RPS11P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.55525720
2cytidine metabolic process (GO:0046087)5.29108896
3cytidine catabolic process (GO:0006216)5.29108896
4cytidine deamination (GO:0009972)5.29108896
5ribosomal small subunit assembly (GO:0000028)4.94786018
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.91273675
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.77673714
8ATP synthesis coupled proton transport (GO:0015986)4.77673714
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.64835432
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62217601
11protein neddylation (GO:0045116)4.18530918
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.09500242
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.09500242
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08154107
15protein complex biogenesis (GO:0070271)3.96634040
16respiratory chain complex IV assembly (GO:0008535)3.86673816
17cytochrome complex assembly (GO:0017004)3.84006834
18respiratory electron transport chain (GO:0022904)3.72724177
19electron transport chain (GO:0022900)3.71927798
20behavioral response to nicotine (GO:0035095)3.70468077
21water-soluble vitamin biosynthetic process (GO:0042364)3.65479725
22maturation of SSU-rRNA (GO:0030490)3.64393104
23mitochondrial respiratory chain complex assembly (GO:0033108)3.54068261
24platelet dense granule organization (GO:0060155)3.44119671
25viral transcription (GO:0019083)3.40773710
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31915715
27translational termination (GO:0006415)3.31400552
28negative regulation of telomere maintenance (GO:0032205)3.24122013
29chaperone-mediated protein transport (GO:0072321)3.23761364
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23708051
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.20401477
32NADH dehydrogenase complex assembly (GO:0010257)3.20401477
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20401477
34cotranslational protein targeting to membrane (GO:0006613)3.20038869
35protein targeting to ER (GO:0045047)3.17036583
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16160419
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.16071683
38translational elongation (GO:0006414)3.11906187
39proteasome assembly (GO:0043248)3.01629443
40pseudouridine synthesis (GO:0001522)3.01017305
41response to pheromone (GO:0019236)3.00761415
42protein localization to endoplasmic reticulum (GO:0070972)3.00653580
43negative regulation by host of viral transcription (GO:0043922)3.00538267
44indolalkylamine metabolic process (GO:0006586)3.00430349
45rRNA catabolic process (GO:0016075)2.99414781
46establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99172913
47rRNA modification (GO:0000154)2.94675949
48positive thymic T cell selection (GO:0045059)2.94641871
49tryptophan metabolic process (GO:0006568)2.92595863
50mannosylation (GO:0097502)2.90969979
51indole-containing compound catabolic process (GO:0042436)2.90093614
52indolalkylamine catabolic process (GO:0046218)2.90093614
53tryptophan catabolic process (GO:0006569)2.90093614
54positive regulation of defense response to virus by host (GO:0002230)2.89546848
55positive T cell selection (GO:0043368)2.89363159
56hydrogen ion transmembrane transport (GO:1902600)2.88785659
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88270559
58translation (GO:0006412)2.87113957
59kynurenine metabolic process (GO:0070189)2.84364189
60termination of RNA polymerase III transcription (GO:0006386)2.83912623
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.83912623
62S-adenosylmethionine metabolic process (GO:0046500)2.83197207
63cellular ketone body metabolic process (GO:0046950)2.83167126
64regulation of cellular amino acid metabolic process (GO:0006521)2.78017518
65proton transport (GO:0015992)2.77720037
66ATP biosynthetic process (GO:0006754)2.75431725
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71809711
68ubiquinone biosynthetic process (GO:0006744)2.71089810
69hydrogen transport (GO:0006818)2.70837028
70ketone body metabolic process (GO:1902224)2.70437314
71GPI anchor metabolic process (GO:0006505)2.69421907
