ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.78765466
2	ribosomal small subunit biogenesis (GO:0042274)	8.15415732
3	viral transcription (GO:0019083)	7.94773970
4	translational termination (GO:0006415)	7.66886822
5	maturation of SSU-rRNA (GO:0030490)	6.99885905
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.59152342
7	translational elongation (GO:0006414)	6.59009506
8	cotranslational protein targeting to membrane (GO:0006613)	6.49570409
9	protein targeting to ER (GO:0045047)	6.43951045
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.19067231
11	protein localization to endoplasmic reticulum (GO:0070972)	6.03878769
12	cellular protein complex disassembly (GO:0043624)	5.81196370
13	viral life cycle (GO:0019058)	5.73340335
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.59934964
15	ATP synthesis coupled proton transport (GO:0015986)	5.47760349
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.47760349
17	translational initiation (GO:0006413)	5.22193651
18	ribosomal large subunit biogenesis (GO:0042273)	5.21061845
19	chaperone-mediated protein transport (GO:0072321)	5.08273428
20	protein complex disassembly (GO:0043241)	4.86575061
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.84082385
22	macromolecular complex disassembly (GO:0032984)	4.59743864
23	translation (GO:0006412)	4.51554973
24	ribonucleoprotein complex biogenesis (GO:0022613)	4.45406278
25	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.39295107
26	protein targeting to membrane (GO:0006612)	4.33469921
27	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.24338591
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.22689923
29	cellular component biogenesis (GO:0044085)	4.20575370
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.19676567
31	NADH dehydrogenase complex assembly (GO:0010257)	4.19676567
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.19676567
33	protein neddylation (GO:0045116)	4.19028828
34	protein complex biogenesis (GO:0070271)	4.11276192
35	base-excision repair, AP site formation (GO:0006285)	4.08525365
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.03760244
37	GTP biosynthetic process (GO:0006183)	3.99899832
38	respiratory electron transport chain (GO:0022904)	3.98599772
39	electron transport chain (GO:0022900)	3.97001155
40	behavioral response to nicotine (GO:0035095)	3.90013007
41	mRNA catabolic process (GO:0006402)	3.82251264
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.69553936
43	pyrimidine nucleotide catabolic process (GO:0006244)	3.68794407
44	ncRNA 3-end processing (GO:0043628)	3.59079355
45	ubiquinone biosynthetic process (GO:0006744)	3.58888473
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.57698801
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.57698801
48	rRNA processing (GO:0006364)	3.51421122
49	DNA deamination (GO:0045006)	3.48771085
50	pseudouridine synthesis (GO:0001522)	3.48134786
51	RNA catabolic process (GO:0006401)	3.44554357
52	UTP biosynthetic process (GO:0006228)	3.44358878
53	rRNA metabolic process (GO:0016072)	3.43755418
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41464769
55	water-soluble vitamin biosynthetic process (GO:0042364)	3.39662025
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.37702798
57	peptidyl-histidine modification (GO:0018202)	3.37237417
58	termination of RNA polymerase III transcription (GO:0006386)	3.35744537
59	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.35744537
60	ubiquinone metabolic process (GO:0006743)	3.28332264
61	ATP biosynthetic process (GO:0006754)	3.23011591
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.18754658
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15278962
64	CTP metabolic process (GO:0046036)	3.12107337
65	CTP biosynthetic process (GO:0006241)	3.12107337
66	protein polyglutamylation (GO:0018095)	3.10778299
67	hydrogen ion transmembrane transport (GO:1902600)	3.09372519
68	respiratory chain complex IV assembly (GO:0008535)	3.08784394
69	protein targeting to mitochondrion (GO:0006626)	3.08584314
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.08180940
71	UTP metabolic process (GO:0046051)	3.07834886
72	protein targeting (GO:0006605)	3.05463643
73	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.04417744
74	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.99786098
