ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	8.28499931
2	nucleoside salvage (GO:0043174)	7.53105422
3	UMP biosynthetic process (GO:0006222)	7.31880267
4	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	7.31880267
5	UMP metabolic process (GO:0046049)	7.31880267
6	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	7.31880267
7	pyrimidine-containing compound salvage (GO:0008655)	7.17115626
8	pyrimidine nucleoside salvage (GO:0043097)	7.17115626
9	CTP biosynthetic process (GO:0006241)	6.82621997
10	CTP metabolic process (GO:0046036)	6.82621997
11	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	6.45997409
12	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	6.31962451
13	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	6.28817647
14	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	6.15992399
15	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	5.76541505
16	viral transcription (GO:0019083)	5.60199686
17	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	5.55333840
18	translational termination (GO:0006415)	5.47297075
19	ribosomal small subunit assembly (GO:0000028)	5.36826017
20	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	5.19668893
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.16390743
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.16390743
23	translational elongation (GO:0006414)	5.07324763
24	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	4.93269457
25	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.63485712
26	pyrimidine ribonucleotide metabolic process (GO:0009218)	4.58506298
27	purine nucleotide salvage (GO:0032261)	4.58175942
28	cotranslational protein targeting to membrane (GO:0006613)	4.52819370
29	protein targeting to ER (GO:0045047)	4.47206905
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.30306054
31	pyrimidine nucleotide biosynthetic process (GO:0006221)	4.26411731
32	diterpenoid biosynthetic process (GO:0016102)	4.18853706
33	protein localization to endoplasmic reticulum (GO:0070972)	4.17895171
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.17158841
35	ATP synthesis coupled proton transport (GO:0015986)	4.17158841
36	cellular protein complex disassembly (GO:0043624)	4.14264119
37	pentose metabolic process (GO:0019321)	4.07694042
38	maturation of SSU-rRNA (GO:0030490)	4.01588192
39	GTP biosynthetic process (GO:0006183)	4.00085992
40	viral life cycle (GO:0019058)	3.95533225
41	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.94627413
42	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.93657293
43	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.85575987
44	cellular metabolic compound salvage (GO:0043094)	3.83981677
45	keratinocyte development (GO:0003334)	3.82634411
46	protein complex biogenesis (GO:0070271)	3.71293619
47	translational initiation (GO:0006413)	3.68950612
48	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.68950481
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66926365
50	terpenoid biosynthetic process (GO:0016114)	3.65708735
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.62229515
52	translation (GO:0006412)	3.58343866
53	chaperone-mediated protein transport (GO:0072321)	3.57998489
54	UTP biosynthetic process (GO:0006228)	3.51675544
55	protein complex disassembly (GO:0043241)	3.51352599
56	UTP metabolic process (GO:0046051)	3.50022396
57	negative regulation of JAK-STAT cascade (GO:0046426)	3.48469509
58	pentose-phosphate shunt (GO:0006098)	3.46525107
59	pyrimidine-containing compound biosynthetic process (GO:0072528)	3.40432040
60	macromolecular complex disassembly (GO:0032984)	3.33632954
61	regulation of activation of Janus kinase activity (GO:0010533)	3.31223244
62	pyrimidine nucleotide metabolic process (GO:0006220)	3.30455087
63	tRNA modification (GO:0006400)	3.29925197
64	respiratory chain complex IV assembly (GO:0008535)	3.27914526
65	AMP metabolic process (GO:0046033)	3.27600831
66	negative regulation of B cell apoptotic process (GO:0002903)	3.21339766
67	nucleoside triphosphate biosynthetic process (GO:0009142)	3.19381807
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19213554
69	ribosomal large subunit biogenesis (GO:0042273)	3.17416619
70	neutrophil activation involved in immune response (GO:0002283)	3.11702417
71	cytochrome complex assembly (GO:0017004)	3.09321510
