RPS11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.38458888
2* viral transcription (GO:0019083)7.91722115
3* translational termination (GO:0006415)7.62018251
4ribosomal small subunit biogenesis (GO:0042274)7.36966742
5maturation of SSU-rRNA (GO:0030490)6.65398085
6* translational elongation (GO:0006414)6.59350166
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.52957635
8* cotranslational protein targeting to membrane (GO:0006613)6.39464991
9* protein targeting to ER (GO:0045047)6.37552123
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.06866693
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.01477859
12* protein localization to endoplasmic reticulum (GO:0070972)5.98468197
13* viral life cycle (GO:0019058)5.92538220
14* cellular protein complex disassembly (GO:0043624)5.89250112
15* translational initiation (GO:0006413)5.81474966
16ribosomal large subunit biogenesis (GO:0042273)5.40958692
17* protein complex disassembly (GO:0043241)5.19346303
18* macromolecular complex disassembly (GO:0032984)4.86838566
19DNA deamination (GO:0045006)4.58328660
20ribonucleoprotein complex biogenesis (GO:0022613)4.55230594
21* nuclear-transcribed mRNA catabolic process (GO:0000956)4.49183041
22* translation (GO:0006412)4.35110458
23formation of translation preinitiation complex (GO:0001731)4.33778115
24* mRNA catabolic process (GO:0006402)4.25930236
25* protein targeting to membrane (GO:0006612)4.18277681
26DNA strand elongation involved in DNA replication (GO:0006271)4.12160533
27telomere maintenance via semi-conservative replication (GO:0032201)4.08607280
28* RNA catabolic process (GO:0006401)4.01143921
29DNA strand elongation (GO:0022616)3.91922664
30rRNA processing (GO:0006364)3.77298476
31rRNA metabolic process (GO:0016072)3.63325588
32telomere maintenance via recombination (GO:0000722)3.62893075
33* protein localization to membrane (GO:0072657)3.59123672
34DNA replication initiation (GO:0006270)3.49364542
35cellular component biogenesis (GO:0044085)3.44399004
36mitotic recombination (GO:0006312)3.36889603
37DNA unwinding involved in DNA replication (GO:0006268)3.34447445
38negative regulation of erythrocyte differentiation (GO:0045647)3.29588683
39regulation of translational fidelity (GO:0006450)3.28945853
40proteasome assembly (GO:0043248)3.27885415
41telomere maintenance via telomere lengthening (GO:0010833)3.22156838
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21427693
43ribosome biogenesis (GO:0042254)3.19832427
44myeloid cell homeostasis (GO:0002262)3.18868843
45DNA replication checkpoint (GO:0000076)3.18796390
46spliceosomal snRNP assembly (GO:0000387)3.16729689
47nucleobase biosynthetic process (GO:0046112)3.13906916
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12805529
49* cellular component disassembly (GO:0022411)3.09127381
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.08558465
51establishment of integrated proviral latency (GO:0075713)3.07991385
52pseudouridine synthesis (GO:0001522)3.07206923
53CENP-A containing nucleosome assembly (GO:0034080)3.04046275
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.01796467
55termination of RNA polymerase III transcription (GO:0006386)3.01796467
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00608275
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99437179
58ATP synthesis coupled proton transport (GO:0015986)2.97325738
59energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97325738
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97135434
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96945604
62transcription-coupled nucleotide-excision repair (GO:0006283)2.96267116
63chromatin remodeling at centromere (GO:0031055)2.96147436
64negative regulation of ligase activity (GO:0051352)2.95637983
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95637983
66spliceosomal complex assembly (GO:0000245)2.95554747
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93546840
68negative regulation of RNA splicing (GO:0033119)2.90056109
69ribosome assembly (GO:0042255)2.89966178
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89492376
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89492376
72purine nucleobase biosynthetic process (GO:0009113)2.89093422
73* protein localization to organelle (GO:0033365)2.88729524
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88334707
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87762523
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87762523
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87762523
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85447187
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.83888718
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83888718
81kinetochore organization (GO:0051383)2.80256086
82* establishment of protein localization to membrane (GO:0090150)2.80185919
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.79324540
84* gene expression (GO:0010467)2.78973248
85DNA replication-independent nucleosome organization (GO:0034724)2.78652480
86DNA replication-independent nucleosome assembly (GO:0006336)2.78652480
87protein localization to kinetochore (GO:0034501)2.78098265
