RPS12P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside salvage (GO:0043174)9.92257908
2pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)9.11058576
3pyrimidine nucleoside monophosphate metabolic process (GO:0009129)8.51128643
4viral transcription (GO:0019083)8.04156765
5translational termination (GO:0006415)7.84715208
6CTP biosynthetic process (GO:0006241)6.87343128
7CTP metabolic process (GO:0046036)6.87343128
8translational elongation (GO:0006414)6.82106522
9pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)6.49880872
10ribosomal small subunit assembly (GO:0000028)6.39004609
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.28861489
12keratinocyte development (GO:0003334)6.28236080
13cotranslational protein targeting to membrane (GO:0006613)6.18959679
14protein targeting to ER (GO:0045047)6.13406583
15cellular protein complex disassembly (GO:0043624)6.08375559
16diterpenoid biosynthetic process (GO:0016102)6.06750363
17pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)6.02735361
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.86555981
19regulation of glycogen (starch) synthase activity (GO:2000465)5.72507115
20protein localization to endoplasmic reticulum (GO:0070972)5.70444558
21viral life cycle (GO:0019058)5.66962967
22pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)5.62668807
23pentose-phosphate shunt (GO:0006098)5.56829791
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.54704583
25pentose metabolic process (GO:0019321)5.52758889
26pyrimidine ribonucleoside biosynthetic process (GO:0046132)5.38523468
27protein complex disassembly (GO:0043241)5.24971297
28activation of NF-kappaB-inducing kinase activity (GO:0007250)5.14038304
29pyrimidine ribonucleotide biosynthetic process (GO:0009220)5.12684214
30regulation of activation of Janus kinase activity (GO:0010533)5.06020142
31pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.99614858
32purine nucleotide salvage (GO:0032261)4.97024001
33NADPH regeneration (GO:0006740)4.96155937
34terpenoid biosynthetic process (GO:0016114)4.94727994
35macromolecular complex disassembly (GO:0032984)4.91320754
36translational initiation (GO:0006413)4.84452640
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.77564647
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.77564647
39pyrimidine ribonucleotide metabolic process (GO:0009218)4.62298457
40cellular metabolic compound salvage (GO:0043094)4.49588051
41ribosomal small subunit biogenesis (GO:0042274)4.29701785
42pyrimidine nucleotide biosynthetic process (GO:0006221)4.11008148
43protein targeting to membrane (GO:0006612)4.09455968
44positive regulation of NIK/NF-kappaB signaling (GO:1901224)4.01524163
45maturation of SSU-rRNA (GO:0030490)3.96972169
46glucose catabolic process (GO:0006007)3.95724673
47pyrimidine nucleoside biosynthetic process (GO:0046134)3.92294110
48negative regulation of keratinocyte proliferation (GO:0010839)3.91380369
49pyrimidine ribonucleoside metabolic process (GO:0046131)3.89898781
50neutrophil mediated immunity (GO:0002446)3.86453460
51DNA ligation (GO:0006266)3.78456753
52translation (GO:0006412)3.76893954
53interleukin-6-mediated signaling pathway (GO:0070102)3.67618328
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61988194
55regulation of NIK/NF-kappaB signaling (GO:1901222)3.51691498
56negative regulation of JAK-STAT cascade (GO:0046426)3.51426856
57response to folic acid (GO:0051593)3.50909420
58regulation of hypersensitivity (GO:0002883)3.47199001
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.44809069
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.39180692
61peptidyl-lysine dimethylation (GO:0018027)3.28282027
62pyrimidine-containing compound biosynthetic process (GO:0072528)3.27250039
63peptidyl-cysteine modification (GO:0018198)3.24274343
64ribosomal large subunit biogenesis (GO:0042273)3.23680053
65mRNA catabolic process (GO:0006402)3.23373882
66negative regulation of B cell apoptotic process (GO:0002903)3.19570081
67response to nitric oxide (GO:0071731)3.16041882
68translesion synthesis (GO:0019985)3.14404546
69centrosome duplication (GO:0051298)3.09804141
70ribonucleoside triphosphate biosynthetic process (GO:0009201)3.07264203
