RPS10-NUDT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring RPS10 (ribosomal protein S10) and NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) genes on chromosome 6. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.63573043
2regulation of RNA export from nucleus (GO:0046831)4.20479558
3mitotic chromosome condensation (GO:0007076)4.10630138
4DNA unwinding involved in DNA replication (GO:0006268)4.06734090
53-UTR-mediated mRNA stabilization (GO:0070935)3.90779730
6nuclear pore organization (GO:0006999)3.72509676
7DNA topological change (GO:0006265)3.67737738
8regulation of nucleobase-containing compound transport (GO:0032239)3.63392533
9mRNA stabilization (GO:0048255)3.60850555
10RNA stabilization (GO:0043489)3.60850555
11spliceosomal tri-snRNP complex assembly (GO:0000244)3.57055749
12formation of translation preinitiation complex (GO:0001731)3.56852570
13ribosome assembly (GO:0042255)3.53402674
14histone H2B ubiquitination (GO:0033523)3.51086492
15pore complex assembly (GO:0046931)3.48200621
16protein localization to endosome (GO:0036010)3.47319785
17regulation of translational fidelity (GO:0006450)3.43458945
18mitochondrial fusion (GO:0008053)3.40526152
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.32346647
20peptidyl-arginine omega-N-methylation (GO:0035247)3.31310578
21pentose-phosphate shunt (GO:0006098)3.29650481
22negative regulation of erythrocyte differentiation (GO:0045647)3.08603035
23establishment of integrated proviral latency (GO:0075713)3.08028735
24protein maturation by protein folding (GO:0022417)3.07164016
25response to peptidoglycan (GO:0032494)3.02523480
26protein localization to chromosome, centromeric region (GO:0071459)3.01203597
27ribosome biogenesis (GO:0042254)3.00113633
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98722652
29nucleosome disassembly (GO:0006337)2.92842930
30protein-DNA complex disassembly (GO:0032986)2.92842930
31peptidyl-arginine N-methylation (GO:0035246)2.90920582
32peptidyl-arginine methylation (GO:0018216)2.90920582
33maturation of SSU-rRNA (GO:0030490)2.88344756
34positive regulation of DNA-templated transcription, elongation (GO:0032786)2.83733770
35mitotic metaphase plate congression (GO:0007080)2.83386073
36COPI coating of Golgi vesicle (GO:0048205)2.82851572
37Golgi transport vesicle coating (GO:0048200)2.82851572
38viral mRNA export from host cell nucleus (GO:0046784)2.82412676
39NADPH regeneration (GO:0006740)2.80840190
40NIK/NF-kappaB signaling (GO:0038061)2.79544685
41ribosomal small subunit biogenesis (GO:0042274)2.79040715
42regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.77949411
43mRNA transcription from RNA polymerase II promoter (GO:0042789)2.75387178
44pinocytosis (GO:0006907)2.74146804
45ribonucleoprotein complex biogenesis (GO:0022613)2.69431144
46folic acid-containing compound biosynthetic process (GO:0009396)2.69147320
47mitotic sister chromatid cohesion (GO:0007064)2.67561785
48establishment of viral latency (GO:0019043)2.60483599
49regulation of superoxide anion generation (GO:0032928)2.60179502
50regulation of translational termination (GO:0006449)2.59944887
51regulation of RIG-I signaling pathway (GO:0039535)2.58643888
52histone arginine methylation (GO:0034969)2.58643537
53regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57974620
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57635669
55DNA replication initiation (GO:0006270)2.56785279
56corticosteroid receptor signaling pathway (GO:0031958)2.56056632
57protein complex localization (GO:0031503)2.55327565
58negative regulation of mRNA metabolic process (GO:1903312)2.53884185
59mRNA transcription (GO:0009299)2.53327738
60regulation of mRNA stability (GO:0043488)2.53162066
61heterochromatin organization (GO:0070828)2.52904764
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.52816815
63negative regulation of mRNA processing (GO:0050686)2.51864846
64DNA strand elongation involved in DNA replication (GO:0006271)2.50652508
65DNA strand elongation (GO:0022616)2.49430412
66embryonic process involved in female pregnancy (GO:0060136)2.48444089
67negative regulation of histone methylation (GO:0031061)2.47366675
