RPS12P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycoprotein catabolic process (GO:0006516)9.96227501
2rRNA transcription (GO:0009303)8.53219957
3positive regulation of signal transduction by p53 class mediator (GO:1901798)8.25470221
4SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)6.53284120
5induction of positive chemotaxis (GO:0050930)6.51716011
6macroautophagy (GO:0016236)6.39346548
7meiotic chromosome segregation (GO:0045132)6.05593537
8positive regulation of vascular permeability (GO:0043117)5.96330850
9resolution of meiotic recombination intermediates (GO:0000712)5.92492131
10nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)5.73264046
11positive regulation of defense response to virus by host (GO:0002230)5.71527988
12viral transcription (GO:0019083)5.49250856
13chaperone-mediated protein transport (GO:0072321)5.45741899
14myelin assembly (GO:0032288)5.45056070
15cellular response to exogenous dsRNA (GO:0071360)5.40088598
16translational termination (GO:0006415)5.16719287
17DNA deamination (GO:0045006)5.01785861
18erythrocyte maturation (GO:0043249)5.01202749
19UV protection (GO:0009650)4.97401874
20regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)4.92374875
21reciprocal DNA recombination (GO:0035825)4.88011214
22reciprocal meiotic recombination (GO:0007131)4.88011214
23positive regulation of monocyte chemotaxis (GO:0090026)4.73486782
24I-kappaB kinase/NF-kappaB signaling (GO:0007249)4.71403320
25hematopoietic stem cell differentiation (GO:0060218)4.64489388
26spinal cord development (GO:0021510)4.63430056
27cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)4.59896429
28forebrain morphogenesis (GO:0048853)4.46833789
29energy homeostasis (GO:0097009)4.44749822
30astrocyte differentiation (GO:0048708)4.44736538
31hair cell differentiation (GO:0035315)4.41293323
32protein targeting to ER (GO:0045047)4.12923942
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11404559
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09565107
35translational elongation (GO:0006414)4.08766264
36cotranslational protein targeting to membrane (GO:0006613)4.04358480
37ribosomal small subunit biogenesis (GO:0042274)4.03229783
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93359996
39synaptonemal complex assembly (GO:0007130)3.92661462
40viral life cycle (GO:0019058)3.83837850
41cellular protein complex disassembly (GO:0043624)3.83659116
42protein localization to endoplasmic reticulum (GO:0070972)3.78842333
43regulation of lymphocyte migration (GO:2000401)3.78316729
44heart morphogenesis (GO:0003007)3.67343375
45nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)3.63862663
46positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.62201569
47ribosomal small subunit assembly (GO:0000028)3.60558600
48positive regulation of positive chemotaxis (GO:0050927)3.52264375
49negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.51765512
50regulation of synapse maturation (GO:0090128)3.50235104
51male meiosis I (GO:0007141)3.46103176
52synaptonemal complex organization (GO:0070193)3.44351539
53lateral ventricle development (GO:0021670)3.43512790
54regulation of positive chemotaxis (GO:0050926)3.39230136
55maturation of SSU-rRNA (GO:0030490)3.36132527
56lymphocyte chemotaxis (GO:0048247)3.36079871
57myoblast migration (GO:0051451)3.34458267
58pseudouridine synthesis (GO:0001522)3.26458964
59JNK cascade (GO:0007254)3.25038647
60thrombin receptor signaling pathway (GO:0070493)3.24175998
61peroxisome organization (GO:0007031)3.21932001
62translational initiation (GO:0006413)3.21455062
63protein complex disassembly (GO:0043241)3.21408076
64macrophage chemotaxis (GO:0048246)3.20115850
65regulation of monocyte chemotaxis (GO:0090025)3.19536511
66inositol phosphate-mediated signaling (GO:0048016)3.18697214
67regulation of defense response to virus by host (GO:0050691)3.05105243
68retina vasculature morphogenesis in camera-type eye (GO:0061299)3.02974881
69DNA excision (GO:0044349)3.02795144
70nucleotide-excision repair, DNA damage removal (GO:0000718)3.02795144
71establishment of viral latency (GO:0019043)3.02669364
