RPS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal large subunit biogenesis (GO:0042273)7.64168841
2* protein targeting to membrane (GO:0006612)7.37039114
3* mRNA catabolic process (GO:0006402)6.39544500
4* translation (GO:0006412)6.32303943
5ribonucleoprotein complex biogenesis (GO:0022613)5.91917916
6* RNA catabolic process (GO:0006401)5.82007547
7ATP synthesis coupled proton transport (GO:0015986)5.25227948
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.25227948
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.18715507
10* establishment of protein localization to membrane (GO:0090150)4.96411936
11cellular component biogenesis (GO:0044085)4.64780636
12folic acid-containing compound biosynthetic process (GO:0009396)4.43160894
13* protein targeting (GO:0006605)4.42794582
14* viral transcription (GO:0019083)4.31691008
15ribosomal small subunit assembly (GO:0000028)4.28620390
16* establishment of protein localization to organelle (GO:0072594)4.27343718
17chaperone-mediated protein transport (GO:0072321)4.24906913
18regulation of translational fidelity (GO:0006450)4.14538855
19* translational termination (GO:0006415)4.12727258
20DNA unwinding involved in DNA replication (GO:0006268)4.04670770
21* protein localization to membrane (GO:0072657)3.90480446
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90404359
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90404359
24* translational elongation (GO:0006414)3.82440840
25rRNA processing (GO:0006364)3.78732872
26pentose-phosphate shunt (GO:0006098)3.76416333
27maternal placenta development (GO:0001893)3.72338536
28heterochromatin organization (GO:0070828)3.71664148
29positive regulation of histone deacetylation (GO:0031065)3.65392811
30rRNA metabolic process (GO:0016072)3.64799960
31* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62155100
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58204894
33regulation of translational termination (GO:0006449)3.53614361
34negative regulation of RNA splicing (GO:0033119)3.48306025
35protein localization to kinetochore (GO:0034501)3.47195007
36ribosomal small subunit biogenesis (GO:0042274)3.42291151
37antigen processing and presentation of endogenous antigen (GO:0019883)3.41728767
38* translational initiation (GO:0006413)3.37786854
39respiratory electron transport chain (GO:0022904)3.37103315
40regulation of activation of Janus kinase activity (GO:0010533)3.34984542
41nucleotide salvage (GO:0043173)3.34818223
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.30951259
433-UTR-mediated mRNA stabilization (GO:0070935)3.29361763
44electron transport chain (GO:0022900)3.28995190
45mRNA stabilization (GO:0048255)3.27298921
46RNA stabilization (GO:0043489)3.27298921
47NADPH regeneration (GO:0006740)3.26423283
48pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.25743344
49T cell apoptotic process (GO:0070231)3.23012692
50* viral life cycle (GO:0019058)3.20508884
51* cellular component disassembly (GO:0022411)3.20065896
52* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20001606
53* cellular protein complex disassembly (GO:0043624)3.17100388
54IMP biosynthetic process (GO:0006188)3.16807586
55pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.14215107
56* protein targeting to ER (GO:0045047)3.13858407
57formation of translation preinitiation complex (GO:0001731)3.11923417
58apoptotic process involved in morphogenesis (GO:0060561)3.11749639
59* protein localization to organelle (GO:0033365)3.11079016
60* protein complex disassembly (GO:0043241)3.07140382
61* cotranslational protein targeting to membrane (GO:0006613)3.05849671
62nucleoside salvage (GO:0043174)3.04509492
63negative regulation of phagocytosis (GO:0050765)3.03983647
64pyrimidine-containing compound salvage (GO:0008655)3.03983129
65pyrimidine nucleoside salvage (GO:0043097)3.03983129
66positive regulation of SMAD protein import into nucleus (GO:0060391)3.02551644
67protein localization to chromosome, centromeric region (GO:0071459)3.01964370
68mitotic nuclear envelope disassembly (GO:0007077)3.01792878
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01711512
70negative regulation of mRNA processing (GO:0050686)3.01358180
71* establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99231211
72maturation of SSU-rRNA (GO:0030490)2.97356240
73peptidyl-lysine dimethylation (GO:0018027)2.97038274
74regulation of posttranscriptional gene silencing (GO:0060147)2.96654062
75regulation of gene silencing by miRNA (GO:0060964)2.96654062
76regulation of gene silencing by RNA (GO:0060966)2.96654062
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92847689
78pre-miRNA processing (GO:0031054)2.92757312
79pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92574996
80COPI coating of Golgi vesicle (GO:0048205)2.90698077
81Golgi transport vesicle coating (GO:0048200)2.90698077
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89754742
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89611915
84regulation of protein heterodimerization activity (GO:0043497)2.88916987
85pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88577489
86ATP biosynthetic process (GO:0006754)2.88208350
87CTP biosynthetic process (GO:0006241)2.87471967
88CTP metabolic process (GO:0046036)2.87471967
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87036632
90nuclear pore organization (GO:0006999)2.85116925
91negative regulation of mRNA metabolic process (GO:1903312)2.85098497
92negative regulation of histone methylation (GO:0031061)2.82705071
93* protein localization to endoplasmic reticulum (GO:0070972)2.82352639
94nuclear envelope disassembly (GO:0051081)2.81928835
95membrane disassembly (GO:0030397)2.81928835
96regulation of hippo signaling (GO:0035330)2.81326516
97peptidyl-arginine omega-N-methylation (GO:0035247)2.81231527
98IMP metabolic process (GO:0046040)2.81127553
99glucocorticoid receptor signaling pathway (GO:0042921)2.81033356
100positive regulation of nuclease activity (GO:0032075)2.79631095
101dosage compensation (GO:0007549)2.79275271
