RPS13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)9.31080208
2* translational termination (GO:0006415)8.94506709
3ribosomal small subunit assembly (GO:0000028)8.70991759
4ribosomal small subunit biogenesis (GO:0042274)8.37869998
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.69564458
6* translational elongation (GO:0006414)7.61119318
7* cotranslational protein targeting to membrane (GO:0006613)7.55750065
8* protein targeting to ER (GO:0045047)7.54097702
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.20797522
10* protein localization to endoplasmic reticulum (GO:0070972)7.05222896
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.00480519
12* viral life cycle (GO:0019058)6.93817826
13* cellular protein complex disassembly (GO:0043624)6.90273804
14maturation of SSU-rRNA (GO:0030490)6.88730644
15* translational initiation (GO:0006413)6.60964829
16* protein complex disassembly (GO:0043241)6.05472666
17ribosomal large subunit biogenesis (GO:0042273)5.80956869
18* macromolecular complex disassembly (GO:0032984)5.64612968
19* nuclear-transcribed mRNA catabolic process (GO:0000956)5.07309256
20* protein targeting to membrane (GO:0006612)4.99004896
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97503200
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.88788845
23respiratory electron transport chain (GO:0022904)4.88719638
24chaperone-mediated protein transport (GO:0072321)4.85138815
25* mRNA catabolic process (GO:0006402)4.82381486
26* translation (GO:0006412)4.78461926
27electron transport chain (GO:0022900)4.76915996
28ribonucleoprotein complex biogenesis (GO:0022613)4.64008725
29* RNA catabolic process (GO:0006401)4.50062056
30formation of translation preinitiation complex (GO:0001731)4.09618274
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.04340779
32NADH dehydrogenase complex assembly (GO:0010257)4.04340779
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.04340779
34DNA deamination (GO:0045006)3.98068816
35protein complex biogenesis (GO:0070271)3.97314463
36mitochondrial respiratory chain complex assembly (GO:0033108)3.83413980
37rRNA processing (GO:0006364)3.71436372
38telomere maintenance via semi-conservative replication (GO:0032201)3.70223161
39DNA strand elongation involved in DNA replication (GO:0006271)3.68525009
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67430386
41protein neddylation (GO:0045116)3.59771654
42oxidative phosphorylation (GO:0006119)3.59291164
43rRNA metabolic process (GO:0016072)3.57489094
44cellular component biogenesis (GO:0044085)3.51114187
45DNA strand elongation (GO:0022616)3.49752716
46ATP biosynthetic process (GO:0006754)3.46063179
47regulation of mitochondrial translation (GO:0070129)3.34104283
48* establishment of protein localization to membrane (GO:0090150)3.33537036
49protein targeting to mitochondrion (GO:0006626)3.31611955
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31467108
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.29164090
52telomere maintenance via recombination (GO:0000722)3.19107074
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18121965
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18121965
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17940827
56pyrimidine nucleotide catabolic process (GO:0006244)3.14579730
57establishment of integrated proviral latency (GO:0075713)3.11903347
58establishment of protein localization to mitochondrion (GO:0072655)3.11761415
59* establishment of protein localization to organelle (GO:0072594)3.10861878
60ATP synthesis coupled proton transport (GO:0015986)3.09685821
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09685821
62* protein targeting (GO:0006605)3.09598026
63spliceosomal snRNP assembly (GO:0000387)3.09204801
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.07319547
65DNA unwinding involved in DNA replication (GO:0006268)3.07155554
66protein localization to mitochondrion (GO:0070585)3.06249834
67DNA replication initiation (GO:0006270)3.05513895
68hydrogen ion transmembrane transport (GO:1902600)3.02632252
69inner mitochondrial membrane organization (GO:0007007)2.98096340
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.94211487
71termination of RNA polymerase III transcription (GO:0006386)2.94211487
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94198013
73mitotic recombination (GO:0006312)2.92216560
74aerobic respiration (GO:0009060)2.90577663
75spliceosomal complex assembly (GO:0000245)2.90248582
76rRNA modification (GO:0000154)2.88322651
77intracellular protein transmembrane import (GO:0044743)2.85347285
78GTP biosynthetic process (GO:0006183)2.85246218
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84800012
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.83603249
81telomere maintenance via telomere lengthening (GO:0010833)2.83087190
82ribosome biogenesis (GO:0042254)2.80253349
83proteasome assembly (GO:0043248)2.79128693
84* protein localization to organelle (GO:0033365)2.78619088
85pseudouridine synthesis (GO:0001522)2.77423632
86base-excision repair, AP site formation (GO:0006285)2.77329591
87ncRNA 3-end processing (GO:0043628)2.73570234
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73525921