72macromolecular complex disassembly (GO:0032984)3.02376425
73maintenance of protein location in nucleus (GO:0051457)2.99711273
74piRNA metabolic process (GO:0034587)2.96588159
75glomerulus development (GO:0032835)2.96338661
76protein targeting to membrane (GO:0006612)2.87725524
77protein targeting to lysosome (GO:0006622)2.87675194
78establishment of protein localization to vacuole (GO:0072666)2.87675194
79protein targeting to vacuole (GO:0006623)2.87675194
80regulation of glycogen (starch) synthase activity (GO:2000465)2.86891266
81regulation of activation of Janus kinase activity (GO:0010533)2.86385327
82regulation of signal transduction by p53 class mediator (GO:1901796)2.84352003
83cysteine metabolic process (GO:0006534)2.80956735
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80921578
85negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78259944
86transcription from RNA polymerase I promoter (GO:0006360)2.76091077
87alanine transport (GO:0032328)2.74581241
88proline transport (GO:0015824)2.69283168
89embryonic skeletal joint morphogenesis (GO:0060272)2.68988974
90negative regulation of mast cell activation (GO:0033004)2.68916047
91chromosome organization involved in meiosis (GO:0070192)2.68506399
92response to phenylpropanoid (GO:0080184)2.67827384
93transcription elongation from RNA polymerase I promoter (GO:0006362)2.63072962
94metallo-sulfur cluster assembly (GO:0031163)2.62813095
95iron-sulfur cluster assembly (GO:0016226)2.62813095
96IMP biosynthetic process (GO:0006188)2.61207506
97response to UV-B (GO:0010224)2.60686159
98activation of MAPKKK activity (GO:0000185)16.4894980
99leukocyte aggregation (GO:0070486)12.6075375
100positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)10.5361594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.65805852
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.49100419
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.12711880
4EZH2_22144423_ChIP-Seq_EOC_Human3.08103121
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00305365
6STAT1_20625510_ChIP-Seq_HELA_Human2.72042285
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46049036
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44205418
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39770207
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29772594
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.26484394
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.21250512
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17722264
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.04437947
15ELF1_20517297_ChIP-Seq_JURKAT_Human1.94469576
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92068235
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.91444981
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85637784
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.81535596
20TP53_22573176_ChIP-Seq_HFKS_Human1.79685361
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72013834
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71408534
23AR_20517297_ChIP-Seq_VCAP_Human1.71224811
24TP53_16413492_ChIP-PET_HCT116_Human1.57635578
25E2F1_20622854_ChIP-Seq_HELA_Human1.57130055
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56582540
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54486844
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.52762256
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51702277
30SPI1_20517297_ChIP-Seq_HL60_Human1.50984829
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.50151982
32P53_22127205_ChIP-Seq_FIBROBLAST_Human1.49416087
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49223190
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48806079
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46263600
36PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41693535
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.40928002
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40928002
39DROSHA_22980978_ChIP-Seq_HELA_Human1.40176579
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.37150955
41GBX2_23144817_ChIP-Seq_PC3_Human1.34432443
42TAF2_19829295_ChIP-Seq_ESCs_Human1.33406493