102ribosome biogenesis (GO:0042254)2.77397928
103lymphocyte apoptotic process (GO:0070227)2.76052719
104regulation of SMAD protein import into nucleus (GO:0060390)2.75213645
105* macromolecular complex disassembly (GO:0032984)2.75111646
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.75060835
107spliceosomal tri-snRNP complex assembly (GO:0000244)2.72802914
108nuclear pore complex assembly (GO:0051292)2.70740451
109pentose metabolic process (GO:0019321)2.70543980
110positive regulation of protein deacetylation (GO:0090312)2.69702367
111protein heterotrimerization (GO:0070208)2.69440265
112trophectodermal cell differentiation (GO:0001829)2.68728016
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.68445222
114NADH dehydrogenase complex assembly (GO:0010257)2.68445222
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68445222
116skin morphogenesis (GO:0043589)2.67639064
117pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.66695076
118purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66210919
119* gene expression (GO:0010467)2.65814897
120viral protein processing (GO:0019082)2.65474442
121sister chromatid segregation (GO:0000819)2.63867256
122DNA strand elongation involved in DNA replication (GO:0006271)2.62956789
123intracellular estrogen receptor signaling pathway (GO:0030520)2.62903086
124glucose catabolic process (GO:0006007)2.62381154
125DNA duplex unwinding (GO:0032508)2.62182314
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62062171
127negative regulation of erythrocyte differentiation (GO:0045647)2.62031346
128regulation of nuclease activity (GO:0032069)2.60636160
129pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.59961760
130UMP metabolic process (GO:0046049)2.59961760
131pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.59961760
132UMP biosynthetic process (GO:0006222)2.59961760
133purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59646254
134regulation of gamma-delta T cell differentiation (GO:0045586)2.57577987
135DNA geometric change (GO:0032392)2.57526807
136response to laminar fluid shear stress (GO:0034616)2.57194040
137protein targeting to mitochondrion (GO:0006626)2.56883037
138negative regulation of fatty acid transport (GO:2000192)2.56848089
139mitochondrial respiratory chain complex assembly (GO:0033108)2.56813325
140oxidative phosphorylation (GO:0006119)2.56292108
141mitotic sister chromatid segregation (GO:0000070)2.55303306
142protein complex biogenesis (GO:0070271)2.55264114
143alternative mRNA splicing, via spliceosome (GO:0000380)2.54290332
144DNA strand elongation (GO:0022616)2.53414487
145pyrimidine nucleotide catabolic process (GO:0006244)2.52041606
146cell-substrate junction assembly (GO:0007044)2.51605937
147tetrahydrofolate metabolic process (GO:0046653)2.47684048
148ncRNA 3-end processing (GO:0043628)2.46700441
149ncRNA processing (GO:0034470)2.46295665
150negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46266874
151epithelial cell-cell adhesion (GO:0090136)2.46266643
152* nuclear-transcribed mRNA catabolic process (GO:0000956)2.45598264
153telomere maintenance via semi-conservative replication (GO:0032201)2.44963554
154chromatin assembly (GO:0031497)2.43926897
155negative regulation of cell size (GO:0045792)2.43744753
156peptidyl-arginine N-methylation (GO:0035246)2.43583726
157peptidyl-arginine methylation (GO:0018216)2.43583726
158nucleoside triphosphate biosynthetic process (GO:0009142)2.43511976
159establishment of apical/basal cell polarity (GO:0035089)2.42733693
160nuclear envelope organization (GO:0006998)2.42174327
161regulation of histone H3-K9 methylation (GO:0051570)2.42018070
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40951929
163RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40951929
164endoplasmic reticulum unfolded protein response (GO:0030968)2.40372101
165myeloid cell homeostasis (GO:0002262)2.39894865
166regulation of mRNA stability (GO:0043488)2.39663936
167peptidyl-histidine modification (GO:0018202)2.38533600
168ribonucleoprotein complex assembly (GO:0022618)2.37690539
169establishment of protein localization to mitochondrion (GO:0072655)2.36900883
170ribonucleoside monophosphate biosynthetic process (GO:0009156)2.28873724
171nucleoside monophosphate biosynthetic process (GO:0009124)2.28602066
172DNA replication checkpoint (GO:0000076)2.26053346
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.25441095
174* single-organism cellular localization (GO:1902580)2.24317708
175purine nucleoside monophosphate biosynthetic process (GO:0009127)2.23757930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.43211860
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.56139671
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.84864868
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.81371841
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.67984793
6* MYC_22102868_ChIP-Seq_BL_Human3.54435483
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26829322
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.20828637
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93366015
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80870028
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.75507198
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.67493666
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63123394
14VDR_21846776_ChIP-Seq_THP-1_Human2.60054940
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52199121
16* MYC_18555785_ChIP-Seq_MESCs_Mouse2.48157744
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.37482072
18* TTF2_22483619_ChIP-Seq_HELA_Human2.32753193
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25495126
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22258325
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20267194
22* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18865248
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95486001
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.95425101