71pyrimidine nucleotide metabolic process (GO:0006220)3.07061718
72myeloid leukocyte mediated immunity (GO:0002444)3.04475830
73monocyte chemotaxis (GO:0002548)2.98769848
74RNA catabolic process (GO:0006401)2.97917862
75neutrophil activation involved in immune response (GO:0002283)2.95533988
76catecholamine transport (GO:0051937)2.90784797
77mammary gland epithelial cell differentiation (GO:0060644)2.90186390
78negative regulation of interleukin-8 production (GO:0032717)2.90135618
79DNA synthesis involved in DNA repair (GO:0000731)2.85975281
80retinal metabolic process (GO:0042574)2.82494961
81positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81912838
82establishment of skin barrier (GO:0061436)2.76903926
83behavioral response to nicotine (GO:0035095)2.74257627
84positive regulation of epidermal cell differentiation (GO:0045606)2.73321920
85pyrimidine nucleoside metabolic process (GO:0006213)2.73145328
86regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.73077697
87negative regulation of stem cell proliferation (GO:2000647)2.69333642
88tRNA modification (GO:0006400)2.67831255
89establishment of protein localization to membrane (GO:0090150)2.66429021
90piRNA metabolic process (GO:0034587)2.65491707
91organ or tissue specific immune response (GO:0002251)2.60602257
92purine nucleobase biosynthetic process (GO:0009113)2.60114529
93mitochondrial respiratory chain complex assembly (GO:0033108)2.59534222
94nucleotide salvage (GO:0043173)11.0635499
95pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)10.8902341
96UMP biosynthetic process (GO:0006222)10.8902341
97pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)10.8902341
98UMP metabolic process (GO:0046049)10.8902341
99pyrimidine nucleoside salvage (GO:0043097)10.7923786
100pyrimidine-containing compound salvage (GO:0008655)10.7923786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.74385336
2EZH2_22144423_ChIP-Seq_EOC_Human4.44920422
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.45775754
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09146516
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75728734
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.57166827
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50432067
8RUNX_20019798_ChIP-Seq_JUKART_Human2.41454603
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.34023890
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.21411476
11POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.20560680
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09074115
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.08767807
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04733470
15POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89805545
16IRF1_19129219_ChIP-ChIP_H3396_Human1.88966583
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88854993
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87803118
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86138585
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81636443
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81636443
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81636443
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79084413
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.78202522
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.74132883
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71679748
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.71033756
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.67991105
29VDR_22108803_ChIP-Seq_LS180_Human1.65766792
30TP53_22573176_ChIP-Seq_HFKS_Human1.60681098
31ELK1_19687146_ChIP-ChIP_HELA_Human1.60316287
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55999313
33KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54298069
34ZNF274_21170338_ChIP-Seq_K562_Hela1.53908087
35IGF1R_20145208_ChIP-Seq_DFB_Human1.50104633
36TAF15_26573619_Chip-Seq_HEK293_Human1.45865996
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45645234
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.43952093
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.40837022
