ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.55525720
2	cytidine deamination (GO:0009972)	5.29108896
3	cytidine metabolic process (GO:0046087)	5.29108896
4	cytidine catabolic process (GO:0006216)	5.29108896
5	ribosomal small subunit assembly (GO:0000028)	4.94786018
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.91273675
7	ATP synthesis coupled proton transport (GO:0015986)	4.77673714
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.77673714
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.64835432
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.62217601
11	protein neddylation (GO:0045116)	4.18530918
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.09500242
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.09500242
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.08154107
15	protein complex biogenesis (GO:0070271)	3.96634040
16	respiratory chain complex IV assembly (GO:0008535)	3.86673816
17	cytochrome complex assembly (GO:0017004)	3.84006834
18	respiratory electron transport chain (GO:0022904)	3.72724177
19	electron transport chain (GO:0022900)	3.71927798
20	behavioral response to nicotine (GO:0035095)	3.70468077
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.65479725
22	maturation of SSU-rRNA (GO:0030490)	3.64393104
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.54068261
24	platelet dense granule organization (GO:0060155)	3.44119671
25	viral transcription (GO:0019083)	3.40773710
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.31915715
27	translational termination (GO:0006415)	3.31400552
28	negative regulation of telomere maintenance (GO:0032205)	3.24122013
29	chaperone-mediated protein transport (GO:0072321)	3.23761364
30	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.23708051
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20401477
32	NADH dehydrogenase complex assembly (GO:0010257)	3.20401477
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20401477
34	cotranslational protein targeting to membrane (GO:0006613)	3.20038869
35	protein targeting to ER (GO:0045047)	3.17036583
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.16160419
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16071683
38	translational elongation (GO:0006414)	3.11906187
39	proteasome assembly (GO:0043248)	3.01629443
40	pseudouridine synthesis (GO:0001522)	3.01017305
41	response to pheromone (GO:0019236)	3.00761415
42	protein localization to endoplasmic reticulum (GO:0070972)	3.00653580
43	negative regulation by host of viral transcription (GO:0043922)	3.00538267
44	indolalkylamine metabolic process (GO:0006586)	3.00430349
45	rRNA catabolic process (GO:0016075)	2.99414781
46	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.99172913
47	rRNA modification (GO:0000154)	2.94675949
48	positive thymic T cell selection (GO:0045059)	2.94641871
49	tryptophan metabolic process (GO:0006568)	2.92595863
50	mannosylation (GO:0097502)	2.90969979
51	tryptophan catabolic process (GO:0006569)	2.90093614
52	indole-containing compound catabolic process (GO:0042436)	2.90093614
53	indolalkylamine catabolic process (GO:0046218)	2.90093614
54	positive regulation of defense response to virus by host (GO:0002230)	2.89546848
55	positive T cell selection (GO:0043368)	2.89363159
56	hydrogen ion transmembrane transport (GO:1902600)	2.88785659
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.88270559
58	translation (GO:0006412)	2.87113957
59	kynurenine metabolic process (GO:0070189)	2.84364189
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.83912623
61	termination of RNA polymerase III transcription (GO:0006386)	2.83912623
62	S-adenosylmethionine metabolic process (GO:0046500)	2.83197207
63	cellular ketone body metabolic process (GO:0046950)	2.83167126
64	regulation of cellular amino acid metabolic process (GO:0006521)	2.78017518
65	proton transport (GO:0015992)	2.77720037
66	ATP biosynthetic process (GO:0006754)	2.75431725
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71809711
68	ubiquinone biosynthetic process (GO:0006744)	2.71089810
69	hydrogen transport (GO:0006818)	2.70837028
70	ketone body metabolic process (GO:1902224)	2.70437314
71	GPI anchor metabolic process (GO:0006505)	2.69421907
72	positive regulation of prostaglandin secretion (GO:0032308)	2.66457345
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.65301635
74	iron-sulfur cluster assembly (GO:0016226)	2.64736569
75	metallo-sulfur cluster assembly (GO:0031163)	2.64736569
76	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64459135
77	ribosomal small subunit biogenesis (GO:0042274)	2.64310579
78	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.62595605
79	piRNA metabolic process (GO:0034587)	2.62041596
80	DNA demethylation (GO:0080111)	2.61046723
81	negative regulation of mast cell activation (GO:0033004)	2.60322237
82	GPI anchor biosynthetic process (GO:0006506)	2.59163693
83	L-fucose catabolic process (GO:0042355)	2.55508511
84	fucose catabolic process (GO:0019317)	2.55508511
85	L-fucose metabolic process (GO:0042354)	2.55508511
