ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.22612624
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.11688142
3	response to pheromone (GO:0019236)	4.08085228
4	regulation of gene silencing by miRNA (GO:0060964)	3.88049544
5	regulation of gene silencing by RNA (GO:0060966)	3.88049544
6	regulation of posttranscriptional gene silencing (GO:0060147)	3.88049544
7	fucose catabolic process (GO:0019317)	3.86982434
8	L-fucose metabolic process (GO:0042354)	3.86982434
9	L-fucose catabolic process (GO:0042355)	3.86982434
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.59799145
11	platelet dense granule organization (GO:0060155)	3.53985576
12	neuronal action potential (GO:0019228)	3.46626621
13	nephron tubule morphogenesis (GO:0072078)	3.35125660
14	nephron epithelium morphogenesis (GO:0072088)	3.35125660
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.28275490
16	negative regulation of telomere maintenance (GO:0032205)	3.21111290
17	cellular ketone body metabolic process (GO:0046950)	3.17679484
18	pyrimidine nucleobase catabolic process (GO:0006208)	3.15391267
19	regulation of cilium movement (GO:0003352)	3.15340486
20	protein-cofactor linkage (GO:0018065)	3.12848455
21	regulation of action potential (GO:0098900)	3.10428472
22	ubiquinone biosynthetic process (GO:0006744)	3.04962463
23	tryptophan catabolic process (GO:0006569)	3.03692808
24	indole-containing compound catabolic process (GO:0042436)	3.03692808
25	indolalkylamine catabolic process (GO:0046218)	3.03692808
26	indolalkylamine metabolic process (GO:0006586)	3.00875190
27	gamma-aminobutyric acid transport (GO:0015812)	3.00810946
28	glycerophospholipid catabolic process (GO:0046475)	3.00687358
29	DNA deamination (GO:0045006)	3.00373801
30	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.99754368
31	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98260804
32	negative regulation of mast cell activation (GO:0033004)	2.98041559
33	kynurenine metabolic process (GO:0070189)	2.97221373
34	protein complex biogenesis (GO:0070271)	2.94323021
35	transmission of nerve impulse (GO:0019226)	2.93992966
36	reflex (GO:0060004)	2.93830969
37	ATP synthesis coupled proton transport (GO:0015986)	2.92657196
38	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92657196
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.92356615
40	detection of light stimulus involved in visual perception (GO:0050908)	2.92356615
41	peristalsis (GO:0030432)	2.88577455
42	synaptic transmission, cholinergic (GO:0007271)	2.87435637
43	histone H4-K12 acetylation (GO:0043983)	2.86301555
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85288540
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85288540
46	NADH dehydrogenase complex assembly (GO:0010257)	2.85288540
47	multicellular organism reproduction (GO:0032504)	2.84537056
48	ubiquinone metabolic process (GO:0006743)	2.84150130
49	retinal cone cell development (GO:0046549)	2.83757403
50	nucleobase catabolic process (GO:0046113)	2.82925779
51	epithelial cilium movement (GO:0003351)	2.82852644
52	protein polyglutamylation (GO:0018095)	2.78997681
53	rhodopsin mediated signaling pathway (GO:0016056)	2.78789953
54	ketone body metabolic process (GO:1902224)	2.77702445
55	auditory behavior (GO:0031223)	2.77497490
56	regulation of neurotransmitter uptake (GO:0051580)	2.76606914
57	cornea development in camera-type eye (GO:0061303)	2.76132812
58	phasic smooth muscle contraction (GO:0014821)	2.74569344
59	renal tubule morphogenesis (GO:0061333)	2.74345538
60	nonmotile primary cilium assembly (GO:0035058)	2.73879257
61	behavioral response to ethanol (GO:0048149)	2.73786731
62	auditory receptor cell stereocilium organization (GO:0060088)	2.72141784
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.71384202
64	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.69877354
65	protein localization to cilium (GO:0061512)	2.67120032
66	piRNA metabolic process (GO:0034587)	2.65785824
67	membrane depolarization during action potential (GO:0086010)	2.65663984
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62776895
69	positive regulation of fatty acid transport (GO:2000193)	2.61957895
70	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.61359681
71	regulation of microtubule-based movement (GO:0060632)	2.61133087
