RPS10P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.90104193
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.90104193
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72868409
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.69834563
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.69834563
6negative regulation of telomere maintenance (GO:0032205)4.67679969
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61051020
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.61051020
9NADH dehydrogenase complex assembly (GO:0010257)4.61051020
10protein complex biogenesis (GO:0070271)4.48927420
11ribosomal small subunit assembly (GO:0000028)4.34630620
12natural killer cell activation involved in immune response (GO:0002323)4.28927834
13mitochondrial respiratory chain complex assembly (GO:0033108)4.20464065
14positive regulation of prostaglandin secretion (GO:0032308)4.06646104
15viral transcription (GO:0019083)4.02011793
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96334825
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.93891786
18translational termination (GO:0006415)3.90123802
19maturation of 5.8S rRNA (GO:0000460)3.83312522
20electron transport chain (GO:0022900)3.78555346
21respiratory electron transport chain (GO:0022904)3.76991263
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71662030
23proteasome assembly (GO:0043248)3.66743050
24protein targeting to ER (GO:0045047)3.62690330
25cotranslational protein targeting to membrane (GO:0006613)3.61576052
26respiratory chain complex IV assembly (GO:0008535)3.49909967
27protein localization to endoplasmic reticulum (GO:0070972)3.47099507
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43582581
29translational elongation (GO:0006414)3.39563167
30L-fucose catabolic process (GO:0042355)3.32840975
31fucose catabolic process (GO:0019317)3.32840975
32L-fucose metabolic process (GO:0042354)3.32840975
33response to pheromone (GO:0019236)3.32670482
34ATP biosynthetic process (GO:0006754)3.29381899
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25356123
36water-soluble vitamin biosynthetic process (GO:0042364)3.22838354
37positive regulation of defense response to virus by host (GO:0002230)3.20049519
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17587777
39phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16262347
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15405921
41cellular response to interferon-beta (GO:0035458)3.13508627
42regulation of prostaglandin secretion (GO:0032306)3.12351203
43DNA deamination (GO:0045006)3.12057378
44response to interferon-beta (GO:0035456)3.10760543
45pseudouridine synthesis (GO:0001522)3.07598310
46production of molecular mediator of immune response (GO:0002440)3.06202477
47mast cell activation (GO:0045576)3.05372547
48rRNA catabolic process (GO:0016075)3.03913133
49viral life cycle (GO:0019058)3.01597706
50mismatch repair (GO:0006298)2.98295948
51cytochrome complex assembly (GO:0017004)2.95255230
52chaperone-mediated protein transport (GO:0072321)2.95008812
53protein neddylation (GO:0045116)2.91510289
54spliceosomal complex assembly (GO:0000245)2.88516683
55hydrogen ion transmembrane transport (GO:1902600)2.88489250
56positive regulation of fatty acid transport (GO:2000193)2.87703088
57translational initiation (GO:0006413)2.87103029
58regulation of T cell mediated cytotoxicity (GO:0001914)2.86582051
59rRNA modification (GO:0000154)2.84701544
60folic acid-containing compound biosynthetic process (GO:0009396)2.82717544
61translation (GO:0006412)2.82483939
62phosphatidylserine acyl-chain remodeling (GO:0036150)2.82273935
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.81583641
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81583641
65GTP biosynthetic process (GO:0006183)2.80239721
66regulation of helicase activity (GO:0051095)2.79823668
67leukotriene biosynthetic process (GO:0019370)2.78306155
68preassembly of GPI anchor in ER membrane (GO:0016254)2.76346768
69lymph node development (GO:0048535)2.76286327
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75310685
71piRNA metabolic process (GO:0034587)2.75003621