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93204457
26* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.90608137
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89843408
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88133545
29TCF7_22412390_ChIP-Seq_EML_Mouse1.85340663
30ZNF263_19887448_ChIP-Seq_K562_Human1.85140528
31CLOCK_20551151_ChIP-Seq_293T_Human1.80447903
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80170915
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.78378628
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76290229
35KDM2B_26808549_Chip-Seq_DND41_Human1.74522337
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.73303645
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69095705
38DCP1A_22483619_ChIP-Seq_HELA_Human1.68189629
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.68068006
40* XRN2_22483619_ChIP-Seq_HELA_Human1.65805890
41* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65520603
42MAF_26560356_Chip-Seq_TH1_Human1.64471405
43VDR_23849224_ChIP-Seq_CD4+_Human1.59285155
44UTX_26944678_Chip-Seq_JUKART_Human1.57238518
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54153712
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53841959
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52524071
48AR_21909140_ChIP-Seq_LNCAP_Human1.50837595
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49001732
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48132051
51* GABP_19822575_ChIP-Seq_HepG2_Human1.48089189
52ATF3_27146783_Chip-Seq_COLON_Human1.47542651
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46515121
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46453654
55RACK7_27058665_Chip-Seq_MCF-7_Human1.45267527
56LXR_22292898_ChIP-Seq_THP-1_Human1.45185855
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44063684
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43687865
59* VDR_24763502_ChIP-Seq_THP-1_Human1.40997300
60CIITA_25753668_ChIP-Seq_RAJI_Human1.40708285
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40609883
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38244043
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36932487
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.36604654
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34834649
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31171658
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30733617
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30597717
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30435101
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29835217
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29521462
72* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29330815
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29071952
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28849622
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28660466
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28443375
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28260497
78NCOR1_26117541_ChIP-Seq_K562_Human1.27219179
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25509607
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.24835003
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24755273
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23158103
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.21955115
84* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21835215
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21833109
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21812688
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21812688
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21812688
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21467362
90* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21435274
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19329156
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19109061
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18679704
94* ELK1_19687146_ChIP-ChIP_HELA_Human1.18298154
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17895251
96MAF_26560356_Chip-Seq_TH2_Human1.15524522
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15269142
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.14576196
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14011737
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13559792
101* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13491873
102KDM5A_27292631_Chip-Seq_BREAST_Human1.12800267
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11868861
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10679898
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10457236
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09481971
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.09465649
108* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09295915
109MYB_26560356_Chip-Seq_TH2_Human1.09210943
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08894793
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07232660
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06846848
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06603953
114SCL_19346495_ChIP-Seq_HPC-7_Human1.06455124
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05657716
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.05516665
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04736919
118ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04289689
119MYB_26560356_Chip-Seq_TH1_Human1.04164811
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03547894
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01862213
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.01783209
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.01736758
124* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01016307
125TFEB_21752829_ChIP-Seq_HELA_Human1.00733589
126CHD1_26751641_Chip-Seq_LNCaP_Human0.99587662