72	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.03242765
73	NADPH regeneration (GO:0006740)	3.02036576
74	purine-containing compound salvage (GO:0043101)	2.94160786
75	activation of NF-kappaB-inducing kinase activity (GO:0007250)	2.93365837
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90965741
77	NADH dehydrogenase complex assembly (GO:0010257)	2.90965741
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90965741
79	protein targeting to membrane (GO:0006612)	2.90284660
80	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.89357391
81	autophagic vacuole fusion (GO:0000046)	2.86550830
82	pyrimidine nucleoside metabolic process (GO:0006213)	2.86163082
83	DNA ligation (GO:0006266)	2.85897896
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.81738695
85	behavioral response to nicotine (GO:0035095)	2.79410654
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.79225742
87	electron transport chain (GO:0022900)	2.78430183
88	respiratory electron transport chain (GO:0022904)	2.78262553
89	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.77213587
90	S-adenosylmethionine metabolic process (GO:0046500)	2.76089517
91	regulation of hypersensitivity (GO:0002883)	2.75440771
92	DNA deamination (GO:0045006)	2.75390230
93	tRNA processing (GO:0008033)	2.73988589
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.73015340
95	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.70509347
96	ribonucleoside monophosphate biosynthetic process (GO:0009156)	2.69101090
97	hydrogen ion transmembrane transport (GO:1902600)	2.62912916
98	grooming behavior (GO:0007625)	2.61947088
99	response to folic acid (GO:0051593)	2.61877853
100	ribosomal small subunit biogenesis (GO:0042274)	2.61803112

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.13161292
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.07308853
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.03935954
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.86151737
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.50761896
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89954476
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73171974
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72941889
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64628427
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56255231
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40355055
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.34378654
13	VDR_22108803_ChIP-Seq_LS180_Human	2.20991897
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18226778
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16030426
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.08361015
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00015054
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93513190
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.87596666
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87154989
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84026594
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.82892997
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.79098888
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76843124
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74813132
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.71645810
27	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.68839591
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.59354850
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55129357
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54574441
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.53278428
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51015506
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.50721667
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.48046296
35	RUNX_20019798_ChIP-Seq_JUKART_Human	1.47383472
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44605621
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42817908
38	GATA3_26560356_Chip-Seq_TH2_Human	1.42814676
39	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.42655375
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.39666823
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39232012
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38979183
43	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.37917186
