ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	9.79041903
2	cell wall macromolecule metabolic process (GO:0044036)	8.05893094
3	cellular response to nicotine (GO:0071316)	7.39424630
4	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	6.56009789
5	regulation of integrin activation (GO:0033623)	6.30622797
6	cartilage morphogenesis (GO:0060536)	6.19997246
7	photoreceptor cell differentiation (GO:0046530)	5.61125483
8	eye photoreceptor cell differentiation (GO:0001754)	5.61125483
9	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	5.47521925
10	thrombin receptor signaling pathway (GO:0070493)	5.38991675
11	protoporphyrinogen IX metabolic process (GO:0046501)	5.23910726
12	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	5.12346096
13	erythrocyte maturation (GO:0043249)	5.00303629
14	regulation of centriole replication (GO:0046599)	4.87015329
15	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	4.85783849
16	nuclear pore complex assembly (GO:0051292)	4.77890819
17	positive regulation of meiosis (GO:0045836)	4.68928785
18	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.55501990
19	response to phenylpropanoid (GO:0080184)	4.41272670
20	positive regulation of meiotic cell cycle (GO:0051446)	4.34280483
21	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.34097671
22	positive regulation of BMP signaling pathway (GO:0030513)	4.19147533
23	oxygen transport (GO:0015671)	4.10038293
24	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.06827640
25	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	4.04274594
26	positive regulation of signal transduction by p53 class mediator (GO:1901798)	4.01474918
27	nuclear pore organization (GO:0006999)	4.01415052
28	monoubiquitinated protein deubiquitination (GO:0035520)	3.93259479
29	cellular protein complex localization (GO:0034629)	3.87487929
30	mesenchymal cell proliferation (GO:0010463)	3.80251891
31	synapsis (GO:0007129)	3.76277861
32	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.71204749
33	regulation of RNA export from nucleus (GO:0046831)	3.70291807
34	positive regulation of coagulation (GO:0050820)	3.64369510
35	anterior/posterior axis specification, embryo (GO:0008595)	3.62196196
36	porphyrin-containing compound metabolic process (GO:0006778)	3.55463719
37	protein complex localization (GO:0031503)	3.53921264
38	cytoplasmic mRNA processing body assembly (GO:0033962)	3.52556449
39	positive regulation of blood coagulation (GO:0030194)	3.52200496
40	positive regulation of hemostasis (GO:1900048)	3.52200496
41	regulation of platelet activation (GO:0010543)	3.51790775
42	signal transduction involved in regulation of gene expression (GO:0023019)	3.50373778
43	pore complex assembly (GO:0046931)	3.48383559
44	heme metabolic process (GO:0042168)	3.46633357
45	regulation of mitotic spindle organization (GO:0060236)	3.45370879
46	organelle disassembly (GO:1903008)	3.43805256
47	porphyrin-containing compound biosynthetic process (GO:0006779)	3.43084909
48	cGMP-mediated signaling (GO:0019934)	3.41171929
49	gas transport (GO:0015669)	3.40117077
50	centriole replication (GO:0007099)	3.35277740
51	low-density lipoprotein particle clearance (GO:0034383)	3.30697674
52	regulation of meiosis I (GO:0060631)	3.29585165
53	ribonucleoprotein complex disassembly (GO:0032988)	3.27541982
54	regulation of meiosis (GO:0040020)	3.25551524
55	negative regulation of activin receptor signaling pathway (GO:0032926)	3.24787500
56	positive regulation of myoblast differentiation (GO:0045663)	3.23135870
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	3.17752321
58	collecting duct development (GO:0072044)	3.15328142
59	negative regulation of Ras GTPase activity (GO:0034261)	3.15075011
60	regulation of spindle organization (GO:0090224)	3.11462908
61	negative regulation of T-helper cell differentiation (GO:0045623)	3.09540274
62	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.09540274
63	pituitary gland development (GO:0021983)	2.99889950
64	mitotic spindle checkpoint (GO:0071174)	2.95505356
65	detection of temperature stimulus (GO:0016048)	2.94444773
66	heme biosynthetic process (GO:0006783)	2.94122807
67	tetrapyrrole biosynthetic process (GO:0033014)	2.93335286
68	heparin biosynthetic process (GO:0030210)	2.93303108
69	heparin metabolic process (GO:0030202)	2.93303108