72positive regulation of prostaglandin secretion (GO:0032308)2.66457345
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65301635
74metallo-sulfur cluster assembly (GO:0031163)2.64736569
75iron-sulfur cluster assembly (GO:0016226)2.64736569
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64459135
77ribosomal small subunit biogenesis (GO:0042274)2.64310579
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62595605
79piRNA metabolic process (GO:0034587)2.62041596
80DNA demethylation (GO:0080111)2.61046723
81negative regulation of mast cell activation (GO:0033004)2.60322237
82GPI anchor biosynthetic process (GO:0006506)2.59163693
83fucose catabolic process (GO:0019317)2.55508511
84L-fucose metabolic process (GO:0042354)2.55508511
85L-fucose catabolic process (GO:0042355)2.55508511
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53869156
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53869156
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53869156
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53141429
90preassembly of GPI anchor in ER membrane (GO:0016254)2.53000314
91actin nucleation (GO:0045010)2.52397289
92adaptation of signaling pathway (GO:0023058)2.51711168
93positive regulation of T cell apoptotic process (GO:0070234)2.50594545
94aldehyde catabolic process (GO:0046185)2.50401982
95detection of light stimulus involved in sensory perception (GO:0050962)2.50039811
96detection of light stimulus involved in visual perception (GO:0050908)2.50039811
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49525320
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49525320
99response to interferon-beta (GO:0035456)2.49156618
100axoneme assembly (GO:0035082)2.47854431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.81529745
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65890291
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53761367
4VDR_22108803_ChIP-Seq_LS180_Human3.36828136
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.15728636
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97310723
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92455788
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89698860
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.86165615
10ZNF274_21170338_ChIP-Seq_K562_Hela2.82964844
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62434456
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47003997
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40782593
14VDR_23849224_ChIP-Seq_CD4+_Human2.37746247
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.28775932
16ELK1_19687146_ChIP-ChIP_HELA_Human2.08211256
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07355707
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97645042
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96593998
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.91542962
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88692245
22FOXP3_21729870_ChIP-Seq_TREG_Human1.85283774
23IGF1R_20145208_ChIP-Seq_DFB_Human1.83462437
24EZH2_22144423_ChIP-Seq_EOC_Human1.83236191
25MYC_18940864_ChIP-ChIP_HL60_Human1.77372931
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73508914
27EWS_26573619_Chip-Seq_HEK293_Human1.72057672
28TP53_22573176_ChIP-Seq_HFKS_Human1.71977031
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.70746500
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70387905
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.64529420
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59221952
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53719750
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49401156
35FUS_26573619_Chip-Seq_HEK293_Human1.43647426
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42237177
37AR_20517297_ChIP-Seq_VCAP_Human1.40959482
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37037548
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36991706
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33776576
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33480413
42P300_19829295_ChIP-Seq_ESCs_Human1.33103450
