ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.44011611
2	translational termination (GO:0006415)	6.22397805
3	ribosomal small subunit assembly (GO:0000028)	6.16580588
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.47600604
5	ATP synthesis coupled proton transport (GO:0015986)	5.47600604
6	maturation of SSU-rRNA (GO:0030490)	5.41479220
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.40624801
8	behavioral response to nicotine (GO:0035095)	5.37215463
9	ribosomal small subunit biogenesis (GO:0042274)	5.35067427
10	cotranslational protein targeting to membrane (GO:0006613)	5.32322315
11	protein targeting to ER (GO:0045047)	5.28820537
12	translational elongation (GO:0006414)	5.19539923
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.12362202
14	protein localization to endoplasmic reticulum (GO:0070972)	5.01010099
15	protein neddylation (GO:0045116)	5.00776584
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.82764844
17	viral life cycle (GO:0019058)	4.77997451
18	chaperone-mediated protein transport (GO:0072321)	4.75965526
19	cellular protein complex disassembly (GO:0043624)	4.65432831
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58836876
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.49319592
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.49319592
23	NADH dehydrogenase complex assembly (GO:0010257)	4.49319592
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.48705887
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.31144331
26	protein complex biogenesis (GO:0070271)	4.27862009
27	respiratory electron transport chain (GO:0022904)	4.08837699
28	electron transport chain (GO:0022900)	4.07021577
29	translational initiation (GO:0006413)	4.05121844
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.03120272
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.96154279
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.96154279
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.94929543
34	protein-cofactor linkage (GO:0018065)	3.91307507
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.88934426
36	ribosomal large subunit biogenesis (GO:0042273)	3.88687704
37	protein complex disassembly (GO:0043241)	3.87950945
38	macromolecular complex disassembly (GO:0032984)	3.80219118
39	GTP biosynthetic process (GO:0006183)	3.65511834
40	translation (GO:0006412)	3.61612781
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.58568674
42	termination of RNA polymerase III transcription (GO:0006386)	3.58568674
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48471567
44	protein targeting to membrane (GO:0006612)	3.45941517
45	substrate-independent telencephalic tangential migration (GO:0021826)	3.32441149
46	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.32441149
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.27146753
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.27129886
49	mRNA catabolic process (GO:0006402)	3.26878571
50	water-soluble vitamin biosynthetic process (GO:0042364)	3.25394107
51	hydrogen ion transmembrane transport (GO:1902600)	3.22019778
52	DNA deamination (GO:0045006)	3.15443344
53	ATP biosynthetic process (GO:0006754)	3.15009271
54	cellular component biogenesis (GO:0044085)	3.13220885
55	UTP biosynthetic process (GO:0006228)	3.07038623
56	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.06706682
57	RNA catabolic process (GO:0006401)	2.98183426
58	proton transport (GO:0015992)	2.97402810
59	respiratory chain complex IV assembly (GO:0008535)	2.95899912
60	cell proliferation in forebrain (GO:0021846)	2.94233715
61	axon ensheathment in central nervous system (GO:0032291)	2.94198160
62	central nervous system myelination (GO:0022010)	2.94198160
63	regulation of cellular respiration (GO:0043457)	2.93960477
64	cellular biogenic amine catabolic process (GO:0042402)	2.93707276
65	amine catabolic process (GO:0009310)	2.93707276
66	kynurenine metabolic process (GO:0070189)	2.93163973
67	hydrogen transport (GO:0006818)	2.93141514
68	ribonucleoprotein complex biogenesis (GO:0022613)	2.92679862
69	UTP metabolic process (GO:0046051)	2.92458664
70	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.89657407
71	indole-containing compound catabolic process (GO:0042436)	2.89595781
72	indolalkylamine catabolic process (GO:0046218)	2.89595781
73	tryptophan catabolic process (GO:0006569)	2.89595781