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.74191144
89rRNA modification (GO:0000154)2.73270265
90viral mRNA export from host cell nucleus (GO:0046784)2.72205903
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68219985
92ncRNA processing (GO:0034470)2.68075662
93DNA topological change (GO:0006265)2.67195096
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65996988
95* establishment of protein localization to organelle (GO:0072594)2.65751942
96termination of RNA polymerase I transcription (GO:0006363)2.64809267
97kinetochore assembly (GO:0051382)2.63701939
98cell cycle G1/S phase transition (GO:0044843)2.63254344
99G1/S transition of mitotic cell cycle (GO:0000082)2.63254344
100ribonucleoprotein complex assembly (GO:0022618)2.62733895
101* protein targeting (GO:0006605)2.62170810
102histone mRNA metabolic process (GO:0008334)2.62155973
103mitotic chromosome condensation (GO:0007076)2.61568175
104regulation of cellular amino acid metabolic process (GO:0006521)2.60284406
1057-methylguanosine mRNA capping (GO:0006370)2.59637013
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59299604
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.58936886
108IMP biosynthetic process (GO:0006188)2.58243376
109RNA splicing, via transesterification reactions (GO:0000375)2.57106868
110RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56970333
111mRNA splicing, via spliceosome (GO:0000398)2.56970333
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.56183272
1137-methylguanosine RNA capping (GO:0009452)2.55982107
114viral protein processing (GO:0019082)2.55084070
115protein-DNA complex disassembly (GO:0032986)2.54599797
116nucleosome disassembly (GO:0006337)2.54599797
117positive thymic T cell selection (GO:0045059)2.52473643
118heterochromatin organization (GO:0070828)2.49488460
119modulation by virus of host process (GO:0019054)2.47260323
120ribonucleoprotein complex subunit organization (GO:0071826)2.46990273
121regulation of RNA export from nucleus (GO:0046831)2.41530503
122regulation of histone H3-K27 methylation (GO:0061085)2.35893797
123establishment of protein localization to mitochondrial membrane (GO:0090151)2.35322340
124negative regulation of DNA repair (GO:0045738)2.34224067
125negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.31064820
126positive regulation of gamma-delta T cell activation (GO:0046645)2.30196980
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.29660138
128regulation of chromatin binding (GO:0035561)2.28938921
129positive regulation by host of viral transcription (GO:0043923)2.28567812
130negative regulation of translational initiation (GO:0045947)2.27877166
1313-UTR-mediated mRNA stabilization (GO:0070935)2.27376295
132innate immune response in mucosa (GO:0002227)2.24021695
133mRNA stabilization (GO:0048255)2.18906905
134RNA stabilization (GO:0043489)2.18906905
135thymic T cell selection (GO:0045061)2.18808687
136negative regulation of histone methylation (GO:0031061)2.18275895
137negative regulation of DNA-templated transcription, elongation (GO:0032785)2.17188547
138positive regulation of B cell differentiation (GO:0045579)2.15032898
139chromatin assembly (GO:0031497)2.14705260
140inner mitochondrial membrane organization (GO:0007007)2.12922610
141positive regulation of viral transcription (GO:0050434)2.10965167
142negative regulation of mRNA processing (GO:0050686)2.09719625
143pentose-phosphate shunt (GO:0006098)2.08861632
144nuclear pore complex assembly (GO:0051292)2.07290685
145antibacterial humoral response (GO:0019731)2.06476012
146pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.06458997
147ncRNA 3-end processing (GO:0043628)2.05578149
148regulation of histone H3-K4 methylation (GO:0051569)2.05077228
149* single-organism cellular localization (GO:1902580)2.03269228
150regulation of histone methylation (GO:0031060)2.03045570
151regulation of translational initiation (GO:0006446)2.00187509
152negative regulation of mRNA metabolic process (GO:1903312)2.00180165
153positive T cell selection (GO:0043368)1.99893485
154regulation of mammary gland epithelial cell proliferation (GO:0033599)1.99418859
155T cell apoptotic process (GO:0070231)1.99241159
156virion assembly (GO:0019068)1.98213771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77141209
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49955226
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97944042
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46445228
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.32145212
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25988238
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18711277
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09846281
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00620199
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95377152
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86366947
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80661055
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.75540377
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73742332
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66759674
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66524393