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.32722013
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32722013
45SOX2_19829295_ChIP-Seq_ESCs_Human1.30642230
46NANOG_19829295_ChIP-Seq_ESCs_Human1.30642230
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28054159
48GATA3_26560356_Chip-Seq_TH2_Human1.27880337
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.27047634
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24816696
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21817585
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21662362
53NCOR_22424771_ChIP-Seq_293T_Human1.21630311
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21203991
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20612210
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20285159
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20146086
58NANOG_20526341_ChIP-Seq_ESCs_Human1.20044318
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18682195
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18469106
61TAF2_19829295_ChIP-Seq_ESCs_Human1.18378651
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18038202
63IRF1_19129219_ChIP-ChIP_H3396_Human1.16379370
64BCAT_22108803_ChIP-Seq_LS180_Human1.16323555
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.15299086
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14202122
67ER_23166858_ChIP-Seq_MCF-7_Human1.13337265
68TAF15_26573619_Chip-Seq_HEK293_Human1.13092498
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10796594
70CBP_20019798_ChIP-Seq_JUKART_Human1.10796594
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07519588
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06151245
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05877332
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05160773
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03681202
76ERA_21632823_ChIP-Seq_H3396_Human1.01741020
77MYC_19829295_ChIP-Seq_ESCs_Human1.00388002
78IRF8_21731497_ChIP-ChIP_J774_Mouse0.99631544
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.98515827
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98316981
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.98157365
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98018195
83HOXB7_26014856_ChIP-Seq_BT474_Human0.97610840
84KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97125846
85RBPJ_21746931_ChIP-Seq_IB4_Human0.96791431
86HTT_18923047_ChIP-ChIP_STHdh_Human0.96093801
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95672434
88ERG_20517297_ChIP-Seq_VCAP_Human0.95157425
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.94695815
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94362470
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94036015
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94022998
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.93433433
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92896623
95TTF2_22483619_ChIP-Seq_HELA_Human0.91781473
96TCF4_22108803_ChIP-Seq_LS180_Human0.91144659
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90757170
98P53_21459846_ChIP-Seq_SAOS-2_Human0.90563703
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90368214
100GABP_19822575_ChIP-Seq_HepG2_Human0.89136380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.27262127
2MP0002102_abnormal_ear_morphology3.18436242
3MP0009379_abnormal_foot_pigmentation2.98486068
4MP0008877_abnormal_DNA_methylation2.59998850
5MP0006292_abnormal_olfactory_placode2.51511273
6MP0006072_abnormal_retinal_apoptosis2.47004965
7MP0000372_irregular_coat_pigmentation2.41666044
8MP0005377_hearing/vestibular/ear_phenot2.21980571
9MP0003878_abnormal_ear_physiology2.21980571
10MP0003195_calcinosis2.03249265
11MP0001835_abnormal_antigen_presentation1.95203616
12MP0005645_abnormal_hypothalamus_physiol1.94172642
13MP0008875_abnormal_xenobiotic_pharmacok1.92084877
14MP0001968_abnormal_touch/_nociception1.91598914
15MP0005551_abnormal_eye_electrophysiolog1.91036796
16MP0005084_abnormal_gallbladder_morpholo1.85263890
17MP0005646_abnormal_pituitary_gland1.79181335
18MP0006276_abnormal_autonomic_nervous1.79138556