75	rRNA modification (GO:0000154)	2.96358561
76	establishment of protein localization to membrane (GO:0090150)	2.95775837
77	intracellular protein transmembrane import (GO:0044743)	2.94357994
78	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.93387530
79	ribosome biogenesis (GO:0042254)	2.92056132
80	protein-cofactor linkage (GO:0018065)	2.89610829
81	tRNA processing (GO:0008033)	2.89215894
82	establishment of protein localization to mitochondrion (GO:0072655)	2.88681617
83	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.87088929
84	iron-sulfur cluster assembly (GO:0016226)	2.86660498
85	metallo-sulfur cluster assembly (GO:0031163)	2.86660498
86	proton transport (GO:0015992)	2.86355301
87	deoxyribonucleotide catabolic process (GO:0009264)	2.83556205
88	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.81502751
89	deoxyribose phosphate catabolic process (GO:0046386)	2.81339003
90	quinone biosynthetic process (GO:1901663)	2.79813953
91	hydrogen transport (GO:0006818)	2.79788142
92	establishment of protein localization to organelle (GO:0072594)	2.78854097
93	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.76871787
94	guanosine-containing compound biosynthetic process (GO:1901070)	2.76111023
95	ncRNA processing (GO:0034470)	2.74615274
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70740848
97	protein localization to mitochondrion (GO:0070585)	2.69346543
98	negative regulation of T cell differentiation in thymus (GO:0033085)	2.68659732
99	nucleoside triphosphate biosynthetic process (GO:0009142)	2.67567492
100	cell proliferation in forebrain (GO:0021846)	2.67361553

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.51001322
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.30411621
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.74096237
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.65893775
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.61033138
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.44916697
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.43492643
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.27969457
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.11678479
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80601875
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.77012574
12	VDR_22108803_ChIP-Seq_LS180_Human	2.53979556
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.43759344
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.23894724
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.23560850
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.19529784
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17021818
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12579515
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10426111
20	TTF2_22483619_ChIP-Seq_HELA_Human	2.06073907
21	XRN2_22483619_ChIP-Seq_HELA_Human	1.96739409
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91609199
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.90617568
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.90314918
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.88923377
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.86680894
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.85428096
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.82846292
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.78308305
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77685358
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.74996160
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.73415750
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72684847
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.61356678
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56887491
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56705166
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.55236380
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53274038
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38263940
40	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.38026681
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.34671790
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.31213719
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31208649
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.28380909
