ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	9.86039389
2	ribosomal small subunit biogenesis (GO:0042274)	9.22081361
3	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	8.80084389
4	UMP biosynthetic process (GO:0006222)	8.80084389
5	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	8.80084389
6	UMP metabolic process (GO:0046049)	8.80084389
7	viral transcription (GO:0019083)	8.10193719
8	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	8.09071812
9	translational termination (GO:0006415)	7.85711499
10	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	7.67247054
11	translational elongation (GO:0006414)	7.07801204
12	ncRNA 3-end processing (GO:0043628)	6.97841231
13	CTP metabolic process (GO:0046036)	6.67415012
14	CTP biosynthetic process (GO:0006241)	6.67415012
15	ribosomal small subunit assembly (GO:0000028)	6.55554350
16	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	6.18791388
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.18637014
18	cellular protein complex disassembly (GO:0043624)	6.07972226
19	cotranslational protein targeting to membrane (GO:0006613)	6.03624492
20	protein targeting to ER (GO:0045047)	5.96495450
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.79462188
22	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	5.73223682
23	viral life cycle (GO:0019058)	5.68199751
24	diterpenoid biosynthetic process (GO:0016102)	5.60154423
25	protein localization to endoplasmic reticulum (GO:0070972)	5.56089503
26	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	5.53202254
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.47234657
28	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	5.21716414
29	protein complex disassembly (GO:0043241)	5.16840087
30	pentose-phosphate shunt (GO:0006098)	5.09819342
31	pentose metabolic process (GO:0019321)	5.00024252
32	terpenoid biosynthetic process (GO:0016114)	4.82376013
33	purine nucleotide salvage (GO:0032261)	4.81844547
34	cellular metabolic compound salvage (GO:0043094)	4.78453264
35	translational initiation (GO:0006413)	4.76124090
36	DNA synthesis involved in DNA repair (GO:0000731)	4.75830301
37	macromolecular complex disassembly (GO:0032984)	4.74690030
38	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	4.68403154
39	NADPH regeneration (GO:0006740)	4.55005984
40	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	4.47280244
41	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.43893942
42	keratinocyte development (GO:0003334)	4.39983639
43	ribosomal large subunit biogenesis (GO:0042273)	4.27426969
44	pyrimidine nucleoside biosynthetic process (GO:0046134)	4.22530317
45	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.20403401
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.20403401
47	regulation of activation of Janus kinase activity (GO:0010533)	4.14069370
48	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.98158526
49	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.94885118
50	protein targeting to membrane (GO:0006612)	3.93947568
51	maturation of SSU-rRNA (GO:0030490)	3.92797452
52	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.90862302
53	translation (GO:0006412)	3.84388219
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.79084578
55	glucose catabolic process (GO:0006007)	3.72138476
56	purine-containing compound salvage (GO:0043101)	3.64909276
57	phosphatidylglycerol biosynthetic process (GO:0006655)	3.59127292
58	regulation of glycogen (starch) synthase activity (GO:2000465)	3.58924483
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58041320
60	pyrimidine-containing compound biosynthetic process (GO:0072528)	3.56748783
61	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.55987632
62	response to folic acid (GO:0051593)	3.55073980
63	NADH metabolic process (GO:0006734)	3.52452605
64	cardiolipin metabolic process (GO:0032048)	3.44718182
65	pyrimidine nucleotide metabolic process (GO:0006220)	3.40845770
66	negative regulation of JAK-STAT cascade (GO:0046426)	3.39246923
67	peptidyl-cysteine modification (GO:0018198)	3.38685616
68	cellular component biogenesis (GO:0044085)	3.35571734
69	mRNA catabolic process (GO:0006402)	3.33261241
70	negative regulation of keratinocyte proliferation (GO:0010839)	3.31678168
71	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30549751
72	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.28857249