68regulation of RNA stability (GO:0043487)2.47166951
69glucocorticoid receptor signaling pathway (GO:0042921)2.46951657
70glucose 6-phosphate metabolic process (GO:0051156)2.45061021
71positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.44801782
72regulation of transcription from RNA polymerase I promoter (GO:0006356)2.43874665
73sister chromatid segregation (GO:0000819)2.42923173
74dosage compensation (GO:0007549)2.40652225
75mitotic sister chromatid segregation (GO:0000070)2.40464341
76proline biosynthetic process (GO:0006561)2.39018173
77rRNA transcription (GO:0009303)2.38840624
78response to muramyl dipeptide (GO:0032495)2.38260806
79glucose catabolic process (GO:0006007)2.37709676
80regulation of histone H3-K9 methylation (GO:0051570)2.35969268
81chromosome condensation (GO:0030261)2.35613891
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34816659
83DNA duplex unwinding (GO:0032508)2.34795312
84regulation of histone H3-K27 methylation (GO:0061085)2.34299796
85protein export from nucleus (GO:0006611)2.34019202
86RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.34009577
87mRNA splicing, via spliceosome (GO:0000398)2.34009577
88nucleobase-containing small molecule interconversion (GO:0015949)2.33035339
89cellular protein complex localization (GO:0034629)2.32540347
90chromatin assembly (GO:0031497)2.30485104
91IMP metabolic process (GO:0046040)2.29456358
92establishment of chromosome localization (GO:0051303)2.28695357
93intracellular estrogen receptor signaling pathway (GO:0030520)2.28387023
94regulation of NFAT protein import into nucleus (GO:0051532)2.27619388
95negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.27549794
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.27206407
97RNA splicing, via transesterification reactions (GO:0000375)2.26886722
98regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.26275089
99positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.26275089
100peptidyl-threonine dephosphorylation (GO:0035970)2.25872342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10909919
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58745078
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.49579911
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.40148119
5MYC_22102868_ChIP-Seq_BL_Human3.11566725
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.04292536
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91748766
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50414359
9VDR_21846776_ChIP-Seq_THP-1_Human2.36288768
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24692963
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14423257
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14056668
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11730230
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.09585677
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04710276
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94832127
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94614924
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94084469
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85222921
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82512395
21ZNF263_19887448_ChIP-Seq_K562_Human1.80086675
22ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76246199
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76179431
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.74335161
25XRN2_22483619_ChIP-Seq_HELA_Human1.72407003
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71689443
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68062200
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65764600
29TCF7_22412390_ChIP-Seq_EML_Mouse1.58992356
30KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54483726
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54355299
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51965621
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51200812
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50532400
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50020188
36CLOCK_20551151_ChIP-Seq_293T_Human1.49742221