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98936322
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.98741199
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98709021
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98583975
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98334922
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98229123
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97991767
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97213609
135P68_20966046_ChIP-Seq_HELA_Human0.97133536
136* FOXP1_21924763_ChIP-Seq_HESCs_Human0.96754161
137GATA6_25053715_ChIP-Seq_YYC3_Human0.96582436
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96582055
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96572482
140* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95793886
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94573817
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94094549
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93878472
144* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93758833
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.93636898
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93272123
147TP53_22127205_ChIP-Seq_IMR90_Human0.92627683
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91958437
149SPI1_23547873_ChIP-Seq_NB4_Human0.91755605
150PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91516801
151OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91477298
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91278919
153MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90662058
154POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89596666
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.89220844
156FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88901903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.98411273
2MP0006292_abnormal_olfactory_placode3.39263114
3MP0010352_gastrointestinal_tract_polyps3.13783242
4MP0010234_abnormal_vibrissa_follicle2.64439122
5MP0002163_abnormal_gland_morphology2.60900224
6MP0005076_abnormal_cell_differentiation2.45080864
7MP0003300_gastrointestinal_ulcer2.41326266
8MP0003566_abnormal_cell_adhesion2.40381036
9MP0008438_abnormal_cutaneous_collagen2.21700670
10MP0004957_abnormal_blastocyst_morpholog2.14267376
11MP0003303_peritoneal_inflammation2.09635004
12MP0003136_yellow_coat_color2.09140332
13MP0001849_ear_inflammation2.05397517
14MP0003693_abnormal_embryo_hatching2.04802496
15MP0003806_abnormal_nucleotide_metabolis2.00118159
16MP0009379_abnormal_foot_pigmentation10.9556943
17MP0002132_abnormal_respiratory_system1.98931315
18MP0003111_abnormal_nucleus_morphology1.97126155
19MP0010307_abnormal_tumor_latency1.96807608
20MP0009278_abnormal_bone_marrow1.91490601
21MP0006054_spinal_hemorrhage1.82027902
22MP0005275_abnormal_skin_tensile1.74525271
23MP0001730_embryonic_growth_arrest1.70489491
24MP0002877_abnormal_melanocyte_morpholog1.69548059
25MP0003077_abnormal_cell_cycle1.68917027
26MP0002095_abnormal_skin_pigmentation1.65808379
27MP0000733_abnormal_muscle_development1.65579396
28MP0002396_abnormal_hematopoietic_system1.64812092
29MP0003186_abnormal_redox_activity1.64057730
30MP0004185_abnormal_adipocyte_glucose1.62735679
31MP0005023_abnormal_wound_healing1.62258223
32MP0004197_abnormal_fetal_growth/weight/1.57844000
33MP0003646_muscle_fatigue1.57663301
34MP0000537_abnormal_urethra_morphology1.56948565
35MP0004808_abnormal_hematopoietic_stem1.56560914
36MP0000350_abnormal_cell_proliferation1.54427622
37MP0000678_abnormal_parathyroid_gland1.54287322
38MP0008932_abnormal_embryonic_tissue1.47589299
39MP0009053_abnormal_anal_canal1.44441201
40MP0005408_hypopigmentation1.43505927
41MP0000685_abnormal_immune_system1.42461180
42MP0000566_synostosis1.40682959
43MP0008995_early_reproductive_senescence1.40523256
44MP0008789_abnormal_olfactory_epithelium1.31166234
45MP0003786_premature_aging1.30955185
46MP0003567_abnormal_fetal_cardiomyocyte1.30627044
47MP0000490_abnormal_crypts_of1.30517539
48MP0010094_abnormal_chromosome_stability1.27805024
49MP0004381_abnormal_hair_follicle1.26763473
50MP0002938_white_spotting1.26659926
51MP0009840_abnormal_foam_cell1.25983862
52MP0002086_abnormal_extraembryonic_tissu1.24202978
53MP0000049_abnormal_middle_ear1.23939678
54MP0003984_embryonic_growth_retardation1.23787221
55MP0002277_abnormal_respiratory_mucosa1.23347436
56MP0005671_abnormal_response_to1.22481510
57MP0002088_abnormal_embryonic_growth/wei1.21873773
58MP0005380_embryogenesis_phenotype1.20858552
59MP0001672_abnormal_embryogenesis/_devel1.20858552
60MP0002084_abnormal_developmental_patter1.18670742
61MP0002080_prenatal_lethality1.18281562
62MP0005075_abnormal_melanosome_morpholog1.17818442
63MP0008007_abnormal_cellular_replicative1.16377756
64MP0000858_altered_metastatic_potential1.16022082
65MP0009333_abnormal_splenocyte_physiolog1.15922654
66MP0004947_skin_inflammation1.15920853
67MP0001697_abnormal_embryo_size1.14488643
68MP0002085_abnormal_embryonic_tissue1.12623838
69MP0005397_hematopoietic_system_phenotyp1.11382326
70MP0001545_abnormal_hematopoietic_system1.11382326
71MP0005501_abnormal_skin_physiology1.10818799
72MP0003315_abnormal_perineum_morphology1.09127943
73MP0001293_anophthalmia1.08788969
74MP0002398_abnormal_bone_marrow1.08578105
75MP0003436_decreased_susceptibility_to1.08079584
76MP0001346_abnormal_lacrimal_gland1.07893791
77MP0001663_abnormal_digestive_system1.07096982
78MP0005174_abnormal_tail_pigmentation1.06660792
79MP0008058_abnormal_DNA_repair1.06481922
80MP0002060_abnormal_skin_morphology1.04975042
81MP0010155_abnormal_intestine_physiology1.04518529
82MP0003453_abnormal_keratinocyte_physiol1.04510958
83MP0002420_abnormal_adaptive_immunity1.04183568
84MP0002019_abnormal_tumor_incidence1.03763688
85MP0001919_abnormal_reproductive_system1.03065560
86MP0001819_abnormal_immune_cell1.02560513
87MP0002653_abnormal_ependyma_morphology1.01534958
88MP0005666_abnormal_adipose_tissue1.01236709
89MP0009672_abnormal_birth_weight1.01174415