74	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.89486226
75	positive regulation of protein homooligomerization (GO:0032464)	2.89292507
76	resolution of meiotic recombination intermediates (GO:0000712)	2.85984407
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84273383
78	ribonucleoprotein complex disassembly (GO:0032988)	2.78932187
79	hypothalamus development (GO:0021854)	2.76080303
80	platelet dense granule organization (GO:0060155)	2.74379390
81	intracellular protein transmembrane import (GO:0044743)	2.73250111
82	CTP metabolic process (GO:0046036)	2.72677429
83	CTP biosynthetic process (GO:0006241)	2.72677429
84	regulation of cilium movement (GO:0003352)	2.72208928
85	protein polyglutamylation (GO:0018095)	2.70543660
86	GPI anchor metabolic process (GO:0006505)	2.68361094
87	organelle disassembly (GO:1903008)	2.67265083
88	mannosylation (GO:0097502)	2.66346671
89	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.65003775
90	tRNA processing (GO:0008033)	2.64620741
91	parturition (GO:0007567)	2.63834428
92	indolalkylamine metabolic process (GO:0006586)	2.63021118
93	rRNA catabolic process (GO:0016075)	2.61758806
94	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.61511183
95	positive regulation of prostaglandin secretion (GO:0032308)	2.56936741
96	intraciliary transport (GO:0042073)	2.56708383
97	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.55319059
98	nucleoside triphosphate biosynthetic process (GO:0009142)	2.52851463
99	cardiovascular system development (GO:0072358)	2.52405698
100	protein targeting to mitochondrion (GO:0006626)	2.52228361

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.74347711
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.03548274
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.71059594
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65039158
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22109548
6	VDR_22108803_ChIP-Seq_LS180_Human	2.89200346
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88076132
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.72698703
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67906641
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.64751498
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50199610
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.39727636
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35964493
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.34913718
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15405099
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.09206635
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.87442901
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.86365652
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83762763
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.73382336
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64152328
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61844121
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61496778
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61266731
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55565294
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52954147
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50937751
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.50750258
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47999501
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.47512764
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45528750
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42351620
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41877432
34	EWS_26573619_Chip-Seq_HEK293_Human	1.37551506
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36605270
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.36010451
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33950748
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31970168
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31335865
40	FUS_26573619_Chip-Seq_HEK293_Human	1.31000030
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.28619363
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28491025
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27551661
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25056881