45	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.27114621
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25474961
47	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23129190
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23039201
49	EWS_26573619_Chip-Seq_HEK293_Human	1.21325557
50	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.19647282
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19156110
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.16811742
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16258807
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16051915
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.15301678
56	ERA_21632823_ChIP-Seq_H3396_Human	1.12922132
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12508547
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12251939
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11867567
60	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.10771971
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10092058
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09920186
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09783511
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09547716
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.08185356
66	NCOR_22424771_ChIP-Seq_293T_Human	1.07884375
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07442123
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07278066
69	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.04387963
70	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04330544
71	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03796807
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02533019
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02074741
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00838825
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.00697921
76	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00078578
77	STAT1_20625510_ChIP-Seq_HELA_Human	0.98106126
78	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97943385
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96210687
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94826705
81	AR_20517297_ChIP-Seq_VCAP_Human	0.93391318
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93093249
83	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92152164
84	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.92013619
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91914729
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88759013
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88452064
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87723963
89	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.87701619
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87310525
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87098115
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86668678
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86462354
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.85873868
95	RNF2_27304074_Chip-Seq_NSC_Mouse	0.85822621
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85794624
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.83940102
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83837850
99	FUS_26573619_Chip-Seq_HEK293_Human	0.83313077
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83112914

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.12048105
2	MP0006292_abnormal_olfactory_placode	4.26451785
3	MP0002163_abnormal_gland_morphology	2.81800985
4	MP0003787_abnormal_imprinting	2.50696386
5	MP0005646_abnormal_pituitary_gland	2.35653631
6	MP0002653_abnormal_ependyma_morphology	2.34956538
7	MP0008877_abnormal_DNA_methylation	2.31486721
8	MP0003878_abnormal_ear_physiology	2.27269878
9	MP0005377_hearing/vestibular/ear_phenot	2.27269878
10	MP0008789_abnormal_olfactory_epithelium	2.16911817
11	MP0004142_abnormal_muscle_tone	2.09808791
12	MP0003123_paternal_imprinting	1.97052275
13	MP0002638_abnormal_pupillary_reflex	1.96626082
14	MP0002102_abnormal_ear_morphology	1.94579129
15	MP0001986_abnormal_taste_sensitivity	1.83617821
16	MP0008058_abnormal_DNA_repair	1.79985937
17	MP0006276_abnormal_autonomic_nervous	1.74996006
18	MP0005499_abnormal_olfactory_system	1.74472050
