RPS13P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.54118240
2viral transcription (GO:0019083)7.08981598
3chaperone-mediated protein transport (GO:0072321)6.88834992
4ATP synthesis coupled proton transport (GO:0015986)6.85035304
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.85035304
6translational termination (GO:0006415)6.75166019
7ribosomal small subunit assembly (GO:0000028)6.63869615
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.61076026
9maturation of SSU-rRNA (GO:0030490)6.23467759
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89613726
11translational elongation (GO:0006414)5.89569104
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.78977645
13cotranslational protein targeting to membrane (GO:0006613)5.78533072
14protein targeting to ER (GO:0045047)5.74991818
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.49264537
16protein localization to endoplasmic reticulum (GO:0070972)5.43360971
17respiratory electron transport chain (GO:0022904)5.30556669
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.30235619
19electron transport chain (GO:0022900)5.20326662
20cellular protein complex disassembly (GO:0043624)5.13872290
21mitochondrial respiratory chain complex I assembly (GO:0032981)5.13538188
22NADH dehydrogenase complex assembly (GO:0010257)5.13538188
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.13538188
24viral life cycle (GO:0019058)5.00157713
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.94108777
26translational initiation (GO:0006413)4.75734901
27protein complex biogenesis (GO:0070271)4.72378889
28DNA deamination (GO:0045006)4.67997186
29rRNA modification (GO:0000154)4.51072251
30mitochondrial respiratory chain complex assembly (GO:0033108)4.50304936
31translation (GO:0006412)4.49139670
32pseudouridine synthesis (GO:0001522)4.40191261
33ribosomal large subunit biogenesis (GO:0042273)4.25517520
34protein complex disassembly (GO:0043241)4.24600730
35ATP biosynthetic process (GO:0006754)4.21862247
36negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.12786054
37respiratory chain complex IV assembly (GO:0008535)4.11923495
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.10653232
39proteasome assembly (GO:0043248)4.10243412
40ncRNA 3-end processing (GO:0043628)4.05914778
41purine nucleoside triphosphate biosynthetic process (GO:0009145)4.05625238
42macromolecular complex disassembly (GO:0032984)4.01661903
43protein neddylation (GO:0045116)3.99429155
44cellular component biogenesis (GO:0044085)3.98209384
45ribonucleoprotein complex biogenesis (GO:0022613)3.97198064
46protein targeting to mitochondrion (GO:0006626)3.96811562
47protein targeting to membrane (GO:0006612)3.89688565
48protein-cofactor linkage (GO:0018065)3.79136352
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.75797266
50GTP biosynthetic process (GO:0006183)3.75158016
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.71438853
52establishment of protein localization to mitochondrion (GO:0072655)3.68728635
53rRNA processing (GO:0006364)3.68717456
54termination of RNA polymerase III transcription (GO:0006386)3.60704270
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.60704270
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.59917767
57hydrogen ion transmembrane transport (GO:1902600)3.58579083
58peptidyl-histidine modification (GO:0018202)3.56600132
59rRNA metabolic process (GO:0016072)3.56366477
60cytochrome complex assembly (GO:0017004)3.55063480
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51476803
62mRNA catabolic process (GO:0006402)3.49645061
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47057843
64regulation of mitochondrial translation (GO:0070129)3.46436462
65intracellular protein transmembrane import (GO:0044743)3.46199349
66protein localization to mitochondrion (GO:0070585)3.43409248
67rRNA methylation (GO:0031167)3.32897275
68UTP biosynthetic process (GO:0006228)3.32860934
69negative regulation of DNA-templated transcription, elongation (GO:0032785)3.26123285
70mitochondrial transport (GO:0006839)3.26042738
71nucleoside triphosphate biosynthetic process (GO:0009142)3.24555542