44	EWS_26573619_Chip-Seq_HEK293_Human	1.37334620
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.34326595
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.31949287
47	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30306445
48	NCOR_22424771_ChIP-Seq_293T_Human	1.29512984
49	AR_20517297_ChIP-Seq_VCAP_Human	1.29376526
50	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26048192
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25073179
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25073179
53	ERA_21632823_ChIP-Seq_H3396_Human	1.21916602
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20463189
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.19204063
56	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17909446
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.17889871
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15344378
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14584130
60	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.13305532
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.10653006
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.07823868
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07433552
64	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07139881
65	FUS_26573619_Chip-Seq_HEK293_Human	1.06217446
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05949380
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05736801
68	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04978611
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03307466
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02853572
71	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.02315813
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02166731
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01856316
74	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.01651379
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00414740
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99540805
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99126651
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99126651
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98714655
80	GABP_19822575_ChIP-Seq_HepG2_Human	0.98572906
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97793669
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97720202
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97531999
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95920535
85	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94484169
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94032490
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92822094
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92772885
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.92772885
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92050710
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.90680931
92	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90632840
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.88274597
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88266722
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88098245
96	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.87854881
97	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.87227009
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87099231
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86977441
100	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.86945278

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.01830199
2	MP0009379_abnormal_foot_pigmentation	3.82573819
3	MP0003806_abnormal_nucleotide_metabolis	3.28822062
4	MP0003724_increased_susceptibility_to	3.20089222
5	MP0006292_abnormal_olfactory_placode	3.07795236
6	MP0002138_abnormal_hepatobiliary_system	3.04651386
7	MP0008875_abnormal_xenobiotic_pharmacok	2.94142075
8	MP0002163_abnormal_gland_morphology	2.66911366
9	MP0006072_abnormal_retinal_apoptosis	2.54727590
10	MP0005671_abnormal_response_to	2.38498598
11	MP0004147_increased_porphyrin_level	2.33486692
12	MP0003646_muscle_fatigue	2.19109920
13	MP0008872_abnormal_physiological_respon	2.17395515
14	MP0002837_dystrophic_cardiac_calcinosis	2.14070803
15	MP0001873_stomach_inflammation	2.09863153
16	MP0000372_irregular_coat_pigmentation	1.84132032