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73414575
90nucleoside triphosphate biosynthetic process (GO:0009142)2.72722005
91mitochondrial transport (GO:0006839)2.72148079
92transcription-coupled nucleotide-excision repair (GO:0006283)2.71929166
93DNA damage response, detection of DNA damage (GO:0042769)2.71865575
94deoxyribose phosphate catabolic process (GO:0046386)2.71609269
95histone mRNA metabolic process (GO:0008334)2.70799125
96purine nucleoside monophosphate biosynthetic process (GO:0009127)2.70595058
97purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.70595058
98deoxyribonucleotide catabolic process (GO:0009264)2.69901311
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68707286
100* negative regulation of RNA splicing (GO:0033119)2.67295179
101termination of RNA polymerase I transcription (GO:0006363)2.65261156
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63885794
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63502108
104negative regulation of ligase activity (GO:0051352)2.63502108
105termination of RNA polymerase II transcription (GO:0006369)2.61466150
106pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60870282
107respiratory chain complex IV assembly (GO:0008535)2.60847848
108deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60005885
109ncRNA metabolic process (GO:0034660)2.59955205
110regulation of protein heterodimerization activity (GO:0043497)2.59498634
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59495581
112ncRNA processing (GO:0034470)2.59487214
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.59019622
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58503420
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57596063
116establishment of viral latency (GO:0019043)2.56326599
117antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56129253
118* gene expression (GO:0010467)2.55548216
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54344645
120mRNA splicing, via spliceosome (GO:0000398)2.54344645
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54294984
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54294984
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53966813
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53966813
125RNA splicing, via transesterification reactions (GO:0000375)2.53959369
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53731085
127DNA-templated transcription, termination (GO:0006353)2.53355416
128CENP-A containing nucleosome assembly (GO:0034080)2.53047212
129* protein localization to membrane (GO:0072657)2.51975054
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51852815
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.50589670
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.50589670
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.50589670
1347-methylguanosine mRNA capping (GO:0006370)2.50500421
135ribonucleoprotein complex assembly (GO:0022618)2.48724152
1367-methylguanosine RNA capping (GO:0009452)2.47175044
137RNA capping (GO:0036260)2.47175044
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46823166
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.46823166
140DNA replication checkpoint (GO:0000076)2.43737156
141protein localization to kinetochore (GO:0034501)2.42931404
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.42890887
143chromatin remodeling at centromere (GO:0031055)2.42233178
144UTP biosynthetic process (GO:0006228)2.41302912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03198975
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.57525372
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05247224
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.97530468
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.34964146
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.28497378
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26015216
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.97316211
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96658733
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84101865
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81898171
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69530880
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67228014
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65591472
15XRN2_22483619_ChIP-Seq_HELA_Human2.64924383
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61217745
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54822707
18VDR_23849224_ChIP-Seq_CD4+_Human2.47328277
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47229178
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42192684
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.41793209
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36957836
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26829143
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22164188
25* TTF2_22483619_ChIP-Seq_HELA_Human2.16287160
26FOXP3_21729870_ChIP-Seq_TREG_Human2.11606238
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08117874
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07278815