19	MP0005394_taste/olfaction_phenotype	1.74472050
20	MP0004885_abnormal_endolymph	1.74322317
21	MP0005379_endocrine/exocrine_gland_phen	1.72762432
22	MP0003186_abnormal_redox_activity	1.69496871
23	MP0008872_abnormal_physiological_respon	1.65926205
24	MP0003122_maternal_imprinting	1.65509073
25	MP0001968_abnormal_touch/_nociception	1.62714274
26	MP0000049_abnormal_middle_ear	1.59673629
27	MP0002938_white_spotting	1.57842589
28	MP0001293_anophthalmia	1.55948537
29	MP0003786_premature_aging	1.53526127
30	MP0003646_muscle_fatigue	1.53503841
31	MP0005389_reproductive_system_phenotype	1.51503787
32	MP0002095_abnormal_skin_pigmentation	1.50683222
33	MP0004147_increased_porphyrin_level	1.50519676
34	MP0002234_abnormal_pharynx_morphology	1.48999797
35	MP0002160_abnormal_reproductive_system	1.48814042
36	MP0006072_abnormal_retinal_apoptosis	1.47312892
37	MP0005075_abnormal_melanosome_morpholog	1.47240244
38	MP0002138_abnormal_hepatobiliary_system	1.47186743
39	MP0001485_abnormal_pinna_reflex	1.45068317
40	MP0002837_dystrophic_cardiac_calcinosis	1.43519873
41	MP0000372_irregular_coat_pigmentation	1.40464790
42	MP0001919_abnormal_reproductive_system	1.40177844
43	MP0002876_abnormal_thyroid_physiology	1.39528440
44	MP0003121_genomic_imprinting	1.37775335
45	MP0004742_abnormal_vestibular_system	1.37118426
46	MP0005551_abnormal_eye_electrophysiolog	1.36866740
47	MP0004145_abnormal_muscle_electrophysio	1.36831965
48	MP0000631_abnormal_neuroendocrine_gland	1.33487468
49	MP0001529_abnormal_vocalization	1.32353799
50	MP0002272_abnormal_nervous_system	1.31937818
51	MP0008875_abnormal_xenobiotic_pharmacok	1.31586611
52	MP0002736_abnormal_nociception_after	1.31200044
53	MP0010030_abnormal_orbit_morphology	1.19890854
54	MP0003136_yellow_coat_color	1.16591460
55	MP0001905_abnormal_dopamine_level	1.14699600
56	MP0005174_abnormal_tail_pigmentation	1.13771481
57	MP0001502_abnormal_circadian_rhythm	1.12017419
58	MP0008995_early_reproductive_senescence	1.10474013
59	MP0009745_abnormal_behavioral_response	1.10212359
60	MP0003693_abnormal_embryo_hatching	1.07971606
61	MP0003880_abnormal_central_pattern	1.07394431
62	MP0000778_abnormal_nervous_system	1.06819263
63	MP0004133_heterotaxia	1.04141283
64	MP0002210_abnormal_sex_determination	1.04012032
65	MP0003195_calcinosis	1.02986370
66	MP0006036_abnormal_mitochondrial_physio	1.02680324
67	MP0005645_abnormal_hypothalamus_physiol	1.02598054
68	MP0001984_abnormal_olfaction	1.01099359
69	MP0003879_abnormal_hair_cell	1.00062959
70	MP0005195_abnormal_posterior_eye	1.00050615
71	MP0002277_abnormal_respiratory_mucosa	0.98092590
72	MP0001440_abnormal_grooming_behavior	0.97685342
73	MP0003567_abnormal_fetal_cardiomyocyte	0.97322313
74	MP0000026_abnormal_inner_ear	0.96276914
75	MP0009046_muscle_twitch	0.96125576
76	MP0002733_abnormal_thermal_nociception	0.93826438
77	MP0003011_delayed_dark_adaptation	0.88811558
78	MP0001970_abnormal_pain_threshold	0.87858759
79	MP0002752_abnormal_somatic_nervous	0.87782476
80	MP0000015_abnormal_ear_pigmentation	0.85796449
81	MP0003937_abnormal_limbs/digits/tail_de	0.85581758
82	MP0006035_abnormal_mitochondrial_morpho	0.84187127
83	MP0000653_abnormal_sex_gland	0.83302120
84	MP0002557_abnormal_social/conspecific_i	0.81804112
85	MP0001145_abnormal_male_reproductive	0.81492155
86	MP0003938_abnormal_ear_development	0.80563302
87	MP0003936_abnormal_reproductive_system	0.79748589
88	MP0001963_abnormal_hearing_physiology	0.78484773
89	MP0000613_abnormal_salivary_gland	0.77741840
90	MP0000566_synostosis	0.77588719
91	MP0002572_abnormal_emotion/affect_behav	0.75438479
92	MP0001188_hyperpigmentation	0.74950927
93	MP0001929_abnormal_gametogenesis	0.73789791
94	MP0002184_abnormal_innervation	0.73489890
95	MP0008775_abnormal_heart_ventricle	0.71968701
96	MP0003718_maternal_effect	0.70599495
97	MP0005636_abnormal_mineral_homeostasis	0.69873165
98	MP0002233_abnormal_nose_morphology	0.69416269
99	MP0005084_abnormal_gallbladder_morpholo	0.68819822
100	MP0005253_abnormal_eye_physiology	0.68140422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.59256322
2	Acute necrotizing encephalopathy (HP:0006965)	5.11216646
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.64592783
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.57740601
5	Acute encephalopathy (HP:0006846)	4.56382375
6	Progressive macrocephaly (HP:0004481)	4.12281026