73	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.21845688
74	protein complex biogenesis (GO:0070271)	3.14968812
75	grooming behavior (GO:0007625)	3.08382850
76	neutrophil mediated immunity (GO:0002446)	3.08297420
77	regulation of energy homeostasis (GO:2000505)	2.96689297
78	RNA catabolic process (GO:0006401)	2.95781494
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.84549734
80	positive regulation of NIK/NF-kappaB signaling (GO:1901224)	2.82955150
81	tRNA modification (GO:0006400)	2.81975485
82	ATP synthesis coupled proton transport (GO:0015986)	2.79201680
83	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.79201680
84	positive regulation of epidermal cell differentiation (GO:0045606)	2.74492906
85	nucleoside triphosphate biosynthetic process (GO:0009142)	2.73997750
86	pyrimidine nucleoside metabolic process (GO:0006213)	2.72736307
87	catecholamine transport (GO:0051937)	2.70178583
88	peptidyl-lysine dimethylation (GO:0018027)	2.69352328
89	negative regulation of B cell apoptotic process (GO:0002903)	2.69112165
90	S-adenosylmethionine metabolic process (GO:0046500)	2.67191867
91	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.65772634
92	nucleoside monophosphate biosynthetic process (GO:0009124)	2.64499953
93	establishment of protein localization to membrane (GO:0090150)	2.64360649
94	purine nucleobase biosynthetic process (GO:0009113)	2.60274773
95	retinal metabolic process (GO:0042574)	2.58590285
96	centrosome duplication (GO:0051298)	2.57528031
97	NADH dehydrogenase complex assembly (GO:0010257)	2.55742173
98	pyrimidine nucleoside salvage (GO:0043097)	11.7425921
99	pyrimidine-containing compound salvage (GO:0008655)	11.7425921
100	nucleoside salvage (GO:0043174)	10.4901336

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	9.16645525
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85656789
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.82516743
4	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	2.78384400
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.58037843
6	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.39147388
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35034732
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34947616
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.32883399
10	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.24595507
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.18978173
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.16643228
13	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.12027561
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.09807043
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88977990
16	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.82365965
17	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.79278501
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72896859
19	EGR1_19032775_ChIP-ChIP_M12_Human	1.69524644
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67400414
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.65529572
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63205977
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.58729208
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.58163703
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.57612456
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.56439582
27	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.52537853
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.48620048
29	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.47988329
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.47988329
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47358587
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.44522500
33	ERA_21632823_ChIP-Seq_H3396_Human	1.44284427
34	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.43788768
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43583748
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.43232805
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.42070593
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36627782
39	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.36434928
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35687242
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.35515667