45	NCOR_22424771_ChIP-Seq_293T_Human	1.24245458
46	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23756540
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21439171
48	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18560379
49	XRN2_22483619_ChIP-Seq_HELA_Human	1.17874609
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15693924
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15471103
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15309940
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15247106
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13308065
55	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13189669
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12966264
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11236444
58	AR_20517297_ChIP-Seq_VCAP_Human	1.08611188
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07924943
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07478619
61	ERA_21632823_ChIP-Seq_H3396_Human	1.06868000
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04975252
63	MYC_19829295_ChIP-Seq_ESCs_Human	1.04346052
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02234317
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02132162
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02132162
67	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02113744
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02019665
69	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.01341848
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01324034
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01324034
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01300194
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00614291
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00594504
75	P300_19829295_ChIP-Seq_ESCs_Human	0.99421254
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99316802
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98822052
78	ER_23166858_ChIP-Seq_MCF-7_Human	0.98405467
79	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97337304
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96582471
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96057440
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95979435
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95869964
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93502534
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92623059
86	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91173981
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.90984029
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90984029
89	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.90704681
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90499911
91	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.90456743
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90408241
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86627185
94	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86197708
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85973310
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.85892519
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85644833
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.82445505
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.81852573
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.81852445

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.30623951
2	MP0006292_abnormal_olfactory_placode	4.30138078
3	MP0003787_abnormal_imprinting	3.42142627
4	MP0008877_abnormal_DNA_methylation	2.88133012
5	MP0003122_maternal_imprinting	2.74867459
6	MP0004142_abnormal_muscle_tone	2.44031566
7	MP0006072_abnormal_retinal_apoptosis	2.21325907
8	MP0002138_abnormal_hepatobiliary_system	2.15434092
9	MP0001986_abnormal_taste_sensitivity	2.14167863
10	MP0003121_genomic_imprinting	2.04013132
11	MP0002837_dystrophic_cardiac_calcinosis	2.02193592
12	MP0001968_abnormal_touch/_nociception	2.00917188
13	MP0003123_paternal_imprinting	1.96869242
14	MP0008789_abnormal_olfactory_epithelium	1.94627163
15	MP0005646_abnormal_pituitary_gland	1.92333805
16	MP0003646_muscle_fatigue	1.90316396
17	MP0004147_increased_porphyrin_level	1.89086249
18	MP0002653_abnormal_ependyma_morphology	1.87654460
19	MP0002736_abnormal_nociception_after	1.86911232
