ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.07755462
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.97501758
3	ATP synthesis coupled proton transport (GO:0015986)	5.97501758
4	chaperone-mediated protein transport (GO:0072321)	5.62983925
5	viral transcription (GO:0019083)	5.62387188
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.60359998
7	translational termination (GO:0006415)	5.46141880
8	ribosomal small subunit biogenesis (GO:0042274)	5.37915304
9	maturation of SSU-rRNA (GO:0030490)	5.30667891
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.90323568
11	translational elongation (GO:0006414)	4.78426500
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.75011980
13	cotranslational protein targeting to membrane (GO:0006613)	4.71047580
14	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.69569101
15	protein targeting to ER (GO:0045047)	4.67073451
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.63565040
17	respiratory electron transport chain (GO:0022904)	4.56663215
18	electron transport chain (GO:0022900)	4.51127532
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.50586146
20	DNA deamination (GO:0045006)	4.48705524
21	protein localization to endoplasmic reticulum (GO:0070972)	4.36946015
22	protein complex biogenesis (GO:0070271)	4.36508227
23	viral life cycle (GO:0019058)	4.22027694
24	water-soluble vitamin biosynthetic process (GO:0042364)	4.19112219
25	cellular protein complex disassembly (GO:0043624)	4.11524341
26	behavioral response to nicotine (GO:0035095)	4.06177391
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05903351
28	NADH dehydrogenase complex assembly (GO:0010257)	4.03721476
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.03721476
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.03721476
31	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.02470655
32	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.01598457
33	positive regulation of prostaglandin secretion (GO:0032308)	3.96659220
34	ribosomal large subunit biogenesis (GO:0042273)	3.95841758
35	pyrimidine nucleotide catabolic process (GO:0006244)	3.89103809
36	translational initiation (GO:0006413)	3.87922789
37	translation (GO:0006412)	3.82105716
38	pseudouridine synthesis (GO:0001522)	3.71724422
39	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.70870649
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.69576879
41	ATP biosynthetic process (GO:0006754)	3.65211776
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.57463086
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.55073150
44	peptidyl-histidine modification (GO:0018202)	3.48562047
45	protein-cofactor linkage (GO:0018065)	3.46894782
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.46225256
47	ubiquinone metabolic process (GO:0006743)	3.43243563
48	protein complex disassembly (GO:0043241)	3.38815266
49	base-excision repair, AP site formation (GO:0006285)	3.35409001
50	macromolecular complex disassembly (GO:0032984)	3.31307048
51	cellular component biogenesis (GO:0044085)	3.31073390
52	hydrogen ion transmembrane transport (GO:1902600)	3.30376852
53	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.30327893
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.30185742
55	termination of RNA polymerase III transcription (GO:0006386)	3.30185742
56	protein neddylation (GO:0045116)	3.28142742
57	ncRNA 3-end processing (GO:0043628)	3.26562776
58	positive regulation of fatty acid transport (GO:2000193)	3.25724579
59	GTP biosynthetic process (GO:0006183)	3.22967502
60	ribonucleoprotein complex biogenesis (GO:0022613)	3.15319441
61	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.14973165
62	establishment of protein localization to mitochondrion (GO:0072655)	3.14456582
63	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.14119108
64	protein targeting to mitochondrion (GO:0006626)	3.11975912
65	negative regulation of telomere maintenance (GO:0032205)	3.10893447
66	chromatin remodeling at centromere (GO:0031055)	3.08037309
67	proton transport (GO:0015992)	3.07512290
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.07393076
69	positive regulation of icosanoid secretion (GO:0032305)	3.05887831
70	regulation of memory T cell differentiation (GO:0043380)	3.02646101
71	regulation of prostaglandin secretion (GO:0032306)	3.02374922
