RPS12P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of prostaglandin secretion (GO:0032308)9.90742417
2regulation of prostaglandin secretion (GO:0032306)8.44684417
3regulation of corticosteroid hormone secretion (GO:2000846)8.43342886
4viral transcription (GO:0019083)7.92515757
5behavioral response to nicotine (GO:0035095)7.64601364
6translational termination (GO:0006415)7.46191097
7positive regulation of icosanoid secretion (GO:0032305)7.30787473
8positive regulation of fatty acid transport (GO:2000193)6.87015914
9translational elongation (GO:0006414)6.37915838
10ribosomal small subunit assembly (GO:0000028)6.34035072
11regulation of appetite (GO:0032098)6.31087893
12regulation of steroid hormone secretion (GO:2000831)6.16730049
13negative regulation of cholesterol transport (GO:0032375)6.12245131
14negative regulation of sterol transport (GO:0032372)6.12245131
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89851851
16viral life cycle (GO:0019058)5.88245287
17phosphatidylserine acyl-chain remodeling (GO:0036150)5.80196602
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.80110749
19ribosomal small subunit biogenesis (GO:0042274)5.79467066
20cotranslational protein targeting to membrane (GO:0006613)5.76959478
21protein targeting to ER (GO:0045047)5.74464842
22locomotory exploration behavior (GO:0035641)5.68947130
23phosphatidylinositol acyl-chain remodeling (GO:0036149)5.64011852
24cellular protein complex disassembly (GO:0043624)5.62136436
25phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.56100965
26regulation of icosanoid secretion (GO:0032303)5.50940884
27establishment of protein localization to endoplasmic reticulum (GO:0072599)5.50885700
28protein localization to endoplasmic reticulum (GO:0070972)5.38260337
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.34062134
30positive regulation of macrophage derived foam cell differentiation (GO:0010744)4.97734876
31protein complex disassembly (GO:0043241)4.76336964
32protein neddylation (GO:0045116)4.73113030
33anterograde synaptic vesicle transport (GO:0048490)4.62595224
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46742080
35translational initiation (GO:0006413)4.44534786
36inner ear receptor cell development (GO:0060119)4.43957190
37macromolecular complex disassembly (GO:0032984)4.39971590
38phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.37721262
39ATP synthesis coupled proton transport (GO:0015986)4.26228183
40energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26228183
41exploration behavior (GO:0035640)4.19948814
42regulation of cholesterol efflux (GO:0010874)4.14139358
43positive regulation of organic acid transport (GO:0032892)4.06157897
44synaptic transmission, cholinergic (GO:0007271)3.97570586
45phosphatidylcholine acyl-chain remodeling (GO:0036151)3.88768630
46protein targeting to membrane (GO:0006612)3.76589280
47positive regulation of protein sumoylation (GO:0033235)3.75598938
48maturation of SSU-rRNA (GO:0030490)3.59245802
49positive regulation of vascular permeability (GO:0043117)3.56011305
50negative regulation of astrocyte differentiation (GO:0048712)3.44276936
51positive regulation of lipid storage (GO:0010884)3.42946331
52detection of mechanical stimulus involved in sensory perception (GO:0050974)3.40182568
53reflex (GO:0060004)3.39314964
54melanosome organization (GO:0032438)3.38291018
55ribosomal large subunit biogenesis (GO:0042273)3.37919759
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.30478117
57anterograde axon cargo transport (GO:0008089)3.27339354
58regulation of endocrine process (GO:0044060)3.25537271
59nonmotile primary cilium assembly (GO:0035058)3.24547931
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.23140229
61pigmentation (GO:0043473)3.20845217
62regulation of fatty acid transport (GO:2000191)3.13626936
63pigment granule organization (GO:0048753)3.13425896
64negative regulation of potassium ion transmembrane transport (GO:1901380)3.11368642
65phosphatidylserine metabolic process (GO:0006658)3.10791768
66mRNA catabolic process (GO:0006402)3.07489400
67peptide hormone processing (GO:0016486)3.02803679
68phosphatidic acid metabolic process (GO:0046473)3.02391620
