RPS12P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.52223789
2translational termination (GO:0006415)9.09952593
3ribosomal small subunit biogenesis (GO:0042274)8.31348812
4translational elongation (GO:0006414)7.86606055
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.34351512
6cotranslational protein targeting to membrane (GO:0006613)7.17383078
7protein targeting to ER (GO:0045047)7.17151402
8behavioral response to nicotine (GO:0035095)7.08928323
9ribosomal small subunit assembly (GO:0000028)7.03647535
10cellular protein complex disassembly (GO:0043624)6.97613907
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.84644066
12viral life cycle (GO:0019058)6.81013445
13protein localization to endoplasmic reticulum (GO:0070972)6.64899376
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.45915621
15positive regulation of prostaglandin secretion (GO:0032308)6.37218061
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.96065660
17regulation of glucocorticoid secretion (GO:2000849)5.88931795
18histone H4-K12 acetylation (GO:0043983)5.81442552
19protein complex disassembly (GO:0043241)5.80463033
20translational initiation (GO:0006413)5.59393423
21macromolecular complex disassembly (GO:0032984)5.32310229
22regulation of prostaglandin secretion (GO:0032306)5.31253630
23regulation of corticosteroid hormone secretion (GO:2000846)4.85041372
24protein targeting to membrane (GO:0006612)4.67634228
25maturation of SSU-rRNA (GO:0030490)4.61732741
26ribosomal large subunit biogenesis (GO:0042273)4.56477344
27positive regulation of icosanoid secretion (GO:0032305)4.55576751
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51178815
29energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49388950
30ATP synthesis coupled proton transport (GO:0015986)4.49388950
31translation (GO:0006412)4.34979921
32positive regulation of fatty acid transport (GO:2000193)4.16391846
33nucleotide salvage (GO:0043173)4.11785272
34nuclear-transcribed mRNA catabolic process (GO:0000956)4.04648758
35nucleoside salvage (GO:0043174)3.96789793
36regulation of posttranscriptional gene silencing (GO:0060147)3.82390613
37regulation of gene silencing by miRNA (GO:0060964)3.82390613
38regulation of gene silencing by RNA (GO:0060966)3.82390613
39positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.81540324
40mRNA catabolic process (GO:0006402)3.80202353
41valine metabolic process (GO:0006573)3.79961234
42CTP metabolic process (GO:0046036)3.79897146
43CTP biosynthetic process (GO:0006241)3.79897146
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70835953
45pyrimidine nucleoside salvage (GO:0043097)3.69578528
46pyrimidine-containing compound salvage (GO:0008655)3.69578528
47regulation of steroid hormone secretion (GO:2000831)3.63498480
48regulation of appetite (GO:0032098)3.63158691
49ribonucleoprotein complex biogenesis (GO:0022613)3.59615044
50skeletal muscle tissue regeneration (GO:0043403)3.59001187
51fatty acid elongation (GO:0030497)3.53146475
52oxygen transport (GO:0015671)3.46806777
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.41765938
54RNA catabolic process (GO:0006401)3.37900053
55metallo-sulfur cluster assembly (GO:0031163)3.37266866
56iron-sulfur cluster assembly (GO:0016226)3.37266866
57phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.36877884
58regulation of icosanoid secretion (GO:0032303)3.36844979
59phosphatidylinositol acyl-chain remodeling (GO:0036149)3.25609826
60negative regulation of cholesterol transport (GO:0032375)3.22461321
61negative regulation of sterol transport (GO:0032372)3.22461321
62negative regulation of gene silencing (GO:0060969)3.11704957
63pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11550994
64pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.11437514
65positive regulation of lipid storage (GO:0010884)3.09419698
66heart trabecula morphogenesis (GO:0061384)3.09344581
67phosphatidylserine acyl-chain remodeling (GO:0036150)3.08225381
68chaperone-mediated protein transport (GO:0072321)3.05276713
69cellular component biogenesis (GO:0044085)3.03345196
70establishment of protein localization to membrane (GO:0090150)3.01152363