37AR_21909140_ChIP-Seq_LNCAP_Human1.47335075
38MAF_26560356_Chip-Seq_TH1_Human1.45829725
39HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43273152
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42866873
41CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42225732
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41395779
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41376387
44DCP1A_22483619_ChIP-Seq_HELA_Human1.41179193
45TFEB_21752829_ChIP-Seq_HELA_Human1.40875972
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.40477272
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40436213
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37783052
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35717139
50NCOR1_26117541_ChIP-Seq_K562_Human1.34439226
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33000130
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29456139
53SPI1_23547873_ChIP-Seq_NB4_Human1.29221072
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28932863
55KDM2B_26808549_Chip-Seq_DND41_Human1.28253561
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27574987
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25749400
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25694849
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25472477
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25447916
61VDR_24763502_ChIP-Seq_THP-1_Human1.25307687
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.23614144
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.23061662
64TTF2_22483619_ChIP-Seq_HELA_Human1.22228564
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21925666
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21347445
67RACK7_27058665_Chip-Seq_MCF-7_Human1.21340848
68UTX_26944678_Chip-Seq_JUKART_Human1.21121072
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20953863
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20194930
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19591518
72LXR_22292898_ChIP-Seq_THP-1_Human1.19579219
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19236612
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.18782030
75CIITA_25753668_ChIP-Seq_RAJI_Human1.18709022
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17841397
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16603206
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14978134
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14011899
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13743722
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13313323
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12267369
83GABP_19822575_ChIP-Seq_HepG2_Human1.12215926
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12167630
85ATF3_27146783_Chip-Seq_COLON_Human1.10893296
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10312437
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09565732
88MAF_26560356_Chip-Seq_TH2_Human1.09553643
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09089179
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08665443
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08300876
92KDM5A_27292631_Chip-Seq_BREAST_Human1.08128080
93GATA1_22025678_ChIP-Seq_K562_Human1.03956650
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03838675
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02089192
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01369034
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00901712
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00120259
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00111958
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00083620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.68008688
2MP0005451_abnormal_body_composition3.18978451
3MP0003303_peritoneal_inflammation3.06721698
4MP0003705_abnormal_hypodermis_morpholog2.99150600
5MP0003693_abnormal_embryo_hatching2.85430779
6MP0003111_abnormal_nucleus_morphology2.67537554
7MP0004957_abnormal_blastocyst_morpholog2.55574419
8MP0005076_abnormal_cell_differentiation2.44447787
9MP0010094_abnormal_chromosome_stability2.39196418
10MP0005058_abnormal_lysosome_morphology2.17845035