90MP0003091_abnormal_cell_migration1.00817543
91MP0000477_abnormal_intestine_morphology1.00724309
92MP0000750_abnormal_muscle_regeneration0.99975934
93MP0002722_abnormal_immune_system0.99857719
94MP0000372_irregular_coat_pigmentation0.98891775
95MP0002796_impaired_skin_barrier0.98367232
96MP0005389_reproductive_system_phenotype0.98320177
97MP0001915_intracranial_hemorrhage0.98297311
98MP0000703_abnormal_thymus_morphology0.97881343
99MP0005025_abnormal_response_to0.97415930
100MP0006036_abnormal_mitochondrial_physio0.97252339
101MP0002249_abnormal_larynx_morphology0.96220366
102MP0001800_abnormal_humoral_immune0.95679288
103MP0002160_abnormal_reproductive_system0.95575663
104MP0003763_abnormal_thymus_physiology0.95280399
105MP0005379_endocrine/exocrine_gland_phen0.94822595
106MP0010030_abnormal_orbit_morphology0.94252251
107MP0005499_abnormal_olfactory_system0.92857376
108MP0005394_taste/olfaction_phenotype0.92857376
109MP0001348_abnormal_lacrimal_gland0.92850094
110MP0003279_aneurysm0.92757104
111MP0002723_abnormal_immune_serum0.92518352
112MP0002210_abnormal_sex_determination0.92064008
113MP0003123_paternal_imprinting0.92020228
114MP0005375_adipose_tissue_phenotype0.91400684
115MP0000689_abnormal_spleen_morphology0.91024311
116MP0006082_CNS_inflammation0.90941370
117MP0003878_abnormal_ear_physiology0.90364998
118MP0005377_hearing/vestibular/ear_phenot0.90364998
119MP0008961_abnormal_basal_metabolism0.89344964
120MP0000465_gastrointestinal_hemorrhage0.89312454
121MP0005000_abnormal_immune_tolerance0.87945852
122MP0003115_abnormal_respiratory_system0.87762692
123MP0003448_altered_tumor_morphology0.87319510
124MP0002697_abnormal_eye_size0.86775652
125MP0005623_abnormal_meninges_morphology0.86690028
126MP0005387_immune_system_phenotype0.86619247
127MP0001790_abnormal_immune_system0.86619247
128MP0004264_abnormal_extraembryonic_tissu0.86372628
129MP0003191_abnormal_cellular_cholesterol0.85602457
130MP0005464_abnormal_platelet_physiology0.84781294
131MP0001881_abnormal_mammary_gland0.84685937
132MP0000467_abnormal_esophagus_morphology0.83371648
133MP0001835_abnormal_antigen_presentation0.82771632
134MP0002429_abnormal_blood_cell0.82204230
135MP0002405_respiratory_system_inflammati0.82163553
136MP0002092_abnormal_eye_morphology0.82162961
137MP0001958_emphysema0.82152153
138MP0002166_altered_tumor_susceptibility0.82012118
139MP0001243_abnormal_dermal_layer0.81498521
140MP0002089_abnormal_postnatal_growth/wei0.81155808
141MP0004858_abnormal_nervous_system0.81031682
142MP0000428_abnormal_craniofacial_morphol0.80683262
143MP0002111_abnormal_tail_morphology0.79717839
144MP0003938_abnormal_ear_development0.79671209
145MP0000313_abnormal_cell_death0.79544070
146MP0009931_abnormal_skin_appearance0.79289040
147MP0002925_abnormal_cardiovascular_devel0.78986713
148MP0002452_abnormal_antigen_presenting0.78439011
149MP0001216_abnormal_epidermal_layer0.78322247
150MP0010630_abnormal_cardiac_muscle0.77363204
151MP0004272_abnormal_basement_membrane0.77010801
152MP0001873_stomach_inflammation0.76734788
153MP0002234_abnormal_pharynx_morphology0.76663089
154MP0000343_altered_response_to0.76482838
155MP0000716_abnormal_immune_system0.75273129
156MP0005381_digestive/alimentary_phenotyp0.75119541
157MP0003283_abnormal_digestive_organ0.73276861
158MP0001853_heart_inflammation0.72824678
159MP0000762_abnormal_tongue_morphology0.72252994

Predicted human phenotypes

RankGene SetZ-score
1Macrocytic anemia (HP:0001972)7.92715850
2Pallor (HP:0000980)7.03820523
3Acute necrotizing encephalopathy (HP:0006965)4.08792456
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.06808910
5Protrusio acetabuli (HP:0003179)3.97371393
6Abnormal mitochondria in muscle tissue (HP:0008316)3.85290649
7Increased hepatocellular lipid droplets (HP:0006565)3.71351154
83-Methylglutaconic aciduria (HP:0003535)3.40756471
9Acute encephalopathy (HP:0006846)3.37653197
10Mitochondrial inheritance (HP:0001427)3.35485693
11Abnormal hemoglobin (HP:0011902)3.30457430
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25916058
13Lipid accumulation in hepatocytes (HP:0006561)3.19550156
14Increased intramyocellular lipid droplets (HP:0012240)3.17679782
15Respiratory difficulties (HP:0002880)3.14223622
16Progressive macrocephaly (HP:0004481)3.09341709
17Partial duplication of thumb phalanx (HP:0009944)3.08511197
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05132351
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05132351
20Partial duplication of the phalanx of hand (HP:0009999)3.03524665
21Hyperacusis (HP:0010780)3.01947136
22Cerebral aneurysm (HP:0004944)2.97335949
23Increased CSF lactate (HP:0002490)2.95302825
24Depressed nasal ridge (HP:0000457)2.94861740
25Absent thumb (HP:0009777)2.93943730
26Ankle contracture (HP:0006466)2.92535111
2711 pairs of ribs (HP:0000878)2.91811201
28Renal Fanconi syndrome (HP:0001994)2.83572717
29Shallow orbits (HP:0000586)2.82100036
30Increased muscle lipid content (HP:0009058)2.74425422
31Premature rupture of membranes (HP:0001788)2.73601429
32Microvesicular hepatic steatosis (HP:0001414)2.73057752
33Increased density of long bones (HP:0006392)2.72881389
34Migraine (HP:0002076)2.70487659
35Ulnar bowing (HP:0003031)2.65352241
36Thick lower lip vermilion (HP:0000179)2.65051208
37Stenosis of the external auditory canal (HP:0000402)2.61138772
38Selective tooth agenesis (HP:0001592)2.54337494
39Pseudobulbar signs (HP:0002200)2.53520159
40Atrophic scars (HP:0001075)2.49427435
41Genu recurvatum (HP:0002816)2.46051311
42Hypoplasia of the radius (HP:0002984)2.45935894
43Rectal prolapse (HP:0002035)2.43413992
44Abnormality of cells of the erythroid lineage (HP:0012130)2.42868939
45Cerebral edema (HP:0002181)2.42084050
46Ependymoma (HP:0002888)2.41022607
47Thrombocytosis (HP:0001894)2.40107656
48Reticulocytopenia (HP:0001896)2.36394098
49Exertional dyspnea (HP:0002875)2.34406040
50Spastic diplegia (HP:0001264)2.34139087
51Progressive muscle weakness (HP:0003323)2.32130452
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31102369