71pyrimidine nucleotide catabolic process (GO:0006244)2.99779744
72ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97228549
73pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96479747
74pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.96394332
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.95756304
76base-excision repair, AP site formation (GO:0006285)2.95168446
77gas transport (GO:0015669)2.91351199
78positive regulation of muscle cell apoptotic process (GO:0010661)2.87588784
79positive regulation of respiratory burst (GO:0060267)2.87120470
80pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.85387155
81UMP metabolic process (GO:0046049)2.85387155
82pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.85387155
83UMP biosynthetic process (GO:0006222)2.85387155
84middle ear morphogenesis (GO:0042474)2.83443289
85protein targeting (GO:0006605)2.83059760
86lysosome localization (GO:0032418)2.82636690
87cellular response to dexamethasone stimulus (GO:0071549)2.80148928
88pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.79686383
89protein neddylation (GO:0045116)2.79337608
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.78518033
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76499647
92ATP biosynthetic process (GO:0006754)2.76131890
93regulation of antigen processing and presentation (GO:0002577)2.76113555
94purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76026315
95GTP biosynthetic process (GO:0006183)2.75691993
96myoblast migration (GO:0051451)2.75540623
97establishment of protein localization to organelle (GO:0072594)2.75204185
98water-soluble vitamin biosynthetic process (GO:0042364)2.72560846
99synaptic transmission, cholinergic (GO:0007271)2.72145119
100regulation of smooth muscle cell apoptotic process (GO:0034391)2.71266396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.61478753
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80812954
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25716985
4EZH2_22144423_ChIP-Seq_EOC_Human2.71000178
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69279565
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.64426214
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.63064440
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.16696549
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11981874
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11901557
11VDR_22108803_ChIP-Seq_LS180_Human2.11119961
12ZNF274_21170338_ChIP-Seq_K562_Hela2.10705367
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07102230
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01688262
15STAT1_20625510_ChIP-Seq_HELA_Human1.88918997
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.86567961
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84018533
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.83663832
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.81852934
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.79610071
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.74562899
22HTT_18923047_ChIP-ChIP_STHdh_Human1.71400680
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62515101
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.62366275
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59983204
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59383977
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.58756092
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56805878
29POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56691305
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54942196
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52710524
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.52468907
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52239824
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49953399
35BCL6_27268052_Chip-Seq_Bcells_Human1.49139789
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47244971
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45785586
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43403986
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41954640