70	negative regulation of striated muscle cell differentiation (GO:0051154)	2.91805498
71	erythrocyte development (GO:0048821)	2.91793119
72	vasculature development (GO:0001944)	2.91614198
73	definitive hemopoiesis (GO:0060216)	2.91508012
74	phagocytosis, recognition (GO:0006910)	2.90542230
75	dendritic spine morphogenesis (GO:0060997)	2.87371910
76	blood vessel maturation (GO:0001955)	2.87246729
77	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.87071163
78	mitochondrial fission (GO:0000266)	2.86879041
79	metaphase plate congression (GO:0051310)	2.85595105
80	neural tube formation (GO:0001841)	2.85133181
81	regulation of meiotic cell cycle (GO:0051445)	2.80384081
82	mitotic sister chromatid segregation (GO:0000070)	2.79556042
83	phosphatidylethanolamine metabolic process (GO:0046337)	2.77105990
84	negative regulation of DNA repair (GO:0045738)	2.76962778
85	regulation of nucleobase-containing compound transport (GO:0032239)	2.75951400
86	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.74951121
87	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.74951121
88	protein K11-linked ubiquitination (GO:0070979)	2.73871629
89	establishment of chromosome localization (GO:0051303)	2.72400772
90	regulation of exit from mitosis (GO:0007096)	2.70391135
91	sister chromatid segregation (GO:0000819)	2.70028844
92	regulation of chromosome segregation (GO:0051983)	2.67666173
93	spindle checkpoint (GO:0031577)	2.67601526
94	histone H2A acetylation (GO:0043968)	2.64974526
95	megakaryocyte development (GO:0035855)	2.63905093
96	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.63064249
97	negative regulation of chromosome segregation (GO:0051985)	2.63046594
98	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.63015908
99	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.62249420
100	negative regulation of sister chromatid segregation (GO:0033046)	2.62249420

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.01764101
2	GATA1_22025678_ChIP-Seq_K562_Human	5.02528866
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.83146963
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.34682866
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.06259407
6	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.83562541
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.83562541
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.83562541
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.63478091
10	IGF1R_20145208_ChIP-Seq_DFB_Human	3.13184287
11	VDR_22108803_ChIP-Seq_LS180_Human	3.05172032
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.92575282
13	ZNF263_19887448_ChIP-Seq_K562_Human	2.92209050
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.85759019
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.69188059
16	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.65548087
17	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.21335994
18	E2F7_22180533_ChIP-Seq_HELA_Human	2.10455748
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06634576
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97192912
21	SCL_19346495_ChIP-Seq_HPC-7_Human	1.96445936
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90606153
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.89639025
24	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.88043390
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.85493880
26	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.78736202
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.76597812
28	GATA1_19941826_ChIP-Seq_K562_Human	1.75150016
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69031576
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.62848160
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.60676386
32	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.57365601
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57073855
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.56741271
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54264914
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54018258
37	GATA2_19941826_ChIP-Seq_K562_Human	1.47512581
38	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.40847450
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36682336
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32459009