11MP0003077_abnormal_cell_cycle2.17179619
12MP0003221_abnormal_cardiomyocyte_apopto2.12923147
13MP0004185_abnormal_adipocyte_glucose2.10561372
14MP0001730_embryonic_growth_arrest2.03421333
15MP0009278_abnormal_bone_marrow1.93574599
16MP0004510_myositis1.90323198
17MP0004233_abnormal_muscle_weight1.89547904
18MP0008260_abnormal_autophagy1.87036165
19MP0004808_abnormal_hematopoietic_stem1.78669001
20MP0000747_muscle_weakness1.76736045
21MP0002396_abnormal_hematopoietic_system1.76368711
22MP0003566_abnormal_cell_adhesion1.75482713
23MP0000537_abnormal_urethra_morphology1.67292741
24MP0010352_gastrointestinal_tract_polyps1.66394464
25MP0003436_decreased_susceptibility_to1.58618082
26MP0000350_abnormal_cell_proliferation1.56987426
27MP0000858_altered_metastatic_potential1.54964674
28MP0003300_gastrointestinal_ulcer1.43442007
29MP0002009_preneoplasia1.42514377
30MP0003453_abnormal_keratinocyte_physiol1.42228739
31MP0005464_abnormal_platelet_physiology1.42127679
32MP0010307_abnormal_tumor_latency1.42085406
33MP0009333_abnormal_splenocyte_physiolog1.39490661
34MP0000313_abnormal_cell_death1.39201688
35MP0009672_abnormal_birth_weight1.38950140
36MP0002080_prenatal_lethality1.38222881
37MP0001835_abnormal_antigen_presentation1.37249939
38MP0008932_abnormal_embryonic_tissue1.36173074
39MP0009840_abnormal_foam_cell1.35713027
40MP0000490_abnormal_crypts_of1.35025107
41MP0000750_abnormal_muscle_regeneration1.34240139
42MP0001727_abnormal_embryo_implantation1.32797888
43MP0008058_abnormal_DNA_repair1.30085938
44MP0002796_impaired_skin_barrier1.29233102
45MP0003315_abnormal_perineum_morphology1.28369688
46MP0001545_abnormal_hematopoietic_system1.27923568
47MP0005397_hematopoietic_system_phenotyp1.27923568
48MP0005501_abnormal_skin_physiology1.25628359
49MP0008007_abnormal_cellular_replicative1.23739488
50MP0004947_skin_inflammation1.23616459
51MP0001672_abnormal_embryogenesis/_devel1.23589939
52MP0005380_embryogenesis_phenotype1.23589939
53MP0002419_abnormal_innate_immunity1.21925314
54MP0003984_embryonic_growth_retardation1.21127198
55MP0002398_abnormal_bone_marrow1.18672890
56MP0008438_abnormal_cutaneous_collagen1.16275665
57MP0005000_abnormal_immune_tolerance1.15934479
58MP0000358_abnormal_cell_content/1.14368367
59MP0003448_altered_tumor_morphology1.13690964
60MP0002088_abnormal_embryonic_growth/wei1.13516858
61MP0002086_abnormal_extraembryonic_tissu1.12562003
62MP0000685_abnormal_immune_system1.11747741
63MP0002452_abnormal_antigen_presenting1.11065558
64MP0003091_abnormal_cell_migration1.10910992
65MP0001849_ear_inflammation1.10375779
66MP0001697_abnormal_embryo_size1.10110137
67MP0010234_abnormal_vibrissa_follicle1.08053219
68MP0000759_abnormal_skeletal_muscle1.07037106
69MP0005621_abnormal_cell_physiology1.02315415
70MP0004087_abnormal_muscle_fiber1.01868699
71MP0002429_abnormal_blood_cell1.01626189
72MP0002019_abnormal_tumor_incidence1.00909094
73MP0002332_abnormal_exercise_endurance1.00706313
74MP0005384_cellular_phenotype1.00567983
75MP0003806_abnormal_nucleotide_metabolis1.00381086
76MP0002148_abnormal_hypersensitivity_rea1.00247028
77MP0005025_abnormal_response_to0.99538422
78MP0002722_abnormal_immune_system0.99135479
79MP0000733_abnormal_muscle_development0.99121672
80MP0003828_pulmonary_edema0.98978814
81MP0002420_abnormal_adaptive_immunity0.98281344
82MP0001819_abnormal_immune_cell0.96588053
83MP0005666_abnormal_adipose_tissue0.94815827
84MP0003656_abnormal_erythrocyte_physiolo0.93255808
85MP0010630_abnormal_cardiac_muscle0.93090918
86MP0001790_abnormal_immune_system0.92654162
87MP0005387_immune_system_phenotype0.92654162
88MP0002269_muscular_atrophy0.92592759
89MP0000703_abnormal_thymus_morphology0.92553290
90MP0009785_altered_susceptibility_to0.91728714
91MP0002723_abnormal_immune_serum0.91347817
92MP0000716_abnormal_immune_system0.90297863
93MP0001881_abnormal_mammary_gland0.89398898
94MP0001800_abnormal_humoral_immune0.87874984
95MP0000689_abnormal_spleen_morphology0.87872173
96MP0004272_abnormal_basement_membrane0.87026662
97MP0004197_abnormal_fetal_growth/weight/0.85713533
98MP0001853_heart_inflammation0.84214283
99MP0000751_myopathy0.84017292