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32227246
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31591640
45GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31520325
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28318260
47NCOR_22424771_ChIP-Seq_293T_Human1.28003933
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26860676
49NANOG_20526341_ChIP-Seq_ESCs_Human1.25958412
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.24841761
51FUS_26573619_Chip-Seq_HEK293_Human1.22290626
52SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22226779
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20914650
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20513836
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19027598
56NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18761897
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18758437
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.17881784
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17833333
60CIITA_25753668_ChIP-Seq_RAJI_Human1.14153926
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12806658
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12389235
63GATA6_21074721_ChIP-Seq_CACO-2_Human1.11635363
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11363772
65SOX2_21211035_ChIP-Seq_LN229_Human1.11342110
66VDR_22108803_ChIP-Seq_LS180_Human1.10418016
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10363962
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09756336
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08860733
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08081931
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07908087
72ETS1_21867929_ChIP-Seq_TH2_Mouse1.06767517
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.05822285
74SA1_27219007_Chip-Seq_Bcells_Human1.04981752
75ERG_20517297_ChIP-Seq_VCAP_Human1.04672258
76MYC_19829295_ChIP-Seq_ESCs_Human1.04501346
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.02729280
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01791639
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01464810
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01363443
81NFI_21473784_ChIP-Seq_ESCs_Mouse1.00902374
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00672257
83PHF8_20622853_ChIP-Seq_HELA_Human1.00610061
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00395693
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99194683
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.99179027
87NANOG_19829295_ChIP-Seq_ESCs_Human0.99126582
88SOX2_19829295_ChIP-Seq_ESCs_Human0.99126582
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98444638
90GABP_17652178_ChIP-ChIP_JURKAT_Human0.98202449
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97962926
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97962926
93RBPJ_21746931_ChIP-Seq_IB4_Human0.97207546
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95050800
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94973540
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94768896
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.93913738
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92740543
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.92652764
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.91529699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000750_abnormal_muscle_regeneration5.44201464
2MP0000013_abnormal_adipose_tissue4.30380771
3MP0009384_cardiac_valve_regurgitation3.99056845
4MP0009379_abnormal_foot_pigmentation3.31455520
5MP0002938_white_spotting3.31406452
6MP0002638_abnormal_pupillary_reflex3.22732096
7MP0003786_premature_aging2.92647615
8MP0000858_altered_metastatic_potential2.54980713
9MP0004947_skin_inflammation2.17454955
10MP0002277_abnormal_respiratory_mucosa2.11800366
11MP0000762_abnormal_tongue_morphology2.09692880
12MP0005623_abnormal_meninges_morphology11.8189530
13MP0005671_abnormal_response_to1.95255581
14MP0006292_abnormal_olfactory_placode1.86901303
15MP0003385_abnormal_body_wall1.86108688
16MP0005551_abnormal_eye_electrophysiolog1.83404842