86	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.53869156
87	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.53869156
88	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.53869156
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.53141429
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.53000314
91	actin nucleation (GO:0045010)	2.52397289
92	adaptation of signaling pathway (GO:0023058)	2.51711168
93	positive regulation of T cell apoptotic process (GO:0070234)	2.50594545
94	aldehyde catabolic process (GO:0046185)	2.50401982
95	detection of light stimulus involved in sensory perception (GO:0050962)	2.50039811
96	detection of light stimulus involved in visual perception (GO:0050908)	2.50039811
97	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.49525320
98	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.49525320
99	response to interferon-beta (GO:0035456)	2.49156618
100	axoneme assembly (GO:0035082)	2.47854431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.81529745
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65890291
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.53761367
4	VDR_22108803_ChIP-Seq_LS180_Human	3.36828136
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.15728636
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97310723
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.92455788
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.89698860
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.86165615
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.82964844
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.62434456
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47003997
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40782593
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.37746247
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28775932
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08211256
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07355707
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97645042
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96593998
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.91542962
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.88692245
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85283774
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83462437
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.83236191
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.77372931
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73508914
27	EWS_26573619_Chip-Seq_HEK293_Human	1.72057672
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.71977031
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70746500
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.70387905
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64529420
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59221952
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.53719750
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49401156
35	FUS_26573619_Chip-Seq_HEK293_Human	1.43647426
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42237177
37	AR_20517297_ChIP-Seq_VCAP_Human	1.40959482
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37037548
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36991706
40	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.33776576
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.33480413
42	P300_19829295_ChIP-Seq_ESCs_Human	1.33103450
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32722013
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32722013
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30642230
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30642230
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28054159
48	GATA3_26560356_Chip-Seq_TH2_Human	1.27880337
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27047634
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24816696
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.21817585
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21662362
53	NCOR_22424771_ChIP-Seq_293T_Human	1.21630311
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21203991
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20612210
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20285159
57	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20146086
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20044318
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18682195
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18469106
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18378651
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18038202
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16379370
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.16323555
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15299086
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14202122
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.13337265