100MP0008057_abnormal_DNA_replication0.83737677

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.63057559
2Progressive muscle weakness (HP:0003323)3.49635607
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.40427033
4Insomnia (HP:0100785)3.04888773
5Increased connective tissue (HP:0009025)2.94274845
6Achilles tendon contracture (HP:0001771)2.87804242
7Pelvic girdle muscle weakness (HP:0003749)2.86806711
8Shoulder girdle muscle weakness (HP:0003547)2.82055000
9Fatigue (HP:0012378)2.66163150
10Abnormal gallbladder physiology (HP:0012438)2.61500987
11Cholecystitis (HP:0001082)2.61500987
12Spastic diplegia (HP:0001264)2.58305882
13Distal lower limb amyotrophy (HP:0008944)2.56460129
14Ragged-red muscle fibers (HP:0003200)2.53021351
15Difficulty climbing stairs (HP:0003551)2.50912925
16Nemaline bodies (HP:0003798)2.48384233
17Multiple enchondromatosis (HP:0005701)2.48082941
18Cellulitis (HP:0100658)2.44919441
19Abnormality of the Achilles tendon (HP:0005109)2.43395281
20Calcaneovalgus deformity (HP:0001848)2.41297879
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.38513425
22Progressive external ophthalmoplegia (HP:0000590)2.35675890
23Overriding aorta (HP:0002623)2.35357707
24Abnormality of skeletal muscle fiber size (HP:0012084)2.30691573
25Abnormality of the calcaneus (HP:0008364)2.29457663
26Muscle fiber inclusion bodies (HP:0100299)2.26952432
27Thrombocytosis (HP:0001894)2.25498988
28Insidious onset (HP:0003587)2.23770541
29Termporal pattern (HP:0011008)2.23770541
30Trismus (HP:0000211)2.19429219
31Orthostatic hypotension (HP:0001278)2.15419192
32Upper limb muscle weakness (HP:0003484)2.14140269
33Abnormality of the musculature of the pelvis (HP:0001469)2.11710573
34Abnormality of the hip-girdle musculature (HP:0001445)2.11710573
35Sparse lateral eyebrow (HP:0005338)2.08996585
36Reticulocytosis (HP:0001923)2.08379422
37Elfin facies (HP:0004428)2.07240919
38Aplastic anemia (HP:0001915)2.06977123
39Increased variability in muscle fiber diameter (HP:0003557)2.06966812
40Distal lower limb muscle weakness (HP:0009053)2.06536788
41Breech presentation (HP:0001623)1.99508910
42Nonimmune hydrops fetalis (HP:0001790)1.98955631
43Microvesicular hepatic steatosis (HP:0001414)1.98437257
44Deformed tarsal bones (HP:0008119)1.98384407
45Dysmetric saccades (HP:0000641)1.95224574
46Abnormality of macrophages (HP:0004311)1.94909947
47Abnormality of reticulocytes (HP:0004312)1.93077551
48Premature rupture of membranes (HP:0001788)1.90844968
49Myopathic facies (HP:0002058)1.90187551
50Ulnar bowing (HP:0003031)1.89850720
51Hypertensive crisis (HP:0100735)1.86140807
52Back pain (HP:0003418)1.85721899
53Type 1 muscle fiber predominance (HP:0003803)1.85569869
54Mediastinal lymphadenopathy (HP:0100721)1.83115483
55Vertebral compression fractures (HP:0002953)1.83104810
56Recurrent viral infections (HP:0004429)1.82647757
57Myocardial infarction (HP:0001658)1.81726032
58Recurrent abscess formation (HP:0002722)1.79349203
59Exercise-induced myalgia (HP:0003738)1.79216052
60Cortical dysplasia (HP:0002539)1.77197325
61Deep palmar crease (HP:0006191)1.75831374
62Eczematoid dermatitis (HP:0000976)1.75179533
63Distal arthrogryposis (HP:0005684)1.73281263
64Lower limb amyotrophy (HP:0007210)1.73171762
65Rough bone trabeculation (HP:0100670)1.72297837
66Patellar dislocation (HP:0002999)1.69799342
67Polycythemia (HP:0001901)1.69562428
68IgM deficiency (HP:0002850)1.69146238
69Long palpebral fissure (HP:0000637)1.68646316
70Increased nuchal translucency (HP:0010880)1.68120516
71Abnormality of glycolipid metabolism (HP:0010969)1.66914712
72Abnormality of liposaccharide metabolism (HP:0010968)1.66914712
73Abnormality of glycosphingolipid metabolism (HP:0004343)1.66914712
74Segmental peripheral demyelination/remyelination (HP:0003481)1.66814148
75Recurrent bacterial skin infections (HP:0005406)1.66577046
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66231598
77Abnormality of the peritoneum (HP:0002585)1.65730012
78Renal duplication (HP:0000075)1.65470030
79Flat cornea (HP:0007720)1.65300755
80Bulbar palsy (HP:0001283)1.64960198
81Asymmetry of the thorax (HP:0001555)1.64641096
82Disproportionate tall stature (HP:0001519)1.64133424