42	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.35107981
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35096623
44	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.34888555
45	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.34888555
46	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.34888555
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34565832
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.32978416
49	NCOR_22424771_ChIP-Seq_293T_Human	1.31654046
50	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30460483
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30319686
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29119558
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28547047
54	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25510422
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.22204646
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.20756026
57	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.20419892
58	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.17057970
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17012655
60	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16322050
61	SA1_27219007_Chip-Seq_Bcells_Human	1.16048819
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15027519
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13319187
64	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13213177
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.10941827
66	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08976123
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.08406934
68	FUS_26573619_Chip-Seq_HEK293_Human	1.07332048
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07219737
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06432496
71	E2F1_20622854_ChIP-Seq_HELA_Human	1.06258221
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03052379
73	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.02076436
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.02052020
75	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.00939734
76	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00902010
77	BCOR_27268052_Chip-Seq_Bcells_Human	1.00500413
78	P68_20966046_ChIP-Seq_HELA_Human	1.00102545
79	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98681943
80	EWS_26573619_Chip-Seq_HEK293_Human	0.96273552
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96188204
82	VDR_23849224_ChIP-Seq_CD4+_Human	0.94418494
83	BCAT_22108803_ChIP-Seq_LS180_Human	0.94267708
84	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93926240
85	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93895608
86	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.93861021
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93278135
88	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92488274
89	CTCF_27219007_Chip-Seq_Bcells_Human	0.92082451
90	PHF8_20622853_ChIP-Seq_HELA_Human	0.90622093
91	VDR_21846776_ChIP-Seq_THP-1_Human	0.90552258
92	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90310540
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89906033
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89210868
95	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.89074676
96	TTF2_22483619_ChIP-Seq_HELA_Human	0.88274153
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88261176
98	MYC_18940864_ChIP-ChIP_HL60_Human	0.88040639
99	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.87605362
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.86873906

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006082_CNS_inflammation	5.31470273
2	MP0001873_stomach_inflammation	5.28086119
3	MP0004510_myositis	4.85592147
4	MP0002163_abnormal_gland_morphology	4.36314937
5	MP0006292_abnormal_olfactory_placode	3.62255919
6	MP0003646_muscle_fatigue	3.60609997
7	MP0008875_abnormal_xenobiotic_pharmacok	3.44213118
8	MP0003879_abnormal_hair_cell	3.19482022
9	MP0001348_abnormal_lacrimal_gland	3.12981428
10	MP0005379_endocrine/exocrine_gland_phen	2.98146641
11	MP0004145_abnormal_muscle_electrophysio	2.44103345
12	MP0002933_joint_inflammation	2.34132610
13	MP0001727_abnormal_embryo_implantation	2.18883469
14	MP0003724_increased_susceptibility_to	1.91620224
15	MP0002234_abnormal_pharynx_morphology	1.90650579
16	MP0003121_genomic_imprinting	1.89422391