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.13092498
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.10796594
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10796594
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07519588
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06151245
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05877332
74	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05160773
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03681202
76	ERA_21632823_ChIP-Seq_H3396_Human	1.01741020
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.00388002
78	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.99631544
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98515827
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98316981
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98157365
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98018195
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97610840
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97125846
85	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96791431
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96093801
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95672434
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.95157425
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94695815
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94362470
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94036015
92	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94022998
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93433433
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92896623
95	TTF2_22483619_ChIP-Seq_HELA_Human	0.91781473
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.91144659
97	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90757170
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90563703
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90368214
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.89136380

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.27262127
2	MP0002102_abnormal_ear_morphology	3.18436242
3	MP0009379_abnormal_foot_pigmentation	2.98486068
4	MP0008877_abnormal_DNA_methylation	2.59998850
5	MP0006292_abnormal_olfactory_placode	2.51511273
6	MP0006072_abnormal_retinal_apoptosis	2.47004965
7	MP0000372_irregular_coat_pigmentation	2.41666044
8	MP0003878_abnormal_ear_physiology	2.21980571
9	MP0005377_hearing/vestibular/ear_phenot	2.21980571
10	MP0003195_calcinosis	2.03249265
11	MP0001835_abnormal_antigen_presentation	1.95203616
12	MP0005645_abnormal_hypothalamus_physiol	1.94172642
13	MP0008875_abnormal_xenobiotic_pharmacok	1.92084877
14	MP0001968_abnormal_touch/_nociception	1.91598914
15	MP0005551_abnormal_eye_electrophysiolog	1.91036796
16	MP0005084_abnormal_gallbladder_morpholo	1.85263890
17	MP0005646_abnormal_pituitary_gland	1.79181335
18	MP0006276_abnormal_autonomic_nervous	1.79138556
19	MP0002138_abnormal_hepatobiliary_system	1.77015694
20	MP0003646_muscle_fatigue	1.74631810
21	MP0004147_increased_porphyrin_level	1.71986752
22	MP0008872_abnormal_physiological_respon	1.70516916
23	MP0002837_dystrophic_cardiac_calcinosis	1.70305137
24	MP0002736_abnormal_nociception_after	1.69597496
25	MP0002876_abnormal_thyroid_physiology	1.62430898
26	MP0009785_altered_susceptibility_to	1.56057429
27	MP0003787_abnormal_imprinting	1.55478674
28	MP0005253_abnormal_eye_physiology	1.54090154
29	MP0002638_abnormal_pupillary_reflex	1.52108089
30	MP0001529_abnormal_vocalization	1.48267560
31	MP0004142_abnormal_muscle_tone	1.48114199
32	MP0003786_premature_aging	1.47241204
33	MP0001905_abnormal_dopamine_level	1.45735771
34	MP0009333_abnormal_splenocyte_physiolog	1.45212853
35	MP0002148_abnormal_hypersensitivity_rea	1.42177228
36	MP0002234_abnormal_pharynx_morphology	1.42052976
37	MP0002163_abnormal_gland_morphology	1.39045688
38	MP0005389_reproductive_system_phenotype	1.37422241
39	MP0003880_abnormal_central_pattern	1.35930470
40	MP0008995_early_reproductive_senescence	1.31327506
41	MP0001485_abnormal_pinna_reflex	1.29613324
42	MP0005075_abnormal_melanosome_morpholog	1.25946717
43	MP0001919_abnormal_reproductive_system	1.25259101
44	MP0002160_abnormal_reproductive_system	1.25220648
45	MP0003283_abnormal_digestive_organ	1.22955075
46	MP0008789_abnormal_olfactory_epithelium	1.22432390
47	MP0004885_abnormal_endolymph	1.21596517
48	MP0004145_abnormal_muscle_electrophysio	1.21307854
49	MP0003011_delayed_dark_adaptation	1.19619577
50	MP0001984_abnormal_olfaction	1.18836094
51	MP0001800_abnormal_humoral_immune	1.17187401
52	MP0003806_abnormal_nucleotide_metabolis	1.12357605
53	MP0003866_abnormal_defecation	1.12100574
54	MP0001764_abnormal_homeostasis	1.10830524
55	MP0001873_stomach_inflammation	1.10226991
56	MP0001986_abnormal_taste_sensitivity	1.08865220
57	MP0003186_abnormal_redox_activity	1.08392449
58	MP0006036_abnormal_mitochondrial_physio	1.07938639
59	MP0002277_abnormal_respiratory_mucosa	1.07597393
60	MP0003763_abnormal_thymus_physiology	1.05895309
61	MP0005000_abnormal_immune_tolerance	1.05200428