20	MP0003011_delayed_dark_adaptation	1.85771386
21	MP0002876_abnormal_thyroid_physiology	1.81107077
22	MP0003806_abnormal_nucleotide_metabolis	1.78025174
23	MP0005551_abnormal_eye_electrophysiolog	1.75715882
24	MP0005423_abnormal_somatic_nervous	1.72388880
25	MP0004145_abnormal_muscle_electrophysio	1.70808798
26	MP0001835_abnormal_antigen_presentation	1.68058875
27	MP0006276_abnormal_autonomic_nervous	1.67672658
28	MP0003880_abnormal_central_pattern	1.66198956
29	MP0002102_abnormal_ear_morphology	1.63476153
30	MP0002163_abnormal_gland_morphology	1.61792915
31	MP0002938_white_spotting	1.61740103
32	MP0002272_abnormal_nervous_system	1.58506936
33	MP0009745_abnormal_behavioral_response	1.53569603
34	MP0009046_muscle_twitch	1.51832285
35	MP0001905_abnormal_dopamine_level	1.48334723
36	MP0005377_hearing/vestibular/ear_phenot	1.45301498
37	MP0003878_abnormal_ear_physiology	1.45301498
38	MP0000778_abnormal_nervous_system	1.41998708
39	MP0005394_taste/olfaction_phenotype	1.41640217
40	MP0005499_abnormal_olfactory_system	1.41640217
41	MP0008872_abnormal_physiological_respon	1.40415026
42	MP0002638_abnormal_pupillary_reflex	1.39223034
43	MP0001293_anophthalmia	1.37914073
44	MP0005671_abnormal_response_to	1.37003076
45	MP0008875_abnormal_xenobiotic_pharmacok	1.36314611
46	MP0001529_abnormal_vocalization	1.34555967
47	MP0000631_abnormal_neuroendocrine_gland	1.32755603
48	MP0005253_abnormal_eye_physiology	1.28717792
49	MP0001485_abnormal_pinna_reflex	1.24555152
50	MP0003186_abnormal_redox_activity	1.24102235
51	MP0001970_abnormal_pain_threshold	1.21338263
52	MP0005075_abnormal_melanosome_morpholog	1.21316253
53	MP0001440_abnormal_grooming_behavior	1.13832049
54	MP0003136_yellow_coat_color	1.13415967
55	MP0005195_abnormal_posterior_eye	1.13173718
56	MP0002733_abnormal_thermal_nociception	1.12523962
57	MP0004885_abnormal_endolymph	1.11003028
58	MP0000372_irregular_coat_pigmentation	1.10257703
59	MP0001984_abnormal_olfaction	1.10157791
60	MP0005670_abnormal_white_adipose	1.04014567
61	MP0002752_abnormal_somatic_nervous	1.02268403
62	MP0005084_abnormal_gallbladder_morpholo	1.00977593
63	MP0002184_abnormal_innervation	1.00595670
64	MP0002557_abnormal_social/conspecific_i	1.00501842
65	MP0009764_decreased_sensitivity_to	1.00207557
66	MP0004133_heterotaxia	1.00184038
67	MP0001486_abnormal_startle_reflex	0.98577655
68	MP0000049_abnormal_middle_ear	0.98481955
69	MP0000569_abnormal_digit_pigmentation	0.98140940
70	MP0002095_abnormal_skin_pigmentation	0.95698668
71	MP0002572_abnormal_emotion/affect_behav	0.95655196
72	MP0005389_reproductive_system_phenotype	0.95523891
73	MP0000955_abnormal_spinal_cord	0.94603948
74	MP0002160_abnormal_reproductive_system	0.90232460
75	MP0000026_abnormal_inner_ear	0.89717670
76	MP0001963_abnormal_hearing_physiology	0.87484255
77	MP0005379_endocrine/exocrine_gland_phen	0.87463377
78	MP0001764_abnormal_homeostasis	0.87029395
79	MP0005408_hypopigmentation	0.86970235
80	MP0006036_abnormal_mitochondrial_physio	0.86544274
81	MP0002064_seizures	0.86536853
82	MP0001919_abnormal_reproductive_system	0.84870438
83	MP0008058_abnormal_DNA_repair	0.84843107
84	MP0002210_abnormal_sex_determination	0.83595487
85	MP0002067_abnormal_sensory_capabilities	0.82836351
86	MP0001188_hyperpigmentation	0.81693003
87	MP0002735_abnormal_chemical_nociception	0.80608467
88	MP0002063_abnormal_learning/memory/cond	0.79997888
89	MP0010386_abnormal_urinary_bladder	0.79656037
90	MP0004742_abnormal_vestibular_system	0.76707394
91	MP0008995_early_reproductive_senescence	0.75770543
92	MP0003879_abnormal_hair_cell	0.75551492
93	MP0005391_vision/eye_phenotype	0.75134963
94	MP0003693_abnormal_embryo_hatching	0.75040206
95	MP0003635_abnormal_synaptic_transmissio	0.74231699
96	MP0002277_abnormal_respiratory_mucosa	0.73413025
97	MP0001324_abnormal_eye_pigmentation	0.73238120
98	MP0003195_calcinosis	0.72208769
99	MP0002734_abnormal_mechanical_nocicepti	0.72066198
100	MP0003786_premature_aging	0.71688566

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.58183485
2	Reticulocytopenia (HP:0001896)	4.26355021
3	Mitochondrial inheritance (HP:0001427)	4.11529132
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.05144328
5	Acute encephalopathy (HP:0006846)	4.03406833
6	3-Methylglutaconic aciduria (HP:0003535)	3.89064864
7	Pancreatic cysts (HP:0001737)	3.78286841