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04726362
30DCP1A_22483619_ChIP-Seq_HELA_Human2.04153953
31ELK1_19687146_ChIP-ChIP_HELA_Human2.03466989
32MYC_22102868_ChIP-Seq_BL_Human2.01590816
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00633069
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97330922
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89666782
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81030585
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78048870
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71028944
39CIITA_25753668_ChIP-Seq_RAJI_Human1.70725326
40* GABP_19822575_ChIP-Seq_HepG2_Human1.70220217
41VDR_21846776_ChIP-Seq_THP-1_Human1.67580003
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63182885
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60201136
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59473980
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58693027
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.58658277
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52703189
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51964306
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49822427
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49188402
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.48006897
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44767935
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44072776
54* SPI1_23547873_ChIP-Seq_NB4_Human1.42507627
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.41326780
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.41260841
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.38997651
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38143419
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37615018
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34254220
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.34092500
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27036548
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26032456
64MYC_18940864_ChIP-ChIP_HL60_Human1.23970595
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.22626037
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.21957331
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21955635
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21412037
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20671437
70KDM5A_27292631_Chip-Seq_BREAST_Human1.20304754
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19552779
72SCL_19346495_ChIP-Seq_HPC-7_Human1.18290554
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17298735
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16288040
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16192776
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15648961
77AR_21909140_ChIP-Seq_LNCAP_Human1.15222334
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14158941
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13673413
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12727949
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.12207202
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11415042
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11266034
84MAF_26560356_Chip-Seq_TH1_Human1.10683556
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07572587
86UTX_26944678_Chip-Seq_JUKART_Human1.06476301
87MYB_26560356_Chip-Seq_TH2_Human1.06197085
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05151545
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03708400
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01880952
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01206832
92MAF_26560356_Chip-Seq_TH2_Human1.00778708
93IRF1_19129219_ChIP-ChIP_H3396_Human1.00775072
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00213940
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99065443
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98990096
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98237506
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97991871
99TFEB_21752829_ChIP-Seq_HELA_Human0.96512396
100VDR_24763502_ChIP-Seq_THP-1_Human0.95866238
101MYB_26560356_Chip-Seq_TH1_Human0.94583643
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94452238
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93210235
104KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92111464
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91803534
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90904206
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.90874126
108* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89899322
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89868331
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89496556
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88996613
112EWS_26573619_Chip-Seq_HEK293_Human0.83263892
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81363751
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79987210
115* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77379501
116* NANOG_16153702_ChIP-ChIP_HESCs_Human0.77032784
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74524878