62	MP0002723_abnormal_immune_serum	1.04792028
63	MP0003252_abnormal_bile_duct	1.03151580
64	MP0009745_abnormal_behavioral_response	1.00387780
65	MP0002272_abnormal_nervous_system	1.00292944
66	MP0005387_immune_system_phenotype	0.99607137
67	MP0001790_abnormal_immune_system	0.99607137
68	MP0002095_abnormal_skin_pigmentation	0.99015603
69	MP0000631_abnormal_neuroendocrine_gland	0.97525895
70	MP0002166_altered_tumor_susceptibility	0.96089913
71	MP0005410_abnormal_fertilization	0.94478553
72	MP0002420_abnormal_adaptive_immunity	0.94112531
73	MP0001293_anophthalmia	0.92169342
74	MP0008058_abnormal_DNA_repair	0.91213778
75	MP0002653_abnormal_ependyma_morphology	0.90767664
76	MP0009764_decreased_sensitivity_to	0.90573856
77	MP0001819_abnormal_immune_cell	0.90394969
78	MP0004043_abnormal_pH_regulation	0.87776178
79	MP0005636_abnormal_mineral_homeostasis	0.87691975
80	MP0005379_endocrine/exocrine_gland_phen	0.87001315
81	MP0002006_tumorigenesis	0.84182177
82	MP0001501_abnormal_sleep_pattern	0.83770389
83	MP0002938_white_spotting	0.83252881
84	MP0005195_abnormal_posterior_eye	0.82379899
85	MP0003693_abnormal_embryo_hatching	0.80981782
86	MP0002733_abnormal_thermal_nociception	0.80050450
87	MP0001119_abnormal_female_reproductive	0.79933773
88	MP0001188_hyperpigmentation	0.79556463
89	MP0005386_behavior/neurological_phenoty	0.79370130
90	MP0004924_abnormal_behavior	0.79370130
91	MP0004742_abnormal_vestibular_system	0.77929284
92	MP0005332_abnormal_amino_acid	0.76218380
93	MP0000685_abnormal_immune_system	0.73842974
94	MP0002452_abnormal_antigen_presenting	0.73494741
95	MP0008775_abnormal_heart_ventricle	0.72977606
96	MP0001970_abnormal_pain_threshold	0.72857491
97	MP0005025_abnormal_response_to	0.72690966
98	MP0002693_abnormal_pancreas_physiology	0.71303346
99	MP0000716_abnormal_immune_system	0.71280412
100	MP0003718_maternal_effect	0.71191532

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.39371204
2	Mitochondrial inheritance (HP:0001427)	4.10954534
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.99864274
4	Progressive macrocephaly (HP:0004481)	3.87840167
5	Acute encephalopathy (HP:0006846)	3.72065363
6	Increased CSF lactate (HP:0002490)	3.61134280
7	Pancreatic cysts (HP:0001737)	3.53054233
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.49822152
9	Increased hepatocellular lipid droplets (HP:0006565)	3.39026914
10	Pancreatic fibrosis (HP:0100732)	3.37165264
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.30184399
12	Hepatocellular necrosis (HP:0001404)	3.23369500
13	Lipid accumulation in hepatocytes (HP:0006561)	3.20925961
14	Congenital stationary night blindness (HP:0007642)	3.11820060
15	Renal Fanconi syndrome (HP:0001994)	2.98799433
16	Hepatic necrosis (HP:0002605)	2.98513700
17	Increased intramyocellular lipid droplets (HP:0012240)	2.95908787
18	True hermaphroditism (HP:0010459)	2.93399255
19	3-Methylglutaconic aciduria (HP:0003535)	2.91466679
20	Cerebral edema (HP:0002181)	2.90142474
21	Abnormality of midbrain morphology (HP:0002418)	2.88733727
22	Molar tooth sign on MRI (HP:0002419)	2.88733727
23	IgG deficiency (HP:0004315)	2.87623958
24	Severe combined immunodeficiency (HP:0004430)	2.87371003
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86567758
26	Thyroiditis (HP:0100646)	2.83492431
27	Methylmalonic acidemia (HP:0002912)	2.82784582
28	Aplastic anemia (HP:0001915)	2.80873166
29	Optic disc pallor (HP:0000543)	2.76261691
30	Type II lissencephaly (HP:0007260)	2.63534684
31	Abnormality of the renal cortex (HP:0011035)	2.63164175
32	Hypoproteinemia (HP:0003075)	2.59333530
33	Abolished electroretinogram (ERG) (HP:0000550)	2.58336192
34	Pendular nystagmus (HP:0012043)	2.53723461
35	Attenuation of retinal blood vessels (HP:0007843)	2.51304654
36	Absent thumb (HP:0009777)	2.50489511
37	Stomatitis (HP:0010280)	2.46889962
38	Increased muscle lipid content (HP:0009058)	2.45342140
39	Reticulocytopenia (HP:0001896)	2.45183301
40	Congenital, generalized hypertrichosis (HP:0004540)	2.45043343
41	Decreased central vision (HP:0007663)	2.44218757
42	Nephronophthisis (HP:0000090)	2.38782044
43	Methylmalonic aciduria (HP:0012120)	2.38050099
44	Renal cortical cysts (HP:0000803)	2.36942803
45	Exertional dyspnea (HP:0002875)	2.36704206
46	Hyperglycinemia (HP:0002154)	2.35572371
47	Increased serum lactate (HP:0002151)	2.29479660
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27485921
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26594553
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26594553
51	Abnormality of B cell number (HP:0010975)	2.25222140
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24854513
53	Lactic acidosis (HP:0003128)	2.20579060
54	Polydipsia (HP:0001959)	2.20471613
55	Abnormal drinking behavior (HP:0030082)	2.20471613
56	Abnormal number of erythroid precursors (HP:0012131)	2.19460681
57	Cystic liver disease (HP:0006706)	2.16152794
58	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15753179
59	Panhypogammaglobulinemia (HP:0003139)	2.15413905
60	Lethargy (HP:0001254)	2.13624863