69phosphatidic acid biosynthetic process (GO:0006654)3.02391620
70cysteine metabolic process (GO:0006534)2.98389000
71positive regulation of receptor biosynthetic process (GO:0010870)2.95619925
72regulation of macrophage activation (GO:0043030)2.90985493
73metallo-sulfur cluster assembly (GO:0031163)2.83721146
74iron-sulfur cluster assembly (GO:0016226)2.83721146
75auditory receptor cell differentiation (GO:0042491)2.83696670
76primary amino compound metabolic process (GO:1901160)2.80843753
77cell proliferation in forebrain (GO:0021846)2.77237518
78regulation of microtubule-based movement (GO:0060632)2.75355982
79apoptotic DNA fragmentation (GO:0006309)2.75161570
80regulation of macrophage derived foam cell differentiation (GO:0010743)2.71284071
81translation (GO:0006412)2.67624613
82RNA catabolic process (GO:0006401)2.65573435
83positive regulation of hair follicle development (GO:0051798)2.64046945
84positive regulation of hair cycle (GO:0042635)2.64046945
85phosphatidylglycerol metabolic process (GO:0046471)2.59422550
86signal complex assembly (GO:0007172)2.59326987
87lens fiber cell differentiation (GO:0070306)2.56859978
88establishment of protein localization to membrane (GO:0090150)2.55273148
89ncRNA 3-end processing (GO:0043628)2.54657573
90middle ear morphogenesis (GO:0042474)2.54116818
91positive regulation of dendritic spine morphogenesis (GO:0061003)2.53728893
92water-soluble vitamin biosynthetic process (GO:0042364)2.51410120
93negative regulation of lipid transport (GO:0032369)2.51362532
94positive regulation of cell fate commitment (GO:0010455)2.50984973
95positive regulation of growth hormone secretion (GO:0060124)2.48656018
96regulation of ruffle assembly (GO:1900027)2.47427838
97pyrimidine dimer repair (GO:0006290)2.47164955
98alditol phosphate metabolic process (GO:0052646)2.43822715
99ribonucleoprotein complex biogenesis (GO:0022613)2.42045708
100regulation of glucocorticoid secretion (GO:2000849)10.2479250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.02278662
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.78484514
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.94977758
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.85293688
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78023070
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51737343
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.51038332
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.47511219
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.39216795
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34256815
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32929800
12STAT1_20625510_ChIP-Seq_HELA_Human2.18244436
13REST_21632747_ChIP-Seq_MESCs_Mouse2.13912046
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12392984
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07893848
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02087262
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02087262
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99631870
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84680681
20ZNF274_21170338_ChIP-Seq_K562_Hela1.81304559
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79312614
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78511021
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.77762104
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74951629
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70293848
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68971396
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61813437
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58528209
29TP53_20018659_ChIP-ChIP_R1E_Mouse1.55305865
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53955831
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52492851
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50652899
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.46674500
34NCOR_22424771_ChIP-Seq_293T_Human1.46283258
35RNF2_27304074_Chip-Seq_NSC_Mouse1.45823262
36IGF1R_20145208_ChIP-Seq_DFB_Human1.45625503
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45378500
