RPS12P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.22663761
2translational termination (GO:0006415)8.79550012
3ribosomal small subunit biogenesis (GO:0042274)8.47207488
4ribosomal small subunit assembly (GO:0000028)8.13425119
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.48687198
6cotranslational protein targeting to membrane (GO:0006613)7.35958843
7protein targeting to ER (GO:0045047)7.34666861
8translational elongation (GO:0006414)7.33326998
9maturation of SSU-rRNA (GO:0030490)7.24688091
10establishment of protein localization to endoplasmic reticulum (GO:0072599)7.02669117
11protein localization to endoplasmic reticulum (GO:0070972)6.86234722
12viral life cycle (GO:0019058)6.67171893
13cellular protein complex disassembly (GO:0043624)6.53938087
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.31056299
15ATP synthesis coupled proton transport (GO:0015986)5.74125076
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.74125076
17translational initiation (GO:0006413)5.72871638
18behavioral response to nicotine (GO:0035095)5.68896861
19chaperone-mediated protein transport (GO:0072321)5.61447599
20protein complex disassembly (GO:0043241)5.48832772
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.47440817
22ribosomal large subunit biogenesis (GO:0042273)5.34884001
23macromolecular complex disassembly (GO:0032984)5.15237500
24protein targeting to membrane (GO:0006612)4.85732063
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79580473
26translation (GO:0006412)4.62626190
27positive regulation of prostaglandin secretion (GO:0032308)4.60650978
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.48749633
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.41841988
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.34747343
31NADH dehydrogenase complex assembly (GO:0010257)4.34747343
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34747343
33electron transport chain (GO:0022900)4.27963032
34respiratory electron transport chain (GO:0022904)4.24523712
35mRNA catabolic process (GO:0006402)4.16030305
36protein neddylation (GO:0045116)4.15652192
37protein complex biogenesis (GO:0070271)4.13222276
38ribonucleoprotein complex biogenesis (GO:0022613)4.12759182
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.10869051
40cellular component biogenesis (GO:0044085)3.89560513
41water-soluble vitamin biosynthetic process (GO:0042364)3.87727873
42mitochondrial respiratory chain complex assembly (GO:0033108)3.75929803
43RNA catabolic process (GO:0006401)3.69151795
44preassembly of GPI anchor in ER membrane (GO:0016254)3.61231078
45regulation of prostaglandin secretion (GO:0032306)3.61215898
46DNA deamination (GO:0045006)3.60484910
47nonmotile primary cilium assembly (GO:0035058)3.50044646
48pyrimidine nucleotide catabolic process (GO:0006244)3.43644959
49positive regulation of icosanoid secretion (GO:0032305)3.41194396
50positive regulation of fatty acid transport (GO:2000193)3.39751127
51ATP biosynthetic process (GO:0006754)3.37435831
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30153199
53establishment of protein localization to membrane (GO:0090150)3.28564497
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.27028146
55protein targeting (GO:0006605)3.23102699
56peptidyl-histidine modification (GO:0018202)3.21192536
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20632143
58rRNA processing (GO:0006364)3.14996051
59establishment of protein localization to organelle (GO:0072594)3.07938964
60GTP biosynthetic process (GO:0006183)3.07091531
61rRNA metabolic process (GO:0016072)3.05357867
62respiratory chain complex IV assembly (GO:0008535)2.99994622
63hydrogen ion transmembrane transport (GO:1902600)2.97393357
64protein targeting to mitochondrion (GO:0006626)2.93671254
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89895119
66establishment of protein localization to mitochondrion (GO:0072655)2.83888136
67ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82105791
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80463964
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80463964
70pseudouridine synthesis (GO:0001522)2.80385309