61	Medial flaring of the eyebrow (HP:0010747)	2.12778122
62	Constricted visual fields (HP:0001133)	2.12700439
63	Abnormality of the renal medulla (HP:0100957)	2.09996862
64	Abnormality of the prostate (HP:0008775)	2.07564685
65	Asplenia (HP:0001746)	2.06022361
66	Abnormality of T cell number (HP:0011839)	2.04483207
67	Abnormality of renal resorption (HP:0011038)	2.04299437
68	Colon cancer (HP:0003003)	2.03106263
69	Abnormality of urine glucose concentration (HP:0011016)	2.02751764
70	Glycosuria (HP:0003076)	2.02751764
71	Combined immunodeficiency (HP:0005387)	2.00275533
72	Abnormality of DNA repair (HP:0003254)	2.00225629
73	Sclerocornea (HP:0000647)	1.99269824
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98820125
75	Ketosis (HP:0001946)	1.96220277
76	Pancytopenia (HP:0001876)	1.95156017
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.94736423
78	Dicarboxylic aciduria (HP:0003215)	1.94736423
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.93255400
80	T lymphocytopenia (HP:0005403)	1.92384280
81	Keratoconus (HP:0000563)	1.92332373
82	Increased corneal curvature (HP:0100692)	1.92332373
83	Abnormality of T cells (HP:0002843)	1.91887242
84	Increased IgM level (HP:0003496)	1.91542644
85	B lymphocytopenia (HP:0010976)	1.91268414
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91183976
87	Respiratory failure (HP:0002878)	1.91015630
88	Type 2 muscle fiber atrophy (HP:0003554)	1.88674909
89	Abnormality of the pons (HP:0007361)	1.85325097
90	Exercise intolerance (HP:0003546)	1.83149295
91	Type I transferrin isoform profile (HP:0003642)	1.82672963
92	Macrocytic anemia (HP:0001972)	1.82473998
93	Tubular atrophy (HP:0000092)	1.80712407
94	Chronic mucocutaneous candidiasis (HP:0002728)	1.80324845
95	Recurrent cutaneous fungal infections (HP:0011370)	1.80324845
96	Hypoplasia of the pons (HP:0012110)	1.79005009
97	Generalized aminoaciduria (HP:0002909)	1.77933835
98	Leukodystrophy (HP:0002415)	1.77512536
99	Abnormality of eosinophils (HP:0001879)	1.77305491
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76482925

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.35011911
2	TXK	3.34496302
3	VRK2	3.10325105
4	BCKDK	3.04691767
5	ZAK	2.89585906
6	MAP4K2	2.88551448
7	KDR	2.86606411
8	ADRBK2	2.76032581
9	BMPR1B	2.66788482
10	GRK1	2.50222802
11	NUAK1	2.50049031
12	TAOK3	2.22790629
13	TLK1	2.08041960
14	TESK2	1.80141068
15	MAP3K9	1.64690734
16	WNK4	1.64053204
17	EIF2AK3	1.62796096
18	VRK1	1.57637903
19	MST4	1.50863502
20	STK16	1.48046034
21	TIE1	1.34821805
22	PINK1	1.30722798
23	WNK3	1.29225899
24	TEC	1.27279906
25	PLK2	1.23290383
26	TAF1	1.23053706
27	PIK3CG	1.21854057
28	ITK	1.15435024
29	INSRR	1.14986203
30	EIF2AK1	1.13390664
31	PRKCQ	1.13098831
32	GRK6	1.10142661
33	MAP4K1	1.06802939
34	CDK19	1.06557391
35	KIT	1.02507484
36	TRIM28	0.99610202
37	CAMKK2	0.98057000
38	MAP3K12	0.96924815
39	IKBKB	0.95860687
40	OXSR1	0.92195089
41	DYRK2	0.91564575
42	LIMK1	0.88951452
43	MUSK	0.88941557
44	PASK	0.88913050
45	BUB1	0.87289423
46	CDK8	0.85588952
47	TGFBR1	0.85549004
48	SYK	0.82334937
49	ADRBK1	0.80926941
50	GRK7	0.78862730
51	CSNK1G3	0.78300744
52	ERBB3	0.77939949
53	PLK3	0.76176054
54	CSNK1G1	0.70976920
55	STK39	0.69924374
56	CSNK1G2	0.68536590
57	DAPK2	0.68390442
58	MAPK13	0.66814198
59	LCK	0.66445999
60	PLK4	0.66443559
61	TNIK	0.66035181
62	FES	0.64966296
63	NEK1	0.64159949
64	NME1	0.63846520
65	PIK3CA	0.63149806
66	ACVR1B	0.59537178
67	LRRK2	0.59215822
68	PRKCE	0.56903162
69	DAPK3	0.53321385
70	GRK5	0.52776400
71	CASK	0.51996346
72	RPS6KA5	0.51518458
73	MAPKAPK3	0.51509149
74	DAPK1	0.50831258
75	BTK	0.49321957
76	PLK1	0.49279242
77	OBSCN	0.48520187
78	PRKCG	0.47939607
79	LYN	0.46639066
80	MAP2K6	0.46630845
81	PAK3	0.46295425
82	PRKACA	0.44687238
83	PRKCA	0.44354005
84	AURKA	0.42624001
85	CSNK2A2	0.42463094
86	MAPKAPK5	0.41482409
87	MYLK	0.41443795
88	CSNK1A1L	0.40030432
89	ATR	0.38248703
90	MAP3K4	0.38243551
91	IKBKE	0.37935929
92	SRPK1	0.37778363
93	FLT3	0.37403407
94	PIM2	0.36383684
95	CSNK1A1	0.36202401
96	IGF1R	0.35450783
97	MKNK2	0.34978250
98	CSNK2A1	0.34379171
99	PRKCI	0.33205332
100	MKNK1	0.33046025

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.82561614
2	Ribosome_Homo sapiens_hsa03010	3.59434720
3	Proteasome_Homo sapiens_hsa03050	3.41206046
4	Parkinsons disease_Homo sapiens_hsa05012	3.21012467
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.02385298
6	Protein export_Homo sapiens_hsa03060	2.41342899
7	RNA polymerase_Homo sapiens_hsa03020	2.22172675
8	Allograft rejection_Homo sapiens_hsa05330	2.21303488
9	Asthma_Homo sapiens_hsa05310	2.21295100
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16793372
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11075344
12	Alzheimers disease_Homo sapiens_hsa05010	2.05284252
13	Huntingtons disease_Homo sapiens_hsa05016	2.00348845
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.98217906
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92387178
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.91589556
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89414492