53Triphalangeal thumb (HP:0001199)2.29387946
54Hypoplasia of the pons (HP:0012110)2.27900813
55Cellulitis (HP:0100658)2.25452237
56Mitral valve prolapse (HP:0001634)2.19904684
57Abnormality of the parietal bone (HP:0002696)2.18273243
58Distal upper limb amyotrophy (HP:0007149)2.16923702
59Upper limb amyotrophy (HP:0009129)2.16923702
60Bladder diverticulum (HP:0000015)2.16066880
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.15759429
62Aplastic anemia (HP:0001915)2.13301947
63Multiple enchondromatosis (HP:0005701)2.12039863
64Verrucae (HP:0200043)2.11432723
65Papilloma (HP:0012740)2.11432723
66Duplication of thumb phalanx (HP:0009942)2.11294117
67Dilatation of the ascending aorta (HP:0005111)2.10950209
68Peritonitis (HP:0002586)2.10425090
69Hand muscle atrophy (HP:0009130)2.10087433
70Back pain (HP:0003418)2.09317356
71Exercise intolerance (HP:0003546)2.09030818
72Thin bony cortex (HP:0002753)2.08155636
73Dysphonia (HP:0001618)2.07703022
74Cervical subluxation (HP:0003308)2.07034904
75Bowel diverticulosis (HP:0005222)2.06605390
76Testicular atrophy (HP:0000029)2.06513272
77Abnormality of the calcaneus (HP:0008364)2.06461472
78Hepatocellular necrosis (HP:0001404)2.06032948
79Aortic aneurysm (HP:0004942)2.05423043
80Abnormality of reticulocytes (HP:0004312)2.05341930
81High pitched voice (HP:0001620)2.04955676
82Ragged-red muscle fibers (HP:0003200)2.04595948
83Aneurysm (HP:0002617)2.02259988
84Basal cell carcinoma (HP:0002671)2.01440832
85Slender build (HP:0001533)2.01293513
86Colon cancer (HP:0003003)1.99373735
87Abnormal number of erythroid precursors (HP:0012131)1.97612686
88Nasal polyposis (HP:0100582)1.97116518
89Cleft eyelid (HP:0000625)1.95483381
90Achilles tendon contracture (HP:0001771)1.95219100
91Abnormality of the peritoneum (HP:0002585)1.94666767
92Abnormality of the pons (HP:0007361)1.94538003
93Milia (HP:0001056)1.93988542
94Deviation of the thumb (HP:0009603)1.92975670
95Panhypogammaglobulinemia (HP:0003139)1.90678647
96Chronic otitis media (HP:0000389)1.89866790
97Deviation of the hallux (HP:0010051)1.89732667
98Lactic acidosis (HP:0003128)1.88713187
99Progressive external ophthalmoplegia (HP:0000590)1.88007988
100Abnormal platelet volume (HP:0011876)1.87927528
101Reticulocytosis (HP:0001923)1.87875085
102Proximal placement of thumb (HP:0009623)1.87517373
103Hallux valgus (HP:0001822)1.86649639
104Bowed forearm bones (HP:0003956)1.86149590
105Bowing of the arm (HP:0006488)1.86149590
106Hepatic necrosis (HP:0002605)1.86080434
107Abnormality of the nasal mucosa (HP:0000433)1.85717824
108Neoplasm of head and neck (HP:0012288)1.84783996
109Esophageal neoplasm (HP:0100751)1.84783996
110Increased nuchal translucency (HP:0010880)1.83103421
111Increased connective tissue (HP:0009025)1.82934602
112Metaphyseal cupping (HP:0003021)1.82707043
113Aortic dissection (HP:0002647)1.82484959
114Impulsivity (HP:0100710)1.82357009
115Renal duplication (HP:0000075)1.82173853
116Disproportionate tall stature (HP:0001519)1.81532039
117Interstitial pulmonary disease (HP:0006530)1.81362781
118Abnormality of the Achilles tendon (HP:0005109)1.81344075
119Leukodystrophy (HP:0002415)1.81077081
120Septo-optic dysplasia (HP:0100842)1.79890329
121Sensory axonal neuropathy (HP:0003390)1.79632654
122Insomnia (HP:0100785)1.79137917
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78943567
124Short 4th metacarpal (HP:0010044)1.78943567
125Increased mean platelet volume (HP:0011877)1.78684471
126Broad metatarsal (HP:0001783)1.78455550
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.78260561
128Osteolytic defects of the hand bones (HP:0009699)1.78260561
129Malignant gastrointestinal tract tumors (HP:0006749)1.77081317
130Gastrointestinal carcinoma (HP:0002672)1.77081317
131Radial bowing (HP:0002986)1.76967126
132Chronic obstructive pulmonary disease (HP:0006510)1.76200001
133Obstructive lung disease (HP:0006536)1.76200001
134Respiratory failure (HP:0002878)1.76151737
135Abnormality of cochlea (HP:0000375)1.75387080
136Broad distal phalanx of finger (HP:0009836)1.75323412
137Enlarged penis (HP:0000040)1.75012050
138Increased serum lactate (HP:0002151)1.74899099
139Renovascular hypertension (HP:0100817)1.74710862
140Gastrointestinal inflammation (HP:0004386)1.74154432
141Hyperglycinemia (HP:0002154)1.73587791
142Vertebral clefting (HP:0008428)1.72724856
143Rib fusion (HP:0000902)1.72709583
144Astrocytoma (HP:0009592)1.72115316
145Abnormality of the astrocytes (HP:0100707)1.72115316
146Adenoma sebaceum (HP:0009720)1.72042574
147Angiofibromas (HP:0010615)1.72042574
148Broad palm (HP:0001169)1.71523341
149Increased IgE level (HP:0003212)1.71059947
150Ulnar deviation of the wrist (HP:0003049)1.70509577
151Elfin facies (HP:0004428)1.69678237
152Increased IgM level (HP:0003496)1.69130038
153Missing ribs (HP:0000921)1.69117543
154Bicuspid aortic valve (HP:0001647)1.68601016
155Horseshoe kidney (HP:0000085)1.68297580
156Blue sclerae (HP:0000592)1.67678679
157Microretrognathia (HP:0000308)1.67442793
158Birth length less than 3rd percentile (HP:0003561)1.67330238
159Nasolacrimal duct obstruction (HP:0000579)1.67326935
160Fragile skin (HP:0001030)1.67155169
161Trismus (HP:0000211)1.67096538
162Subacute progressive viral hepatitis (HP:0006572)1.66224227
163Cutaneous melanoma (HP:0012056)1.65483142
164Oral leukoplakia (HP:0002745)1.65129952
165Asplenia (HP:0001746)1.65076877
166Flat acetabular roof (HP:0003180)1.64429184
167Persistence of primary teeth (HP:0006335)1.64068927
168Abnormality of the 4th metacarpal (HP:0010012)1.63909101
169Abnormality of renal resorption (HP:0011038)1.63065331
170Paralysis (HP:0003470)1.62152959
171Eczematoid dermatitis (HP:0000976)1.62022170
172Type 1 muscle fiber predominance (HP:0003803)1.61432253
173Agammaglobulinemia (HP:0004432)1.60893371
174Parakeratosis (HP:0001036)1.60058121
175Hematochezia (HP:0002573)1.59920449
176Overriding aorta (HP:0002623)1.58385333
177Biliary tract neoplasm (HP:0100574)1.56768849
178Lymphangioma (HP:0100764)1.56400035
179Hyperphosphaturia (HP:0003109)1.56050468