17MP0004147_increased_porphyrin_level1.77089037
18MP0009764_decreased_sensitivity_to1.69130166
19MP0005584_abnormal_enzyme/coenzyme_acti1.60812438
20MP0005410_abnormal_fertilization1.47297197
21MP0006082_CNS_inflammation1.39290578
22MP0002177_abnormal_outer_ear1.36027088
23MP0010307_abnormal_tumor_latency1.35588138
24MP0002269_muscular_atrophy1.32652660
25MP0003787_abnormal_imprinting1.31739638
26MP0003115_abnormal_respiratory_system1.30023667
27MP0004142_abnormal_muscle_tone1.25131049
28MP0003121_genomic_imprinting1.21481756
29MP0002067_abnormal_sensory_capabilities1.20401373
30MP0000343_altered_response_to1.19758658
31MP0001986_abnormal_taste_sensitivity1.19695669
32MP0003122_maternal_imprinting1.18756605
33MP0000003_abnormal_adipose_tissue1.13672372
34MP0008770_decreased_survivor_rate1.13315546
35MP0009046_muscle_twitch1.09878291
36MP0008877_abnormal_DNA_methylation1.09087702
37MP0004087_abnormal_muscle_fiber1.02346690
38MP0002163_abnormal_gland_morphology0.97453373
39MP0008775_abnormal_heart_ventricle0.95634536
40MP0004130_abnormal_muscle_cell0.92054814
41MP0009765_abnormal_xenobiotic_induced0.91775940
42MP0003137_abnormal_impulse_conducting0.90464549
43MP0006276_abnormal_autonomic_nervous0.87972226
44MP0002102_abnormal_ear_morphology0.86981607
45MP0005195_abnormal_posterior_eye0.86532221
46MP0005379_endocrine/exocrine_gland_phen0.83779600
47MP0002160_abnormal_reproductive_system0.83593529
48MP0002272_abnormal_nervous_system0.81311416
49MP0003755_abnormal_palate_morphology0.80484062
50MP0001800_abnormal_humoral_immune0.79786187
51MP0003690_abnormal_glial_cell0.78973423
52MP0005389_reproductive_system_phenotype0.78504803
53MP0001502_abnormal_circadian_rhythm0.78302999
54MP0003279_aneurysm0.76725059
55MP0008872_abnormal_physiological_respon0.74513178
56MP0003221_abnormal_cardiomyocyte_apopto0.74261587
57MP0002132_abnormal_respiratory_system0.73064700
58MP0003698_abnormal_male_reproductive0.70426037
59MP0009785_altered_susceptibility_to0.68683134
60MP0008875_abnormal_xenobiotic_pharmacok0.66789857
61MP0002572_abnormal_emotion/affect_behav0.66227488
62MP0002837_dystrophic_cardiac_calcinosis0.65554449
63MP0008873_increased_physiological_sensi0.61631166
64MP0002106_abnormal_muscle_physiology0.61507252
65MP0008874_decreased_physiological_sensi0.57577110
66MP0002019_abnormal_tumor_incidence0.57278723
67MP0008058_abnormal_DNA_repair0.56424099
68MP0003763_abnormal_thymus_physiology0.55432537
69MP0009745_abnormal_behavioral_response0.55111013
70MP0005645_abnormal_hypothalamus_physiol0.55021954
71MP0000631_abnormal_neuroendocrine_gland0.54955110
72MP0002733_abnormal_thermal_nociception0.54917097
73MP0001905_abnormal_dopamine_level0.54731704
74MP0000749_muscle_degeneration0.53386024
75MP0002752_abnormal_somatic_nervous0.53272257
76MP0003806_abnormal_nucleotide_metabolis0.52098070
77MP0003699_abnormal_female_reproductive0.51544136
78MP0002723_abnormal_immune_serum0.50708828
79MP0002876_abnormal_thyroid_physiology0.50321140
80MP0002933_joint_inflammation0.49805453
81MP0009250_abnormal_appendicular_skeleto0.49690506
82MP0005369_muscle_phenotype0.48885459
83MP0008469_abnormal_protein_level0.48727105
84MP0001929_abnormal_gametogenesis0.48584796
85MP0001145_abnormal_male_reproductive0.48111884
86MP0002882_abnormal_neuron_morphology0.47489801
87MP0002210_abnormal_sex_determination0.46438811
88MP0002452_abnormal_antigen_presenting0.46314365
89MP0005423_abnormal_somatic_nervous0.46027777
90MP0003011_delayed_dark_adaptation0.45797340
91MP0002063_abnormal_learning/memory/cond0.44451491
92MP0003724_increased_susceptibility_to0.43745215
93MP0005164_abnormal_response_to0.43346923
94MP0003186_abnormal_redox_activity0.43297136
95MP0000653_abnormal_sex_gland0.43191719
96MP0003866_abnormal_defecation0.43013970
97MP0002161_abnormal_fertility/fecundity0.42933807
98MP0002653_abnormal_ependyma_morphology0.42179739
99MP0005025_abnormal_response_to0.42033632
100MP0000778_abnormal_nervous_system0.42001364

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)9.24548291
2Hypoplasia of the pons (HP:0012110)8.95040891
3Abnormality of the pons (HP:0007361)8.03484153