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65175018
18XRN2_22483619_ChIP-Seq_HELA_Human2.57417755
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51634436
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39902550
21* VDR_23849224_ChIP-Seq_CD4+_Human2.37400356
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20269555
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20111966
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18653830
25FOXP3_21729870_ChIP-Seq_TREG_Human2.07502671
26* TTF2_22483619_ChIP-Seq_HELA_Human2.04503437
27DCP1A_22483619_ChIP-Seq_HELA_Human2.03960698
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03831959
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98910892
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97072745
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93159847
32ELK1_19687146_ChIP-ChIP_HELA_Human1.90769486
33GABP_19822575_ChIP-Seq_HepG2_Human1.75097776
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73535250
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70887822
36MYC_22102868_ChIP-Seq_BL_Human1.67813274
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66147880
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59683364
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59260799
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57826209
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57300120
42* CIITA_25753668_ChIP-Seq_RAJI_Human1.56751284
43* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56188089
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55638042
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.53844920
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.51523641
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51286979
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50657985
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48495200
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48364740
51LXR_22292898_ChIP-Seq_THP-1_Human1.47561572
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.46872764
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45866152
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45731730
55AR_21909140_ChIP-Seq_LNCAP_Human1.43427737
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.42671316
57MAF_26560356_Chip-Seq_TH2_Human1.41905783
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.41704600
59* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40245113
60VDR_21846776_ChIP-Seq_THP-1_Human1.39605214
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38093165
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37659781
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36404754
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34642093
65VDR_24763502_ChIP-Seq_THP-1_Human1.32948557
66TCF7_22412390_ChIP-Seq_EML_Mouse1.32215723
67* SPI1_23547873_ChIP-Seq_NB4_Human1.31570210
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.31510518
69NCOR1_26117541_ChIP-Seq_K562_Human1.29642737
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29434273
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28810471
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.28047249
73* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25692204
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22783653
75KDM2B_26808549_Chip-Seq_DND41_Human1.22418552
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.22406138
77KDM5A_27292631_Chip-Seq_BREAST_Human1.21036795
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17066941
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17021098
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.14508675
81* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14213774
82* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12550786
83RACK7_27058665_Chip-Seq_MCF-7_Human1.11312143
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.10495624
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09917099
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.08975471
87* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07919368
88P68_20966046_ChIP-Seq_HELA_Human1.07505094
89MYC_18940864_ChIP-ChIP_HL60_Human1.07188539
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07094943
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06916718
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06025946
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05840617
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05817863
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05492491
96ZNF263_19887448_ChIP-Seq_K562_Human1.03154428
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02730495
98* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01948188
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01822075
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01316792
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99779704
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99424314
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98998660
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98820668
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98762817