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.32364131
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31436115
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30606123
44	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.26837132
45	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25975970
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25224328
47	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.25156061
48	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.24697830
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.24575259
50	GBX2_23144817_ChIP-Seq_PC3_Human	1.24446622
51	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.23682116
52	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21589032
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.21279459
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20818593
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.18992783
56	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.18852684
57	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17158814
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16146881
59	AR_21909140_ChIP-Seq_LNCAP_Human	1.15384250
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15242556
61	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.12460159
62	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11955466
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08542928
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05748519
65	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.04804433
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03209707
67	FUS_26573619_Chip-Seq_HEK293_Human	1.01946431
68	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.01611543
69	EWS_26573619_Chip-Seq_HEK293_Human	0.99931597
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.99699048
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97120208
72	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.95839855
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.95554189
74	XRN2_22483619_ChIP-Seq_HELA_Human	0.94086006
75	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.93727799
76	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.91342882
77	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.90211231
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89578125
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.86938414
80	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.84498936
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83284895
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81743470
83	TP53_16413492_ChIP-PET_HCT116_Human	0.81454523
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.78493437
85	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.77888664
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.76830075
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.75562252
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.75492006
89	P300_19829295_ChIP-Seq_ESCs_Human	0.75461122
90	CIITA_25753668_ChIP-Seq_RAJI_Human	0.75063513
91	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.73896415
92	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.73364608
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.72857850
94	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.72731589
95	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.71183016
96	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.69381577
97	STAT3_23295773_ChIP-Seq_U87_Human	0.69140836
98	SOX9_26525672_Chip-Seq_HEART_Mouse	0.67976728
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.66058350
100	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.64861874

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	6.04950889
2	MP0005083_abnormal_biliary_tract	5.49315160
3	MP0005171_absent_coat_pigmentation	5.23942284
4	MP0009697_abnormal_copulation	4.74132642
5	MP0000372_irregular_coat_pigmentation	3.62315623
6	MP0003136_yellow_coat_color	3.60752584
7	MP0003890_abnormal_embryonic-extraembry	2.51721652
8	MP0005076_abnormal_cell_differentiation	2.40026010
9	MP0003656_abnormal_erythrocyte_physiolo	2.36790838
10	MP0003111_abnormal_nucleus_morphology	2.04444642
11	MP0008995_early_reproductive_senescence	2.00773915
12	MP0008004_abnormal_stomach_pH	1.94147919
13	MP0005464_abnormal_platelet_physiology	1.92047400