8	Increased CSF lactate (HP:0002490)	3.72063306
9	Progressive macrocephaly (HP:0004481)	3.64605947
10	Pancreatic fibrosis (HP:0100732)	3.63855178
11	Abnormality of midbrain morphology (HP:0002418)	3.62206061
12	Molar tooth sign on MRI (HP:0002419)	3.62206061
13	Hepatocellular necrosis (HP:0001404)	3.56232282
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.51067713
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.32115068
16	Macrocytic anemia (HP:0001972)	3.26306936
17	Nephronophthisis (HP:0000090)	3.21654933
18	Hepatic necrosis (HP:0002605)	3.14037954
19	Congenital, generalized hypertrichosis (HP:0004540)	3.08928690
20	True hermaphroditism (HP:0010459)	3.08184146
21	Increased hepatocellular lipid droplets (HP:0006565)	3.02401837
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.00424028
23	Pendular nystagmus (HP:0012043)	2.97830900
24	Congenital stationary night blindness (HP:0007642)	2.95181649
25	Lipid accumulation in hepatocytes (HP:0006561)	2.91488244
26	Cerebral edema (HP:0002181)	2.81640333
27	Adrenal hypoplasia (HP:0000835)	2.75997110
28	Abnormality of the renal medulla (HP:0100957)	2.59562663
29	Renal Fanconi syndrome (HP:0001994)	2.57565816
30	Optic disc pallor (HP:0000543)	2.57556662
31	Myokymia (HP:0002411)	2.52478328
32	Medial flaring of the eyebrow (HP:0010747)	2.51338600
33	Pallor (HP:0000980)	2.48843841
34	Abolished electroretinogram (ERG) (HP:0000550)	2.47891979
35	Sclerocornea (HP:0000647)	2.43123386
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38808665
37	Absent thumb (HP:0009777)	2.37748461
38	Abnormal ciliary motility (HP:0012262)	2.37141010
39	Type 2 muscle fiber atrophy (HP:0003554)	2.35186666
40	Abnormal number of erythroid precursors (HP:0012131)	2.34635460
41	Tubular atrophy (HP:0000092)	2.34388451
42	Cystic liver disease (HP:0006706)	2.33447980
43	Hyperglycinemia (HP:0002154)	2.32654240
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31737890
45	Septo-optic dysplasia (HP:0100842)	2.29751310
46	Asplenia (HP:0001746)	2.29690599
47	Increased serum lactate (HP:0002151)	2.29043998
48	Abnormal biliary tract physiology (HP:0012439)	2.28417124
49	Bile duct proliferation (HP:0001408)	2.28417124
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24865603
51	Absent/shortened dynein arms (HP:0200106)	2.24865603
52	Lactic acidosis (HP:0003128)	2.23289625
53	Rib fusion (HP:0000902)	2.14512164
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.12714232
55	Abnormality of DNA repair (HP:0003254)	2.11896164
56	Abnormality of the prostate (HP:0008775)	2.10878017
57	Exertional dyspnea (HP:0002875)	2.08249327
58	Colon cancer (HP:0003003)	2.07946091
59	Leukodystrophy (HP:0002415)	2.06349655
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.03827450
61	Respiratory failure (HP:0002878)	2.02454290
62	Abnormality of the renal cortex (HP:0011035)	2.02020671
63	Methylmalonic acidemia (HP:0002912)	1.99433595
64	Increased intramyocellular lipid droplets (HP:0012240)	1.97468257
65	Abnormal drinking behavior (HP:0030082)	1.95461388
66	Polydipsia (HP:0001959)	1.95461388
67	Muscle fiber atrophy (HP:0100295)	1.95354715
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94890091
69	Abnormal respiratory epithelium morphology (HP:0012253)	1.94568162
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94568162
71	Male pseudohermaphroditism (HP:0000037)	1.94492418
72	Abnormality of the labia minora (HP:0012880)	1.92370848
73	Anencephaly (HP:0002323)	1.92341740
74	Keratoconus (HP:0000563)	1.91342729
75	Increased corneal curvature (HP:0100692)	1.91342729
76	Severe visual impairment (HP:0001141)	1.88412310
77	Gait imbalance (HP:0002141)	1.87433782
78	Postaxial foot polydactyly (HP:0001830)	1.84682694
79	Constricted visual fields (HP:0001133)	1.83612344
80	Stenosis of the external auditory canal (HP:0000402)	1.82724367
81	Congenital primary aphakia (HP:0007707)	1.82526970
82	Chronic hepatic failure (HP:0100626)	1.82495720
83	Abnormality of urine glucose concentration (HP:0011016)	1.80864204
84	Glycosuria (HP:0003076)	1.80864204
85	Lethargy (HP:0001254)	1.80211820
86	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79345999
87	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79345999
88	Congenital hepatic fibrosis (HP:0002612)	1.78459919
89	Agitation (HP:0000713)	1.77747623
90	Nephrogenic diabetes insipidus (HP:0009806)	1.77081842