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41954640
41CTCF_20526341_ChIP-Seq_ESCs_Human1.41894096
42RNF2_27304074_Chip-Seq_NSC_Mouse1.39414360
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.39120884
44FOXH1_21741376_ChIP-Seq_ESCs_Human1.38062865
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35833165
46E2F1_20622854_ChIP-Seq_HELA_Human1.35686973
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32597348
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32450419
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30651171
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29702369
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26211391
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25774042
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.24911946
54RBPJ_21746931_ChIP-Seq_IB4_Human1.24465665
55NCOR_22424771_ChIP-Seq_293T_Human1.22389609
56NANOG_20526341_ChIP-Seq_ESCs_Human1.22228460
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20735871
58XRN2_22483619_ChIP-Seq_HELA_Human1.20134965
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19299341
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.18327139
61TP53_22573176_ChIP-Seq_HFKS_Human1.17603945
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15945615
63GATA6_21074721_ChIP-Seq_CACO-2_Human1.12650667
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11764764
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11652058
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.11258544
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11182365
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.10760426
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10755667
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10559869
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10247940
72FUS_26573619_Chip-Seq_HEK293_Human1.09585298
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08876831
74ERA_21632823_ChIP-Seq_H3396_Human1.08394993
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08392878
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08308956
77RUNX_20019798_ChIP-Seq_JUKART_Human1.07023371
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.05494390
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04840939
80TAF2_19829295_ChIP-Seq_ESCs_Human1.03319687
81REST_21632747_ChIP-Seq_MESCs_Mouse1.00838147
82MYC_19829295_ChIP-Seq_ESCs_Human1.00620237
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.98857402
84MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97809900
85AR_20517297_ChIP-Seq_VCAP_Human0.97263957
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95925132
87CTCF_27219007_Chip-Seq_Bcells_Human0.95795213
88SA1_27219007_Chip-Seq_Bcells_Human0.95624462
89VDR_23849224_ChIP-Seq_CD4+_Human0.93446617
90SPI1_20517297_ChIP-Seq_HL60_Human0.92795026
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92734488
92SOX2_21211035_ChIP-Seq_LN229_Human0.91634003
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91217968
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90810608
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.90810608
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90788505
97BCOR_27268052_Chip-Seq_Bcells_Human0.90465746
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90161086
99ELK1_19687146_ChIP-ChIP_HELA_Human0.89348291
100PHF8_20622853_ChIP-Seq_HELA_Human0.87124665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.72605750
2MP0002102_abnormal_ear_morphology4.53741935
3MP0003646_muscle_fatigue3.31131908
4MP0008789_abnormal_olfactory_epithelium3.20490760
5MP0010386_abnormal_urinary_bladder3.19828693
6MP0009333_abnormal_splenocyte_physiolog3.13587565
7MP0002909_abnormal_adrenal_gland2.94512804
8MP0002163_abnormal_gland_morphology2.76945513
9MP0006292_abnormal_olfactory_placode2.64368020
10MP0002638_abnormal_pupillary_reflex2.62696070
11MP0001968_abnormal_touch/_nociception2.52727050
12MP0005394_taste/olfaction_phenotype2.45206361
13MP0005499_abnormal_olfactory_system2.45206361
14MP0005671_abnormal_response_to2.28412295
15MP0005503_abnormal_tendon_morphology2.19803243
16MP0000343_altered_response_to2.00471370
17MP0000750_abnormal_muscle_regeneration1.95656732
