RPS11P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.86041237
2ATP synthesis coupled proton transport (GO:0015986)6.41335320
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.41335320
4ribosomal small subunit assembly (GO:0000028)6.02403463
5viral transcription (GO:0019083)5.41144125
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.34965034
7translational termination (GO:0006415)5.22636624
8respiratory electron transport chain (GO:0022904)5.05226633
9electron transport chain (GO:0022900)4.99580455
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.88467589
11cotranslational protein targeting to membrane (GO:0006613)4.81653359
12DNA deamination (GO:0045006)4.75086392
13protein targeting to ER (GO:0045047)4.74521956
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.56239606
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54485171
16protein localization to endoplasmic reticulum (GO:0070972)4.50872117
17translational elongation (GO:0006414)4.48143295
18sequestering of actin monomers (GO:0042989)4.18929302
19protein complex biogenesis (GO:0070271)3.93921368
20cellular protein complex disassembly (GO:0043624)3.92295736
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91177886
22viral life cycle (GO:0019058)3.84297235
23hydrogen ion transmembrane transport (GO:1902600)3.77957621
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70996227
25platelet dense granule organization (GO:0060155)3.69036533
26cytidine deamination (GO:0009972)3.63843156
27cytidine metabolic process (GO:0046087)3.63843156
28cytidine catabolic process (GO:0006216)3.63843156
29translational initiation (GO:0006413)3.59459455
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.59021058
31NADH dehydrogenase complex assembly (GO:0010257)3.59021058
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59021058
33ATP biosynthetic process (GO:0006754)3.58360189
34maturation of SSU-rRNA (GO:0030490)3.53851559
35proton transport (GO:0015992)3.50530437
36mitochondrial respiratory chain complex assembly (GO:0033108)3.48849798
37chaperone-mediated protein transport (GO:0072321)3.45417229
38hydrogen transport (GO:0006818)3.43159078
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42502862
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.41001378
41protein neddylation (GO:0045116)3.40789867
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40062059
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40062059
44mannosylation (GO:0097502)3.39460338
45proteasome assembly (GO:0043248)3.39358476
46ribosomal large subunit biogenesis (GO:0042273)3.36106170
47translation (GO:0006412)3.35063710
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32718389
49protein complex disassembly (GO:0043241)3.22597528
50GPI anchor biosynthetic process (GO:0006506)3.20046478
51respiratory chain complex IV assembly (GO:0008535)3.19647120
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17545076
53GPI anchor metabolic process (GO:0006505)3.15479534
54pyrimidine ribonucleoside catabolic process (GO:0046133)3.14174325
55water-soluble vitamin biosynthetic process (GO:0042364)3.09302502
56protein targeting to membrane (GO:0006612)3.08924772
57macromolecular complex disassembly (GO:0032984)3.07559620
58cytochrome complex assembly (GO:0017004)3.04731331
59behavioral response to nicotine (GO:0035095)3.04409223
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.01193062
61termination of RNA polymerase III transcription (GO:0006386)3.01193062
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98092122
63GTP biosynthetic process (GO:0006183)2.92287991
64protein-cofactor linkage (GO:0018065)2.91930066
65regulation of cellular amino acid metabolic process (GO:0006521)2.91691963
66preassembly of GPI anchor in ER membrane (GO:0016254)2.90738133
67nuclear-transcribed mRNA catabolic process (GO:0000956)2.88684843
68negative regulation of heart rate (GO:0010459)2.87299880
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86787586
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86097798
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83435286
72indole-containing compound catabolic process (GO:0042436)2.78623466
