RPS15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational termination (GO:0006415)9.87094814
2ribosomal small subunit assembly (GO:0000028)9.63642312
3* ribosomal small subunit biogenesis (GO:0042274)8.49743528
4* translational elongation (GO:0006414)8.44704119
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.16483273
6* protein targeting to ER (GO:0045047)8.01649824
7* cotranslational protein targeting to membrane (GO:0006613)8.00263110
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.81973360
9maturation of SSU-rRNA (GO:0030490)7.71097898
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.67226952
11* cellular protein complex disassembly (GO:0043624)7.66656471
12* viral life cycle (GO:0019058)7.63369842
13* protein localization to endoplasmic reticulum (GO:0070972)7.45093366
14* translational initiation (GO:0006413)7.29972331
15* protein complex disassembly (GO:0043241)6.82012815
16* macromolecular complex disassembly (GO:0032984)6.31923775
17ribosomal large subunit biogenesis (GO:0042273)6.11769532
18chaperone-mediated protein transport (GO:0072321)5.55404567
19* nuclear-transcribed mRNA catabolic process (GO:0000956)5.50463165
20* protein targeting to membrane (GO:0006612)5.40029398
21* mRNA catabolic process (GO:0006402)5.22092530
22respiratory electron transport chain (GO:0022904)4.91969075
23* RNA catabolic process (GO:0006401)4.88323006
24* translation (GO:0006412)4.82218381
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80763835
26electron transport chain (GO:0022900)4.79456521
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.69789471
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.66324449
29* ribonucleoprotein complex biogenesis (GO:0022613)4.59785326
30formation of translation preinitiation complex (GO:0001731)4.53718172
31regulation of mitochondrial translation (GO:0070129)4.29394234
32protein complex biogenesis (GO:0070271)4.09877312
33mitochondrial respiratory chain complex I assembly (GO:0032981)4.05926829
34NADH dehydrogenase complex assembly (GO:0010257)4.05926829
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05926829
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.98710735
37mitochondrial respiratory chain complex assembly (GO:0033108)3.89929149
38DNA unwinding involved in DNA replication (GO:0006268)3.71675429
39termination of RNA polymerase III transcription (GO:0006386)3.67756050
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.67756050
41ncRNA 3-end processing (GO:0043628)3.65287912
42* establishment of protein localization to membrane (GO:0090150)3.64472484
43* rRNA processing (GO:0006364)3.62915505
44negative regulation of RNA splicing (GO:0033119)3.61763804
45protein targeting to mitochondrion (GO:0006626)3.58922537
46GTP biosynthetic process (GO:0006183)3.55934011
47UTP biosynthetic process (GO:0006228)3.51152682
48* rRNA metabolic process (GO:0016072)3.49485729
49base-excision repair, AP site formation (GO:0006285)3.45992677
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.45128948
51establishment of protein localization to mitochondrion (GO:0072655)3.42074726
52ATP biosynthetic process (GO:0006754)3.41716823
53oxidative phosphorylation (GO:0006119)3.40576833
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.40053379
55guanosine-containing compound biosynthetic process (GO:1901070)3.35561778
56DNA strand elongation involved in DNA replication (GO:0006271)3.30596654
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.28596143
58deoxyribonucleotide catabolic process (GO:0009264)3.27097697
59pyrimidine nucleotide catabolic process (GO:0006244)3.25985858
60* establishment of protein localization to organelle (GO:0072594)3.25089142
61pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.25023284
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.23579090
63* protein targeting (GO:0006605)3.22848135
64protein neddylation (GO:0045116)3.22684026
65* cellular component biogenesis (GO:0044085)3.17424961
66protein localization to mitochondrion (GO:0070585)3.16382272
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.13493955
68UTP metabolic process (GO:0046051)3.13107616
69deoxyribose phosphate catabolic process (GO:0046386)3.12799299
70DNA deamination (GO:0045006)3.11540595
71DNA strand elongation (GO:0022616)3.09951806
72protein localization to kinetochore (GO:0034501)3.08438429
73telomere maintenance via semi-conservative replication (GO:0032201)3.06061324
74inner mitochondrial membrane organization (GO:0007007)3.04775447
75purine deoxyribonucleotide catabolic process (GO:0009155)3.02747463
76rRNA modification (GO:0000154)3.02541214
77CTP metabolic process (GO:0046036)3.01315764
78CTP biosynthetic process (GO:0006241)3.01315764
79pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00896929
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99252471
81hydrogen ion transmembrane transport (GO:1902600)2.99130639
82* cellular component disassembly (GO:0022411)2.94388814
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.94056992
84establishment of integrated proviral latency (GO:0075713)2.92136335
85DNA replication initiation (GO:0006270)2.90681892
86transcription-coupled nucleotide-excision repair (GO:0006283)2.89934447
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89388780
88nucleoside triphosphate biosynthetic process (GO:0009142)2.88756592
89regulation of protein heterodimerization activity (GO:0043497)2.86425488
90proteasome assembly (GO:0043248)2.84821072
91negative regulation of ligase activity (GO:0051352)2.81485105
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81485105
93spliceosomal snRNP assembly (GO:0000387)2.79899033
94mitochondrial transport (GO:0006839)2.78466186
95pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75508762
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75122570
97spliceosomal complex assembly (GO:0000245)2.74666174
98purine nucleoside monophosphate biosynthetic process (GO:0009127)2.74541781
99purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.74541781
100cytochrome complex assembly (GO:0017004)2.73659786
101ribosome biogenesis (GO:0042254)2.71782622
1022-deoxyribonucleotide metabolic process (GO:0009394)2.71540474
103* protein localization to membrane (GO:0072657)2.70627071
104folic acid-containing compound biosynthetic process (GO:0009396)2.69876594
105* gene expression (GO:0010467)2.67244228