72	inner ear receptor stereocilium organization (GO:0060122)	2.61025192
73	tryptophan metabolic process (GO:0006568)	2.60345808
74	photoreceptor cell development (GO:0042461)	2.59604139
75	cilium morphogenesis (GO:0060271)	2.59076206
76	hindbrain development (GO:0030902)	2.57539938
77	indole-containing compound metabolic process (GO:0042430)	2.57038345
78	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.56562832
79	axoneme assembly (GO:0035082)	2.55445169
80	respiratory chain complex IV assembly (GO:0008535)	2.54327912
81	primary amino compound metabolic process (GO:1901160)	2.51007165
82	somite development (GO:0061053)	2.49487123
83	positive regulation of protein homodimerization activity (GO:0090073)	2.48871193
84	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.47482691
85	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.45587476
86	amine catabolic process (GO:0009310)	2.44731214
87	cellular biogenic amine catabolic process (GO:0042402)	2.44731214
88	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.44459446
89	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.44459446
90	dendritic spine morphogenesis (GO:0060997)	2.43813408
91	action potential (GO:0001508)	2.43510979
92	positive regulation of action potential (GO:0045760)	2.43463506
93	neural tube formation (GO:0001841)	2.43062828
94	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.41655560
95	cilium organization (GO:0044782)	2.41259411
96	parturition (GO:0007567)	2.41125429
97	mannosylation (GO:0097502)	2.41104912
98	serotonin metabolic process (GO:0042428)	2.40898628
99	cellular response to ATP (GO:0071318)	2.40686579
100	sperm motility (GO:0030317)	2.40614676

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.35376193
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68141142
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18695204
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81010003
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79665098
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.50119921
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40576578
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.33278986
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17703254
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15810586
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05982528
12	FUS_26573619_Chip-Seq_HEK293_Human	1.95574330
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95008026
14	P300_19829295_ChIP-Seq_ESCs_Human	1.90475747
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.90387655
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86341619
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.85854354
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81449717
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79025556
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78074967
21	EWS_26573619_Chip-Seq_HEK293_Human	1.77147094
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.76580401
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.66046984
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.64978096
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63543962
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.60411750
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58064677
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57150707
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.56144924
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52972140
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.49079809
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44247358
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43841731
34	AR_25329375_ChIP-Seq_VCAP_Human	1.42562182
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41390160
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.41390160
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.39580192
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39321749
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38997911
40	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.37863403
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37247594
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37184869
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.37125560