40P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38333570
41ERA_21632823_ChIP-Seq_H3396_Human1.37662245
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35108219
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33890260
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32803879
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32756267
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31719419
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29424861
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28146656
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27903423
50BCAT_22108803_ChIP-Seq_LS180_Human1.27838268
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.27804095
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26729320
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26182819
54GATA3_26560356_Chip-Seq_TH2_Human1.23850657
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23236221
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22976215
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22513519
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20749397
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.20698736
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.18997394
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14466688
62VDR_23849224_ChIP-Seq_CD4+_Human1.14050867
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12885482
64NCOR_22424771_ChIP-Seq_293T_Human1.12401348
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10953867
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.09948833
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09624151
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09462508
69TTF2_22483619_ChIP-Seq_HELA_Human1.09375937
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05457134
71CTCF_20526341_ChIP-Seq_ESCs_Human1.03793865
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.02169286
73MYC_19829295_ChIP-Seq_ESCs_Human1.00952206
74JUN_21703547_ChIP-Seq_K562_Human0.99246073
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98468850
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97027044
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94947807
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94833783
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.91700209
80P53_21459846_ChIP-Seq_SAOS-2_Human0.90631116
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.90607793
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90225315
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89426901
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89385303
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89194160
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88139087
87NANOG_19829295_ChIP-Seq_ESCs_Human0.86769181
88SOX2_19829295_ChIP-Seq_ESCs_Human0.86769181
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85816354
90FUS_26573619_Chip-Seq_HEK293_Human0.85250973
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84368250
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84184592
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84095497
94SOX2_21211035_ChIP-Seq_LN229_Human0.84058656
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83859799
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83828381
97SA1_27219007_Chip-Seq_Bcells_Human0.83564154
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83458976
99GATA3_21867929_ChIP-Seq_TH1_Mouse0.82749848
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80861378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.52677097
2MP0006292_abnormal_olfactory_placode4.52409142
3MP0009379_abnormal_foot_pigmentation3.91402357
4MP0003724_increased_susceptibility_to3.33764342
5MP0001346_abnormal_lacrimal_gland3.31008734
6MP0008875_abnormal_xenobiotic_pharmacok3.19197545
7MP0001348_abnormal_lacrimal_gland3.12110347
8MP0005379_endocrine/exocrine_gland_phen2.92041646
9MP0003646_muscle_fatigue2.91755415
10MP0006082_CNS_inflammation2.32605744
11MP0001873_stomach_inflammation2.29166042
12MP0005360_urolithiasis2.24046492
13MP0000383_abnormal_hair_follicle2.00901811
14MP0005377_hearing/vestibular/ear_phenot1.97132995