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74524878
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74524878
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72298266
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71986951
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.71934876
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70220917
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69353281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.74725167
2MP0003693_abnormal_embryo_hatching3.73378635
3MP0004957_abnormal_blastocyst_morpholog3.19238763
4MP0002396_abnormal_hematopoietic_system2.81920308
5MP0010094_abnormal_chromosome_stability2.75743829
6MP0003077_abnormal_cell_cycle2.72309650
7MP0003763_abnormal_thymus_physiology2.61732552
8MP0008057_abnormal_DNA_replication2.47060289
9MP0003111_abnormal_nucleus_morphology2.41687107
10MP0003806_abnormal_nucleotide_metabolis2.40925024
11MP0001835_abnormal_antigen_presentation2.33728035
12MP0009333_abnormal_splenocyte_physiolog2.20944824
13MP0008007_abnormal_cellular_replicative2.18073415
14MP0008058_abnormal_DNA_repair2.08145767
15MP0003718_maternal_effect2.01599178
16MP0000685_abnormal_immune_system2.01585379
17MP0000490_abnormal_crypts_of2.00747338
18MP0005671_abnormal_response_to1.97462953
19MP0001800_abnormal_humoral_immune1.94973238
20MP0002398_abnormal_bone_marrow1.93859417
21MP0008789_abnormal_olfactory_epithelium1.91156284
22MP0004808_abnormal_hematopoietic_stem1.90532411
23MP0001529_abnormal_vocalization1.80279786
24MP0005174_abnormal_tail_pigmentation1.77642856
25MP0003136_yellow_coat_color1.75890252
26MP0006072_abnormal_retinal_apoptosis1.73154736
27MP0003786_premature_aging1.72880937
28MP0008932_abnormal_embryonic_tissue1.72818008
29MP0000703_abnormal_thymus_morphology1.70668395
30MP0002722_abnormal_immune_system1.70141642
31MP0002420_abnormal_adaptive_immunity1.67478927
32MP0002160_abnormal_reproductive_system1.65147213
33MP0002452_abnormal_antigen_presenting1.64581554
34MP0001819_abnormal_immune_cell1.64259327
35MP0000689_abnormal_spleen_morphology1.62075897
36MP0001293_anophthalmia1.59676204
37MP0005000_abnormal_immune_tolerance1.58990688
38MP0003436_decreased_susceptibility_to1.58214382
39MP0002166_altered_tumor_susceptibility1.58005591
40MP0006054_spinal_hemorrhage1.57763374
41MP0002723_abnormal_immune_serum1.57709951
42MP0009785_altered_susceptibility_to1.56749895
43MP0000716_abnormal_immune_system1.56734339
44MP0002429_abnormal_blood_cell1.50904215
45MP0000465_gastrointestinal_hemorrhage1.49412873
46MP0005025_abnormal_response_to1.48124240
47MP0004381_abnormal_hair_follicle1.45648302
48MP0004142_abnormal_muscle_tone1.45607516
49MP0002405_respiratory_system_inflammati1.44231349
50MP0001853_heart_inflammation1.44171683
51MP0002132_abnormal_respiratory_system1.44131621
52MP0002148_abnormal_hypersensitivity_rea1.42902667
53MP0000350_abnormal_cell_proliferation1.42039569
54MP0006035_abnormal_mitochondrial_morpho1.41452457
55MP0005387_immune_system_phenotype1.41391209
56MP0001790_abnormal_immune_system1.41391209
57MP0001545_abnormal_hematopoietic_system1.41351374
58MP0005397_hematopoietic_system_phenotyp1.41351374
59MP0005499_abnormal_olfactory_system1.41135280
60MP0005394_taste/olfaction_phenotype1.41135280
61MP0002095_abnormal_skin_pigmentation1.40316103
62MP0005075_abnormal_melanosome_morpholog1.38438226
63MP0002019_abnormal_tumor_incidence1.38116497
64MP0008877_abnormal_DNA_methylation1.36991158
65MP0002210_abnormal_sex_determination1.36902604
66MP0002938_white_spotting1.34916467
67MP0002006_tumorigenesis1.30272835
68MP0005389_reproductive_system_phenotype1.29688591
69MP0000049_abnormal_middle_ear1.29038486
70MP0001873_stomach_inflammation1.28295061
71MP0003011_delayed_dark_adaptation1.27174473
72MP0003567_abnormal_fetal_cardiomyocyte1.26249175
73MP0000631_abnormal_neuroendocrine_gland1.25138188
74MP0010155_abnormal_intestine_physiology1.23447885
75MP0009697_abnormal_copulation1.22305404
76MP0001730_embryonic_growth_arrest1.21565863
77MP0000858_altered_metastatic_potential1.21053558
78MP0003866_abnormal_defecation1.19156262
79MP0000313_abnormal_cell_death1.17385461
80MP0005379_endocrine/exocrine_gland_phen1.17339462
81MP0010352_gastrointestinal_tract_polyps1.14639722
82MP0003724_increased_susceptibility_to1.11490498
83MP0001145_abnormal_male_reproductive1.07205487
84MP0002234_abnormal_pharynx_morphology1.03701568
85MP0004147_increased_porphyrin_level1.02289147
86MP0005408_hypopigmentation1.02140552
87MP0001929_abnormal_gametogenesis1.01703918
88MP0000653_abnormal_sex_gland1.01184649
89MP0001286_abnormal_eye_development0.97764729
90MP0002080_prenatal_lethality0.97153561
91MP0002638_abnormal_pupillary_reflex0.96769031
92MP0003123_paternal_imprinting0.95839577
93MP0001764_abnormal_homeostasis0.95608636
94MP0005501_abnormal_skin_physiology0.95245118
95MP0001697_abnormal_embryo_size0.94478184
96MP0005464_abnormal_platelet_physiology0.93423950
97MP0005084_abnormal_gallbladder_morpholo0.92515351
98MP0000566_synostosis0.92148606
99MP0001919_abnormal_reproductive_system0.90485468
100MP0003121_genomic_imprinting0.90263330
101MP0003890_abnormal_embryonic-extraembry0.89350965
102MP0002419_abnormal_innate_immunity0.89288704