4Fatigue (HP:0012378)7.95237792
5Decreased electroretinogram (ERG) amplitude (HP:0000654)7.39633887
6Buphthalmos (HP:0000557)7.14118429
7Difficulty climbing stairs (HP:0003551)7.04542712
8Aplasia/Hypoplasia affecting the retina (HP:0008061)6.71169095
9Abolished electroretinogram (ERG) (HP:0000550)5.58174983
10Entropion (HP:0000621)4.46831419
11Megalocornea (HP:0000485)4.27468306
12Congenital glaucoma (HP:0001087)4.27234594
13Generalized hypotonia (HP:0001290)4.02973738
14Severe muscular hypotonia (HP:0006829)4.00487462
15Lissencephaly (HP:0001339)3.71487666
16Abnormality of DNA repair (HP:0003254)3.69458554
17Poikiloderma (HP:0001029)3.55122321
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.17776892
19Hypoplasia of the brainstem (HP:0002365)3.17611081
20Aplasia/Hypoplasia of the brainstem (HP:0007362)3.17611081
21Meningocele (HP:0002435)3.09701147
22Intellectual disability, profound (HP:0002187)3.08486212
23Generalized muscle weakness (HP:0003324)3.02030225
24Abnormality of the vitreous humor (HP:0004327)2.99450167
25Pallor (HP:0000980)2.94707187
26Gowers sign (HP:0003391)2.93964739
27Abnormality of vision evoked potentials (HP:0000649)2.91708165
28Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.83288314
29IgG deficiency (HP:0004315)2.78919881
30Non-midline cleft lip (HP:0100335)2.75440038
31Fragile nails (HP:0001808)2.71764408
32Pachygyria (HP:0001302)2.70648086
33Increased IgM level (HP:0003496)2.62301847
34Severe global developmental delay (HP:0011344)2.59888341
35Decreased subcutaneous fat (HP:0001002)2.54907013
36Mesangial abnormality (HP:0001966)2.54166439
37Submucous cleft hard palate (HP:0000176)2.49253704
38Muscular dystrophy (HP:0003560)2.48576004
39Supranuclear gaze palsy (HP:0000605)2.46330677
40Erythroderma (HP:0001019)2.40964932
41Papilledema (HP:0001085)2.37007746
42Muscle stiffness (HP:0003552)2.31555012
43Keratitis (HP:0000491)2.19423621
44Cone-rod dystrophy (HP:0000548)2.07446794
45Prominent metopic ridge (HP:0005487)2.00569945
46Eosinophilia (HP:0001880)2.00222880
47Congenital ichthyosiform erythroderma (HP:0007431)2.00108905
48Retinal atrophy (HP:0001105)11.7973233
49Cerebellar dysplasia (HP:0007033)11.7092516
50Type II lissencephaly (HP:0007260)10.4171844
51Brittle hair (HP:0002299)1.91304729
52Abnormality of the metopic suture (HP:0005556)1.82714167
53Slow saccadic eye movements (HP:0000514)1.81656095
54Holoprosencephaly (HP:0001360)1.81348561
55Abnormality of subcutaneous fat tissue (HP:0001001)1.80844522
56Stenosis of the external auditory canal (HP:0000402)1.80141928
57Rectal prolapse (HP:0002035)1.79284564
58Nephronophthisis (HP:0000090)1.78425867
59Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76354227
60Ectropion (HP:0000656)1.73513282
61Molar tooth sign on MRI (HP:0002419)1.72156732
62Abnormality of midbrain morphology (HP:0002418)1.72156732
63Polymicrogyria (HP:0002126)1.69651591
64Elevated erythrocyte sedimentation rate (HP:0003565)1.64264684
65Sacral dimple (HP:0000960)1.64019032
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63115741
67Dandy-Walker malformation (HP:0001305)1.59723151
68Cerebral hypomyelination (HP:0006808)1.51241510
69Delayed closure of the anterior fontanelle (HP:0001476)1.50618488
70Ileus (HP:0002595)1.49785916
71Retinal detachment (HP:0000541)1.47396624
72Everted lower lip vermilion (HP:0000232)1.45729425
73Medial flaring of the eyebrow (HP:0010747)1.44432300
74Chronic hepatic failure (HP:0100626)1.43197783
75Reticulocytopenia (HP:0001896)1.42446702
76Granulocytopenia (HP:0001913)1.42208007
77Nephropathy (HP:0000112)1.39639305
78Omphalocele (HP:0001539)1.38701599
79Hypoalbuminemia (HP:0003073)1.38387077
80Abnormal albumin level (HP:0012116)1.38387077
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.36209654
82Absent/shortened dynein arms (HP:0200106)1.36209654
83Abnormality of eosinophils (HP:0001879)1.34174837
84Diastasis recti (HP:0001540)1.33855427
85Death in childhood (HP:0003819)1.33221069
86Cellular immunodeficiency (HP:0005374)1.32383284
87Abnormality of cells of the erythroid lineage (HP:0012130)1.31739824
88Abnormality of the renal medulla (HP:0100957)1.30754679
