ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	purine deoxyribonucleotide catabolic process (GO:0009155)	7.12395352
2	ribosomal small subunit assembly (GO:0000028)	5.27870365
3	cell wall macromolecule metabolic process (GO:0044036)	4.86707452
4	base-excision repair, AP site formation (GO:0006285)	4.83169629
5	negative regulation of nitric-oxide synthase activity (GO:0051001)	4.45140392
6	DNA deamination (GO:0045006)	4.41303559
7	regulation of penile erection (GO:0060405)	4.36236280
8	positive regulation of alpha-beta T cell proliferation (GO:0046641)	4.26398103
9	DNA double-strand break processing (GO:0000729)	4.13252618
10	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.96208068
11	negative regulation of thymocyte apoptotic process (GO:0070244)	3.92501930
12	response to interferon-beta (GO:0035456)	3.92175147
13	rRNA catabolic process (GO:0016075)	3.91666166
14	cellular response to interferon-beta (GO:0035458)	3.88405685
15	purine deoxyribonucleotide metabolic process (GO:0009151)	3.87556535
16	nucleotide salvage (GO:0043173)	3.79855848
17	peptidyl-histidine modification (GO:0018202)	3.64377631
18	deoxyribose phosphate catabolic process (GO:0046386)	3.61666313
19	rRNA modification (GO:0000154)	3.56871791
20	rRNA methylation (GO:0031167)	3.53109390
21	regulation of alpha-beta T cell proliferation (GO:0046640)	3.53101115
22	mannosylation (GO:0097502)	3.51058746
23	positive regulation of viral genome replication (GO:0045070)	3.50872980
24	negative thymic T cell selection (GO:0045060)	3.50570568
25	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.50125967
26	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.47656730
27	deoxyribonucleotide catabolic process (GO:0009264)	3.44059667
28	ether lipid metabolic process (GO:0046485)	3.38801514
29	positive regulation of B cell differentiation (GO:0045579)	3.36427005
30	cytokine biosynthetic process (GO:0042089)	3.35326283
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.35018893
32	maturation of 5.8S rRNA (GO:0000460)	3.33342972
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.33186774
34	negative T cell selection (GO:0043383)	3.32050058
35	negative regulation of monooxygenase activity (GO:0032769)	3.30999096
36	ATP synthesis coupled proton transport (GO:0015986)	3.29124810
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29124810
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10272029
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.07887109
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02972522
41	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.01960850
42	organelle disassembly (GO:1903008)	2.99970672
43	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.98923272
44	UMP metabolic process (GO:0046049)	2.98923272
45	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.98923272
46	UMP biosynthetic process (GO:0006222)	2.98923272
47	DNA dealkylation (GO:0035510)	2.97387572
48	regulation of isotype switching to IgG isotypes (GO:0048302)	2.94052593
49	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.92294117
50	glycerol ether metabolic process (GO:0006662)	2.91437208
51	axoneme assembly (GO:0035082)	2.90216305
52	regulation of memory T cell differentiation (GO:0043380)	2.88165546
53	positive regulation of calcium-mediated signaling (GO:0050850)	2.87002486
54	inner ear receptor cell differentiation (GO:0060113)	2.84683956
55	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.83019580
56	negative regulation of T cell apoptotic process (GO:0070233)	2.81612627
57	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.79951706
58	cellular response to prostaglandin stimulus (GO:0071379)	2.79129052
59	regulation of helicase activity (GO:0051095)	2.78899438
60	GPI anchor metabolic process (GO:0006505)	2.78735178
61	cytokine metabolic process (GO:0042107)	2.78307699
62	retinal rod cell development (GO:0046548)	2.77472496
63	phospholipid efflux (GO:0033700)	2.76777164
64	protein neddylation (GO:0045116)	2.73123357
65	protein K11-linked ubiquitination (GO:0070979)	2.72971838
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72810205
67	cellular response to dsRNA (GO:0071359)	2.71597767
68	regulation of defense response to virus by host (GO:0050691)	2.71381019
69	estrogen biosynthetic process (GO:0006703)	2.71120823
70	ether metabolic process (GO:0018904)	2.70206794