15MP0003878_abnormal_ear_physiology1.97132995
16MP0001293_anophthalmia1.89351822
17MP0008872_abnormal_physiological_respon1.84938712
18MP0002234_abnormal_pharynx_morphology1.73113201
19MP0003806_abnormal_nucleotide_metabolis1.67826581
20MP0000538_abnormal_urinary_bladder1.67410283
21MP0002837_dystrophic_cardiac_calcinosis1.66164083
22MP0005310_abnormal_salivary_gland1.65541240
23MP0008877_abnormal_DNA_methylation1.65190951
24MP0005167_abnormal_blood-brain_barrier1.65043243
25MP0001835_abnormal_antigen_presentation1.62286010
26MP0005000_abnormal_immune_tolerance1.55104150
27MP0000613_abnormal_salivary_gland1.52327565
28MP0001663_abnormal_digestive_system1.51693942
29MP0002148_abnormal_hypersensitivity_rea1.48461120
30MP0004145_abnormal_muscle_electrophysio1.47097885
31MP0002138_abnormal_hepatobiliary_system1.43000438
32MP0002736_abnormal_nociception_after1.42293104
33MP0001790_abnormal_immune_system1.37775253
34MP0005387_immune_system_phenotype1.37775253
35MP0001853_heart_inflammation1.32282475
36MP0004142_abnormal_muscle_tone1.31499865
37MP0001968_abnormal_touch/_nociception1.30156565
38MP0003787_abnormal_imprinting1.29703135
39MP0003279_aneurysm1.28757375
40MP0002277_abnormal_respiratory_mucosa1.26841968
41MP0003315_abnormal_perineum_morphology1.23658372
42MP0006072_abnormal_retinal_apoptosis1.17700369
43MP0004885_abnormal_endolymph1.17558025
44MP0003119_abnormal_digestive_system1.13749131
45MP0000566_synostosis1.12745000
46MP0002933_joint_inflammation1.11467486
47MP0001986_abnormal_taste_sensitivity1.09267162
48MP0005381_digestive/alimentary_phenotyp1.06057565
49MP0002733_abnormal_thermal_nociception1.05982808
50MP0001800_abnormal_humoral_immune1.05262144
51MP0009764_decreased_sensitivity_to1.05162527
52MP0006276_abnormal_autonomic_nervous1.04446774
53MP0001919_abnormal_reproductive_system1.03464027
54MP0010155_abnormal_intestine_physiology1.02075598
55MP0005389_reproductive_system_phenotype1.01210762
56MP0003300_gastrointestinal_ulcer1.00263357
57MP0004147_increased_porphyrin_level0.97492037
58MP0009785_altered_susceptibility_to0.94535715
59MP0001845_abnormal_inflammatory_respons0.94278936
60MP0000049_abnormal_middle_ear0.93592920
61MP0009250_abnormal_appendicular_skeleto0.93592116
62MP0001879_abnormal_lymphatic_vessel0.92209973
63MP0010678_abnormal_skin_adnexa0.91704986
64MP0005671_abnormal_response_to0.89986441
65MP0010030_abnormal_orbit_morphology0.89398835
66MP0001756_abnormal_urination0.88446332
67MP0001970_abnormal_pain_threshold0.87172220
68MP0002723_abnormal_immune_serum0.87040968
69MP0002272_abnormal_nervous_system0.84003796
70MP0002938_white_spotting0.83261962
71MP0002160_abnormal_reproductive_system0.83128914
72MP0002932_abnormal_joint_morphology0.81972024
73MP0004742_abnormal_vestibular_system0.80892741
74MP0005084_abnormal_gallbladder_morpholo0.79478137
75MP0005332_abnormal_amino_acid0.79122752
76MP0000470_abnormal_stomach_morphology0.79016233
77MP0010329_abnormal_lipoprotein_level0.78535534
78MP0002452_abnormal_antigen_presenting0.78467904
79MP0001905_abnormal_dopamine_level0.77555006
80MP0001944_abnormal_pancreas_morphology0.76086514
81MP0005025_abnormal_response_to0.74654088
82MP0005503_abnormal_tendon_morphology0.74432356
83MP0008789_abnormal_olfactory_epithelium0.73828159
84MP0002095_abnormal_skin_pigmentation0.71708339
85MP0003938_abnormal_ear_development0.71128275
86MP0009745_abnormal_behavioral_response0.70614863
87MP0002136_abnormal_kidney_physiology0.69900808
88MP0002282_abnormal_trachea_morphology0.66311775
89MP0000689_abnormal_spleen_morphology0.65271234
90MP0002098_abnormal_vibrissa_morphology0.65003496
91MP0002405_respiratory_system_inflammati0.64992883
92MP0005165_increased_susceptibility_to0.64886425
93MP0009643_abnormal_urine_homeostasis0.64562695
94MP0002420_abnormal_adaptive_immunity0.64528481
95MP0003122_maternal_imprinting0.64093359
96MP0002735_abnormal_chemical_nociception0.63323925
97MP0003011_delayed_dark_adaptation0.62893457
98MP0001819_abnormal_immune_cell0.62835777
99MP0001286_abnormal_eye_development0.62663754
100MP0008057_abnormal_DNA_replication0.62319061

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)6.91240020
2Hip dysplasia (HP:0001385)6.62888892
