ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.16919013
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.12535165
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.92349717
4	ATP synthesis coupled proton transport (GO:0015986)	4.92349717
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.88005469
6	positive regulation of guanylate cyclase activity (GO:0031284)	4.46742536
7	protein complex biogenesis (GO:0070271)	4.43087493
8	ribosomal small subunit assembly (GO:0000028)	4.40681060
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.28339091
10	mitochondrial respiratory chain complex assembly (GO:0033108)	4.08871170
11	rRNA catabolic process (GO:0016075)	4.05188738
12	regulation of guanylate cyclase activity (GO:0031282)	3.97525057
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.96238166
14	NADH dehydrogenase complex assembly (GO:0010257)	3.96238166
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.96238166
16	positive regulation of prostaglandin secretion (GO:0032308)	3.96161772
17	respiratory electron transport chain (GO:0022904)	3.95427868
18	electron transport chain (GO:0022900)	3.91996113
19	DNA deamination (GO:0045006)	3.78105154
20	chaperone-mediated protein transport (GO:0072321)	3.77394314
21	maturation of SSU-rRNA (GO:0030490)	3.75231984
22	base-excision repair, AP site formation (GO:0006285)	3.67988007
23	axonemal dynein complex assembly (GO:0070286)	3.58250485
24	viral transcription (GO:0019083)	3.57653790
25	aldehyde catabolic process (GO:0046185)	3.57092194
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53819191
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53819191
28	DNA damage response, detection of DNA damage (GO:0042769)	3.52752795
29	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.51994337
30	ribosomal small subunit biogenesis (GO:0042274)	3.51537603
31	termination of RNA polymerase III transcription (GO:0006386)	3.50828050
32	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.50828050
33	behavioral response to nicotine (GO:0035095)	3.49577280
34	positive regulation of cGMP biosynthetic process (GO:0030828)	3.47870616
35	translational termination (GO:0006415)	3.46034161
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.45416125
37	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.42363638
38	cotranslational protein targeting to membrane (GO:0006613)	3.37226392
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.34326716
40	protein targeting to ER (GO:0045047)	3.32837306
41	respiratory chain complex IV assembly (GO:0008535)	3.31598043
42	amino acid salvage (GO:0043102)	3.24613135
43	L-methionine salvage (GO:0071267)	3.24613135
44	L-methionine biosynthetic process (GO:0071265)	3.24613135
45	regulation of cGMP biosynthetic process (GO:0030826)	3.21989677
46	protein localization to endoplasmic reticulum (GO:0070972)	3.18563741
47	ubiquinone biosynthetic process (GO:0006744)	3.17555870
48	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.15749795
49	protein neddylation (GO:0045116)	3.15528941
50	regulation of cGMP metabolic process (GO:0030823)	3.15154523
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.15100235
52	regulation of cellular amino acid metabolic process (GO:0006521)	3.13844514
53	proteasome assembly (GO:0043248)	3.10899265
54	cytidine metabolic process (GO:0046087)	3.10225326
55	cytidine catabolic process (GO:0006216)	3.10225326
56	cytidine deamination (GO:0009972)	3.10225326
57	rhodopsin mediated signaling pathway (GO:0016056)	3.08128927
58	pyrimidine nucleotide catabolic process (GO:0006244)	3.07180865
59	cytochrome complex assembly (GO:0017004)	3.06593840
60	positive regulation of cGMP metabolic process (GO:0030825)	3.05834472
61	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.04968915
62	translation (GO:0006412)	3.03686620
63	regulation of prostaglandin secretion (GO:0032306)	3.01657723
64	metallo-sulfur cluster assembly (GO:0031163)	3.00588592
65	iron-sulfur cluster assembly (GO:0016226)	3.00588592
66	translational elongation (GO:0006414)	2.98154693
67	cellular component biogenesis (GO:0044085)	2.97847324
68	protein-cofactor linkage (GO:0018065)	2.96934305
69	ubiquinone metabolic process (GO:0006743)	2.95169791
70	proton transport (GO:0015992)	2.94926592
71	hydrogen ion transmembrane transport (GO:1902600)	2.94362314
72	pseudouridine synthesis (GO:0001522)	2.92308111