83Syringomyelia (HP:0003396)1.63690430
84Spinal cord lesions (HP:0100561)1.63690430
85Limb-girdle muscle atrophy (HP:0003797)1.62137725
86Deviation of the thumb (HP:0009603)1.62069879
87Reticulocytopenia (HP:0001896)1.60773601
88Petechiae (HP:0000967)1.59200982
89Apathy (HP:0000741)1.59095283
90Hammertoe (HP:0001765)1.58576046
91Round ear (HP:0100830)1.57798585
92Decreased motor nerve conduction velocity (HP:0003431)1.55158284
93Obstructive lung disease (HP:0006536)1.54617408
94Chronic obstructive pulmonary disease (HP:0006510)1.54617408
95Diminished motivation (HP:0000745)1.53726193
96Progressive hearing impairment (HP:0001730)1.53049983
97Protrusio acetabuli (HP:0003179)1.53029574
98EMG: myopathic abnormalities (HP:0003458)1.52202660
99Deep philtrum (HP:0002002)1.51398530
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.51358373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.68193539
2IRAK33.55047460
3TRIB33.22047926
4NME22.81829660
5SMG12.76947417
6ICK2.36081582
7PRPF4B2.35364770
8EEF2K2.15140170
9SRPK11.99321459
10TAOK21.99039123
11LATS21.95073463
12MAP3K101.90179915
13MAP3K141.88090048
14TSSK61.84491905
15SCYL21.80631112
16MAP2K31.67211567
17CDC71.63089678
18ALK1.53500268
19MAP3K111.52590689
20MOS1.49791756
21PKN21.42175248
22MAP3K131.30522101
23TTN1.29975733
24IRAK41.27959475
25ARAF1.26444840
26RIPK41.24392384
27BUB11.23945774
28BRD41.23068984
29TESK21.22063852
30MAP3K81.20142787
31CDK41.14629269
32CDK71.14037192
33LATS11.14010525
34PAK41.13768716
35TTK1.10801132
36NTRK11.04140302
37TAOK11.02378883
38ERN11.01831718
39RPS6KB21.00435315
40SIK10.98680243
41MAP3K120.96419175
42MATK0.94810851
43MAP3K10.93446710
44AURKA0.90532406
45TBK10.89359743
46ILK0.89062706
47MAP3K90.85226702
48KDR0.80769461
49MTOR0.80493237
50NEK90.80229459
51CHEK20.80223311
52RPS6KA40.79404865
53BRAF0.78627687
54PDGFRA0.78337043
55FES0.77558668
56CSK0.76870951
57PBK0.75871127
58MAP4K10.75618915
59JAK30.75055457
60CDK60.74586909
61RIPK10.73951742
62PIM20.73802262
63MAP2K40.71654834
64PTK60.71124262
65NEK20.71057982
66STK100.70631334
67EIF2AK30.70294631
68CHEK10.66370058
69BMX0.64707354
70VRK20.64076802
71MAP3K50.61797890
72KSR20.61757512
73FGFR40.60524140
74NEK10.60403495
75CDK90.59852643
76PLK40.56523222
77AURKB0.55047673
78AKT20.54345476
79PAK20.53507078
80FGR0.52274081
81ATR0.51044925
82CLK10.50385788
83RET0.49477838
84STK40.49472350
85IRAK20.47039374
86MAP2K20.46231878
87STK240.45787986
88CSF1R0.44988282
89VRK10.44315793
90BLK0.42910576
91MAP2K70.41341886
92LRRK20.41248506
93CDK20.40736309
94PIM10.40278559
95MAP3K30.39551465
96CDK10.39079112
97EPHB10.38886496
98PDPK10.37646267
99PASK0.37581350
100KSR10.37450901

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.42198499
2DNA replication_Homo sapiens_hsa030302.25351313
3Spliceosome_Homo sapiens_hsa030402.25300712
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93302476
5Pentose phosphate pathway_Homo sapiens_hsa000301.75928182
6Acute myeloid leukemia_Homo sapiens_hsa052211.73148402
7B cell receptor signaling pathway_Homo sapiens_hsa046621.72722182
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72075652
9Chronic myeloid leukemia_Homo sapiens_hsa052201.60133105
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54063217
11Viral carcinogenesis_Homo sapiens_hsa052031.50410403
12Systemic lupus erythematosus_Homo sapiens_hsa053221.49432799
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.49389741
14Thyroid cancer_Homo sapiens_hsa052161.48635945
15mRNA surveillance pathway_Homo sapiens_hsa030151.46534246
16Mismatch repair_Homo sapiens_hsa034301.44691736
17Apoptosis_Homo sapiens_hsa042101.44372244
18Pancreatic cancer_Homo sapiens_hsa052121.41983543
19Cell cycle_Homo sapiens_hsa041101.41600122
20RNA transport_Homo sapiens_hsa030131.41041590
21Bladder cancer_Homo sapiens_hsa052191.38247096
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37012701
23Prion diseases_Homo sapiens_hsa050201.34370043
24Shigellosis_Homo sapiens_hsa051311.33826368
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33524885
26Leishmaniasis_Homo sapiens_hsa051401.32352059
27Epstein-Barr virus infection_Homo sapiens_hsa051691.31031601