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77116965
72base-excision repair, AP site formation (GO:0006285)2.76590824
73axoneme assembly (GO:0035082)2.72753767
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69080759
75protein-cofactor linkage (GO:0018065)2.67771073
76regulation of appetite (GO:0032098)2.67299184
77GPI anchor biosynthetic process (GO:0006506)2.67190921
78proton transport (GO:0015992)2.65430822
79GPI anchor metabolic process (GO:0006505)2.65404989
80termination of RNA polymerase III transcription (GO:0006386)2.65170449
81transcription elongation from RNA polymerase III promoter (GO:0006385)2.65170449
82intracellular protein transmembrane import (GO:0044743)2.64192090
83hydrogen transport (GO:0006818)2.62392258
84negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60344685
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59915768
86cytochrome complex assembly (GO:0017004)2.59787414
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59484232
88protein localization to mitochondrion (GO:0070585)2.58992185
89tRNA processing (GO:0008033)2.56864780
90protein localization to membrane (GO:0072657)2.51147241
91positive regulation of respiratory burst (GO:0060267)2.50596020
92protein polyglutamylation (GO:0018095)2.50341029
93UTP biosynthetic process (GO:0006228)2.47112400
94ncRNA 3-end processing (GO:0043628)2.45327562
95nucleoside triphosphate biosynthetic process (GO:0009142)2.43477036
96metallo-sulfur cluster assembly (GO:0031163)2.42692705
97iron-sulfur cluster assembly (GO:0016226)2.42692705
98synaptic transmission, cholinergic (GO:0007271)2.41883930
99piRNA metabolic process (GO:0034587)2.41225217
100positive regulation of protein homooligomerization (GO:0032464)2.41051095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81413912
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.82528283
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57839004
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29880292
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19552375
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.98603228
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96812555
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.73564045
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45769508
10ZNF274_21170338_ChIP-Seq_K562_Hela2.44272740
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.43234106
12VDR_22108803_ChIP-Seq_LS180_Human2.39506003
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36565370
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28761250
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23551633
16VDR_23849224_ChIP-Seq_CD4+_Human2.02040530
17MYC_18940864_ChIP-ChIP_HL60_Human1.94296567
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.89764520
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86377680
20ELK1_19687146_ChIP-ChIP_HELA_Human1.83887630
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83737722
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82602539
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81409502
24IGF1R_20145208_ChIP-Seq_DFB_Human1.76759003
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72906489
26FOXP3_21729870_ChIP-Seq_TREG_Human1.66512124
27TP53_22573176_ChIP-Seq_HFKS_Human1.61625684
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59536422
29TTF2_22483619_ChIP-Seq_HELA_Human1.57473593
30IRF1_19129219_ChIP-ChIP_H3396_Human1.54526378
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54143871
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.47727055
33EWS_26573619_Chip-Seq_HEK293_Human1.47344385
34FUS_26573619_Chip-Seq_HEK293_Human1.44287361
35NCOR_22424771_ChIP-Seq_293T_Human1.42751861
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41436702
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40192435
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.35286901
39XRN2_22483619_ChIP-Seq_HELA_Human1.34683505
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.34649973
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30974204
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30769501