7	Mitochondrial inheritance (HP:0001427)	4.09559135
8	Increased CSF lactate (HP:0002490)	3.89358499
9	Macrocytic anemia (HP:0001972)	3.79996458
10	Pancreatic fibrosis (HP:0100732)	3.64799672
11	Molar tooth sign on MRI (HP:0002419)	3.58264322
12	Abnormality of midbrain morphology (HP:0002418)	3.58264322
13	Abnormal number of erythroid precursors (HP:0012131)	3.52430201
14	Pallor (HP:0000980)	3.39778643
15	Pancreatic cysts (HP:0001737)	3.38890144
16	Hepatocellular necrosis (HP:0001404)	3.33755610
17	Congenital stationary night blindness (HP:0007642)	3.24813503
18	True hermaphroditism (HP:0010459)	3.18862440
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.14826395
20	Cerebral edema (HP:0002181)	3.14485048
21	Colon cancer (HP:0003003)	3.10306784
22	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.09599084
23	Hepatic necrosis (HP:0002605)	3.07551103
24	3-Methylglutaconic aciduria (HP:0003535)	2.98001419
25	Absent thumb (HP:0009777)	2.82343730
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.81752687
27	Increased hepatocellular lipid droplets (HP:0006565)	2.80021825
28	Sclerocornea (HP:0000647)	2.78226609
29	Optic disc pallor (HP:0000543)	2.74496088
30	Abnormal hemoglobin (HP:0011902)	2.64456260
31	Nephronophthisis (HP:0000090)	2.62952640
32	Septo-optic dysplasia (HP:0100842)	2.59144532
33	Increased serum lactate (HP:0002151)	2.59026220
34	Lactic acidosis (HP:0003128)	2.57566607
35	Lipid accumulation in hepatocytes (HP:0006561)	2.55000992
36	Hyperglycinemia (HP:0002154)	2.49864485
37	Anencephaly (HP:0002323)	2.49059650
38	Increased intramyocellular lipid droplets (HP:0012240)	2.47006536
39	Renal Fanconi syndrome (HP:0001994)	2.46848650
40	Pendular nystagmus (HP:0012043)	2.40921090
41	Stenosis of the external auditory canal (HP:0000402)	2.39160733
42	Type II lissencephaly (HP:0007260)	2.38797367
43	Medial flaring of the eyebrow (HP:0010747)	2.35338706
44	Asplenia (HP:0001746)	2.27862509
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.27436485
46	Abnormality of the renal medulla (HP:0100957)	2.23873143
47	Respiratory failure (HP:0002878)	2.23683776
48	Microretrognathia (HP:0000308)	2.21081421
49	Cystic liver disease (HP:0006706)	2.18431475
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.18191808
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.18191808
52	Leukodystrophy (HP:0002415)	2.14884472
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12093446
54	Male pseudohermaphroditism (HP:0000037)	2.08704128
55	Lethargy (HP:0001254)	2.08657567
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06693134
57	Postaxial foot polydactyly (HP:0001830)	2.06219848
58	Abnormality of the labia minora (HP:0012880)	2.05594320
59	Exercise intolerance (HP:0003546)	2.00443659
60	Abnormality of the renal cortex (HP:0011035)	1.99960703
61	Hypoplasia of the radius (HP:0002984)	1.99860046
62	Increased muscle lipid content (HP:0009058)	1.99151658
63	Depressed nasal ridge (HP:0000457)	1.98434068
64	Rib fusion (HP:0000902)	1.91329380
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89035681
66	Abnormality of alanine metabolism (HP:0010916)	1.89035681
67	Hyperalaninemia (HP:0003348)	1.89035681
68	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86947879
69	Exertional dyspnea (HP:0002875)	1.85873357
70	Abnormality of the anterior horn cell (HP:0006802)	1.81012262
71	Degeneration of anterior horn cells (HP:0002398)	1.81012262
72	Abnormality of DNA repair (HP:0003254)	1.80958741
73	Abolished electroretinogram (ERG) (HP:0000550)	1.80024083
74	Optic nerve coloboma (HP:0000588)	1.78625248
75	Triphalangeal thumb (HP:0001199)	1.78561331
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78388412
77	Hypoplasia of the ulna (HP:0003022)	1.75868538
78	Tubular atrophy (HP:0000092)	1.75365499
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75142127
80	Horseshoe kidney (HP:0000085)	1.74327269
81	Gait imbalance (HP:0002141)	1.72678318
82	Abnormality of renal resorption (HP:0011038)	1.71804460
83	Type 2 muscle fiber atrophy (HP:0003554)	1.70948436
84	Congenital primary aphakia (HP:0007707)	1.70802299
85	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.70268905
86	Constricted visual fields (HP:0001133)	1.69945419
87	Glycosuria (HP:0003076)	1.69664764
88	Abnormality of urine glucose concentration (HP:0011016)	1.69664764
89	Nephrogenic diabetes insipidus (HP:0009806)	1.69206674