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98736424
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98074797
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98043464
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.98007161
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97435961
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97414246
112* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97125226
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96998107
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.96955128
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.96870258
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.96129150
117TFEB_21752829_ChIP-Seq_HELA_Human0.96118136
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95691927
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95257506
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95052443
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93765710
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93750727
123* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93188289
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92247293
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90806700
126SCL_19346495_ChIP-Seq_HPC-7_Human0.90289355
127* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88779778
128MYB_26560356_Chip-Seq_TH2_Human0.86796718
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86181181
130UTX_26944678_Chip-Seq_JUKART_Human0.85570734
131MAF_26560356_Chip-Seq_TH1_Human0.85478531
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85200862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.55128923
2MP0004957_abnormal_blastocyst_morpholog3.62494764
3MP0009379_abnormal_foot_pigmentation3.46626938
4MP0010094_abnormal_chromosome_stability3.33109019
5MP0003077_abnormal_cell_cycle3.16731814
6MP0003111_abnormal_nucleus_morphology3.12064894
7MP0008057_abnormal_DNA_replication2.91430936
8MP0002396_abnormal_hematopoietic_system2.87727930
9MP0008058_abnormal_DNA_repair2.58726413
10MP0006292_abnormal_olfactory_placode2.44395747
11MP0008007_abnormal_cellular_replicative2.43458836
12MP0000566_synostosis2.39166995
13MP0003763_abnormal_thymus_physiology2.23472189
14MP0000490_abnormal_crypts_of2.07089705
15MP0001835_abnormal_antigen_presentation2.05646776
16MP0009333_abnormal_splenocyte_physiolog2.05629668
17MP0003786_premature_aging1.95916071
18MP0008932_abnormal_embryonic_tissue1.94862470
19MP0004808_abnormal_hematopoietic_stem1.78169261
20MP0004185_abnormal_adipocyte_glucose1.76802392
21MP0002398_abnormal_bone_marrow1.70837565
22MP0005671_abnormal_response_to1.67548616
23MP0010352_gastrointestinal_tract_polyps1.64987415
24MP0000685_abnormal_immune_system1.64393245
25MP0006054_spinal_hemorrhage1.61835076
26MP0001545_abnormal_hematopoietic_system1.61613874
27MP0005397_hematopoietic_system_phenotyp1.61613874
28MP0000350_abnormal_cell_proliferation1.59524518
29MP0002722_abnormal_immune_system1.55143401
30MP0001853_heart_inflammation1.54304590
31MP0001800_abnormal_humoral_immune1.54100060
32MP0001730_embryonic_growth_arrest1.52847633
33MP0000703_abnormal_thymus_morphology1.48211253
34MP0002163_abnormal_gland_morphology1.46879022
35MP0000689_abnormal_spleen_morphology1.46828150
36MP0005174_abnormal_tail_pigmentation1.45528793
37MP0002009_preneoplasia1.43860163
38MP0002132_abnormal_respiratory_system1.43812912
39MP0002019_abnormal_tumor_incidence1.42685332
40MP0003123_paternal_imprinting1.42665421
41MP0009785_altered_susceptibility_to1.42433654
42MP0002420_abnormal_adaptive_immunity1.40551506
43MP0001819_abnormal_immune_cell1.38217154
44MP0002452_abnormal_antigen_presenting1.37591356
45MP0002429_abnormal_blood_cell1.36350634
46MP0000716_abnormal_immune_system1.35733147
47MP0003136_yellow_coat_color1.34497588
48MP0002166_altered_tumor_susceptibility1.34099969
49MP0003938_abnormal_ear_development1.33231506
50MP0003315_abnormal_perineum_morphology1.32312666
51MP0003567_abnormal_fetal_cardiomyocyte1.31004346
52MP0000313_abnormal_cell_death1.29619815
53MP0002723_abnormal_immune_serum1.28025176
54MP0005025_abnormal_response_to1.26444568
55MP0005075_abnormal_melanosome_morpholog1.26370456
56MP0002405_respiratory_system_inflammati1.24935466
57MP0002249_abnormal_larynx_morphology1.24845059
58MP0002148_abnormal_hypersensitivity_rea1.24828326
59MP0005000_abnormal_immune_tolerance1.23988802
60MP0000858_altered_metastatic_potential1.22321504
61MP0001873_stomach_inflammation1.20238597
62MP0005451_abnormal_body_composition1.19454978
63MP0010155_abnormal_intestine_physiology1.18470282
64MP0002006_tumorigenesis1.18156444
65MP0003436_decreased_susceptibility_to1.15997029
66MP0000465_gastrointestinal_hemorrhage1.15311225
67MP0003186_abnormal_redox_activity1.13909391
68MP0002796_impaired_skin_barrier1.11956844
69MP0002095_abnormal_skin_pigmentation1.10578942
70MP0002080_prenatal_lethality1.09447951
71MP0001697_abnormal_embryo_size1.08397991
72MP0003718_maternal_effect1.07160929
73MP0000678_abnormal_parathyroid_gland1.06308676
74MP0004264_abnormal_extraembryonic_tissu1.03521261
75MP0005380_embryogenesis_phenotype1.00923226
76MP0001672_abnormal_embryogenesis/_devel1.00923226