72cellular protein complex disassembly (GO:0043624)2.74767571
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73658875
74proton transport (GO:0015992)2.71890539
75platelet dense granule organization (GO:0060155)2.70151823
76DNA catabolic process, exonucleolytic (GO:0000738)2.68020891
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67290811
78spliceosomal snRNP assembly (GO:0000387)2.67252575
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66068115
80ribosomal small subunit biogenesis (GO:0042274)2.65918651
81regulation of cellular amino acid metabolic process (GO:0006521)2.64355175
82hydrogen transport (GO:0006818)2.63639878
83cardiac left ventricle morphogenesis (GO:0003214)2.62926889
84positive regulation of icosanoid secretion (GO:0032305)2.61417664
85tRNA processing (GO:0008033)2.60759870
86phosphate ion homeostasis (GO:0055062)2.60355038
87trivalent inorganic anion homeostasis (GO:0072506)2.60355038
88cellular response to interleukin-15 (GO:0071350)2.60154238
89negative regulation of cell killing (GO:0031342)2.57219107
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57219107
91maturation of SSU-rRNA (GO:0030490)2.56075411
92immunoglobulin mediated immune response (GO:0016064)2.53783700
93negative regulation of B cell apoptotic process (GO:0002903)2.53281772
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52634956
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52634956
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52634956
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52596351
98endoderm formation (GO:0001706)2.51413664
99ribonucleoside triphosphate biosynthetic process (GO:0009201)2.50674479
100protein-cofactor linkage (GO:0018065)2.49811208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.45659109
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.77647156
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50805044
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18932959
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11109527
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.09326196
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06287523
8VDR_23849224_ChIP-Seq_CD4+_Human3.03805134
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97261112
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93839755
11ELK1_19687146_ChIP-ChIP_HELA_Human2.61964416
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56252351
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45942434
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.39452385
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32234220
16FOXP3_21729870_ChIP-Seq_TREG_Human2.27912741
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19448868
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.19060239
19ZNF274_21170338_ChIP-Seq_K562_Hela2.16885661
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.15975068
21VDR_22108803_ChIP-Seq_LS180_Human2.11415869
22IRF1_19129219_ChIP-ChIP_H3396_Human2.08134700
23IGF1R_20145208_ChIP-Seq_DFB_Human1.88025029
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85088889
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83763188
26TAF15_26573619_Chip-Seq_HEK293_Human1.79476496
27MYC_18940864_ChIP-ChIP_HL60_Human1.73675570
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66759829
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65475458
30TP53_22573176_ChIP-Seq_HFKS_Human1.62897844
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.62047290
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61209098
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60010830
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59293854
35GATA3_26560356_Chip-Seq_TH2_Human1.58781007
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58597480
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57447548
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54961602
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54846758
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53603666
41DCP1A_22483619_ChIP-Seq_HELA_Human1.50211117
42AR_20517297_ChIP-Seq_VCAP_Human1.49231548
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44397258