17	MP0002148_abnormal_hypersensitivity_rea	1.78243556
18	MP0005000_abnormal_immune_tolerance	1.73167524
19	MP0001968_abnormal_touch/_nociception	1.70675610
20	MP0001800_abnormal_humoral_immune	1.66778004
21	MP0009764_decreased_sensitivity_to	1.66286468
22	MP0005084_abnormal_gallbladder_morpholo	1.62436599
23	MP0002638_abnormal_pupillary_reflex	1.59698345
24	MP0005360_urolithiasis	1.59054490
25	MP0004885_abnormal_endolymph	1.53862565
26	MP0005075_abnormal_melanosome_morpholog	1.52146712
27	MP0005646_abnormal_pituitary_gland	1.49870827
28	MP0000516_abnormal_urinary_system	1.49082108
29	MP0005367_renal/urinary_system_phenotyp	1.49082108
30	MP0000538_abnormal_urinary_bladder	1.48766741
31	MP0009785_altered_susceptibility_to	1.47358558
32	MP0002452_abnormal_antigen_presenting	1.43939453
33	MP0002723_abnormal_immune_serum	1.40278548
34	MP0005377_hearing/vestibular/ear_phenot	1.39645410
35	MP0003878_abnormal_ear_physiology	1.39645410
36	MP0005379_endocrine/exocrine_gland_phen	1.37240533
37	MP0002277_abnormal_respiratory_mucosa	1.36154312
38	MP0002736_abnormal_nociception_after	1.35713593
39	MP0001853_heart_inflammation	1.33489757
40	MP0002006_tumorigenesis	1.30642101
41	MP0010155_abnormal_intestine_physiology	1.30335933
42	MP0005332_abnormal_amino_acid	1.27483629
43	MP0002933_joint_inflammation	1.27090425
44	MP0005167_abnormal_blood-brain_barrier	1.24985116
45	MP0001986_abnormal_taste_sensitivity	1.23442261
46	MP0002234_abnormal_pharynx_morphology	1.23156563
47	MP0002166_altered_tumor_susceptibility	1.22449995
48	MP0005253_abnormal_eye_physiology	1.21980294
49	MP0001819_abnormal_immune_cell	1.21288378
50	MP0001293_anophthalmia	1.18521874
51	MP0003866_abnormal_defecation	1.17360495
52	MP0002420_abnormal_adaptive_immunity	1.14486902
53	MP0006036_abnormal_mitochondrial_physio	1.13496033
54	MP0002102_abnormal_ear_morphology	1.13150035
55	MP0003195_calcinosis	1.12123084
56	MP0003718_maternal_effect	1.11857692
57	MP0008995_early_reproductive_senescence	1.11781297
58	MP0001845_abnormal_inflammatory_respons	1.11246729
59	MP0000465_gastrointestinal_hemorrhage	1.11188051
60	MP0005551_abnormal_eye_electrophysiolog	1.10076212
61	MP0004145_abnormal_muscle_electrophysio	1.08161797
62	MP0001663_abnormal_digestive_system	1.06648456
63	MP0003786_premature_aging	1.03915414
64	MP0001790_abnormal_immune_system	1.03249934
65	MP0005387_immune_system_phenotype	1.03249934
66	MP0008877_abnormal_DNA_methylation	1.01917839
67	MP0005085_abnormal_gallbladder_physiolo	1.01232996
68	MP0006082_CNS_inflammation	0.96274321
69	MP0004142_abnormal_muscle_tone	0.96270072
70	MP0001756_abnormal_urination	0.94125061
71	MP0002095_abnormal_skin_pigmentation	0.91222184
72	MP0002272_abnormal_nervous_system	0.91041957
73	MP0005025_abnormal_response_to	0.90613357
74	MP0008058_abnormal_DNA_repair	0.89810857
75	MP0005408_hypopigmentation	0.89712416
76	MP0000383_abnormal_hair_follicle	0.89669208
77	MP0004043_abnormal_pH_regulation	0.88492085
78	MP0002733_abnormal_thermal_nociception	0.88061981
79	MP0005389_reproductive_system_phenotype	0.87958271
80	MP0005645_abnormal_hypothalamus_physiol	0.87939349
81	MP0003880_abnormal_central_pattern	0.86988843
82	MP0001970_abnormal_pain_threshold	0.86980347
83	MP0009643_abnormal_urine_homeostasis	0.86533735
84	MP0002938_white_spotting	0.86516652
85	MP0000569_abnormal_digit_pigmentation	0.86251438
86	MP0001905_abnormal_dopamine_level	0.85770955
87	MP0006276_abnormal_autonomic_nervous	0.83932643
88	MP0008873_increased_physiological_sensi	0.81983378
89	MP0000716_abnormal_immune_system	0.81899017
90	MP0010329_abnormal_lipoprotein_level	0.81645109
91	MP0001919_abnormal_reproductive_system	0.80361986
92	MP0003567_abnormal_fetal_cardiomyocyte	0.79929084
93	MP0000613_abnormal_salivary_gland	0.78794086
94	MP0000689_abnormal_spleen_morphology	0.78518502
95	MP0000685_abnormal_immune_system	0.77438214
96	MP0000467_abnormal_esophagus_morphology	0.76929877
97	MP0005636_abnormal_mineral_homeostasis	0.72987666
98	MP0001346_abnormal_lacrimal_gland	0.72690914
99	MP0002398_abnormal_bone_marrow	0.72208192
100	MP0009745_abnormal_behavioral_response	0.71978711

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.36258205
2	Hypoplasia of the pons (HP:0012110)	4.24067590
3	Opisthotonus (HP:0002179)	4.21434336
4	Congenital, generalized hypertrichosis (HP:0004540)	4.04865905
