RPS14P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)5.54666237
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.52184793
3negative regulation of cell killing (GO:0031342)5.52184793
4regulation of memory T cell differentiation (GO:0043380)5.27916167
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.97295156
6DNA deamination (GO:0045006)4.83220055
7sleep (GO:0030431)4.67906948
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.65367535
9regulation of T cell mediated cytotoxicity (GO:0001914)4.47698914
10positive regulation of T cell mediated cytotoxicity (GO:0001916)4.45819972
11positive regulation of defense response to virus by host (GO:0002230)4.30254257
12negative regulation of DNA-templated transcription, elongation (GO:0032785)4.20655391
13response to interleukin-15 (GO:0070672)4.18277682
14mast cell activation (GO:0045576)4.11113086
15positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.09570154
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04264899
17negative T cell selection (GO:0043383)3.90204618
18regulation of germinal center formation (GO:0002634)3.89590062
19regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.81702760
20positive regulation of T-helper 1 type immune response (GO:0002827)3.80090167
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78946209
22tolerance induction (GO:0002507)3.78548866
23regulation of regulatory T cell differentiation (GO:0045589)3.77942324
24regulation of leukocyte mediated cytotoxicity (GO:0001910)3.72273274
25negative thymic T cell selection (GO:0045060)3.68052411
26positive regulation of prostaglandin secretion (GO:0032308)3.67322304
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64352417
28regulation of mitotic spindle checkpoint (GO:1903504)3.64352417
29regulation of activation of Janus kinase activity (GO:0010533)3.60655281
30positive regulation of T cell differentiation in thymus (GO:0033089)3.57630455
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.57607568
32positive regulation of T cell cytokine production (GO:0002726)3.56881943
33positive regulation of T cell mediated immunity (GO:0002711)3.55459927
34regulation of B cell receptor signaling pathway (GO:0050855)3.52964651
35preassembly of GPI anchor in ER membrane (GO:0016254)3.51261911
36regulation of immunoglobulin secretion (GO:0051023)3.46858332
37mast cell degranulation (GO:0043303)3.45646091
38mast cell activation involved in immune response (GO:0002279)3.45646091
39positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.43715238
40regulation of cell killing (GO:0031341)3.38654381
41response to gravity (GO:0009629)3.35294501
42regulation of T-helper 1 type immune response (GO:0002825)3.33762044
43regulation of T cell receptor signaling pathway (GO:0050856)3.33359884
44cytidine metabolic process (GO:0046087)3.32426974
45cytidine catabolic process (GO:0006216)3.32426974
46cytidine deamination (GO:0009972)3.32426974
47positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.22774273
48positive regulation of osteoclast differentiation (GO:0045672)3.20776440
49dendritic cell chemotaxis (GO:0002407)3.20420607
50interferon-gamma production (GO:0032609)3.19501173
51positive regulation of cell killing (GO:0031343)3.19081417
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18290626
53regulation of defense response to virus by host (GO:0050691)3.18005347
54negative regulation of mast cell activation (GO:0033004)3.16604607
55regulation of T cell mediated immunity (GO:0002709)3.13551620
56regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.12582498
57rRNA catabolic process (GO:0016075)3.10991971
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10982548
59endoderm formation (GO:0001706)3.08119935
60positive regulation of interleukin-17 production (GO:0032740)3.07080185
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06283846
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06283846
63regulation of hypersensitivity (GO:0002883)3.05723154
64regulation of prostaglandin secretion (GO:0032306)3.02870526
65regulation of gamma-delta T cell differentiation (GO:0045586)3.02837712
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97178369