44ER_23166858_ChIP-Seq_MCF-7_Human1.42836684
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.42771614
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40343185
47SOX2_19829295_ChIP-Seq_ESCs_Human1.37942306
48NANOG_19829295_ChIP-Seq_ESCs_Human1.37942306
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.37294066
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37294066
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.34644415
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32651712
53TTF2_22483619_ChIP-Seq_HELA_Human1.31460054
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.30891757
55EWS_26573619_Chip-Seq_HEK293_Human1.29893346
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28725457
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26539092
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25970810
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25122743
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24631143
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23944303
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23657444
63STAT1_20625510_ChIP-Seq_HELA_Human1.22999550
64GABP_19822575_ChIP-Seq_HepG2_Human1.20550495
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20300390
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19849558
67FUS_26573619_Chip-Seq_HEK293_Human1.15705754
68NANOG_20526341_ChIP-Seq_ESCs_Human1.14950228
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12924523
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12122703
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09653895
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08058981
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06143280
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04913758
75P300_19829295_ChIP-Seq_ESCs_Human1.04574655
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04436884
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01899737
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01609733
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.01177081
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01001750
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00765713
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00024325
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99243537
84ERG_20517297_ChIP-Seq_VCAP_Human0.98816628
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98381713
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98365993
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96539196
88HOXB7_26014856_ChIP-Seq_BT474_Human0.94810256
89TAF2_19829295_ChIP-Seq_ESCs_Human0.94760908
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.90508884
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.90396890
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89864677
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89183608
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89170056
95CIITA_25753668_ChIP-Seq_RAJI_Human0.88701791
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88005128
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87601585
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87581370
99MYB_26560356_Chip-Seq_TH2_Human0.87368928
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86753906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.84961439
2MP0008877_abnormal_DNA_methylation3.54609919
3MP0009379_abnormal_foot_pigmentation2.88686748
4MP0003195_calcinosis2.69739176
5MP0006054_spinal_hemorrhage2.56260087
6MP0004147_increased_porphyrin_level2.55947473
7MP0008995_early_reproductive_senescence2.44817343
8MP0008875_abnormal_xenobiotic_pharmacok2.30363612
9MP0002837_dystrophic_cardiac_calcinosis2.28624255
10MP0003786_premature_aging2.22896585
11MP0002148_abnormal_hypersensitivity_rea2.15765872
12MP0001835_abnormal_antigen_presentation2.15544152
13MP0002876_abnormal_thyroid_physiology2.14358739
14MP0006072_abnormal_retinal_apoptosis2.04380132
15MP0002102_abnormal_ear_morphology1.91675078
16MP0002254_reproductive_system_inflammat1.88860705
17MP0003806_abnormal_nucleotide_metabolis1.87020629