19MP0002138_abnormal_hepatobiliary_system1.77015694
20MP0003646_muscle_fatigue1.74631810
21MP0004147_increased_porphyrin_level1.71986752
22MP0008872_abnormal_physiological_respon1.70516916
23MP0002837_dystrophic_cardiac_calcinosis1.70305137
24MP0002736_abnormal_nociception_after1.69597496
25MP0002876_abnormal_thyroid_physiology1.62430898
26MP0009785_altered_susceptibility_to1.56057429
27MP0003787_abnormal_imprinting1.55478674
28MP0005253_abnormal_eye_physiology1.54090154
29MP0002638_abnormal_pupillary_reflex1.52108089
30MP0001529_abnormal_vocalization1.48267560
31MP0004142_abnormal_muscle_tone1.48114199
32MP0003786_premature_aging1.47241204
33MP0001905_abnormal_dopamine_level1.45735771
34MP0009333_abnormal_splenocyte_physiolog1.45212853
35MP0002148_abnormal_hypersensitivity_rea1.42177228
36MP0002234_abnormal_pharynx_morphology1.42052976
37MP0002163_abnormal_gland_morphology1.39045688
38MP0005389_reproductive_system_phenotype1.37422241
39MP0003880_abnormal_central_pattern1.35930470
40MP0008995_early_reproductive_senescence1.31327506
41MP0001485_abnormal_pinna_reflex1.29613324
42MP0005075_abnormal_melanosome_morpholog1.25946717
43MP0001919_abnormal_reproductive_system1.25259101
44MP0002160_abnormal_reproductive_system1.25220648
45MP0003283_abnormal_digestive_organ1.22955075
46MP0008789_abnormal_olfactory_epithelium1.22432390
47MP0004885_abnormal_endolymph1.21596517
48MP0004145_abnormal_muscle_electrophysio1.21307854
49MP0003011_delayed_dark_adaptation1.19619577
50MP0001984_abnormal_olfaction1.18836094
51MP0001800_abnormal_humoral_immune1.17187401
52MP0003806_abnormal_nucleotide_metabolis1.12357605
53MP0003866_abnormal_defecation1.12100574
54MP0001764_abnormal_homeostasis1.10830524
55MP0001873_stomach_inflammation1.10226991
56MP0001986_abnormal_taste_sensitivity1.08865220
57MP0003186_abnormal_redox_activity1.08392449
58MP0006036_abnormal_mitochondrial_physio1.07938639
59MP0002277_abnormal_respiratory_mucosa1.07597393
60MP0003763_abnormal_thymus_physiology1.05895309
61MP0005000_abnormal_immune_tolerance1.05200428
62MP0002723_abnormal_immune_serum1.04792028
63MP0003252_abnormal_bile_duct1.03151580
64MP0009745_abnormal_behavioral_response1.00387780
65MP0002272_abnormal_nervous_system1.00292944
66MP0001790_abnormal_immune_system0.99607137
67MP0005387_immune_system_phenotype0.99607137
68MP0002095_abnormal_skin_pigmentation0.99015603
69MP0000631_abnormal_neuroendocrine_gland0.97525895
70MP0002166_altered_tumor_susceptibility0.96089913
71MP0005410_abnormal_fertilization0.94478553
72MP0002420_abnormal_adaptive_immunity0.94112531
73MP0001293_anophthalmia0.92169342
74MP0008058_abnormal_DNA_repair0.91213778
75MP0002653_abnormal_ependyma_morphology0.90767664
76MP0009764_decreased_sensitivity_to0.90573856
77MP0001819_abnormal_immune_cell0.90394969
78MP0004043_abnormal_pH_regulation0.87776178
79MP0005636_abnormal_mineral_homeostasis0.87691975
80MP0005379_endocrine/exocrine_gland_phen0.87001315
81MP0002006_tumorigenesis0.84182177
82MP0001501_abnormal_sleep_pattern0.83770389
83MP0002938_white_spotting0.83252881
84MP0005195_abnormal_posterior_eye0.82379899
85MP0003693_abnormal_embryo_hatching0.80981782
86MP0002733_abnormal_thermal_nociception0.80050450
87MP0001119_abnormal_female_reproductive0.79933773
88MP0001188_hyperpigmentation0.79556463
89MP0004924_abnormal_behavior0.79370130
90MP0005386_behavior/neurological_phenoty0.79370130
91MP0004742_abnormal_vestibular_system0.77929284
92MP0005332_abnormal_amino_acid0.76218380
93MP0000685_abnormal_immune_system0.73842974
94MP0002452_abnormal_antigen_presenting0.73494741
95MP0008775_abnormal_heart_ventricle0.72977606
96MP0001970_abnormal_pain_threshold0.72857491
97MP0005025_abnormal_response_to0.72690966
98MP0002693_abnormal_pancreas_physiology0.71303346
99MP0000716_abnormal_immune_system0.71280412
100MP0003718_maternal_effect0.71191532

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.39371204
2Mitochondrial inheritance (HP:0001427)4.10954534
3Abnormal mitochondria in muscle tissue (HP:0008316)3.99864274
4Progressive macrocephaly (HP:0004481)3.87840167
5Acute encephalopathy (HP:0006846)3.72065363
6Increased CSF lactate (HP:0002490)3.61134280