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97178369
68isotype switching (GO:0045190)2.97178369
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95621724
70pyrimidine ribonucleoside catabolic process (GO:0046133)2.93881999
71cellular defense response (GO:0006968)2.93500847
72mitotic cell cycle arrest (GO:0071850)2.92250653
73regulation of isotype switching to IgG isotypes (GO:0048302)2.88979654
74negative regulation of meiotic cell cycle (GO:0051447)2.87252647
75positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.86337166
76GPI anchor metabolic process (GO:0006505)2.85635607
77behavioral response to nicotine (GO:0035095)2.83988542
78GPI anchor biosynthetic process (GO:0006506)2.81073915
79protein-cofactor linkage (GO:0018065)2.80415774
80positive regulation of fatty acid transport (GO:2000193)2.80376934
81platelet dense granule organization (GO:0060155)2.79787636
82ATP synthesis coupled proton transport (GO:0015986)2.78901247
83energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78901247
84positive regulation of cell fate commitment (GO:0010455)2.78810281
85positive regulation of lymphocyte mediated immunity (GO:0002708)2.75000583
86protein polyglutamylation (GO:0018095)2.72955938
87T-helper cell differentiation (GO:0042093)2.72523495
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72523495
89regulation of alpha-beta T cell proliferation (GO:0046640)2.71767655
90positive regulation of adaptive immune response (GO:0002821)2.71354883
91positive regulation of activated T cell proliferation (GO:0042104)2.67654348
92alpha-beta T cell differentiation (GO:0046632)2.66348043
93regulation of chronic inflammatory response (GO:0002676)2.65815344
94positive regulation of icosanoid secretion (GO:0032305)2.65522701
95mannosylation (GO:0097502)2.65195108
96antigen processing and presentation via MHC class Ib (GO:0002475)2.64596348
97dendritic cell migration (GO:0036336)2.64545324
98negative regulation of interleukin-1 beta production (GO:0032691)2.64054656
99regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.59192427
100peptidyl-threonine dephosphorylation (GO:0035970)2.58309997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.29277285
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11297100
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02793935
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.95294520
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.90240359
6RUNX_20019798_ChIP-Seq_JUKART_Human2.77245622
7ZNF274_21170338_ChIP-Seq_K562_Hela2.76932749
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64790905
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.60239818
10GATA3_26560356_Chip-Seq_TH2_Human2.41503892
11VDR_22108803_ChIP-Seq_LS180_Human2.40501647
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40107493
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39061923
14VDR_23849224_ChIP-Seq_CD4+_Human2.34498385
15MYB_26560356_Chip-Seq_TH2_Human2.30559068
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28072689
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24387857
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13095332
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08342446
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.06374789
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06114192
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.05015405
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01144178
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93255993
25GATA3_27048872_Chip-Seq_THYMUS_Human1.84743556
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.83086326
27IRF1_19129219_ChIP-ChIP_H3396_Human1.82666075
28MYC_18940864_ChIP-ChIP_HL60_Human1.76999934
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74012808
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69606747
31FOXP3_21729870_ChIP-Seq_TREG_Human1.69385435
32IGF1R_20145208_ChIP-Seq_DFB_Human1.63892438
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58223771
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57522022
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56518000
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53327833
