ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H4-K12 acetylation (GO:0043983)	9.69280835
2	regulation of posttranscriptional gene silencing (GO:0060147)	8.95886736
3	regulation of gene silencing by miRNA (GO:0060964)	8.95886736
4	regulation of gene silencing by RNA (GO:0060966)	8.95886736
5	fatty acid elongation (GO:0030497)	8.86683328
6	ribosomal small subunit biogenesis (GO:0042274)	8.75648817
7	negative regulation of gene silencing (GO:0060969)	8.72133209
8	ribosomal small subunit assembly (GO:0000028)	6.89901924
9	viral transcription (GO:0019083)	6.73114257
10	myoblast migration (GO:0051451)	6.58078443
11	maturation of SSU-rRNA (GO:0030490)	6.48747543
12	translational termination (GO:0006415)	6.44856120
13	ATP synthesis coupled proton transport (GO:0015986)	5.64536068
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.64536068
15	translational elongation (GO:0006414)	5.58701327
16	heart trabecula morphogenesis (GO:0061384)	5.58545060
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.44361694
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.38723455
19	intra-S DNA damage checkpoint (GO:0031573)	5.30180449
20	cotranslational protein targeting to membrane (GO:0006613)	5.26907945
21	protein targeting to ER (GO:0045047)	5.23207072
22	behavioral response to nicotine (GO:0035095)	5.19588405
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.03623472
24	skeletal muscle tissue regeneration (GO:0043403)	4.99983734
25	membrane tubulation (GO:0097320)	4.99306673
26	protein localization to endoplasmic reticulum (GO:0070972)	4.91279200
27	cellular protein complex disassembly (GO:0043624)	4.90285031
28	viral life cycle (GO:0019058)	4.84924067
29	negative regulation of striated muscle cell apoptotic process (GO:0010664)	4.70983773
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.69833551
31	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	4.69273070
32	autophagic vacuole fusion (GO:0000046)	4.58796307
33	inner cell mass cell proliferation (GO:0001833)	4.53649272
34	regulation of DNA damage checkpoint (GO:2000001)	4.49675401
35	trabecula morphogenesis (GO:0061383)	4.33357545
36	translational initiation (GO:0006413)	4.31392028
37	DNA damage response, detection of DNA damage (GO:0042769)	4.28447657
38	microglial cell activation (GO:0001774)	4.17854056
39	ribonucleoprotein complex biogenesis (GO:0022613)	4.13193461
40	response to pheromone (GO:0019236)	4.09398008
41	male meiosis I (GO:0007141)	4.08734756
42	translation (GO:0006412)	4.06689820
43	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	4.03772435
44	positive regulation of cell cycle G2/M phase transition (GO:1902751)	4.03772435
45	protein complex disassembly (GO:0043241)	4.02154007
46	phagocytosis, engulfment (GO:0006911)	4.00496105
47	chaperone-mediated protein transport (GO:0072321)	3.92446845
48	piRNA metabolic process (GO:0034587)	3.91579961
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.90578784
50	nucleoside diphosphate catabolic process (GO:0009134)	3.89105683
51	macromolecular complex disassembly (GO:0032984)	3.87724881
52	DNA methylation involved in gamete generation (GO:0043046)	3.77052480
53	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	3.76595360
54	mitochondrial calcium ion transport (GO:0006851)	3.74089414
55	synapsis (GO:0007129)	3.67367245
56	respiratory electron transport chain (GO:0022904)	3.65509402
57	positive regulation of skeletal muscle tissue development (GO:0048643)	3.63148822
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.60674545
59	regulation of mitotic spindle checkpoint (GO:1903504)	3.60674545
60	electron transport chain (GO:0022900)	3.56955085
61	cellular component biogenesis (GO:0044085)	3.54335901
62	DNA deamination (GO:0045006)	3.51739273
63	macrophage chemotaxis (GO:0048246)	3.51423064
64	macrophage activation involved in immune response (GO:0002281)	3.49302521
65	protein neddylation (GO:0045116)	3.48003227
66	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.47468535
67	protein targeting to membrane (GO:0006612)	3.47395720
68	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.43480011
69	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	3.40366952
70	organelle membrane fusion (GO:0090174)	3.38312793
71	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.33939653
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.32396026