5	Abnormality of the pons (HP:0007361)	4.03503780
6	Acute necrotizing encephalopathy (HP:0006965)	3.95918740
7	Mitochondrial inheritance (HP:0001427)	3.90469991
8	Lipid accumulation in hepatocytes (HP:0006561)	3.81344127
9	Hip dysplasia (HP:0001385)	3.73367388
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.50109092
11	Absent/shortened dynein arms (HP:0200106)	3.50109092
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.49779072
13	Renal Fanconi syndrome (HP:0001994)	3.43468848
14	Increased CSF lactate (HP:0002490)	3.40672353
15	Difficulty running (HP:0009046)	3.39870910
16	Progressive macrocephaly (HP:0004481)	3.36090895
17	Exertional dyspnea (HP:0002875)	3.30633731
18	Acute encephalopathy (HP:0006846)	3.28505134
19	Pancreatic fibrosis (HP:0100732)	3.18428517
20	Polydipsia (HP:0001959)	3.16171877
21	Abnormal drinking behavior (HP:0030082)	3.16171877
22	Bile duct proliferation (HP:0001408)	3.14629334
23	Abnormal biliary tract physiology (HP:0012439)	3.14629334
24	Pancreatic cysts (HP:0001737)	3.14409755
25	Increased intramyocellular lipid droplets (HP:0012240)	3.04881614
26	Hepatocellular necrosis (HP:0001404)	2.98245846
27	Congenital stationary night blindness (HP:0007642)	2.96891712
28	Abnormality of the prostate (HP:0008775)	2.76673798
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.73071008
30	Hepatic necrosis (HP:0002605)	2.65586630
31	Hip contracture (HP:0003273)	2.63120719
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.62624864
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.60148659
34	Elevated erythrocyte sedimentation rate (HP:0003565)	2.59327106
35	Aplastic anemia (HP:0001915)	2.57889345
36	Progressive microcephaly (HP:0000253)	2.56510966
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.49760334
38	Abnormal number of erythroid precursors (HP:0012131)	2.45802838
39	Polyuria (HP:0000103)	2.41174202
40	Increased muscle lipid content (HP:0009058)	2.39282624
41	Molar tooth sign on MRI (HP:0002419)	2.38894724
42	Abnormality of midbrain morphology (HP:0002418)	2.38894724
43	True hermaphroditism (HP:0010459)	2.37228910
44	Cerebral palsy (HP:0100021)	2.34794542
45	Cerebral edema (HP:0002181)	2.33992558
46	Poor suck (HP:0002033)	2.30037602
47	Stomatitis (HP:0010280)	2.28436025
48	Supernumerary spleens (HP:0009799)	2.26521474
49	Reticulocytopenia (HP:0001896)	2.25165624
50	Abnormal ciliary motility (HP:0012262)	2.23767161
51	Achilles tendon contracture (HP:0001771)	2.23562048
52	Abnormality of secondary sexual hair (HP:0009888)	2.23134626
53	Abnormality of the axillary hair (HP:0100134)	2.23134626
54	Dry hair (HP:0011359)	2.19153252
55	Abnormality of the renal cortex (HP:0011035)	2.19122391
56	Hyperglycinemia (HP:0002154)	2.18838427
57	Asplenia (HP:0001746)	2.16633608
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15902396
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.15902396
60	Glycosuria (HP:0003076)	2.15671822
61	Abnormality of urine glucose concentration (HP:0011016)	2.15671822
62	Tubular atrophy (HP:0000092)	2.15348088
63	Cystic liver disease (HP:0006706)	2.14514039
64	Lactic acidosis (HP:0003128)	2.14455561
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.12944647
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.12944647
67	Parakeratosis (HP:0001036)	2.11077955
68	Severe global developmental delay (HP:0011344)	2.10532153
69	Type II lissencephaly (HP:0007260)	2.10219576
70	Obstructive lung disease (HP:0006536)	2.08952857
71	Chronic obstructive pulmonary disease (HP:0006510)	2.08952857
72	Macrocytic anemia (HP:0001972)	2.08814136
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07824048
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07510419
75	Hyperphosphaturia (HP:0003109)	2.04331323
76	Abnormality of the anterior horn cell (HP:0006802)	2.03731923
77	Degeneration of anterior horn cells (HP:0002398)	2.03731923
78	Respiratory difficulties (HP:0002880)	2.03502756
79	Dyskinesia (HP:0100660)	2.02949738
80	Type 2 muscle fiber atrophy (HP:0003554)	2.02098944
81	Abnormal urine output (HP:0012590)	1.99941062
82	Facial shape deformation (HP:0011334)	1.98436127
83	Potter facies (HP:0002009)	1.98436127
84	Abnormality of the renal medulla (HP:0100957)	1.97334897
85	IgG deficiency (HP:0004315)	1.96784230
86	Abnormality of the Achilles tendon (HP:0005109)	1.96753007