7Pancreatic cysts (HP:0001737)3.53054233
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.49822152
9Increased hepatocellular lipid droplets (HP:0006565)3.39026914
10Pancreatic fibrosis (HP:0100732)3.37165264
11Abnormal rod and cone electroretinograms (HP:0008323)3.30184399
12Hepatocellular necrosis (HP:0001404)3.23369500
13Lipid accumulation in hepatocytes (HP:0006561)3.20925961
14Congenital stationary night blindness (HP:0007642)3.11820060
15Renal Fanconi syndrome (HP:0001994)2.98799433
16Hepatic necrosis (HP:0002605)2.98513700
17Increased intramyocellular lipid droplets (HP:0012240)2.95908787
18True hermaphroditism (HP:0010459)2.93399255
193-Methylglutaconic aciduria (HP:0003535)2.91466679
20Cerebral edema (HP:0002181)2.90142474
21Abnormality of midbrain morphology (HP:0002418)2.88733727
22Molar tooth sign on MRI (HP:0002419)2.88733727
23IgG deficiency (HP:0004315)2.87623958
24Severe combined immunodeficiency (HP:0004430)2.87371003
25Elevated erythrocyte sedimentation rate (HP:0003565)2.86567758
26Thyroiditis (HP:0100646)2.83492431
27Methylmalonic acidemia (HP:0002912)2.82784582
28Aplastic anemia (HP:0001915)2.80873166
29Optic disc pallor (HP:0000543)2.76261691
30Type II lissencephaly (HP:0007260)2.63534684
31Abnormality of the renal cortex (HP:0011035)2.63164175
32Hypoproteinemia (HP:0003075)2.59333530
33Abolished electroretinogram (ERG) (HP:0000550)2.58336192
34Pendular nystagmus (HP:0012043)2.53723461
35Attenuation of retinal blood vessels (HP:0007843)2.51304654
36Absent thumb (HP:0009777)2.50489511
37Stomatitis (HP:0010280)2.46889962
38Increased muscle lipid content (HP:0009058)2.45342140
39Reticulocytopenia (HP:0001896)2.45183301
40Congenital, generalized hypertrichosis (HP:0004540)2.45043343
41Decreased central vision (HP:0007663)2.44218757
42Nephronophthisis (HP:0000090)2.38782044
43Methylmalonic aciduria (HP:0012120)2.38050099
44Renal cortical cysts (HP:0000803)2.36942803
45Exertional dyspnea (HP:0002875)2.36704206
46Hyperglycinemia (HP:0002154)2.35572371
47Increased serum lactate (HP:0002151)2.29479660
48Abnormality of cells of the erythroid lineage (HP:0012130)2.27485921
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26594553
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26594553
51Abnormality of B cell number (HP:0010975)2.25222140
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24854513
53Lactic acidosis (HP:0003128)2.20579060
54Polydipsia (HP:0001959)2.20471613
55Abnormal drinking behavior (HP:0030082)2.20471613
56Abnormal number of erythroid precursors (HP:0012131)2.19460681
57Cystic liver disease (HP:0006706)2.16152794
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.15753179
59Panhypogammaglobulinemia (HP:0003139)2.15413905
60Lethargy (HP:0001254)2.13624863
61Medial flaring of the eyebrow (HP:0010747)2.12778122
62Constricted visual fields (HP:0001133)2.12700439
63Abnormality of the renal medulla (HP:0100957)2.09996862
64Abnormality of the prostate (HP:0008775)2.07564685
65Asplenia (HP:0001746)2.06022361
66Abnormality of T cell number (HP:0011839)2.04483207
67Abnormality of renal resorption (HP:0011038)2.04299437
68Colon cancer (HP:0003003)2.03106263
69Abnormality of urine glucose concentration (HP:0011016)2.02751764
70Glycosuria (HP:0003076)2.02751764
71Combined immunodeficiency (HP:0005387)2.00275533
72Abnormality of DNA repair (HP:0003254)2.00225629
73Sclerocornea (HP:0000647)1.99269824
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98820125
75Ketosis (HP:0001946)1.96220277
76Pancytopenia (HP:0001876)1.95156017
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94736423
78Dicarboxylic aciduria (HP:0003215)1.94736423
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.93255400
80T lymphocytopenia (HP:0005403)1.92384280
81Keratoconus (HP:0000563)1.92332373
82Increased corneal curvature (HP:0100692)1.92332373
83Abnormality of T cells (HP:0002843)1.91887242
84Increased IgM level (HP:0003496)1.91542644
85B lymphocytopenia (HP:0010976)1.91268414
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91183976
87Respiratory failure (HP:0002878)1.91015630
88Type 2 muscle fiber atrophy (HP:0003554)1.88674909