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.32396026
74	NADH dehydrogenase complex assembly (GO:0010257)	3.32396026
75	ATP biosynthetic process (GO:0006754)	3.32318537
76	meiosis I (GO:0007127)	3.27935712
77	mRNA catabolic process (GO:0006402)	3.25310910
78	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.25077005
79	pseudouridine synthesis (GO:0001522)	3.24912164
80	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18082922
81	cellular response to gamma radiation (GO:0071480)	3.17909400
82	regulation of striated muscle cell apoptotic process (GO:0010662)	3.17066667
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.14330683
84	cullin deneddylation (GO:0010388)	3.14122819
85	regulation of gene silencing (GO:0060968)	3.11872638
86	ribosome biogenesis (GO:0042254)	3.11780326
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.09417793
88	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.06163580
89	RNA methylation (GO:0001510)	3.03912969
90	regulation of cell cycle checkpoint (GO:1901976)	3.03031294
91	ubiquinone biosynthetic process (GO:0006744)	2.99990715
92	protein complex biogenesis (GO:0070271)	2.98685725
93	male meiosis (GO:0007140)	2.96130708
94	cornea development in camera-type eye (GO:0061303)	2.95935270
95	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.95225539
96	protein deneddylation (GO:0000338)	2.93075810
97	RNA catabolic process (GO:0006401)	2.92729475
98	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.88480785
99	intracellular protein transmembrane import (GO:0044743)	2.88204797
100	regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)	2.85216649

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.71426485
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.25344218
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.53176983
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.38645162
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.36433752
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.07215619
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.02761387
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.00114223
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.98774447
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.93379339
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91902246
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45077297
13	MYC_18940864_ChIP-ChIP_HL60_Human	2.32829360
14	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.32128629
15	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.32019521
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.24706840
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22719861
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.21502325
19	GABP_19822575_ChIP-Seq_HepG2_Human	2.16535209
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14835030
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.08672099
22	VDR_22108803_ChIP-Seq_LS180_Human	2.06437953
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.86337447
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.83246846
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.80911475
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.70222314
27	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.67787585
28	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.67060586
29	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.65710413
30	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.62833064
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.60217261
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.58868888
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.52403557
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49819354
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47072949
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46394552
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45739024
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41447457
39	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.40582991
40	AR_20517297_ChIP-Seq_VCAP_Human	1.38616140
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37781639
42	STAT1_20625510_ChIP-Seq_HELA_Human	1.36252620
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35482995
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34595586