90	Hyperthyroidism (HP:0000836)	1.69114437
91	Preaxial hand polydactyly (HP:0001177)	1.67541473
92	Maternal diabetes (HP:0009800)	1.67465055
93	Holoprosencephaly (HP:0001360)	1.66918391
94	Forearm undergrowth (HP:0009821)	1.64806704
95	Congenital hepatic fibrosis (HP:0002612)	1.64743929
96	Partial duplication of thumb phalanx (HP:0009944)	1.64576282
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.63497940
98	Pachygyria (HP:0001302)	1.62843984
99	Synostosis involving the elbow (HP:0003938)	1.62634311
100	Humeroradial synostosis (HP:0003041)	1.62634311

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.71726824
2	CDK19	3.01739288
3	WNK4	2.99222881
4	PINK1	2.82388482
5	VRK2	2.68892742
6	BCKDK	2.60762808
7	ADRBK2	2.38484436
8	NME2	2.29029916
9	PIK3CA	2.28949018
10	GRK1	2.28399293
11	ZAK	2.16317153
12	TLK1	2.13212322
13	CDC7	2.06468360
14	DYRK2	2.04505680
15	MAP4K2	2.00941102
16	STK16	1.98746518
17	PDK2	1.91621285
18	NEK1	1.87022292
19	LRRK2	1.81957547
20	PASK	1.53685297
21	CAMKK2	1.46667417
22	STK39	1.46019684
23	TXK	1.37684880
24	MAP3K11	1.29459680
25	WNK3	1.28313630
26	PLK4	1.27213843
27	VRK1	1.26868423
28	SRPK1	1.25653381
29	NME1	1.24217403
30	ABL2	1.11342455
31	BMPR1B	1.07006017
32	BRAF	1.05405307
33	PRKCG	1.04564300
34	DMPK	1.03733844
35	PAK3	0.92243829
36	CAMK1	0.90187895
37	OXSR1	0.89945505
38	ADRBK1	0.88993822
39	CSNK1G2	0.88468650
40	PRKCQ	0.88363662
41	TAOK3	0.87792878
42	FRK	0.87533683
43	BUB1	0.85788906
44	AURKB	0.83173815
45	IKBKB	0.82245072
46	MATK	0.78550701
47	CSNK2A2	0.77644172
48	CSNK1G3	0.77182841
49	TEC	0.76884878
50	TIE1	0.76453858
51	LIMK1	0.76215710
52	PRKCI	0.74950919
53	INSRR	0.73569502
54	RPS6KA5	0.72647107
55	PLK1	0.72240203
56	AURKA	0.71929474
57	PHKG2	0.71771395
58	PHKG1	0.71771395
59	WNK1	0.69266368
60	ACVR1B	0.68276234
61	CAMKK1	0.65089155
62	DAPK3	0.64549180
63	CSNK2A1	0.64320592
64	TAF1	0.64265166
65	STK11	0.62558361
66	PRKACA	0.60609779
67	ITK	0.57261043
68	ATR	0.54040535
69	NTRK2	0.53315064
70	MAPK13	0.51770781
71	MINK1	0.51686992
72	PRKCH	0.50644333
73	PLK2	0.50515108
74	PRKCE	0.49300810
75	CSNK1G1	0.49185518
76	PLK3	0.48884309
77	MKNK2	0.48593382
78	NTRK1	0.47931117
79	CHEK2	0.47532255
80	EPHA4	0.45910088
81	ARAF	0.45107691
82	RPS6KA6	0.44327051
83	CSNK1E	0.43867970
84	PRKCD	0.43618321
85	MUSK	0.43102498
86	PRKCA	0.42958935
87	MAP2K2	0.42943966
88	CSNK1A1L	0.42798118
89	TYRO3	0.42771362
90	EPHB2	0.40678696
91	PIM2	0.39970201
92	KIT	0.37681126
93	CAMK2A	0.37043124
94	NEK2	0.35369093
95	OBSCN	0.34207158
96	CAMK2D	0.34055419
97	TGFBR1	0.34044749
98	CDK8	0.33662988
99	MAP2K7	0.31217935
100	GRK5	0.31160199

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.62545123
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.22219993
3	Parkinsons disease_Homo sapiens_hsa05012	3.50431941
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.03390914
5	RNA polymerase_Homo sapiens_hsa03020	2.82922341
6	Proteasome_Homo sapiens_hsa03050	2.58107680
7	Huntingtons disease_Homo sapiens_hsa05016	2.50920763
8	Alzheimers disease_Homo sapiens_hsa05010	2.29125784
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.26039534
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15498864
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11753267
12	Protein export_Homo sapiens_hsa03060	2.07785265
13	One carbon pool by folate_Homo sapiens_hsa00670	1.95271973
14	Base excision repair_Homo sapiens_hsa03410	1.83655251
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78095379
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62039061
17	Homologous recombination_Homo sapiens_hsa03440	1.59339616
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.57400498
19	Asthma_Homo sapiens_hsa05310	1.55811606
20	Basal transcription factors_Homo sapiens_hsa03022	1.54824519
21	RNA degradation_Homo sapiens_hsa03018	1.52518744
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40179588
23	Mismatch repair_Homo sapiens_hsa03430	1.36264636
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34407169
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28699888
26	DNA replication_Homo sapiens_hsa03030	1.27175862
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.25131813
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22597383
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21167125
30	Phototransduction_Homo sapiens_hsa04744	1.20023508