89Intellectual disability, severe (HP:0010864)1.30277058
90Tubular atrophy (HP:0000092)1.29982386
91Decreased muscle mass (HP:0003199)1.29453782
92Colon cancer (HP:0003003)1.29084370
93Conical tooth (HP:0000698)1.28557009
94Myoclonus (HP:0001336)1.28257073
95Asplenia (HP:0001746)1.27392359
96Pancreatic fibrosis (HP:0100732)1.27283323
97Abnormality of incisor morphology (HP:0011063)1.26850869
98Cerebellar hypoplasia (HP:0001321)1.26545746
99Septo-optic dysplasia (HP:0100842)1.25247115
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.24770969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK39.15996926
2STK109.08475337
3PIM13.56621864
4STK113.24930238
5TXK2.89352216
6PTK2B2.73060228
7LMTK22.64556808
8MAP4K12.08778897
9NLK1.86374671
10MAP3K111.66806458
11PRKCH1.65878358
12MAP4K21.54819787
13STK161.46113336
14PIK3CA1.32065396
15EPHA31.08419290
16FRK1.07469118
17PHKG20.99604440
18PHKG10.99604440
19MAP3K130.93906304
20MAP3K120.90067735
21CDK190.85478458
22CLK10.85101873
23DYRK20.83614865
24MAP2K20.81568077
25ADRBK20.80925893
26EPHB20.71304762
27GSK3A0.68696432
28GRK10.68177841
29TAOK30.66323387
30WNK40.63262379
31IKBKB0.61930342
32IRAK10.60125849
33TYRO30.59855534
34CSNK1G30.58452009
35MAPK150.52940723
36PRKCE0.51074929
37CSNK1A1L0.50120324
38PRKCQ0.47252129
39LCK0.46682291
40AKT20.46438608
41CSNK1G20.46360599
42INSRR0.46102600
43PRKCG0.45885292
44WNK30.45720864
45MELK0.44474128
46TLK10.44000130
47WNK10.43200474
48CSNK1G10.42089864
49TIE10.41934039
50OBSCN0.41072386
51PKN10.40883892
52MAPK130.39006469
53TAOK20.38853262
54CDC70.38816820
55SGK30.38671155
56DYRK1A0.38535541
57PRKCI0.37143054
58MAPK70.36694308
59GRK70.36474718
60ZAP700.36261306
61CAMKK20.35491192
62HIPK20.35027973
63MAP2K70.34177442
64MAP2K40.33812747
65CSNK1D0.33719714
66RPS6KA50.32886606
67FYN0.32313432
68CSNK1A10.31928074
69RPS6KA60.29737878
70BLK0.29412242
71ERBB20.28542699
72PRKCD0.28524744
73YES10.28443696
74LYN0.26744687
75PRKACA0.26332848
76MAP3K40.26146613
77BRSK20.25521348
78PRKG20.25309988
79CSNK2A20.24295632
80MUSK0.24077191
81SGK10.21847664
82IGF1R0.21763003
83NTRK20.21715333
84MAPK140.21649580
85CAMK2A0.21390307
86CSNK1E0.21300027
87RPS6KB20.19738634
88TEC0.19252770
89PIK3CG0.19209057
90CAMK10.18466184
91CSK0.17496457
92EGFR0.17421342
93RPS6KA30.17056237
94PRKACG0.16979883
95KDR0.16516901
96ROCK10.16390939
97PRKCA0.16024022
98RPS6KC10.15743579
99RPS6KL10.15743579
100FGFR40.15659985

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005145.60102775
2Ribosome_Homo sapiens_hsa030104.76353769
3SNARE interactions in vesicular transport_Homo sapiens_hsa041304.09789439
4NOD-like receptor signaling pathway_Homo sapiens_hsa046213.84581421
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.83631316
6Sulfur relay system_Homo sapiens_hsa041222.68406308
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42679101
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31701497
9Oxidative phosphorylation_Homo sapiens_hsa001902.28277667
10Basal transcription factors_Homo sapiens_hsa030222.28108449
11Graft-versus-host disease_Homo sapiens_hsa053322.15261695
12Leishmaniasis_Homo sapiens_hsa051401.91870036
13Parkinsons disease_Homo sapiens_hsa050121.79251879
14Cardiac muscle contraction_Homo sapiens_hsa042601.70086130
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68149621
16TNF signaling pathway_Homo sapiens_hsa046681.62642472
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56435952
18Huntingtons disease_Homo sapiens_hsa050161.50583205
19Toxoplasmosis_Homo sapiens_hsa051451.45082861
20Sulfur metabolism_Homo sapiens_hsa009201.42445807
21Allograft rejection_Homo sapiens_hsa053301.42406366
22Autoimmune thyroid disease_Homo sapiens_hsa053201.42045152
23Asthma_Homo sapiens_hsa053101.38919952
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37673746
25Alzheimers disease_Homo sapiens_hsa050101.34356857
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28254874
27Insulin secretion_Homo sapiens_hsa049111.27344428
28Nucleotide excision repair_Homo sapiens_hsa034201.27166492
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.18614759
30Mineral absorption_Homo sapiens_hsa049781.18122953