103MP0003315_abnormal_perineum_morphology0.89024062
104MP0001119_abnormal_female_reproductive0.88066984
105MP0002822_catalepsy0.87879149
106MP0001845_abnormal_inflammatory_respons0.86811118
107MP0001986_abnormal_taste_sensitivity0.84611466
108MP0002837_dystrophic_cardiac_calcinosis0.84500074
109MP0003303_peritoneal_inflammation0.83656380
110MP0004145_abnormal_muscle_electrophysio0.83519467
111MP0004947_skin_inflammation0.80073751
112MP0002102_abnormal_ear_morphology0.78794051
113MP0010307_abnormal_tumor_latency0.78471825
114MP0001905_abnormal_dopamine_level0.78296720
115MP0001346_abnormal_lacrimal_gland0.77883713
116MP0002653_abnormal_ependyma_morphology0.77375385
117MP0009278_abnormal_bone_marrow0.77128368
118MP0003938_abnormal_ear_development0.76512182
119MP0001672_abnormal_embryogenesis/_devel0.76212452
120MP0005380_embryogenesis_phenotype0.76212452
121MP0006276_abnormal_autonomic_nervous0.76022238
122MP0000372_irregular_coat_pigmentation0.75144044
123MP0010030_abnormal_orbit_morphology0.74490371
124MP0001216_abnormal_epidermal_layer0.74445106
125MP0002933_joint_inflammation0.74110773
126MP0001485_abnormal_pinna_reflex0.72825422
127MP0002085_abnormal_embryonic_tissue0.70614104
128MP0002088_abnormal_embryonic_growth/wei0.69954607
129MP0001881_abnormal_mammary_gland0.69894427
130MP0002163_abnormal_gland_morphology0.69694422
131MP0003984_embryonic_growth_retardation0.69498393
132MP0003186_abnormal_redox_activity0.69064337
133MP0003698_abnormal_male_reproductive0.67455697
134MP0000477_abnormal_intestine_morphology0.66785095
135MP0002086_abnormal_extraembryonic_tissu0.66748373
136MP0004197_abnormal_fetal_growth/weight/0.66464021
137MP0009931_abnormal_skin_appearance0.66149799
138MP0002233_abnormal_nose_morphology0.66117566
139MP0006036_abnormal_mitochondrial_physio0.65100187
140MP0009250_abnormal_appendicular_skeleto0.64112067
141MP0003448_altered_tumor_morphology0.63911831
142MP0002796_impaired_skin_barrier0.63451893
143MP0004133_heterotaxia0.62712171
144MP0005023_abnormal_wound_healing0.61365181
145MP0002277_abnormal_respiratory_mucosa0.61113434
146MP0000358_abnormal_cell_content/0.60706293
147MP0002009_preneoplasia0.60212840
148MP0003941_abnormal_skin_development0.60012564
149MP0006292_abnormal_olfactory_placode0.59186739
150MP0001188_hyperpigmentation0.59059472
151MP0003937_abnormal_limbs/digits/tail_de0.58942916
152MP0005253_abnormal_eye_physiology0.58911117
153MP0008995_early_reproductive_senescence0.58569320
154MP0000750_abnormal_muscle_regeneration0.56428336
155MP0005391_vision/eye_phenotype0.52234151
156MP0005645_abnormal_hypothalamus_physiol0.52132129

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.76807892
2Abnormal number of erythroid precursors (HP:0012131)8.03301720
3Reticulocytopenia (HP:0001896)7.70724435
4Macrocytic anemia (HP:0001972)5.81881631
5Pallor (HP:0000980)5.53776437
6Acute encephalopathy (HP:0006846)4.84220258
7Thrombocytosis (HP:0001894)3.75413594
8Aplastic anemia (HP:0001915)3.55912413
9Cerebral edema (HP:0002181)3.55265940
10IgM deficiency (HP:0002850)3.34337584
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19920257
12Lactic acidosis (HP:0003128)3.00537519
13Increased muscle lipid content (HP:0009058)3.00074176
14Colon cancer (HP:0003003)2.91715263
1511 pairs of ribs (HP:0000878)2.80708702
16Abnormal hemoglobin (HP:0011902)2.79376561
17Elevated erythrocyte sedimentation rate (HP:0003565)2.75056016
18Respiratory failure (HP:0002878)2.74039174
19Exercise intolerance (HP:0003546)2.74011603
20Chronic otitis media (HP:0000389)2.72928519
21Leukodystrophy (HP:0002415)2.66762889
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63886764
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63886764
24Multiple enchondromatosis (HP:0005701)2.62416117
25Increased hepatocellular lipid droplets (HP:0006565)2.62135839
26Oral leukoplakia (HP:0002745)2.57449358
27Abnormality of reticulocytes (HP:0004312)2.57259074
28Depressed nasal ridge (HP:0000457)2.57055657
29Congenital, generalized hypertrichosis (HP:0004540)2.56242812
30Exertional dyspnea (HP:0002875)2.56169860
31Optic disc pallor (HP:0000543)2.56153661
32Absent thumb (HP:0009777)2.55153064
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48076223
34Mitochondrial inheritance (HP:0001427)2.45484458
35Birth length less than 3rd percentile (HP:0003561)2.44620993
36Microvesicular hepatic steatosis (HP:0001414)2.43942353
37Poikiloderma (HP:0001029)2.41875425
38Recurrent bronchitis (HP:0002837)2.41535227
39Acute necrotizing encephalopathy (HP:0006965)2.35763557
40Abnormality of renal resorption (HP:0011038)2.34797081
41Trismus (HP:0000211)2.34551314
42Petechiae (HP:0000967)2.34295418
43Panhypogammaglobulinemia (HP:0003139)2.33696528
44IgG deficiency (HP:0004315)2.32890050
45Septo-optic dysplasia (HP:0100842)2.28330400
46Hepatocellular necrosis (HP:0001404)2.26393528
47Entropion (HP:0000621)2.25004769
48Abnormality of T cells (HP:0002843)2.21569122
49Thick lower lip vermilion (HP:0000179)2.20732555
50Microretrognathia (HP:0000308)2.18013569
51Lipid accumulation in hepatocytes (HP:0006561)2.15904864
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15014683
53Migraine (HP:0002076)2.12054083