37TP53_22573176_ChIP-Seq_HFKS_Human1.52138898
38AR_20517297_ChIP-Seq_VCAP_Human1.51457398
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50085995
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.47208655
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46960652
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45918938
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.44649765
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42481838
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.42481838
46ELK1_19687146_ChIP-ChIP_HELA_Human1.39533635
47TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36435454
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34783484
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32809409
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31613483
51MYB_26560356_Chip-Seq_TH1_Human1.31376347
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29696020
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25563629
54TAF15_26573619_Chip-Seq_HEK293_Human1.24795827
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24475837
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24392511
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21894900
58RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21640168
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21592238
60HOXB7_26014856_ChIP-Seq_BT474_Human1.20977780
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19521290
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14647682
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.14489482
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.14225524
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12424184
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11356472
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.10814852
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10045505
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09837918
70CBP_20019798_ChIP-Seq_JUKART_Human1.09748013
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09748013
72ER_23166858_ChIP-Seq_MCF-7_Human1.09498693
73BCL6_27268052_Chip-Seq_Bcells_Human1.09496438
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09050388
75NANOG_20526341_ChIP-Seq_ESCs_Human1.08398822
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08382433
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08103442
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06905258
79SPI1_23547873_ChIP-Seq_NB4_Human1.06638008
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06267299
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06139583
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05678314
83ERA_21632823_ChIP-Seq_H3396_Human1.05139838
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04601966
85NCOR_22424771_ChIP-Seq_293T_Human1.01930172
86GATA3_26560356_Chip-Seq_TH1_Human1.01292817
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00705804
88MYC_19829295_ChIP-Seq_ESCs_Human0.99873274
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99695018
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99225227
91NANOG_19829295_ChIP-Seq_ESCs_Human0.98942519
92SOX2_19829295_ChIP-Seq_ESCs_Human0.98942519
93TAF2_19829295_ChIP-Seq_ESCs_Human0.98490290
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.98009306
95STAT1_20625510_ChIP-Seq_HELA_Human0.96924103
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96893786
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96730163
98P300_27268052_Chip-Seq_Bcells_Human0.95494107
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93465936
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93182678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.22878029
2MP0003724_increased_susceptibility_to3.84962144
3MP0001835_abnormal_antigen_presentation3.43213475
4MP0005000_abnormal_immune_tolerance2.91868478
5MP0003436_decreased_susceptibility_to2.89760906
6MP0000685_abnormal_immune_system2.79678970
7MP0003763_abnormal_thymus_physiology2.76651280
8MP0004147_increased_porphyrin_level2.57955365
9MP0001800_abnormal_humoral_immune2.50515768
10MP0006072_abnormal_retinal_apoptosis2.43602418