72preassembly of GPI anchor in ER membrane (GO:0016254)3.23897789
73behavioral response to nicotine (GO:0035095)3.20055301
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18691260
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18691260
76pyrimidine nucleotide catabolic process (GO:0006244)3.17954561
77proton transport (GO:0015992)3.17020713
78spliceosomal snRNP assembly (GO:0000387)3.16930303
79water-soluble vitamin biosynthetic process (GO:0042364)3.13517304
80RNA catabolic process (GO:0006401)3.12503420
81DNA replication checkpoint (GO:0000076)3.12119973
82hydrogen transport (GO:0006818)3.09499691
83UTP metabolic process (GO:0046051)3.07656912
84positive regulation of prostaglandin secretion (GO:0032308)2.96175690
85guanosine-containing compound biosynthetic process (GO:1901070)2.93349008
86DNA damage response, detection of DNA damage (GO:0042769)2.89788942
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89141000
88gonadal mesoderm development (GO:0007506)2.84989360
89protein targeting (GO:0006605)2.83975533
90tRNA processing (GO:0008033)2.83437921
91ubiquinone biosynthetic process (GO:0006744)2.82095686
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.81970244
93purine nucleoside monophosphate biosynthetic process (GO:0009127)2.81970244
94protein transmembrane transport (GO:0071806)2.79714905
95pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77794458
96oxidative phosphorylation (GO:0006119)2.77053448
97ncRNA processing (GO:0034470)2.75230579
98ribosome biogenesis (GO:0042254)2.66159392
99positive regulation of fatty acid transport (GO:2000193)2.65627422
100nucleoside diphosphate phosphorylation (GO:0006165)2.63671897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32572217
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21270266
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95074126
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.68653787
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51773754
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.47005874
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34364573
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.33547496
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.33476708
10EZH2_22144423_ChIP-Seq_EOC_Human3.29949600
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77642381
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71407904
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49955048
14VDR_23849224_ChIP-Seq_CD4+_Human2.48467557
15VDR_22108803_ChIP-Seq_LS180_Human2.43959944
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27222854
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26324132
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16973234
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04353362
20FOXP3_21729870_ChIP-Seq_TREG_Human1.93504234
21XRN2_22483619_ChIP-Seq_HELA_Human1.93123109
22TTF2_22483619_ChIP-Seq_HELA_Human1.91908268
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91831601
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89836515
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.86653218
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83578933
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.80681357
28IGF1R_20145208_ChIP-Seq_DFB_Human1.80616071
29MYC_18940864_ChIP-ChIP_HL60_Human1.77483910
30ZNF274_21170338_ChIP-Seq_K562_Hela1.73107312
31DCP1A_22483619_ChIP-Seq_HELA_Human1.71990708
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.69567996
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69405689
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68488693
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65722013
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61246464
37ELK1_19687146_ChIP-ChIP_HELA_Human1.57664267
38GABP_19822575_ChIP-Seq_HepG2_Human1.57081345
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52729278
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52728721
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48561022
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.43267785
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39636071