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.30209773
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26274767
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.26274767
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26086444
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25640841
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25597649
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.24467927
50NANOG_20526341_ChIP-Seq_ESCs_Human1.23503979
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21122187
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20576154
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.19205439
54TAF2_19829295_ChIP-Seq_ESCs_Human1.16724873
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16474508
56CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16343781
57AR_20517297_ChIP-Seq_VCAP_Human1.16176912
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15238859
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13560394
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.13526072
61GABP_19822575_ChIP-Seq_HepG2_Human1.13205554
62ERA_21632823_ChIP-Seq_H3396_Human1.11905987
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.09974479
64MYC_19829295_ChIP-Seq_ESCs_Human1.09144290
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09067048
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08620960
67FOXH1_21741376_ChIP-Seq_ESCs_Human1.07814901
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07235725
69RNF2_27304074_Chip-Seq_NSC_Mouse1.06642924
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05662244
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.05619574
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05033654
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04466602
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04159944
75REST_21632747_ChIP-Seq_MESCs_Mouse1.03618566
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03577292
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03109246
78HOXB7_26014856_ChIP-Seq_BT474_Human1.02983514
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00565199
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.00538089
81STAT1_20625510_ChIP-Seq_HELA_Human0.97254736
82P53_21459846_ChIP-Seq_SAOS-2_Human0.97075991
83JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96865076
84SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95617328
85NANOG_19829295_ChIP-Seq_ESCs_Human0.92767037
86SOX2_19829295_ChIP-Seq_ESCs_Human0.92767037
87CTCF_20526341_ChIP-Seq_ESCs_Human0.92590108
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.91563726
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88552086
90BCL6_27268052_Chip-Seq_Bcells_Human0.88092135
91P300_19829295_ChIP-Seq_ESCs_Human0.87653861
92E2F1_20622854_ChIP-Seq_HELA_Human0.86421948
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86321816
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86190653
95HTT_18923047_ChIP-ChIP_STHdh_Human0.85055091
96P300_27268052_Chip-Seq_Bcells_Human0.84226289
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.84096905
98CBP_20019798_ChIP-Seq_JUKART_Human0.84011126
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84011126
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83642755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.39057297
2MP0006292_abnormal_olfactory_placode5.51946755
3MP0008789_abnormal_olfactory_epithelium2.95207584
4MP0003646_muscle_fatigue2.85443564
5MP0002163_abnormal_gland_morphology2.62705185
6MP0002102_abnormal_ear_morphology2.40061830
7MP0005394_taste/olfaction_phenotype2.26719336
8MP0005499_abnormal_olfactory_system2.26719336
9MP0008877_abnormal_DNA_methylation2.16963625
10MP0002837_dystrophic_cardiac_calcinosis2.15459151
11MP0001968_abnormal_touch/_nociception2.06070506
12MP0004142_abnormal_muscle_tone1.99375170
13MP0003787_abnormal_imprinting1.91846458
14MP0006276_abnormal_autonomic_nervous1.84465092
15MP0003011_delayed_dark_adaptation1.78062144
16MP0006072_abnormal_retinal_apoptosis1.63362858
17MP0003122_maternal_imprinting1.62071744
18MP0005379_endocrine/exocrine_gland_phen1.57513257