28Herpes simplex infection_Homo sapiens_hsa051681.29960487
29Renal cell carcinoma_Homo sapiens_hsa052111.27842656
30Hepatitis B_Homo sapiens_hsa051611.26523363
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.23376417
32Osteoclast differentiation_Homo sapiens_hsa043801.21225029
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20901182
34Non-small cell lung cancer_Homo sapiens_hsa052231.18425364
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16790163
36Other glycan degradation_Homo sapiens_hsa005111.15464524
37Legionellosis_Homo sapiens_hsa051341.14140359
38Salmonella infection_Homo sapiens_hsa051321.13678983
39Influenza A_Homo sapiens_hsa051641.08796406
40Biosynthesis of amino acids_Homo sapiens_hsa012301.08237413
41TNF signaling pathway_Homo sapiens_hsa046681.07868593
42Fructose and mannose metabolism_Homo sapiens_hsa000511.06487792
43Base excision repair_Homo sapiens_hsa034101.06234289
44Measles_Homo sapiens_hsa051621.03671147
45HTLV-I infection_Homo sapiens_hsa051661.02284996
46Viral myocarditis_Homo sapiens_hsa054161.01529343
47Toxoplasmosis_Homo sapiens_hsa051451.00260929
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00005414
49Endometrial cancer_Homo sapiens_hsa052130.99907928
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.97984917
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96802442
52Nucleotide excision repair_Homo sapiens_hsa034200.96301109
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95564517
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95483078
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94959096
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94786533
57Antigen processing and presentation_Homo sapiens_hsa046120.93614270
58HIF-1 signaling pathway_Homo sapiens_hsa040660.92547053
59VEGF signaling pathway_Homo sapiens_hsa043700.91589560
60Alcoholism_Homo sapiens_hsa050340.90897795
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88452871
62Tuberculosis_Homo sapiens_hsa051520.88179500
63Prolactin signaling pathway_Homo sapiens_hsa049170.87071864
64Small cell lung cancer_Homo sapiens_hsa052220.86838876
65Colorectal cancer_Homo sapiens_hsa052100.83549414
66Carbon metabolism_Homo sapiens_hsa012000.82696754
67Insulin signaling pathway_Homo sapiens_hsa049100.82406012
68* Ribosome_Homo sapiens_hsa030100.81189990
69Galactose metabolism_Homo sapiens_hsa000520.80383492
70Pyrimidine metabolism_Homo sapiens_hsa002400.79960540
71T cell receptor signaling pathway_Homo sapiens_hsa046600.76977539
72MicroRNAs in cancer_Homo sapiens_hsa052060.75361042
73Notch signaling pathway_Homo sapiens_hsa043300.74491578
74mTOR signaling pathway_Homo sapiens_hsa041500.73443337
75Adherens junction_Homo sapiens_hsa045200.73033314
76ErbB signaling pathway_Homo sapiens_hsa040120.72794382
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72415277
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71866666
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70620382
80Prostate cancer_Homo sapiens_hsa052150.68663945
81Lysosome_Homo sapiens_hsa041420.67184825
82Hepatitis C_Homo sapiens_hsa051600.66988924
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66833125
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.66264667
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64643835
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64500973
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62097111
88Malaria_Homo sapiens_hsa051440.61836049
89Non-homologous end-joining_Homo sapiens_hsa034500.61587128
90Allograft rejection_Homo sapiens_hsa053300.59804168
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.58877157
92Proteoglycans in cancer_Homo sapiens_hsa052050.56718938
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55720471
94Platelet activation_Homo sapiens_hsa046110.55128582
95Focal adhesion_Homo sapiens_hsa045100.52283455
96Amoebiasis_Homo sapiens_hsa051460.51483362
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51461164
98Chemokine signaling pathway_Homo sapiens_hsa040620.49893602
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.49540237
100Pertussis_Homo sapiens_hsa051330.48782772

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