14	MP0003221_abnormal_cardiomyocyte_apopto	1.84976702
15	MP0001968_abnormal_touch/_nociception	1.77157743
16	MP0002938_white_spotting	1.76822846
17	MP0002177_abnormal_outer_ear	1.62328861
18	MP0001851_eye_inflammation	1.61965717
19	MP0002736_abnormal_nociception_after	1.61798952
20	MP0003303_peritoneal_inflammation	1.61552500
21	MP0005174_abnormal_tail_pigmentation	1.58235363
22	MP0005084_abnormal_gallbladder_morpholo	1.53000223
23	MP0003828_pulmonary_edema	1.45466171
24	MP0008057_abnormal_DNA_replication	1.44556184
25	MP0004133_heterotaxia	1.42532674
26	MP0003077_abnormal_cell_cycle	1.35828370
27	MP0003724_increased_susceptibility_to	1.34366739
28	MP0001730_embryonic_growth_arrest	1.33188248
29	MP0005187_abnormal_penis_morphology	1.31788065
30	MP0006138_congestive_heart_failure	1.30957121
31	MP0005380_embryogenesis_phenotype	1.29931892
32	MP0001672_abnormal_embryogenesis/_devel	1.29931892
33	MP0002095_abnormal_skin_pigmentation	1.26812573
34	MP0004957_abnormal_blastocyst_morpholog	1.19083955
35	MP0001188_hyperpigmentation	1.19047666
36	MP0005623_abnormal_meninges_morphology	1.18894042
37	MP0005058_abnormal_lysosome_morphology	1.14556898
38	MP0009703_decreased_birth_body	1.13967514
39	MP0003984_embryonic_growth_retardation	1.13455155
40	MP0000631_abnormal_neuroendocrine_gland	1.12604992
41	MP0002396_abnormal_hematopoietic_system	1.12050011
42	MP0010094_abnormal_chromosome_stability	1.10258844
43	MP0001697_abnormal_embryo_size	1.04163985
44	MP0008058_abnormal_DNA_repair	1.03454832
45	MP0002088_abnormal_embryonic_growth/wei	1.02326780
46	MP0003943_abnormal_hepatobiliary_system	1.02107251
47	MP0002877_abnormal_melanocyte_morpholog	1.00883046
48	MP0001545_abnormal_hematopoietic_system	0.98447538
49	MP0005397_hematopoietic_system_phenotyp	0.98447538
50	MP0003385_abnormal_body_wall	0.97003450
51	MP0002086_abnormal_extraembryonic_tissu	0.95767301
52	MP0006035_abnormal_mitochondrial_morpho	0.94996883
53	MP0003693_abnormal_embryo_hatching	0.93000573
54	MP0002080_prenatal_lethality	0.92637864
55	MP0000015_abnormal_ear_pigmentation	0.91868377
56	MP0003186_abnormal_redox_activity	0.90800017
57	MP0001919_abnormal_reproductive_system	0.89459921
58	MP0002925_abnormal_cardiovascular_devel	0.87377928
59	MP0002092_abnormal_eye_morphology	0.86554023
60	MP0001529_abnormal_vocalization	0.84335032
61	MP0000343_altered_response_to	0.82607175
62	MP0003567_abnormal_fetal_cardiomyocyte	0.82413195
63	MP0001915_intracranial_hemorrhage	0.81831407
64	MP0008932_abnormal_embryonic_tissue	0.80796581
65	MP0001293_anophthalmia	0.80629182
66	MP0002697_abnormal_eye_size	0.79598314
67	MP0003786_premature_aging	0.78876346
68	MP0002085_abnormal_embryonic_tissue	0.78548202
69	MP0002075_abnormal_coat/hair_pigmentati	0.75998758
70	MP0004145_abnormal_muscle_electrophysio	0.75105894
71	MP0002128_abnormal_blood_circulation	0.74993141
72	MP0000313_abnormal_cell_death	0.74587938
73	MP0000490_abnormal_crypts_of	0.74373463
74	MP0010630_abnormal_cardiac_muscle	0.73752921
75	MP0004185_abnormal_adipocyte_glucose	0.73297281
76	MP0002132_abnormal_respiratory_system	0.72738399
77	MP0000428_abnormal_craniofacial_morphol	0.72319635
78	MP0005385_cardiovascular_system_phenoty	0.71235535
79	MP0001544_abnormal_cardiovascular_syste	0.71235535
80	MP0003698_abnormal_male_reproductive	0.71097009
81	MP0004130_abnormal_muscle_cell	0.70816537
82	MP0004808_abnormal_hematopoietic_stem	0.70472108
83	MP0001191_abnormal_skin_condition	0.69861910
84	MP0004215_abnormal_myocardial_fiber	0.68902690
85	MP0001286_abnormal_eye_development	0.68751334
86	MP0000689_abnormal_spleen_morphology	0.68108779
87	MP0005670_abnormal_white_adipose	0.67700063
88	MP0002084_abnormal_developmental_patter	0.67420264
89	MP0004036_abnormal_muscle_relaxation	0.67032904
90	MP0003718_maternal_effect	0.66221524
91	MP0000377_abnormal_hair_follicle	0.65745452
92	MP0000266_abnormal_heart_morphology	0.65531637
93	MP0000350_abnormal_cell_proliferation	0.63038971
94	MP0002722_abnormal_immune_system	0.61244737
95	MP0002127_abnormal_cardiovascular_syste	0.61157886
96	MP0000569_abnormal_digit_pigmentation	0.61152340
97	MP0005410_abnormal_fertilization	0.59925744
98	MP0009931_abnormal_skin_appearance	0.59224741
99	MP0005621_abnormal_cell_physiology	0.59065693
100	MP0001542_abnormal_bone_strength	0.58625111

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	8.52961385