44	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37081546
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36862813
46	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.36816663
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36716544
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32761839
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32528446
50	TCF4_23295773_ChIP-Seq_U87_Human	1.32475343
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31526137
52	STAT3_23295773_ChIP-Seq_U87_Human	1.30833147
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30332783
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30332783
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28662043
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28458804
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.28391147
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.28072229
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.27720048
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26333079
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26333079
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26193437
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26193437
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25625768
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24955101
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23995559
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.23053238
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.22726102
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21061390
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19996186
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19972270
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19893275
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19248510
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18073793
75	AR_20517297_ChIP-Seq_VCAP_Human	1.14343924
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13801763
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12712762
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11701815
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10969593
80	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10752239
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10322101
82	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09130976
83	NCOR_22424771_ChIP-Seq_293T_Human	1.08680962
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07609512
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06904910
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06732881
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05178060
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05120492
89	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.04292118
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03494697
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03265604
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01592507
93	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01292437
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01047109
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00659757
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00650770
97	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99962159
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98961038
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97609024
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97001302

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.97490743
2	MP0003880_abnormal_central_pattern	2.70950874
3	MP0001986_abnormal_taste_sensitivity	2.64304818
4	MP0002638_abnormal_pupillary_reflex	2.56446299
5	MP0004885_abnormal_endolymph	2.54364408
6	MP0005551_abnormal_eye_electrophysiolog	2.51799549
7	MP0002837_dystrophic_cardiac_calcinosis	2.37581572
8	MP0001968_abnormal_touch/_nociception	2.34299970
9	MP0003136_yellow_coat_color	2.33903417
10	MP0002102_abnormal_ear_morphology	2.33147293
11	MP0003787_abnormal_imprinting	2.30925404
12	MP0006072_abnormal_retinal_apoptosis	2.24575106
13	MP0004142_abnormal_muscle_tone	2.02189351
14	MP0002653_abnormal_ependyma_morphology	2.01324338
15	MP0003011_delayed_dark_adaptation	2.00969473
16	MP0004147_increased_porphyrin_level	1.98286414
17	MP0009745_abnormal_behavioral_response	1.96191674