44TP53_22573176_ChIP-Seq_HFKS_Human1.34135853
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33627324
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.33293568
47EWS_26573619_Chip-Seq_HEK293_Human1.32933321
48IRF1_19129219_ChIP-ChIP_H3396_Human1.32826133
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.32580824
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32256509
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31885946
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26846342
53FUS_26573619_Chip-Seq_HEK293_Human1.24539577
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23269438
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22877374
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19876293
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18590172
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.14257694
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13987968
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13784683
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12899389
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12196670
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11040738
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.09883098
65ERA_21632823_ChIP-Seq_H3396_Human1.08650580
66ZNF263_19887448_ChIP-Seq_K562_Human1.07985168
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04453568
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02619813
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.01139521
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00974774
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00319523
72E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99454494
73NCOR_22424771_ChIP-Seq_293T_Human0.98400640
74GATA3_21878914_ChIP-Seq_MCF-7_Human0.97613369
75CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96559752
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95605675
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95188406
78AR_20517297_ChIP-Seq_VCAP_Human0.94164970
79RNF2_27304074_Chip-Seq_NSC_Mouse0.93944682
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89635042
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89419448
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88969367
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88945248
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88753239
85P300_19829295_ChIP-Seq_ESCs_Human0.85578862
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.85430855
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84991901
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84343245
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83839303
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83525957
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83502202
92SOX2_19829295_ChIP-Seq_ESCs_Human0.83494562
93NANOG_19829295_ChIP-Seq_ESCs_Human0.83494562
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82340062
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82203801
96P53_21459846_ChIP-Seq_SAOS-2_Human0.81911478
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81471101
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81179124
99NANOG_20526341_ChIP-Seq_ESCs_Human0.81175862
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81135731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.69474035
2MP0002163_abnormal_gland_morphology4.37201875
3MP0005646_abnormal_pituitary_gland3.20869273
4MP0006292_abnormal_olfactory_placode3.14804023
5MP0006072_abnormal_retinal_apoptosis2.83981227
6MP0005379_endocrine/exocrine_gland_phen2.60378541
7MP0008875_abnormal_xenobiotic_pharmacok2.37953052
8MP0004142_abnormal_muscle_tone2.17641487
9MP0004147_increased_porphyrin_level2.15491882
10MP0001188_hyperpigmentation2.11649037
11MP0003011_delayed_dark_adaptation2.10338609
12MP0006276_abnormal_autonomic_nervous2.08310350
13MP0004885_abnormal_endolymph1.96755488
14MP0000372_irregular_coat_pigmentation1.91903681
15MP0005187_abnormal_penis_morphology1.88649224
16MP0003136_yellow_coat_color1.70830890
17MP0005253_abnormal_eye_physiology1.68922383
18MP0003693_abnormal_embryo_hatching1.64577957