73	GTP biosynthetic process (GO:0006183)	2.92274426
74	positive regulation of fatty acid transport (GO:2000193)	2.91255347
75	mast cell activation involved in immune response (GO:0002279)	2.91102656
76	mast cell degranulation (GO:0043303)	2.91102656
77	intracellular protein transmembrane import (GO:0044743)	2.89902428
78	cullin deneddylation (GO:0010388)	2.89114860
79	peptidyl-histidine modification (GO:0018202)	2.87713667
80	hydrogen transport (GO:0006818)	2.87107101
81	methionine biosynthetic process (GO:0009086)	2.84112478
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.84089802
83	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83832540
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81610953
85	ATP biosynthetic process (GO:0006754)	2.81505184
86	auditory receptor cell differentiation (GO:0042491)	2.80454008
87	ribosomal large subunit biogenesis (GO:0042273)	2.78999397
88	rRNA modification (GO:0000154)	2.77586776
89	protein prenylation (GO:0018342)	2.76578382
90	prenylation (GO:0097354)	2.76578382
91	positive regulation of icosanoid secretion (GO:0032305)	2.75275098
92	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.74267908
93	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.74267908
94	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.74267908
95	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.74209488
96	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74070102
97	translational initiation (GO:0006413)	2.71853483
98	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71452679
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71452679
100	methionine metabolic process (GO:0006555)	2.70310533

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.81524727
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08483815
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84414999
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.31078435
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08943933
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.99834279
7	VDR_22108803_ChIP-Seq_LS180_Human	2.94681671
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70637052
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57584239
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53528263
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.40461718
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34622210
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.19954741
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.14683448
15	FUS_26573619_Chip-Seq_HEK293_Human	2.07145226
16	EWS_26573619_Chip-Seq_HEK293_Human	2.02057195
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00308965
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.99902908
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98825215
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.92788546
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.87681351
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75777498
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.75479851
24	P300_19829295_ChIP-Seq_ESCs_Human	1.73039821
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.72192331
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70687830
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69533284
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66952385
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64264436
30	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.62944143
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55686394
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.55585539
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.53868881
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53868881
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52441246
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51432955
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48610781
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48583958
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48550001
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48449667
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.45815331
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45594534
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44836997