18	Phototransduction_Homo sapiens_hsa04744	1.86019666
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81601516
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.81166882
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78710824
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77510343
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68293370
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66425953
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.52287105
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.51754438
27	Homologous recombination_Homo sapiens_hsa03440	1.50448204
28	RNA degradation_Homo sapiens_hsa03018	1.47397368
29	One carbon pool by folate_Homo sapiens_hsa00670	1.47224698
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39329642
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33928814
32	Propanoate metabolism_Homo sapiens_hsa00640	1.33422935
33	Butanoate metabolism_Homo sapiens_hsa00650	1.32906550
34	Basal transcription factors_Homo sapiens_hsa03022	1.30997671
35	Caffeine metabolism_Homo sapiens_hsa00232	1.24799822
36	Peroxisome_Homo sapiens_hsa04146	1.20651203
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20314609
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.18502840
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17418799
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16505428
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.09486889
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00151339
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99770306
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98762579
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.97340527
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96559568
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94423221
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93203192
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92880425
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85448512
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85050435
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80353054
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.80340928
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79272518
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.78932135
56	Purine metabolism_Homo sapiens_hsa00230	0.78062845
57	Olfactory transduction_Homo sapiens_hsa04740	0.76120196
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.74313594
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74114745
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72336651
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69968932
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68204559
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66745095
64	RNA transport_Homo sapiens_hsa03013	0.66624523
65	Retinol metabolism_Homo sapiens_hsa00830	0.66106774
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65151800
67	Metabolic pathways_Homo sapiens_hsa01100	0.64865964
68	Regulation of autophagy_Homo sapiens_hsa04140	0.62304234
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.60899731
70	Mismatch repair_Homo sapiens_hsa03430	0.59166200
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57919744
72	Spliceosome_Homo sapiens_hsa03040	0.55420711
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54695407
74	Sulfur metabolism_Homo sapiens_hsa00920	0.54620010
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53556934
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52540464
77	Nicotine addiction_Homo sapiens_hsa05033	0.51541957
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51339052
79	Taste transduction_Homo sapiens_hsa04742	0.48419391
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47354233
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46903774
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43546147
83	Base excision repair_Homo sapiens_hsa03410	0.41301359
84	Fatty acid degradation_Homo sapiens_hsa00071	0.38497108
85	Viral myocarditis_Homo sapiens_hsa05416	0.36714659
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36023677
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.34880167
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33344651
89	Mineral absorption_Homo sapiens_hsa04978	0.32725946
90	Sulfur relay system_Homo sapiens_hsa04122	0.31798435
91	Glutathione metabolism_Homo sapiens_hsa00480	0.28049702
92	Measles_Homo sapiens_hsa05162	0.26511277
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.25621641
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25601247
95	Morphine addiction_Homo sapiens_hsa05032	0.21717058
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20809734
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.20652183
98	DNA replication_Homo sapiens_hsa03030	0.20360788
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19704650
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.18327886

RPS11P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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