2	Abdominal situs inversus (HP:0003363)	6.54267802
3	Abnormality of abdominal situs (HP:0011620)	6.54267802
4	Abnormality of the heme biosynthetic pathway (HP:0010472)	6.44426675
5	Pigmentary retinal degeneration (HP:0001146)	5.75874226
6	Supernumerary spleens (HP:0009799)	4.56023307
7	Ridged nail (HP:0001807)	4.24227964
8	Short humerus (HP:0005792)	4.21134328
9	Aplasia/hypoplasia of the humerus (HP:0006507)	3.75779561
10	Poikilocytosis (HP:0004447)	3.69360312
11	Increased mean platelet volume (HP:0011877)	3.67763208
12	Premature skin wrinkling (HP:0100678)	3.51280125
13	Paralysis (HP:0003470)	3.44334967
14	Abnormal platelet volume (HP:0011876)	3.38150682
15	Absent radius (HP:0003974)	3.36276990
16	Anhidrosis (HP:0000970)	3.35995605
17	Tetraparesis (HP:0002273)	3.32364666
18	Curly hair (HP:0002212)	3.28146851
19	Prolonged bleeding time (HP:0003010)	3.23248440
20	Aplasia involving forearm bones (HP:0009822)	3.11330986
21	Absent forearm bone (HP:0003953)	3.11330986
22	Reticulocytosis (HP:0001923)	2.89091006
23	Ileus (HP:0002595)	2.87386966
24	Absent eyebrow (HP:0002223)	2.79344819
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.78671086
26	Abnormality of alanine metabolism (HP:0010916)	2.78671086
27	Hyperalaninemia (HP:0003348)	2.78671086
28	Hypochromic microcytic anemia (HP:0004840)	2.58953289
29	White forelock (HP:0002211)	2.54174031
30	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.52203679
31	Volvulus (HP:0002580)	2.46259966
32	Asplenia (HP:0001746)	2.45006640
33	Abnormal hair whorl (HP:0010721)	2.44791656
34	Microvesicular hepatic steatosis (HP:0001414)	2.41363122
35	Postural instability (HP:0002172)	2.37860895
36	Rhabdomyosarcoma (HP:0002859)	2.31723291
37	Polycythemia (HP:0001901)	2.30352947
38	Orthostatic hypotension (HP:0001278)	2.27862191
39	Skull defect (HP:0001362)	2.27117740
40	Respiratory difficulties (HP:0002880)	2.25651812
41	Sensory axonal neuropathy (HP:0003390)	2.24414434
42	Patchy hypopigmentation of hair (HP:0011365)	2.21755549
43	Proximal placement of thumb (HP:0009623)	2.21466631
44	Abnormality of primary teeth (HP:0006481)	2.19516026
45	Supernumerary ribs (HP:0005815)	2.17034733
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15898705
47	Genetic anticipation (HP:0003743)	2.15857866
48	Abnormal gallbladder physiology (HP:0012438)	2.15439704
49	Cholecystitis (HP:0001082)	2.15439704
50	Microcytic anemia (HP:0001935)	2.15310541
51	Progressive external ophthalmoplegia (HP:0000590)	2.09447786
52	Medulloblastoma (HP:0002885)	2.09191350
53	Cholelithiasis (HP:0001081)	2.09078853
54	Abnormality of reticulocytes (HP:0004312)	2.08652199
55	Diaphragmatic weakness (HP:0009113)	2.07215525
56	Supernumerary bones of the axial skeleton (HP:0009144)	2.05511664
57	Deviation of the thumb (HP:0009603)	2.05400852
58	Neoplasm of striated muscle (HP:0009728)	1.99956893
59	Absent/shortened dynein arms (HP:0200106)	1.98382947
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98382947
61	Oligodactyly (hands) (HP:0001180)	1.97133186
62	Slow saccadic eye movements (HP:0000514)	1.96944072
63	Short chin (HP:0000331)	1.95638215
64	Bladder neoplasm (HP:0009725)	1.94983832
65	Bladder carcinoma (HP:0002862)	1.94983832
66	Uterine leiomyosarcoma (HP:0002891)	1.93025322
67	Leiomyosarcoma (HP:0100243)	1.93025322
68	Progressive inability to walk (HP:0002505)	1.91960706
69	Fine hair (HP:0002213)	1.91494599
70	Renal cortical cysts (HP:0000803)	1.90558030
71	Agnosia (HP:0010524)	1.89339608
72	Intestinal atresia (HP:0011100)	1.87937787
73	Spinal muscular atrophy (HP:0007269)	1.85252893
74	Abnormal hemoglobin (HP:0011902)	1.83926500
75	Osteomalacia (HP:0002749)	1.81247571
76	Tented upper lip vermilion (HP:0010804)	1.81180217
77	Biliary tract neoplasm (HP:0100574)	1.80383591
78	Abnormal gallbladder morphology (HP:0012437)	1.79501885
79	Abnormal ciliary motility (HP:0012262)	1.78708260
80	Hypoplastic pelvis (HP:0008839)	1.76919226
81	Short nail (HP:0001799)	1.75972292
82	Cellular immunodeficiency (HP:0005374)	1.72054014
83	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.70618533
84	Transitional cell carcinoma of the bladder (HP:0006740)	1.70501469
85	Abnormality of the upper arm (HP:0001454)	1.70429098
86	Uterine neoplasm (HP:0010784)	1.70146688
87	Dysautonomia (HP:0002459)	1.69145603
88	Neoplasm of the oral cavity (HP:0100649)	1.68056314