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.15617745
32Regulation of autophagy_Homo sapiens_hsa041401.10866082
33Type I diabetes mellitus_Homo sapiens_hsa049401.07233450
34Linoleic acid metabolism_Homo sapiens_hsa005911.06964157
35RNA polymerase_Homo sapiens_hsa030201.04641454
36Osteoclast differentiation_Homo sapiens_hsa043801.00663223
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96945650
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95143994
39Glycosaminoglycan degradation_Homo sapiens_hsa005310.90286644
40Primary immunodeficiency_Homo sapiens_hsa053400.87704370
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86354954
42Homologous recombination_Homo sapiens_hsa034400.80759963
43Rheumatoid arthritis_Homo sapiens_hsa053230.78719180
44Cocaine addiction_Homo sapiens_hsa050300.73664999
45Herpes simplex infection_Homo sapiens_hsa051680.70871789
46Antigen processing and presentation_Homo sapiens_hsa046120.67716409
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67278704
48Phagosome_Homo sapiens_hsa041450.66977483
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.62605154
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61529029
51Thyroid hormone synthesis_Homo sapiens_hsa049180.60417178
52Bile secretion_Homo sapiens_hsa049760.58781378
53MAPK signaling pathway_Homo sapiens_hsa040100.58096021
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56124974
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54665604
56Nicotine addiction_Homo sapiens_hsa050330.54543674
57Olfactory transduction_Homo sapiens_hsa047400.53693566
58Staphylococcus aureus infection_Homo sapiens_hsa051500.50965972
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50964778
60Retinol metabolism_Homo sapiens_hsa008300.48195143
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48129922
62Chemical carcinogenesis_Homo sapiens_hsa052040.47309451
63Peroxisome_Homo sapiens_hsa041460.46520108
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.46445459
65Fat digestion and absorption_Homo sapiens_hsa049750.45920419
66Caffeine metabolism_Homo sapiens_hsa002320.44462492
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44056317
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43737229
69Dopaminergic synapse_Homo sapiens_hsa047280.43143158
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42884666
71Ether lipid metabolism_Homo sapiens_hsa005650.42726011
72Pentose phosphate pathway_Homo sapiens_hsa000300.41085686
73cAMP signaling pathway_Homo sapiens_hsa040240.38833116
74Epstein-Barr virus infection_Homo sapiens_hsa051690.38562738
75Viral myocarditis_Homo sapiens_hsa054160.35758267
76Fatty acid degradation_Homo sapiens_hsa000710.35210226
77Glucagon signaling pathway_Homo sapiens_hsa049220.34835957
78Pancreatic secretion_Homo sapiens_hsa049720.34775285
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34534688
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34206484
81Proteasome_Homo sapiens_hsa030500.33559993
82Gastric acid secretion_Homo sapiens_hsa049710.33548409
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33304310
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.32739728
85PPAR signaling pathway_Homo sapiens_hsa033200.32203441
86Collecting duct acid secretion_Homo sapiens_hsa049660.31423980
87Protein digestion and absorption_Homo sapiens_hsa049740.31175481
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30971696
89RNA degradation_Homo sapiens_hsa030180.30856537
90Fanconi anemia pathway_Homo sapiens_hsa034600.30360008
91Amphetamine addiction_Homo sapiens_hsa050310.29924780
92Ovarian steroidogenesis_Homo sapiens_hsa049130.29716987
93Ras signaling pathway_Homo sapiens_hsa040140.29190068
94Salivary secretion_Homo sapiens_hsa049700.27451199
95Chemokine signaling pathway_Homo sapiens_hsa040620.27380814
96Butanoate metabolism_Homo sapiens_hsa006500.27280316
97Tryptophan metabolism_Homo sapiens_hsa003800.26729522
98Nitrogen metabolism_Homo sapiens_hsa009100.26523439
99Phototransduction_Homo sapiens_hsa047440.24219629
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23569800

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