180Short middle phalanx of the 5th finger (HP:0004220)1.53091455
181Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52764570
182Atresia of the external auditory canal (HP:0000413)1.51109890
183Tracheoesophageal fistula (HP:0002575)1.50374642
184Maternal diabetes (HP:0009800)1.50283045
185Pancytopenia (HP:0001876)1.49623757
186Hypertensive crisis (HP:0100735)1.48791596
187Aplasia/Hypoplasia of the spleen (HP:0010451)1.47760277
188Abnormality of DNA repair (HP:0003254)1.47233632
189Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46228635
190Premature ovarian failure (HP:0008209)1.45563075
191Seborrheic dermatitis (HP:0001051)1.44956729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.67357932
2TRIB34.49097555
3PKN24.25073632
4MAP3K103.01230112
5ERN12.92458214
6LIMK12.46536714
7CDK192.40827013
8LRRK22.31464102
9CDK82.06868595
10CDK122.05664794
11MAP4K12.01285000
12STK161.98936776
13PTK61.98579545
14RPS6KB21.98093267
15PRPF4B1.90834738
16TTN1.88638107
17PASK1.76642471
18NEK21.72594627
19IRAK41.70479822
20TLK11.63492198
21PAK41.58380538
22SIK11.58116492
23STK101.57847103
24ALK1.55091053
25CDC71.50727587
26MAP3K131.49399749
27SMG11.48581654
28EPHA21.48172459
29CDC42BPA1.45632593
30SCYL21.44160060
31BRSK11.43134326
32VRK21.41323117
33BMX1.37348824
34FLT31.32302616
35GRK61.31960087
36SRPK11.29926691
37CDK41.27646403
38PDGFRA1.26672968
39RIPK11.25479776
40MAP3K81.25459487
41NEK11.25326597
42CLK11.24083330
43TGFBR11.21846830
44MAP2K31.21815770
45AURKA1.17229134
46CDK61.13545552
47TSSK61.10871869
48CSNK2A21.09922702
49EPHB11.09372784
50BRAF1.08696547
51PAK21.07187046
52MAPKAPK31.01541315
53MTOR1.01139076
54MARK30.99052182
55BTK0.99002597
56FGFR40.97691892
57PDK20.97572631
58RPS6KA40.97461742
59RIPK40.97146856
60TXK0.96859994
61ARAF0.95917647
62ABL20.89488239
63ICK0.89012006
64ZAP700.87313781
65TESK20.87181674
66ILK0.87079432
67MAP3K70.85803836
68NME20.84236146
69TYK20.81637202
70DYRK30.81608726
71CHEK20.79103124
72JAK30.78588496
73CDK70.76051492
74LATS10.75305130
75DYRK1B0.74545468
76MELK0.74388278
77PIM10.73549604
78TTK0.73075340
79CSNK2A10.71222888
80CAMK1D0.70681282
81KSR20.70426892
82TAOK10.68867216
83RPS6KA50.68218371
84CAMKK10.67531489
85SIK20.67340299
86IRAK30.66901384
87PTK20.66847677
88NME10.66330011
89DDR20.65945995
90BRD40.65377950
91DAPK30.62929786
92TAOK20.62212970
93LCK0.61305462
94FGFR10.60729321
95PLK40.59939153
96BUB10.59859052
97DYRK20.58939766
98CAMKK20.58128993
99HCK0.56614111
100STK30.56389919
101MAP3K30.55648157
102LYN0.55316149
103MAP2K20.55282831
104TESK10.55198979
105PIK3CA0.55064436
106NLK0.54546082
107CHEK10.53370512
108MAPK110.53154146
109IKBKE0.53118057
110PDPK10.52940519
111RET0.51410747
112IKBKB0.51128880
113TEC0.51007573
114CHUK0.50418988
115EPHB20.49853933
116PDGFRB0.49826614
117MKNK10.49411222
118AURKB0.49408093
119PAK10.49151743
120AKT20.48490107
121RPS6KC10.48179887
122RPS6KL10.48179887
123RPS6KA20.47937611
124MAPKAPK20.46607630
125CAMK1G0.46387711
126RPS6KA10.46085815
127RPS6KA60.45889075
128LATS20.45738733
129SYK0.45449898
130PBK0.45260467
131DMPK0.44942519
132CSK0.44811857
133BLK0.44377189
134KIT0.43864734
135STK40.43458724
136CSF1R0.43144401
137PLK10.42575667
138ATR0.42296350
139EIF2AK10.42141009
140FGFR30.41911719
141TBK10.41875673
142JAK20.41778996
143WEE10.41713414
144ITK0.39750988
145PIM20.39729277
146KDR0.39410699
147STK240.38578816
148FES0.38423993
149PRKCQ0.38385675
150MOS0.38006741
151CDK20.37426768
152MET0.37047698
153JAK10.32955184
154TGFBR20.31472114
155MAP3K110.31290905

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.51439751
2Parkinsons disease_Homo sapiens_hsa050123.16497177
3One carbon pool by folate_Homo sapiens_hsa006702.59974069
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35808013
5Huntingtons disease_Homo sapiens_hsa050162.35070164
6DNA replication_Homo sapiens_hsa030302.18182573
7Chronic myeloid leukemia_Homo sapiens_hsa052202.08300470
8Alzheimers disease_Homo sapiens_hsa050102.07062063
9RNA polymerase_Homo sapiens_hsa030202.03079672
10* Ribosome_Homo sapiens_hsa030101.96932323
11Pyrimidine metabolism_Homo sapiens_hsa002401.87372006
12Spliceosome_Homo sapiens_hsa030401.82647286
13Antigen processing and presentation_Homo sapiens_hsa046121.81580304
14Bladder cancer_Homo sapiens_hsa052191.74453846
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72596690
16RNA transport_Homo sapiens_hsa030131.62997142
17Small cell lung cancer_Homo sapiens_hsa052221.61320200
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.51892208
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46358411
20Biosynthesis of amino acids_Homo sapiens_hsa012301.46035195
21Proteasome_Homo sapiens_hsa030501.45115518
22Acute myeloid leukemia_Homo sapiens_hsa052211.44880337
23B cell receptor signaling pathway_Homo sapiens_hsa046621.43402674
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41863328
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.39610162
26Cell cycle_Homo sapiens_hsa041101.37930698
27Cardiac muscle contraction_Homo sapiens_hsa042601.37048371
28Mismatch repair_Homo sapiens_hsa034301.35198937
29Proteoglycans in cancer_Homo sapiens_hsa052051.32062291
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.29428915
31Non-small cell lung cancer_Homo sapiens_hsa052231.26815793
32mRNA surveillance pathway_Homo sapiens_hsa030151.26597662
33Primary immunodeficiency_Homo sapiens_hsa053401.26563121
34MicroRNAs in cancer_Homo sapiens_hsa052061.25595703
35RNA degradation_Homo sapiens_hsa030181.25365989
36Pentose phosphate pathway_Homo sapiens_hsa000301.25133523
37Notch signaling pathway_Homo sapiens_hsa043301.23928588
38Homologous recombination_Homo sapiens_hsa034401.22839702
39HTLV-I infection_Homo sapiens_hsa051661.22448079
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21498819
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21347414
42p53 signaling pathway_Homo sapiens_hsa041151.21211052
43Base excision repair_Homo sapiens_hsa034101.20894155
44Lysine degradation_Homo sapiens_hsa003101.20704959
45Focal adhesion_Homo sapiens_hsa045101.19343388