89	Abnormality of the humerus (HP:0003063)	1.67584093
90	Premature graying of hair (HP:0002216)	1.67251166
91	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.66129558
92	Short 4th metacarpal (HP:0010044)	1.66129558
93	Myelodysplasia (HP:0002863)	1.66116347
94	Amelogenesis imperfecta (HP:0000705)	1.65003235
95	Basal cell carcinoma (HP:0002671)	1.63809611
96	Duodenal stenosis (HP:0100867)	1.62864257
97	Small intestinal stenosis (HP:0012848)	1.62864257
98	Myelomeningocele (HP:0002475)	1.62685558
99	Spontaneous hematomas (HP:0007420)	1.62518807
100	Acanthocytosis (HP:0001927)	1.61909864

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	9.07958034
2	EPHB1	3.94871298
3	PLK4	3.78587482
4	PDK2	3.33723197
5	EPHA3	3.05582658
6	BCKDK	2.67390785
7	MAP3K6	2.44714256
8	PNCK	2.42606890
9	MAP2K7	2.27086975
10	MAP3K4	2.16516409
11	TNIK	2.14532250
12	NEK1	2.06349777
13	MAP3K11	1.89678455
14	ERBB4	1.74816969
15	MAP2K4	1.62396593
16	PBK	1.57799631
17	CAMK1G	1.56428119
18	DYRK3	1.37753112
19	MKNK1	1.19236458
20	WNK1	1.18874239
21	ZAK	1.16061807
22	MAP3K12	1.15735887
23	PLK3	1.14440887
24	MAP3K5	1.11158876
25	SGK2	1.08562572
26	AKT3	1.07885326
27	TTK	1.04577917
28	PINK1	0.99781073
29	EIF2AK1	0.97695981
30	GRK6	0.97551997
31	SRPK1	0.95329829
32	PLK1	0.91676178
33	PIM1	0.83872124
34	TEC	0.82948078
35	CSNK1A1L	0.81165101
36	CDK3	0.80700050
37	CDK12	0.80436716
38	CDK6	0.78585022
39	STK16	0.77924724
40	VRK1	0.77618726
41	MAPK15	0.77518881
42	CCNB1	0.73648268
43	SCYL2	0.73610283
44	BTK	0.72852226
45	RAF1	0.71788359
46	BMX	0.71006134
47	STK4	0.70031147
48	SGK3	0.67922911
49	SIK2	0.66854357
50	MOS	0.66500468
51	NEK9	0.66155416
52	MAP4K1	0.64670977
53	RIPK4	0.61129196
54	MKNK2	0.60293028
55	GRK1	0.58861656
56	TAOK3	0.58673988
57	BRSK2	0.57658671
58	TIE1	0.56032915
59	BLK	0.54456604
60	AURKB	0.53188995
61	ERBB2	0.49402339
62	MARK3	0.45094615
63	TLK1	0.44614360
64	TYRO3	0.43929140
65	YES1	0.43687368
66	CDK4	0.42321330
67	CSNK1G3	0.41650982
68	PIM2	0.40904389
69	HIPK2	0.40642079
70	PAK1	0.40198887
71	ACVR1B	0.39814291
72	CLK1	0.37471246
73	CSNK1G2	0.35028688
74	SGK223	0.34969159
75	SGK494	0.34969159
76	MAP2K3	0.31874689
77	TSSK6	0.31440981
78	CDK19	0.30544977
79	PAK6	0.30333092
80	PAK2	0.30286119
81	CDK8	0.30047236
82	WNK4	0.30016148
83	CSNK1G1	0.29945536
84	MATK	0.28330264
85	MELK	0.27351131
86	MAP3K1	0.26369153
87	ATM	0.25122640
88	CAMK4	0.25086713
89	RPS6KA1	0.24572671
90	NUAK1	0.22548361
91	ITK	0.21751932
92	CHEK2	0.21614942
93	ZAP70	0.21418985
94	FGR	0.18556837
95	SYK	0.18238701
96	TGFBR1	0.18159927
97	CDK1	0.17599308
98	BRAF	0.17274883
99	GSK3A	0.16844369
100	RPS6KA5	0.15871098

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	4.02229786
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.96715062
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.81134906
4	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.78856422
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.39618712
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37926420
7	Olfactory transduction_Homo sapiens_hsa04740	2.26119651
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.11316700
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.09666535
10	Cell cycle_Homo sapiens_hsa04110	2.07129536
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.04503367
12	Basal transcription factors_Homo sapiens_hsa03022	1.87019813
13	Protein export_Homo sapiens_hsa03060	1.82710280
14	Malaria_Homo sapiens_hsa05144	1.74910397
15	RNA transport_Homo sapiens_hsa03013	1.73912500
16	Propanoate metabolism_Homo sapiens_hsa00640	1.62314032
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.52564494
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50944746
19	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.49385116
20	Colorectal cancer_Homo sapiens_hsa05210	1.43614384
21	Acute myeloid leukemia_Homo sapiens_hsa05221	1.42623106
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.35200854
23	Base excision repair_Homo sapiens_hsa03410	1.32910685
24	RNA degradation_Homo sapiens_hsa03018	1.30722883
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.27061864
26	Spliceosome_Homo sapiens_hsa03040	1.22000653
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.21338132
28	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.17136265