72	mRNA catabolic process (GO:0006402)	2.99919588
73	hydrogen transport (GO:0006818)	2.99863134
74	deoxyribonucleotide catabolic process (GO:0009264)	2.96729075
75	protein targeting to membrane (GO:0006612)	2.96057079
76	rRNA processing (GO:0006364)	2.94374898
77	rRNA metabolic process (GO:0016072)	2.91292876
78	otic vesicle formation (GO:0030916)	2.90930221
79	positive regulation of cell fate commitment (GO:0010455)	2.88842205
80	CENP-A containing nucleosome assembly (GO:0034080)	2.85917265
81	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.85168928
82	protein polyglutamylation (GO:0018095)	2.84985033
83	respiratory chain complex IV assembly (GO:0008535)	2.83149723
84	spliceosomal snRNP assembly (GO:0000387)	2.81517078
85	spliceosomal complex assembly (GO:0000245)	2.80460207
86	regulation of mitochondrial translation (GO:0070129)	2.78761749
87	ubiquinone biosynthetic process (GO:0006744)	2.77401571
88	protein localization to mitochondrion (GO:0070585)	2.76474683
89	cytochrome complex assembly (GO:0017004)	2.74211884
90	RNA catabolic process (GO:0006401)	2.72461391
91	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.68902567
92	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.68902567
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.68535771
94	deoxyribose phosphate catabolic process (GO:0046386)	2.67861652
95	UTP biosynthetic process (GO:0006228)	2.66154922
96	piRNA metabolic process (GO:0034587)	2.64476940
97	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63635864
98	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63635864
99	intracellular protein transmembrane import (GO:0044743)	2.63488600
100	UTP metabolic process (GO:0046051)	2.63123490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.32565105
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12942761
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.80428811
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.38544200
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22085387
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.10634318
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.08845304
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.08169509
9	VDR_22108803_ChIP-Seq_LS180_Human	3.06148887
10	EZH2_22144423_ChIP-Seq_EOC_Human	3.01583927
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50337184
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.48247877
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.47417424
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45895967
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.36976472
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.30410166
17	E2F7_22180533_ChIP-Seq_HELA_Human	2.29690796
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.26267672
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.20549632
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20397025
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.20318306
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.19318340
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16476041
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12627996
25	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05510817
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02725315
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94064909
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.88892315
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.79439576
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73820956
31	EWS_26573619_Chip-Seq_HEK293_Human	1.71853967
32	FUS_26573619_Chip-Seq_HEK293_Human	1.66427353
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64647915
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.63963592
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.59681917
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52067608
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.48429852
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47729778
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46031793
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45445269
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44550770
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.42521284
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42240747
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.40138321