77MP0003866_abnormal_defecation0.99913542
78MP0001286_abnormal_eye_development0.99475294
79MP0002653_abnormal_ependyma_morphology0.98627397
80MP0003941_abnormal_skin_development0.97184511
81MP0005387_immune_system_phenotype0.95839057
82MP0001790_abnormal_immune_system0.95839057
83MP0008877_abnormal_DNA_methylation0.95319998
84MP0002938_white_spotting0.93591003
85MP0005666_abnormal_adipose_tissue0.92505298
86MP0003984_embryonic_growth_retardation0.91990918
87MP0002092_abnormal_eye_morphology0.90906136
88MP0002088_abnormal_embryonic_growth/wei0.90495094
89MP0005076_abnormal_cell_differentiation0.90215748
90MP0009053_abnormal_anal_canal0.89925809
91MP0002697_abnormal_eye_size0.87673247
92MP0010307_abnormal_tumor_latency0.86625361
93MP0002086_abnormal_extraembryonic_tissu0.85778217
94MP0005464_abnormal_platelet_physiology0.85463565
95MP0008995_early_reproductive_senescence0.84271778
96MP0009672_abnormal_birth_weight0.84241720
97MP0002085_abnormal_embryonic_tissue0.84194802
98MP0008789_abnormal_olfactory_epithelium0.83822581
99MP0000428_abnormal_craniofacial_morphol0.80184115
100MP0005408_hypopigmentation0.80103728
101MP0009278_abnormal_bone_marrow0.79480767
102MP0001346_abnormal_lacrimal_gland0.79341537
103MP0002419_abnormal_innate_immunity0.79252704
104MP0004381_abnormal_hair_follicle0.79211559
105MP0005501_abnormal_skin_physiology0.79167133
106MP0005499_abnormal_olfactory_system0.79101750
107MP0005394_taste/olfaction_phenotype0.79101750
108MP0010030_abnormal_orbit_morphology0.78478345
109MP0004858_abnormal_nervous_system0.77111316
110MP0003942_abnormal_urinary_system0.75691668
111MP0001845_abnormal_inflammatory_respons0.75655399
112MP0005023_abnormal_wound_healing0.75529144
113MP0000477_abnormal_intestine_morphology0.74693510
114MP0004197_abnormal_fetal_growth/weight/0.74055651
115MP0001293_anophthalmia0.73638598
116MP0006035_abnormal_mitochondrial_morpho0.73560760
117MP0001348_abnormal_lacrimal_gland0.72713355
118MP0003959_abnormal_lean_body0.72125043
119MP0002210_abnormal_sex_determination0.71302820
120MP0000358_abnormal_cell_content/0.71248558
121MP0002084_abnormal_developmental_patter0.69077600
122MP0003724_increased_susceptibility_to0.69017753
123MP0004947_skin_inflammation0.65927762
124MP0003448_altered_tumor_morphology0.65747491
125MP0001216_abnormal_epidermal_layer0.61589407
126MP0001145_abnormal_male_reproductive0.61368748
127MP0006036_abnormal_mitochondrial_physio0.60719405
128MP0000537_abnormal_urethra_morphology0.60359173
129MP0000372_irregular_coat_pigmentation0.58600833
130MP0002277_abnormal_respiratory_mucosa0.58379876
131MP0001119_abnormal_female_reproductive0.55927335

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.13412367
2Abnormal number of erythroid precursors (HP:0012131)7.45323747
3Reticulocytopenia (HP:0001896)7.24748703
4Macrocytic anemia (HP:0001972)5.21771874
5Pallor (HP:0000980)4.95677747
6Thrombocytosis (HP:0001894)3.69482889
7Aplastic anemia (HP:0001915)3.65281618
8Colon cancer (HP:0003003)3.45422521
911 pairs of ribs (HP:0000878)3.30539924
10Oral leukoplakia (HP:0002745)3.18742868
11Birth length less than 3rd percentile (HP:0003561)3.15994229
12Deep palmar crease (HP:0006191)3.12072837
13IgM deficiency (HP:0002850)3.09830750
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02901023
15Absent thumb (HP:0009777)2.81212863
16Abnormality of the parietal bone (HP:0002696)2.78765364
17Agammaglobulinemia (HP:0004432)2.76597419
18Colitis (HP:0002583)2.74861069
19Partial duplication of thumb phalanx (HP:0009944)2.73560052
20Seborrheic dermatitis (HP:0001051)2.66556728
21Multiple enchondromatosis (HP:0005701)2.65339056
22Rough bone trabeculation (HP:0100670)2.64723602
23Carpal bone hypoplasia (HP:0001498)2.63575867
24Breast hypoplasia (HP:0003187)2.58029304
25Microvesicular hepatic steatosis (HP:0001414)2.55313801
26Partial duplication of the phalanx of hand (HP:0009999)2.53677849
27Broad distal phalanx of finger (HP:0009836)2.52118345
28Selective tooth agenesis (HP:0001592)2.48423881
29Congenital, generalized hypertrichosis (HP:0004540)2.48237814
30Trismus (HP:0000211)2.46242750
31Abnormality of the fingertips (HP:0001211)2.42595153
32Abnormality of reticulocytes (HP:0004312)2.41862058
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39609037
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39609037
35Microretrognathia (HP:0000308)2.36781721
36Petechiae (HP:0000967)2.35135378
37Increased hepatocellular lipid droplets (HP:0006565)2.35112513
38Elevated erythrocyte sedimentation rate (HP:0003565)2.34246431
39Myelodysplasia (HP:0002863)2.29032800
40Truncus arteriosus (HP:0001660)2.28954604
41Exertional dyspnea (HP:0002875)2.27782958
42Depressed nasal ridge (HP:0000457)2.27577285
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23576059
44Patellar aplasia (HP:0006443)2.23198590
45Chronic otitis media (HP:0000389)2.20839298
46Type I transferrin isoform profile (HP:0003642)2.19662888
47Villous atrophy (HP:0011473)2.18307569
48Abnormality of small intestinal villus morphology (HP:0011472)2.18307569
49Premature graying of hair (HP:0002216)2.16195362
50Stenosis of the external auditory canal (HP:0000402)2.13888211
51Gastrointestinal inflammation (HP:0004386)2.13584341