89Abnormality of the pons (HP:0007361)1.85325097
90Exercise intolerance (HP:0003546)1.83149295
91Type I transferrin isoform profile (HP:0003642)1.82672963
92Macrocytic anemia (HP:0001972)1.82473998
93Tubular atrophy (HP:0000092)1.80712407
94Chronic mucocutaneous candidiasis (HP:0002728)1.80324845
95Recurrent cutaneous fungal infections (HP:0011370)1.80324845
96Hypoplasia of the pons (HP:0012110)1.79005009
97Generalized aminoaciduria (HP:0002909)1.77933835
98Leukodystrophy (HP:0002415)1.77512536
99Abnormality of eosinophils (HP:0001879)1.77305491
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.76482925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.35011911
2TXK3.34496302
3VRK23.10325105
4BCKDK3.04691767
5ZAK2.89585906
6MAP4K22.88551448
7KDR2.86606411
8ADRBK22.76032581
9BMPR1B2.66788482
10GRK12.50222802
11NUAK12.50049031
12TAOK32.22790629
13TLK12.08041960
14TESK21.80141068
15MAP3K91.64690734
16WNK41.64053204
17EIF2AK31.62796096
18VRK11.57637903
19MST41.50863502
20STK161.48046034
21TIE11.34821805
22PINK11.30722798
23WNK31.29225899
24TEC1.27279906
25PLK21.23290383
26TAF11.23053706
27PIK3CG1.21854057
28ITK1.15435024
29INSRR1.14986203
30EIF2AK11.13390664
31PRKCQ1.13098831
32GRK61.10142661
33MAP4K11.06802939
34CDK191.06557391
35KIT1.02507484
36TRIM280.99610202
37CAMKK20.98057000
38MAP3K120.96924815
39IKBKB0.95860687
40OXSR10.92195089
41DYRK20.91564575
42LIMK10.88951452
43MUSK0.88941557
44PASK0.88913050
45BUB10.87289423
46CDK80.85588952
47TGFBR10.85549004
48SYK0.82334937
49ADRBK10.80926941
50GRK70.78862730
51CSNK1G30.78300744
52ERBB30.77939949
53PLK30.76176054
54CSNK1G10.70976920
55STK390.69924374
56CSNK1G20.68536590
57DAPK20.68390442
58MAPK130.66814198
59LCK0.66445999
60PLK40.66443559
61TNIK0.66035181
62FES0.64966296
63NEK10.64159949
64NME10.63846520
65PIK3CA0.63149806
66ACVR1B0.59537178
67LRRK20.59215822
68PRKCE0.56903162
69DAPK30.53321385
70GRK50.52776400
71CASK0.51996346
72RPS6KA50.51518458
73MAPKAPK30.51509149
74DAPK10.50831258
75BTK0.49321957
76PLK10.49279242
77OBSCN0.48520187
78PRKCG0.47939607
79LYN0.46639066
80MAP2K60.46630845
81PAK30.46295425
82PRKACA0.44687238
83PRKCA0.44354005
84AURKA0.42624001
85CSNK2A20.42463094
86MAPKAPK50.41482409
87MYLK0.41443795
88CSNK1A1L0.40030432
89ATR0.38248703
90MAP3K40.38243551
91IKBKE0.37935929
92SRPK10.37778363
93FLT30.37403407
94PIM20.36383684
95CSNK1A10.36202401
96IGF1R0.35450783
97MKNK20.34978250
98CSNK2A10.34379171
99PRKCI0.33205332
100MKNK10.33046025

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.82561614
2Ribosome_Homo sapiens_hsa030103.59434720
3Proteasome_Homo sapiens_hsa030503.41206046
4Parkinsons disease_Homo sapiens_hsa050123.21012467
5Primary immunodeficiency_Homo sapiens_hsa053403.02385298
6Protein export_Homo sapiens_hsa030602.41342899
7RNA polymerase_Homo sapiens_hsa030202.22172675
8Allograft rejection_Homo sapiens_hsa053302.21303488
9Asthma_Homo sapiens_hsa053102.21295100
10Autoimmune thyroid disease_Homo sapiens_hsa053202.16793372
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11075344
12Alzheimers disease_Homo sapiens_hsa050102.05284252
13Huntingtons disease_Homo sapiens_hsa050162.00348845
14Graft-versus-host disease_Homo sapiens_hsa053321.98217906
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92387178
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91589556
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.89414492
18Phototransduction_Homo sapiens_hsa047441.86019666
19Linoleic acid metabolism_Homo sapiens_hsa005911.81601516
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81166882
21Type I diabetes mellitus_Homo sapiens_hsa049401.78710824
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77510343
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68293370
24Cardiac muscle contraction_Homo sapiens_hsa042601.66425953
25Antigen processing and presentation_Homo sapiens_hsa046121.52287105
26Nitrogen metabolism_Homo sapiens_hsa009101.51754438
27Homologous recombination_Homo sapiens_hsa034401.50448204
28RNA degradation_Homo sapiens_hsa030181.47397368
29One carbon pool by folate_Homo sapiens_hsa006701.47224698
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39329642