73indolalkylamine catabolic process (GO:0046218)2.78623466
74tryptophan catabolic process (GO:0006569)2.78623466
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77640840
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77640840
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77640840
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74998536
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74998536
80cellular ketone body metabolic process (GO:0046950)2.73678275
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73601902
82kynurenine metabolic process (GO:0070189)2.71548541
83adult feeding behavior (GO:0008343)2.70093986
84mRNA catabolic process (GO:0006402)2.67631370
85indolalkylamine metabolic process (GO:0006586)2.64633717
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62096610
87negative regulation of ligase activity (GO:0051352)2.62096610
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.59281542
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59281542
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.59139601
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.55984390
92ribosomal small subunit biogenesis (GO:0042274)2.52713994
93aldehyde catabolic process (GO:0046185)2.52606993
94spliceosomal complex assembly (GO:0000245)2.50375210
95actin nucleation (GO:0045010)2.49964432
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49757675
97dopamine transport (GO:0015872)2.49643653
98nucleoside triphosphate biosynthetic process (GO:0009142)2.48999559
99ketone body metabolic process (GO:1902224)2.46170265
100intracellular protein transmembrane import (GO:0044743)2.45686349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83197160
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.67647167
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.65779637
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.41410931
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28597932
6VDR_22108803_ChIP-Seq_LS180_Human3.01815622
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95877034
8ZNF274_21170338_ChIP-Seq_K562_Hela2.84068866
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82608522
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81209105
11VDR_23849224_ChIP-Seq_CD4+_Human2.38553033
12IGF1R_20145208_ChIP-Seq_DFB_Human2.19579706
13ELK1_19687146_ChIP-ChIP_HELA_Human2.18904493
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.18457195
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10743307
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08498610
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08361129
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.06496709
19EZH2_22144423_ChIP-Seq_EOC_Human2.04906977
20TAF15_26573619_Chip-Seq_HEK293_Human1.98227793
21EWS_26573619_Chip-Seq_HEK293_Human1.97928334
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86526575
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80042583
24MYC_18940864_ChIP-ChIP_HL60_Human1.75730297
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70258939
26FOXP3_21729870_ChIP-Seq_TREG_Human1.69807414
27FUS_26573619_Chip-Seq_HEK293_Human1.68807872
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68648985
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65625660
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64805486
31TP53_22573176_ChIP-Seq_HFKS_Human1.61502536
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61493182
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60871471
34P300_19829295_ChIP-Seq_ESCs_Human1.49748406
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48387617
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.46008078
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44818024
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44385905
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.44385905
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44039845
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42818839
42AR_20517297_ChIP-Seq_VCAP_Human1.42563514
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41586202
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.39156862