52Lymphoma (HP:0002665)2.13513083
53Aplasia/Hypoplasia of the patella (HP:0006498)2.13370428
54Hyperthyroidism (HP:0000836)2.12232335
55Mitochondrial inheritance (HP:0001427)2.10850996
56Abnormality of the preputium (HP:0100587)2.08940383
57Hepatocellular necrosis (HP:0001404)2.08701511
58Increased IgE level (HP:0003212)2.07482728
59Cellular immunodeficiency (HP:0005374)2.06112286
60Asplenia (HP:0001746)2.03443699
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02494256
62Neoplasm of the pancreas (HP:0002894)2.02430793
63Hypertensive crisis (HP:0100735)2.01750048
64Hypoplasia of the radius (HP:0002984)2.01432863
65Degeneration of anterior horn cells (HP:0002398)2.01386186
66Abnormality of the anterior horn cell (HP:0006802)2.01386186
67Eczematoid dermatitis (HP:0000976)2.00748632
68Respiratory difficulties (HP:0002880)2.00154513
69Lipid accumulation in hepatocytes (HP:0006561)1.99929437
70Cleft eyelid (HP:0000625)1.99783546
71IgG deficiency (HP:0004315)1.99295912
72Chronic obstructive pulmonary disease (HP:0006510)1.99172824
73Obstructive lung disease (HP:0006536)1.99172824
74Triphalangeal thumb (HP:0001199)1.99148460
75Abnormality of T cell physiology (HP:0011840)1.98706046
76Diastasis recti (HP:0001540)1.98429868
77Abnormality of T cells (HP:0002843)1.98276061
78Pancytopenia (HP:0001876)1.96159525
79Chromsome breakage (HP:0040012)1.96021168
80High anterior hairline (HP:0009890)1.96018504
81Abnormal number of incisors (HP:0011064)1.95896108
82Recurrent bronchitis (HP:0002837)1.95499169
833-Methylglutaconic aciduria (HP:0003535)1.94826857
84Glossoptosis (HP:0000162)1.93552830
85Viral hepatitis (HP:0006562)1.93494325
86Poikiloderma (HP:0001029)1.93466940
87Meckel diverticulum (HP:0002245)1.92421766
88Septo-optic dysplasia (HP:0100842)1.91884361
89Muscle fiber atrophy (HP:0100295)1.91298602
90Abnormal hemoglobin (HP:0011902)1.90348098
91Gastrointestinal stroma tumor (HP:0100723)1.89863717
92Thick lower lip vermilion (HP:0000179)1.88960657
93Increased CSF lactate (HP:0002490)1.88958197
94Basal cell carcinoma (HP:0002671)1.88722487
95Acute necrotizing encephalopathy (HP:0006965)1.88329048
96Sparse eyelashes (HP:0000653)1.88151757
97Duplication of thumb phalanx (HP:0009942)1.87788013
98Nasolacrimal duct obstruction (HP:0000579)1.86776955
99Abnormal trabecular bone morphology (HP:0100671)1.86748231
100Agnosia (HP:0010524)1.86527072
101Acute lymphatic leukemia (HP:0006721)1.86322911
102Bone marrow hypocellularity (HP:0005528)1.86153713
103Aplasia/Hypoplasia of the spleen (HP:0010451)1.86129260
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.84542656
105Abnormality of the ileum (HP:0001549)1.84506138
106Granulocytopenia (HP:0001913)1.83902957
107Increased serum lactate (HP:0002151)1.82995067
108Inflammation of the large intestine (HP:0002037)1.82584271
109Lymphopenia (HP:0001888)1.81991862
110Panhypogammaglobulinemia (HP:0003139)1.80777086
111Abnormality of the heme biosynthetic pathway (HP:0010472)1.80755584
112Hepatic necrosis (HP:0002605)1.80384605
113Missing ribs (HP:0000921)1.79380849
114Migraine (HP:0002076)1.79236695
115Progressive muscle weakness (HP:0003323)1.78808196
116Maternal diabetes (HP:0009800)1.77975933
117Disproportionate tall stature (HP:0001519)1.76884755
118Increased intramyocellular lipid droplets (HP:0012240)1.76704602
119Cellulitis (HP:0100658)1.76589077
120Recurrent viral infections (HP:0004429)1.74845592
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.74305711
122Supernumerary ribs (HP:0005815)1.71789516
123Abnormality of chromosome stability (HP:0003220)1.71430942
124Optic nerve coloboma (HP:0000588)1.71146893
125Metaphyseal cupping (HP:0003021)1.70805747
126Tracheoesophageal fistula (HP:0002575)1.70653320
127Horseshoe kidney (HP:0000085)1.70374457
128Amaurosis fugax (HP:0100576)1.69734611
129Neonatal hypoglycemia (HP:0001998)1.69661305
130Atresia of the external auditory canal (HP:0000413)1.69642968
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.69261899
132Pustule (HP:0200039)1.68259825
133Abnormality of the thymus (HP:0000777)1.68217671
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67401763
135Abnormal mitochondria in muscle tissue (HP:0008316)1.67367329
136Overlapping toe (HP:0001845)1.66563200
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65624148
138Premature ovarian failure (HP:0008209)1.65460735
139Type 2 muscle fiber atrophy (HP:0003554)1.64675724
140Hypoparathyroidism (HP:0000829)1.63637211
141Cerebral hypomyelination (HP:0006808)1.63597095
142T lymphocytopenia (HP:0005403)1.63407522
143Thoracic kyphosis (HP:0002942)1.63024204
144Poor head control (HP:0002421)1.62470642
145Abnormality of the thoracic spine (HP:0100711)1.59055710
146Meningitis (HP:0001287)1.58955750
147Verrucae (HP:0200043)1.57878669
148Papilloma (HP:0012740)1.57878669
149Increased muscle lipid content (HP:0009058)1.55669231
150Premature skin wrinkling (HP:0100678)1.55591246
151Reticulocytosis (HP:0001923)1.51473184
152Abnormality of the aortic arch (HP:0012303)1.51260269
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.50992934
154Abnormality of cochlea (HP:0000375)1.47167494
155Abnormality of the lacrimal duct (HP:0011481)1.45427567
156Progressive external ophthalmoplegia (HP:0000590)1.45364579