54Respiratory difficulties (HP:0002880)2.12039700
55Abnormality of T cell physiology (HP:0011840)2.11503461
56Myelodysplasia (HP:0002863)2.11425406
57Abnormal mitochondria in muscle tissue (HP:0008316)2.10637101
58Increased CSF lactate (HP:0002490)2.07629488
59Lymphoma (HP:0002665)2.06130583
60Rough bone trabeculation (HP:0100670)2.05246366
61Triphalangeal thumb (HP:0001199)2.04532047
62Asplenia (HP:0001746)2.04046125
63Lethargy (HP:0001254)2.03848223
64Abnormality of urine glucose concentration (HP:0011016)2.03502806
65Glycosuria (HP:0003076)2.03502806
66Agammaglobulinemia (HP:0004432)2.03254505
67Recurrent viral infections (HP:0004429)2.03101190
68T lymphocytopenia (HP:0005403)2.02067194
69Glossoptosis (HP:0000162)2.01257937
70Renal Fanconi syndrome (HP:0001994)1.99054387
71Hyperphosphaturia (HP:0003109)1.96640310
72Type I transferrin isoform profile (HP:0003642)1.96293737
73Abnormality of the heme biosynthetic pathway (HP:0010472)1.96015877
74Selective tooth agenesis (HP:0001592)1.93006704
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.91678142
76Stenosis of the external auditory canal (HP:0000402)1.91398050
77Cleft eyelid (HP:0000625)1.90469811
78Abnormality of T cell number (HP:0011839)1.89844862
79Premature graying of hair (HP:0002216)1.89701939
80B lymphocytopenia (HP:0010976)1.89385851
81Abnormality of B cell number (HP:0010975)1.89385851
82Progressive macrocephaly (HP:0004481)1.88614853
83Hypoplasia of the radius (HP:0002984)1.87218595
84Basal cell carcinoma (HP:0002671)1.86815945
85Pancytopenia (HP:0001876)1.86495591
86CNS demyelination (HP:0007305)1.86318664
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.85205694
883-Methylglutaconic aciduria (HP:0003535)1.84463684
89Increased intramyocellular lipid droplets (HP:0012240)1.83562419
90Breast hypoplasia (HP:0003187)1.82833611
91Hepatic necrosis (HP:0002605)1.82513901
92Patellar aplasia (HP:0006443)1.81893401
93Meningitis (HP:0001287)1.81245175
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.79963792
95Abnormal number of incisors (HP:0011064)1.79541250
96Horseshoe kidney (HP:0000085)1.79122828
97Molar tooth sign on MRI (HP:0002419)1.77476155
98Abnormality of midbrain morphology (HP:0002418)1.77476155
99Median cleft lip (HP:0000161)1.77256525
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.77215600
101Carpal bone hypoplasia (HP:0001498)1.76593499
102Muscle fiber atrophy (HP:0100295)1.75280021
103Absent septum pellucidum (HP:0001331)1.74861044
104Nasal polyposis (HP:0100582)1.74851237
105Lymphopenia (HP:0001888)1.74317484
106Abnormality of the preputium (HP:0100587)1.73988141
107Abnormality of DNA repair (HP:0003254)1.73947444
108Meckel diverticulum (HP:0002245)1.73610980
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73406390
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.73226598
111Granulocytopenia (HP:0001913)1.72914085
112Atresia of the external auditory canal (HP:0000413)1.72335316
113Myositis (HP:0100614)1.72280151
114Hyperglycinemia (HP:0002154)1.71640565
115Cellulitis (HP:0100658)1.71379554
116Emotional lability (HP:0000712)1.71035180
117Aplasia/Hypoplasia of the patella (HP:0006498)1.70650328
118Prolonged bleeding time (HP:0003010)1.70291488
119Cellular immunodeficiency (HP:0005374)1.69863927
120Increased serum lactate (HP:0002151)1.68444593
121Degeneration of anterior horn cells (HP:0002398)1.68228153
122Abnormality of the anterior horn cell (HP:0006802)1.68228153
123Chronic obstructive pulmonary disease (HP:0006510)1.67633153
124Obstructive lung disease (HP:0006536)1.67633153
125Sparse eyelashes (HP:0000653)1.67256258
126Abnormality of the ileum (HP:0001549)1.67226375
127Type 2 muscle fiber atrophy (HP:0003554)1.65796002
128Abnormality of placental membranes (HP:0011409)1.65653365
129Amniotic constriction ring (HP:0009775)1.65653365
130X-linked dominant inheritance (HP:0001423)1.64746390
131Neoplasm of the pancreas (HP:0002894)1.64617353
132Woolly hair (HP:0002224)1.64502176
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63555239
134Neutropenia (HP:0001875)1.63147950
135Pancreatic cysts (HP:0001737)1.61188736
136Increased serum pyruvate (HP:0003542)1.61160730
137Partial duplication of thumb phalanx (HP:0009944)1.60133570
138Abnormality of alanine metabolism (HP:0010916)1.56783758
139Hyperalaninemia (HP:0003348)1.56783758
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56783758
141Generalized aminoaciduria (HP:0002909)1.55898110
142Abnormality of the phalanges of the 5th finger (HP:0004213)1.55221486
143Rib fusion (HP:0000902)1.55020180
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54434964
145Short middle phalanx of the 5th finger (HP:0004220)1.53929843
146Chromsome breakage (HP:0040012)1.53652350
147Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52134023
148Abnormal urine phosphate concentration (HP:0012599)1.52068938
149Pancreatic fibrosis (HP:0100732)1.51449228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.17122173
2VRK24.90765502
3BUB13.22284181
4MAP4K12.98115181
5WEE12.96621090
6STK162.40782713
7TLK12.28729723
8LRRK22.23482280
9RPS6KB22.19587880
10EEF2K2.15817557
11EIF2AK12.15806806
12SRPK12.13572799
13PIM22.11553889
14VRK12.06758944
15NEK11.94906228
16CDC71.93471267