19MP0002736_abnormal_nociception_after1.58689971
20MP0002277_abnormal_respiratory_mucosa1.58394242
21MP0003646_muscle_fatigue1.56860794
22MP0000049_abnormal_middle_ear1.55936128
23MP0002653_abnormal_ependyma_morphology1.55766863
24MP0004145_abnormal_muscle_electrophysio1.55706547
25MP0001986_abnormal_taste_sensitivity1.55634688
26MP0002876_abnormal_thyroid_physiology1.53044614
27MP0005551_abnormal_eye_electrophysiolog1.52242473
28MP0004215_abnormal_myocardial_fiber1.50191761
29MP0006036_abnormal_mitochondrial_physio1.48890919
30MP0002160_abnormal_reproductive_system1.48258754
31MP0003878_abnormal_ear_physiology1.39708529
32MP0005377_hearing/vestibular/ear_phenot1.39708529
33MP0005671_abnormal_response_to1.33571121
34MP0005389_reproductive_system_phenotype1.33270835
35MP0008872_abnormal_physiological_respon1.31264159
36MP0002272_abnormal_nervous_system1.28801724
37MP0001968_abnormal_touch/_nociception1.28549631
38MP0003186_abnormal_redox_activity1.28509434
39MP0002638_abnormal_pupillary_reflex1.26029949
40MP0003567_abnormal_fetal_cardiomyocyte1.25779783
41MP0003123_paternal_imprinting1.25775537
42MP0009046_muscle_twitch1.24713258
43MP0002234_abnormal_pharynx_morphology1.24088854
44MP0002837_dystrophic_cardiac_calcinosis1.23855614
45MP0001919_abnormal_reproductive_system1.23607436
46MP0003806_abnormal_nucleotide_metabolis1.21401674
47MP0005423_abnormal_somatic_nervous1.21250434
48MP0009745_abnormal_behavioral_response1.16976215
49MP0000631_abnormal_neuroendocrine_gland1.16588968
50MP0002138_abnormal_hepatobiliary_system1.15711771
51MP0003283_abnormal_digestive_organ1.15116001
52MP0001905_abnormal_dopamine_level1.12644105
53MP0001485_abnormal_pinna_reflex1.10778612
54MP0002102_abnormal_ear_morphology1.07826117
55MP0003880_abnormal_central_pattern1.03256573
56MP0002127_abnormal_cardiovascular_syste1.02065636
57MP0003786_premature_aging1.00640203
58MP0001529_abnormal_vocalization1.00255528
59MP0004742_abnormal_vestibular_system0.99306426
60MP0003195_calcinosis0.99121167
61MP0006035_abnormal_mitochondrial_morpho0.97814582
62MP0008058_abnormal_DNA_repair0.93925581
63MP0004085_abnormal_heartbeat0.90934686
64MP0008877_abnormal_DNA_methylation0.89647676
65MP0010386_abnormal_urinary_bladder0.87979478
66MP0003937_abnormal_limbs/digits/tail_de0.87755903
67MP0003137_abnormal_impulse_conducting0.86848854
68MP0000678_abnormal_parathyroid_gland0.83947816
69MP0001502_abnormal_circadian_rhythm0.83733847
70MP0002938_white_spotting0.81305381
71MP0005195_abnormal_posterior_eye0.78807129
72MP0004133_heterotaxia0.78121981
73MP0003638_abnormal_response/metabolism_0.75730184
74MP0002210_abnormal_sex_determination0.75431288
75MP0005645_abnormal_hypothalamus_physiol0.75358710
76MP0003718_maternal_effect0.75320631
77MP0001293_anophthalmia0.74944829
78MP0001501_abnormal_sleep_pattern0.74351617
79MP0005332_abnormal_amino_acid0.73599811
80MP0000230_abnormal_systemic_arterial0.73265067
81MP0001984_abnormal_olfaction0.72574467
82MP0002184_abnormal_innervation0.72511479
83MP0003315_abnormal_perineum_morphology0.72365708
84MP0005360_urolithiasis0.72119506
85MP0002095_abnormal_skin_pigmentation0.70708545
86MP0002132_abnormal_respiratory_system0.70132559
87MP0010368_abnormal_lymphatic_system0.70044948
88MP0003724_increased_susceptibility_to0.69940658
89MP0008775_abnormal_heart_ventricle0.69156776
90MP0005391_vision/eye_phenotype0.68834367
91MP0001764_abnormal_homeostasis0.68465773
92MP0002572_abnormal_emotion/affect_behav0.66959158
93MP0008789_abnormal_olfactory_epithelium0.66892432
94MP0002752_abnormal_somatic_nervous0.64740379
95MP0002064_seizures0.64686961
96MP0005410_abnormal_fertilization0.62638418
97MP0002557_abnormal_social/conspecific_i0.62622020
98MP0001440_abnormal_grooming_behavior0.62582615
99MP0000647_abnormal_sebaceous_gland0.60955067
100MP0000653_abnormal_sex_gland0.60480609

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.45419008
2Mitochondrial inheritance (HP:0001427)5.09264836
3Abnormal mitochondria in muscle tissue (HP:0008316)4.86442441
4Acute encephalopathy (HP:0006846)4.84378452
5Increased CSF lactate (HP:0002490)4.64069339
6Increased hepatocellular lipid droplets (HP:0006565)4.60756885