38TP53_22573176_ChIP-Seq_HFKS_Human1.44905855
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43680025
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42606053
41DROSHA_22980978_ChIP-Seq_HELA_Human1.41708481
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40753059
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.37836854
44TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36781785
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35873146
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34060032
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31439942
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29351286
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.27466384
50VDR_22108803_ChIP-Seq_LS180_Human1.26158974
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.25464084
52HTT_18923047_ChIP-ChIP_STHdh_Human1.25346752
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22778485
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20691066
55NANOG_20526341_ChIP-Seq_ESCs_Human1.20097381
56NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.18243796
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18015831
58GBX2_23144817_ChIP-Seq_PC3_Human1.16839194
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16019558
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15704225
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.12360399
62CTCF_27219007_Chip-Seq_Bcells_Human1.09237167
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07968310
64ER_23166858_ChIP-Seq_MCF-7_Human1.07680087
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.06939377
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06492353
67CTCF_20526341_ChIP-Seq_ESCs_Human1.06148196
68OCT4_20526341_ChIP-Seq_ESCs_Human1.04627663
69OCT4_19829295_ChIP-Seq_ESCs_Human1.01415794
70TAF2_19829295_ChIP-Seq_ESCs_Human1.00887636
71MYC_19829295_ChIP-Seq_ESCs_Human1.00874847
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00562768
73AR_25329375_ChIP-Seq_VCAP_Human1.00116979
74FUS_26573619_Chip-Seq_HEK293_Human0.99714069
75GABP_17652178_ChIP-ChIP_JURKAT_Human0.98827674
76SMAD4_21741376_ChIP-Seq_EPCs_Human0.98417423
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97390968
78FLI1_21867929_ChIP-Seq_CD8_Mouse0.97104183
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.96676118
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96676118
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94434848
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94434848
83KLF4_19829295_ChIP-Seq_ESCs_Human0.92048885
84RXR_22108803_ChIP-Seq_LS180_Human0.91859436
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.91466345
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.90530204
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90320172
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90268836
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.89027694
90SOX2_19829295_ChIP-Seq_ESCs_Human0.88752027
91NANOG_19829295_ChIP-Seq_ESCs_Human0.88752027
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.88726751
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.87952554
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87214043
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85699964
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85424007
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.85347332
98SMAD4_21799915_ChIP-Seq_A2780_Human0.84713669
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83292097
100TP53_16413492_ChIP-PET_HCT116_Human0.82335499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.93888424
2MP0009379_abnormal_foot_pigmentation4.22772295
3MP0001968_abnormal_touch/_nociception4.04275304
4MP0002909_abnormal_adrenal_gland3.90803843
5MP0006292_abnormal_olfactory_placode3.30326531
6MP0005083_abnormal_biliary_tract2.66120446
7MP0001905_abnormal_dopamine_level2.54826588
8MP0002638_abnormal_pupillary_reflex2.47352202
9MP0003879_abnormal_hair_cell2.46378541
10MP0008789_abnormal_olfactory_epithelium2.22036813
11MP0000343_altered_response_to2.14847002
12MP0010386_abnormal_urinary_bladder2.06634584
13MP0003787_abnormal_imprinting2.03763258
14MP0002163_abnormal_gland_morphology1.93011998