17TGFBR11.88675844
18DYRK31.84898308
19MST41.83895002
20PBK1.79553708
21EIF2AK31.73591209
22NUAK11.69428082
23BCKDK1.68897827
24PASK1.59849214
25TAF11.57002839
26TEC1.52574413
27BTK1.50735023
28RPS6KA41.49724326
29MAP3K121.46244186
30KDR1.44297484
31STK101.43168617
32MKNK11.40445376
33MAP3K101.38381580
34FLT31.38345593
35NEK21.37432916
36TXK1.30801381
37CDK71.28154146
38ZAP701.26721585
39TESK21.26249191
40GRK61.24307259
41ACVR1B1.23117526
42TSSK61.22714040
43AURKB1.22051417
44KIT1.20958017
45BRSK21.20099043
46ARAF1.18854032
47PIM11.13609994
48NLK1.09470651
49ILK1.09406649
50BLK1.08328430
51JAK31.01767300
52TYK21.01555812
53SYK0.99842618
54NME10.99759313
55PKN20.97009261
56IRAK40.96937024
57IKBKB0.95680786
58DAPK30.95499906
59CLK10.94722237
60MAP3K80.92417352
61BRAF0.90245775
62PLK30.88687939
63CDK40.88285007
64PLK10.88123497
65MKNK20.86753980
66ATR0.86204689
67CSF1R0.85860902
68CDK190.85347489
69IRAK30.83956421
70CDK80.83925303
71PLK40.83812977
72MAP4K20.83120705
73ITK0.82921417
74PDK20.82694397
75PAK40.81291040
76MAPKAPK30.80062902
77RPS6KA50.77837200
78WNK40.77089076
79LCK0.74486372
80MAP2K30.73927129
81LYN0.72421544
82STK40.72160825
83CSNK2A20.69933204
84TBK10.69730762
85AURKA0.67697169
86MAP3K110.67061618
87ABL20.65729374
88SCYL20.65329753
89IKBKE0.61420270
90GRK10.61304926
91EIF2AK20.61175744
92CSNK2A10.59943820
93MAP3K30.55256180
94CHEK10.53069073
95INSRR0.52402345
96CCNB10.51866156
97BMPR1B0.50258201
98TTK0.49526399
99PAK10.47285324
100CDK30.46518580
101TGFBR20.45071181
102MAP2K20.44829842
103CSNK1E0.42452034
104CHEK20.42267309
105CSNK1G30.41942318
106STK240.40129929
107PAK20.39269979
108TAOK30.39097336
109MAPKAPK50.38781171
110ADRBK20.38086773
111MUSK0.37930197
112WNK30.37585478
113MAPKAPK20.37559768
114MARK30.37303349
115MAPK40.36906162
116TNK20.36833776
117RPS6KA60.36639775
118HCK0.36568614
119RPS6KC10.34866189
120RPS6KL10.34866189
121FES0.34409935
122ZAK0.33920232
123DYRK20.33128894
124ATM0.32030897
125CSNK1G10.31704906
126HIPK20.31580481
127PRKCI0.31115632
128CDK20.30283719
129BRSK10.30073432
130PRKCD0.26486051
131CDK10.26398646
132OBSCN0.25067416
133BMPR20.24517791
134PRKCQ0.24019071
135MAP3K130.23798437
136DAPK10.23492520
137CSNK1G20.21852481

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.13976295
2DNA replication_Homo sapiens_hsa030303.84615550
3RNA polymerase_Homo sapiens_hsa030203.24304781
4Proteasome_Homo sapiens_hsa030503.15004143
5Mismatch repair_Homo sapiens_hsa034303.08474884
6Spliceosome_Homo sapiens_hsa030403.01129648
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44651177
8Nucleotide excision repair_Homo sapiens_hsa034202.33728005
9Base excision repair_Homo sapiens_hsa034102.29893080
10Homologous recombination_Homo sapiens_hsa034402.29268099
11Pyrimidine metabolism_Homo sapiens_hsa002402.27249078
12RNA transport_Homo sapiens_hsa030132.06677566
13Protein export_Homo sapiens_hsa030601.92363537
14Primary immunodeficiency_Homo sapiens_hsa053401.90143081
15Parkinsons disease_Homo sapiens_hsa050121.74237166
16Oxidative phosphorylation_Homo sapiens_hsa001901.73042597
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71254488
18Cell cycle_Homo sapiens_hsa041101.53281244
19One carbon pool by folate_Homo sapiens_hsa006701.51614225
20Non-homologous end-joining_Homo sapiens_hsa034501.51195300
21RNA degradation_Homo sapiens_hsa030181.45216485
22Basal transcription factors_Homo sapiens_hsa030221.42237664
23Fanconi anemia pathway_Homo sapiens_hsa034601.41906387
24Huntingtons disease_Homo sapiens_hsa050161.34303792
25Antigen processing and presentation_Homo sapiens_hsa046121.32006626
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29089657
27p53 signaling pathway_Homo sapiens_hsa041151.18111708
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17700164
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16097464
30Systemic lupus erythematosus_Homo sapiens_hsa053221.11502715
31Herpes simplex infection_Homo sapiens_hsa051681.10916001
32Alzheimers disease_Homo sapiens_hsa050101.04864887
33mRNA surveillance pathway_Homo sapiens_hsa030151.04101819
34Purine metabolism_Homo sapiens_hsa002301.02685800
35Hematopoietic cell lineage_Homo sapiens_hsa046400.98002146
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.93338604
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.90550509
38Measles_Homo sapiens_hsa051620.88930982
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88483294
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85026509
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82711713
42Sulfur relay system_Homo sapiens_hsa041220.78123670
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.78121951
44Allograft rejection_Homo sapiens_hsa053300.75454533
45Viral carcinogenesis_Homo sapiens_hsa052030.74994794
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73539103
47B cell receptor signaling pathway_Homo sapiens_hsa046620.70041981
48HTLV-I infection_Homo sapiens_hsa051660.68637828
49Pyruvate metabolism_Homo sapiens_hsa006200.66021394
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65866608
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.65706512
52T cell receptor signaling pathway_Homo sapiens_hsa046600.64906243
53Metabolic pathways_Homo sapiens_hsa011000.64278191