11MP0005075_abnormal_melanosome_morpholog2.41193751
12MP0003195_calcinosis2.41168812
13MP0009785_altered_susceptibility_to2.38853880
14MP0002148_abnormal_hypersensitivity_rea2.33485662
15MP0002723_abnormal_immune_serum2.29275141
16MP0002876_abnormal_thyroid_physiology2.13014614
17MP0001819_abnormal_immune_cell2.03618984
18MP0002452_abnormal_antigen_presenting2.02440294
19MP0000465_gastrointestinal_hemorrhage2.01088682
20MP0002420_abnormal_adaptive_immunity1.99361597
21MP0004885_abnormal_endolymph1.97120326
22MP0003866_abnormal_defecation1.91913922
23MP0001533_abnormal_skeleton_physiology1.79987953
24MP0002166_altered_tumor_susceptibility1.78138874
25MP0005025_abnormal_response_to1.75261949
26MP0001986_abnormal_taste_sensitivity1.75168223
27MP0001501_abnormal_sleep_pattern1.63855234
28MP0002419_abnormal_innate_immunity1.63376742
29MP0002009_preneoplasia1.62462143
30MP0008877_abnormal_DNA_methylation1.56823889
31MP0001790_abnormal_immune_system1.56020437
32MP0005387_immune_system_phenotype1.56020437
33MP0002405_respiratory_system_inflammati1.55502407
34MP0009764_decreased_sensitivity_to1.55200499
35MP0008872_abnormal_physiological_respon1.53670618
36MP0002138_abnormal_hepatobiliary_system1.52612472
37MP0002933_joint_inflammation1.52496890
38MP0004947_skin_inflammation1.51487122
39MP0009333_abnormal_splenocyte_physiolog1.50814978
40MP0008875_abnormal_xenobiotic_pharmacok1.48747561
41MP0002398_abnormal_bone_marrow1.45349426
42MP0001845_abnormal_inflammatory_respons1.45012956
43MP0003252_abnormal_bile_duct1.43662180
44MP0000716_abnormal_immune_system1.43337270
45MP0010155_abnormal_intestine_physiology1.42682935
46MP0002102_abnormal_ear_morphology1.41847061
47MP0002006_tumorigenesis1.41682814
48MP0005377_hearing/vestibular/ear_phenot1.41585035
49MP0003878_abnormal_ear_physiology1.41585035
50MP0000689_abnormal_spleen_morphology1.37174735
51MP0003011_delayed_dark_adaptation1.34344415
52MP0005253_abnormal_eye_physiology1.33595619
53MP0005551_abnormal_eye_electrophysiolog1.28257102
54MP0001919_abnormal_reproductive_system1.25328419
55MP0002722_abnormal_immune_system1.24107596
56MP0000703_abnormal_thymus_morphology1.24062416
57MP0002163_abnormal_gland_morphology1.18960235
58MP0003638_abnormal_response/metabolism_1.14602143
59MP0002736_abnormal_nociception_after1.11399161
60MP0003646_muscle_fatigue1.09430473
61MP0001765_abnormal_ion_homeostasis1.08764545
62MP0001968_abnormal_touch/_nociception1.08411051
63MP0002429_abnormal_blood_cell1.08159119
64MP0000372_irregular_coat_pigmentation1.07105646
65MP0005167_abnormal_blood-brain_barrier1.06502269
66MP0003786_premature_aging1.05790480
67MP0001853_heart_inflammation1.01693670
68MP0005084_abnormal_gallbladder_morpholo1.01524214
69MP0005174_abnormal_tail_pigmentation1.01361448
70MP0006082_CNS_inflammation1.00921533
71MP0005360_urolithiasis0.99986605
72MP0005645_abnormal_hypothalamus_physiol0.98577895
73MP0008469_abnormal_protein_level0.97061659
74MP0004381_abnormal_hair_follicle0.93999235
75MP0002837_dystrophic_cardiac_calcinosis0.87100093
76MP0001873_stomach_inflammation0.87038272
77MP0005379_endocrine/exocrine_gland_phen0.85366009
78MP0005365_abnormal_bile_salt0.83849398
79MP0005310_abnormal_salivary_gland0.83602207
80MP0005085_abnormal_gallbladder_physiolo0.81950860
81MP0005389_reproductive_system_phenotype0.81171285
82MP0005332_abnormal_amino_acid0.80578800
83MP0002095_abnormal_skin_pigmentation0.80204891
84MP0008995_early_reproductive_senescence0.79987270
85MP0005646_abnormal_pituitary_gland0.78458089
86MP0005390_skeleton_phenotype0.77774170
87MP0010329_abnormal_lipoprotein_level0.73610297
88MP0001984_abnormal_olfaction0.71594709
89MP0008775_abnormal_heart_ventricle0.70263719
90MP0004145_abnormal_muscle_electrophysio0.70151867
91MP0004043_abnormal_pH_regulation0.68903556
92MP0002254_reproductive_system_inflammat0.67844155
93MP0009763_increased_sensitivity_to0.67441964
94MP0005636_abnormal_mineral_homeostasis0.66200957
95MP0002234_abnormal_pharynx_morphology0.64834454
96MP0003806_abnormal_nucleotide_metabolis0.61549255
97MP0004142_abnormal_muscle_tone0.61267005
98MP0001119_abnormal_female_reproductive0.60111036
99MP0000427_abnormal_hair_cycle0.57925092
100MP0001905_abnormal_dopamine_level0.57042992