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.39976016
46	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.39515042
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39384480
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38911276
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38737336
50	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.37725527
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37579122
52	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.32101081
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31178700
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28012546
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27145385
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22248945
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.22030084
58	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21762274
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21535281
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18400255
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17598843
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.17349856
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17064010
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.16638332
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10142234
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10142234
67	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08229324
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07787916
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05716310
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02753116
71	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02343454
72	AR_20517297_ChIP-Seq_VCAP_Human	1.02155096
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.02067160
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02033570
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01797881
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01345003
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99561627
78	MYC_19829295_ChIP-Seq_ESCs_Human	0.99399234
79	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.99241840
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98844706
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98574914
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94895138
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93581170
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92783283
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91354401
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90933057
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90878147
88	GBX2_23144817_ChIP-Seq_PC3_Human	0.89911403
89	KDM5A_27292631_Chip-Seq_BREAST_Human	0.89043516
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87889580
91	ERA_21632823_ChIP-Seq_H3396_Human	0.85231171
92	GATA3_26560356_Chip-Seq_TH2_Human	0.85072108
93	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84888569
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84888569
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84388248
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.84274464
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84165547
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.83513543
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83351218
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.83168222

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.47999656
2	MP0000566_synostosis	3.88265889
3	MP0006292_abnormal_olfactory_placode	3.49621434
4	MP0003136_yellow_coat_color	2.47275674
5	MP0001188_hyperpigmentation	2.46698284
6	MP0002653_abnormal_ependyma_morphology	2.28140913
7	MP0002277_abnormal_respiratory_mucosa	2.27499614
8	MP0001529_abnormal_vocalization	2.26298432
9	MP0008877_abnormal_DNA_methylation	2.20194213
10	MP0006072_abnormal_retinal_apoptosis	2.19959236
11	MP0003195_calcinosis	2.11252876
12	MP0002837_dystrophic_cardiac_calcinosis	1.92856522
13	MP0005174_abnormal_tail_pigmentation	1.90704123
14	MP0002736_abnormal_nociception_after	1.81500569
15	MP0002095_abnormal_skin_pigmentation	1.79581520
16	MP0001485_abnormal_pinna_reflex	1.78717324
17	MP0001968_abnormal_touch/_nociception	1.74250430
18	MP0003787_abnormal_imprinting	1.73449971