44	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.44630986
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41206944
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41206944
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.39596487
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37476153
49	PHF8_20622853_ChIP-Seq_HELA_Human	1.33572973
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32437369
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32437369
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31651730
53	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31114856
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27794390
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26595074
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23861251
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23472073
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.22027599
59	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.21568328
60	NCOR_22424771_ChIP-Seq_293T_Human	1.21022670
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20622213
62	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19059956
63	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.18708223
64	AR_20517297_ChIP-Seq_VCAP_Human	1.18662461
65	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18190555
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.17513150
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.16993901
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16843933
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15441676
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14837372
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12991897
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12722225
73	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10083449
74	NFYB_21822215_ChIP-Seq_K562_Human	1.09377089
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06879731
76	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06463402
77	ETV1_20927104_ChIP-Seq_GIST48_Human	1.05046574
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04216252
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04158610
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.03306321
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03109241
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98373040
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97923223
84	TBL1_22424771_ChIP-Seq_293T_Human	0.95849881
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95469290
86	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93363242
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93353918
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92925354
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92753821
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92352285
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.92098312
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.89968816
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89968816
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89833347
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89319386
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.89254029
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89244869
98	AR_25329375_ChIP-Seq_VCAP_Human	0.88928084
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88282104
100	NFYA_21822215_ChIP-Seq_K562_Human	0.87644725

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.02455131
2	MP0003195_calcinosis	3.88982713
3	MP0005084_abnormal_gallbladder_morpholo	3.88453626
4	MP0000372_irregular_coat_pigmentation	3.88015002
5	MP0003880_abnormal_central_pattern	3.36537991
6	MP0002139_abnormal_hepatobiliary_system	3.32152829
7	MP0002102_abnormal_ear_morphology	2.79014573
8	MP0003252_abnormal_bile_duct	2.73975325
9	MP0003283_abnormal_digestive_organ	2.71533165
10	MP0008877_abnormal_DNA_methylation	2.54922831
11	MP0002638_abnormal_pupillary_reflex	2.25947691
12	MP0010386_abnormal_urinary_bladder	2.21092625
13	MP0006292_abnormal_olfactory_placode	2.16716827
14	MP0006276_abnormal_autonomic_nervous	2.02294380
15	MP0004147_increased_porphyrin_level	1.93898756
16	MP0009379_abnormal_foot_pigmentation	1.73511008
17	MP0004133_heterotaxia	1.69189488
18	MP0002837_dystrophic_cardiac_calcinosis	1.67990678