3Hypoplasia of the pons (HP:0012110)5.70663270
4Abnormality of the pons (HP:0007361)5.28897079
5Hip contracture (HP:0003273)5.01190767
6Abnormality of cells of the erythroid lineage (HP:0012130)4.49015999
7Achilles tendon contracture (HP:0001771)4.46691133
8Opisthotonus (HP:0002179)4.40159644
9Abnormality of the Achilles tendon (HP:0005109)4.05144295
10Poor suck (HP:0002033)3.90777319
11Limited hip movement (HP:0008800)3.83822898
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.77785272
13Parakeratosis (HP:0001036)3.76172564
14Asplenia (HP:0001746)3.71230198
15Macrocytic anemia (HP:0001972)3.66543621
16Stenosis of the external auditory canal (HP:0000402)3.56965682
17Abnormal number of erythroid precursors (HP:0012131)3.56690886
18Reticulocytopenia (HP:0001896)3.55633102
19Type 2 muscle fiber atrophy (HP:0003554)3.29875766
20Acute necrotizing encephalopathy (HP:0006965)3.29479906
21Supernumerary spleens (HP:0009799)3.28463965
22Increased hepatocellular lipid droplets (HP:0006565)3.06334430
23Hyperglycinemia (HP:0002154)3.06113642
24Molar tooth sign on MRI (HP:0002419)3.05036876
25Abnormality of midbrain morphology (HP:0002418)3.05036876
26Congenital, generalized hypertrichosis (HP:0004540)3.02512013
27Progressive macrocephaly (HP:0004481)2.72691479
28Dyskinesia (HP:0100660)2.72407352
29Abnormal mitochondria in muscle tissue (HP:0008316)2.71185049
30Lipid accumulation in hepatocytes (HP:0006561)2.69954287
31Muscle fiber atrophy (HP:0100295)2.69194977
32Restlessness (HP:0000711)2.68596720
33Knee flexion contracture (HP:0006380)2.66494359
34Pallor (HP:0000980)2.65980052
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63066874
36Impaired smooth pursuit (HP:0007772)2.60132053
37Renal Fanconi syndrome (HP:0001994)2.58869600
38Acute encephalopathy (HP:0006846)2.58311637
39Tubular atrophy (HP:0000092)2.53715134
40Abnormal drinking behavior (HP:0030082)2.51909691
41Polydipsia (HP:0001959)2.51909691
42Abnormal biliary tract physiology (HP:0012439)2.50467537
43Bile duct proliferation (HP:0001408)2.50467537
44Potter facies (HP:0002009)2.45047272
45Facial shape deformation (HP:0011334)2.45047272
46Mitochondrial inheritance (HP:0001427)2.44041977
47Poor speech (HP:0002465)2.42338794
48Elevated erythrocyte sedimentation rate (HP:0003565)2.40319316
49Scapular winging (HP:0003691)2.36204539
50Abnormality of the labia minora (HP:0012880)2.34170173
51Abnormality of the renal medulla (HP:0100957)2.33975260
52Septo-optic dysplasia (HP:0100842)2.33133193
53Tubulointerstitial fibrosis (HP:0005576)2.23392793
54Increased intramyocellular lipid droplets (HP:0012240)2.22610079
553-Methylglutaconic aciduria (HP:0003535)2.19604543
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19412908
57Gowers sign (HP:0003391)2.17832118
58Autoimmune thrombocytopenia (HP:0001973)2.16924921
59Nephronophthisis (HP:0000090)2.10640385
60Hypoplasia of the ulna (HP:0003022)2.10295958
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.09405005
62Increased CSF lactate (HP:0002490)2.07323803
63Poor eye contact (HP:0000817)2.03867732
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03077076
65Cerebral edema (HP:0002181)2.02059793
66Waddling gait (HP:0002515)2.00998961
67Oligodactyly (hands) (HP:0001180)2.00819667
68Short femoral neck (HP:0100864)2.00198322
69Decreased muscle mass (HP:0003199)1.95409753
70Sacral dimple (HP:0000960)1.94152877
71Abnormality of renal resorption (HP:0011038)1.92889795
72Thick lower lip vermilion (HP:0000179)1.92782025
73Abnormal rod and cone electroretinograms (HP:0008323)1.92141561
74Polyuria (HP:0000103)1.91548241
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90261836
76Short 4th metacarpal (HP:0010044)1.90261836
77Absent/shortened dynein arms (HP:0200106)1.89105695
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.89105695
79Testicular atrophy (HP:0000029)1.87561867
80Exertional dyspnea (HP:0002875)1.84969637
81Submucous cleft hard palate (HP:0000176)1.83973515
82Fatigable weakness (HP:0003473)1.83765386
83Abnormality of the neuromuscular junction (HP:0003398)1.83765386
84Hypoplasia of the brainstem (HP:0002365)1.83523835
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83523835
86Wide intermamillary distance (HP:0006610)1.82214006