157Supernumerary bones of the axial skeleton (HP:0009144)1.44550616
158Abnormality of DNA repair (HP:0003254)1.42855210
159Rib fusion (HP:0000902)1.42701668
160Rectal prolapse (HP:0002035)1.42507459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.13392625
2BUB13.98823552
3WEE13.77137141
4SMG13.31272963
5TRIB33.18822944
6PRPF4B3.07124626
7VRK23.03078784
8STK162.86959347
9CDC72.48722465
10EIF2AK12.43742375
11RPS6KB22.32402158
12MAP4K12.29726609
13SRPK12.22796852
14VRK12.13442798
15TGFBR12.00599273
16PIM21.96649771
17ACVR1B1.90586030
18EEF2K1.89027675
19TSSK61.88010052
20ICK1.83910900
21EIF2AK31.82426622
22PASK1.75850086
23DYRK31.72989792
24NEK21.72919831
25RIPK41.70903339
26PLK41.70882911
27TLK11.69572183
28KDR1.65326231
29BRSK21.60655732
30CDK121.58491859
31RPS6KA41.56679883
32TESK21.51628932
33ERN11.49683393
34MST41.44215554
35MKNK11.43578142
36AURKB1.42349426
37CDK71.38302812
38STK101.32915190
39TEC1.30294397
40SIK11.28850671
41PLK11.28385969
42BTK1.27117910
43ATR1.19849826
44TYRO31.17578793
45KIT1.13289391
46FGFR41.10787893
47BRAF1.10616983
48PIM11.09904308
49TTK1.09877588
50MAP2K21.08529053
51FLT31.08317298
52PAK41.06813109
53MAPKAPK31.02570168
54TXK0.98398059
55BLK0.97538737
56TYK20.96569684
57CDK40.95745962
58ILK0.94939467
59MAP3K80.94304475
60ZAP700.92320116
61EPHA20.91810881
62MAP3K130.91582684
63IRAK40.91110729
64MAP3K100.89618533
65MARK20.88755463
66TAF10.87194149
67STK40.86728359
68IRAK30.85757399
69NME10.83622228
70IKBKB0.83144957
71BRSK10.82171044
72MAP2K30.80708825
73CDK80.80681516
74AURKA0.80657777
75PTK60.79212150
76DYRK1B0.78327117
77EPHB20.78025513
78KSR20.77786330
79ARAF0.76289844
80IRAK20.76275587
81NEK10.76138444
82JAK30.76043471
83ZAK0.75385590
84MKNK20.75267670
85SCYL20.75030005
86* LRRK20.74784052
87PLK30.74352289
88EIF2AK20.74304990
89CSF1R0.73679829
90HIPK20.71706728
91GRK60.71564530
92MARK30.70984872
93MTOR0.70949124
94CSNK2A20.70609668
95CLK10.69064933
96CHEK20.68210924
97CSNK2A10.68097951
98CHEK10.68004547
99SYK0.67482094
100MAP3K30.67350013
101NLK0.67054228
102MAP3K70.65704200
103FES0.65171325
104TESK10.64024592
105CAMK1D0.62976669
106MAP3K110.62437408
107RPS6KA50.60615433
108CCNB10.59092389
109ITK0.58843700
110LYN0.58588408
111TBK10.56565477
112FGFR20.55892536
113BRD40.55503158
114MAPK150.54989694
115PAK10.52686130
116SIK20.52318770
117STK240.51847459
118LCK0.51356576
119CDK190.50253748
120PBK0.49090787
121IKBKE0.47433542
122FGFR30.47367086
123RAF10.45243917
124DYRK20.45173067
125ATM0.44124262
126TNK20.43424369
127TGFBR20.43048204
128CDK20.42504063
129CSK0.42017324
130PRKCI0.41257488
131DAPK30.41212577
132PKN20.40867961
133MYLK0.39491774
134RPS6KA10.39297428
135BMX0.39136883
136HCK0.39032056
137RPS6KA60.38119012
138ALK0.37722460
139MATK0.35380757
140MAPK110.35157417
141CDK60.35076392
142RPS6KC10.34970620
143RPS6KL10.34970620

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.38305710
2DNA replication_Homo sapiens_hsa030304.27885215
3Proteasome_Homo sapiens_hsa030503.67377401
4Mismatch repair_Homo sapiens_hsa034303.58118228
5RNA polymerase_Homo sapiens_hsa030203.31218130
6Spliceosome_Homo sapiens_hsa030403.08230264
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87841349
8Base excision repair_Homo sapiens_hsa034102.63339250
9Homologous recombination_Homo sapiens_hsa034402.60303894
10Nucleotide excision repair_Homo sapiens_hsa034202.53894563
11Pyrimidine metabolism_Homo sapiens_hsa002402.45320443
12RNA transport_Homo sapiens_hsa030132.33091166
13Cell cycle_Homo sapiens_hsa041101.83877225
14Non-homologous end-joining_Homo sapiens_hsa034501.80462186
15One carbon pool by folate_Homo sapiens_hsa006701.76814541
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70366908
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67992586
18Fanconi anemia pathway_Homo sapiens_hsa034601.66763575
19RNA degradation_Homo sapiens_hsa030181.65544790
20Basal transcription factors_Homo sapiens_hsa030221.52478062
21Primary immunodeficiency_Homo sapiens_hsa053401.52404747
22Protein export_Homo sapiens_hsa030601.45253181
23Parkinsons disease_Homo sapiens_hsa050121.38509267
24p53 signaling pathway_Homo sapiens_hsa041151.37696507
25Non-small cell lung cancer_Homo sapiens_hsa052231.35354599
26Oxidative phosphorylation_Homo sapiens_hsa001901.28195586
27Antigen processing and presentation_Homo sapiens_hsa046121.27191976
28Purine metabolism_Homo sapiens_hsa002301.21821501
29Epstein-Barr virus infection_Homo sapiens_hsa051691.20088233
30Huntingtons disease_Homo sapiens_hsa050161.17763362
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14090053
32Herpes simplex infection_Homo sapiens_hsa051681.07300305
33mRNA surveillance pathway_Homo sapiens_hsa030151.04888695
34Pancreatic cancer_Homo sapiens_hsa052121.02538001
35VEGF signaling pathway_Homo sapiens_hsa043700.99973293
36Endometrial cancer_Homo sapiens_hsa052130.92708158
37Systemic lupus erythematosus_Homo sapiens_hsa053220.89620154
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87661765
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80863994
40Hematopoietic cell lineage_Homo sapiens_hsa046400.80076923
41Renal cell carcinoma_Homo sapiens_hsa052110.79996252
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78504097