17	MP0009379_abnormal_foot_pigmentation	1.86063626
18	MP0001663_abnormal_digestive_system	1.77787175
19	MP0005646_abnormal_pituitary_gland	1.77651498
20	MP0000538_abnormal_urinary_bladder	1.61259878
21	MP0005377_hearing/vestibular/ear_phenot	1.59802718
22	MP0003878_abnormal_ear_physiology	1.59802718
23	MP0008872_abnormal_physiological_respon	1.54872552
24	MP0003195_calcinosis	1.45077924
25	MP0001346_abnormal_lacrimal_gland	1.43184190
26	MP0005360_urolithiasis	1.36229557
27	MP0002095_abnormal_skin_pigmentation	1.33752137
28	MP0009333_abnormal_splenocyte_physiolog	1.33279600
29	MP0003806_abnormal_nucleotide_metabolis	1.31006323
30	MP0005381_digestive/alimentary_phenotyp	1.30873670
31	MP0001986_abnormal_taste_sensitivity	1.29317666
32	MP0000015_abnormal_ear_pigmentation	1.27890465
33	MP0005075_abnormal_melanosome_morpholog	1.27726395
34	MP0000372_irregular_coat_pigmentation	1.25857053
35	MP0002837_dystrophic_cardiac_calcinosis	1.24772497
36	MP0002249_abnormal_larynx_morphology	1.16590179
37	MP0009785_altered_susceptibility_to	1.16192844
38	MP0005671_abnormal_response_to	1.04992178
39	MP0001800_abnormal_humoral_immune	1.02941152
40	MP0005310_abnormal_salivary_gland	1.02885148
41	MP0003136_yellow_coat_color	1.02442970
42	MP0006276_abnormal_autonomic_nervous	1.01475504
43	MP0000579_abnormal_nail_morphology	1.01099122
44	MP0005000_abnormal_immune_tolerance	1.00897877
45	MP0002277_abnormal_respiratory_mucosa	0.99597884
46	MP0004885_abnormal_endolymph	0.98179042
47	MP0001905_abnormal_dopamine_level	0.93993771
48	MP0002736_abnormal_nociception_after	0.93688315
49	MP0000703_abnormal_thymus_morphology	0.93070743
50	MP0001835_abnormal_antigen_presentation	0.91388658
51	MP0000049_abnormal_middle_ear	0.88885718
52	MP0001968_abnormal_touch/_nociception	0.88726364
53	MP0005503_abnormal_tendon_morphology	0.86421398
54	MP0001919_abnormal_reproductive_system	0.84722048
55	MP0002132_abnormal_respiratory_system	0.82507622
56	MP0001664_abnormal_digestion	0.82172459
57	MP0000678_abnormal_parathyroid_gland	0.81864345
58	MP0005389_reproductive_system_phenotype	0.80086771
59	MP0009765_abnormal_xenobiotic_induced	0.78757281
60	MP0008877_abnormal_DNA_methylation	0.77474355
61	MP0003943_abnormal_hepatobiliary_system	0.76851355
62	MP0002102_abnormal_ear_morphology	0.76487467
63	MP0009780_abnormal_chondrocyte_physiolo	0.76208573
64	MP0004142_abnormal_muscle_tone	0.73707013
65	MP0000689_abnormal_spleen_morphology	0.73410623
66	MP0002160_abnormal_reproductive_system	0.72417047
67	MP0000383_abnormal_hair_follicle	0.71929719
68	MP0000631_abnormal_neuroendocrine_gland	0.71758216
69	MP0010329_abnormal_lipoprotein_level	0.71716462
70	MP0004858_abnormal_nervous_system	0.71321011
71	MP0001756_abnormal_urination	0.70958581
72	MP0001790_abnormal_immune_system	0.69765645
73	MP0005387_immune_system_phenotype	0.69765645
74	MP0009745_abnormal_behavioral_response	0.68638732
75	MP0001879_abnormal_lymphatic_vessel	0.68345632
76	MP0000470_abnormal_stomach_morphology	0.67973312
77	MP0002116_abnormal_craniofacial_bone	0.66837029
78	MP0004036_abnormal_muscle_relaxation	0.66002647
79	MP0005551_abnormal_eye_electrophysiolog	0.65462076
80	MP0002723_abnormal_immune_serum	0.65364725
81	MP0001270_distended_abdomen	0.64513804
82	MP0003011_delayed_dark_adaptation	0.63072972
83	MP0002722_abnormal_immune_system	0.62969573
84	MP0005197_abnormal_uvea_morphology	0.61684074
85	MP0002108_abnormal_muscle_morphology	0.61522511
86	MP0002405_respiratory_system_inflammati	0.61331730
87	MP0004147_increased_porphyrin_level	0.60562504
88	MP0003763_abnormal_thymus_physiology	0.60273527
89	MP0009250_abnormal_appendicular_skeleto	0.59571822
90	MP0001853_heart_inflammation	0.58565520
91	MP0001944_abnormal_pancreas_morphology	0.58151841
92	MP0008995_early_reproductive_senescence	0.56813169
93	MP0002932_abnormal_joint_morphology	0.56714606
94	MP0002398_abnormal_bone_marrow	0.55874015
95	MP0003123_paternal_imprinting	0.55798737
96	MP0008873_increased_physiological_sensi	0.55690551
97	MP0010155_abnormal_intestine_physiology	0.55482504
98	MP0005167_abnormal_blood-brain_barrier	0.54903284
99	MP0002452_abnormal_antigen_presenting	0.54896378
100	MP0002420_abnormal_adaptive_immunity	0.54486690

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Metaphyseal cupping (HP:0003021)	5.65930474
2	Difficulty running (HP:0009046)	5.63852171