19	MP0000015_abnormal_ear_pigmentation	1.71975762
20	MP0004142_abnormal_muscle_tone	1.67206930
21	MP0008872_abnormal_physiological_respon	1.64180375
22	MP0005075_abnormal_melanosome_morpholog	1.59654346
23	MP0002138_abnormal_hepatobiliary_system	1.58706334
24	MP0001293_anophthalmia	1.56445414
25	MP0008789_abnormal_olfactory_epithelium	1.55472223
26	MP0002938_white_spotting	1.50827923
27	MP0005389_reproductive_system_phenotype	1.48019768
28	MP0001919_abnormal_reproductive_system	1.47727964
29	MP0005646_abnormal_pituitary_gland	1.44587125
30	MP0002638_abnormal_pupillary_reflex	1.43695124
31	MP0000049_abnormal_middle_ear	1.42191744
32	MP0004885_abnormal_endolymph	1.40428215
33	MP0003567_abnormal_fetal_cardiomyocyte	1.37385788
34	MP0005408_hypopigmentation	1.36505449
35	MP0002102_abnormal_ear_morphology	1.35451481
36	MP0003806_abnormal_nucleotide_metabolis	1.28797021
37	MP0008058_abnormal_DNA_repair	1.28787285
38	MP0006276_abnormal_autonomic_nervous	1.28354990
39	MP0004742_abnormal_vestibular_system	1.27751366
40	MP0002160_abnormal_reproductive_system	1.23310717
41	MP0005551_abnormal_eye_electrophysiolog	1.22633637
42	MP0002272_abnormal_nervous_system	1.18788129
43	MP0000631_abnormal_neuroendocrine_gland	1.17386102
44	MP0002876_abnormal_thyroid_physiology	1.15121870
45	MP0003718_maternal_effect	1.14325642
46	MP0001764_abnormal_homeostasis	1.14012450
47	MP0002282_abnormal_trachea_morphology	1.10668364
48	MP0005253_abnormal_eye_physiology	1.10179208
49	MP0000647_abnormal_sebaceous_gland	1.09551099
50	MP0008875_abnormal_xenobiotic_pharmacok	1.09394684
51	MP0003938_abnormal_ear_development	1.08495306
52	MP0001905_abnormal_dopamine_level	1.08457284
53	MP0009745_abnormal_behavioral_response	1.02899870
54	MP0002163_abnormal_gland_morphology	1.00004196
55	MP0004145_abnormal_muscle_electrophysio	0.98476943
56	MP0003646_muscle_fatigue	0.98328853
57	MP0001502_abnormal_circadian_rhythm	0.97782993
58	MP0003011_delayed_dark_adaptation	0.97229899
59	MP0005394_taste/olfaction_phenotype	0.96966492
60	MP0005499_abnormal_olfactory_system	0.96966492
61	MP0005377_hearing/vestibular/ear_phenot	0.96152508
62	MP0003878_abnormal_ear_physiology	0.96152508
63	MP0002234_abnormal_pharynx_morphology	0.93838740
64	MP0005084_abnormal_gallbladder_morpholo	0.93678918
65	MP0003186_abnormal_redox_activity	0.93543698
66	MP0002184_abnormal_innervation	0.92535226
67	MP0009046_muscle_twitch	0.91833176
68	MP0000569_abnormal_digit_pigmentation	0.91759908
69	MP0003693_abnormal_embryo_hatching	0.90340065
70	MP0000383_abnormal_hair_follicle	0.89348971
71	MP0000537_abnormal_urethra_morphology	0.88017980
72	MP0003121_genomic_imprinting	0.85199629
73	MP0004147_increased_porphyrin_level	0.85083104
74	MP0001986_abnormal_taste_sensitivity	0.84897481
75	MP0008995_early_reproductive_senescence	0.84879943
76	MP0005195_abnormal_posterior_eye	0.83908509
77	MP0000465_gastrointestinal_hemorrhage	0.83795942
78	MP0000778_abnormal_nervous_system	0.83548024
79	MP0002210_abnormal_sex_determination	0.82793450
80	MP0005645_abnormal_hypothalamus_physiol	0.82675548
81	MP0002249_abnormal_larynx_morphology	0.81400223
82	MP0000026_abnormal_inner_ear	0.80720864
83	MP0002751_abnormal_autonomic_nervous	0.79755425
84	MP0001963_abnormal_hearing_physiology	0.79536273
85	MP0003890_abnormal_embryonic-extraembry	0.78676887
86	MP0003122_maternal_imprinting	0.76884377
87	MP0009250_abnormal_appendicular_skeleto	0.76512330
88	MP0001984_abnormal_olfaction	0.76274467
89	MP0005187_abnormal_penis_morphology	0.75235928
90	MP0003937_abnormal_limbs/digits/tail_de	0.73127708
91	MP0002752_abnormal_somatic_nervous	0.72839406
92	MP0004957_abnormal_blastocyst_morpholog	0.71098173
93	MP0006035_abnormal_mitochondrial_morpho	0.68765155
94	MP0002557_abnormal_social/conspecific_i	0.67104760
95	MP0001145_abnormal_male_reproductive	0.66360988
96	MP0001970_abnormal_pain_threshold	0.66131385
97	MP0005379_endocrine/exocrine_gland_phen	0.66080829
98	MP0000653_abnormal_sex_gland	0.64986843
99	MP0005636_abnormal_mineral_homeostasis	0.64278495
100	MP0003786_premature_aging	0.63882954

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.96304522
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.67304386
3	Mitochondrial inheritance (HP:0001427)	4.30613229
4	3-Methylglutaconic aciduria (HP:0003535)	4.17029809
5	Acute encephalopathy (HP:0006846)	4.15710694
6	Progressive macrocephaly (HP:0004481)	4.14203795