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32253439
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31524913
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28500605
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27270039
49	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.26102971
50	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.26064462
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23320454
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.23217819
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21619503
54	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21387770
55	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19155443
56	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.18187012
57	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.18113617
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18075880
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.17536152
60	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.17308467
61	KDM5A_27292631_Chip-Seq_BREAST_Human	1.14858633
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.09688252
63	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.06367713
64	ZNF274_21170338_ChIP-Seq_K562_Hela	1.05577220
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05499712
66	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.04874800
67	E2F1_20622854_ChIP-Seq_HELA_Human	1.04609192
68	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04176216
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02300840
70	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.01606024
71	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.00896177
72	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.00896177
73	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.00896177
74	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00695907
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00411416
76	ERA_21632823_ChIP-Seq_H3396_Human	1.00342016
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99258908
78	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.98269925
79	SA1_27219007_Chip-Seq_Bcells_Human	0.97378149
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97312289
81	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96905600
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96801511
83	NCOR_22424771_ChIP-Seq_293T_Human	0.92180096
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91709097
85	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89897357
86	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.89877732
87	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.89501989
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.88638267
89	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.88065861
90	CTCF_20526341_ChIP-Seq_ESCs_Human	0.87923725
91	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.87908763
92	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.87867333
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.87645927
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86553762
95	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.86435607
96	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.86366452
97	TP53_22573176_ChIP-Seq_HFKS_Human	0.85385396
98	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.84843819
99	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.83765978
100	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.83465970

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.05662851
2	MP0008877_abnormal_DNA_methylation	4.94866987
3	MP0001188_hyperpigmentation	4.37259424
4	MP0006292_abnormal_olfactory_placode	3.51237614
5	MP0003567_abnormal_fetal_cardiomyocyte	3.48963082
6	MP0008260_abnormal_autophagy	3.47167124
7	MP0006082_CNS_inflammation	3.04368501
8	MP0000750_abnormal_muscle_regeneration	2.87464783
9	MP0003123_paternal_imprinting	2.62892094
10	MP0004185_abnormal_adipocyte_glucose	2.45124979
11	MP0009333_abnormal_splenocyte_physiolog	2.29054803
12	MP0005671_abnormal_response_to	2.22893849
13	MP0003136_yellow_coat_color	2.21356976
14	MP0003787_abnormal_imprinting	2.20434672
15	MP0002638_abnormal_pupillary_reflex	2.19727037
16	MP0002160_abnormal_reproductive_system	2.09816830
17	MP0004019_abnormal_vitamin_homeostasis	1.97997625