91	Type II lissencephaly (HP:0007260)	1.76995276
92	Depressed nasal ridge (HP:0000457)	1.76946698
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74001049
94	Growth hormone deficiency (HP:0000824)	1.73806492
95	Abnormality of renal resorption (HP:0011038)	1.72468281
96	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.72311713
97	Abnormality of alanine metabolism (HP:0010916)	1.72311713
98	Hyperalaninemia (HP:0003348)	1.72311713
99	Optic nerve hypoplasia (HP:0000609)	1.70984764
100	Triphalangeal thumb (HP:0001199)	1.68573418

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.92994979
2	CDK19	3.32801350
3	WNK4	3.01664310
4	TLK1	2.64597931
5	STK16	2.38380754
6	MAP4K2	2.25814363
7	PINK1	2.14804847
8	ADRBK2	2.12471202
9	DYRK2	2.06690341
10	TXK	2.02160598
11	GRK1	1.92974251
12	NUAK1	1.84784504
13	PIK3CA	1.73394932
14	BCKDK	1.72641372
15	TIE1	1.68859942
16	OXSR1	1.67048993
17	FRK	1.62481511
18	STK39	1.60532000
19	TAOK3	1.59539192
20	BMPR1B	1.57716794
21	VRK2	1.57028758
22	TEC	1.52374844
23	WNK3	1.40559234
24	MAP2K7	1.32535374
25	NEK1	1.22765738
26	CDC7	1.21154076
27	MAP3K4	1.19951790
28	KIT	1.15755518
29	ITK	1.13379499
30	RPS6KA4	1.11659642
31	CAMKK2	1.09860357
32	BRAF	1.06348698
33	BTK	1.03817549
34	RPS6KA5	1.03364728
35	NME2	1.01161653
36	VRK1	1.00837109
37	PRKCQ	0.98401789
38	NTRK2	0.97027816
39	CSNK1G3	0.93196614
40	DYRK3	0.92959499
41	PRKCG	0.88235007
42	DYRK1B	0.85162694
43	LIMK1	0.84153061
44	CSNK1G2	0.81909981
45	INSRR	0.80479645
46	CAMK1	0.80174347
47	TRIM28	0.79615881
48	IKBKB	0.79211242
49	CSNK1A1L	0.78447805
50	MAP3K12	0.78447111
51	AURKB	0.78215333
52	PHKG1	0.76625209
53	PHKG2	0.76625209
54	TNK2	0.67810928
55	CASK	0.67171568
56	MKNK2	0.63883688
57	CHEK2	0.63824313
58	NTRK3	0.63817849
59	PAK3	0.63603016
60	TAF1	0.63361513
61	MAPK13	0.62543030
62	MINK1	0.59295472
63	STK11	0.59116862
64	KDR	0.59108782
65	SYK	0.59047468
66	ADRBK1	0.59000403
67	PLK1	0.58159331
68	MAP2K4	0.57028512
69	LYN	0.56680694
70	EIF2AK1	0.55659973
71	LRRK2	0.55650467
72	ATR	0.55419687
73	EPHA4	0.55258151
74	DAPK3	0.54871543
75	CSNK1G1	0.54858905
76	CSNK2A2	0.54510102
77	PRKACA	0.54107172
78	CCNB1	0.52615111
79	AURKA	0.52235190
80	MAP3K11	0.51040872
81	PRKCE	0.50544241
82	CSNK1A1	0.50441866
83	BMPR2	0.50310551
84	TGFBR1	0.47307126
85	NEK2	0.47113215
86	ICK	0.46714385
87	RPS6KA6	0.45992714
88	MKNK1	0.44899969
89	AKT3	0.44884861
90	PRKCD	0.43626878
91	TYRO3	0.43027595
92	MAPKAPK5	0.42998244
93	SGK494	0.42748379
94	SGK223	0.42748379
95	OBSCN	0.42432219
96	ABL2	0.42198729
97	EIF2AK3	0.42194518
98	PASK	0.41453504
99	GRK6	0.41214556
100	NME1	0.40874617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.05839854
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.15412840
3	Parkinsons disease_Homo sapiens_hsa05012	3.49307752
4	Asthma_Homo sapiens_hsa05310	3.30640983
5	Proteasome_Homo sapiens_hsa03050	2.58488899
6	RNA polymerase_Homo sapiens_hsa03020	2.53388187
7	Huntingtons disease_Homo sapiens_hsa05016	2.44548333
8	Allograft rejection_Homo sapiens_hsa05330	2.37470594
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.37155696
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.31779812
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.28237964
12	Alzheimers disease_Homo sapiens_hsa05010	2.25265604
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.14308917
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06403426
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01628834
16	Protein export_Homo sapiens_hsa03060	2.01204999
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98658221
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82819741
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64700060
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63021217
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62865463
22	RNA degradation_Homo sapiens_hsa03018	1.58066493
23	Homologous recombination_Homo sapiens_hsa03440	1.57532994
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48846346
25	Phototransduction_Homo sapiens_hsa04744	1.36510058
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25121068
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23574644
28	Basal transcription factors_Homo sapiens_hsa03022	1.19900912
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.15805887
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14466662