19	MP0008872_abnormal_physiological_respon	1.67028399
20	MP0005551_abnormal_eye_electrophysiolog	1.57965631
21	MP0003136_yellow_coat_color	1.56072967
22	MP0001986_abnormal_taste_sensitivity	1.54799199
23	MP0002735_abnormal_chemical_nociception	1.47579301
24	MP0005377_hearing/vestibular/ear_phenot	1.44336761
25	MP0003878_abnormal_ear_physiology	1.44336761
26	MP0001968_abnormal_touch/_nociception	1.42967382
27	MP0002938_white_spotting	1.39458600
28	MP0005085_abnormal_gallbladder_physiolo	1.35913233
29	MP0005332_abnormal_amino_acid	1.34849816
30	MP0002928_abnormal_bile_duct	1.33507431
31	MP0006072_abnormal_retinal_apoptosis	1.30093294
32	MP0005075_abnormal_melanosome_morpholog	1.28676453
33	MP0002272_abnormal_nervous_system	1.26104976
34	MP0001485_abnormal_pinna_reflex	1.25366950
35	MP0001188_hyperpigmentation	1.22497629
36	MP0006036_abnormal_mitochondrial_physio	1.21209959
37	MP0002160_abnormal_reproductive_system	1.20784916
38	MP0001905_abnormal_dopamine_level	1.19012138
39	MP0003806_abnormal_nucleotide_metabolis	1.18238112
40	MP0001293_anophthalmia	1.17357567
41	MP0002234_abnormal_pharynx_morphology	1.15406526
42	MP0009745_abnormal_behavioral_response	1.13619785
43	MP0008995_early_reproductive_senescence	1.13009829
44	MP0002277_abnormal_respiratory_mucosa	1.12708344
45	MP0002822_catalepsy	1.11064957
46	MP0003786_premature_aging	1.09136953
47	MP0002736_abnormal_nociception_after	1.07291967
48	MP0008875_abnormal_xenobiotic_pharmacok	1.07088300
49	MP0005360_urolithiasis	1.06942843
50	MP0005379_endocrine/exocrine_gland_phen	1.06553003
51	MP0002163_abnormal_gland_morphology	1.05972112
52	MP0005645_abnormal_hypothalamus_physiol	1.04892713
53	MP0001970_abnormal_pain_threshold	1.04778349
54	MP0003718_maternal_effect	1.03054932
55	MP0008058_abnormal_DNA_repair	0.99649313
56	MP0003567_abnormal_fetal_cardiomyocyte	0.96141148
57	MP0003646_muscle_fatigue	0.95818373
58	MP0005220_abnormal_exocrine_pancreas	0.94435923
59	MP0002557_abnormal_social/conspecific_i	0.92379239
60	MP0000647_abnormal_sebaceous_gland	0.92034175
61	MP0009046_muscle_twitch	0.91339306
62	MP0005174_abnormal_tail_pigmentation	0.91264507
63	MP0003122_maternal_imprinting	0.90865550
64	MP0005187_abnormal_penis_morphology	0.90346968
65	MP0003121_genomic_imprinting	0.89863493
66	MP0004885_abnormal_endolymph	0.89032866
67	MP0005389_reproductive_system_phenotype	0.88474789
68	MP0001529_abnormal_vocalization	0.82463429
69	MP0005253_abnormal_eye_physiology	0.82451467
70	MP0004742_abnormal_vestibular_system	0.81405299
71	MP0003186_abnormal_redox_activity	0.80222065
72	MP0005646_abnormal_pituitary_gland	0.79459707
73	MP0001727_abnormal_embryo_implantation	0.79409730
74	MP0004142_abnormal_muscle_tone	0.79399366
75	MP0002233_abnormal_nose_morphology	0.78904852
76	MP0000026_abnormal_inner_ear	0.78652943
77	MP0003183_abnormal_peptide_metabolism	0.78139865
78	MP0003937_abnormal_limbs/digits/tail_de	0.78101220
79	MP0000049_abnormal_middle_ear	0.77688202
80	MP0002184_abnormal_innervation	0.77028449
81	MP0001963_abnormal_hearing_physiology	0.76911735
82	MP0005195_abnormal_posterior_eye	0.76676098
83	MP0005671_abnormal_response_to	0.76170628
84	MP0001440_abnormal_grooming_behavior	0.75679528
85	MP0001502_abnormal_circadian_rhythm	0.74502012
86	MP0002733_abnormal_thermal_nociception	0.74326384
87	MP0003959_abnormal_lean_body	0.73638626
88	MP0001664_abnormal_digestion	0.73237024
89	MP0002095_abnormal_skin_pigmentation	0.73086387
90	MP0002876_abnormal_thyroid_physiology	0.72643567
91	MP0002752_abnormal_somatic_nervous	0.71838882
92	MP0003787_abnormal_imprinting	0.71072042
93	MP0001286_abnormal_eye_development	0.70575563
94	MP0004957_abnormal_blastocyst_morpholog	0.70096371
95	MP0004381_abnormal_hair_follicle	0.70066159
96	MP0001501_abnormal_sleep_pattern	0.66329948
97	MP0009250_abnormal_appendicular_skeleto	0.66303023
98	MP0000631_abnormal_neuroendocrine_gland	0.65926593
99	MP0000778_abnormal_nervous_system	0.65694111
100	MP0001486_abnormal_startle_reflex	0.65262939

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.92527353
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35869059
3	Acute encephalopathy (HP:0006846)	4.16547357
4	Progressive macrocephaly (HP:0004481)	4.12317418
5	Mitochondrial inheritance (HP:0001427)	4.09146980
6	Increased CSF lactate (HP:0002490)	3.91891209
7	Methylmalonic acidemia (HP:0002912)	3.71544654