15MP0001440_abnormal_grooming_behavior1.85413565
16MP0005409_darkened_coat_color1.83402181
17MP0000537_abnormal_urethra_morphology1.82317153
18MP0005394_taste/olfaction_phenotype1.80507661
19MP0005499_abnormal_olfactory_system1.80507661
20MP0002160_abnormal_reproductive_system1.75900660
21MP0003122_maternal_imprinting1.74377165
22MP0002938_white_spotting1.59153121
23MP0009745_abnormal_behavioral_response1.58996581
24MP0009840_abnormal_foam_cell1.55960389
25MP0000639_abnormal_adrenal_gland1.49444936
26MP0005645_abnormal_hypothalamus_physiol1.48764727
27MP0005646_abnormal_pituitary_gland1.45178720
28MP0008877_abnormal_DNA_methylation1.44394368
29MP0003638_abnormal_response/metabolism_1.43037957
30MP0003123_paternal_imprinting1.40778897
31MP0000026_abnormal_inner_ear1.38952076
32MP0003279_aneurysm1.38647674
33MP0002557_abnormal_social/conspecific_i1.37235579
34MP0003011_delayed_dark_adaptation1.30683440
35MP0000371_diluted_coat_color1.30471716
36MP0004484_altered_response_of1.29890701
37MP0000566_synostosis1.27315209
38MP0001485_abnormal_pinna_reflex1.26319289
39MP0005386_behavior/neurological_phenoty1.26287234
40MP0004924_abnormal_behavior1.26287234
41MP0005448_abnormal_energy_balance1.25723224
42MP0003121_genomic_imprinting1.23885392
43MP0004742_abnormal_vestibular_system1.23323411
44MP0009333_abnormal_splenocyte_physiolog1.23105675
45MP0001963_abnormal_hearing_physiology1.22294903
46MP0004142_abnormal_muscle_tone1.22032837
47MP0005389_reproductive_system_phenotype1.21512534
48MP0005085_abnormal_gallbladder_physiolo1.15543444
49MP0000049_abnormal_middle_ear1.15483632
50MP0004885_abnormal_endolymph1.14483624
51MP0003880_abnormal_central_pattern1.14145234
52MP0002572_abnormal_emotion/affect_behav1.12381513
53MP0000230_abnormal_systemic_arterial1.10346829
54MP0000538_abnormal_urinary_bladder1.10082555
55MP0002063_abnormal_learning/memory/cond1.09261434
56MP0002837_dystrophic_cardiac_calcinosis1.09035838
57MP0002184_abnormal_innervation1.06215030
58MP0009053_abnormal_anal_canal1.04409786
59MP0006276_abnormal_autonomic_nervous1.03771434
60MP0006072_abnormal_retinal_apoptosis1.03609472
61MP0000778_abnormal_nervous_system1.02453704
62MP0002277_abnormal_respiratory_mucosa1.02424550
63MP0002735_abnormal_chemical_nociception0.99505760
64MP0003938_abnormal_ear_development0.99347842
65MP0009384_cardiac_valve_regurgitation0.98356501
66MP0009115_abnormal_fat_cell0.94937025
67MP0003283_abnormal_digestive_organ0.94197152
68MP0002067_abnormal_sensory_capabilities0.93770379
69MP0002272_abnormal_nervous_system0.89182590
70MP0006054_spinal_hemorrhage0.86783219
71MP0000569_abnormal_digit_pigmentation0.86374960
72MP0010030_abnormal_orbit_morphology0.85993028
73MP0003635_abnormal_synaptic_transmissio0.85334318
74MP0005379_endocrine/exocrine_gland_phen0.84957297
75MP0002064_seizures0.84859023
76MP0005671_abnormal_response_to0.83899618
77MP0001502_abnormal_circadian_rhythm0.83186130
78MP0002876_abnormal_thyroid_physiology0.79962238
79MP0003315_abnormal_perineum_morphology0.79827029
80MP0005551_abnormal_eye_electrophysiolog0.79755860
81MP0002075_abnormal_coat/hair_pigmentati0.79682314
82MP0002249_abnormal_larynx_morphology0.79475612
83MP0001765_abnormal_ion_homeostasis0.79072077
84MP0002233_abnormal_nose_morphology0.78728955
85MP0001970_abnormal_pain_threshold0.78611452
86MP0002095_abnormal_skin_pigmentation0.77943274
87MP0000465_gastrointestinal_hemorrhage0.77362072
88MP0008775_abnormal_heart_ventricle0.76432746
89MP0002733_abnormal_thermal_nociception0.74710375
90MP0004145_abnormal_muscle_electrophysio0.74646437
91MP0003646_muscle_fatigue0.73352627
92MP0002752_abnormal_somatic_nervous0.71735050
93MP0001986_abnormal_taste_sensitivity0.70871216
94MP0002653_abnormal_ependyma_morphology0.70761765
95MP0000631_abnormal_neuroendocrine_gland0.70671936
96MP0003698_abnormal_male_reproductive0.66934908
97MP0001486_abnormal_startle_reflex0.65382025
98MP0009780_abnormal_chondrocyte_physiolo0.64888087
99MP0000428_abnormal_craniofacial_morphol0.63778203
100MP0005623_abnormal_meninges_morphology0.63525138

Predicted human phenotypes

RankGene SetZ-score
1Symptomatic seizures (HP:0011145)8.30080606