31	Caffeine metabolism_Homo sapiens_hsa00232	1.10532916
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.06464276
33	Nicotine addiction_Homo sapiens_hsa05033	1.02729273
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98001263
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95161290
36	Peroxisome_Homo sapiens_hsa04146	0.94483764
37	Sulfur relay system_Homo sapiens_hsa04122	0.93509726
38	One carbon pool by folate_Homo sapiens_hsa00670	0.93179193
39	Butanoate metabolism_Homo sapiens_hsa00650	0.90307829
40	Antigen processing and presentation_Homo sapiens_hsa04612	0.89643989
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87809540
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.87677025
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87619238
44	Purine metabolism_Homo sapiens_hsa00230	0.87117674
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.86242125
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.85844422
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85753433
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.85746229
49	Regulation of autophagy_Homo sapiens_hsa04140	0.85124233
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84261229
51	Propanoate metabolism_Homo sapiens_hsa00640	0.83420679
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82700462
53	Viral myocarditis_Homo sapiens_hsa05416	0.77973087
54	Base excision repair_Homo sapiens_hsa03410	0.77076988
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75772982
56	Mismatch repair_Homo sapiens_hsa03430	0.73851828
57	DNA replication_Homo sapiens_hsa03030	0.72188077
58	Spliceosome_Homo sapiens_hsa03040	0.71660744
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69789926
60	Olfactory transduction_Homo sapiens_hsa04740	0.69078400
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68877778
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65352358
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.65323267
64	Retinol metabolism_Homo sapiens_hsa00830	0.65213716
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65211920
66	Metabolic pathways_Homo sapiens_hsa01100	0.63663154
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.62098097
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61566360
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61308234
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60953127
71	Morphine addiction_Homo sapiens_hsa05032	0.60666537
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60398156
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.56513452
74	Sulfur metabolism_Homo sapiens_hsa00920	0.55233314
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52699255
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51324392
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49811873
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49503707
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46887581
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46226697
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44376136
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43270304
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39891943
84	GABAergic synapse_Homo sapiens_hsa04727	0.36571410
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.36448884
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35104409
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34731008
88	RNA transport_Homo sapiens_hsa03013	0.34443464
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32368320
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31992213
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31924983
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31459506
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29883225
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.26674329
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25535800
96	Glutathione metabolism_Homo sapiens_hsa00480	0.25200971
97	Serotonergic synapse_Homo sapiens_hsa04726	0.23584619
98	Taste transduction_Homo sapiens_hsa04742	0.20710122
99	Fatty acid elongation_Homo sapiens_hsa00062	0.18833807
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.18397343

RPS10P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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