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.14583527
30	Basal cell carcinoma_Homo sapiens_hsa05217	1.14157585
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.12828212
32	ErbB signaling pathway_Homo sapiens_hsa04012	1.10861783
33	p53 signaling pathway_Homo sapiens_hsa04115	1.05740222
34	HTLV-I infection_Homo sapiens_hsa05166	1.05663189
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02619029
36	Huntingtons disease_Homo sapiens_hsa05016	0.99824070
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.96816786
38	Melanogenesis_Homo sapiens_hsa04916	0.95338894
39	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91723917
40	Thyroid cancer_Homo sapiens_hsa05216	0.91470533
41	Taste transduction_Homo sapiens_hsa04742	0.91367395
42	Sulfur relay system_Homo sapiens_hsa04122	0.90818250
43	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.90359839
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.89483452
45	Hepatitis B_Homo sapiens_hsa05161	0.88182834
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87242094
47	Apoptosis_Homo sapiens_hsa04210	0.86737120
48	Endometrial cancer_Homo sapiens_hsa05213	0.82268209
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.81397714
50	Oocyte meiosis_Homo sapiens_hsa04114	0.80648341
51	Ribosome_Homo sapiens_hsa03010	0.80457201
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.80333709
53	Parkinsons disease_Homo sapiens_hsa05012	0.79651609
54	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.78087643
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76784155
56	One carbon pool by folate_Homo sapiens_hsa00670	0.72154296
57	FoxO signaling pathway_Homo sapiens_hsa04068	0.71960675
58	Mismatch repair_Homo sapiens_hsa03430	0.71570182
59	Alcoholism_Homo sapiens_hsa05034	0.70706625
60	Platelet activation_Homo sapiens_hsa04611	0.69387632
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.69164147
62	Choline metabolism in cancer_Homo sapiens_hsa05231	0.66862767
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64938949
64	Homologous recombination_Homo sapiens_hsa03440	0.64861014
65	Adherens junction_Homo sapiens_hsa04520	0.64590446
66	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.64528057
67	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.63290159
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.62833422
69	Bladder cancer_Homo sapiens_hsa05219	0.62602685
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62535830
71	Legionellosis_Homo sapiens_hsa05134	0.61469305
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60469575
73	Prostate cancer_Homo sapiens_hsa05215	0.59400214
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58832851
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.58508506
76	Shigellosis_Homo sapiens_hsa05131	0.58484433
77	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.57801942
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55907624
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.55804809
80	Carbon metabolism_Homo sapiens_hsa01200	0.55130740
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53046264
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.52832015
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50005160
84	Long-term depression_Homo sapiens_hsa04730	0.48351904
85	Renal cell carcinoma_Homo sapiens_hsa05211	0.48213844
86	Pancreatic cancer_Homo sapiens_hsa05212	0.48146282
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44713786
88	Chemokine signaling pathway_Homo sapiens_hsa04062	0.44616172
89	Non-small cell lung cancer_Homo sapiens_hsa05223	0.44175858
90	Purine metabolism_Homo sapiens_hsa00230	0.44002914
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.43744018
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43654925
93	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.43240183
94	Pathways in cancer_Homo sapiens_hsa05200	0.42799622
95	TNF signaling pathway_Homo sapiens_hsa04668	0.40965974
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38149309
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.37255284
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34510934
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31692507
100	Insulin resistance_Homo sapiens_hsa04931	0.30495855

RPS12P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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