18	MP0005389_reproductive_system_phenotype	1.85217192
19	MP0000678_abnormal_parathyroid_gland	1.79294908
20	MP0008789_abnormal_olfactory_epithelium	1.74215873
21	MP0000049_abnormal_middle_ear	1.65242516
22	MP0004142_abnormal_muscle_tone	1.62830453
23	MP0008995_early_reproductive_senescence	1.60900917
24	MP0002653_abnormal_ependyma_morphology	1.58200753
25	MP0004145_abnormal_muscle_electrophysio	1.51918994
26	MP0002210_abnormal_sex_determination	1.50459089
27	MP0000631_abnormal_neuroendocrine_gland	1.49368342
28	MP0001915_intracranial_hemorrhage	1.46118180
29	MP0000685_abnormal_immune_system	1.36230730
30	MP0001145_abnormal_male_reproductive	1.35374848
31	MP0004957_abnormal_blastocyst_morpholog	1.31212374
32	MP0002163_abnormal_gland_morphology	1.29350845
33	MP0001764_abnormal_homeostasis	1.29344716
34	MP0001919_abnormal_reproductive_system	1.23992448
35	MP0005646_abnormal_pituitary_gland	1.23581977
36	MP0003936_abnormal_reproductive_system	1.21628767
37	MP0000372_irregular_coat_pigmentation	1.18605905
38	MP0001929_abnormal_gametogenesis	1.18376251
39	MP0003121_genomic_imprinting	1.16427711
40	MP0000383_abnormal_hair_follicle	1.15442878
41	MP0001293_anophthalmia	1.15213248
42	MP0005174_abnormal_tail_pigmentation	1.15102869
43	MP0008875_abnormal_xenobiotic_pharmacok	1.13164122
44	MP0000653_abnormal_sex_gland	1.13052753
45	MP0002095_abnormal_skin_pigmentation	1.11175169
46	MP0001243_abnormal_dermal_layer	1.08505382
47	MP0001661_extended_life_span	1.07686008
48	MP0002277_abnormal_respiratory_mucosa	1.06943512
49	MP0003646_muscle_fatigue	1.05630750
50	MP0005623_abnormal_meninges_morphology	1.04678761
51	MP0005499_abnormal_olfactory_system	1.00791312
52	MP0005394_taste/olfaction_phenotype	1.00791312
53	MP0003786_premature_aging	1.00649376
54	MP0004883_abnormal_blood_vessel	1.00644332
55	MP0003693_abnormal_embryo_hatching	0.99522937
56	MP0005083_abnormal_biliary_tract	0.98296082
57	MP0002697_abnormal_eye_size	0.95857751
58	MP0005551_abnormal_eye_electrophysiolog	0.94151333
59	MP0000026_abnormal_inner_ear	0.92933772
60	MP0002837_dystrophic_cardiac_calcinosis	0.92302586
61	MP0003937_abnormal_limbs/digits/tail_de	0.89525451
62	MP0004233_abnormal_muscle_weight	0.89205426
63	MP0002234_abnormal_pharynx_morphology	0.88938821
64	MP0002938_white_spotting	0.87644266
65	MP0001485_abnormal_pinna_reflex	0.87184625
66	MP0002876_abnormal_thyroid_physiology	0.86918755
67	MP0002138_abnormal_hepatobiliary_system	0.85997859
68	MP0003186_abnormal_redox_activity	0.83446293
69	MP0001119_abnormal_female_reproductive	0.82930829
70	MP0009785_altered_susceptibility_to	0.80460430
71	MP0002102_abnormal_ear_morphology	0.79653853
72	MP0002148_abnormal_hypersensitivity_rea	0.79022578
73	MP0006036_abnormal_mitochondrial_physio	0.77973710
74	MP0003755_abnormal_palate_morphology	0.77840697
75	MP0005195_abnormal_posterior_eye	0.77799501
76	MP0001986_abnormal_taste_sensitivity	0.77094047
77	MP0000647_abnormal_sebaceous_gland	0.76539310
78	MP0004885_abnormal_endolymph	0.76364889
79	MP0001727_abnormal_embryo_implantation	0.75328617
80	MP0003698_abnormal_male_reproductive	0.74601014
81	MP0000566_synostosis	0.74362768
82	MP0005166_decreased_susceptibility_to	0.73749584
83	MP0003315_abnormal_perineum_morphology	0.72724485
84	MP0002736_abnormal_nociception_after	0.72488324
85	MP0005670_abnormal_white_adipose	0.71550866
86	MP0005332_abnormal_amino_acid	0.69258296
87	MP0002249_abnormal_larynx_morphology	0.68897669
88	MP0009250_abnormal_appendicular_skeleto	0.68809189
89	MP0002229_neurodegeneration	0.68005516
90	MP0001542_abnormal_bone_strength	0.67604290
91	MP0008058_abnormal_DNA_repair	0.66981820
92	MP0008872_abnormal_physiological_respon	0.64272275
93	MP0005408_hypopigmentation	0.63931924
94	MP0008873_increased_physiological_sensi	0.63592288
95	MP0004043_abnormal_pH_regulation	0.63341285
96	MP0009745_abnormal_behavioral_response	0.61382035
97	MP0005197_abnormal_uvea_morphology	0.61219919
98	MP0006276_abnormal_autonomic_nervous	0.60799865
99	MP0003690_abnormal_glial_cell	0.58861960
100	MP0003195_calcinosis	0.56841700

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep palmar crease (HP:0006191)	5.58910129
2	Reticulocytopenia (HP:0001896)	4.72360943
3	Scotoma (HP:0000575)	4.31238673
4	Congenital stationary night blindness (HP:0007642)	4.27933439
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.05551877