7Lipid accumulation in hepatocytes (HP:0006561)4.45179902
8Progressive macrocephaly (HP:0004481)4.34870213
9Hepatocellular necrosis (HP:0001404)4.11144477
10Congenital stationary night blindness (HP:0007642)4.04961973
11Hepatic necrosis (HP:0002605)3.91400911
12Abnormality of cells of the erythroid lineage (HP:0012130)3.86837848
13Renal Fanconi syndrome (HP:0001994)3.71887689
14Abnormal number of erythroid precursors (HP:0012131)3.70698599
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69978853
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69978853
17Macrocytic anemia (HP:0001972)3.65028142
18Cerebral edema (HP:0002181)3.61752800
193-Methylglutaconic aciduria (HP:0003535)3.61187861
20Increased intramyocellular lipid droplets (HP:0012240)3.58116233
21Reticulocytopenia (HP:0001896)3.27075495
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.24758101
23Increased serum lactate (HP:0002151)3.14753342
24Increased muscle lipid content (HP:0009058)3.13952728
25Lactic acidosis (HP:0003128)3.05612303
26Exertional dyspnea (HP:0002875)3.01115063
27Respiratory difficulties (HP:0002880)2.96492541
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96334662
29Concave nail (HP:0001598)2.89242604
30Respiratory failure (HP:0002878)2.79211058
31Pancreatic cysts (HP:0001737)2.72771010
32Abnormality of midbrain morphology (HP:0002418)2.70272299
33Molar tooth sign on MRI (HP:0002419)2.70272299
34Glycosuria (HP:0003076)2.60449165
35Abnormality of urine glucose concentration (HP:0011016)2.60449165
36Pallor (HP:0000980)2.58093085
37Hyperphosphaturia (HP:0003109)2.55131201
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.51877351
39Absent/shortened dynein arms (HP:0200106)2.51877351
40Type II lissencephaly (HP:0007260)2.51750717
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49634594
42Abnormality of alanine metabolism (HP:0010916)2.49634594
43Hyperalaninemia (HP:0003348)2.49634594
44Congenital, generalized hypertrichosis (HP:0004540)2.48361465
45Optic disc pallor (HP:0000543)2.44657079
46Exercise intolerance (HP:0003546)2.41425241
47Sclerocornea (HP:0000647)2.37165541
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34338062
49Abnormal rod and cone electroretinograms (HP:0008323)2.27951511
50Hyperglycinemia (HP:0002154)2.25008976
51Abnormality of renal resorption (HP:0011038)2.22931757
52Lethargy (HP:0001254)2.20574047
53Testicular atrophy (HP:0000029)2.17324216
54Leukodystrophy (HP:0002415)2.16182674
55Absent thumb (HP:0009777)2.13479958
56Aplasia/hypoplasia of the uterus (HP:0008684)2.13255253
57Hypoplasia of the uterus (HP:0000013)2.11608401
58Progressive microcephaly (HP:0000253)2.11301765
59IgG deficiency (HP:0004315)2.10734667
60Methylmalonic acidemia (HP:0002912)2.07872113
61True hermaphroditism (HP:0010459)2.05736127
62CNS demyelination (HP:0007305)2.04094667
63Abdominal situs inversus (HP:0003363)2.02258941
64Abnormality of abdominal situs (HP:0011620)2.02258941
65Methylmalonic aciduria (HP:0012120)2.02011895
66Microretrognathia (HP:0000308)2.01424520
67Type 2 muscle fiber atrophy (HP:0003554)1.99828967
68Increased serum pyruvate (HP:0003542)1.98083100
69Pancreatic fibrosis (HP:0100732)1.97775694
70Hypoplasia of the radius (HP:0002984)1.97152754
71Occipital encephalocele (HP:0002085)1.96949296
72Cleft eyelid (HP:0000625)1.94295429
73Triphalangeal thumb (HP:0001199)1.93356714
74Symphalangism affecting the phalanges of the hand (HP:0009773)1.90905153
75Abnormality of the middle phalanges of the toes (HP:0010183)1.90394532
76Nephronophthisis (HP:0000090)1.88605843
77Colon cancer (HP:0003003)1.88025233
78Generalized aminoaciduria (HP:0002909)1.87415177
79Hyperglycinuria (HP:0003108)1.87403051
80Abnormal urine phosphate concentration (HP:0012599)1.86880185
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86260081
82Aplastic anemia (HP:0001915)1.81224954
83Abnormality of the phalanges of the 5th finger (HP:0004213)1.78337748
84Muscle fiber atrophy (HP:0100295)1.77244924
85Conical tooth (HP:0000698)1.76055488
86Pendular nystagmus (HP:0012043)1.75576080
87Abnormal hemoglobin (HP:0011902)1.74306815
88Delayed CNS myelination (HP:0002188)1.70085535