18MP0001873_stomach_inflammation1.85449918
19MP0005379_endocrine/exocrine_gland_phen1.84069843
20MP0005671_abnormal_response_to1.82717270
21MP0005167_abnormal_blood-brain_barrier1.80980063
22MP0008872_abnormal_physiological_respon1.78528641
23MP0003718_maternal_effect1.78151289
24MP0002163_abnormal_gland_morphology1.75269626
25MP0002638_abnormal_pupillary_reflex1.72718256
26MP0006292_abnormal_olfactory_placode1.66605431
27MP0001986_abnormal_taste_sensitivity1.65679934
28MP0008058_abnormal_DNA_repair1.64105141
29MP0003186_abnormal_redox_activity1.58438878
30MP0005551_abnormal_eye_electrophysiolog1.52954340
31MP0000613_abnormal_salivary_gland1.48243924
32MP0001485_abnormal_pinna_reflex1.45521470
33MP0005084_abnormal_gallbladder_morpholo1.44466872
34MP0001968_abnormal_touch/_nociception1.40722060
35MP0008775_abnormal_heart_ventricle1.40375070
36MP0001800_abnormal_humoral_immune1.40187307
37MP0005085_abnormal_gallbladder_physiolo1.38802537
38MP0005645_abnormal_hypothalamus_physiol1.37765895
39MP0003878_abnormal_ear_physiology1.37239806
40MP0005377_hearing/vestibular/ear_phenot1.37239806
41MP0005253_abnormal_eye_physiology1.35440209
42MP0005646_abnormal_pituitary_gland1.34282216
43MP0002166_altered_tumor_susceptibility1.31964313
44MP0005332_abnormal_amino_acid1.31237441
45MP0001501_abnormal_sleep_pattern1.30825914
46MP0001727_abnormal_embryo_implantation1.29594384
47MP0005367_renal/urinary_system_phenotyp1.29286874
48MP0000516_abnormal_urinary_system1.29286874
49MP0002736_abnormal_nociception_after1.27530387
50MP0003787_abnormal_imprinting1.25093999
51MP0002277_abnormal_respiratory_mucosa1.22446368
52MP0004885_abnormal_endolymph1.20753930
53MP0006035_abnormal_mitochondrial_morpho1.15626995
54MP0000427_abnormal_hair_cycle1.15520015
55MP0001348_abnormal_lacrimal_gland1.15230113
56MP0002938_white_spotting1.10658861
57MP0002452_abnormal_antigen_presenting1.10603233
58MP0002234_abnormal_pharynx_morphology1.08698845
59MP0000013_abnormal_adipose_tissue1.08411147
60MP0001486_abnormal_startle_reflex1.07617502
61MP0005000_abnormal_immune_tolerance1.06997632
62MP0009764_decreased_sensitivity_to1.06907465
63MP0003763_abnormal_thymus_physiology1.05894263
64MP0001919_abnormal_reproductive_system1.05432417
65MP0004142_abnormal_muscle_tone1.01465724
66MP0001819_abnormal_immune_cell1.00570003
67MP0004043_abnormal_pH_regulation1.00120183
68MP0005075_abnormal_melanosome_morpholog0.99087381
69MP0009785_altered_susceptibility_to0.97648295
70MP0002723_abnormal_immune_serum0.97548966
71MP0002420_abnormal_adaptive_immunity0.95896480
72MP0002272_abnormal_nervous_system0.95301121
73MP0003011_delayed_dark_adaptation0.95113173
74MP0001666_abnormal_nutrient_absorption0.94551003
75MP0002006_tumorigenesis0.94354598
76MP0003567_abnormal_fetal_cardiomyocyte0.94063221
77MP0001853_heart_inflammation0.93998345
78MP0009643_abnormal_urine_homeostasis0.92155136
79MP0002396_abnormal_hematopoietic_system0.91858801
80MP0003638_abnormal_response/metabolism_0.91674063
81MP0010155_abnormal_intestine_physiology0.89462863
82MP0004742_abnormal_vestibular_system0.88686561
83MP0005387_immune_system_phenotype0.86041899
84MP0001790_abnormal_immune_system0.86041899
85MP0004084_abnormal_cardiac_muscle0.85592403
86MP0006036_abnormal_mitochondrial_physio0.85034793
87MP0001188_hyperpigmentation0.83826297
88MP0003646_muscle_fatigue0.82764525
89MP0004145_abnormal_muscle_electrophysio0.82071284
90MP0004484_altered_response_of0.80949470
91MP0009333_abnormal_splenocyte_physiolog0.79298905
92MP0003252_abnormal_bile_duct0.78201891
93MP0001765_abnormal_ion_homeostasis0.77216374
94MP0005636_abnormal_mineral_homeostasis0.74648190
95MP0001845_abnormal_inflammatory_respons0.73940595
96MP0008961_abnormal_basal_metabolism0.73373275
97MP0000716_abnormal_immune_system0.72312731
98MP0000689_abnormal_spleen_morphology0.70028097
99MP0003724_increased_susceptibility_to0.69017325
100MP0008007_abnormal_cellular_replicative0.68954604

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)5.45178359
2Acute necrotizing encephalopathy (HP:0006965)4.20704505
3Prostate neoplasm (HP:0100787)3.97507802
4Acute encephalopathy (HP:0006846)3.84532515
5Mitochondrial inheritance (HP:0001427)3.64353524