31Fanconi anemia pathway_Homo sapiens_hsa034601.33928814
32Propanoate metabolism_Homo sapiens_hsa006401.33422935
33Butanoate metabolism_Homo sapiens_hsa006501.32906550
34Basal transcription factors_Homo sapiens_hsa030221.30997671
35Caffeine metabolism_Homo sapiens_hsa002321.24799822
36Peroxisome_Homo sapiens_hsa041461.20651203
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20314609
38Hematopoietic cell lineage_Homo sapiens_hsa046401.18502840
39Rheumatoid arthritis_Homo sapiens_hsa053231.17418799
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16505428
41Tryptophan metabolism_Homo sapiens_hsa003801.09486889
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00151339
43Arachidonic acid metabolism_Homo sapiens_hsa005900.99770306
44Pyrimidine metabolism_Homo sapiens_hsa002400.98762579
45Ether lipid metabolism_Homo sapiens_hsa005650.97340527
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.96559568
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.94423221
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93203192
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92880425
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85448512
51Chemical carcinogenesis_Homo sapiens_hsa052040.85050435
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80353054
53Selenocompound metabolism_Homo sapiens_hsa004500.80340928
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79272518
55Nucleotide excision repair_Homo sapiens_hsa034200.78932135
56Purine metabolism_Homo sapiens_hsa002300.78062845
57Olfactory transduction_Homo sapiens_hsa047400.76120196
58T cell receptor signaling pathway_Homo sapiens_hsa046600.74313594
59Collecting duct acid secretion_Homo sapiens_hsa049660.74114745
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72336651
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69968932
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68204559
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.66745095
64RNA transport_Homo sapiens_hsa030130.66624523
65Retinol metabolism_Homo sapiens_hsa008300.66106774
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65151800
67Metabolic pathways_Homo sapiens_hsa011000.64865964
68Regulation of autophagy_Homo sapiens_hsa041400.62304234
69Fat digestion and absorption_Homo sapiens_hsa049750.60899731
70Mismatch repair_Homo sapiens_hsa034300.59166200
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57919744
72Spliceosome_Homo sapiens_hsa030400.55420711
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54695407
74Sulfur metabolism_Homo sapiens_hsa009200.54620010
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53556934
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.52540464
77Nicotine addiction_Homo sapiens_hsa050330.51541957
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51339052
79Taste transduction_Homo sapiens_hsa047420.48419391
80Systemic lupus erythematosus_Homo sapiens_hsa053220.47354233
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46903774
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43546147
83Base excision repair_Homo sapiens_hsa034100.41301359
84Fatty acid degradation_Homo sapiens_hsa000710.38497108
85Viral myocarditis_Homo sapiens_hsa054160.36714659
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36023677
87Non-homologous end-joining_Homo sapiens_hsa034500.34880167
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33344651
89Mineral absorption_Homo sapiens_hsa049780.32725946
90Sulfur relay system_Homo sapiens_hsa041220.31798435
91Glutathione metabolism_Homo sapiens_hsa004800.28049702
92Measles_Homo sapiens_hsa051620.26511277
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25621641
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.25601247
95Morphine addiction_Homo sapiens_hsa050320.21717058
96beta-Alanine metabolism_Homo sapiens_hsa004100.20809734
97Staphylococcus aureus infection_Homo sapiens_hsa051500.20652183
98DNA replication_Homo sapiens_hsa030300.20360788
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19704650
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18327886

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