18MP0000538_abnormal_urinary_bladder1.95380203
19MP0006082_CNS_inflammation1.87976206
20MP0003279_aneurysm1.86848871
21MP0003567_abnormal_fetal_cardiomyocyte1.68966458
22MP0003879_abnormal_hair_cell1.67704646
23MP0004145_abnormal_muscle_electrophysio1.67162562
24MP0004885_abnormal_endolymph1.62540788
25MP0005670_abnormal_white_adipose1.61688998
26MP0001905_abnormal_dopamine_level1.52408050
27MP0004858_abnormal_nervous_system1.51921046
28MP0005275_abnormal_skin_tensile1.48022392
29MP0001188_hyperpigmentation1.45928802
30MP0001790_abnormal_immune_system1.41253564
31MP0005387_immune_system_phenotype1.41253564
32MP0005083_abnormal_biliary_tract1.37509905
33MP0005646_abnormal_pituitary_gland1.36111523
34MP0005379_endocrine/exocrine_gland_phen1.33868252
35MP0002837_dystrophic_cardiac_calcinosis1.32670994
36MP0008875_abnormal_xenobiotic_pharmacok1.30705601
37MP0000049_abnormal_middle_ear1.26481374
38MP0002148_abnormal_hypersensitivity_rea1.22109425
39MP0001348_abnormal_lacrimal_gland1.19671911
40MP0009745_abnormal_behavioral_response1.15054522
41MP0000639_abnormal_adrenal_gland1.13295626
42MP0003436_decreased_susceptibility_to1.13183775
43MP0002234_abnormal_pharynx_morphology1.10975204
44MP0008775_abnormal_heart_ventricle1.09024251
45MP0000631_abnormal_neuroendocrine_gland1.06490327
46MP0002160_abnormal_reproductive_system1.04991626
47MP0005389_reproductive_system_phenotype1.04483629
48MP0004036_abnormal_muscle_relaxation1.03187147
49MP0001986_abnormal_taste_sensitivity1.02320215
50MP0008872_abnormal_physiological_respon1.01239898
51MP0008873_increased_physiological_sensi0.99582814
52MP0003786_premature_aging0.97718964
53MP0009785_altered_susceptibility_to0.97560558
54MP0003638_abnormal_response/metabolism_0.95550647
55MP0002095_abnormal_skin_pigmentation0.93959073
56MP0003195_calcinosis0.92679460
57MP0001800_abnormal_humoral_immune0.91536686
58MP0002938_white_spotting0.91356276
59MP0003763_abnormal_thymus_physiology0.89707048
60MP0002277_abnormal_respiratory_mucosa0.88929456
61MP0001919_abnormal_reproductive_system0.88806650
62MP0009250_abnormal_appendicular_skeleto0.88323249
63MP0002723_abnormal_immune_serum0.88104671
64MP0003136_yellow_coat_color0.87593012
65MP0005360_urolithiasis0.79919978
66MP0005623_abnormal_meninges_morphology0.79672192
67MP0002233_abnormal_nose_morphology0.79346303
68MP0000685_abnormal_immune_system0.77760349
69MP0010329_abnormal_lipoprotein_level0.77359234
70MP0000026_abnormal_inner_ear0.77299137
71MP0006072_abnormal_retinal_apoptosis0.75866316
72MP0000230_abnormal_systemic_arterial0.74013260
73MP0003878_abnormal_ear_physiology0.73572041
74MP0005377_hearing/vestibular/ear_phenot0.73572041
75MP0002108_abnormal_muscle_morphology0.73547701
76MP0005551_abnormal_eye_electrophysiolog0.70179358
77MP0009384_cardiac_valve_regurgitation0.69301230
78MP0001915_intracranial_hemorrhage0.67737521
79MP0005448_abnormal_energy_balance0.65968263
80MP0005645_abnormal_hypothalamus_physiol0.65370800
81MP0008995_early_reproductive_senescence0.64763176
82MP0001765_abnormal_ion_homeostasis0.64168553
83MP0005409_darkened_coat_color0.63368530
84MP0004142_abnormal_muscle_tone0.63261388
85MP0004484_altered_response_of0.60683308
86MP0000678_abnormal_parathyroid_gland0.58555856
87MP0001664_abnormal_digestion0.58254432
88MP0002452_abnormal_antigen_presenting0.57180495
89MP0005000_abnormal_immune_tolerance0.56871412
90MP0000372_irregular_coat_pigmentation0.56479959
91MP0003011_delayed_dark_adaptation0.56363442
92MP0001835_abnormal_antigen_presentation0.55291440
93MP0002420_abnormal_adaptive_immunity0.55067753
94MP0001346_abnormal_lacrimal_gland0.54542608
95MP0005166_decreased_susceptibility_to0.54329573
96MP0001819_abnormal_immune_cell0.53475820
97MP0001845_abnormal_inflammatory_respons0.53325137
98MP0005085_abnormal_gallbladder_physiolo0.52856583
99MP0001542_abnormal_bone_strength0.52330576
100MP0006054_spinal_hemorrhage0.51944267

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.20864266
2Decreased activity of mitochondrial respiratory chain (HP:0008972)5.69141913
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.69141913
4Abnormal number of erythroid precursors (HP:0012131)4.40796889