43Pentose phosphate pathway_Homo sapiens_hsa000300.77915971
44Measles_Homo sapiens_hsa051620.75939380
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.75891589
46mTOR signaling pathway_Homo sapiens_hsa041500.74627861
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.74302373
48Prostate cancer_Homo sapiens_hsa052150.72931065
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72343723
50Viral carcinogenesis_Homo sapiens_hsa052030.71853040
51Alzheimers disease_Homo sapiens_hsa050100.71255921
52Legionellosis_Homo sapiens_hsa051340.70170107
53Folate biosynthesis_Homo sapiens_hsa007900.69418849
54HTLV-I infection_Homo sapiens_hsa051660.66738466
55Bladder cancer_Homo sapiens_hsa052190.64348053
56Sulfur relay system_Homo sapiens_hsa041220.63641968
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.62635319
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.61962876
59ErbB signaling pathway_Homo sapiens_hsa040120.61379820
60Allograft rejection_Homo sapiens_hsa053300.61339232
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60528969
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60443607
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57332134
64Apoptosis_Homo sapiens_hsa042100.57117537
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56984226
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55944809
67Glutathione metabolism_Homo sapiens_hsa004800.54704970
68Leishmaniasis_Homo sapiens_hsa051400.52798301
69Cardiac muscle contraction_Homo sapiens_hsa042600.52701733
70Small cell lung cancer_Homo sapiens_hsa052220.52133965
71Graft-versus-host disease_Homo sapiens_hsa053320.51232517
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.50767766
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50764651
74Thyroid cancer_Homo sapiens_hsa052160.50478765
75N-Glycan biosynthesis_Homo sapiens_hsa005100.49381423
76Shigellosis_Homo sapiens_hsa051310.49326717
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.49025212
78Alcoholism_Homo sapiens_hsa050340.48175646
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47587662
80Wnt signaling pathway_Homo sapiens_hsa043100.46154868
81Hedgehog signaling pathway_Homo sapiens_hsa043400.45088725
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43926825
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43101951
84Carbon metabolism_Homo sapiens_hsa012000.42533021
85Hepatitis B_Homo sapiens_hsa051610.41767164
86Asthma_Homo sapiens_hsa053100.40834568
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40700644
88Choline metabolism in cancer_Homo sapiens_hsa052310.39885676
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39813405
90B cell receptor signaling pathway_Homo sapiens_hsa046620.39728292
91Osteoclast differentiation_Homo sapiens_hsa043800.38981605
92Influenza A_Homo sapiens_hsa051640.38858644
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.38762838
94Fructose and mannose metabolism_Homo sapiens_hsa000510.38754106
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38372920
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38175382
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38026975
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37113770
99Viral myocarditis_Homo sapiens_hsa054160.36521523
100Acute myeloid leukemia_Homo sapiens_hsa052210.36512435
101T cell receptor signaling pathway_Homo sapiens_hsa046600.36263193
102Prolactin signaling pathway_Homo sapiens_hsa049170.36205031
103FoxO signaling pathway_Homo sapiens_hsa040680.35615822
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34335455
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.33961986
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33388018
107Notch signaling pathway_Homo sapiens_hsa043300.32165281
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.30421772
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30414915
110Insulin signaling pathway_Homo sapiens_hsa049100.29949574
111Arachidonic acid metabolism_Homo sapiens_hsa005900.29181913
112Other glycan degradation_Homo sapiens_hsa005110.28241571
113MicroRNAs in cancer_Homo sapiens_hsa052060.27211444
114Toxoplasmosis_Homo sapiens_hsa051450.27025763
115HIF-1 signaling pathway_Homo sapiens_hsa040660.26476563
116Autoimmune thyroid disease_Homo sapiens_hsa053200.25295528
117Oocyte meiosis_Homo sapiens_hsa041140.25177540
118Colorectal cancer_Homo sapiens_hsa052100.23819870
119Pathways in cancer_Homo sapiens_hsa052000.22532342
120Metabolic pathways_Homo sapiens_hsa011000.22179664
121Pertussis_Homo sapiens_hsa051330.20328018
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19993356
123Chronic myeloid leukemia_Homo sapiens_hsa052200.19187859
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19112372
125Biosynthesis of amino acids_Homo sapiens_hsa012300.19106380
126TGF-beta signaling pathway_Homo sapiens_hsa043500.18659317
127Basal cell carcinoma_Homo sapiens_hsa052170.17534271
128Galactose metabolism_Homo sapiens_hsa000520.17483010
129Selenocompound metabolism_Homo sapiens_hsa004500.17446052
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16763157
131Malaria_Homo sapiens_hsa051440.16033821

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