8	Increased hepatocellular lipid droplets (HP:0006565)	3.35698819
9	Cerebral edema (HP:0002181)	3.23257294
10	Hepatocellular necrosis (HP:0001404)	3.22376133
11	Gonadotropin excess (HP:0000837)	3.17935681
12	Pancreatic fibrosis (HP:0100732)	3.16124675
13	Methylmalonic aciduria (HP:0012120)	3.09794899
14	Abnormality of midbrain morphology (HP:0002418)	2.99691855
15	Molar tooth sign on MRI (HP:0002419)	2.99691855
16	Pancreatic cysts (HP:0001737)	2.94950412
17	True hermaphroditism (HP:0010459)	2.94716760
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.94630263
19	Renal Fanconi syndrome (HP:0001994)	2.93895737
20	Lipid accumulation in hepatocytes (HP:0006561)	2.92331676
21	Hepatic necrosis (HP:0002605)	2.86338728
22	Congenital stationary night blindness (HP:0007642)	2.77931731
23	Type II lissencephaly (HP:0007260)	2.67266952
24	3-Methylglutaconic aciduria (HP:0003535)	2.66435148
25	Aplastic anemia (HP:0001915)	2.64692893
26	Increased serum lactate (HP:0002151)	2.60959996
27	Reticulocytopenia (HP:0001896)	2.60395570
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.59766773
29	Abolished electroretinogram (ERG) (HP:0000550)	2.59464956
30	Increased intramyocellular lipid droplets (HP:0012240)	2.59100846
31	Abnormal respiratory motile cilium physiology (HP:0012261)	2.55415738
32	Pendular nystagmus (HP:0012043)	2.52818265
33	Nephronophthisis (HP:0000090)	2.49676372
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.48264716
35	Abnormality of alanine metabolism (HP:0010916)	2.48264716
36	Hyperalaninemia (HP:0003348)	2.48264716
37	Glycosuria (HP:0003076)	2.47048487
38	Abnormality of urine glucose concentration (HP:0011016)	2.47048487
39	Lactic acidosis (HP:0003128)	2.44276020
40	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.43964312
41	Optic disc pallor (HP:0000543)	2.43565851
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.42106773
43	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.35324373
44	Abnormal biliary tract physiology (HP:0012439)	2.35165408
45	Bile duct proliferation (HP:0001408)	2.35165408
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35045410
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35045410
48	Hyperglycinemia (HP:0002154)	2.34271070
49	Abnormal ciliary motility (HP:0012262)	2.34013255
50	Hypoplasia of the uterus (HP:0000013)	2.33160775
51	Abnormality of vitamin B metabolism (HP:0004340)	2.32528160
52	Medial flaring of the eyebrow (HP:0010747)	2.27189221
53	Pancytopenia (HP:0001876)	2.27123096
54	Leukodystrophy (HP:0002415)	2.26709783
55	Macrocytic anemia (HP:0001972)	2.25480587
56	Stenosis of the external auditory canal (HP:0000402)	2.22448296
57	Male pseudohermaphroditism (HP:0000037)	2.13974683
58	Lethargy (HP:0001254)	2.13183630
59	X-linked dominant inheritance (HP:0001423)	2.12781051
60	B lymphocytopenia (HP:0010976)	2.12316874
61	Exercise intolerance (HP:0003546)	2.09923721
62	Abnormal pancreas size (HP:0012094)	2.09302108
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.07381113
64	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06217911
65	Sclerocornea (HP:0000647)	2.04932076
66	Respiratory failure (HP:0002878)	2.04556027
67	Exertional dyspnea (HP:0002875)	2.01057534
68	Carpal bone hypoplasia (HP:0001498)	2.00267393
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99988773
70	Pallor (HP:0000980)	1.99875596
71	Abnormality of renal resorption (HP:0011038)	1.99275158
72	Type I transferrin isoform profile (HP:0003642)	1.99190655
73	Abnormality of the renal medulla (HP:0100957)	1.99143170
74	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99055050
75	Decreased central vision (HP:0007663)	1.98010710
76	Renal cortical cysts (HP:0000803)	1.94332514
77	Abnormality of B cell number (HP:0010975)	1.93527776
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91226095
79	Abnormal number of erythroid precursors (HP:0012131)	1.90112719
80	Cerebral hypomyelination (HP:0006808)	1.89808374
81	Gout (HP:0001997)	1.89753965
82	Increased muscle lipid content (HP:0009058)	1.88701551
83	Abnormality of serum amino acid levels (HP:0003112)	1.88174707
84	Abnormality of male internal genitalia (HP:0000022)	1.86432838
85	Keratoconus (HP:0000563)	1.86157594
86	Increased corneal curvature (HP:0100692)	1.86157594
87	Congenital, generalized hypertrichosis (HP:0004540)	1.85024943
88	Hypophosphatemic rickets (HP:0004912)	1.81700335