3	Abnormality of macular pigmentation (HP:0008002)	5.45092273
4	Hip dysplasia (HP:0001385)	5.07132289
5	Constricted visual fields (HP:0001133)	5.03756615
6	Round ear (HP:0100830)	4.69800010
7	Hip contracture (HP:0003273)	4.67874585
8	Striae distensae (HP:0001065)	4.48329722
9	Cupped ribs (HP:0000887)	4.44308044
10	Achilles tendon contracture (HP:0001771)	4.32735292
11	Volvulus (HP:0002580)	4.20474325
12	Toxemia of pregnancy (HP:0100603)	3.96966657
13	Abnormality of the Achilles tendon (HP:0005109)	3.93356522
14	Hypoplasia of the pons (HP:0012110)	3.82371880
15	Acute necrotizing encephalopathy (HP:0006965)	3.81632729
16	Cone-rod dystrophy (HP:0000548)	3.65073060
17	Increased hepatocellular lipid droplets (HP:0006565)	3.56546721
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.54374962
19	Limited hip movement (HP:0008800)	3.51158120
20	Renal Fanconi syndrome (HP:0001994)	3.48550072
21	Abnormality of the pons (HP:0007361)	3.46799664
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.41214061
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.34422763
24	Attenuation of retinal blood vessels (HP:0007843)	3.32609230
25	Opisthotonus (HP:0002179)	3.30433645
26	Abnormal number of erythroid precursors (HP:0012131)	3.25363712
27	Progressive macrocephaly (HP:0004481)	3.22158303
28	Acute encephalopathy (HP:0006846)	3.15524110
29	Degeneration of anterior horn cells (HP:0002398)	3.15484230
30	Abnormality of the anterior horn cell (HP:0006802)	3.15484230
31	Poor suck (HP:0002033)	3.08319954
32	Mitochondrial inheritance (HP:0001427)	3.02600857
33	Asplenia (HP:0001746)	2.96707150
34	Brushfield spots (HP:0001088)	2.95768016
35	Dyskinesia (HP:0100660)	2.91341542
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.87211155
37	Hyperglycinemia (HP:0002154)	2.87091815
38	Lipid accumulation in hepatocytes (HP:0006561)	2.86713845
39	Increased intramyocellular lipid droplets (HP:0012240)	2.85517442
40	Optic disc pallor (HP:0000543)	2.84253502
41	Exertional dyspnea (HP:0002875)	2.80818314
42	Oligodontia (HP:0000677)	2.67392248
43	Large earlobe (HP:0009748)	2.63781198
44	Macrocytic anemia (HP:0001972)	2.62018599
45	Hyperthyroidism (HP:0000836)	2.56170767
46	Knee flexion contracture (HP:0006380)	2.55017884
47	Tibial bowing (HP:0002982)	2.53706433
48	Abnormal hemoglobin (HP:0011902)	2.52418877
49	Increased CSF lactate (HP:0002490)	2.51608263
50	Decreased muscle mass (HP:0003199)	2.51353922
51	Pallor (HP:0000980)	2.48303356
52	Congenital, generalized hypertrichosis (HP:0004540)	2.43048588
53	Female pseudohermaphroditism (HP:0010458)	2.41057598
54	Abnormality of the fingertips (HP:0001211)	2.38330419
55	Cerebral edema (HP:0002181)	2.36550190
56	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.32589867
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24946626
58	Abnormality of renal resorption (HP:0011038)	2.23781761
59	Increased muscle lipid content (HP:0009058)	2.19077883
60	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.18462500
61	Esophageal neoplasm (HP:0100751)	2.15821765
62	Neoplasm of head and neck (HP:0012288)	2.15821765
63	Progressive microcephaly (HP:0000253)	2.15791196
64	Impaired smooth pursuit (HP:0007772)	2.12222897
65	Respiratory difficulties (HP:0002880)	2.11787974
66	Concave nail (HP:0001598)	2.09824082
67	Ovoid vertebral bodies (HP:0003300)	2.09268412
68	3-Methylglutaconic aciduria (HP:0003535)	2.09034236
69	Waddling gait (HP:0002515)	2.08434519
70	Hyperphosphaturia (HP:0003109)	2.06924518
71	Gowers sign (HP:0003391)	2.06167827
72	Gonadal dysgenesis (HP:0000133)	2.04468295
73	Parakeratosis (HP:0001036)	2.04215538
74	Femoral bowing (HP:0002980)	2.03576092
75	Abnormal drinking behavior (HP:0030082)	2.02039026
76	Polydipsia (HP:0001959)	2.02039026
77	Posterior embryotoxon (HP:0000627)	1.96549822
78	Hematochezia (HP:0002573)	1.94501323
79	Lack of skin elasticity (HP:0100679)	1.94068331
80	Abnormality of the line of Schwalbe (HP:0008048)	1.93965214
81	Hypoplasia of the uterus (HP:0000013)	1.92448688
82	Pancreatic fibrosis (HP:0100732)	1.89531830
83	Small hand (HP:0200055)	1.88526719
84	Abnormality of magnesium homeostasis (HP:0004921)	1.86117161
85	Severe global developmental delay (HP:0011344)	1.85377271
86	Prominent supraorbital ridges (HP:0000336)	1.85068650
87	Recurrent otitis media (HP:0000403)	1.82559076
88	Primary adrenal insufficiency (HP:0008207)	1.79224499