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.69475852
72	viral transcription (GO:0019083)	2.69158747
73	ncRNA catabolic process (GO:0034661)	2.68713678
74	positive regulation of chemokine secretion (GO:0090197)	2.66256740
75	sensory perception of taste (GO:0050909)	2.66112785
76	GPI anchor biosynthetic process (GO:0006506)	2.65460219
77	high-density lipoprotein particle remodeling (GO:0034375)	2.65175436
78	translational termination (GO:0006415)	2.64803033
79	regulation of B cell differentiation (GO:0045577)	2.61926774
80	ribonucleoprotein complex disassembly (GO:0032988)	2.61248378
81	regulation of cholesterol esterification (GO:0010872)	2.61020601
82	hair cell differentiation (GO:0035315)	2.58017110
83	replication fork processing (GO:0031297)	2.56963568
84	mechanoreceptor differentiation (GO:0042490)	2.56393894
85	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.55774265
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.53758938
87	viral mRNA export from host cell nucleus (GO:0046784)	2.53294118
88	translational elongation (GO:0006414)	2.52471486
89	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.51125567
90	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51074981
91	regulation of chemokine secretion (GO:0090196)	2.48384988
92	parturition (GO:0007567)	2.48151594
93	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.47238864
94	NADH dehydrogenase complex assembly (GO:0010257)	2.47238864
95	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.47238864
96	protein complex biogenesis (GO:0070271)	2.46926297
97	pyrimidine nucleoside salvage (GO:0043097)	2.46283354
98	pyrimidine-containing compound salvage (GO:0008655)	2.46283354
99	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.45705929
100	regulation of cilium movement (GO:0003352)	2.45477195

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.27159363
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44196009
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.35083604
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.32105313
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30339889
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.25891812
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.91654102
8	VDR_22108803_ChIP-Seq_LS180_Human	2.85772463
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67694155
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.66713006
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.65993770
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.41754185
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.38249415
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31520090
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.28411739
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.25223708
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23341196
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.23067764
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.22869565
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20469750
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.13122338
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08854347
23	EZH2_22144423_ChIP-Seq_EOC_Human	2.07367680
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06407933
25	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.04525268
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97258590
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.83488213
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82641511
29	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.74226378
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.69515397
31	GATA3_26560356_Chip-Seq_TH2_Human	1.57719501
32	AR_20517297_ChIP-Seq_VCAP_Human	1.56863918
33	EWS_26573619_Chip-Seq_HEK293_Human	1.53146733
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50859532
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50382351
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45811239
37	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43837815
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43172420
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42728237
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38604526
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38299667
42	FUS_26573619_Chip-Seq_HEK293_Human	1.35968972
43	MYB_26560356_Chip-Seq_TH2_Human	1.35958753