19MP0005671_abnormal_response_to1.55967103
20MP0004885_abnormal_endolymph1.54581149
21MP0001293_anophthalmia1.53922568
22MP0002909_abnormal_adrenal_gland1.53399326
23MP0005551_abnormal_eye_electrophysiolog1.51442193
24MP0005377_hearing/vestibular/ear_phenot1.50353404
25MP0003878_abnormal_ear_physiology1.50353404
26MP0003136_yellow_coat_color1.48307309
27MP0005646_abnormal_pituitary_gland1.48288192
28MP0005645_abnormal_hypothalamus_physiol1.44728856
29MP0008872_abnormal_physiological_respon1.44124659
30MP0004147_increased_porphyrin_level1.43936313
31MP0002876_abnormal_thyroid_physiology1.39199622
32MP0000631_abnormal_neuroendocrine_gland1.37973569
33MP0009046_muscle_twitch1.37880442
34MP0008875_abnormal_xenobiotic_pharmacok1.36183810
35MP0002160_abnormal_reproductive_system1.35664208
36MP0001986_abnormal_taste_sensitivity1.35203554
37MP0000049_abnormal_middle_ear1.34706418
38MP0001485_abnormal_pinna_reflex1.32978568
39MP0002938_white_spotting1.32225061
40MP0002095_abnormal_skin_pigmentation1.31830528
41MP0005389_reproductive_system_phenotype1.31644775
42MP0001905_abnormal_dopamine_level1.31239267
43MP0002138_abnormal_hepatobiliary_system1.26953161
44MP0002736_abnormal_nociception_after1.26412171
45MP0003121_genomic_imprinting1.23964142
46MP0001529_abnormal_vocalization1.23304155
47MP0002277_abnormal_respiratory_mucosa1.22814657
48MP0003123_paternal_imprinting1.20602617
49MP0009745_abnormal_behavioral_response1.19986094
50MP0010386_abnormal_urinary_bladder1.18135672
51MP0009333_abnormal_splenocyte_physiolog1.13717236
52MP0008775_abnormal_heart_ventricle1.13571713
53MP0002638_abnormal_pupillary_reflex1.12103496
54MP0003879_abnormal_hair_cell1.11143949
55MP0001919_abnormal_reproductive_system1.06568777
56MP0000372_irregular_coat_pigmentation1.05156562
57MP0008995_early_reproductive_senescence1.04232845
58MP0002272_abnormal_nervous_system1.03828959
59MP0003880_abnormal_central_pattern1.01756812
60MP0004742_abnormal_vestibular_system1.00460675
61MP0005253_abnormal_eye_physiology0.98581603
62MP0005174_abnormal_tail_pigmentation0.98390035
63MP0000026_abnormal_inner_ear0.97803489
64MP0002233_abnormal_nose_morphology0.94972067
65MP0003186_abnormal_redox_activity0.94885005
66MP0003195_calcinosis0.92898482
67MP0002557_abnormal_social/conspecific_i0.92175377
68MP0003806_abnormal_nucleotide_metabolis0.91867957
69MP0001963_abnormal_hearing_physiology0.89365121
70MP0000230_abnormal_systemic_arterial0.86812816
71MP0006036_abnormal_mitochondrial_physio0.86066667
72MP0001440_abnormal_grooming_behavior0.85835448
73MP0001324_abnormal_eye_pigmentation0.85811267
74MP0002653_abnormal_ependyma_morphology0.84744279
75MP0002210_abnormal_sex_determination0.84110575
76MP0005195_abnormal_posterior_eye0.81714380
77MP0003283_abnormal_digestive_organ0.81367944
78MP0003938_abnormal_ear_development0.80950816
79MP0004145_abnormal_muscle_electrophysio0.80845808
80MP0001486_abnormal_startle_reflex0.80816664
81MP0002733_abnormal_thermal_nociception0.80007647
82MP0002234_abnormal_pharynx_morphology0.77199114
83MP0001970_abnormal_pain_threshold0.76668298
84MP0001800_abnormal_humoral_immune0.76407998
85MP0003567_abnormal_fetal_cardiomyocyte0.75268519
86MP0003786_premature_aging0.75052388
87MP0003693_abnormal_embryo_hatching0.74876987
88MP0002752_abnormal_somatic_nervous0.69892761
89MP0001929_abnormal_gametogenesis0.68042141
90MP0000778_abnormal_nervous_system0.67897774
91MP0001835_abnormal_antigen_presentation0.66367765
92MP0001765_abnormal_ion_homeostasis0.65427097
93MP0003937_abnormal_limbs/digits/tail_de0.65289284
94MP0001501_abnormal_sleep_pattern0.62760573
95MP0002184_abnormal_innervation0.61711268
96MP0000653_abnormal_sex_gland0.60074747
97MP0003638_abnormal_response/metabolism_0.59647526
98MP0005391_vision/eye_phenotype0.59572947
99MP0010030_abnormal_orbit_morphology0.59437265
100MP0004924_abnormal_behavior0.58982346

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.31624815
2Abnormality of cells of the erythroid lineage (HP:0012130)5.10556649
3Acute necrotizing encephalopathy (HP:0006965)4.52888368
4Macrocytic anemia (HP:0001972)4.38786332
5Abnormal number of erythroid precursors (HP:0012131)4.38619530