6Abnormal mitochondria in muscle tissue (HP:0008316)3.60908698
7Progressive macrocephaly (HP:0004481)3.56430762
8Pancreatic cysts (HP:0001737)3.48899874
9Congenital stationary night blindness (HP:0007642)3.37575403
10Increased CSF lactate (HP:0002490)3.33394460
11Type II lissencephaly (HP:0007260)3.30362575
12Abnormal number of erythroid precursors (HP:0012131)3.28975311
13Aplastic anemia (HP:0001915)3.28524018
143-Methylglutaconic aciduria (HP:0003535)3.20522827
15Abnormality of cells of the erythroid lineage (HP:0012130)3.15479253
16Hepatocellular necrosis (HP:0001404)3.14684212
17Molar tooth sign on MRI (HP:0002419)3.12449640
18Abnormality of midbrain morphology (HP:0002418)3.12449640
19Abnormality of secondary sexual hair (HP:0009888)2.94291373
20Abnormality of the axillary hair (HP:0100134)2.94291373
21Severe combined immunodeficiency (HP:0004430)2.93954267
22IgG deficiency (HP:0004315)2.93427307
23Abnormality of the prostate (HP:0008775)2.93184806
24Testicular atrophy (HP:0000029)2.90927183
25Elevated erythrocyte sedimentation rate (HP:0003565)2.87408292
26Increased hepatocellular lipid droplets (HP:0006565)2.74689612
27B lymphocytopenia (HP:0010976)2.73607219
28Delayed CNS myelination (HP:0002188)2.70954642
29Abnormal biliary tract physiology (HP:0012439)2.70050206
30Bile duct proliferation (HP:0001408)2.70050206
31Lipid accumulation in hepatocytes (HP:0006561)2.69915252
32Nephronophthisis (HP:0000090)2.68974481
33Hepatic necrosis (HP:0002605)2.58799013
34Meckel diverticulum (HP:0002245)2.58657328
35Thyroiditis (HP:0100646)2.55056570
36Abnormality of B cell number (HP:0010975)2.53270369
37Methylmalonic acidemia (HP:0002912)2.52020688
38Renal cortical cysts (HP:0000803)2.47468219
39Pancreatic fibrosis (HP:0100732)2.46013206
40Abnormality of the ileum (HP:0001549)2.45838093
41Cerebral edema (HP:0002181)2.44683948
42Abolished electroretinogram (ERG) (HP:0000550)2.41843039
43True hermaphroditism (HP:0010459)2.41299374
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38455995
45Polydipsia (HP:0001959)2.38187035
46Abnormal drinking behavior (HP:0030082)2.38187035
47Combined immunodeficiency (HP:0005387)2.34867801
48Abnormality of eosinophils (HP:0001879)2.34585718
49Lactic acidosis (HP:0003128)2.30984393
50Pancytopenia (HP:0001876)2.30091961
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.24242219
52Oral leukoplakia (HP:0002745)2.21626772
53Abnormality of the renal cortex (HP:0011035)2.21318362
54Abnormal albumin level (HP:0012116)2.21272515
55Hypoalbuminemia (HP:0003073)2.21272515
56Reticulocytopenia (HP:0001896)2.19933751
57Woolly hair (HP:0002224)2.19931829
58Methylmalonic aciduria (HP:0012120)2.19781186
59Cerebellar dysplasia (HP:0007033)2.18234625
60Abnormality of proline metabolism (HP:0010907)2.18141215
61Hydroxyprolinuria (HP:0003080)2.18141215
62Hyperglycinuria (HP:0003108)2.16882675
63Type I transferrin isoform profile (HP:0003642)2.12360950
64Optic disc pallor (HP:0000543)2.12133196
65Retinal dysplasia (HP:0007973)2.12047755
66Clubbing of toes (HP:0100760)2.10989028
67Prolonged neonatal jaundice (HP:0006579)2.07308716
68Porencephaly (HP:0002132)2.03306565
69Macrocytic anemia (HP:0001972)2.02632246
70Reduced antithrombin III activity (HP:0001976)2.01808715
71Dry hair (HP:0011359)2.00884953
72Abnormal rod and cone electroretinograms (HP:0008323)1.99758257
73Lethargy (HP:0001254)1.97208348
74Bilateral microphthalmos (HP:0007633)1.96739875
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96604661
76Increased serum lactate (HP:0002151)1.96595062
77Stomach cancer (HP:0012126)1.95408819
78Abnormality of male internal genitalia (HP:0000022)1.93806421
79Conical tooth (HP:0000698)1.93138959
80Stomatitis (HP:0010280)1.92553914
81Chromsome breakage (HP:0040012)1.92291854
82Leukodystrophy (HP:0002415)1.92240435
83Aplasia/hypoplasia of the uterus (HP:0008684)1.91785139
84Hypomagnesemia (HP:0002917)1.91318223
85Renal Fanconi syndrome (HP:0001994)1.90645468
86Abnormality of serine family amino acid metabolism (HP:0010894)1.89688598
87Abnormality of glycine metabolism (HP:0010895)1.89688598
88Abnormality of the renal medulla (HP:0100957)1.88004275