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33232892
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33138021
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33138021
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.30254585
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30067941
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28247764
50	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.28142124
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27767621
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27180947
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27180947
54	P300_19829295_ChIP-Seq_ESCs_Human	1.21850043
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21270356
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20776655
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.20492995
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19956727
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19312514
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19249017
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16545102
62	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.16121241
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15771668
64	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.14056458
65	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13855551
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.13104356
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11871509
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11838162
69	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09415968
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08819086
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08465230
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08375334
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07662526
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07304336
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05751459
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04974451
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02950490
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.02341642
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02341642
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02208062
81	SMRT_27268052_Chip-Seq_Bcells_Human	1.01038343
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00087732
83	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99959494
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98780577
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98096038
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.96842577
87	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96655907
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96484962
89	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95934302
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.95573178
91	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93164421
92	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.92855209
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.92220987
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91776240
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91442669
96	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91442669
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90860530
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.90775104
99	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.90291205
100	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89991196

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	4.76629227
2	MP0003136_yellow_coat_color	4.08204724
3	MP0001986_abnormal_taste_sensitivity	4.03232325
4	MP0002277_abnormal_respiratory_mucosa	3.51018810
5	MP0004145_abnormal_muscle_electrophysio	3.33848327
6	MP0005671_abnormal_response_to	3.09436952
7	MP0003191_abnormal_cellular_cholesterol	2.73399255
8	MP0002095_abnormal_skin_pigmentation	2.59088046
9	MP0009840_abnormal_foam_cell	2.47968231
10	MP0003763_abnormal_thymus_physiology	2.47039959
11	MP0005075_abnormal_melanosome_morpholog	2.34186633
12	MP0008877_abnormal_DNA_methylation	2.22852339
13	MP0000569_abnormal_digit_pigmentation	2.13855481
14	MP0002138_abnormal_hepatobiliary_system	2.02124539
15	MP0000647_abnormal_sebaceous_gland	1.97172816