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38799293
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36508318
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34621159
48ER_23166858_ChIP-Seq_MCF-7_Human1.33724119
49SOX2_19829295_ChIP-Seq_ESCs_Human1.28353549
50NANOG_19829295_ChIP-Seq_ESCs_Human1.28353549
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.27223162
52CBP_20019798_ChIP-Seq_JUKART_Human1.27164690
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27164690
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26425107
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.21478267
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19526990
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17468275
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16690280
59NCOR_22424771_ChIP-Seq_293T_Human1.16159711
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15371775
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.15097969
62ERG_20517297_ChIP-Seq_VCAP_Human1.14193444
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12868272
64IRF1_19129219_ChIP-ChIP_H3396_Human1.12363757
65GATA3_26560356_Chip-Seq_TH2_Human1.12332120
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.11764263
67TTF2_22483619_ChIP-Seq_HELA_Human1.10763973
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10053020
69RNF2_27304074_Chip-Seq_NSC_Mouse1.09724676
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09553901
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.09292671
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08937355
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08886109
74HTT_18923047_ChIP-ChIP_STHdh_Human1.07645959
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07510052
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07318852
77MYC_19829295_ChIP-Seq_ESCs_Human1.07114159
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.06812757
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03510743
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03381413
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.03178591
82BCAT_22108803_ChIP-Seq_LS180_Human1.02472660
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99621334
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.99485540
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99371286
86TCF4_22108803_ChIP-Seq_LS180_Human0.97410402
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.96861525
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96711182
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.96428182
90TAF2_19829295_ChIP-Seq_ESCs_Human0.95577161
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95423707
92NANOG_20526341_ChIP-Seq_ESCs_Human0.94715703
93GBX2_23144817_ChIP-Seq_PC3_Human0.93258945
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90307645
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88854646
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87390913
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.86871271
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86422291
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86400917
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85393914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.69525320
2MP0005671_abnormal_response_to3.26071369
3MP0006072_abnormal_retinal_apoptosis3.25068725
4MP0006292_abnormal_olfactory_placode2.94241439
5MP0003283_abnormal_digestive_organ2.64606238
6MP0002102_abnormal_ear_morphology2.38147597
7MP0008995_early_reproductive_senescence2.24867683
8MP0002234_abnormal_pharynx_morphology2.20459395
9MP0001835_abnormal_antigen_presentation2.18326239
10MP0003880_abnormal_central_pattern2.12672614
11MP0002837_dystrophic_cardiac_calcinosis1.95930292
12MP0005253_abnormal_eye_physiology1.92262492
13MP0002638_abnormal_pupillary_reflex1.91424946
14MP0004147_increased_porphyrin_level1.89644303
15MP0002938_white_spotting1.84063021
16MP0005645_abnormal_hypothalamus_physiol1.79710683
17MP0008875_abnormal_xenobiotic_pharmacok1.78514901
18MP0005551_abnormal_eye_electrophysiolog1.76371770
19MP0003195_calcinosis1.75236494