6Abnormal mitochondria in muscle tissue (HP:0008316)3.95762519
7Acute encephalopathy (HP:0006846)3.92393805
8Mitochondrial inheritance (HP:0001427)3.88818153
9Lipid accumulation in hepatocytes (HP:0006561)3.74063192
10Progressive macrocephaly (HP:0004481)3.72303608
11Increased hepatocellular lipid droplets (HP:0006565)3.67493064
12Pallor (HP:0000980)3.66693092
133-Methylglutaconic aciduria (HP:0003535)3.66343979
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.57079959
15Increased intramyocellular lipid droplets (HP:0012240)3.40618483
16Increased CSF lactate (HP:0002490)3.39101187
17Congenital stationary night blindness (HP:0007642)3.27086449
18Renal Fanconi syndrome (HP:0001994)3.24962330
19Increased muscle lipid content (HP:0009058)3.21333200
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19210774
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19210774
22Abnormality of midbrain morphology (HP:0002418)3.16090873
23Molar tooth sign on MRI (HP:0002419)3.16090873
24Pancreatic cysts (HP:0001737)3.04696822
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96689865
26Abnormal rod and cone electroretinograms (HP:0008323)2.86247269
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78378103
28Absent thumb (HP:0009777)2.77266401
29Cerebral edema (HP:0002181)2.74820503
30Septo-optic dysplasia (HP:0100842)2.71696993
31Abnormal ciliary motility (HP:0012262)2.66234689
32Pendular nystagmus (HP:0012043)2.62567526
33Nephronophthisis (HP:0000090)2.58150806
34Pancreatic fibrosis (HP:0100732)2.57757551
35Hepatocellular necrosis (HP:0001404)2.55150897
36Colon cancer (HP:0003003)2.54606091
37Exertional dyspnea (HP:0002875)2.48751157
38Abnormal respiratory motile cilium physiology (HP:0012261)2.42056208
39Exercise intolerance (HP:0003546)2.40358195
40Maternal diabetes (HP:0009800)2.40267565
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40015245
42Hypoplasia of the fovea (HP:0007750)2.39559501
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.39559501
44True hermaphroditism (HP:0010459)2.38939712
45Abnormal respiratory epithelium morphology (HP:0012253)2.36037760
46Abnormal respiratory motile cilium morphology (HP:0005938)2.36037760
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.35918846
48Asplenia (HP:0001746)2.33833896
49Congenital, generalized hypertrichosis (HP:0004540)2.32633974
50Concave nail (HP:0001598)2.32219905
51Abnormality of renal resorption (HP:0011038)2.32145806
52Medial flaring of the eyebrow (HP:0010747)2.30051394
53Lactic acidosis (HP:0003128)2.28246373
54Hepatic necrosis (HP:0002605)2.23248780
55Hyperglycinemia (HP:0002154)2.22915273
56Abnormal hemoglobin (HP:0011902)2.19516115
57Increased serum lactate (HP:0002151)2.19163372
58Tubular atrophy (HP:0000092)2.15475040
59Stenosis of the external auditory canal (HP:0000402)2.15402364
60Optic disc pallor (HP:0000543)2.14698508
61Severe visual impairment (HP:0001141)2.09815868
62Respiratory difficulties (HP:0002880)2.08654893
63Abnormality of the renal cortex (HP:0011035)2.08550303
64Abnormality of the renal medulla (HP:0100957)2.07883189
65Rib fusion (HP:0000902)2.04383328
66Sclerocornea (HP:0000647)2.02741162
67Anencephaly (HP:0002323)2.01942681
68Glycosuria (HP:0003076)2.00783475
69Abnormality of urine glucose concentration (HP:0011016)2.00783475
70Respiratory failure (HP:0002878)2.00618898
71Abnormal drinking behavior (HP:0030082)1.99555222
72Polydipsia (HP:0001959)1.99555222
73Optic nerve hypoplasia (HP:0000609)1.96491351
74Depressed nasal ridge (HP:0000457)1.93948110
75Hyperthyroidism (HP:0000836)1.92687523
76Stomatitis (HP:0010280)1.91073217
77Abnormality of the fovea (HP:0000493)1.88372617
78Leukodystrophy (HP:0002415)1.88177075
79Chronic hepatic failure (HP:0100626)1.88109225
80Lethargy (HP:0001254)1.86834611
81Myokymia (HP:0002411)1.86270163
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.84737094
83Microretrognathia (HP:0000308)1.83950970
84Type II lissencephaly (HP:0007260)1.82981178
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82655621
86Anophthalmia (HP:0000528)1.82504361
87Chronic sinusitis (HP:0011109)1.82468751