6	Severe visual impairment (HP:0001141)	4.01796595
7	Acute necrotizing encephalopathy (HP:0006965)	3.75732429
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.68840069
9	Cortical dysplasia (HP:0002539)	3.42705958
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38688030
11	3-Methylglutaconic aciduria (HP:0003535)	3.36179020
12	Abnormal number of erythroid precursors (HP:0012131)	3.35880589
13	Macrocytic anemia (HP:0001972)	3.29889754
14	Acute encephalopathy (HP:0006846)	3.29784812
15	Mitochondrial inheritance (HP:0001427)	3.09556952
16	Central scotoma (HP:0000603)	3.09106818
17	Increased CSF lactate (HP:0002490)	2.99362790
18	Submucous cleft hard palate (HP:0000176)	2.97024492
19	Progressive macrocephaly (HP:0004481)	2.97015667
20	Septo-optic dysplasia (HP:0100842)	2.94401709
21	Hypoplasia of the radius (HP:0002984)	2.92779242
22	Microvesicular hepatic steatosis (HP:0001414)	2.89765095
23	Progressive microcephaly (HP:0000253)	2.89058071
24	Abnormality of midbrain morphology (HP:0002418)	2.88754450
25	Molar tooth sign on MRI (HP:0002419)	2.88754450
26	Absent eyebrow (HP:0002223)	2.88438444
27	Asplenia (HP:0001746)	2.87971722
28	Poor head control (HP:0002421)	2.86852694
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.79124935
30	Epidermoid cyst (HP:0200040)	2.76544842
31	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.72785866
32	Partial duplication of thumb phalanx (HP:0009944)	2.72296958
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.71054844
34	Type I transferrin isoform profile (HP:0003642)	2.66363084
35	Increased serum lactate (HP:0002151)	2.65532591
36	Syringomyelia (HP:0003396)	2.62887807
37	Spinal cord lesions (HP:0100561)	2.62887807
38	Pallor (HP:0000980)	2.57476337
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.56321092
40	Respiratory difficulties (HP:0002880)	2.56258528
41	True hermaphroditism (HP:0010459)	2.53157995
42	Impulsivity (HP:0100710)	2.53039125
43	Abnormality of the anterior horn cell (HP:0006802)	2.51827683
44	Degeneration of anterior horn cells (HP:0002398)	2.51827683
45	Curly hair (HP:0002212)	2.46296870
46	Bulbous nose (HP:0000414)	2.41758603
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.40812814
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.40812814
49	Pancreatic fibrosis (HP:0100732)	2.40373901
50	Hyperlipoproteinemia (HP:0010980)	2.33731792
51	Partial duplication of the phalanx of hand (HP:0009999)	2.31110070
52	Cerebral edema (HP:0002181)	2.30411030
53	Hepatocellular necrosis (HP:0001404)	2.30392155
54	Abnormal protein glycosylation (HP:0012346)	2.27764436
55	Abnormal glycosylation (HP:0012345)	2.27764436
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.27764436
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.27764436
58	Pachygyria (HP:0001302)	2.25109735
59	Flat capital femoral epiphysis (HP:0003370)	2.24603567
60	Forearm undergrowth (HP:0009821)	2.22175293
61	Abnormality of macular pigmentation (HP:0008002)	2.22085846
62	Abnormality of the phalanges of the hallux (HP:0010057)	2.18856248
63	Underdeveloped supraorbital ridges (HP:0009891)	2.15472364
64	Hepatic necrosis (HP:0002605)	2.13847125
65	Rib fusion (HP:0000902)	2.13606966
66	Pancreatic cysts (HP:0001737)	2.09287819
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08614249
68	Depressed nasal ridge (HP:0000457)	2.07568817
69	Lactic acidosis (HP:0003128)	2.04662429
70	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02517276
71	Abnormality of alanine metabolism (HP:0010916)	2.02517276
72	Hyperalaninemia (HP:0003348)	2.02517276
73	Dyschromatopsia (HP:0007641)	2.00151615
74	Hyperthyroidism (HP:0000836)	1.99806087
75	Optic disc pallor (HP:0000543)	1.99781525
76	Optic nerve coloboma (HP:0000588)	1.97905516
77	Absent thumb (HP:0009777)	1.96988467
78	Maternal diabetes (HP:0009800)	1.95706267
79	Renal Fanconi syndrome (HP:0001994)	1.94772604
80	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.94592250
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.94592250
82	Oligomenorrhea (HP:0000876)	1.91995838
83	Alveolar cell carcinoma (HP:0006519)	1.91947480
84	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.91792837
85	Increased intramyocellular lipid droplets (HP:0012240)	1.90108484
86	Hyperglycinemia (HP:0002154)	1.89697885
87	Hypoplastic pelvis (HP:0008839)	1.89557669
88	Slow-growing hair (HP:0002217)	1.88840128