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)6.11721746
2Severe combined immunodeficiency (HP:0004430)4.62748288
3Abnormality of eosinophils (HP:0001879)3.89845480
4Stomach cancer (HP:0012126)3.82147586
5Abnormality of T cell number (HP:0011839)3.77414942
6T lymphocytopenia (HP:0005403)3.67403758
7Retrobulbar optic neuritis (HP:0100654)3.66076804
8Optic neuritis (HP:0100653)3.66076804
9Elevated erythrocyte sedimentation rate (HP:0003565)3.62770121
10Myositis (HP:0100614)3.58557690
11Combined immunodeficiency (HP:0005387)3.57245126
12Renal cortical cysts (HP:0000803)3.33855794
13Thyroiditis (HP:0100646)3.32081293
143-Methylglutaconic aciduria (HP:0003535)3.30961903
15Abnormality of T cells (HP:0002843)3.30408898
16Prostate neoplasm (HP:0100787)3.26183247
17Stomatitis (HP:0010280)3.05683956
18Orchitis (HP:0100796)2.99653184
19Abnormality of B cell number (HP:0010975)2.99149244
20Abnormality of T cell physiology (HP:0011840)2.98275136
21Abnormality of the renal cortex (HP:0011035)2.92113377
22Congenital stationary night blindness (HP:0007642)2.80461684
23Conical tooth (HP:0000698)2.79044292
24Abnormality of the prostate (HP:0008775)2.74302919
25Congenital, generalized hypertrichosis (HP:0004540)2.74155648
26Pancreatic cysts (HP:0001737)2.70823934
27Eosinophilia (HP:0001880)2.70655734
28Pulmonary infiltrates (HP:0002113)2.68947134
29Hepatocellular necrosis (HP:0001404)2.58745756
30Keratoconjunctivitis (HP:0001096)2.56084933
31Abolished electroretinogram (ERG) (HP:0000550)2.51098845
32Mitochondrial inheritance (HP:0001427)2.50214901
33B lymphocytopenia (HP:0010976)2.43237564
34Pustule (HP:0200039)2.41984820
35Increased CSF lactate (HP:0002490)2.38749431
36Leukocytosis (HP:0001974)2.36844953
37Increased IgM level (HP:0003496)2.36676394
38Short tibia (HP:0005736)2.35713314
39Hypoproteinemia (HP:0003075)2.33957356
40Type II lissencephaly (HP:0007260)2.29648125
41Keratoconjunctivitis sicca (HP:0001097)2.26910779
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.25951102
43Hepatic necrosis (HP:0002605)2.25632196
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25524584
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25524584
46Pulmonary fibrosis (HP:0002206)2.23323955
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.18626917
48Nephronophthisis (HP:0000090)2.18483146
49Lipid accumulation in hepatocytes (HP:0006561)2.16564853
50Increased serum lactate (HP:0002151)2.15357381
51Molar tooth sign on MRI (HP:0002419)2.14203704
52Abnormality of midbrain morphology (HP:0002418)2.14203704
53Methylmalonic acidemia (HP:0002912)2.10651455
54Granulocytopenia (HP:0001913)2.10378105
55Panhypogammaglobulinemia (HP:0003139)2.07849286
56Aplasia/hypoplasia of the uterus (HP:0008684)2.07367971
57Brittle hair (HP:0002299)2.03178019
58Acute necrotizing encephalopathy (HP:0006965)2.02998913
59Attenuation of retinal blood vessels (HP:0007843)2.01677470
60Recurrent bronchitis (HP:0002837)1.99438691
61Vasculitis (HP:0002633)1.98873237
62Pancreatic fibrosis (HP:0100732)1.98536688
63Progressive microcephaly (HP:0000253)1.97755934
64Encephalitis (HP:0002383)1.97624340
65Neutropenia (HP:0001875)1.95937328
66Chronic diarrhea (HP:0002028)1.95393413
67Pancreatitis (HP:0001733)1.94982141
68IgM deficiency (HP:0002850)1.93850074
69Increased intramyocellular lipid droplets (HP:0012240)1.91478332
70Abnormal mitochondria in muscle tissue (HP:0008316)1.90842963
71Abnormality of the renal collecting system (HP:0004742)1.90248331
72Gangrene (HP:0100758)1.89925346
73Duplicated collecting system (HP:0000081)1.89140402
74Abnormality of the renal medulla (HP:0100957)1.88909510
75Absent thumb (HP:0009777)1.88391369
76True hermaphroditism (HP:0010459)1.87239377
77Joint swelling (HP:0001386)1.87033060
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86944192
79Increased hepatocellular lipid droplets (HP:0006565)1.86812433
80Anorexia (HP:0002039)1.83900309
81Lactic acidosis (HP:0003128)1.83807139
82Increased muscle lipid content (HP:0009058)1.83625640
83Hypokalemic alkalosis (HP:0001949)1.83069248
84Recurrent fungal infections (HP:0002841)1.82965681
85Pancytopenia (HP:0001876)1.82130361
86Hypoplasia of the uterus (HP:0000013)1.81894932