89	Chronic bronchitis (HP:0004469)	1.80259652
90	Septo-optic dysplasia (HP:0100842)	1.78428266
91	Gait imbalance (HP:0002141)	1.77382547
92	Congenital primary aphakia (HP:0007707)	1.75630115
93	Absent thumb (HP:0009777)	1.70525268
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.70029685
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.70029685
96	Anencephaly (HP:0002323)	1.67766067
97	Rhinitis (HP:0012384)	1.67266603
98	Tubulointerstitial nephritis (HP:0001970)	1.66633884
99	Abnormality of the ileum (HP:0001549)	1.66528809
100	Hyperphosphaturia (HP:0003109)	1.65227053

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.25906615
2	CDK19	3.24113615
3	WNK3	3.20034771
4	BCKDK	2.81537682
5	STK16	2.79477052
6	MST4	2.58243601
7	NUAK1	2.49598279
8	MAP3K12	2.35192611
9	ZAK	2.10400075
10	TXK	2.09764937
11	GRK1	2.07929815
12	NEK1	2.02528844
13	MAP4K2	1.95048954
14	TLK1	1.92293167
15	DYRK2	1.88667693
16	VRK2	1.88251927
17	EIF2AK3	1.87096135
18	ADRBK2	1.74670696
19	CASK	1.71272574
20	WEE1	1.68467154
21	MAP3K4	1.59254697
22	WNK4	1.55051727
23	OXSR1	1.49411704
24	TIE1	1.48713597
25	MUSK	1.45310467
26	FRK	1.44503916
27	PINK1	1.37642862
28	BMPR2	1.35229528
29	KDR	1.26550471
30	MYLK	1.21005130
31	NME1	1.20533509
32	PLK2	1.20447107
33	TAF1	1.20004270
34	INSRR	1.18976561
35	BRSK2	1.16985177
36	BMPR1B	1.16959105
37	VRK1	1.13343731
38	CSNK1G2	1.12842826
39	BCR	1.11773684
40	DAPK1	1.09971540
41	CSNK1G3	1.09967010
42	MKNK2	1.04108738
43	MAP2K7	1.01933924
44	PLK3	0.99097868
45	PASK	0.98455093
46	CSNK1G1	0.98217494
47	CCNB1	0.96256186
48	PRKCQ	0.90216843
49	STK39	0.90096494
50	DAPK3	0.89067818
51	SIK3	0.86669060
52	PLK1	0.83259682
53	NME2	0.83108879
54	EIF2AK1	0.82003883
55	PRKCE	0.78038199
56	PIK3CA	0.77900636
57	CDC7	0.77378450
58	MAPK13	0.77337931
59	PRKCG	0.76864524
60	TAOK3	0.71125129
61	GRK6	0.69477137
62	MKNK1	0.68979268
63	PLK4	0.68761620
64	ERBB3	0.68020098
65	PKN1	0.66665130
66	TEC	0.65563891
67	SRPK1	0.61960286
68	PBK	0.61477877
69	ACVR1B	0.59866157
70	BUB1	0.54757469
71	CSNK1A1L	0.54620062
72	AURKB	0.52607387
73	CSNK2A2	0.49183803
74	CSNK2A1	0.48462745
75	AURKA	0.47037297
76	ADRBK1	0.46837875
77	EPHB2	0.45343546
78	BRAF	0.45258971
79	DAPK2	0.45105301
80	GRK5	0.44495979
81	PRKCH	0.42640213
82	ATR	0.41139639
83	PRKCA	0.40875330
84	PNCK	0.40826587
85	PRKACA	0.40302608
86	TNIK	0.38915688
87	CAMK2A	0.38346890
88	OBSCN	0.37675464
89	MAP3K11	0.37098961
90	PAK3	0.34571393
91	STK38L	0.33739696
92	PRKG1	0.32743121
93	CAMK1	0.31971425
94	CHEK2	0.31833354
95	RPS6KA5	0.30681417
96	LRRK2	0.30579847
97	MAPKAPK5	0.30575986
98	IKBKB	0.29999927
99	MARK3	0.29710760
100	MINK1	0.28228377

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.07765607
2	Ribosome_Homo sapiens_hsa03010	3.91299122
3	Proteasome_Homo sapiens_hsa03050	3.76995116
4	Parkinsons disease_Homo sapiens_hsa05012	3.44505064
5	Phototransduction_Homo sapiens_hsa04744	3.20193309
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.19047359
7	RNA polymerase_Homo sapiens_hsa03020	2.90694018
8	Protein export_Homo sapiens_hsa03060	2.86177888
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.40563431
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.22889861
11	Huntingtons disease_Homo sapiens_hsa05016	2.18112425
12	Alzheimers disease_Homo sapiens_hsa05010	2.16552741
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.05311738
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.96933353
15	Asthma_Homo sapiens_hsa05310	1.87201091
16	Homologous recombination_Homo sapiens_hsa03440	1.82332695
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77161031
18	RNA degradation_Homo sapiens_hsa03018	1.59444803
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51400686
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39595607
21	Propanoate metabolism_Homo sapiens_hsa00640	1.32148495
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30276396
23	One carbon pool by folate_Homo sapiens_hsa00670	1.27944046
24	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27739914
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27442992
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25894607
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24657779
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20465238
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18616363