87Overriding aorta (HP:0002623)1.81355414
88Spondylolisthesis (HP:0003302)1.79583451
89Increased muscle lipid content (HP:0009058)1.79261244
90Mesomelia (HP:0003027)1.78630732
91Mediastinal lymphadenopathy (HP:0100721)1.77239536
92Hypoplasia of the radius (HP:0002984)1.77037074
93Absent septum pellucidum (HP:0001331)1.76162023
94Renal dysplasia (HP:0000110)1.75713266
95Pancreatic fibrosis (HP:0100732)1.74333788
96Elfin facies (HP:0004428)1.73913625
97Abnormality of the phalanges of the 5th finger (HP:0004213)1.73722041
98Progressive microcephaly (HP:0000253)1.73310318
99Abnormality of the 4th metacarpal (HP:0010012)1.72085456
100Severe global developmental delay (HP:0011344)1.71720743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK16.36098500
2MAP4K13.87502693
3NLK3.30186967
4ADRBK22.91551721
5TESK12.08186319
6TAF12.01359217
7NEK11.97454019
8BMPR1B1.96721982
9PRKCG1.96613247
10ACVR1B1.92013659
11MAP4K21.89790870
12DYRK21.89207704
13SGK4941.86289576
14SGK2231.86289576
15ZAK1.79263711
16CSF1R1.76708405
17EPHB21.73197263
18NME21.71356933
19SGK21.69486391
20LRRK21.61016577
21TGFBR11.49026275
22WNK31.46739981
23PRKCQ1.32796420
24GRK11.29366472
25MUSK1.24908863
26CDC42BPA1.18582013
27WNK41.17782180
28ADRBK11.13702056
29TIE11.12833208
30MATK1.12710767
31SGK31.12408206
32PLK41.12092604
33DYRK1A1.11589234
34LYN1.11245083
35PKN11.08767967
36TXK1.06752754
37PLK21.04811645
38CSNK2A21.03571014
39STK241.00478474
40TLK11.00432541
41IKBKE0.96549669
42CSNK1G10.88685150
43RPS6KA50.86592480
44PASK0.83709587
45CSNK2A10.81976699
46LCK0.77716879
47CDC70.74017145
48SGK10.73471056
49INSRR0.72876034
50GRK70.71647300
51TEC0.70752136
52PIK3CA0.69761186
53NTRK20.68232383
54OBSCN0.68050874
55TSSK60.67495432
56BRAF0.65511725
57MINK10.64954004
58PINK10.64869787
59PDK20.62229196
60MYLK0.61821600
61IKBKB0.61531628
62CAMKK20.60731704
63BUB10.60700448
64CDK40.58223939
65TRIM280.56740975
66PAK10.54993546
67EPHA40.54888618
68MAP3K110.54540978
69CDK80.54062556
70PRKCA0.53769984
71STK160.51582394
72CSNK1A10.51320542
73BCKDK0.50316699
74CSK0.49103639
75ITK0.48412838
76PHKG20.48277580
77PHKG10.48277580
78VRK10.47456160
79VRK20.47238521
80RPS6KA60.45778252
81PRKCH0.45635588
82AKT30.45063133
83PDK10.44404187
84FES0.43497148
85ERBB20.43356445
86MAP3K90.42770498
87BTK0.41421492
88PIK3CG0.40060770
89DAPK30.39786439
90KIT0.39397399
91PRKACA0.39307837
92CAMK10.38880713
93SYK0.38655669
94STK390.38194085
95PIM10.35469577
96MAP3K40.35452134
97MAPK90.34994544
98WEE10.34806659
99PLK10.33863389
100FRK0.33794059

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.79453576
2Sulfur relay system_Homo sapiens_hsa041226.77398871
3Drug metabolism - other enzymes_Homo sapiens_hsa009833.42270669
4Pentose phosphate pathway_Homo sapiens_hsa000303.02070100
5Oxidative phosphorylation_Homo sapiens_hsa001902.37691289
6Hematopoietic cell lineage_Homo sapiens_hsa046402.21595267
7Pyrimidine metabolism_Homo sapiens_hsa002402.06417477
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00088672
9Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.94099301
10Parkinsons disease_Homo sapiens_hsa050121.87517880
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62834849
12Primary immunodeficiency_Homo sapiens_hsa053401.62552043
13Cardiac muscle contraction_Homo sapiens_hsa042601.51108132
14Measles_Homo sapiens_hsa051621.49321670
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47637121
16Allograft rejection_Homo sapiens_hsa053301.47029388
17Graft-versus-host disease_Homo sapiens_hsa053321.42149854
18Fat digestion and absorption_Homo sapiens_hsa049751.41739849
19Basal transcription factors_Homo sapiens_hsa030221.41594151
20Autoimmune thyroid disease_Homo sapiens_hsa053201.40848218
21Asthma_Homo sapiens_hsa053101.39948407
22DNA replication_Homo sapiens_hsa030301.37267548
23Alzheimers disease_Homo sapiens_hsa050101.32862266
24Type I diabetes mellitus_Homo sapiens_hsa049401.30612665
25Huntingtons disease_Homo sapiens_hsa050161.20493288
26Linoleic acid metabolism_Homo sapiens_hsa005911.20061127
27Caffeine metabolism_Homo sapiens_hsa002321.15025798
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.12778940
29Nicotine addiction_Homo sapiens_hsa050331.11391011