89Forearm undergrowth (HP:0009821)1.68435874
90Abnormal number of incisors (HP:0011064)1.65824732
91Absent phalangeal crease (HP:0006109)1.65816550
92Anencephaly (HP:0002323)1.65744905
93Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64423878
94Renal cortical cysts (HP:0000803)1.64002849
95Preaxial hand polydactyly (HP:0001177)1.62947454
96X-linked dominant inheritance (HP:0001423)1.62645890
97Medial flaring of the eyebrow (HP:0010747)1.62273431
98Pancytopenia (HP:0001876)1.61370883
99Abnormality of the renal cortex (HP:0011035)1.60929294
100Abnormality of glycine metabolism (HP:0010895)1.60059699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.12920400
2TLK14.08262225
3ZAK3.31305093
4NME23.27682538
5PDK23.23957219
6BCKDK2.73326891
7TAOK32.68669432
8VRK22.39117168
9ADRBK22.23741794
10BUB12.17456520
11PINK12.08299251
12PLK41.91414344
13BLK1.89764482
14NME11.69451680
15NUAK11.66305696
16DYRK21.63338851
17NEK11.59172637
18MAP4K21.57861095
19TXK1.49644881
20WNK41.47761393
21BMPR1B1.46460099
22MAP3K41.38509941
23VRK11.37593970
24IKBKB1.35630307
25TIE11.33544031
26PHKG21.21341317
27PHKG11.21341317
28OBSCN1.19030058
29PASK1.14603836
30MAP2K71.07947002
31GRK61.07194773
32AURKA1.05470461
33STK161.04631553
34SRPK11.02404487
35MAP2K21.01239699
36PRKCG0.98164278
37LRRK20.97249262
38CDC70.95246870
39MUSK0.92184807
40KDR0.89500963
41RPS6KA50.87057388
42MAPK130.85394603
43STK390.83936983
44TGFBR10.78420062
45TNIK0.75780888
46INSRR0.75402295
47STK40.74538499
48CSNK2A20.72604364
49MKNK20.71822649
50AURKB0.70503036
51ABL20.69817551
52TEC0.69192242
53MAP3K90.68080556
54PRKACA0.67140778
55DAPK10.66769257
56CHEK20.66096455
57NTRK20.65972365
58PIM10.64190991
59FRK0.63484077
60DYRK30.61744779
61TRIM280.61561191
62DAPK20.61074781
63PIK3CA0.60797309
64CAMK2A0.60662267
65IKBKE0.60279757
66CSNK2A10.60253199
67MYLK0.57591180
68PAK30.57562464
69PIM20.57500503
70ILK0.56938574
71PLK10.56926296
72CSNK1G10.56620625
73CSNK1G20.56598197
74RPS6KA40.56394722
75CSNK1G30.55678205
76EIF2AK20.55152316
77CDK190.55047765
78LIMK10.54803290
79RPS6KA60.54217555
80ADRBK10.54111151
81PRKCI0.53903572
82GRK70.53241525
83TSSK60.52324320
84CAMK10.51190581
85CAMKK20.51178706
86PRKCQ0.50837071
87ARAF0.50705353
88MAPKAPK30.50637182
89WNK30.50074940
90MAP3K120.49717372
91CDK80.49178600
92CSNK1A10.48836482
93MKNK10.48328739
94BRAF0.47541107
95SYK0.46719743
96MST40.45395091
97ITK0.45349268
98PRKCE0.45245387
99PLK30.44389430
100PRKACG0.41695900

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.16654866
2Oxidative phosphorylation_Homo sapiens_hsa001904.89723769
3Parkinsons disease_Homo sapiens_hsa050124.17969858
4Huntingtons disease_Homo sapiens_hsa050162.90198667
5Alzheimers disease_Homo sapiens_hsa050102.87793886
6RNA polymerase_Homo sapiens_hsa030202.84190905
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.67378478
8Proteasome_Homo sapiens_hsa030502.61981356
9Cardiac muscle contraction_Homo sapiens_hsa042602.33877343
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17484494
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12268231
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05146424
13Sulfur relay system_Homo sapiens_hsa041221.99518931
14Protein export_Homo sapiens_hsa030601.96366155
15Homologous recombination_Homo sapiens_hsa034401.89511932
16One carbon pool by folate_Homo sapiens_hsa006701.83844871
17Pyrimidine metabolism_Homo sapiens_hsa002401.61928586
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51594328
19Spliceosome_Homo sapiens_hsa030401.45920234
20RNA degradation_Homo sapiens_hsa030181.42442272
21Linoleic acid metabolism_Homo sapiens_hsa005911.40525310
22DNA replication_Homo sapiens_hsa030301.39877151
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24948995
24Basal transcription factors_Homo sapiens_hsa030221.23779294
25Caffeine metabolism_Homo sapiens_hsa002321.20840007
26Primary immunodeficiency_Homo sapiens_hsa053401.18233498
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17875680
28Sulfur metabolism_Homo sapiens_hsa009201.17073109
29Phototransduction_Homo sapiens_hsa047441.15993592
30Base excision repair_Homo sapiens_hsa034101.13727286