7	Reticulocytopenia (HP:0001896)	3.95052985
8	Increased CSF lactate (HP:0002490)	3.92013721
9	Increased hepatocellular lipid droplets (HP:0006565)	3.58822894
10	Hepatocellular necrosis (HP:0001404)	3.55504095
11	Lipid accumulation in hepatocytes (HP:0006561)	3.28176125
12	Hepatic necrosis (HP:0002605)	3.25158354
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.15575973
14	Macrocytic anemia (HP:0001972)	3.12301940
15	Renal Fanconi syndrome (HP:0001994)	3.11877007
16	Pancreatic cysts (HP:0001737)	3.11194471
17	True hermaphroditism (HP:0010459)	3.00845568
18	Abnormality of the labia minora (HP:0012880)	2.99166494
19	Cerebral edema (HP:0002181)	2.98792783
20	Rib fusion (HP:0000902)	2.97620657
21	Increased serum lactate (HP:0002151)	2.94759915
22	Increased intramyocellular lipid droplets (HP:0012240)	2.94331953
23	Type II lissencephaly (HP:0007260)	2.93271759
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.78589546
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.78589546
26	Pancreatic fibrosis (HP:0100732)	2.77727007
27	Colon cancer (HP:0003003)	2.76508593
28	Abnormal number of erythroid precursors (HP:0012131)	2.74173130
29	Congenital, generalized hypertrichosis (HP:0004540)	2.65988070
30	Lactic acidosis (HP:0003128)	2.62946777
31	Pendular nystagmus (HP:0012043)	2.61115135
32	Partial duplication of thumb phalanx (HP:0009944)	2.55745879
33	Abnormality of midbrain morphology (HP:0002418)	2.55606623
34	Molar tooth sign on MRI (HP:0002419)	2.55606623
35	Humeroradial synostosis (HP:0003041)	2.54696870
36	Synostosis involving the elbow (HP:0003938)	2.54696870
37	Pallor (HP:0000980)	2.53893317
38	Absent thumb (HP:0009777)	2.44230002
39	Increased muscle lipid content (HP:0009058)	2.39661635
40	Optic disc pallor (HP:0000543)	2.39560701
41	IgG deficiency (HP:0004315)	2.37698845
42	Nephronophthisis (HP:0000090)	2.36570633
43	Hypoplasia of the radius (HP:0002984)	2.35150476
44	Septo-optic dysplasia (HP:0100842)	2.29421411
45	Retinal dysplasia (HP:0007973)	2.24849038
46	Respiratory failure (HP:0002878)	2.22471383
47	Abolished electroretinogram (ERG) (HP:0000550)	2.22227834
48	Partial duplication of the phalanx of hand (HP:0009999)	2.21809930
49	Leukodystrophy (HP:0002415)	2.19015682
50	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.18977649
51	Sclerocornea (HP:0000647)	2.15672163
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14545947
53	Stenosis of the external auditory canal (HP:0000402)	2.11303034
54	Hypoplasia of the ulna (HP:0003022)	2.09843093
55	Abnormality of the middle phalanges of the toes (HP:0010183)	2.06216539
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06190202
57	Abnormality of alanine metabolism (HP:0010916)	2.06190202
58	Hyperalaninemia (HP:0003348)	2.06190202
59	Lethargy (HP:0001254)	2.05183412
60	Congenital stationary night blindness (HP:0007642)	2.04951611
61	Pancytopenia (HP:0001876)	2.04779106
62	Exertional dyspnea (HP:0002875)	2.03772655
63	Renal cortical cysts (HP:0000803)	2.00834189
64	Forearm undergrowth (HP:0009821)	2.00822893
65	Hyperglycinemia (HP:0002154)	2.00055101
66	Exercise intolerance (HP:0003546)	1.99291438
67	Cleft eyelid (HP:0000625)	1.98248350
68	Male pseudohermaphroditism (HP:0000037)	1.96420990
69	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91731029
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90773789
71	Abnormality of renal resorption (HP:0011038)	1.88774192
72	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.87883897
73	Hyperphosphaturia (HP:0003109)	1.85366347
74	Abnormality of the renal medulla (HP:0100957)	1.84621100
75	Progressive microcephaly (HP:0000253)	1.84441719
76	Oligodactyly (hands) (HP:0001180)	1.83240755
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.82275388
78	B lymphocytopenia (HP:0010976)	1.81795358
79	Methylmalonic acidemia (HP:0002912)	1.81784414
80	Methylmalonic aciduria (HP:0012120)	1.81345644
81	Triphalangeal thumb (HP:0001199)	1.79332484
82	Esophageal atresia (HP:0002032)	1.78150103
83	Maternal diabetes (HP:0009800)	1.76872939
84	Chronic hepatic failure (HP:0100626)	1.75988249
85	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.75208101
86	Abnormality of the renal cortex (HP:0011035)	1.75076380
87	Bilateral microphthalmos (HP:0007633)	1.74167419
88	Poor head control (HP:0002421)	1.73118635
