-homologous end-joining_Homo sapiens_hsa034501.47729243
20Fanconi anemia pathway_Homo sapiens_hsa034601.45827458
21RNA degradation_Homo sapiens_hsa030181.43170923
22Primary immunodeficiency_Homo sapiens_hsa053401.42355288
23Antigen processing and presentation_Homo sapiens_hsa046121.37193858
24mRNA surveillance pathway_Homo sapiens_hsa030151.34228280
25Systemic lupus erythematosus_Homo sapiens_hsa053221.21055480
26Sulfur relay system_Homo sapiens_hsa041221.16933098
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16405169
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14480996
29Epstein-Barr virus infection_Homo sapiens_hsa051691.14153308
30Herpes simplex infection_Homo sapiens_hsa051681.13921925
31Viral carcinogenesis_Homo sapiens_hsa052031.05766197
32Cardiac muscle contraction_Homo sapiens_hsa042601.04784421
33Basal transcription factors_Homo sapiens_hsa030221.01198622
34Carbon metabolism_Homo sapiens_hsa012001.00045268
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99849249
36HTLV-I infection_Homo sapiens_hsa051660.97834990
37Small cell lung cancer_Homo sapiens_hsa052220.97283740
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.96046602
39Thyroid cancer_Homo sapiens_hsa052160.92537693
40Pyruvate metabolism_Homo sapiens_hsa006200.91645948
41Chronic myeloid leukemia_Homo sapiens_hsa052200.87863124
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86737396
43Acute myeloid leukemia_Homo sapiens_hsa052210.82711010
44Pentose phosphate pathway_Homo sapiens_hsa000300.82363291
45Vitamin B6 metabolism_Homo sapiens_hsa007500.79712341
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79415567
47Legionellosis_Homo sapiens_hsa051340.78476349
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77982024
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77615485
50Apoptosis_Homo sapiens_hsa042100.77169025
51Purine metabolism_Homo sapiens_hsa002300.76841930
52Measles_Homo sapiens_hsa051620.76545122
53Bladder cancer_Homo sapiens_hsa052190.76526248
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.76336129
55Notch signaling pathway_Homo sapiens_hsa043300.75908862
56MicroRNAs in cancer_Homo sapiens_hsa052060.72472829
57Protein export_Homo sapiens_hsa030600.70943587
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70436829
59Hematopoietic cell lineage_Homo sapiens_hsa046400.69686471
60Shigellosis_Homo sapiens_hsa051310.69427411
61Folate biosynthesis_Homo sapiens_hsa007900.65434306
62B cell receptor signaling pathway_Homo sapiens_hsa046620.65094318
63Leishmaniasis_Homo sapiens_hsa051400.63664009
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63334975
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62894961
66Fructose and mannose metabolism_Homo sapiens_hsa000510.62587480
67Hepatitis B_Homo sapiens_hsa051610.62210055
68Basal cell carcinoma_Homo sapiens_hsa052170.61694842
69Fatty acid elongation_Homo sapiens_hsa000620.60386287
70Metabolic pathways_Homo sapiens_hsa011000.58888986
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57252840
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.57123615
73Biosynthesis of amino acids_Homo sapiens_hsa012300.56024199
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55460260
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.53811420
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53750062
77Colorectal cancer_Homo sapiens_hsa052100.53196797
78N-Glycan biosynthesis_Homo sapiens_hsa005100.52875077
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52786399
80Viral myocarditis_Homo sapiens_hsa054160.51994421
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51099885
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.50103718
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.49979111
84Toxoplasmosis_Homo sapiens_hsa051450.48927370
85T cell receptor signaling pathway_Homo sapiens_hsa046600.48725050
86TGF-beta signaling pathway_Homo sapiens_hsa043500.48134151
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47270202
88HIF-1 signaling pathway_Homo sapiens_hsa040660.47093846
89Selenocompound metabolism_Homo sapiens_hsa004500.46150106
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.44830829
91Huntingtons disease_Homo sapiens_hsa050160.44722550
92Parkinsons disease_Homo sapiens_hsa050120.44220860
93Pathways in cancer_Homo sapiens_hsa052000.44000585
94Proteoglycans in cancer_Homo sapiens_hsa052050.43417048
95Hippo signaling pathway_Homo sapiens_hsa043900.43396593
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43094580
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42889966
98Influenza A_Homo sapiens_hsa051640.42171875
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41117996
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40936082
101Glutathione metabolism_Homo sapiens_hsa004800.40684447
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40341304
103Non-small cell lung cancer_Homo sapiens_hsa052230.38165308
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36495247
105Adherens junction_Homo sapiens_hsa045200.36216591
106Arginine and proline metabolism_Homo sapiens_hsa003300.35821723
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.35558635
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33913513
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33127054
110Pancreatic cancer_Homo sapiens_hsa052120.32114901
111Alcoholism_Homo sapiens_hsa050340.31477537
112Osteoclast differentiation_Homo sapiens_hsa043800.29260304
113Prostate cancer_Homo sapiens_hsa052150.28006934
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27933366
115mTOR signaling pathway_Homo sapiens_hsa041500.27213108
116Hedgehog signaling pathway_Homo sapiens_hsa043400.25867268
117Galactose metabolism_Homo sapiens_hsa000520.24956199
118Vitamin digestion and absorption_Homo sapiens_hsa049770.24079588
119Wnt signaling pathway_Homo sapiens_hsa043100.23243254
120Steroid biosynthesis_Homo sapiens_hsa001000.22102054
121Oocyte meiosis_Homo sapiens_hsa041140.22101768
122Tyrosine metabolism_Homo sapiens_hsa003500.21744013
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18756848
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16393290
125Arginine biosynthesis_Homo sapiens_hsa002200.15602747
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14825614
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11394005
128Melanoma_Homo sapiens_hsa052180.08257025
129Fat digestion and absorption_Homo sapiens_hsa049750.06786611
130Lysine degradation_Homo sapiens_hsa003100.05023155
131Sulfur metabolism_Homo sapiens_hsa009200.04919737
132Phenylalanine metabolism_Homo sapiens_hsa003600.04674091

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