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14383866
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13728977
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13246069
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06006322
34	Allograft rejection_Homo sapiens_hsa05330	1.05654052
35	Mismatch repair_Homo sapiens_hsa03430	1.05258416
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03616920
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01763690
38	Sulfur relay system_Homo sapiens_hsa04122	1.01394107
39	Basal transcription factors_Homo sapiens_hsa03022	1.00917105
40	Primary immunodeficiency_Homo sapiens_hsa05340	0.99809584
41	Purine metabolism_Homo sapiens_hsa00230	0.99036334
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.97661735
43	Graft-versus-host disease_Homo sapiens_hsa05332	0.96780574
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95727635
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.93490967
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93428042
47	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93426577
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93068598
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92160991
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90770621
51	Olfactory transduction_Homo sapiens_hsa04740	0.87967997
52	Folate biosynthesis_Homo sapiens_hsa00790	0.84224173
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83802257
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83530411
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82840040
56	Nicotine addiction_Homo sapiens_hsa05033	0.82575203
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.81699913
58	Peroxisome_Homo sapiens_hsa04146	0.78590910
59	RNA transport_Homo sapiens_hsa03013	0.78266616
60	Metabolic pathways_Homo sapiens_hsa01100	0.77307647
61	DNA replication_Homo sapiens_hsa03030	0.76749527
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74364177
63	Fatty acid elongation_Homo sapiens_hsa00062	0.74239848
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73974237
65	Base excision repair_Homo sapiens_hsa03410	0.72077930
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72008051
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.71752340
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70232003
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69678310
70	Regulation of autophagy_Homo sapiens_hsa04140	0.66498127
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65133197
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.62032740
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57850923
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.55568764
75	Retinol metabolism_Homo sapiens_hsa00830	0.55561591
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55165824
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.53250717
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52924713
79	Glutathione metabolism_Homo sapiens_hsa00480	0.50911906
80	Butanoate metabolism_Homo sapiens_hsa00650	0.50411106
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49324239
82	Spliceosome_Homo sapiens_hsa03040	0.42522441
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42123136
84	Circadian rhythm_Homo sapiens_hsa04710	0.42114298
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42053300
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38748438
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.37811335
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37660442
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31289322
90	Morphine addiction_Homo sapiens_hsa05032	0.29313495
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.27775322
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.27368053
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.26727609
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22806732
95	Caffeine metabolism_Homo sapiens_hsa00232	0.21109021
96	Sulfur metabolism_Homo sapiens_hsa00920	0.19416747
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.18404238
98	Serotonergic synapse_Homo sapiens_hsa04726	0.15595805
99	Taste transduction_Homo sapiens_hsa04742	0.15164801
100	Salivary secretion_Homo sapiens_hsa04970	0.14540763

RPS10P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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