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86650423
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.85257323
91Hyperglycinemia (HP:0002154)1.85122147
92Hyperphosphaturia (HP:0003109)1.84493868
93Abnormality of the preputium (HP:0100587)1.83851762
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83181463
95Abnormality of alanine metabolism (HP:0010916)1.83181463
96Hyperalaninemia (HP:0003348)1.83181463
97Abnormal protein glycosylation (HP:0012346)1.82399479
98Abnormal glycosylation (HP:0012345)1.82399479
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82399479
100Abnormal protein N-linked glycosylation (HP:0012347)1.82399479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.20290907
2TXK3.98518699
3ZAK3.73009977
4TIE13.26118109
5GRK13.23165318
6STK162.94911369
7TAOK32.49842205
8BMPR1B2.28086859
9KIT2.25073149
10BCKDK2.17235830
11VRK22.10637057
12WNK42.10489833
13ADRBK22.03049857
14NME21.87475341
15MAP4K11.80806869
16NME11.74936975
17CLK11.74440352
18TSSK61.71667178
19BMPR21.71225388
20NUAK11.67484248
21RIPK41.56366894
22OXSR11.55241540
23EIF2AK11.51150696
24GRK61.48217247
25VRK11.45886076
26TYK21.43606940
27MKNK11.38671458
28FRK1.37742894
29SRPK11.35432989
30FES1.33169479
31TAF11.29749158
32STK41.28444935
33EIF2AK31.21808218
34PHKG11.20498933
35PHKG21.20498933
36NEK11.20230295
37TEC1.17988263
38RPS6KA51.17166734
39IKBKB1.15667178
40IKBKE1.13594333
41STK391.13284529
42SCYL21.09350354
43CSF1R1.06000422
44MAPKAPK51.02680242
45MAP4K21.00170899
46EIF2AK20.97240939
47PBK0.96786931
48MAP3K140.93767352
49BRD40.91925805
50WNK30.84834275
51TNK20.82632143
52JAK10.78554837
53CHUK0.77230106
54PLK20.74671401
55SYK0.74338432
56MET0.72894007
57HCK0.69617088
58FLT30.67950570
59EPHA30.67596030
60INSRR0.66471869
61PLK30.64747380
62CDK190.64639261
63PASK0.62939511
64LYN0.62428982
65MST40.61786953
66ITK0.59281252
67ALK0.58981308
68IRAK10.53939992
69TTK0.52755677
70ADRBK10.52356296
71IGF1R0.51426780
72STK30.50710090
73TNIK0.50536269
74PRKCI0.48415179
75MKNK20.47079285
76PTK2B0.46911121
77NTRK30.46380056
78NLK0.45118510
79PRKCE0.44719226
80FER0.43731635
81ZAP700.40081849
82CDC70.35740362
83EPHA40.34195730
84LCK0.33354400
85CSNK1A10.33019265
86CSNK2A20.32827743
87CSNK2A10.31480022
88JAK30.29873529
89CSNK1G30.29834812
90PAK30.29089205
91BTK0.28915507
92CSNK1G10.28531667
93ATR0.28477498
94PIM10.28034988
95PLK10.27967014
96TGFBR10.27758821
97BUB10.27598951
98AURKB0.26777355
99PRKCQ0.26702734
100CSNK1G20.26152403

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.41718947
2Asthma_Homo sapiens_hsa053103.32109286
3Oxidative phosphorylation_Homo sapiens_hsa001903.30575342
4Proteasome_Homo sapiens_hsa030503.27087968
5Allograft rejection_Homo sapiens_hsa053302.74733829
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.66249944
7Autoimmune thyroid disease_Homo sapiens_hsa053202.64097665
8Parkinsons disease_Homo sapiens_hsa050122.62290631
9Graft-versus-host disease_Homo sapiens_hsa053322.54094632
10Type I diabetes mellitus_Homo sapiens_hsa049402.47917812
11Homologous recombination_Homo sapiens_hsa034402.25575813
12Linoleic acid metabolism_Homo sapiens_hsa005912.07150090
13Protein export_Homo sapiens_hsa030602.07145068
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95280040
15One carbon pool by folate_Homo sapiens_hsa006701.83308139
16Huntingtons disease_Homo sapiens_hsa050161.80965568
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78037894
18RNA polymerase_Homo sapiens_hsa030201.76654441
19Alzheimers disease_Homo sapiens_hsa050101.70892235
20RNA degradation_Homo sapiens_hsa030181.65710564
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63105815
22Phototransduction_Homo sapiens_hsa047441.55900169
23Nucleotide excision repair_Homo sapiens_hsa034201.54119644
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.48408774
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45195601
26Fanconi anemia pathway_Homo sapiens_hsa034601.44848486
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44210410
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40354500
29Primary immunodeficiency_Homo sapiens_hsa053401.37911601
30Base excision repair_Homo sapiens_hsa034101.37274074