5Aplasia/Hypoplasia of the sacrum (HP:0008517)4.29106419
6Abnormality of cells of the erythroid lineage (HP:0012130)4.28902727
7Increased muscle lipid content (HP:0009058)4.27870647
8Increased intramyocellular lipid droplets (HP:0012240)4.26299925
9Symptomatic seizures (HP:0011145)4.08936306
10Pallor (HP:0000980)4.03770520
11Hyperlipoproteinemia (HP:0010980)3.95381530
12Abnormal respiratory motile cilium morphology (HP:0005938)3.89041199
13Abnormal respiratory epithelium morphology (HP:0012253)3.89041199
14Abnormal ciliary motility (HP:0012262)3.84248611
15Macrocytic anemia (HP:0001972)3.71826821
16Abnormal rod and cone electroretinograms (HP:0008323)3.47005491
17Lipid accumulation in hepatocytes (HP:0006561)3.45431511
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.44934504
19Asplenia (HP:0001746)3.22795958
20Abnormal respiratory motile cilium physiology (HP:0012261)3.21557027
21Rectal prolapse (HP:0002035)3.20926333
22Difficulty running (HP:0009046)3.17902048
23Increased hepatocellular lipid droplets (HP:0006565)3.14322259
24Self-mutilation (HP:0000742)3.13122934
25Acute necrotizing encephalopathy (HP:0006965)3.10608624
26Chronic sinusitis (HP:0011109)3.03415186
27Aplasia/Hypoplasia of the spleen (HP:0010451)3.03114762
28Renal Fanconi syndrome (HP:0001994)2.94725650
29Congenital stationary night blindness (HP:0007642)2.78684511
30Pendular nystagmus (HP:0012043)2.75914831
31Rhinitis (HP:0012384)2.74123566
32Abnormal mitochondria in muscle tissue (HP:0008316)2.72059635
33Abnormal pupillary function (HP:0007686)2.70051239
34Acute encephalopathy (HP:0006846)2.69659255
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65694792
36Mitochondrial inheritance (HP:0001427)2.59324163
37Progressive macrocephaly (HP:0004481)2.57983381
38Maternal diabetes (HP:0009800)2.50439817
39Neoplasm of head and neck (HP:0012288)2.42573403
40Esophageal neoplasm (HP:0100751)2.42573403
41Hyperglycinemia (HP:0002154)2.35283642
423-Methylglutaconic aciduria (HP:0003535)2.34529682
43Exertional dyspnea (HP:0002875)2.33753081
44Abnormal hemoglobin (HP:0011902)2.30343150
45Abnormality of the middle phalanges of the toes (HP:0010183)2.28105476
46Hypoplasia of the uterus (HP:0000013)2.25059802
47Exercise intolerance (HP:0003546)2.21226785
48Concave nail (HP:0001598)2.20506941
49Symphalangism affecting the phalanges of the hand (HP:0009773)2.18696720
50Abnormality of the musculature of the hand (HP:0001421)2.17549713
51Scotoma (HP:0000575)2.10549021
52Abnormal drinking behavior (HP:0030082)2.10323066
53Polydipsia (HP:0001959)2.10323066
54Abnormality of the columella (HP:0009929)2.09093130
55Increased CSF lactate (HP:0002490)2.05124269
56Decreased central vision (HP:0007663)2.04113679
57Reticulocytopenia (HP:0001896)2.02951668
58Increased corneal curvature (HP:0100692)2.01147823
59Keratoconus (HP:0000563)2.01147823
60Acanthocytosis (HP:0001927)1.96872894
61Respiratory difficulties (HP:0002880)1.96576083
62Polyuria (HP:0000103)1.96216608
63Attenuation of retinal blood vessels (HP:0007843)1.95505538
64Abnormality of renal resorption (HP:0011038)1.95399142
65Bony spicule pigmentary retinopathy (HP:0007737)1.94579544
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94307795
67Short femoral neck (HP:0100864)1.93842988
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91160153
69Episodic fever (HP:0001954)1.89589390
70Gastrointestinal infarctions (HP:0005244)1.88447989
71Hyperthyroidism (HP:0000836)1.88254245
72Type 2 muscle fiber atrophy (HP:0003554)1.86750542
73Bronchiectasis (HP:0002110)1.85732018
74Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85261981
75Abnormality of the phalanges of the 5th finger (HP:0004213)1.84801363
76Tubular atrophy (HP:0000092)1.82496267
77Abnormality of the heme biosynthetic pathway (HP:0010472)1.80352305
78Hypoplasia of the radius (HP:0002984)1.80008150
79Progressive microcephaly (HP:0000253)1.79056991
80Broad distal phalanx of finger (HP:0009836)1.77204478
81Dyskinesia (HP:0100660)1.75821519
82Aplasia/hypoplasia of the uterus (HP:0008684)1.72210402
83Poor suck (HP:0002033)1.71848722
84Abnormal urine output (HP:0012590)1.70608793
85Lactic acidosis (HP:0003128)1.70449453