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.71829598
90	Anencephaly (HP:0002323)	1.69205978
91	CNS demyelination (HP:0007305)	1.69156572
92	Oligodactyly (HP:0012165)	1.68709850
93	Meckel diverticulum (HP:0002245)	1.68369872
94	Holoprosencephaly (HP:0001360)	1.66994097
95	Cystic liver disease (HP:0006706)	1.66901212
96	Optic nerve hypoplasia (HP:0000609)	1.66666279
97	Blindness (HP:0000618)	1.65173155
98	Medial flaring of the eyebrow (HP:0010747)	1.65038857
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.64611081
100	Abnormality of methionine metabolism (HP:0010901)	1.64384390

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.01516034
2	PINK1	3.42709365
3	WNK4	3.20716596
4	ZAK	3.05357249
5	NME1	2.78166797
6	DYRK2	2.67797149
7	MAP4K2	2.39948603
8	STK39	2.26098462
9	NUAK1	2.24888823
10	BCKDK	2.21708262
11	CDC7	2.21424271
12	VRK1	2.05979588
13	TLK1	1.85934770
14	GRK1	1.76082724
15	CDK19	1.70219417
16	ADRBK2	1.62594057
17	TXK	1.59828218
18	CSNK1G3	1.56906866
19	STK16	1.52529824
20	CSNK1G1	1.40210316
21	CAMKK2	1.37870665
22	CSNK1G2	1.35699183
23	NME2	1.34261646
24	TAOK3	1.33847182
25	FGFR2	1.33472362
26	PDK2	1.30886922
27	TAF1	1.30156656
28	SRPK1	1.25737737
29	CSNK1A1L	1.24577599
30	BUB1	1.24438716
31	TEC	1.20682900
32	PAK3	1.19049030
33	BMPR1B	1.12884036
34	MAP2K7	1.11214087
35	FRK	1.04327591
36	WEE1	0.99504405
37	MAP3K4	0.97408168
38	MATK	0.95670005
39	PRKCG	0.92168105
40	WNK3	0.92052892
41	TIE1	0.90198581
42	PHKG1	0.86764320
43	PHKG2	0.86764320
44	PRKCQ	0.86201396
45	ATR	0.82264779
46	EIF2AK2	0.80085951
47	RPS6KA5	0.78894299
48	PRKCI	0.77844395
49	KIT	0.77590850
50	WNK1	0.77023446
51	EPHA3	0.72612746
52	PNCK	0.72266579
53	AURKB	0.71228112
54	IKBKB	0.70487123
55	CASK	0.69261774
56	TRIM28	0.68372436
57	AURKA	0.67888038
58	IKBKE	0.67672013
59	PLK3	0.67275602
60	KDR	0.66049824
61	CSNK2A2	0.64720862
62	SYK	0.62858098
63	OXSR1	0.61608437
64	CSNK1A1	0.59679354
65	INSRR	0.59665286
66	MINK1	0.59159459
67	ARAF	0.57666159
68	PIM1	0.57474200
69	PLK1	0.54648579
70	CAMK1	0.54415100
71	MAP2K2	0.54211709
72	LRRK2	0.53832565
73	ADRBK1	0.52679758
74	CSNK1E	0.52678426
75	NEK1	0.52055078
76	BCR	0.49460801
77	PRKACA	0.47983953
78	OBSCN	0.46973379
79	PRKCE	0.46031147
80	ITK	0.45147318
81	PIK3CA	0.44602107
82	PLK4	0.44343546
83	PRKCH	0.44028679
84	CSNK2A1	0.42523221
85	GRK6	0.42071063
86	MST4	0.41354976
87	MAP2K6	0.39027158
88	ERBB2	0.37877140
89	BTK	0.37813230
90	EIF2AK1	0.37746755
91	MAPK13	0.36644726
92	MUSK	0.36431151
93	MAP3K11	0.34612659
94	GRK5	0.33396920
95	MAP3K9	0.33203134
96	PRKCD	0.32983675
97	PRKCA	0.31816606
98	CHEK2	0.28846954
99	TNIK	0.24509561
100	CHEK1	0.24157080

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.04562745
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.33661031
3	Parkinsons disease_Homo sapiens_hsa05012	3.67631118
4	Proteasome_Homo sapiens_hsa03050	3.09787721
5	RNA polymerase_Homo sapiens_hsa03020	2.94107494
6	Huntingtons disease_Homo sapiens_hsa05016	2.53091723
7	Alzheimers disease_Homo sapiens_hsa05010	2.42269723
8	Protein export_Homo sapiens_hsa03060	2.39381875
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16294186
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.15817088
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15270881
12	Homologous recombination_Homo sapiens_hsa03440	2.13866310
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.09128962
14	Mismatch repair_Homo sapiens_hsa03430	2.08151295
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.00316556
16	DNA replication_Homo sapiens_hsa03030	1.90314743
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.88933999
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74329810
19	Sulfur metabolism_Homo sapiens_hsa00920	1.66664975
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.59876109
21	Basal transcription factors_Homo sapiens_hsa03022	1.53415264
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52330966
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.52268305
24	RNA degradation_Homo sapiens_hsa03018	1.50939560
25	One carbon pool by folate_Homo sapiens_hsa00670	1.44585763
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42026333
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.35124629
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.31536333
29	Spliceosome_Homo sapiens_hsa03040	1.29540261
30	Butanoate metabolism_Homo sapiens_hsa00650	1.27253552