89	Severe visual impairment (HP:0001141)	1.75862038
90	Congenital stationary night blindness (HP:0007642)	1.74160419
91	Fasciculations (HP:0002380)	1.73500014
92	Prenatal maternal abnormality (HP:0002686)	1.70587014
93	Hypomagnesemia (HP:0002917)	1.69880572
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.67535148
95	Abnormality of urine glucose concentration (HP:0011016)	1.67005077
96	Glycosuria (HP:0003076)	1.67005077
97	Broad nasal tip (HP:0000455)	1.66605470
98	Abnormal number of incisors (HP:0011064)	1.65179427
99	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.64383823
100	Limited elbow extension (HP:0001377)	1.63458913

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KIT	6.07445070
2	LIMK1	5.35079850
3	MAP4K1	3.88269153
4	TEC	3.08698499
5	FES	2.97271246
6	NME2	2.35796757
7	BMPR1B	2.34121190
8	BCKDK	2.28694669
9	TESK1	2.21263204
10	NLK	2.06228921
11	CSF1R	1.88461995
12	IKBKB	1.86541029
13	LRRK2	1.83720354
14	PDK2	1.80479642
15	ADRBK2	1.72975715
16	WNK4	1.68136404
17	SYK	1.55230579
18	GRK1	1.48592370
19	IKBKE	1.43902720
20	PRKCG	1.34021004
21	TGFBR1	1.29283317
22	ABL2	1.28255234
23	FRK	1.22220230
24	CSK	1.17614772
25	TYRO3	1.15176422
26	PKN1	1.14637871
27	TXK	1.12285202
28	CDK3	1.11575764
29	ADRBK1	1.10968085
30	SGK2	1.06653833
31	PRKCQ	1.05383856
32	RPS6KA5	1.05029370
33	KDR	1.03237685
34	SIK2	1.02629540
35	ACVR1B	1.00099821
36	LCK	0.97292099
37	LYN	0.96637053
38	MAP4K2	0.95537464
39	INSRR	0.93753884
40	PLK4	0.93457649
41	OBSCN	0.93424639
42	WNK3	0.89212883
43	CDK19	0.86891258
44	CDC42BPA	0.86255664
45	PIK3CA	0.84399424
46	CSNK2A2	0.84054596
47	JAK3	0.78969452
48	SGK494	0.78944499
49	SGK223	0.78944499
50	PDK1	0.75656536
51	CSNK2A1	0.74007407
52	INSR	0.73016845
53	MUSK	0.72847185
54	GRK7	0.72325520
55	DYRK1A	0.71657271
56	RPS6KB2	0.66196121
57	BTK	0.65955963
58	PRKCA	0.65403933
59	CDK4	0.64072558
60	CDK8	0.63782036
61	TIE1	0.62415785
62	PRKACA	0.62101759
63	EGFR	0.60310283
64	PAK1	0.58986745
65	CSNK1A1	0.56963837
66	DYRK3	0.56098769
67	STK39	0.52164015
68	EPHA4	0.50903418
69	ABL1	0.50085050
70	MINK1	0.49612412
71	PIK3CG	0.48768630
72	NTRK2	0.47980680
73	SGK3	0.46953746
74	DYRK2	0.45907743
75	ITK	0.45550882
76	RET	0.45494235
77	CSNK1G1	0.45304911
78	PLK2	0.44645187
79	TLK1	0.44286515
80	FYN	0.42180742
81	CHEK2	0.41974573
82	PRKCB	0.40296510
83	AURKA	0.39281615
84	FGR	0.38696165
85	PIM2	0.38403096
86	PIM1	0.37891293
87	IGF1R	0.37797563
88	RPS6KA6	0.37310142
89	CSNK1D	0.37099329
90	CDK2	0.37093298
91	PDPK1	0.34785020
92	SRC	0.34271997
93	OXSR1	0.34033548
94	PRKACG	0.33175914
95	CAMK2A	0.32548630
96	ZAK	0.32411550
97	TNK2	0.31424127
98	RPS6KA4	0.30781294
99	PLK1	0.30668511
100	STK16	0.30292464

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.45556821
2	Sulfur relay system_Homo sapiens_hsa04122	6.19465502
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46358978
4	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.86826923
5	Parkinsons disease_Homo sapiens_hsa05012	2.57121015
6	Pentose phosphate pathway_Homo sapiens_hsa00030	2.35577249
7	Pyrimidine metabolism_Homo sapiens_hsa00240	2.19096655
8	Asthma_Homo sapiens_hsa05310	2.10543742
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.03380228
10	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.00081747
11	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.89934584
12	Alzheimers disease_Homo sapiens_hsa05010	1.85377611
13	Huntingtons disease_Homo sapiens_hsa05016	1.83177878
14	Allograft rejection_Homo sapiens_hsa05330	1.71348689
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.71209888
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.66294642
17	Sulfur metabolism_Homo sapiens_hsa00920	1.62352661
18	Phototransduction_Homo sapiens_hsa04744	1.58186390
19	Fat digestion and absorption_Homo sapiens_hsa04975	1.52896401
20	DNA replication_Homo sapiens_hsa03030	1.49054591
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.43775160
22	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.40254694
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38255361
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.30598986
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30530973
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28281329
27	Measles_Homo sapiens_hsa05162	1.26317787
28	Glycerolipid metabolism_Homo sapiens_hsa00561	1.22988470
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14115535