20MP0005084_abnormal_gallbladder_morpholo1.70725128
21MP0001905_abnormal_dopamine_level1.70202789
22MP0008872_abnormal_physiological_respon1.63886860
23MP0001529_abnormal_vocalization1.63456646
24MP0000566_synostosis1.63359593
25MP0005646_abnormal_pituitary_gland1.60622641
26MP0004142_abnormal_muscle_tone1.59643378
27MP0008877_abnormal_DNA_methylation1.58796650
28MP0003787_abnormal_imprinting1.51772295
29MP0006276_abnormal_autonomic_nervous1.48101066
30MP0005075_abnormal_melanosome_morpholog1.46791894
31MP0002277_abnormal_respiratory_mucosa1.45789073
32MP0004885_abnormal_endolymph1.44199305
33MP0002166_altered_tumor_susceptibility1.38068290
34MP0003011_delayed_dark_adaptation1.36417568
35MP0009785_altered_susceptibility_to1.34792499
36MP0000372_irregular_coat_pigmentation1.33638494
37MP0002653_abnormal_ependyma_morphology1.33502839
38MP0001919_abnormal_reproductive_system1.27335974
39MP0000631_abnormal_neuroendocrine_gland1.27313919
40MP0003136_yellow_coat_color1.27273394
41MP0005389_reproductive_system_phenotype1.24044642
42MP0001968_abnormal_touch/_nociception1.20364197
43MP0002736_abnormal_nociception_after1.19589049
44MP0002006_tumorigenesis1.18863738
45MP0001986_abnormal_taste_sensitivity1.14191583
46MP0002876_abnormal_thyroid_physiology1.13936335
47MP0005085_abnormal_gallbladder_physiolo1.13756891
48MP0002138_abnormal_hepatobiliary_system1.13701943
49MP0004133_heterotaxia1.13155371
50MP0002095_abnormal_skin_pigmentation1.11006308
51MP0008789_abnormal_olfactory_epithelium1.09802909
52MP0003646_muscle_fatigue1.09347663
53MP0003252_abnormal_bile_duct1.09058086
54MP0009745_abnormal_behavioral_response1.08633674
55MP0003878_abnormal_ear_physiology1.05561301
56MP0005377_hearing/vestibular/ear_phenot1.05561301
57MP0002272_abnormal_nervous_system1.04784357
58MP0003786_premature_aging1.04425153
59MP0001984_abnormal_olfaction1.03499510
60MP0004742_abnormal_vestibular_system1.01518898
61MP0001800_abnormal_humoral_immune1.01406369
62MP0003938_abnormal_ear_development0.99018995
63MP0001764_abnormal_homeostasis0.98561623
64MP0004145_abnormal_muscle_electrophysio0.98519634
65MP0006036_abnormal_mitochondrial_physio0.97072405
66MP0001873_stomach_inflammation0.97037223
67MP0002282_abnormal_trachea_morphology0.94872329
68MP0009046_muscle_twitch0.94149116
69MP0001293_anophthalmia0.94131517
70MP0002148_abnormal_hypersensitivity_rea0.94014895
71MP0005000_abnormal_immune_tolerance0.92614807
72MP0002160_abnormal_reproductive_system0.92199926
73MP0000516_abnormal_urinary_system0.91710846
74MP0005367_renal/urinary_system_phenotyp0.91710846
75MP0002751_abnormal_autonomic_nervous0.91559384
76MP0003122_maternal_imprinting0.90530082
77MP0003724_increased_susceptibility_to0.89310911
78MP0001485_abnormal_pinna_reflex0.88402182
79MP0000569_abnormal_digit_pigmentation0.88195784
80MP0005195_abnormal_posterior_eye0.87027647
81MP0000383_abnormal_hair_follicle0.86183726
82MP0010386_abnormal_urinary_bladder0.85252760
83MP0002693_abnormal_pancreas_physiology0.85112347
84MP0009333_abnormal_splenocyte_physiolog0.85103637
85MP0009764_decreased_sensitivity_to0.83217465
86MP0005636_abnormal_mineral_homeostasis0.82324153
87MP0008058_abnormal_DNA_repair0.81911027
88MP0002723_abnormal_immune_serum0.79499799
89MP0003119_abnormal_digestive_system0.79278382
90MP0005410_abnormal_fertilization0.79072506
91MP0003718_maternal_effect0.79018701
92MP0002557_abnormal_social/conspecific_i0.78647177
93MP0000026_abnormal_inner_ear0.78646131
94MP0003806_abnormal_nucleotide_metabolis0.75158083
95MP0000049_abnormal_middle_ear0.74676076
96MP0001970_abnormal_pain_threshold0.74477169
97MP0005391_vision/eye_phenotype0.71734495
98MP0003121_genomic_imprinting0.70804416
99MP0001486_abnormal_startle_reflex0.70654405
100MP0002928_abnormal_bile_duct0.69611310

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.82817052
2Mitochondrial inheritance (HP:0001427)4.55807343
3Abnormal mitochondria in muscle tissue (HP:0008316)4.27514878
4Progressive macrocephaly (HP:0004481)4.13927317
5Acute encephalopathy (HP:0006846)4.04353079
6Increased hepatocellular lipid droplets (HP:0006565)4.04006349
7Increased CSF lactate (HP:0002490)3.95391438