87Abnormal number of erythroid precursors (HP:0012131)1.81804868
88Methylmalonic aciduria (HP:0012120)1.80762897
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79638083
90Type I transferrin isoform profile (HP:0003642)1.78390001
91Hemoptysis (HP:0002105)1.77274337
92Abnormality of the pons (HP:0007361)1.76828471
93Abnormality of alanine metabolism (HP:0010916)1.76464482
94Hyperalaninemia (HP:0003348)1.76464482
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76464482
96Anhidrosis (HP:0000970)1.76441698
97Type 2 muscle fiber atrophy (HP:0003554)1.76389089
98Keratitis (HP:0000491)1.74628137
99Autoimmune thrombocytopenia (HP:0001973)1.72868410
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72124828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.93550548
2TAOK34.73371766
3GRK63.70980749
4TLK13.52352722
5MAP4K23.47072686
6MAP2K23.04699980
7ZAK2.91654431
8MAP3K142.77201055
9TESK22.34016077
10IKBKB2.08058051
11BCKDK2.03107494
12ADRBK21.93880086
13KDR1.86590940
14MAP4K11.83941965
15GRK11.82465166
16BMPR21.77579845
17EPHA31.68547392
18FES1.66860401
19TBK11.58457464
20NUAK11.55693639
21IKBKE1.49588891
22JAK11.46823638
23KIT1.44912552
24TIE11.34522430
25WNK41.22731600
26ITK1.17563729
27MATK1.16556355
28PINK11.13640981
29MUSK1.12500531
30EIF2AK21.11980134
31SYK1.11770754
32GRK51.05897233
33GRK71.03371492
34TEC0.98388043
35LYN0.92639518
36LCK0.91804041
37FRK0.88812692
38PIM10.88734966
39ZAP700.87806844
40OXSR10.87725360
41VRK20.86450768
42MAP3K120.86375971
43MST40.84114805
44CAMKK20.82314958
45MAPKAPK30.77287253
46LIMK10.75992908
47JAK30.74974843
48TRIM280.74364255
49BTK0.73279279
50PHKG10.72105130
51PHKG20.72105130
52CSF1R0.72057115
53IGF1R0.70814739
54CHUK0.69693746
55ERBB30.68837150
56MAPK70.67870978
57PRKCQ0.67553138
58MYLK0.65722207
59STK390.65285030
60DAPK10.62376247
61SCYL20.61028619
62IRAK40.60016907
63INSRR0.59219242
64CDK190.58704389
65HCK0.58331497
66MAP3K40.55321685
67ACVR1B0.54390392
68WNK30.51439182
69NME10.51146467
70VRK10.50035306
71MAP3K130.48144590
72CDK80.47978103
73ADRBK10.46960108
74RPS6KA50.46676047
75IRAK10.46090463
76BMPR1B0.46085203
77SRPK10.45763666
78TRPM70.43472505
79CAMKK10.43215645
80MAP2K10.40460812
81SIK20.37933117
82ABL10.37333905
83OBSCN0.36318620
84TNK20.33235355
85RIPK40.32969907
86PASK0.31367703
87NLK0.31039212
88MAP2K60.31032479
89CDK40.30927485
90MARK30.30656389
91MAPK130.28993654
92EGFR0.27627957
93MAPKAPK20.27560059
94CSK0.26841143
95PIK3CG0.26512691
96STK160.25557971
97MAPK110.25477065
98PRKCD0.25431169
99STK100.25254776
100CSNK1G30.23560425

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.33845702
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.18936591
3Graft-versus-host disease_Homo sapiens_hsa053323.11862662
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02934321
5Asthma_Homo sapiens_hsa053102.88382442
6Allograft rejection_Homo sapiens_hsa053302.67389696
7Autoimmune thyroid disease_Homo sapiens_hsa053202.57303882
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54276092
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39279763
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19418144
11Oxidative phosphorylation_Homo sapiens_hsa001902.10834741
12Type I diabetes mellitus_Homo sapiens_hsa049402.01828871
13Antigen processing and presentation_Homo sapiens_hsa046121.95933476
14Proteasome_Homo sapiens_hsa030501.84282023
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83846353
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.83767233
17RNA polymerase_Homo sapiens_hsa030201.82972038
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63102104
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59994905
20Linoleic acid metabolism_Homo sapiens_hsa005911.58053127
21Ribosome_Homo sapiens_hsa030101.57980587
22Phototransduction_Homo sapiens_hsa047441.54849217
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54082777
24Parkinsons disease_Homo sapiens_hsa050121.52627667
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44413920
26Protein export_Homo sapiens_hsa030601.43677688
27Nitrogen metabolism_Homo sapiens_hsa009101.42411681
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40607446