2Abnormality of cells of the erythroid lineage (HP:0012130)4.21362374
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.83364199
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.83364199
5Reduced antithrombin III activity (HP:0001976)3.62167041
6Facial hemangioma (HP:0000329)3.58538793
7Hyperlipoproteinemia (HP:0010980)3.57928662
8Macrocytic anemia (HP:0001972)3.41419088
9Abnormal number of erythroid precursors (HP:0012131)3.40391895
10Reticulocytopenia (HP:0001896)3.27171494
11Pallor (HP:0000980)3.09099774
12Short chin (HP:0000331)3.05444986
13Stenosis of the external auditory canal (HP:0000402)3.03667678
14Hyperthyroidism (HP:0000836)2.96130549
15Abnormal protein glycosylation (HP:0012346)2.92607643
16Abnormal glycosylation (HP:0012345)2.92607643
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92607643
18Abnormal protein N-linked glycosylation (HP:0012347)2.92607643
19Hypochromic microcytic anemia (HP:0004840)2.91345149
20Bony spicule pigmentary retinopathy (HP:0007737)2.87330003
21Abnormal rod and cone electroretinograms (HP:0008323)2.78749373
22Abnormality of DNA repair (HP:0003254)2.69757673
23Protruding tongue (HP:0010808)2.67923850
24Septo-optic dysplasia (HP:0100842)2.67907886
25Abnormality of the columella (HP:0009929)2.67533120
26Thoracolumbar scoliosis (HP:0002944)2.67524653
27Partial duplication of thumb phalanx (HP:0009944)2.67225287
28Asplenia (HP:0001746)2.63542471
29Xanthomatosis (HP:0000991)2.61463948
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.55154198
31Polydipsia (HP:0001959)2.51033429
32Abnormal drinking behavior (HP:0030082)2.51033429
33Poikiloderma (HP:0001029)2.50796626
34Decreased circulating renin level (HP:0003351)2.44629292
35Partial duplication of the phalanx of hand (HP:0009999)2.37151491
36Rib fusion (HP:0000902)2.34831580
37Pendular nystagmus (HP:0012043)2.27428279
38Abnormality of the labia minora (HP:0012880)2.26291608
39Colon cancer (HP:0003003)2.25940607
40Hypoplasia of the radius (HP:0002984)2.23182163
41Medial flaring of the eyebrow (HP:0010747)2.18367120
42Myokymia (HP:0002411)2.17396119
43Limb dystonia (HP:0002451)2.16369414
44Vitreoretinal degeneration (HP:0000655)2.14479801
45Abolished electroretinogram (ERG) (HP:0000550)2.12855983
46Syncope (HP:0001279)2.11003363
47Protuberant abdomen (HP:0001538)2.10468668
48Hypoplasia of the ulna (HP:0003022)2.09051463
49Humeroradial synostosis (HP:0003041)2.06717550
50Synostosis involving the elbow (HP:0003938)2.06717550
51Abnormality of the middle phalanges of the toes (HP:0010183)2.04452708
52Gait imbalance (HP:0002141)2.02960833
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02418706
54Prolonged QT interval (HP:0001657)2.00646957
55Hypoglycemic seizures (HP:0002173)11.8527199
56Hyperglycinemia (HP:0002154)1.98610397
57Absent thumb (HP:0009777)1.97740490
58Aplasia/Hypoplasia of the ulna (HP:0006495)1.91786044
59Polyuria (HP:0000103)1.91016435
60Sleep apnea (HP:0010535)1.91013145
61Adrenal hypoplasia (HP:0000835)1.89587182
62Abnormality of the renal cortex (HP:0011035)1.89148167
63Abnormality of renal excretion (HP:0011036)1.84446534
64Abnormality of the nasal septum (HP:0000419)1.84016187
65Esophageal atresia (HP:0002032)1.82802081
66Congenital sensorineural hearing impairment (HP:0008527)1.81037454
67Maternal diabetes (HP:0009800)1.81028161
68Depressed nasal ridge (HP:0000457)1.80965359
69Acute necrotizing encephalopathy (HP:0006965)1.80580557
70Pancreatic fibrosis (HP:0100732)1.80574991
71Congenital primary aphakia (HP:0007707)1.79594899
72Fused cervical vertebrae (HP:0002949)1.77781626
73Absent septum pellucidum (HP:0001331)1.75920859
74Enlarged kidneys (HP:0000105)1.75655962
75Abnormal hemoglobin (HP:0011902)1.74725572
76Vaginal atresia (HP:0000148)1.73743266
77Forearm undergrowth (HP:0009821)1.73680851
78Symphalangism affecting the phalanges of the hand (HP:0009773)1.72700889
79Thoracic kyphosis (HP:0002942)1.71720841
80Tubular atrophy (HP:0000092)1.70481327
81Generalized hypotonia (HP:0001290)1.69610481
82Genital tract atresia (HP:0001827)1.66695088
83Hepatocellular necrosis (HP:0001404)1.65637942
84Capillary hemangiomas (HP:0005306)1.65264884
85Pancreatic cysts (HP:0001737)1.65063895