18	MP0002272_abnormal_nervous_system	1.95124502
19	MP0001486_abnormal_startle_reflex	1.90832377
20	MP0003195_calcinosis	1.90636228
21	MP0009046_muscle_twitch	1.87355928
22	MP0008875_abnormal_xenobiotic_pharmacok	1.86869198
23	MP0002876_abnormal_thyroid_physiology	1.78951462
24	MP0008872_abnormal_physiological_respon	1.78020376
25	MP0002736_abnormal_nociception_after	1.75156836
26	MP0002735_abnormal_chemical_nociception	1.72744780
27	MP0006292_abnormal_olfactory_placode	1.72173728
28	MP0001188_hyperpigmentation	1.72085772
29	MP0005253_abnormal_eye_physiology	1.71555807
30	MP0005646_abnormal_pituitary_gland	1.66506856
31	MP0001984_abnormal_olfaction	1.65787090
32	MP0002733_abnormal_thermal_nociception	1.61317986
33	MP0005084_abnormal_gallbladder_morpholo	1.56983386
34	MP0001905_abnormal_dopamine_level	1.56014811
35	MP0005645_abnormal_hypothalamus_physiol	1.54922149
36	MP0002572_abnormal_emotion/affect_behav	1.50812462
37	MP0005423_abnormal_somatic_nervous	1.49800760
38	MP0002064_seizures	1.47576575
39	MP0001485_abnormal_pinna_reflex	1.45932506
40	MP0004742_abnormal_vestibular_system	1.42981979
41	MP0000427_abnormal_hair_cycle	1.41781934
42	MP0001970_abnormal_pain_threshold	1.41009349
43	MP0001501_abnormal_sleep_pattern	1.39530367
44	MP0003646_muscle_fatigue	1.39098454
45	MP0003635_abnormal_synaptic_transmissio	1.37327408
46	MP0004043_abnormal_pH_regulation	1.37242591
47	MP0005671_abnormal_response_to	1.35915337
48	MP0003878_abnormal_ear_physiology	1.35231023
49	MP0005377_hearing/vestibular/ear_phenot	1.35231023
50	MP0002938_white_spotting	1.33841948
51	MP0006276_abnormal_autonomic_nervous	1.30959355
52	MP0002067_abnormal_sensory_capabilities	1.30679066
53	MP0002063_abnormal_learning/memory/cond	1.29911018
54	MP0004133_heterotaxia	1.28189975
55	MP0002734_abnormal_mechanical_nocicepti	1.27920549
56	MP0005195_abnormal_posterior_eye	1.24030857
57	MP0002557_abnormal_social/conspecific_i	1.23357434
58	MP0005386_behavior/neurological_phenoty	1.22215287
59	MP0004924_abnormal_behavior	1.22215287
60	MP0002277_abnormal_respiratory_mucosa	1.22042018
61	MP0000778_abnormal_nervous_system	1.21699184
62	MP0002909_abnormal_adrenal_gland	1.15972443
63	MP0000631_abnormal_neuroendocrine_gland	1.12673978
64	MP0000026_abnormal_inner_ear	1.12259079
65	MP0002184_abnormal_innervation	1.10393486
66	MP0005174_abnormal_tail_pigmentation	1.09896858
67	MP0000569_abnormal_digit_pigmentation	1.09571114
68	MP0001529_abnormal_vocalization	1.08246997
69	MP0002160_abnormal_reproductive_system	1.06478061
70	MP0002752_abnormal_somatic_nervous	1.05407863
71	MP0004145_abnormal_muscle_electrophysio	1.05365793
72	MP0002229_neurodegeneration	1.04181124
73	MP0005389_reproductive_system_phenotype	1.02913816
74	MP0001293_anophthalmia	1.00491172
75	MP0002234_abnormal_pharynx_morphology	0.99951459
76	MP0002928_abnormal_bile_duct	0.99011900
77	MP0005379_endocrine/exocrine_gland_phen	0.98960689
78	MP0010386_abnormal_urinary_bladder	0.98486945
79	MP0001963_abnormal_hearing_physiology	0.98362294
80	MP0000372_irregular_coat_pigmentation	0.96206048
81	MP0003121_genomic_imprinting	0.95581857
82	MP0001440_abnormal_grooming_behavior	0.94963425
83	MP0000955_abnormal_spinal_cord	0.92467735
84	MP0001502_abnormal_circadian_rhythm	0.92270128
85	MP0002163_abnormal_gland_morphology	0.92099284
86	MP0005075_abnormal_melanosome_morpholog	0.91968668
87	MP0001919_abnormal_reproductive_system	0.87990356
88	MP0000230_abnormal_systemic_arterial	0.87905022
89	MP0001324_abnormal_eye_pigmentation	0.87505030
90	MP0008775_abnormal_heart_ventricle	0.87436365
91	MP0004215_abnormal_myocardial_fiber	0.87147149
92	MP0002882_abnormal_neuron_morphology	0.86219065
93	MP0002138_abnormal_hepatobiliary_system	0.85645277
94	MP0002095_abnormal_skin_pigmentation	0.80013992
95	MP0003122_maternal_imprinting	0.79591006
96	MP0004019_abnormal_vitamin_homeostasis	0.76684281
97	MP0005410_abnormal_fertilization	0.76486255
98	MP0003638_abnormal_response/metabolism_	0.76075084
99	MP0009780_abnormal_chondrocyte_physiolo	0.72766668
100	MP0000049_abnormal_middle_ear	0.70806728

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.79826389
2	Pancreatic cysts (HP:0001737)	4.11697378
3	Molar tooth sign on MRI (HP:0002419)	4.00845554
4	Abnormality of midbrain morphology (HP:0002418)	4.00845554
5	True hermaphroditism (HP:0010459)	3.96503159
6	Pancreatic fibrosis (HP:0100732)	3.95796359
7	Nephronophthisis (HP:0000090)	3.62794433
8	Medial flaring of the eyebrow (HP:0010747)	3.51717810
9	Abnormality of the renal cortex (HP:0011035)	3.19368475
10	Stomach cancer (HP:0012126)	3.15133895
11	Hyperventilation (HP:0002883)	3.14604081
12	Gait imbalance (HP:0002141)	3.07212358
13	Abnormality of the renal medulla (HP:0100957)	3.03801661
14	Large for gestational age (HP:0001520)	3.02551570
15	Congenital primary aphakia (HP:0007707)	2.87404469
16	Type II lissencephaly (HP:0007260)	2.79524543
17	Renal cortical cysts (HP:0000803)	2.71746467
18	3-Methylglutaconic aciduria (HP:0003535)	2.71183725
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.64746148
20	Nephrogenic diabetes insipidus (HP:0009806)	2.64074174
21	Congenital, generalized hypertrichosis (HP:0004540)	2.55681753
22	Progressive cerebellar ataxia (HP:0002073)	2.55349533
23	Abolished electroretinogram (ERG) (HP:0000550)	2.55001116
24	Sclerocornea (HP:0000647)	2.54426151
25	Vaginal atresia (HP:0000148)	2.53862601
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.53396246
27	Cystic liver disease (HP:0006706)	2.53054559
28	Genital tract atresia (HP:0001827)	2.52915241
29	Chronic hepatic failure (HP:0100626)	2.42351794
30	Broad-based gait (HP:0002136)	2.41379259
31	Methylmalonic acidemia (HP:0002912)	2.37543177
32	Pachygyria (HP:0001302)	2.37173412
33	Asplenia (HP:0001746)	2.36417038
34	Anencephaly (HP:0002323)	2.34043867
35	Attenuation of retinal blood vessels (HP:0007843)	2.32140407
36	Hemiparesis (HP:0001269)	2.29046552
37	Inability to walk (HP:0002540)	2.28650813
38	Tubular atrophy (HP:0000092)	2.26545420
39	Abnormal drinking behavior (HP:0030082)	2.25419284
40	Polydipsia (HP:0001959)	2.25419284
41	Focal motor seizures (HP:0011153)	2.23145588
42	Furrowed tongue (HP:0000221)	2.18768005
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.17055351
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17055351
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15460715
46	Absent/shortened dynein arms (HP:0200106)	2.15460715
47	Methylmalonic aciduria (HP:0012120)	2.12405429
48	Lissencephaly (HP:0001339)	2.12201098
49	Abnormality of the labia minora (HP:0012880)	2.11900270
50	Pendular nystagmus (HP:0012043)	2.09015783
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07444757
52	Abnormality of alanine metabolism (HP:0010916)	2.07167777
53	Hyperalaninemia (HP:0003348)	2.07167777
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07167777
55	Mitochondrial inheritance (HP:0001427)	2.05335307
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05317647
57	Keratoconus (HP:0000563)	2.05309470
58	Increased corneal curvature (HP:0100692)	2.05309470
59	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02756271
60	Acute necrotizing encephalopathy (HP:0006965)	2.01912721
61	Male pseudohermaphroditism (HP:0000037)	1.99697648
62	Tachypnea (HP:0002789)	1.98194099
63	Increased CSF lactate (HP:0002490)	1.97676012
64	Severe muscular hypotonia (HP:0006829)	1.96907744
65	Concave nail (HP:0001598)	1.96889544
66	Poor coordination (HP:0002370)	1.96708026
67	Polyphagia (HP:0002591)	1.95248554
68	Progressive inability to walk (HP:0002505)	1.94402334
69	Oligodactyly (hands) (HP:0001180)	1.92959593
70	Polyuria (HP:0000103)	1.92067024
71	Postaxial foot polydactyly (HP:0001830)	1.91258064
72	Congenital hepatic fibrosis (HP:0002612)	1.91096721
73	Optic disc pallor (HP:0000543)	1.89915373
74	Gaze-evoked nystagmus (HP:0000640)	1.89388452
75	Febrile seizures (HP:0002373)	1.87788116
76	Abnormal ciliary motility (HP:0012262)	1.87283382
77	Progressive macrocephaly (HP:0004481)	1.87005481
78	Acute encephalopathy (HP:0006846)	1.86354376
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85795224
80	Postaxial hand polydactyly (HP:0001162)	1.85294055
81	Decreased circulating renin level (HP:0003351)	1.84229757
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83962137
83	Limb dystonia (HP:0002451)	1.83469655
84	Hyperglycinemia (HP:0002154)	1.82838323
85	Abnormality of the pons (HP:0007361)	1.78533392
86	Optic nerve hypoplasia (HP:0000609)	1.78309442
87	Hypothermia (HP:0002045)	1.78232963
88	Decreased central vision (HP:0007663)	1.78063420
89	Focal seizures (HP:0007359)	1.76059351
90	Agitation (HP:0000713)	1.76050459
91	Specific learning disability (HP:0001328)	1.75279780
92	Abnormal biliary tract physiology (HP:0012439)	1.75156478
93	Bile duct proliferation (HP:0001408)	1.75156478
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.73880571
95	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71063545
96	Supernumerary spleens (HP:0009799)	1.70864638
97	Increased serum lactate (HP:0002151)	1.70544906
98	Hepatocellular necrosis (HP:0001404)	1.70345519
99	Abnormal number of erythroid precursors (HP:0012131)	1.69298426
100	Nephrotic syndrome (HP:0000100)	1.69158137

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.74728995
2	ADRBK2	3.58474728
3	GRK1	3.27657589
4	TAOK3	3.26381307
5	CASK	3.13317821
6	WNK4	3.06045255
7	ZAK	2.87485369
8	PINK1	2.85382321
9	TLK1	2.83568496
10	BMPR1B	2.30274191
11	MAP4K2	2.15282138
12	WNK3	2.12212568
13	STK16	1.95218758
14	MAP3K4	1.79451817
15	MAPK13	1.77627773
16	PNCK	1.62978741
17	NUAK1	1.59204097
18	TXK	1.56926325
19	AKT3	1.56855052
20	INSRR	1.43594173
21	MUSK	1.42837128
22	MARK1	1.42027889
23	STK39	1.41673692
24	DYRK2	1.41463509
25	TNIK	1.32566493
26	ACVR1B	1.29047599
27	PAK3	1.27989540
28	OXSR1	1.26424429
29	IRAK4	1.26169094
30	EPHA3	1.23472633
31	VRK1	1.13217952
32	NTRK3	1.12072038
33	NTRK2	1.11897688
34	PHKG1	1.06993457
35	PHKG2	1.06993457
36	CAMKK2	1.05450405
37	TAF1	0.98256174
38	BCKDK	0.97734941
39	TIE1	0.95088224
40	MAP2K7	0.95038464
41	TESK2	0.94603728
42	PRKCG	0.94267204
43	ADRBK1	0.93161924
44	KIT	0.92512341
45	DAPK2	0.90767944
46	MAPK15	0.86795662
47	PRKCE	0.84443568
48	FGFR2	0.74768191
49	MARK3	0.72817182
50	PTK2B	0.71950884
51	ERBB3	0.69048237
52	TGFBR1	0.67825708
53	TRIM28	0.67156563
54	SIK2	0.65934026
55	PLK2	0.65752155
56	VRK2	0.64960092
57	MAPKAPK3	0.63963806
58	IKBKB	0.63623867
59	PKN1	0.62171058
60	NME1	0.61347366
61	WNK1	0.60455990
62	CDK19	0.60270685
63	RPS6KA5	0.59993989
64	MAP2K2	0.59773007
65	PRKCQ	0.58733826
66	PRKCI	0.57098155
67	PIK3CA	0.54615263
68	CAMK2A	0.53190645
69	PRKACA	0.53092753
70	CSNK1G2	0.50503921
71	PRKCZ	0.48830136
72	NLK	0.48596976
73	SYK	0.48033807
74	CSNK1G1	0.46734750
75	ITK	0.45158027
76	MAP2K6	0.42294264
77	STK11	0.42018852
78	TEC	0.41915905
79	CAMKK1	0.41394698
80	CAMK2D	0.40991667
81	IRAK1	0.40452102
82	STK38L	0.38411624
83	OBSCN	0.37745413
84	MKNK2	0.37393968
85	ILK	0.37076982
86	CSNK1G3	0.35603069
87	MAP2K4	0.35356232
88	BRSK2	0.35298936
89	PIK3CG	0.35018886
90	SGK2	0.34916699
91	SGK494	0.34511045
92	SGK223	0.34511045
93	PASK	0.34452690
94	MAPKAPK5	0.34337971
95	TNK2	0.34316771
96	PRKG1	0.33165922
97	HIPK2	0.33017144
98	PLK3	0.32040671
99	GRK6	0.31797731
100	PIM1	0.30712624

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.07405139
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61027277
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.58943320
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.46728033
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.42387189
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42126983
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27351947
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24832164
9	Nicotine addiction_Homo sapiens_hsa05033	2.21162292
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15626342
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.12708917
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.01433862
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99427728
14	Parkinsons disease_Homo sapiens_hsa05012	1.99371462
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97621663
16	Butanoate metabolism_Homo sapiens_hsa00650	1.92455238
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.67738638
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66395759
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.61227241
20	Caffeine metabolism_Homo sapiens_hsa00232	1.59684178
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.55486722
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54977898
23	Taste transduction_Homo sapiens_hsa04742	1.54004195
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46988333
25	Protein export_Homo sapiens_hsa03060	1.46636493
26	Morphine addiction_Homo sapiens_hsa05032	1.45869470
27	Basal transcription factors_Homo sapiens_hsa03022	1.40205383
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.39620996
29	Regulation of autophagy_Homo sapiens_hsa04140	1.39527494