86Anencephaly (HP:0002323)1.70062816
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.67497072
88Enlarged kidneys (HP:0000105)1.65903787
89Hyperphosphaturia (HP:0003109)1.63714931
90Submucous cleft hard palate (HP:0000176)1.63434416
91Abnormality of the proximal phalanges of the hand (HP:0009834)1.63283285
92Carpal bone hypoplasia (HP:0001498)1.62884672
93Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.62579890
94Mesomelia (HP:0003027)1.61737414
95Abnormality of urine glucose concentration (HP:0011016)1.60741316
96Glycosuria (HP:0003076)1.60741316
97Hip dysplasia (HP:0001385)1.59367785
98Muscle fiber atrophy (HP:0100295)1.58502652
99Abnormality of the 4th metacarpal (HP:0010012)1.56918681
100Hypoplasia of the ulna (HP:0003022)1.56680405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.52950793
2AKT34.34091815
3ERN13.87800585
4ADRBK23.79350848
5IRAK43.33790373
6TLK13.05624511
7MAP2K22.99228434
8ABL22.62843856
9LRRK22.16726342
10TAF12.11527142
11ILK2.08488977
12DYRK1A2.07478022
13WNK42.04667606
14STK391.94704818
15NTRK31.84695875
16MAP2K11.79066892
17MARK31.78180844
18PIK3CG1.71467638
19PRKD21.65358969
20NEK11.54624056
21BUB11.47971835
22LIMK11.41987607
23GRK11.36187196
24ADRBK11.35480965
25RPS6KA51.31203781
26DYRK21.26005314
27NEK91.25456082
28BRAF1.25390257
29MAP3K41.22845542
30TNK21.22492862
31WNK31.22003057
32NLK1.20114930
33INSRR1.18259367
34EIF2AK11.16835276
35MAP4K11.13794227
36TEC1.11605494
37OBSCN1.09195598
38ERBB21.08615924
39MAP4K21.00633664
40SGK31.00356378
41SGK2230.97802741
42SGK4940.97802741
43IKBKE0.95407303
44MUSK0.93314784
45PDK20.85020643
46CSNK2A20.83948410
47SGK20.81595184
48CSNK2A10.79984709
49PIM10.77491392
50CLK10.77183363
51PTK20.72463461
52BCKDK0.72103341
53PRKCG0.72038691
54PRKACA0.70407074
55TIE10.69975208
56CDC42BPA0.68668540
57MKNK20.67421881
58ABL10.66322932
59MAPK130.64355131
60PLK40.60977690
61FRK0.57559603
62PRKCQ0.57287893
63LYN0.55673191
64PAK10.55467186
65MAP2K60.54820406
66GRK70.54297414
67HCK0.53307820
68DYRK30.52650609
69PRKCI0.50751307
70IKBKB0.50473903
71STK110.49116703
72PIM20.49035884
73FGFR20.47125638
74PDPK10.46630718
75CAMK2A0.45492280
76PRKCA0.45143820
77TXK0.45089602
78PRKCZ0.44080130
79BMPR1B0.43402750
80MAPK150.40737025
81PRKG10.39536897
82ERBB40.38860002
83SYK0.38047500
84TGFBR10.37959816
85BTK0.37342828
86RPS6KA60.37158883
87MAPK30.37005498
88PRKACG0.36076523
89AURKB0.35926559
90BMPR20.32450016
91LCK0.32236080
92MYLK0.31926627
93MAP3K110.31286649
94KDR0.30961575
95RIPK40.30961357
96EPHA40.30655767
97PKN10.29714103
98CAMK2G0.28705988
99EGFR0.27948904
100CSNK1E0.26590354

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.72781808
2Sulfur relay system_Homo sapiens_hsa041226.41266111
3Asthma_Homo sapiens_hsa053102.92555288
4Allograft rejection_Homo sapiens_hsa053302.50169601
5Oxidative phosphorylation_Homo sapiens_hsa001902.49951944
6Graft-versus-host disease_Homo sapiens_hsa053322.44173781
7Autoimmune thyroid disease_Homo sapiens_hsa053202.42706429
8Linoleic acid metabolism_Homo sapiens_hsa005912.24739078
9Parkinsons disease_Homo sapiens_hsa050122.23124512
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.20202642
11Fat digestion and absorption_Homo sapiens_hsa049751.86613650
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82210266
13Type I diabetes mellitus_Homo sapiens_hsa049401.79525709
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79387481
15Alzheimers disease_Homo sapiens_hsa050101.68094255
16Primary immunodeficiency_Homo sapiens_hsa053401.62539152
17Staphylococcus aureus infection_Homo sapiens_hsa051501.56669912
18Viral myocarditis_Homo sapiens_hsa054161.48987629
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46843906
20Huntingtons disease_Homo sapiens_hsa050161.46499224
21Phototransduction_Homo sapiens_hsa047441.42798181
22Arachidonic acid metabolism_Homo sapiens_hsa005901.39265712
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33879140
24Systemic lupus erythematosus_Homo sapiens_hsa053221.26490554
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17017665
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16879546
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.14908799