88Abolished electroretinogram (ERG) (HP:0000550)1.79126915
89Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78566716
90Hypoplasia of the ulna (HP:0003022)1.76549853
91Hypoplasia of the radius (HP:0002984)1.76449242
92Abnormality of macular pigmentation (HP:0008002)1.74135927
93Abnormal pupillary function (HP:0007686)1.73422064
94Abnormality of DNA repair (HP:0003254)1.73185059
95IgG deficiency (HP:0004315)1.73100312
96Rhinitis (HP:0012384)1.72566209
97Gait imbalance (HP:0002141)1.71806541
98Triphalangeal thumb (HP:0001199)1.71338841
99Median cleft lip (HP:0000161)1.70182811
100Congenital primary aphakia (HP:0007707)1.69473626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.53440093
2STK163.24998974
3WNK42.77570046
4GRK12.66026927
5FRK2.58864932
6TAOK32.57365515
7STK392.53898446
8DYRK22.46773782
9MAP4K22.45888764
10TLK12.29168569
11MAP2K22.21173411
12ZAK2.18689999
13BCKDK1.97270319
14NME21.93605865
15CDK191.88174245
16PIK3CA1.76317680
17NUAK11.69912625
18CDC71.68437298
19LRRK21.60759654
20TXK1.45962107
21PINK11.44329737
22TIE11.41283482
23MST41.39330796
24OXSR11.32119123
25ABL21.32104049
26MUSK1.30244822
27TEC1.23339013
28MAP3K111.16331497
29MAPK131.13284557
30ADRBK11.12555433
31DYRK1A1.09919526
32LIMK10.99066693
33BMPR1B0.97630038
34PAK30.97101825
35INSRR0.96645587
36WNK30.94817023
37MAP4K10.94471989
38MKNK20.93721746
39RPS6KA50.93670719
40IKBKB0.91165783
41NTRK30.89398404
42TNIK0.87736005
43MAP3K40.85972127
44TNK20.84867103
45CDK80.84253993
46DYRK30.83697149
47CSNK2A20.83161127
48PDK20.81411376
49PRKCG0.79353016
50CAMK10.77955614
51EPHA40.77617491
52STK38L0.76407821
53PRKCQ0.74563827
54PRKACA0.72227556
55MAP2K10.71973511
56AURKB0.69414149
57PRKCI0.69102869
58MAP2K60.68675888
59CAMKK20.63819500
60CSNK2A10.62609328
61PHKG10.60202926
62PHKG20.60202926
63DAPK30.59822877
64OBSCN0.59695878
65ITK0.58805071
66LYN0.58730022
67SYK0.58212488
68GRK60.58130414
69DAPK20.57032027
70ERBB20.53838766
71PLK40.53567124
72IKBKE0.52137062
73PIM10.51998062
74CASK0.51152038
75STK110.50516060
76GRK50.49849179
77ATR0.49512618
78CDC42BPA0.49335275
79SRPK10.48460638
80EPHB20.47621147
81BTK0.47563650
82CSNK1E0.47349334
83MARK30.47254814
84CSNK1A10.45917056
85PLK10.45448144
86PRKCA0.45324488
87ABL10.45081998
88PRKD20.44388298
89AURKA0.43520756
90RPS6KA60.43332561
91CHEK20.41662740
92NEK10.40653846
93KIT0.40207978
94FES0.40199624
95PRKCZ0.38343797
96NTRK20.37970794
97CLK10.37686349
98VRK10.36756429
99SGK10.35892755
100CAMK2A0.34549697

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.04699023
2Oxidative phosphorylation_Homo sapiens_hsa001904.13131686
3Parkinsons disease_Homo sapiens_hsa050123.50903201
4Asthma_Homo sapiens_hsa053102.59140471
5Huntingtons disease_Homo sapiens_hsa050162.48955462
6Alzheimers disease_Homo sapiens_hsa050102.43161657
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37644489
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29552361
9Cardiac muscle contraction_Homo sapiens_hsa042602.27747212
10RNA polymerase_Homo sapiens_hsa030202.26168273
11Sulfur relay system_Homo sapiens_hsa041222.20460180
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.04062633
13Linoleic acid metabolism_Homo sapiens_hsa005911.97478424
14Allograft rejection_Homo sapiens_hsa053301.92062930
15Homologous recombination_Homo sapiens_hsa034401.91414925
16Autoimmune thyroid disease_Homo sapiens_hsa053201.82157087
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67740249
18Phototransduction_Homo sapiens_hsa047441.64584955
19Protein export_Homo sapiens_hsa030601.62411003
20Proteasome_Homo sapiens_hsa030501.62140832
21Graft-versus-host disease_Homo sapiens_hsa053321.47390075
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46249962
23Type I diabetes mellitus_Homo sapiens_hsa049401.42278889
24Primary immunodeficiency_Homo sapiens_hsa053401.39987542
25One carbon pool by folate_Homo sapiens_hsa006701.30823843
26Fanconi anemia pathway_Homo sapiens_hsa034601.29372333
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20814527
28Pyrimidine metabolism_Homo sapiens_hsa002401.17982064
29RNA degradation_Homo sapiens_hsa030181.17531288
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07677182