30Butanoate metabolism_Homo sapiens_hsa006501.03861706
31Protein export_Homo sapiens_hsa030600.97441976
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94396401
33Glycerolipid metabolism_Homo sapiens_hsa005610.94220136
34Jak-STAT signaling pathway_Homo sapiens_hsa046300.93578001
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93532220
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90537670
37Proteasome_Homo sapiens_hsa030500.88780367
38RNA degradation_Homo sapiens_hsa030180.82034613
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80445037
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79479899
41Apoptosis_Homo sapiens_hsa042100.73977155
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73309463
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72153531
44Tryptophan metabolism_Homo sapiens_hsa003800.71143205
45Phototransduction_Homo sapiens_hsa047440.67811181
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67410576
47Chemical carcinogenesis_Homo sapiens_hsa052040.66788995
48Regulation of autophagy_Homo sapiens_hsa041400.66690244
49Rheumatoid arthritis_Homo sapiens_hsa053230.66431116
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63708335
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63395193
52Sulfur metabolism_Homo sapiens_hsa009200.62506344
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59977367
54Hedgehog signaling pathway_Homo sapiens_hsa043400.58446950
55Malaria_Homo sapiens_hsa051440.57893716
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56084866
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53691541
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53535699
59Purine metabolism_Homo sapiens_hsa002300.51318503
60Thyroid cancer_Homo sapiens_hsa052160.49963960
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.48342333
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.47622933
63Influenza A_Homo sapiens_hsa051640.47535095
64Nitrogen metabolism_Homo sapiens_hsa009100.46766158
65Metabolic pathways_Homo sapiens_hsa011000.46568048
66Olfactory transduction_Homo sapiens_hsa047400.45624439
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45508813
68Systemic lupus erythematosus_Homo sapiens_hsa053220.45152384
69Retinol metabolism_Homo sapiens_hsa008300.45074393
70Staphylococcus aureus infection_Homo sapiens_hsa051500.43622110
71T cell receptor signaling pathway_Homo sapiens_hsa046600.42943811
72One carbon pool by folate_Homo sapiens_hsa006700.41022957
73Arachidonic acid metabolism_Homo sapiens_hsa005900.40234564
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39914940
75Taste transduction_Homo sapiens_hsa047420.39609815
76Basal cell carcinoma_Homo sapiens_hsa052170.39479027
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39454978
78RNA polymerase_Homo sapiens_hsa030200.39393372
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37534206
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.36767546
81beta-Alanine metabolism_Homo sapiens_hsa004100.36026165
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35485292
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33671209
84RNA transport_Homo sapiens_hsa030130.32407356
85Morphine addiction_Homo sapiens_hsa050320.32143624
86Legionellosis_Homo sapiens_hsa051340.30985395
87Fanconi anemia pathway_Homo sapiens_hsa034600.30879662
88Serotonergic synapse_Homo sapiens_hsa047260.27647648
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24878159
90Collecting duct acid secretion_Homo sapiens_hsa049660.24795286
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24181027
92Antigen processing and presentation_Homo sapiens_hsa046120.23409403
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.22070267
94Gastric acid secretion_Homo sapiens_hsa049710.21586055
95Protein digestion and absorption_Homo sapiens_hsa049740.20940555
96Nucleotide excision repair_Homo sapiens_hsa034200.19931397
97Glutathione metabolism_Homo sapiens_hsa004800.16880634
98Tyrosine metabolism_Homo sapiens_hsa003500.16229038
99Peroxisome_Homo sapiens_hsa041460.15293163
100Chemokine signaling pathway_Homo sapiens_hsa040620.15060215

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