28Regulation of autophagy_Homo sapiens_hsa041401.10766093
29Pyrimidine metabolism_Homo sapiens_hsa002401.10286097
30Antigen processing and presentation_Homo sapiens_hsa046121.07890934
31Leishmaniasis_Homo sapiens_hsa051401.06538784
32Hematopoietic cell lineage_Homo sapiens_hsa046401.05004557
33Olfactory transduction_Homo sapiens_hsa047401.01076696
34Cardiac muscle contraction_Homo sapiens_hsa042601.00264983
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98116391
36DNA replication_Homo sapiens_hsa030300.94863688
37Nicotine addiction_Homo sapiens_hsa050330.91385448
38Rheumatoid arthritis_Homo sapiens_hsa053230.87108756
39Fatty acid elongation_Homo sapiens_hsa000620.81070860
40Caffeine metabolism_Homo sapiens_hsa002320.75692381
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72662649
42Ether lipid metabolism_Homo sapiens_hsa005650.70696090
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.68306249
44Sulfur metabolism_Homo sapiens_hsa009200.68191224
45Nitrogen metabolism_Homo sapiens_hsa009100.67969332
46Chemical carcinogenesis_Homo sapiens_hsa052040.65752894
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65229601
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64982655
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63357151
50Toxoplasmosis_Homo sapiens_hsa051450.63280408
51RNA polymerase_Homo sapiens_hsa030200.61572860
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61359225
53Retinol metabolism_Homo sapiens_hsa008300.59527836
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54694694
55Malaria_Homo sapiens_hsa051440.54688594
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.53707045
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47936060
58Morphine addiction_Homo sapiens_hsa050320.47343905
59Sphingolipid metabolism_Homo sapiens_hsa006000.47117273
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46807471
61Tuberculosis_Homo sapiens_hsa051520.45843414
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44060427
63Melanoma_Homo sapiens_hsa052180.44056499
64Influenza A_Homo sapiens_hsa051640.41642211
65Purine metabolism_Homo sapiens_hsa002300.40857400
66Pertussis_Homo sapiens_hsa051330.40245718
67Butanoate metabolism_Homo sapiens_hsa006500.36720205
68p53 signaling pathway_Homo sapiens_hsa041150.36524330
69Tyrosine metabolism_Homo sapiens_hsa003500.35532475
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.35323422
71Serotonergic synapse_Homo sapiens_hsa047260.34502425
72Pancreatic secretion_Homo sapiens_hsa049720.33864882
73Metabolic pathways_Homo sapiens_hsa011000.31738972
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.31101494
75Vitamin B6 metabolism_Homo sapiens_hsa007500.30998639
76Apoptosis_Homo sapiens_hsa042100.30994932
77Proteasome_Homo sapiens_hsa030500.29145171
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29061229
79One carbon pool by folate_Homo sapiens_hsa006700.28230730
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25735473
81Taste transduction_Homo sapiens_hsa047420.23830981
82Fanconi anemia pathway_Homo sapiens_hsa034600.23789688
83Protein digestion and absorption_Homo sapiens_hsa049740.22887329
84Homologous recombination_Homo sapiens_hsa034400.22582499
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20116898
86Chemokine signaling pathway_Homo sapiens_hsa040620.19830697
87Ovarian steroidogenesis_Homo sapiens_hsa049130.19656341
88Complement and coagulation cascades_Homo sapiens_hsa046100.18467678
89Circadian entrainment_Homo sapiens_hsa047130.18007795
90Melanogenesis_Homo sapiens_hsa049160.16896955
91Selenocompound metabolism_Homo sapiens_hsa004500.16871261
92Calcium signaling pathway_Homo sapiens_hsa040200.16846961
93Legionellosis_Homo sapiens_hsa051340.15515236
94African trypanosomiasis_Homo sapiens_hsa051430.15234291
95Tryptophan metabolism_Homo sapiens_hsa003800.13573210
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13253523
97Mismatch repair_Homo sapiens_hsa034300.12731330
98Measles_Homo sapiens_hsa051620.12170763
99Alcoholism_Homo sapiens_hsa050340.09390982
100Glutathione metabolism_Homo sapiens_hsa004800.09028977

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