31DNA replication_Homo sapiens_hsa030301.07007217
32Olfactory transduction_Homo sapiens_hsa047401.03798952
33Arachidonic acid metabolism_Homo sapiens_hsa005901.02968678
34Basal transcription factors_Homo sapiens_hsa030221.00125183
35Chemical carcinogenesis_Homo sapiens_hsa052041.00088008
36Nicotine addiction_Homo sapiens_hsa050330.99303751
37Nitrogen metabolism_Homo sapiens_hsa009100.97429483
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97265331
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96964268
40Mismatch repair_Homo sapiens_hsa034300.96823363
41Caffeine metabolism_Homo sapiens_hsa002320.93355865
42Fat digestion and absorption_Homo sapiens_hsa049750.90384024
43Butanoate metabolism_Homo sapiens_hsa006500.89943599
44Tryptophan metabolism_Homo sapiens_hsa003800.88040921
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87504258
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85862486
47Ether lipid metabolism_Homo sapiens_hsa005650.84720460
48Nucleotide excision repair_Homo sapiens_hsa034200.84633843
49Purine metabolism_Homo sapiens_hsa002300.83332776
50Vitamin B6 metabolism_Homo sapiens_hsa007500.82023755
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80862018
52Spliceosome_Homo sapiens_hsa030400.80372299
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80249763
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80177817
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.79626055
56Rheumatoid arthritis_Homo sapiens_hsa053230.75490071
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73311815
58Retinol metabolism_Homo sapiens_hsa008300.72524933
59Morphine addiction_Homo sapiens_hsa050320.71618194
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.68554898
61Metabolic pathways_Homo sapiens_hsa011000.67190782
62Peroxisome_Homo sapiens_hsa041460.64144394
63Antigen processing and presentation_Homo sapiens_hsa046120.60676263
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59947844
65Propanoate metabolism_Homo sapiens_hsa006400.59819596
66Folate biosynthesis_Homo sapiens_hsa007900.59742933
67Regulation of autophagy_Homo sapiens_hsa041400.59733587
68Glutathione metabolism_Homo sapiens_hsa004800.57158574
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.56331817
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55736537
71Base excision repair_Homo sapiens_hsa034100.55663601
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54759559
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52493090
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.52111543
75Systemic lupus erythematosus_Homo sapiens_hsa053220.49734943
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49110044
77RNA transport_Homo sapiens_hsa030130.48610245
78Selenocompound metabolism_Homo sapiens_hsa004500.44504850
79beta-Alanine metabolism_Homo sapiens_hsa004100.41928128
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41406234
81Hematopoietic cell lineage_Homo sapiens_hsa046400.37537684
82Collecting duct acid secretion_Homo sapiens_hsa049660.37112808
83Viral myocarditis_Homo sapiens_hsa054160.34877183
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34572549
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34467674
86Staphylococcus aureus infection_Homo sapiens_hsa051500.32591488
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32420921
88Tyrosine metabolism_Homo sapiens_hsa003500.30826808
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.29620633
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29396467
91Serotonergic synapse_Homo sapiens_hsa047260.29338873
92Insulin secretion_Homo sapiens_hsa049110.28963932
93Ovarian steroidogenesis_Homo sapiens_hsa049130.27975897
94GABAergic synapse_Homo sapiens_hsa047270.25224273
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25098656
96Taste transduction_Homo sapiens_hsa047420.21802644
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21440856
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.19864146
99Sulfur metabolism_Homo sapiens_hsa009200.18384551
100p53 signaling pathway_Homo sapiens_hsa041150.16155203

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