30	Alzheimers disease_Homo sapiens_hsa05010	1.33627922
31	Olfactory transduction_Homo sapiens_hsa04740	1.27853524
32	RNA polymerase_Homo sapiens_hsa03020	1.26837086
33	Insulin secretion_Homo sapiens_hsa04911	1.23992467
34	Ribosome_Homo sapiens_hsa03010	1.23559927
35	Propanoate metabolism_Homo sapiens_hsa00640	1.22240472
36	Huntingtons disease_Homo sapiens_hsa05016	1.18785905
37	GABAergic synapse_Homo sapiens_hsa04727	1.17677055
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.16769428
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16245128
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15900379
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.15351059
42	Circadian entrainment_Homo sapiens_hsa04713	1.15143980
43	Serotonergic synapse_Homo sapiens_hsa04726	1.13220095
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.11700250
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07798666
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06641837
47	Peroxisome_Homo sapiens_hsa04146	1.05426310
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.02217766
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95979207
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94356592
51	Homologous recombination_Homo sapiens_hsa03440	0.93221807
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91570509
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89698090
54	RNA degradation_Homo sapiens_hsa03018	0.87763144
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87048540
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84922520
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.84749611
58	Retinol metabolism_Homo sapiens_hsa00830	0.83545618
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82585456
60	One carbon pool by folate_Homo sapiens_hsa00670	0.80604146
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79379742
62	ABC transporters_Homo sapiens_hsa02010	0.78531320
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78316832
64	Salivary secretion_Homo sapiens_hsa04970	0.77221606
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.72884569
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72333605
67	Asthma_Homo sapiens_hsa05310	0.71413840
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68646549
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68402579
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.68304467
71	Cocaine addiction_Homo sapiens_hsa05030	0.64606999
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63394213
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.62570215
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60460747
75	Amphetamine addiction_Homo sapiens_hsa05031	0.59736278
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59591376
77	Fatty acid elongation_Homo sapiens_hsa00062	0.59557868
78	Purine metabolism_Homo sapiens_hsa00230	0.57017046
79	Sulfur relay system_Homo sapiens_hsa04122	0.57007908
80	Metabolic pathways_Homo sapiens_hsa01100	0.55288758
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52373541
82	Proteasome_Homo sapiens_hsa03050	0.52225685
83	Sulfur metabolism_Homo sapiens_hsa00920	0.51372436
84	Long-term depression_Homo sapiens_hsa04730	0.51323108
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50636836
86	Histidine metabolism_Homo sapiens_hsa00340	0.49905593
87	Renin secretion_Homo sapiens_hsa04924	0.46867302
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.45707474
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45296917
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45056511
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44088102
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42536758
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.42196060
94	Mineral absorption_Homo sapiens_hsa04978	0.41601406
95	Cholinergic synapse_Homo sapiens_hsa04725	0.41011059
96	Gastric acid secretion_Homo sapiens_hsa04971	0.40910062
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38892753
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37548578
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31515637
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.29495642

RPS11P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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