8Hepatocellular necrosis (HP:0001404)3.91299435
9Lipid accumulation in hepatocytes (HP:0006561)3.71398246
103-Methylglutaconic aciduria (HP:0003535)3.71299742
11Congenital, generalized hypertrichosis (HP:0004540)3.51430518
12Hepatic necrosis (HP:0002605)3.51192353
13Pancreatic cysts (HP:0001737)3.48939879
14Cerebral edema (HP:0002181)3.22619572
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21708337
16Renal Fanconi syndrome (HP:0001994)3.15790544
17Abnormal rod and cone electroretinograms (HP:0008323)3.09034696
18Pancreatic fibrosis (HP:0100732)3.01019014
19True hermaphroditism (HP:0010459)3.00756798
20Abnormal number of erythroid precursors (HP:0012131)3.00667078
21Reticulocytopenia (HP:0001896)2.97478905
22Abnormality of cells of the erythroid lineage (HP:0012130)2.94754468
23Molar tooth sign on MRI (HP:0002419)2.85963999
24Abnormality of midbrain morphology (HP:0002418)2.85963999
25Optic disc pallor (HP:0000543)2.84110148
26Congenital stationary night blindness (HP:0007642)2.80036474
27Type II lissencephaly (HP:0007260)2.75353052
28Hypothermia (HP:0002045)2.71007740
29Aplastic anemia (HP:0001915)2.69851781
30Methylmalonic acidemia (HP:0002912)2.69021312
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68938786
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68938786
33Increased intramyocellular lipid droplets (HP:0012240)2.68081221
34Macrocytic anemia (HP:0001972)2.66713141
35Exertional dyspnea (HP:0002875)2.63457024
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61659147
37IgG deficiency (HP:0004315)2.59421776
38Nephronophthisis (HP:0000090)2.50339078
39Abolished electroretinogram (ERG) (HP:0000550)2.48422870
40Severe combined immunodeficiency (HP:0004430)2.40231581
41Attenuation of retinal blood vessels (HP:0007843)2.39458269
42Decreased central vision (HP:0007663)2.38769351
43Lactic acidosis (HP:0003128)2.38729499
44Constricted visual fields (HP:0001133)2.35212796
45Increased serum lactate (HP:0002151)2.30652231
46Hyperglycinemia (HP:0002154)2.27640732
47Lethargy (HP:0001254)2.25249327
48Respiratory failure (HP:0002878)2.24956945
49Hypoproteinemia (HP:0003075)2.21895389
50Thyroiditis (HP:0100646)2.20104644
51Increased muscle lipid content (HP:0009058)2.19508806
52Pendular nystagmus (HP:0012043)2.15927193
53Pallor (HP:0000980)2.15041683
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14020369
55Type I transferrin isoform profile (HP:0003642)2.11454911
56Medial flaring of the eyebrow (HP:0010747)2.11426169
57Methylmalonic aciduria (HP:0012120)2.11354937
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.08733442
59Absent/shortened dynein arms (HP:0200106)2.08733442
60Generalized aminoaciduria (HP:0002909)2.07972158
61Abnormality of renal resorption (HP:0011038)2.07575300
62Leukodystrophy (HP:0002415)2.06260127
63Abnormality of the renal medulla (HP:0100957)2.05072026
64Elevated erythrocyte sedimentation rate (HP:0003565)2.04871306
65Keratoconus (HP:0000563)2.04682453
66Increased corneal curvature (HP:0100692)2.04682453
67Sclerocornea (HP:0000647)2.00555185
68Retinal dysplasia (HP:0007973)2.00001631
69Cystic liver disease (HP:0006706)1.98435027
70Abnormality of urine glucose concentration (HP:0011016)1.97587613
71Glycosuria (HP:0003076)1.97587613
72Absent thumb (HP:0009777)1.93577127
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.91587180
74Exercise intolerance (HP:0003546)1.91037718
75Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90727230
76Abnormality of the renal cortex (HP:0011035)1.90639351
77Abnormality of the phalanges of the 5th finger (HP:0004213)1.87986564
78Abnormal respiratory motile cilium morphology (HP:0005938)1.86199201
79Abnormal respiratory epithelium morphology (HP:0012253)1.86199201
80Concave nail (HP:0001598)1.85038286
81Pancytopenia (HP:0001876)1.84368855
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80689355
83Dicarboxylic aciduria (HP:0003215)1.80689355
84Abnormality of the prostate (HP:0008775)1.80623096
85Aplasia/hypoplasia of the uterus (HP:0008684)1.79607386
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78126287
87Respiratory difficulties (HP:0002880)1.78012981
88Combined immunodeficiency (HP:0005387)1.76373981