89	Abnormality of hair growth rate (HP:0011363)	1.88840128
90	Constricted visual fields (HP:0001133)	1.88074695
91	Thickened helices (HP:0000391)	1.88066978
92	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87977658
93	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.87893523
94	Microretrognathia (HP:0000308)	1.85544762
95	Increased hepatocellular lipid droplets (HP:0006565)	1.85122835
96	11 pairs of ribs (HP:0000878)	1.84892075
97	Absent eyelashes (HP:0000561)	1.83513057
98	Villous atrophy (HP:0011473)	1.78861625
99	Abnormality of small intestinal villus morphology (HP:0011472)	1.78861625
100	Deep philtrum (HP:0002002)	1.78830865

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	7.84675868
2	IRAK4	6.26379207
3	TAF1	5.99434042
4	BRAF	4.00294952
5	ILK	3.10466310
6	MARK3	2.58830164
7	PIK3CG	2.51202989
8	CDK19	2.42265181
9	LRRK2	2.25367521
10	NME2	2.12594276
11	PNCK	2.02837131
12	PTK2	2.00558467
13	KSR1	1.96733143
14	SGK2	1.67187976
15	PRKCI	1.65159189
16	WNK4	1.63942279
17	PDK2	1.55502755
18	SGK494	1.30023104
19	SGK223	1.30023104
20	BCKDK	1.15210281
21	PIM1	1.07563745
22	ABL2	1.02299221
23	SGK3	1.01235820
24	PTK2B	0.96719771
25	MET	0.95334599
26	CDC7	0.93513606
27	NEK1	0.91629510
28	ZAK	0.90767260
29	ERN1	0.87618784
30	CHEK1	0.86610218
31	PLK2	0.83934356
32	STK16	0.83406496
33	TIE1	0.75698072
34	CSF1R	0.72394942
35	MAP3K11	0.71845113
36	STK11	0.70640111
37	GRK1	0.70477823
38	BMX	0.69256284
39	FGR	0.68302435
40	PAK1	0.67052985
41	OXSR1	0.67045804
42	CSNK1E	0.65877833
43	MAP3K9	0.63598110
44	MAPKAPK3	0.62776593
45	CSNK2A2	0.58680526
46	MAP2K6	0.58504372
47	AURKA	0.54333265
48	ADRBK2	0.53407441
49	BUB1	0.52528850
50	CAMK1	0.52123526
51	MUSK	0.50044766
52	AURKB	0.49210350
53	NME1	0.47132543
54	PLK1	0.46003882
55	PRKCZ	0.45623423
56	STK24	0.45474144
57	RIPK1	0.44200549
58	CSNK2A1	0.41778847
59	STK4	0.41316374
60	STK39	0.38366526
61	PINK1	0.38125271
62	INSRR	0.37957900
63	DYRK1B	0.37047349
64	PIM2	0.36121881
65	PRKCG	0.35386841
66	PLK4	0.35017229
67	HIPK2	0.34621129
68	SGK1	0.34489453
69	DYRK2	0.34229019
70	STK38L	0.33770758
71	DYRK3	0.33177460
72	PIK3CA	0.32636419
73	ERBB3	0.32132833
74	PRKACA	0.31176245
75	CAMK1G	0.30932842
76	ARAF	0.30742154
77	DAPK1	0.28374143
78	OBSCN	0.27139997
79	CAMK4	0.25956885
80	PRKCD	0.24368647
81	PAK3	0.24175993
82	CAMK2A	0.23670849
83	PDPK1	0.22965736
84	CDK8	0.22106922
85	BMPR1B	0.20278425
86	TLK1	0.19412397
87	CDK2	0.19230733
88	SYK	0.18370493
89	CAMK2G	0.18235007
90	CAMK2D	0.18005277
91	PRKCE	0.17743811
92	CHEK2	0.16816638
93	PRKG1	0.16766946
94	RPS6KA4	0.16305904
95	ATR	0.16169875
96	RPS6KA5	0.16001705
97	VRK2	0.15593089
98	MAP2K4	0.14724493
99	TTK	0.13862028
100	RPS6KA6	0.13813471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.22255754
2	Fatty acid elongation_Homo sapiens_hsa00062	4.76612067
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.30652050
4	Parkinsons disease_Homo sapiens_hsa05012	3.74242056
5	Sulfur relay system_Homo sapiens_hsa04122	3.32436152
6	Huntingtons disease_Homo sapiens_hsa05016	2.80655988
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60121847
8	Alzheimers disease_Homo sapiens_hsa05010	2.51252451
9	Proteasome_Homo sapiens_hsa03050	2.50402622
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.25224361
11	Regulation of autophagy_Homo sapiens_hsa04140	2.09599066
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94556583
13	Homologous recombination_Homo sapiens_hsa03440	1.81660889
14	Phototransduction_Homo sapiens_hsa04744	1.79973259
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79056483
16	Spliceosome_Homo sapiens_hsa03040	1.78459898
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.77062281
18	RNA degradation_Homo sapiens_hsa03018	1.74863708
19	RNA polymerase_Homo sapiens_hsa03020	1.71275738
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.68284175
21	Basal transcription factors_Homo sapiens_hsa03022	1.62741516
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.61696313
23	One carbon pool by folate_Homo sapiens_hsa00670	1.54685584
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32196033
25	Mismatch repair_Homo sapiens_hsa03430	1.30430897
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14360578
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13248094
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10809152
29	Protein export_Homo sapiens_hsa03060	1.08541503