86Hypothermia (HP:0002045)1.64691259
87Abnormality of midbrain morphology (HP:0002418)1.62890325
88Molar tooth sign on MRI (HP:0002419)1.62890325
89Chorioretinal atrophy (HP:0000533)1.59976231
90Entropion (HP:0000621)1.59307726
91Abnormality of the renal medulla (HP:0100957)1.58812986
92Abnormal urine output (HP:0012590)1.58605830
93Generalized aminoaciduria (HP:0002909)1.58495951
94Duplication of thumb phalanx (HP:0009942)1.58388969
95Hyperaldosteronism (HP:0000859)1.57145400
96Agitation (HP:0000713)1.56757443
97Truncus arteriosus (HP:0001660)1.56305190
98Male pseudohermaphroditism (HP:0000037)1.55838226
99Abnormality of the aortic arch (HP:0012303)1.55477727
100Hyperphosphatemia (HP:0002905)1.55318155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.71235573
2WNK44.73299776
3ADRBK24.61482332
4STK394.19171512
5PRKD23.87207592
6NTRK33.49614739
7ABL22.75936616
8WNK12.22335660
9ERBB22.10769921
10WNK32.09462966
11EPHA42.07379937
12GRK11.68911016
13CLK11.61646658
14ADRBK11.50603758
15TXK1.50380956
16FGFR21.47573186
17MAP2K71.41071198
18DYRK31.38463396
19DYRK1A1.37424638
20MAPK131.35293196
21NEK11.33835731
22EPHB21.26690097
23STK161.17586416
24LRRK21.16052275
25PRKCG1.14433264
26TEC1.13512806
27PINK11.13483845
28OXSR11.12870418
29ZAK1.07948253
30DYRK21.06219398
31CDK191.05125007
32PIK3CA1.00822265
33MAPK150.99848491
34MAP3K40.98758417
35MARK10.95972395
36RPS6KA50.94685643
37SGK30.94141183
38ERN10.91252710
39MAP4K20.84579101
40FRK0.81868035
41MINK10.80895797
42INSRR0.75354870
43PLK40.75296787
44PRKACA0.74345341
45CAMKK20.73587502
46PHKG20.72892792
47PHKG10.72892792
48PAK30.72635437
49BMPR1B0.72293862
50MUSK0.72268683
51LYN0.71965814
52CDC42BPA0.69651844
53PRKD10.67690232
54CSNK1E0.66794095
55NTRK20.65179744
56GRK70.63793363
57OBSCN0.63715922
58PTK60.63545862
59AURKB0.62418147
60PRKCD0.58692149
61TIE10.55965108
62CSNK2A20.54512497
63PDPK10.53078178
64MAP4K10.52792734
65CDK80.51885951
66DYRK1B0.50899938
67PASK0.50644345
68NME20.50477643
69CDK11A0.50364633
70CAMKK10.49331169
71AURKA0.48231202
72TYRO30.47344987
73PRKCQ0.46229479
74FYN0.46165438
75CAMK10.45674007
76NEK20.43760844
77PRKCZ0.43516696
78ABL10.42755438
79CSNK2A10.40762157
80SGK10.40668744
81PRKCA0.39167219
82MAP3K110.36711192
83HCK0.35997806
84MAP2K40.35617989
85PDK20.34973070
86PTK2B0.34527239
87CAMK2A0.34526404
88DAPK30.34044015
89CDK150.32912293
90PRKG10.32711560
91PRKD30.32533893
92CDK50.32461501
93KDR0.32281830
94PRKCH0.32262621
95CASK0.31743316
96PKN10.30564785
97PAK10.29180051
98CSNK1A10.28951811
99RPS6KA30.28793087
100CDK140.28466708

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.16025078
2Sulfur relay system_Homo sapiens_hsa041225.46593277
3Linoleic acid metabolism_Homo sapiens_hsa005914.46754297
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.40647189
5Fat digestion and absorption_Homo sapiens_hsa049753.18800273
6Oxidative phosphorylation_Homo sapiens_hsa001902.44477148
7Ether lipid metabolism_Homo sapiens_hsa005652.38362765
8Arachidonic acid metabolism_Homo sapiens_hsa005902.17038846
9Cardiac muscle contraction_Homo sapiens_hsa042601.96075644
10Parkinsons disease_Homo sapiens_hsa050121.88701095
11Butanoate metabolism_Homo sapiens_hsa006501.72476824
12Nicotine addiction_Homo sapiens_hsa050331.60865093
13Alzheimers disease_Homo sapiens_hsa050101.59085105
14Mismatch repair_Homo sapiens_hsa034301.56982359
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53997961
16Regulation of autophagy_Homo sapiens_hsa041401.49709283
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.34479293
18Olfactory transduction_Homo sapiens_hsa047401.33437415
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28237971
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.26627529
21Huntingtons disease_Homo sapiens_hsa050161.20758712
22Pancreatic secretion_Homo sapiens_hsa049721.17427043
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15908368
24Morphine addiction_Homo sapiens_hsa050321.13620614
25Phototransduction_Homo sapiens_hsa047441.09824322
26Nucleotide excision repair_Homo sapiens_hsa034201.03797544
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03220369
28Nitrogen metabolism_Homo sapiens_hsa009101.02977363
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99149513