89Male pseudohermaphroditism (HP:0000037)1.75397588
90Abnormal protein glycosylation (HP:0012346)1.75100811
91Abnormal glycosylation (HP:0012345)1.75100811
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75100811
93Abnormal protein N-linked glycosylation (HP:0012347)1.75100811
94Cerebellar dysplasia (HP:0007033)1.74248238
95Abnormal respiratory motile cilium physiology (HP:0012261)1.73433583
96CNS demyelination (HP:0007305)1.73249194
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73209536
98Abnormality of alanine metabolism (HP:0010916)1.73209536
99Hyperalaninemia (HP:0003348)1.73209536
100Abnormal ciliary motility (HP:0012262)1.71386200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.79460282
2MAP4K23.58266859
3TLK13.21217566
4CDK193.17391753
5TXK3.04796933
6ZAK3.03357982
7FRK2.45093877
8TAOK32.44685886
9NUAK12.25492478
10BCKDK2.21438548
11KDR2.19461329
12VRK12.18885247
13ADRBK22.16731471
14GRK12.06412858
15WNK31.94419940
16TESK21.80261020
17MAP3K121.73495699
18BUB11.71713405
19PASK1.65927119
20WNK41.62053225
21BMPR21.58133343
22PINK11.44689551
23ERBB31.33549135
24KIT1.25865195
25BMPR1B1.24820033
26INSRR1.16272512
27SRPK11.13687301
28NME11.07241723
29GRK61.05599160
30STK161.05036079
31MAPK131.03045608
32MYLK1.02816843
33DYRK21.02321652
34SCYL21.01645166
35TEC0.98446544
36MST40.97690221
37FES0.90979304
38CSNK1G30.90398123
39SYK0.89100810
40TAF10.87171083
41ITK0.85961036
42OXSR10.85229049
43MAP3K40.80754256
44MUSK0.79737277
45IKBKB0.79468612
46RPS6KA50.78744781
47CSNK1G20.78739139
48LIMK10.78056634
49FGFR20.77507628
50DAPK30.77313885
51MAP2K70.75675568
52CDK80.75250255
53PHKG10.75170052
54PHKG20.75170052
55FLT30.74634262
56EPHA40.74600891
57MKNK10.73561766
58CSF1R0.72822908
59DAPK10.68623446
60CSNK1G10.67966975
61MAP4K10.66893114
62DAPK20.65957770
63ADRBK10.65475429
64PRKCE0.64601579
65GRK70.60850664
66LYN0.60222510
67OBSCN0.60159680
68PRKCQ0.59804046
69TRIM280.58061984
70CSNK1A1L0.53835151
71LCK0.52339570
72PIK3CG0.51810869
73PLK40.50815115
74ILK0.49664045
75PRKCG0.49561123
76AURKB0.48758236
77TGFBR10.47542558
78TIE10.47056764
79NEK20.46710668
80PRKACA0.46546032
81RPS6KA40.45190437
82PLK30.43174444
83CCNB10.42318256
84STK390.41996925
85GRK50.41392470
86CSNK2A20.40302801
87IGF1R0.39014148
88IKBKE0.37786061
89PLK20.37609009
90ROCK10.36962662
91STK38L0.36929907
92PIM10.36492149
93PRKCA0.36373458
94CSNK2A10.35910523
95MAPK150.35859765
96CAMKK20.35009940
97CSNK1A10.34539139
98ATR0.34006586
99TNK20.33712111
100AURKA0.32816599

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.49210633
2Ribosome_Homo sapiens_hsa030104.21382358
3Parkinsons disease_Homo sapiens_hsa050123.68185301
4Proteasome_Homo sapiens_hsa030503.38529985
5Asthma_Homo sapiens_hsa053102.93783139
6Protein export_Homo sapiens_hsa030602.59605537
7Alzheimers disease_Homo sapiens_hsa050102.46396243
8Huntingtons disease_Homo sapiens_hsa050162.41084870
9RNA polymerase_Homo sapiens_hsa030202.35941697
10Autoimmune thyroid disease_Homo sapiens_hsa053202.33808522
11Allograft rejection_Homo sapiens_hsa053302.31385689
12Graft-versus-host disease_Homo sapiens_hsa053322.25481287
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.19909009
14Type I diabetes mellitus_Homo sapiens_hsa049402.11731653
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10172052
16Cardiac muscle contraction_Homo sapiens_hsa042602.08499179
17Primary immunodeficiency_Homo sapiens_hsa053402.00806505
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96332447
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58533312
20Nitrogen metabolism_Homo sapiens_hsa009101.54008347
21Antigen processing and presentation_Homo sapiens_hsa046121.53835105
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.52525190
23Phototransduction_Homo sapiens_hsa047441.47352201
24Homologous recombination_Homo sapiens_hsa034401.43089202
25RNA degradation_Homo sapiens_hsa030181.33557578
26Rheumatoid arthritis_Homo sapiens_hsa053231.23090051
27Linoleic acid metabolism_Homo sapiens_hsa005911.22620013
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.21406920
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19333167