87	Abnormality of renal resorption (HP:0011038)	1.94117297
88	Autoimmune thrombocytopenia (HP:0001973)	1.92293974
89	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.91380186
90	Optic disc pallor (HP:0000543)	1.89385530
91	Tubulointerstitial fibrosis (HP:0005576)	1.88246268
92	Poor speech (HP:0002465)	1.86556969
93	Limited hip movement (HP:0008800)	1.84731824
94	Respiratory failure (HP:0002878)	1.82805171
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81740566
96	Increased serum lactate (HP:0002151)	1.81669611
97	Fair hair (HP:0002286)	1.81084982
98	Woolly hair (HP:0002224)	1.80646647
99	3-Methylglutaconic aciduria (HP:0003535)	1.80442052
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.79279629

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.34559763
2	LIMK1	3.10603747
3	BCKDK	2.81806572
4	ZAK	2.67330353
5	CDK19	2.62445947
6	TAOK3	2.55390366
7	NUAK1	2.44696446
8	ADRBK2	2.35146776
9	WNK4	2.32385052
10	GRK1	2.12857892
11	KIT	1.92889513
12	STK16	1.91837944
13	OXSR1	1.91751164
14	MAP4K1	1.91066290
15	FRK	1.86013685
16	TXK	1.81720905
17	BMPR2	1.77512275
18	NME2	1.70796150
19	MAP3K14	1.69672653
20	BMPR1B	1.57737592
21	EIF2AK1	1.51925983
22	BUB1	1.51046095
23	VRK2	1.41273791
24	MYLK	1.41200346
25	CSF1R	1.39860354
26	STK39	1.38879478
27	INSRR	1.27711651
28	WNK3	1.27346854
29	IKBKB	1.27018633
30	DYRK2	1.25318780
31	KDR	1.16012693
32	MAP4K2	1.15268762
33	FES	1.14436166
34	RPS6KA5	1.10450609
35	VRK1	1.10318742
36	IKBKE	1.07995841
37	NLK	1.07568923
38	ITK	1.06927045
39	PLK2	1.01832655
40	MST4	1.00730327
41	NME1	0.99936562
42	LCK	0.98073371
43	MATK	0.98028718
44	SYK	0.96907133
45	LYN	0.95570875
46	TEC	0.94310159
47	PKN1	0.93926641
48	PRKCQ	0.86999976
49	PINK1	0.86978357
50	CSNK2A2	0.84588583
51	CSNK1G1	0.84186647
52	TRIM28	0.83688752
53	OBSCN	0.81368056
54	BTK	0.80999968
55	PRKCG	0.78316352
56	PHKG1	0.76769733
57	PHKG2	0.76769733
58	GRK6	0.73552938
59	CSNK2A1	0.73422458
60	CAMKK2	0.72984292
61	ADRBK1	0.72547327
62	GRK5	0.70397159
63	TIE1	0.68400604
64	MAP2K2	0.68138843
65	FLT3	0.67432383
66	MAP3K12	0.67266002
67	MAP2K6	0.67146911
68	DAPK1	0.66486400
69	EIF2AK3	0.65412691
70	TESK1	0.65343880
71	PLK3	0.62922882
72	IGF1R	0.62393829
73	ABL2	0.60794605
74	JAK3	0.59947272
75	PTK2B	0.57848651
76	ACVR1B	0.57534845
77	CSNK1A1	0.57236763
78	EPHA3	0.56022234
79	ABL1	0.53750802
80	PRKCA	0.53513248
81	CAMK1	0.53210569
82	CAMK1D	0.53182362
83	MUSK	0.52432215
84	AURKB	0.52421392
85	NEK1	0.49756079
86	PLK1	0.49667619
87	WNK1	0.49609189
88	DAPK2	0.49091105
89	CDK8	0.48366019
90	RIPK4	0.47254996
91	DAPK3	0.45541643
92	MAPK15	0.45143902
93	TNK2	0.44090744
94	LRRK2	0.42739413
95	EIF2AK2	0.41760118
96	TGFBR1	0.40478931
97	GRK7	0.40431519
98	PLK4	0.40021706
99	EGFR	0.38869612
100	PRKCE	0.38366870

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.84731409
2	Ribosome_Homo sapiens_hsa03010	4.16523955
3	Allograft rejection_Homo sapiens_hsa05330	3.81066258
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.66567776
5	Sulfur relay system_Homo sapiens_hsa04122	3.52086684
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.41742260
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.28715823
8	Type I diabetes mellitus_Homo sapiens_hsa04940	3.08565705
9	Proteasome_Homo sapiens_hsa03050	2.61909067
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52832544
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.21511820
12	Parkinsons disease_Homo sapiens_hsa05012	2.00772415
13	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.83968592
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.82905917
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.81059151
16	Viral myocarditis_Homo sapiens_hsa05416	1.73816769
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73519014
18	RNA polymerase_Homo sapiens_hsa03020	1.69218207
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.60241683
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.57535148
21	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.57145100
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.39898571
23	Alzheimers disease_Homo sapiens_hsa05010	1.36068921
24	Leishmaniasis_Homo sapiens_hsa05140	1.28557730
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21827998
26	Huntingtons disease_Homo sapiens_hsa05016	1.20712555
27	Protein export_Homo sapiens_hsa03060	1.20637079
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.18305460