16	MP0005551_abnormal_eye_electrophysiolog	1.94453694
17	MP0009697_abnormal_copulation	1.89683696
18	MP0003646_muscle_fatigue	1.83257138
19	MP0002638_abnormal_pupillary_reflex	1.76673893
20	MP0005174_abnormal_tail_pigmentation	1.76518475
21	MP0005670_abnormal_white_adipose	1.65970385
22	MP0002938_white_spotting	1.59652764
23	MP0004381_abnormal_hair_follicle	1.58878778
24	MP0000372_irregular_coat_pigmentation	1.57914497
25	MP0008875_abnormal_xenobiotic_pharmacok	1.55813681
26	MP0005645_abnormal_hypothalamus_physiol	1.49849330
27	MP0009785_altered_susceptibility_to	1.45924047
28	MP0008872_abnormal_physiological_respon	1.43488318
29	MP0003880_abnormal_central_pattern	1.42517191
30	MP0003183_abnormal_peptide_metabolism	1.41059248
31	MP0004147_increased_porphyrin_level	1.39204064
32	MP0005410_abnormal_fertilization	1.35910394
33	MP0009379_abnormal_foot_pigmentation	1.35024480
34	MP0001800_abnormal_humoral_immune	1.33065856
35	MP0005253_abnormal_eye_physiology	1.29008919
36	MP0006054_spinal_hemorrhage	1.28516714
37	MP0002148_abnormal_hypersensitivity_rea	1.27727917
38	MP0006072_abnormal_retinal_apoptosis	1.27687300
39	MP0000427_abnormal_hair_cycle	1.25705571
40	MP0003806_abnormal_nucleotide_metabolis	1.24104490
41	MP0008058_abnormal_DNA_repair	1.21858898
42	MP0005000_abnormal_immune_tolerance	1.20090611
43	MP0003718_maternal_effect	1.18998898
44	MP0002723_abnormal_immune_serum	1.18678557
45	MP0005171_absent_coat_pigmentation	1.17433704
46	MP0002420_abnormal_adaptive_immunity	1.13204173
47	MP0002837_dystrophic_cardiac_calcinosis	1.11234241
48	MP0001819_abnormal_immune_cell	1.10672529
49	MP0005387_immune_system_phenotype	1.08533883
50	MP0001790_abnormal_immune_system	1.08533883
51	MP0003186_abnormal_redox_activity	1.06339549
52	MP0000537_abnormal_urethra_morphology	1.02670819
53	MP0010155_abnormal_intestine_physiology	1.02568392
54	MP0002452_abnormal_antigen_presenting	1.02529364
55	MP0001293_anophthalmia	1.02221653
56	MP0003195_calcinosis	1.01913777
57	MP0002160_abnormal_reproductive_system	1.01210567
58	MP0005365_abnormal_bile_salt	0.98878598
59	MP0005025_abnormal_response_to	0.96944026
60	MP0002398_abnormal_bone_marrow	0.95759926
61	MP0002019_abnormal_tumor_incidence	0.95108534
62	MP0002751_abnormal_autonomic_nervous	0.94104944
63	MP0003693_abnormal_embryo_hatching	0.93941115
64	MP0005389_reproductive_system_phenotype	0.91980207
65	MP0002693_abnormal_pancreas_physiology	0.90856496
66	MP0006276_abnormal_autonomic_nervous	0.90652889
67	MP0001243_abnormal_dermal_layer	0.90059722
68	MP0000716_abnormal_immune_system	0.89552651
69	MP0000604_amyloidosis	0.89528184
70	MP0001119_abnormal_female_reproductive	0.89337686
71	MP0001835_abnormal_antigen_presentation	0.88065362
72	MP0008007_abnormal_cellular_replicative	0.87669937
73	MP0000685_abnormal_immune_system	0.85514870
74	MP0009765_abnormal_xenobiotic_induced	0.85146257
75	MP0008469_abnormal_protein_level	0.84995869
76	MP0001929_abnormal_gametogenesis	0.84837351
77	MP0006082_CNS_inflammation	0.78767962
78	MP0003252_abnormal_bile_duct	0.77241964
79	MP0002653_abnormal_ependyma_morphology	0.75814100
80	MP0006036_abnormal_mitochondrial_physio	0.75060289
81	MP0009764_decreased_sensitivity_to	0.73449665
82	MP0001845_abnormal_inflammatory_respons	0.73176642
83	MP0009333_abnormal_splenocyte_physiolog	0.72311417
84	MP0004019_abnormal_vitamin_homeostasis	0.72223064
85	MP0010094_abnormal_chromosome_stability	0.71371429
86	MP0000516_abnormal_urinary_system	0.70622256
87	MP0005367_renal/urinary_system_phenotyp	0.70622256
88	MP0004742_abnormal_vestibular_system	0.69479115
89	MP0002429_abnormal_blood_cell	0.67805076
90	MP0002736_abnormal_nociception_after	0.67631728
91	MP0000689_abnormal_spleen_morphology	0.67583708
92	MP0001968_abnormal_touch/_nociception	0.67544811
93	MP0005595_abnormal_vascular_smooth	0.66773033
94	MP0000703_abnormal_thymus_morphology	0.66734576
95	MP0010329_abnormal_lipoprotein_level	0.65877983
96	MP0000653_abnormal_sex_gland	0.65580822
97	MP0003787_abnormal_imprinting	0.64050012
98	MP0000026_abnormal_inner_ear	0.63982667
99	MP0001963_abnormal_hearing_physiology	0.63317996
100	MP0009643_abnormal_urine_homeostasis	0.62851796

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.40476632
2	Hyperalaninemia (HP:0003348)	4.40476632
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.40476632
4	True hermaphroditism (HP:0010459)	4.19343348
5	Colon cancer (HP:0003003)	4.10334231
6	Agammaglobulinemia (HP:0004432)	4.03827878
7	Type 2 muscle fiber atrophy (HP:0003554)	3.59156497
8	Stomach cancer (HP:0012126)	3.56389731
9	Pancreatic cysts (HP:0001737)	3.55160963
10	Chronic hepatic failure (HP:0100626)	3.53360450
11	Type I transferrin isoform profile (HP:0003642)	3.52439118
12	Pancreatic fibrosis (HP:0100732)	3.50507457
13	B lymphocytopenia (HP:0010976)	3.09133825
14	Increased intramyocellular lipid droplets (HP:0012240)	3.04560919
15	Attenuation of retinal blood vessels (HP:0007843)	3.04302168
16	Global brain atrophy (HP:0002283)	2.94551500
17	Molar tooth sign on MRI (HP:0002419)	2.92184315
18	Abnormality of midbrain morphology (HP:0002418)	2.92184315
19	Abnormality of B cell number (HP:0010975)	2.92135432
20	Muscle fiber atrophy (HP:0100295)	2.89874521
21	Increased CSF lactate (HP:0002490)	2.81690129
22	Congenital stationary night blindness (HP:0007642)	2.74662879
23	Acute necrotizing encephalopathy (HP:0006965)	2.73750734
24	T lymphocytopenia (HP:0005403)	2.64468788
25	Hyperglycinemia (HP:0002154)	2.60584666
26	Cystic liver disease (HP:0006706)	2.58761806
27	Mitochondrial inheritance (HP:0001427)	2.56498124
28	Increased muscle lipid content (HP:0009058)	2.56315535
29	Aplastic anemia (HP:0001915)	2.54581769
30	Severe combined immunodeficiency (HP:0004430)	2.54333777
31	Medial flaring of the eyebrow (HP:0010747)	2.46687076
32	Increased hepatocellular lipid droplets (HP:0006565)	2.46448715
33	Increased serum lactate (HP:0002151)	2.44462868
34	Spastic paraparesis (HP:0002313)	2.42762709
35	Acute encephalopathy (HP:0006846)	2.40481310
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40330483
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39821673
38	Autoimmune thrombocytopenia (HP:0001973)	2.37332928
39	Abnormal protein glycosylation (HP:0012346)	2.34920034
40	Abnormal glycosylation (HP:0012345)	2.34920034
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.34920034
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.34920034
43	Hypoplasia of the uterus (HP:0000013)	2.34552009
44	Abnormality of T cell number (HP:0011839)	2.34167741
45	Respiratory difficulties (HP:0002880)	2.30175194
46	Thyroiditis (HP:0100646)	2.24745009
47	Autoimmune hemolytic anemia (HP:0001890)	2.22077013
48	Reduced antithrombin III activity (HP:0001976)	2.17328035
49	Bile duct proliferation (HP:0001408)	2.16282421
50	Abnormal biliary tract physiology (HP:0012439)	2.16282421
51	Renal cortical cysts (HP:0000803)	2.15515539
52	Abolished electroretinogram (ERG) (HP:0000550)	2.15418935
53	Decreased central vision (HP:0007663)	2.15231509
54	Azoospermia (HP:0000027)	2.15081605
55	Progressive macrocephaly (HP:0004481)	2.14724040
56	Congenital primary aphakia (HP:0007707)	2.14679993
57	Hepatocellular necrosis (HP:0001404)	2.14089733
58	Abnormality of serum amino acid levels (HP:0003112)	2.14003962
59	3-Methylglutaconic aciduria (HP:0003535)	2.13637761
60	IgG deficiency (HP:0004315)	2.12777290
61	Methylmalonic acidemia (HP:0002912)	2.12367385
62	Spontaneous abortion (HP:0005268)	2.12216387
63	Methylmalonic aciduria (HP:0012120)	2.11534464
64	Encephalitis (HP:0002383)	2.09756142
65	Hypoplasia of the pons (HP:0012110)	2.09283238
66	Abnormality of the renal cortex (HP:0011035)	2.09074688
67	Nephronophthisis (HP:0000090)	2.08407457
68	Abnormal number of erythroid precursors (HP:0012131)	2.08009765
69	Nephrogenic diabetes insipidus (HP:0009806)	2.06406760
70	Hematochezia (HP:0002573)	2.06208045
71	Gait imbalance (HP:0002141)	2.06017263
72	Lipid accumulation in hepatocytes (HP:0006561)	2.05173817
73	Male pseudohermaphroditism (HP:0000037)	2.03891398
74	Congenital sensorineural hearing impairment (HP:0008527)	2.02962313
75	Renal Fanconi syndrome (HP:0001994)	2.01832579
76	Lactic acidosis (HP:0003128)	2.01770932
77	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01626295
78	Anhidrosis (HP:0000970)	2.00850175
79	Sclerocornea (HP:0000647)	1.99590941
80	Abnormality of the anterior horn cell (HP:0006802)	1.98880031
81	Degeneration of anterior horn cells (HP:0002398)	1.98880031
82	Combined immunodeficiency (HP:0005387)	1.97706744
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97490088
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.97490088
85	Chronic otitis media (HP:0000389)	1.95049647
86	Asplenia (HP:0001746)	1.94939281
87	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93494966
88	Vaginal atresia (HP:0000148)	1.92010987
89	Intestinal atresia (HP:0011100)	1.90001869
90	Postaxial foot polydactyly (HP:0001830)	1.89282038
91	Anencephaly (HP:0002323)	1.87573831
92	Exertional dyspnea (HP:0002875)	1.85995730
93	Panhypogammaglobulinemia (HP:0003139)	1.85292719
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84569205
95	Weak cry (HP:0001612)	1.84136811
96	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.84070193
97	Abnormality of cells of the erythroid lineage (HP:0012130)	1.83698745
98	Abnormality of the pons (HP:0007361)	1.83151338
99	Malignant hyperthermia (HP:0002047)	1.82951619
100	Genital tract atresia (HP:0001827)	1.81392465

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	7.81044394
2	TESK2	6.85622168
3	TXK	4.05544571
4	ACVR1B	2.98834525
5	PBK	2.60073944
6	RIPK1	2.16347907
7	VRK2	2.13489607
8	BUB1	2.08227419
9	VRK1	1.97658764
10	IKBKE	1.87156196
11	ITK	1.81694086
12	KIT	1.76365207
13	NLK	1.70360460
14	PDK2	1.68339673
15	ADRBK2	1.68146824
16	TYK2	1.63540039
17	PASK	1.62620455
18	BMPR1B	1.59881959
19	ZAK	1.56836756
20	NUAK1	1.56059763
21	MKNK1	1.47372198
22	TRIM28	1.38085577
23	FLT3	1.26493655
24	STK16	1.26183978
25	TLK1	1.22767349
26	WNK3	1.22622557
27	MAP4K1	1.22374591
28	DYRK3	1.22332720
29	TBK1	1.21647103
30	TAF1	1.18638973
31	MKNK2	1.13393323
32	GRK1	1.11723831
33	BCR	1.02098216
34	TNIK	0.99788312
35	TEC	0.99720665
36	MAPK13	0.98629169
37	TAOK3	0.97010329
38	KDR	0.94373007
39	ALK	0.90713969
40	PIK3CA	0.80535177
41	TGFBR1	0.78185568
42	IKBKB	0.77909061
43	NTRK2	0.75029029
44	FRK	0.74848360
45	SCYL2	0.71174800
46	IRAK4	0.69466402
47	PRKCQ	0.68127885
48	CDC7	0.66914372
49	PINK1	0.66855103
50	DYRK2	0.65512622
51	SYK	0.61861694
52	PIM2	0.58871222
53	RPS6KA5	0.58278954
54	TTK	0.57356870
55	BTK	0.54619726
56	PLK3	0.52040237
57	INSRR	0.51987436
58	TSSK6	0.51420572
59	CDK19	0.49898857
60	LCK	0.49491613
61	CDK8	0.46473200
62	GRK7	0.45500351
63	ATR	0.44315277
64	PRKCG	0.43093525
65	PLK4	0.42067378
66	PLK1	0.41480548
67	CAMKK1	0.39765325
68	JAK1	0.39743888
69	MAP3K4	0.39340711
70	LYN	0.38236915
71	RPS6KA4	0.38056482
72	ERBB3	0.37634703
73	IGF1R	0.37352470
74	BMPR2	0.36551749
75	MAP3K5	0.34732339
76	PIM1	0.33954509
77	MST4	0.33019650
78	EPHA4	0.32270354
79	IRAK1	0.30510870
80	BRSK2	0.29234749
81	ADRBK1	0.28930425
82	OBSCN	0.28840321
83	CSNK2A1	0.26445575
84	TYRO3	0.25767129
85	MELK	0.25100226
86	CSNK2A2	0.24900228
87	ARAF	0.23259469
88	PRKCB	0.22868189
89	MAP4K2	0.22295214
90	IRAK2	0.21270075
91	PRKCH	0.21174012
92	RIPK4	0.21083810
93	CSF1R	0.18716510
94	PAK1	0.18335201
95	TIE1	0.18288862
96	CSK	0.18261949
97	CSNK1A1	0.18155266
98	AURKA	0.17870130
99	MARK3	0.17856861
100	LIMK1	0.17265416

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.65777987
2	Proteasome_Homo sapiens_hsa03050	3.10929055
3	Ribosome_Homo sapiens_hsa03010	2.98470172
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.97775144
5	Caffeine metabolism_Homo sapiens_hsa00232	2.53769575
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44102367
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40053972
8	Homologous recombination_Homo sapiens_hsa03440	2.32168071
9	RNA degradation_Homo sapiens_hsa03018	2.26708798
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18141435
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09648958
12	Parkinsons disease_Homo sapiens_hsa05012	2.07150093
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.98248445
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.80163768
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.66003216
16	Phototransduction_Homo sapiens_hsa04744	1.57027236
17	Basal transcription factors_Homo sapiens_hsa03022	1.47117649
18	RNA polymerase_Homo sapiens_hsa03020	1.42066307
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.41860099
20	Propanoate metabolism_Homo sapiens_hsa00640	1.40033832
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.39160903
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.38622920
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36550829
24	Taste transduction_Homo sapiens_hsa04742	1.35592959
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.33654747
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.33054956
27	Peroxisome_Homo sapiens_hsa04146	1.33024059
28	Allograft rejection_Homo sapiens_hsa05330	1.32570782
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.30096138
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.29864500
31	Fatty acid elongation_Homo sapiens_hsa00062	1.28481864
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28128673
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.26811999
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.22900090
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.22076667
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22033224
37	Butanoate metabolism_Homo sapiens_hsa00650	1.20687321
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19714342
39	Graft-versus-host disease_Homo sapiens_hsa05332	1.16471439
40	Retinol metabolism_Homo sapiens_hsa00830	1.14516984
41	Protein export_Homo sapiens_hsa03060	1.12186122
42	Base excision repair_Homo sapiens_hsa03410	1.11330386
43	Huntingtons disease_Homo sapiens_hsa05016	1.09199099
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05211524
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03233270
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.00570572
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99260947
48	One carbon pool by folate_Homo sapiens_hsa00670	0.98745929
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94811596
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93012682
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.92508495
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92409984
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92376507
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92069655
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90158947
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.88461409
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.88095681
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87672320
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87452671
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86516288
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86250007
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84985204
63	Alzheimers disease_Homo sapiens_hsa05010	0.84731297
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.83775244
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80642521
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79607965
67	Purine metabolism_Homo sapiens_hsa00230	0.79239476
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77454930
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74291238
70	RNA transport_Homo sapiens_hsa03013	0.74019403
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72414936
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70616681
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69364107
74	Metabolic pathways_Homo sapiens_hsa01100	0.67181369
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67012715
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.65535947
77	Olfactory transduction_Homo sapiens_hsa04740	0.65524676
78	Fatty acid degradation_Homo sapiens_hsa00071	0.62967760
79	Asthma_Homo sapiens_hsa05310	0.62300760
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59811182
81	Glutathione metabolism_Homo sapiens_hsa00480	0.55640239
82	Rheumatoid arthritis_Homo sapiens_hsa05323	0.55333177
83	Regulation of autophagy_Homo sapiens_hsa04140	0.54844645
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52089532
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49903237
86	Spliceosome_Homo sapiens_hsa03040	0.49414014
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.46384908
88	Carbon metabolism_Homo sapiens_hsa01200	0.44370416
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43915778
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.43157455
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42094627
92	Sulfur metabolism_Homo sapiens_hsa00920	0.41043396
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39746851
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.39644254
95	Measles_Homo sapiens_hsa05162	0.35002543
96	Mismatch repair_Homo sapiens_hsa03430	0.33951136
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33817243
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32972425
99	Nicotine addiction_Homo sapiens_hsa05033	0.32176731
100	ABC transporters_Homo sapiens_hsa02010	0.29001446

RPS10P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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