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38683023
30Rheumatoid arthritis_Homo sapiens_hsa053231.35898736
31Caffeine metabolism_Homo sapiens_hsa002321.35162066
32Hematopoietic cell lineage_Homo sapiens_hsa046401.28603387
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27926859
34T cell receptor signaling pathway_Homo sapiens_hsa046601.25336589
35Homologous recombination_Homo sapiens_hsa034401.22127879
36Tryptophan metabolism_Homo sapiens_hsa003801.20924046
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18274461
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15816017
39Fanconi anemia pathway_Homo sapiens_hsa034601.13720732
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12911695
41RNA degradation_Homo sapiens_hsa030181.09749634
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00449558
43Alzheimers disease_Homo sapiens_hsa050101.00076018
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98427450
45Arachidonic acid metabolism_Homo sapiens_hsa005900.98104706
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.98084366
47Chemical carcinogenesis_Homo sapiens_hsa052040.94376067
48Leishmaniasis_Homo sapiens_hsa051400.89469607
49Peroxisome_Homo sapiens_hsa041460.84090584
50Herpes simplex infection_Homo sapiens_hsa051680.84020953
51Pyrimidine metabolism_Homo sapiens_hsa002400.82226950
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81177165
53Sulfur metabolism_Homo sapiens_hsa009200.80600219
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.79418167
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79187173
56Viral myocarditis_Homo sapiens_hsa054160.79021188
57Regulation of autophagy_Homo sapiens_hsa041400.78940887
58Huntingtons disease_Homo sapiens_hsa050160.78635711
59Purine metabolism_Homo sapiens_hsa002300.78610209
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76370960
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73329692
62Retinol metabolism_Homo sapiens_hsa008300.72886659
63One carbon pool by folate_Homo sapiens_hsa006700.70955498
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69279542
65Measles_Homo sapiens_hsa051620.68814511
66Cardiac muscle contraction_Homo sapiens_hsa042600.67525996
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.66385793
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66204786
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.62436336
70TNF signaling pathway_Homo sapiens_hsa046680.60568332
71Basal transcription factors_Homo sapiens_hsa030220.60213633
72Propanoate metabolism_Homo sapiens_hsa006400.58973600
73Nicotine addiction_Homo sapiens_hsa050330.57682855
74Olfactory transduction_Homo sapiens_hsa047400.56863964
75Morphine addiction_Homo sapiens_hsa050320.56332918
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52391307
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49918736
78Taste transduction_Homo sapiens_hsa047420.49353037
79Ether lipid metabolism_Homo sapiens_hsa005650.48556966
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.48339160
81Legionellosis_Homo sapiens_hsa051340.48199100
82Malaria_Homo sapiens_hsa051440.48029521
83Phenylalanine metabolism_Homo sapiens_hsa003600.46104232
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45455740
85Staphylococcus aureus infection_Homo sapiens_hsa051500.44872022
86Fat digestion and absorption_Homo sapiens_hsa049750.44406880
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.43438094
88Mismatch repair_Homo sapiens_hsa034300.43366210
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.42018298
90Tyrosine metabolism_Homo sapiens_hsa003500.38964556
91Osteoclast differentiation_Homo sapiens_hsa043800.38788864
92Metabolic pathways_Homo sapiens_hsa011000.38606479
93Selenocompound metabolism_Homo sapiens_hsa004500.38451846
94Nucleotide excision repair_Homo sapiens_hsa034200.37096041
95Spliceosome_Homo sapiens_hsa030400.37074250
96Salivary secretion_Homo sapiens_hsa049700.35242985
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34984892
98Circadian rhythm_Homo sapiens_hsa047100.33913579
99Butanoate metabolism_Homo sapiens_hsa006500.32346626
100Epstein-Barr virus infection_Homo sapiens_hsa051690.30940822

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