31Sulfur metabolism_Homo sapiens_hsa009201.36062754
32Mismatch repair_Homo sapiens_hsa034301.36040776
33Antigen processing and presentation_Homo sapiens_hsa046121.35953106
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32400254
35Fat digestion and absorption_Homo sapiens_hsa049751.26691563
36Ether lipid metabolism_Homo sapiens_hsa005651.23667747
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23497092
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22299592
39Arachidonic acid metabolism_Homo sapiens_hsa005901.22216460
40Rheumatoid arthritis_Homo sapiens_hsa053231.21818907
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16387902
42Basal transcription factors_Homo sapiens_hsa030221.14090557
43Cardiac muscle contraction_Homo sapiens_hsa042601.10958482
44Viral myocarditis_Homo sapiens_hsa054161.10729575
45Staphylococcus aureus infection_Homo sapiens_hsa051501.10644496
46Nitrogen metabolism_Homo sapiens_hsa009101.08683224
47Hematopoietic cell lineage_Homo sapiens_hsa046401.05023861
48Chemical carcinogenesis_Homo sapiens_hsa052041.02928293
49Spliceosome_Homo sapiens_hsa030400.92830690
50Pyrimidine metabolism_Homo sapiens_hsa002400.92457324
51Folate biosynthesis_Homo sapiens_hsa007900.92428410
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91837255
53Systemic lupus erythematosus_Homo sapiens_hsa053220.89680782
54RNA transport_Homo sapiens_hsa030130.87252821
55Non-homologous end-joining_Homo sapiens_hsa034500.86999002
56Purine metabolism_Homo sapiens_hsa002300.86239990
57Peroxisome_Homo sapiens_hsa041460.83089579
58Propanoate metabolism_Homo sapiens_hsa006400.81173037
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78451100
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77014239
61Retinol metabolism_Homo sapiens_hsa008300.75677667
62DNA replication_Homo sapiens_hsa030300.75006457
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71165578
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69099031
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68080580
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66679655
67Leishmaniasis_Homo sapiens_hsa051400.65190109
68Pyruvate metabolism_Homo sapiens_hsa006200.64885496
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64147600
70Tryptophan metabolism_Homo sapiens_hsa003800.62181557
71Caffeine metabolism_Homo sapiens_hsa002320.61225591
72Vitamin digestion and absorption_Homo sapiens_hsa049770.61031138
73Fatty acid elongation_Homo sapiens_hsa000620.60971784
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58527130
75Glutathione metabolism_Homo sapiens_hsa004800.56802808
76Metabolic pathways_Homo sapiens_hsa011000.56299776
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.54206037
78Butanoate metabolism_Homo sapiens_hsa006500.54143162
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51504181
80Herpes simplex infection_Homo sapiens_hsa051680.49156220
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47566646
82Selenocompound metabolism_Homo sapiens_hsa004500.46082698
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43278156
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.42789947
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42346158
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.39576964
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.39459625
88Olfactory transduction_Homo sapiens_hsa047400.35540925
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32773826
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31095587
91Fatty acid degradation_Homo sapiens_hsa000710.30321891
92Salivary secretion_Homo sapiens_hsa049700.27951057
93Epstein-Barr virus infection_Homo sapiens_hsa051690.26567176
94Sulfur relay system_Homo sapiens_hsa041220.25959226
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24559854
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24477026
97Mineral absorption_Homo sapiens_hsa049780.24325561
98Regulation of autophagy_Homo sapiens_hsa041400.24312259
99Collecting duct acid secretion_Homo sapiens_hsa049660.22862597
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.22069738

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