30Systemic lupus erythematosus_Homo sapiens_hsa053221.19024217
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17429266
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11054244
33Butanoate metabolism_Homo sapiens_hsa006501.04082170
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98465009
35Spliceosome_Homo sapiens_hsa030400.96653459
36Caffeine metabolism_Homo sapiens_hsa002320.96612342
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96522591
38Fanconi anemia pathway_Homo sapiens_hsa034600.96398554
39Tryptophan metabolism_Homo sapiens_hsa003800.96226608
40Peroxisome_Homo sapiens_hsa041460.96046633
41Basal transcription factors_Homo sapiens_hsa030220.95202203
42Mismatch repair_Homo sapiens_hsa034300.94320384
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92637720
44Hematopoietic cell lineage_Homo sapiens_hsa046400.90400226
45Pyrimidine metabolism_Homo sapiens_hsa002400.88976341
46Purine metabolism_Homo sapiens_hsa002300.88624507
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84642680
48Chemical carcinogenesis_Homo sapiens_hsa052040.82758427
49Collecting duct acid secretion_Homo sapiens_hsa049660.81677745
50Propanoate metabolism_Homo sapiens_hsa006400.81634992
51Olfactory transduction_Homo sapiens_hsa047400.80809145
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80761281
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78286464
54One carbon pool by folate_Homo sapiens_hsa006700.76381540
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71377858
56Nucleotide excision repair_Homo sapiens_hsa034200.69799246
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69527328
58Staphylococcus aureus infection_Homo sapiens_hsa051500.67598910
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66027346
60Viral myocarditis_Homo sapiens_hsa054160.64691731
61Taste transduction_Homo sapiens_hsa047420.64271401
62Nicotine addiction_Homo sapiens_hsa050330.63392198
63Arachidonic acid metabolism_Homo sapiens_hsa005900.63364594
64Retinol metabolism_Homo sapiens_hsa008300.62536098
65Metabolic pathways_Homo sapiens_hsa011000.62083980
66DNA replication_Homo sapiens_hsa030300.61508045
67RNA transport_Homo sapiens_hsa030130.59710463
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.58231229
69Regulation of autophagy_Homo sapiens_hsa041400.56568923
70Base excision repair_Homo sapiens_hsa034100.54349649
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54003878
72Ether lipid metabolism_Homo sapiens_hsa005650.52716516
73Sulfur metabolism_Homo sapiens_hsa009200.49821661
74Glutathione metabolism_Homo sapiens_hsa004800.48995052
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47585634
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43131263
77Fat digestion and absorption_Homo sapiens_hsa049750.42731035
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42154585
79beta-Alanine metabolism_Homo sapiens_hsa004100.41436739
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.37381919
81Tyrosine metabolism_Homo sapiens_hsa003500.34294854
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33933130
83Morphine addiction_Homo sapiens_hsa050320.33412364
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33149027
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32829912
86Alcoholism_Homo sapiens_hsa050340.32724915
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.32693507
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32194106
89Folate biosynthesis_Homo sapiens_hsa007900.31588346
90GABAergic synapse_Homo sapiens_hsa047270.30735257
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30302408
92Selenocompound metabolism_Homo sapiens_hsa004500.30123437
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29939034
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25568087
95Vitamin digestion and absorption_Homo sapiens_hsa049770.22349295
96Salivary secretion_Homo sapiens_hsa049700.20734487
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20148989
98Fatty acid elongation_Homo sapiens_hsa000620.19781792
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19382728
100Leishmaniasis_Homo sapiens_hsa051400.19116647

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