31Purine metabolism_Homo sapiens_hsa002301.11966759
32Fanconi anemia pathway_Homo sapiens_hsa034601.09265088
33Mismatch repair_Homo sapiens_hsa034301.08667721
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03589080
35Asthma_Homo sapiens_hsa053101.02535586
36RNA transport_Homo sapiens_hsa030131.02152689
37Propanoate metabolism_Homo sapiens_hsa006401.02108768
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.00670171
39Nucleotide excision repair_Homo sapiens_hsa034201.00265715
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95748202
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90361665
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.90027898
43Metabolic pathways_Homo sapiens_hsa011000.85270623
44Butanoate metabolism_Homo sapiens_hsa006500.83731426
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82223141
46Selenocompound metabolism_Homo sapiens_hsa004500.79960806
47Arachidonic acid metabolism_Homo sapiens_hsa005900.76246728
48Peroxisome_Homo sapiens_hsa041460.74506160
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73904204
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73233675
51Chemical carcinogenesis_Homo sapiens_hsa052040.70305177
52Folate biosynthesis_Homo sapiens_hsa007900.70193218
53Nitrogen metabolism_Homo sapiens_hsa009100.69676111
54Nicotine addiction_Homo sapiens_hsa050330.69534845
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69048414
56Tryptophan metabolism_Homo sapiens_hsa003800.68922802
57Vitamin B6 metabolism_Homo sapiens_hsa007500.64788320
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62537374
59Collecting duct acid secretion_Homo sapiens_hsa049660.60855750
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60276836
61Retinol metabolism_Homo sapiens_hsa008300.59832140
62Pyruvate metabolism_Homo sapiens_hsa006200.56835197
63Ether lipid metabolism_Homo sapiens_hsa005650.56817862
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.56336140
65Allograft rejection_Homo sapiens_hsa053300.56263574
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55507061
67Fat digestion and absorption_Homo sapiens_hsa049750.55156468
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55155893
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54792194
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51889893
71beta-Alanine metabolism_Homo sapiens_hsa004100.51624049
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51520664
73Autoimmune thyroid disease_Homo sapiens_hsa053200.51496422
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.51232119
75Systemic lupus erythematosus_Homo sapiens_hsa053220.49358297
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.44384099
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44086209
78Olfactory transduction_Homo sapiens_hsa047400.42345771
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41458284
80Fatty acid degradation_Homo sapiens_hsa000710.39999936
81Glutathione metabolism_Homo sapiens_hsa004800.37821726
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37169675
83Taste transduction_Homo sapiens_hsa047420.36500256
84Morphine addiction_Homo sapiens_hsa050320.36416838
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.35554322
86Tyrosine metabolism_Homo sapiens_hsa003500.32697865
87Fatty acid elongation_Homo sapiens_hsa000620.30056710
88Vitamin digestion and absorption_Homo sapiens_hsa049770.29453365
89Phenylalanine metabolism_Homo sapiens_hsa003600.28630723
90Graft-versus-host disease_Homo sapiens_hsa053320.28143900
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27362746
92Type I diabetes mellitus_Homo sapiens_hsa049400.24669356
93Steroid biosynthesis_Homo sapiens_hsa001000.23405593
94Arginine and proline metabolism_Homo sapiens_hsa003300.20566712
95Fatty acid metabolism_Homo sapiens_hsa012120.18466024
96Serotonergic synapse_Homo sapiens_hsa047260.16450132
97Regulation of autophagy_Homo sapiens_hsa041400.15621602
98Rheumatoid arthritis_Homo sapiens_hsa053230.15372115
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14238095
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13647826

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