30Vascular smooth muscle contraction_Homo sapiens_hsa042700.93187305
31Notch signaling pathway_Homo sapiens_hsa043300.89321454
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.88541685
33DNA replication_Homo sapiens_hsa030300.88069915
34Circadian entrainment_Homo sapiens_hsa047130.87562079
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87458783
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86622244
37Chemical carcinogenesis_Homo sapiens_hsa052040.86596596
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.85247300
39Melanogenesis_Homo sapiens_hsa049160.85203964
40Retinol metabolism_Homo sapiens_hsa008300.83367440
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82823152
42Axon guidance_Homo sapiens_hsa043600.81949959
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.81307116
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80894834
45Insulin secretion_Homo sapiens_hsa049110.79702022
46Homologous recombination_Homo sapiens_hsa034400.77569019
47African trypanosomiasis_Homo sapiens_hsa051430.75923911
48Caffeine metabolism_Homo sapiens_hsa002320.75208721
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75011528
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71166081
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70670526
52Serotonergic synapse_Homo sapiens_hsa047260.67483283
53Ras signaling pathway_Homo sapiens_hsa040140.67456705
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65386832
55Fanconi anemia pathway_Homo sapiens_hsa034600.64594626
56Glutamatergic synapse_Homo sapiens_hsa047240.63285992
57Dopaminergic synapse_Homo sapiens_hsa047280.55963982
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53641117
59Calcium signaling pathway_Homo sapiens_hsa040200.52861401
60Amphetamine addiction_Homo sapiens_hsa050310.52835217
61Taste transduction_Homo sapiens_hsa047420.52403655
62Arginine and proline metabolism_Homo sapiens_hsa003300.52164461
63Cholinergic synapse_Homo sapiens_hsa047250.51926423
64Starch and sucrose metabolism_Homo sapiens_hsa005000.51719171
65Collecting duct acid secretion_Homo sapiens_hsa049660.51198047
66Oxytocin signaling pathway_Homo sapiens_hsa049210.51115906
67Peroxisome_Homo sapiens_hsa041460.48660163
68Salivary secretion_Homo sapiens_hsa049700.48034516
69GABAergic synapse_Homo sapiens_hsa047270.45728400
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42453972
71Hedgehog signaling pathway_Homo sapiens_hsa043400.41848911
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41422657
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40451314
74Metabolic pathways_Homo sapiens_hsa011000.39945296
75Wnt signaling pathway_Homo sapiens_hsa043100.37775428
76Asthma_Homo sapiens_hsa053100.37506716
77Folate biosynthesis_Homo sapiens_hsa007900.35735931
78Basal cell carcinoma_Homo sapiens_hsa052170.31193655
79Ovarian steroidogenesis_Homo sapiens_hsa049130.30563277
80Systemic lupus erythematosus_Homo sapiens_hsa053220.30399082
81Rheumatoid arthritis_Homo sapiens_hsa053230.29926912
82Tryptophan metabolism_Homo sapiens_hsa003800.29515017
83Cocaine addiction_Homo sapiens_hsa050300.28515174
84RNA polymerase_Homo sapiens_hsa030200.28318662
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.27874947
86Rap1 signaling pathway_Homo sapiens_hsa040150.27205910
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26892018
88Purine metabolism_Homo sapiens_hsa002300.26736943
89N-Glycan biosynthesis_Homo sapiens_hsa005100.26199649
90cAMP signaling pathway_Homo sapiens_hsa040240.25422731
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24797540
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24437747
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23880516
94Dorso-ventral axis formation_Homo sapiens_hsa043200.23649008
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23610007
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22482588
97Glutathione metabolism_Homo sapiens_hsa004800.21709256
98Glycerolipid metabolism_Homo sapiens_hsa005610.21274589
99Bile secretion_Homo sapiens_hsa049760.20709699
100ABC transporters_Homo sapiens_hsa020100.19849860

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