30	Sulfur metabolism_Homo sapiens_hsa00920	1.03394039
31	DNA replication_Homo sapiens_hsa03030	1.02095538
32	RNA transport_Homo sapiens_hsa03013	1.01443023
33	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97245411
34	Thyroid cancer_Homo sapiens_hsa05216	0.94124090
35	Butanoate metabolism_Homo sapiens_hsa00650	0.92987763
36	Nucleotide excision repair_Homo sapiens_hsa03420	0.92768616
37	Purine metabolism_Homo sapiens_hsa00230	0.86480495
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84352582
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82485605
40	Tyrosine metabolism_Homo sapiens_hsa00350	0.78838887
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.76963379
42	Glutathione metabolism_Homo sapiens_hsa00480	0.76096882
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73366169
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71932878
45	Metabolic pathways_Homo sapiens_hsa01100	0.68534673
46	Peroxisome_Homo sapiens_hsa04146	0.66200220
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.63658174
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63232776
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63090377
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61647117
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60554061
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.57097105
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56705541
54	Asthma_Homo sapiens_hsa05310	0.56422625
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54471562
56	Propanoate metabolism_Homo sapiens_hsa00640	0.53692636
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52465584
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.51711345
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.51103409
60	Folate biosynthesis_Homo sapiens_hsa00790	0.50101274
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.47441822
62	Melanoma_Homo sapiens_hsa05218	0.47159148
63	Base excision repair_Homo sapiens_hsa03410	0.45863782
64	Allograft rejection_Homo sapiens_hsa05330	0.44496090
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44202113
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43197382
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40845686
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36628063
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36376041
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.35882621
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35646543
72	Caffeine metabolism_Homo sapiens_hsa00232	0.32322913
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32135122
74	Retinol metabolism_Homo sapiens_hsa00830	0.31340079
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31100215
76	Olfactory transduction_Homo sapiens_hsa04740	0.28648495
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28502512
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.27955963
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.27717479
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26375928
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26213038
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20092140
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.19893124
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.13571510
85	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.11580189
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.11489169
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.10949936
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.10359121
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.10161156
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.09572748
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.07328978
92	Leishmaniasis_Homo sapiens_hsa05140	0.07268545
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.07139999
94	ErbB signaling pathway_Homo sapiens_hsa04012	0.06735046
95	Bladder cancer_Homo sapiens_hsa05219	0.06707127
96	Glioma_Homo sapiens_hsa05214	0.06654114
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.05386750
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.04898991
99	Pertussis_Homo sapiens_hsa05133	0.04688225
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.04326899

RPS12P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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