106mRNA splicing, via spliceosome (GO:0000398)2.66508017
107RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66508017
108protein localization to chromosome, centromeric region (GO:0071459)2.66123802
109RNA splicing, via transesterification reactions (GO:0000375)2.64054807
110negative regulation of mRNA processing (GO:0050686)2.62863743
111termination of RNA polymerase II transcription (GO:0006369)2.59763708
112ATP synthesis coupled proton transport (GO:0015986)2.56430594
113energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56430594
114telomere maintenance via recombination (GO:0000722)2.55920083
115ribonucleoprotein complex assembly (GO:0022618)2.54707393
116mitotic nuclear envelope disassembly (GO:0007077)2.54700187
117regulation of translational fidelity (GO:0006450)2.54613176
118T cell apoptotic process (GO:0070231)2.47812672
119mitotic recombination (GO:0006312)2.45796528
120* protein localization to organelle (GO:0033365)2.42261472
121ribosome assembly (GO:0042255)2.40639306
122telomere maintenance via telomere lengthening (GO:0010833)2.39669241
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.38910443
124ribonucleoprotein complex subunit organization (GO:0071826)2.38720875
125IMP biosynthetic process (GO:0006188)2.38391402
126heterochromatin organization (GO:0070828)2.37055514
127pseudouridine synthesis (GO:0001522)2.36768425
128DNA replication-dependent nucleosome organization (GO:0034723)2.36708060
129DNA replication-dependent nucleosome assembly (GO:0006335)2.36708060
130* ncRNA processing (GO:0034470)2.36147640
131negative regulation of mRNA metabolic process (GO:1903312)2.34765319
1323-UTR-mediated mRNA stabilization (GO:0070935)2.34240043
133regulation of histone H3-K9 methylation (GO:0051570)2.32890181
134regulation of gene silencing by RNA (GO:0060966)2.32464621
135regulation of posttranscriptional gene silencing (GO:0060147)2.32464621
136regulation of gene silencing by miRNA (GO:0060964)2.32464621
137nucleobase biosynthetic process (GO:0046112)2.31726500
138nuclear envelope disassembly (GO:0051081)2.31283171
139membrane disassembly (GO:0030397)2.31283171
140mitotic sister chromatid segregation (GO:0000070)2.26818324
141DNA replication checkpoint (GO:0000076)2.25668698
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.22778287
143peptidyl-arginine omega-N-methylation (GO:0035247)2.22669538
144alternative mRNA splicing, via spliceosome (GO:0000380)2.22337503
145establishment of viral latency (GO:0019043)2.21329634
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20467822
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.20467822
148negative regulation of histone methylation (GO:0031061)2.19012430
149lymphocyte apoptotic process (GO:0070227)2.18856138
150DNA duplex unwinding (GO:0032508)2.18715548
151kinetochore organization (GO:0051383)2.16838593
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.16330444
153regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.16204740
154DNA geometric change (GO:0032392)2.15431695
155* viral transcription (GO:0019083)10.3302243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.98089740
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.34527769
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10858999
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.50025638
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.46338348
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.37451375
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.85143597
8XRN2_22483619_ChIP-Seq_HELA_Human2.66689461
9MYC_22102868_ChIP-Seq_BL_Human2.61085348
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.59450967
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58789059
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57852599
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55466198
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51756041
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51114188
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.50363025
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.25851855
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18368935
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12141971
20* VDR_21846776_ChIP-Seq_THP-1_Human2.06772448
21* TTF2_22483619_ChIP-Seq_HELA_Human1.97106803
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95058248
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91338007
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90967930
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90292812
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85810812
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.83682665
28* VDR_23849224_ChIP-Seq_CD4+_Human1.81423804
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79605802
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79425586
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77421736
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74697157
33DCP1A_22483619_ChIP-Seq_HELA_Human1.67325106
34CIITA_25753668_ChIP-Seq_RAJI_Human1.66633871
35FOXP3_21729870_ChIP-Seq_TREG_Human1.63355660
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63311325
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.62856841
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55781977
39* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47174323
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.46125087
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45175079
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42476515
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41721109
44* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40464621
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40381165
46* GABP_19822575_ChIP-Seq_HepG2_Human1.38592062
47ELK1_19687146_ChIP-ChIP_HELA_Human1.37759749
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36862212
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35793887
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.34970266
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34353661
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34136539
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33149515
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32266398
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31873451