46Viral carcinogenesis_Homo sapiens_hsa052031.17839347
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17801783
48mTOR signaling pathway_Homo sapiens_hsa041501.16937141
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16792971
50Carbon metabolism_Homo sapiens_hsa012001.15104677
51Thyroid cancer_Homo sapiens_hsa052161.13952096
52ECM-receptor interaction_Homo sapiens_hsa045121.12889429
53Selenocompound metabolism_Homo sapiens_hsa004501.11322242
54Viral myocarditis_Homo sapiens_hsa054161.10854237
55Apoptosis_Homo sapiens_hsa042101.10106319
56Toxoplasmosis_Homo sapiens_hsa051451.10091880
57Pancreatic cancer_Homo sapiens_hsa052121.10082408
58Adherens junction_Homo sapiens_hsa045201.08427434
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07743666
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02263991
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99966529
62Insulin resistance_Homo sapiens_hsa049310.99771634
63HIF-1 signaling pathway_Homo sapiens_hsa040660.99346571
64Colorectal cancer_Homo sapiens_hsa052100.98183238
65VEGF signaling pathway_Homo sapiens_hsa043700.97139134
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.95365444
67Shigellosis_Homo sapiens_hsa051310.95283925
68Leishmaniasis_Homo sapiens_hsa051400.95249312
69Osteoclast differentiation_Homo sapiens_hsa043800.94831273
70Autoimmune thyroid disease_Homo sapiens_hsa053200.93943455
71Hepatitis B_Homo sapiens_hsa051610.93933399
72Amoebiasis_Homo sapiens_hsa051460.93410357
73Allograft rejection_Homo sapiens_hsa053300.93404190
74Endometrial cancer_Homo sapiens_hsa052130.92801215
75Protein export_Homo sapiens_hsa030600.91707662
76Legionellosis_Homo sapiens_hsa051340.91599154
77Herpes simplex infection_Homo sapiens_hsa051680.91496380
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88464478
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82846616
80Fanconi anemia pathway_Homo sapiens_hsa034600.81520867
81Graft-versus-host disease_Homo sapiens_hsa053320.80335882
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80182980
83Platelet activation_Homo sapiens_hsa046110.78427520
84Purine metabolism_Homo sapiens_hsa002300.77975935
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75396903
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75326873
87Hippo signaling pathway_Homo sapiens_hsa043900.74854667
88Prolactin signaling pathway_Homo sapiens_hsa049170.73661043
89Epstein-Barr virus infection_Homo sapiens_hsa051690.72964628
90Sulfur relay system_Homo sapiens_hsa041220.72953217
91Measles_Homo sapiens_hsa051620.72811657
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72435730
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70181856
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69475849
95Basal transcription factors_Homo sapiens_hsa030220.68935031
96Glioma_Homo sapiens_hsa052140.68601927
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.68451488
98Insulin signaling pathway_Homo sapiens_hsa049100.67150974
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.66898636
100Fat digestion and absorption_Homo sapiens_hsa049750.65625160
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65155348
102Nucleotide excision repair_Homo sapiens_hsa034200.64859529
103AMPK signaling pathway_Homo sapiens_hsa041520.64699187
104T cell receptor signaling pathway_Homo sapiens_hsa046600.64685650
105Renal cell carcinoma_Homo sapiens_hsa052110.64657808
106Prostate cancer_Homo sapiens_hsa052150.63770925
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63721051
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62989734
109Pathways in cancer_Homo sapiens_hsa052000.62961513
110Basal cell carcinoma_Homo sapiens_hsa052170.62560341
111Asthma_Homo sapiens_hsa053100.59617047
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58692107
113Glutathione metabolism_Homo sapiens_hsa004800.57432040
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.56882919
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56056203
116Folate biosynthesis_Homo sapiens_hsa007900.55705305
117Influenza A_Homo sapiens_hsa051640.54094661
118N-Glycan biosynthesis_Homo sapiens_hsa005100.54083615
119Hematopoietic cell lineage_Homo sapiens_hsa046400.52412766
120TGF-beta signaling pathway_Homo sapiens_hsa043500.51392582
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.51302240
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49213345
123Estrogen signaling pathway_Homo sapiens_hsa049150.49148486
124Protein digestion and absorption_Homo sapiens_hsa049740.48064064
125Malaria_Homo sapiens_hsa051440.48001415
126Systemic lupus erythematosus_Homo sapiens_hsa053220.47937804
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.47080069
128Arachidonic acid metabolism_Homo sapiens_hsa005900.46133726
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44452831
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.44051171
131Metabolic pathways_Homo sapiens_hsa011000.43391140
132Type I diabetes mellitus_Homo sapiens_hsa049400.37195447
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36401906
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35242818
135Linoleic acid metabolism_Homo sapiens_hsa005910.34617758
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32120841
137Galactose metabolism_Homo sapiens_hsa000520.30287239
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26538288
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26509891
140Sulfur metabolism_Homo sapiens_hsa009200.24257573
141Regulation of autophagy_Homo sapiens_hsa041400.22724694
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18943451
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14750477
144Pyruvate metabolism_Homo sapiens_hsa006200.14722161
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11398366
146Tyrosine metabolism_Homo sapiens_hsa003500.10464815
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10362016
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09673670

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