54Graft-versus-host disease_Homo sapiens_hsa053320.64004323
55Propanoate metabolism_Homo sapiens_hsa006400.63760521
56Legionellosis_Homo sapiens_hsa051340.63475652
57Leishmaniasis_Homo sapiens_hsa051400.61917494
58Acute myeloid leukemia_Homo sapiens_hsa052210.61665191
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60954922
60Asthma_Homo sapiens_hsa053100.60346745
61Thyroid cancer_Homo sapiens_hsa052160.60344363
62Fatty acid elongation_Homo sapiens_hsa000620.59860054
63Folate biosynthesis_Homo sapiens_hsa007900.59503494
64Apoptosis_Homo sapiens_hsa042100.59285510
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.58244045
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56212016
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55623007
68Small cell lung cancer_Homo sapiens_hsa052220.53986447
69Type I diabetes mellitus_Homo sapiens_hsa049400.53789931
70Hepatitis B_Homo sapiens_hsa051610.53777221
71N-Glycan biosynthesis_Homo sapiens_hsa005100.53410519
72Shigellosis_Homo sapiens_hsa051310.52549398
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52283714
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50886847
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49536483
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47779086
77Viral myocarditis_Homo sapiens_hsa054160.46647277
78Regulation of autophagy_Homo sapiens_hsa041400.46406660
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46217457
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45580614
81Peroxisome_Homo sapiens_hsa041460.44715363
82Pentose phosphate pathway_Homo sapiens_hsa000300.42870673
83Sulfur metabolism_Homo sapiens_hsa009200.42101502
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40339378
85Autoimmune thyroid disease_Homo sapiens_hsa053200.39820594
86Influenza A_Homo sapiens_hsa051640.39158069
87Linoleic acid metabolism_Homo sapiens_hsa005910.36851074
88Chronic myeloid leukemia_Homo sapiens_hsa052200.36829177
89Carbon metabolism_Homo sapiens_hsa012000.35596262
90Toxoplasmosis_Homo sapiens_hsa051450.34828785
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.34753397
92Glutathione metabolism_Homo sapiens_hsa004800.34595889
93Osteoclast differentiation_Homo sapiens_hsa043800.34528188
94Alcoholism_Homo sapiens_hsa050340.34259357
95Phototransduction_Homo sapiens_hsa047440.32979661
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31686284
97Notch signaling pathway_Homo sapiens_hsa043300.31644212
98MicroRNAs in cancer_Homo sapiens_hsa052060.31340458
99Colorectal cancer_Homo sapiens_hsa052100.30765420
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30417658
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30210493
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29946359
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29698266
104Other glycan degradation_Homo sapiens_hsa005110.29424563
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28903592
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28514060
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28013554
108Collecting duct acid secretion_Homo sapiens_hsa049660.27400527
109Vitamin digestion and absorption_Homo sapiens_hsa049770.26979987
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26476998
111HIF-1 signaling pathway_Homo sapiens_hsa040660.26386482
112Malaria_Homo sapiens_hsa051440.26312794
113Cardiac muscle contraction_Homo sapiens_hsa042600.26269566
114Rheumatoid arthritis_Homo sapiens_hsa053230.26154931
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25839023
116Basal cell carcinoma_Homo sapiens_hsa052170.25633669
117Selenocompound metabolism_Homo sapiens_hsa004500.25595889
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25542430
119Pertussis_Homo sapiens_hsa051330.25439670
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25399292
121Pathways in cancer_Homo sapiens_hsa052000.24406706
122Chemical carcinogenesis_Homo sapiens_hsa052040.23963428
123Arachidonic acid metabolism_Homo sapiens_hsa005900.22397689
124Biosynthesis of amino acids_Homo sapiens_hsa012300.22267412
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22046995
126Platelet activation_Homo sapiens_hsa046110.21417759
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20266193
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.19885578
129Fat digestion and absorption_Homo sapiens_hsa049750.19286359
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19013726
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.18979693
132Tyrosine metabolism_Homo sapiens_hsa003500.17519535
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16178807
134Steroid biosynthesis_Homo sapiens_hsa001000.14885981
135Oocyte meiosis_Homo sapiens_hsa041140.14605990
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14435244
137Caffeine metabolism_Homo sapiens_hsa002320.10968005
138Nitrogen metabolism_Homo sapiens_hsa009100.09957554
139Olfactory transduction_Homo sapiens_hsa047400.09791532
140Retinol metabolism_Homo sapiens_hsa008300.09119009
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08943107
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.08538822

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