31	Base excision repair_Homo sapiens_hsa03410	1.26894229
32	Purine metabolism_Homo sapiens_hsa00230	1.21169461
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19707844
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12952073
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08850510
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08429189
37	RNA transport_Homo sapiens_hsa03013	1.04167638
38	Caffeine metabolism_Homo sapiens_hsa00232	1.02562533
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.01746053
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00538404
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96929203
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.96650919
43	Peroxisome_Homo sapiens_hsa04146	0.96065195
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93096625
45	Asthma_Homo sapiens_hsa05310	0.89082877
46	Folate biosynthesis_Homo sapiens_hsa00790	0.88942843
47	Phototransduction_Homo sapiens_hsa04744	0.88930610
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88525786
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87956698
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.81684642
51	Propanoate metabolism_Homo sapiens_hsa00640	0.80942884
52	Metabolic pathways_Homo sapiens_hsa01100	0.77981549
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77130974
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76995572
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76901137
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.75554675
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.74732989
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.72960850
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62558947
60	Nicotine addiction_Homo sapiens_hsa05033	0.60544005
61	Olfactory transduction_Homo sapiens_hsa04740	0.60431956
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60261737
63	Taste transduction_Homo sapiens_hsa04742	0.59865250
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57203240
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57020768
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56746437
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56106039
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55528423
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55014440
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53510239
71	Sulfur relay system_Homo sapiens_hsa04122	0.52282863
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.50961749
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50536630
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.50484739
75	Allograft rejection_Homo sapiens_hsa05330	0.50162714
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48456826
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48409205
78	Glutathione metabolism_Homo sapiens_hsa00480	0.48360472
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48040580
80	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48002705
81	Retinol metabolism_Homo sapiens_hsa00830	0.43895337
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43638037
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42492933
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41999510
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41147086
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.39605263
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39221153
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38250944
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34954487
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.34038869
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33642783
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.33239637
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.32720186
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30735895
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28786122
96	Serotonergic synapse_Homo sapiens_hsa04726	0.28445231
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28355240
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.25450861
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.23202620
100	Morphine addiction_Homo sapiens_hsa05032	0.21862687

RPS10P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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