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09704350
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05210468
32	Olfactory transduction_Homo sapiens_hsa04740	1.02964943
33	RNA polymerase_Homo sapiens_hsa03020	1.02764777
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97794598
35	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94871464
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.94107767
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93347296
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91980915
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.87526879
40	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84102501
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.81381646
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78395554
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78381632
44	Purine metabolism_Homo sapiens_hsa00230	0.78065792
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77979839
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77431933
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73476795
48	Malaria_Homo sapiens_hsa05144	0.73346593
49	Metabolic pathways_Homo sapiens_hsa01100	0.73257612
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.73240080
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72542889
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.72278618
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.72224396
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70964839
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69001030
56	Nicotine addiction_Homo sapiens_hsa05033	0.65624885
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65138265
58	One carbon pool by folate_Homo sapiens_hsa00670	0.64696156
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64202680
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60404148
61	Peroxisome_Homo sapiens_hsa04146	0.58981343
62	Butanoate metabolism_Homo sapiens_hsa00650	0.57655647
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55156731
64	Base excision repair_Homo sapiens_hsa03410	0.53471039
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52407281
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.51931599
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50468744
68	Retinol metabolism_Homo sapiens_hsa00830	0.49386017
69	Proteasome_Homo sapiens_hsa03050	0.48599042
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48281804
71	Mismatch repair_Homo sapiens_hsa03430	0.46578285
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46448867
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45237394
74	Carbon metabolism_Homo sapiens_hsa01200	0.42539249
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42284806
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40538772
77	RNA degradation_Homo sapiens_hsa03018	0.38717996
78	Caffeine metabolism_Homo sapiens_hsa00232	0.37525017
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37349050
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.33118942
81	Histidine metabolism_Homo sapiens_hsa00340	0.32235639
82	Viral myocarditis_Homo sapiens_hsa05416	0.32014811
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31994430
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30905864
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29347522
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.28310163
87	Alcoholism_Homo sapiens_hsa05034	0.27715131
88	Leishmaniasis_Homo sapiens_hsa05140	0.26891576
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25735332
90	Taste transduction_Homo sapiens_hsa04742	0.25148481
91	Homologous recombination_Homo sapiens_hsa03440	0.24247003
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22251244
93	Apoptosis_Homo sapiens_hsa04210	0.22204920
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20993101
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.20591842
96	Fanconi anemia pathway_Homo sapiens_hsa03460	0.18435212
97	Complement and coagulation cascades_Homo sapiens_hsa04610	0.17935159
98	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.16968063
99	Influenza A_Homo sapiens_hsa05164	0.16746349
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.16617985

RPS12P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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