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19447525
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.18318843
33	Propanoate metabolism_Homo sapiens_hsa00640	1.14797703
34	Peroxisome_Homo sapiens_hsa04146	1.14665756
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13030905
36	Sulfur relay system_Homo sapiens_hsa04122	1.08853916
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.07778618
38	RNA transport_Homo sapiens_hsa03013	1.03042177
39	Purine metabolism_Homo sapiens_hsa00230	1.00421483
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96797973
41	Spliceosome_Homo sapiens_hsa03040	0.95094058
42	Sulfur metabolism_Homo sapiens_hsa00920	0.92960459
43	Allograft rejection_Homo sapiens_hsa05330	0.92909754
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.92571007
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90115049
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88659974
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86465435
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85323844
49	Metabolic pathways_Homo sapiens_hsa01100	0.84215817
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.80968905
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80078173
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77862677
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.76816361
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76162056
55	Folate biosynthesis_Homo sapiens_hsa00790	0.74291331
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70996814
57	Nicotine addiction_Homo sapiens_hsa05033	0.68193062
58	Fatty acid elongation_Homo sapiens_hsa00062	0.66072167
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.66065217
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65645210
61	Butanoate metabolism_Homo sapiens_hsa00650	0.65624597
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.64800638
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.64663197
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62322637
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62014180
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61317999
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53514456
68	Caffeine metabolism_Homo sapiens_hsa00232	0.53287211
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53262858
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.52836957
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49612408
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.46188487
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44955247
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.44927808
75	Fatty acid degradation_Homo sapiens_hsa00071	0.43814944
76	Morphine addiction_Homo sapiens_hsa05032	0.43381234
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43105342
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42490991
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41089930
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40596402
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39658952
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39513448
83	Olfactory transduction_Homo sapiens_hsa04740	0.39006748
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35872733
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.35562547
86	Retinol metabolism_Homo sapiens_hsa00830	0.35422517
87	Regulation of autophagy_Homo sapiens_hsa04140	0.35118077
88	Glutathione metabolism_Homo sapiens_hsa00480	0.31774926
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30860342
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30399443
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.29405385
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28585656
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25432053
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23333249
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19436271
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.15806870
97	p53 signaling pathway_Homo sapiens_hsa04115	0.15222198
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.14530550
99	Carbon metabolism_Homo sapiens_hsa01200	0.12912770
100	Taste transduction_Homo sapiens_hsa04742	0.12386142

RPS10P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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