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.12348161
30	DNA replication_Homo sapiens_hsa03030	1.11944805
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10983448
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.02929112
33	Pentose phosphate pathway_Homo sapiens_hsa00030	1.00799233
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00382884
35	RNA degradation_Homo sapiens_hsa03018	0.99429064
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98002679
37	Primary immunodeficiency_Homo sapiens_hsa05340	0.97945503
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97725268
39	Homologous recombination_Homo sapiens_hsa03440	0.91303475
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90417866
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.90001888
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.89650350
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89057993
44	Phototransduction_Homo sapiens_hsa04744	0.88769914
45	Peroxisome_Homo sapiens_hsa04146	0.82347330
46	One carbon pool by folate_Homo sapiens_hsa00670	0.80267984
47	Propanoate metabolism_Homo sapiens_hsa00640	0.79379478
48	Mismatch repair_Homo sapiens_hsa03430	0.78646316
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77645876
50	Butanoate metabolism_Homo sapiens_hsa00650	0.74504443
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74270558
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72673894
53	Purine metabolism_Homo sapiens_hsa00230	0.72059913
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.66664461
55	Caffeine metabolism_Homo sapiens_hsa00232	0.66359896
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63614281
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62905374
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59647858
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57541684
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57374099
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57262370
62	Sulfur metabolism_Homo sapiens_hsa00920	0.55502509
63	Regulation of autophagy_Homo sapiens_hsa04140	0.55379395
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55094838
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51374405
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.49446631
67	Metabolic pathways_Homo sapiens_hsa01100	0.49116607
68	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.47606559
69	Influenza A_Homo sapiens_hsa05164	0.47135984
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45948527
71	Olfactory transduction_Homo sapiens_hsa04740	0.45732327
72	Basal transcription factors_Homo sapiens_hsa03022	0.44269933
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43994841
74	Phagosome_Homo sapiens_hsa04145	0.43982382
75	RNA transport_Homo sapiens_hsa03013	0.41884500
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41355206
77	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40183269
78	Herpes simplex infection_Homo sapiens_hsa05168	0.39402594
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38008149
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.38001056
81	Base excision repair_Homo sapiens_hsa03410	0.37542563
82	Measles_Homo sapiens_hsa05162	0.37128487
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35382413
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34183036
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33317318
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31462544
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31279184
88	Spliceosome_Homo sapiens_hsa03040	0.31063199
89	Retinol metabolism_Homo sapiens_hsa00830	0.31058957
90	Toxoplasmosis_Homo sapiens_hsa05145	0.30595247
91	Glutathione metabolism_Homo sapiens_hsa00480	0.30497864
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29917187
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.29465201
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27996716
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26902549
96	Tuberculosis_Homo sapiens_hsa05152	0.26715987
97	Legionellosis_Homo sapiens_hsa05134	0.24315149
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.23423472
99	Nicotine addiction_Homo sapiens_hsa05033	0.23257434
100	Fatty acid degradation_Homo sapiens_hsa00071	0.22327154

RPS10P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »