RPS12P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.59469714
2translational termination (GO:0006415)9.18038264
3ribosomal small subunit biogenesis (GO:0042274)8.89845667
4ribosomal small subunit assembly (GO:0000028)8.00462109
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.74052625
6translational elongation (GO:0006414)7.66997723
7cotranslational protein targeting to membrane (GO:0006613)7.60509212
8protein targeting to ER (GO:0045047)7.58710013
9establishment of protein localization to endoplasmic reticulum (GO:0072599)7.25772637
10protein localization to endoplasmic reticulum (GO:0070972)7.16276773
11cellular protein complex disassembly (GO:0043624)6.91933759
12maturation of SSU-rRNA (GO:0030490)6.90819996
13viral life cycle (GO:0019058)6.75670332
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.74541832
15activation of MAPKKK activity (GO:0000185)6.39917582
16chaperone-mediated protein transport (GO:0072321)6.29651249
17translational initiation (GO:0006413)6.04888694
18protein complex disassembly (GO:0043241)5.76659450
19ATP synthesis coupled proton transport (GO:0015986)5.66428517
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.66428517
21macromolecular complex disassembly (GO:0032984)5.40338440
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.38972024
23negative regulation of mast cell activation (GO:0033004)5.27777089
24ribosomal large subunit biogenesis (GO:0042273)5.17752016
25protein targeting to membrane (GO:0006612)5.15978454
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.07590014
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.89394275
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.89394275
29NADH dehydrogenase complex assembly (GO:0010257)4.89394275
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.82339945
31nuclear-transcribed mRNA catabolic process (GO:0000956)4.80312232
32translation (GO:0006412)4.78119429
33pyrimidine nucleotide catabolic process (GO:0006244)4.62058689
34mRNA catabolic process (GO:0006402)4.53208860
35positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.33368248
36protein complex biogenesis (GO:0070271)4.28919371
37leukocyte aggregation (GO:0070486)4.26637464
38respiratory electron transport chain (GO:0022904)4.12848178
39electron transport chain (GO:0022900)4.07604188
40DNA deamination (GO:0045006)4.06021996
41water-soluble vitamin biosynthetic process (GO:0042364)4.05889927
42RNA catabolic process (GO:0006401)4.03418473
43regulation of cilium movement (GO:0003352)4.02991714
44termination of RNA polymerase III transcription (GO:0006386)4.02273905
45transcription elongation from RNA polymerase III promoter (GO:0006385)4.02273905
46protein neddylation (GO:0045116)3.99743388
47mitochondrial respiratory chain complex assembly (GO:0033108)3.89563111
48cellular component biogenesis (GO:0044085)3.85811748
49ribonucleoprotein complex biogenesis (GO:0022613)3.83549661
50regulation of activation of Janus kinase activity (GO:0010533)3.73425716
51substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.67330626
52substrate-independent telencephalic tangential migration (GO:0021826)3.67330626
53nonmotile primary cilium assembly (GO:0035058)3.66485477
54positive regulation of vascular permeability (GO:0043117)3.66148894
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49545782
56establishment of protein localization to membrane (GO:0090150)3.47210622
57rRNA transcription (GO:0009303)3.45244797
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.39078268
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39008939
60protein targeting (GO:0006605)3.34294673
61GTP biosynthetic process (GO:0006183)3.33144204
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32399217
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.26926863
64base-excision repair, AP site formation (GO:0006285)3.23089547
65pseudouridine synthesis (GO:0001522)3.22857041
66pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20530664
67establishment of protein localization to organelle (GO:0072594)3.16890146
68positive regulation of signal transduction by p53 class mediator (GO:1901798)3.11950704
69rRNA metabolic process (GO:0016072)3.11539879
70behavioral response to nicotine (GO:0035095)3.11351852
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11342451
72transcription from RNA polymerase I promoter (GO:0006360)3.09798905
73somite development (GO:0061053)3.09351107
74ATP biosynthetic process (GO:0006754)3.04457688
75negative regulation of appetite (GO:0032099)3.02053300
76negative regulation of response to food (GO:0032096)3.02053300
77purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01839793
78termination of RNA polymerase I transcription (GO:0006363)3.01406459
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00974717
80iron-sulfur cluster assembly (GO:0016226)2.98831296
81metallo-sulfur cluster assembly (GO:0031163)2.98831296
82transcription elongation from RNA polymerase I promoter (GO:0006362)2.98046123
83UTP biosynthetic process (GO:0006228)2.95163242
84kynurenine metabolic process (GO:0070189)2.84753204
85negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81310177
86protein localization to membrane (GO:0072657)2.79994849
87regulation of microtubule-based movement (GO:0060632)2.78163491
88nucleotide-excision repair, DNA damage removal (GO:0000718)2.78095268
89DNA excision (GO:0044349)2.78095268
90peptidyl-histidine modification (GO:0018202)2.77577283
91rRNA processing (GO:0006364)2.77526844
92hydrogen ion transmembrane transport (GO:1902600)2.73700852
93epithelial cilium movement (GO:0003351)2.72704408
94protein targeting to mitochondrion (GO:0006626)2.72107669
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70709187
96deoxyribonucleotide catabolic process (GO:0009264)2.70276281
97positive regulation of T cell apoptotic process (GO:0070234)2.68817684
98resolution of meiotic recombination intermediates (GO:0000712)2.68776387
99forebrain morphogenesis (GO:0048853)2.65076002
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62606309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.86700996
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54899726
3EZH2_22144423_ChIP-Seq_EOC_Human3.54466868
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.16482216
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13715121
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.96927651
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.95097538
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85483925
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69161029
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46854167
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46440445
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38597479
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36760121
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.34578794
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31749880
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20009658
17XRN2_22483619_ChIP-Seq_HELA_Human2.16609433
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.09925249
19POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00952633
20TTF2_22483619_ChIP-Seq_HELA_Human1.90047161
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84503642
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83715200
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.75690774
24FOXP3_21729870_ChIP-Seq_TREG_Human1.75200494
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.72457430
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71838215
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.71836061
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66672522
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63751743
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54710303
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53855199
32TP53_22573176_ChIP-Seq_HFKS_Human1.52738985
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.52022233
34VDR_23849224_ChIP-Seq_CD4+_Human1.51288168
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48829030
36STAT1_20625510_ChIP-Seq_HELA_Human1.47706495
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46743537
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45175811
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.44602659
40TAF2_19829295_ChIP-Seq_ESCs_Human1.42063369
41VDR_22108803_ChIP-Seq_LS180_Human1.40640595
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40279854
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36947773
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36574877
45CTCF_20526341_ChIP-Seq_ESCs_Human1.36334570
46ELK1_19687146_ChIP-ChIP_HELA_Human1.35119000
47GABP_19822575_ChIP-Seq_HepG2_Human1.33034700
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32852487
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.29375790
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.28210702
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27621458
52MYC_18940864_ChIP-ChIP_HL60_Human1.27399918
53E2F1_20622854_ChIP-Seq_HELA_Human1.26557038
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.25072104
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21034914
56NANOG_20526341_ChIP-Seq_ESCs_Human1.20792722
57SA1_27219007_Chip-Seq_Bcells_Human1.19525603
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.19294910
59BCL6_27268052_Chip-Seq_Bcells_Human1.17909488
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17525701
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17515517
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17180681
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16999184
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.16218036
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.15911889
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.14214472
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14133482
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13781632
69P68_20966046_ChIP-Seq_HELA_Human1.10925103
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.09353962
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.08343481
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08343481
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08206156
74AR_20517297_ChIP-Seq_VCAP_Human1.07758152
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06735265
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06358569
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.05802816
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05790677
79EWS_26573619_Chip-Seq_HEK293_Human1.05633210
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04618218
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02359968
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02023940
83P53_21459846_ChIP-Seq_SAOS-2_Human1.00662575
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99681455
85CTCF_27219007_Chip-Seq_Bcells_Human0.98491811
86ERA_21632823_ChIP-Seq_H3396_Human0.98254480
87NCOR_22424771_ChIP-Seq_293T_Human0.97888413
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.97113084
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97107382
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97107382
91GATA3_21867929_ChIP-Seq_TH1_Mouse0.95725750
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95615371
93ERG_20517297_ChIP-Seq_VCAP_Human0.94115698
94SOX2_21211035_ChIP-Seq_LN229_Human0.93463998
95CIITA_25753668_ChIP-Seq_RAJI_Human0.90676216
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90477754
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90169457
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88421048
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.87219880
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87190779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.69764388
2MP0005623_abnormal_meninges_morphology4.91789313
3MP0003646_muscle_fatigue4.47890108
4MP0006292_abnormal_olfactory_placode4.13269207
5MP0002163_abnormal_gland_morphology2.78562007
6MP0002938_white_spotting2.73192521
7MP0002837_dystrophic_cardiac_calcinosis2.49177357
8MP0000750_abnormal_muscle_regeneration2.41960929
9MP0008789_abnormal_olfactory_epithelium2.39671645
10MP0004142_abnormal_muscle_tone2.09567057
11MP0003786_premature_aging1.93418809
12MP0009384_cardiac_valve_regurgitation1.92652445
13MP0004147_increased_porphyrin_level1.92473907
14MP0005499_abnormal_olfactory_system1.90487600
15MP0005394_taste/olfaction_phenotype1.90487600
16MP0005551_abnormal_eye_electrophysiolog1.85450323
17MP0003787_abnormal_imprinting1.82494835
18MP0003186_abnormal_redox_activity1.74998035
19MP0003011_delayed_dark_adaptation1.69589198
20MP0002102_abnormal_ear_morphology1.62630133
21MP0005389_reproductive_system_phenotype1.61736026
22MP0000049_abnormal_middle_ear1.61147278
23MP0002638_abnormal_pupillary_reflex1.60361175
24MP0002095_abnormal_skin_pigmentation1.54812559
25MP0004885_abnormal_endolymph1.50927555
26MP0002160_abnormal_reproductive_system1.47725126
27MP0001529_abnormal_vocalization1.47030954
28MP0005379_endocrine/exocrine_gland_phen1.45348463
29MP0003123_paternal_imprinting1.41103098
30MP0005377_hearing/vestibular/ear_phenot1.40209286
31MP0003878_abnormal_ear_physiology1.40209286
32MP0002736_abnormal_nociception_after1.38689461
33MP0006276_abnormal_autonomic_nervous1.33960197
34MP0002277_abnormal_respiratory_mucosa1.31005217
35MP0001919_abnormal_reproductive_system1.30559311
36MP0003385_abnormal_body_wall1.30068674
37MP0008775_abnormal_heart_ventricle1.26330852
38MP0005646_abnormal_pituitary_gland1.25747700
39MP0005671_abnormal_response_to1.24744866
40MP0008875_abnormal_xenobiotic_pharmacok1.22288784
41MP0001968_abnormal_touch/_nociception1.21454829
42MP0001293_anophthalmia1.18279733
43MP0001440_abnormal_grooming_behavior1.15042665
44MP0001984_abnormal_olfaction1.14430995
45MP0005195_abnormal_posterior_eye1.13121802
46MP0003119_abnormal_digestive_system1.12710280
47MP0000631_abnormal_neuroendocrine_gland1.10432244
48MP0000762_abnormal_tongue_morphology1.08053272
49MP0001905_abnormal_dopamine_level1.07700267
50MP0002234_abnormal_pharynx_morphology1.06959187
51MP0002177_abnormal_outer_ear1.06701956
52MP0009053_abnormal_anal_canal1.06491090
53MP0003755_abnormal_palate_morphology1.06104487
54MP0000343_altered_response_to1.04213742
55MP0006036_abnormal_mitochondrial_physio1.03092280
56MP0000678_abnormal_parathyroid_gland0.99318133
57MP0008877_abnormal_DNA_methylation0.98495452
58MP0004130_abnormal_muscle_cell0.98307213
59MP0008872_abnormal_physiological_respon0.97919044
60MP0002653_abnormal_ependyma_morphology0.97367318
61MP0000013_abnormal_adipose_tissue0.96647554
62MP0009046_muscle_twitch0.96193887
63MP0008058_abnormal_DNA_repair0.92804599
64MP0000026_abnormal_inner_ear0.92250911
65MP0002233_abnormal_nose_morphology0.91460559
66MP0001485_abnormal_pinna_reflex0.91009014
67MP0002067_abnormal_sensory_capabilities0.90251807
68MP0002752_abnormal_somatic_nervous0.89444117
69MP0002272_abnormal_nervous_system0.88290855
70MP0002876_abnormal_thyroid_physiology0.87435948
71MP0003137_abnormal_impulse_conducting0.84695195
72MP0002210_abnormal_sex_determination0.83962301
73MP0003938_abnormal_ear_development0.81072526
74MP0002249_abnormal_larynx_morphology0.80186451
75MP0006072_abnormal_retinal_apoptosis0.79731112
76MP0001324_abnormal_eye_pigmentation0.77579745
77MP0009250_abnormal_appendicular_skeleto0.77062809
78MP0001986_abnormal_taste_sensitivity0.76652724
79MP0005410_abnormal_fertilization0.75444544
80MP0005645_abnormal_hypothalamus_physiol0.74686071
81MP0005636_abnormal_mineral_homeostasis0.74497179
82MP0009745_abnormal_behavioral_response0.73404823
83MP0000015_abnormal_ear_pigmentation0.73048366
84MP0000858_altered_metastatic_potential0.71086950
85MP0010307_abnormal_tumor_latency0.70765498
86MP0004742_abnormal_vestibular_system0.69445479
87MP0004019_abnormal_vitamin_homeostasis0.68278976
88MP0003879_abnormal_hair_cell0.67311499
89MP0003195_calcinosis0.66780150
90MP0003115_abnormal_respiratory_system0.66657569
91MP0005332_abnormal_amino_acid0.66467071
92MP0009764_decreased_sensitivity_to0.65774086
93MP0003121_genomic_imprinting0.65057727
94MP0003698_abnormal_male_reproductive0.64075963
95MP0005408_hypopigmentation0.63793518
96MP0002116_abnormal_craniofacial_bone0.61057677
97MP0003122_maternal_imprinting0.60969907
98MP0005174_abnormal_tail_pigmentation0.58489535
99MP0002572_abnormal_emotion/affect_behav0.58304375
100MP0002269_muscular_atrophy0.56698172

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)7.61844409
2Type II lissencephaly (HP:0007260)7.41990665
3Retinal atrophy (HP:0001105)6.60193073
4Hypoplasia of the pons (HP:0012110)5.64332458
5Retinal dysplasia (HP:0007973)5.45617541
6Decreased electroretinogram (ERG) amplitude (HP:0000654)5.27089958
7Abnormality of the pons (HP:0007361)5.03065845
8Acute necrotizing encephalopathy (HP:0006965)4.72612277
9Pallor (HP:0000980)4.48725294
10Abnormal mitochondria in muscle tissue (HP:0008316)4.22660925
11Fatigue (HP:0012378)4.18426615
12Abnormality of cells of the erythroid lineage (HP:0012130)4.11004373
13Reticulocytopenia (HP:0001896)4.04069751
14Abolished electroretinogram (ERG) (HP:0000550)3.98483618
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.94328944
16Acute encephalopathy (HP:0006846)3.87064631
17Progressive macrocephaly (HP:0004481)3.79874225
18Buphthalmos (HP:0000557)3.79408336
19Macrocytic anemia (HP:0001972)3.75141596
20Molar tooth sign on MRI (HP:0002419)3.55994126
21Abnormality of midbrain morphology (HP:0002418)3.55994126
223-Methylglutaconic aciduria (HP:0003535)3.48943934
23Mitochondrial inheritance (HP:0001427)3.45942728
24Severe muscular hypotonia (HP:0006829)3.28554625
25Abnormal number of erythroid precursors (HP:0012131)3.22738896
26Abnormality of DNA repair (HP:0003254)3.20216332
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12785411
28Megalocornea (HP:0000485)3.09007946
29Increased CSF lactate (HP:0002490)3.05254044
30Lissencephaly (HP:0001339)2.93753417
31Difficulty climbing stairs (HP:0003551)2.84445128
32Cerebral edema (HP:0002181)2.80218148
33Abnormal hemoglobin (HP:0011902)2.77353353
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62801990
35Nephronophthisis (HP:0000090)2.62680416
36Hyperglycinemia (HP:0002154)2.57123217
37Hepatocellular necrosis (HP:0001404)2.52062018
38Entropion (HP:0000621)2.47857699
39Poikiloderma (HP:0001029)2.46023130
40Colon cancer (HP:0003003)2.41166435
41Medial flaring of the eyebrow (HP:0010747)2.32500918
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29930991
43Stenosis of the external auditory canal (HP:0000402)2.28008198
44Abnormal rod and cone electroretinograms (HP:0008323)2.26750557
45Pachygyria (HP:0001302)2.21716902
46Increased IgM level (HP:0003496)2.20979444
47Pancreatic cysts (HP:0001737)2.20296831
48Absent/shortened dynein arms (HP:0200106)2.18622094
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.18622094
50Congenital glaucoma (HP:0001087)2.16500392
51Hepatic necrosis (HP:0002605)2.16208048
52Meningocele (HP:0002435)2.15318674
53Generalized muscle weakness (HP:0003324)2.14657393
54Increased hepatocellular lipid droplets (HP:0006565)2.13937342
55True hermaphroditism (HP:0010459)2.13767287
56Lipid accumulation in hepatocytes (HP:0006561)2.13642636
57Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.06335514
58Abnormality of the vitreous humor (HP:0004327)2.06051103
59Pancreatic fibrosis (HP:0100732)2.05554365
60Sclerocornea (HP:0000647)2.00536048
61Optic disc pallor (HP:0000543)1.99768124
62Leukodystrophy (HP:0002415)1.97145540
63IgG deficiency (HP:0004315)1.96354860
64Generalized hypotonia (HP:0001290)1.96217796
65Asplenia (HP:0001746)1.95765262
66Increased intramyocellular lipid droplets (HP:0012240)1.95693788
67Abnormality of the heme biosynthetic pathway (HP:0010472)1.92884807
68Respiratory failure (HP:0002878)1.92884088
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.92846081
70Absent thumb (HP:0009777)1.91520273
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90786138
72Decreased central vision (HP:0007663)1.88746260
73Anencephaly (HP:0002323)1.84614428
74Abnormality of the renal medulla (HP:0100957)1.82281930
75Fragile nails (HP:0001808)1.80858698
76Exercise intolerance (HP:0003546)1.78561534
77Holoprosencephaly (HP:0001360)1.78054638
78Polydipsia (HP:0001959)1.77248305
79Abnormal drinking behavior (HP:0030082)1.77248305
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76235256
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76235256
82Abnormal respiratory motile cilium morphology (HP:0005938)1.76183027
83Abnormal respiratory epithelium morphology (HP:0012253)1.76183027
84Renal Fanconi syndrome (HP:0001994)1.73947290
85Chronic hepatic failure (HP:0100626)1.72186096
86Increased muscle lipid content (HP:0009058)1.71877452
87Impulsivity (HP:0100710)1.71801309
88Testicular atrophy (HP:0000029)1.71596243
89Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71453494
90Hypoplasia of the brainstem (HP:0002365)1.71453494
91Non-midline cleft lip (HP:0100335)1.71341033
92Methylmalonic acidemia (HP:0002912)1.71210001
93Pendular nystagmus (HP:0012043)1.69976519
94Diastasis recti (HP:0001540)1.69687428
95Increased serum lactate (HP:0002151)1.68093229
96Decreased subcutaneous fat (HP:0001002)1.68030702
97Congenital stationary night blindness (HP:0007642)1.67863971
98Lactic acidosis (HP:0003128)1.66335428
99Rectal prolapse (HP:0002035)1.64520288
100Erythroderma (HP:0001019)1.64280936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.79031073
2STK104.68306617
3NME23.87744179
4LIMK12.64811060
5STK162.57718415
6CAMKK22.44866823
7BCKDK2.37921212
8PIM12.33488632
9STK112.25419397
10TXK2.20304114
11TLK12.14701532
12ZAK2.11041132
13MAP4K12.05580095
14MAP3K112.05308580
15ADRBK21.96557609
16GRK11.92285930
17CDK81.81110951
18PIK3CA1.78104823
19BRSK11.66801178
20DYRK21.64210685
21WNK41.56360974
22CDK191.48970655
23LRRK21.48257183
24TIE11.46782060
25PTK2B1.40862398
26ABL21.36348602
27CAMKK11.35435936
28CDC71.35130077
29RPS6KA51.29944126
30MAP4K21.23410237
31AURKA1.18427796
32WNK31.17175663
33PRKCH1.04085631
34CDC42BPA1.04025333
35PIM21.01362137
36MAP2K20.99631937
37INSRR0.98791255
38CAMK10.96961619
39BRSK20.95692908
40NTRK30.90064672
41IKBKB0.89932693
42PRKCG0.82093388
43PDK20.78689872
44PRKCQ0.78598830
45CSNK2A20.76287982
46CHEK20.75524815
47EPHA40.73903335
48FRK0.73326256
49MAP3K40.72219473
50LMTK20.69064650
51RPS6KA60.67836837
52ARAF0.66763258
53NEK10.63949790
54NLK0.63464448
55STK390.61445793
56CLK10.60441579
57EPHB20.60060209
58MAP3K130.59527351
59ILK0.56162364
60NTRK20.56028286
61MELK0.55282453
62CSNK2A10.54764140
63DAPK30.54708474
64PLK10.53561145
65OBSCN0.53421569
66DAPK20.51836176
67RPS6KC10.50881445
68RPS6KL10.50881445
69ADRBK10.50821593
70PRKACA0.50266978
71PKN10.46543970
72PLK40.45167499
73AURKB0.44507643
74MAPKAPK50.44079066
75ATR0.43311916
76CAMK40.40348746
77OXSR10.39270816
78PASK0.38876105
79MST40.38284807
80MAP2K70.35931990
81NUAK10.34346688
82CAMK1D0.33407137
83MAPK130.32448379
84PRKCI0.32196673
85MUSK0.30646490
86CSNK1G30.30432092
87CSNK1E0.29708078
88GRK70.28793383
89LCK0.28731582
90CHEK10.28299006
91GSK3A0.28262830
92PINK10.28026133
93BRAF0.27864123
94CSNK1G20.27389313
95SIK20.26751354
96SGK10.26575680
97PRKCZ0.25768954
98PRKCA0.25509264
99CSNK1D0.24304243
100PRKACG0.23887630

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.89723078
2Oxidative phosphorylation_Homo sapiens_hsa001904.76761842
3Parkinsons disease_Homo sapiens_hsa050123.96139611
4Huntingtons disease_Homo sapiens_hsa050162.88078055
5RNA polymerase_Homo sapiens_hsa030202.81827441
6Alzheimers disease_Homo sapiens_hsa050102.72744390
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71416975
8Cardiac muscle contraction_Homo sapiens_hsa042602.61667101
9Sulfur relay system_Homo sapiens_hsa041222.18190111
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.11197351
11One carbon pool by folate_Homo sapiens_hsa006702.04740072
12Protein export_Homo sapiens_hsa030601.94837545
13Asthma_Homo sapiens_hsa053101.93432443
14Nucleotide excision repair_Homo sapiens_hsa034201.65782171
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55640402
16Allograft rejection_Homo sapiens_hsa053301.55370391
17Autoimmune thyroid disease_Homo sapiens_hsa053201.54885655
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48630103
19Linoleic acid metabolism_Homo sapiens_hsa005911.46262485
20RNA degradation_Homo sapiens_hsa030181.45408140
21Pyrimidine metabolism_Homo sapiens_hsa002401.40574888
22Basal transcription factors_Homo sapiens_hsa030221.38456360
23Proteasome_Homo sapiens_hsa030501.36164030
24Graft-versus-host disease_Homo sapiens_hsa053321.35874364
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.29684760
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28439684
27Homologous recombination_Homo sapiens_hsa034401.17867424
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14575376
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09974061
30Nicotine addiction_Homo sapiens_hsa050331.08289547
31Arachidonic acid metabolism_Homo sapiens_hsa005901.02098708
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98846762
33NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92033964
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89515594
35Regulation of autophagy_Homo sapiens_hsa041400.86926524
36Type I diabetes mellitus_Homo sapiens_hsa049400.82775993
37Base excision repair_Homo sapiens_hsa034100.79232046
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79120711
39Phototransduction_Homo sapiens_hsa047440.78856891
40Fanconi anemia pathway_Homo sapiens_hsa034600.76702885
41DNA replication_Homo sapiens_hsa030300.75495669
42Systemic lupus erythematosus_Homo sapiens_hsa053220.75248772
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74436585
44Vitamin B6 metabolism_Homo sapiens_hsa007500.73560938
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.72953536
46Metabolic pathways_Homo sapiens_hsa011000.67959957
47Spliceosome_Homo sapiens_hsa030400.67767066
48Purine metabolism_Homo sapiens_hsa002300.66499358
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65429710
50Folate biosynthesis_Homo sapiens_hsa007900.65386798
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.64442649
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62669601
53Tryptophan metabolism_Homo sapiens_hsa003800.62315569
54Collecting duct acid secretion_Homo sapiens_hsa049660.58614787
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58010516
56Chemical carcinogenesis_Homo sapiens_hsa052040.57561761
57Olfactory transduction_Homo sapiens_hsa047400.54875215
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54206954
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.53080472
60Rheumatoid arthritis_Homo sapiens_hsa053230.52433673
61Fat digestion and absorption_Homo sapiens_hsa049750.52210404
62Sulfur metabolism_Homo sapiens_hsa009200.50373370
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49506902
64RNA transport_Homo sapiens_hsa030130.48670174
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47615280
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45794117
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44175007
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43189120
69Basal cell carcinoma_Homo sapiens_hsa052170.41404812
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41273637
71Leishmaniasis_Homo sapiens_hsa051400.39238952
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38183542
73Mismatch repair_Homo sapiens_hsa034300.37237972
74Mineral absorption_Homo sapiens_hsa049780.35797102
75Retinol metabolism_Homo sapiens_hsa008300.35211920
76Ether lipid metabolism_Homo sapiens_hsa005650.34798363
77p53 signaling pathway_Homo sapiens_hsa041150.33792798
78Glutathione metabolism_Homo sapiens_hsa004800.32021728
79Caffeine metabolism_Homo sapiens_hsa002320.29212483
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28830788
81Tyrosine metabolism_Homo sapiens_hsa003500.27349458
82Primary immunodeficiency_Homo sapiens_hsa053400.26572069
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.26434437
84Peroxisome_Homo sapiens_hsa041460.26204882
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25729906
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24109744
87Epstein-Barr virus infection_Homo sapiens_hsa051690.23981770
88Morphine addiction_Homo sapiens_hsa050320.23023614
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22752222
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21842886
91Ovarian steroidogenesis_Homo sapiens_hsa049130.21289089
92Phenylalanine metabolism_Homo sapiens_hsa003600.21159121
93Antigen processing and presentation_Homo sapiens_hsa046120.20036986
94Nitrogen metabolism_Homo sapiens_hsa009100.19073495
95Butanoate metabolism_Homo sapiens_hsa006500.18944359
96Alcoholism_Homo sapiens_hsa050340.18915331
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.18206596
98Serotonergic synapse_Homo sapiens_hsa047260.16916054
99Fatty acid elongation_Homo sapiens_hsa000620.16575556
100Insulin secretion_Homo sapiens_hsa049110.16558936

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