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31105784
57AR_21909140_ChIP-Seq_LNCAP_Human1.28822087
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27994092
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.25718438
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25569951
61* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25246290
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24193411
63UTX_26944678_Chip-Seq_JUKART_Human1.24088879
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23757232
65KDM5A_27292631_Chip-Seq_BREAST_Human1.22862064
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22781488
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22551871
68P68_20966046_ChIP-Seq_HELA_Human1.22170849
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21941097
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21114954
71* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20931907
72MAF_26560356_Chip-Seq_TH1_Human1.20205054
73LXR_22292898_ChIP-Seq_THP-1_Human1.19990215
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19827491
75* ELF1_20517297_ChIP-Seq_JURKAT_Human1.16920007
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16912829
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16860782
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16851931
79ZNF263_19887448_ChIP-Seq_K562_Human1.15888956
80* CTCF_26484167_Chip-Seq_Bcells_Mouse1.15821186
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.14734004
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14609003
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.14172023
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14152411
85TCF7_22412390_ChIP-Seq_EML_Mouse1.13424965
86* MAF_26560356_Chip-Seq_TH2_Human1.13208119
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12079068
88BCL6_27268052_Chip-Seq_Bcells_Human1.11852762
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11574549
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11194547
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09379933
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08990324
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08730476
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07938645
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.07931630
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07858282
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06055990
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.05803503
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05617316
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05518966
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.04273143
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02455967
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01972401
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01836232
105VDR_24763502_ChIP-Seq_THP-1_Human1.00900024
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00610965
107* SPI1_23547873_ChIP-Seq_NB4_Human0.98556348
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98267163
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.98106038
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97528874
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96252425
112SCL_19346495_ChIP-Seq_HPC-7_Human0.94864136
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93674619
114ATF3_27146783_Chip-Seq_COLON_Human0.92854904
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92574821
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92314832
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.92222759
118RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91906530
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91482891
120BCOR_27268052_Chip-Seq_Bcells_Human0.90400087
121KDM2B_26808549_Chip-Seq_DND41_Human0.90090124
122TFEB_21752829_ChIP-Seq_HELA_Human0.89217713
123MYC_18940864_ChIP-ChIP_HL60_Human0.88912761
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88632350
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87655123
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87571403
127* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87310750
128SA1_27219007_Chip-Seq_Bcells_Human0.87307896
129* E2F1_20622854_ChIP-Seq_HELA_Human0.87118913
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86605240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.14018766
2MP0009379_abnormal_foot_pigmentation3.79124242
3MP0003693_abnormal_embryo_hatching3.61954663
4MP0004957_abnormal_blastocyst_morpholog3.29447944
5MP0003077_abnormal_cell_cycle2.78079004
6MP0003111_abnormal_nucleus_morphology2.75226404
7MP0010094_abnormal_chromosome_stability2.50875470
8MP0010352_gastrointestinal_tract_polyps2.28954063
9MP0002396_abnormal_hematopoietic_system2.25649747
10MP0003186_abnormal_redox_activity2.24869138
11MP0002163_abnormal_gland_morphology2.24677853
12MP0003136_yellow_coat_color2.18635655
13MP0002653_abnormal_ependyma_morphology2.05859230
14MP0008057_abnormal_DNA_replication2.00388905
15MP0003763_abnormal_thymus_physiology1.94581804
16MP0006036_abnormal_mitochondrial_physio1.87390108
17MP0000490_abnormal_crypts_of1.84629627
18MP0003806_abnormal_nucleotide_metabolis1.81229016
19MP0004808_abnormal_hematopoietic_stem1.77595597
20MP0008007_abnormal_cellular_replicative1.76035195
21MP0009333_abnormal_splenocyte_physiolog1.74533420
22MP0001730_embryonic_growth_arrest1.73658065
23MP0000566_synostosis1.73180612
24MP0000350_abnormal_cell_proliferation1.72611698
25MP0010030_abnormal_orbit_morphology1.71271472
26MP0008789_abnormal_olfactory_epithelium1.70926773
27MP0003705_abnormal_hypodermis_morpholog1.69899153
28MP0002938_white_spotting1.66899010
29MP0001346_abnormal_lacrimal_gland1.65526912
30MP0008932_abnormal_embryonic_tissue1.65098096
31MP0002277_abnormal_respiratory_mucosa1.61044753
32MP0000537_abnormal_urethra_morphology1.60243372
33MP0002796_impaired_skin_barrier1.52619417
34MP0000372_irregular_coat_pigmentation1.51370522
35MP0000685_abnormal_immune_system1.49843338
36MP0000703_abnormal_thymus_morphology1.49606363
37MP0005501_abnormal_skin_physiology1.49070657
38MP0003123_paternal_imprinting1.45957472
39MP0003567_abnormal_fetal_cardiomyocyte1.44463417
40MP0005499_abnormal_olfactory_system1.43314154
41MP0005394_taste/olfaction_phenotype1.43314154
42MP0006054_spinal_hemorrhage1.41861450
43MP0009278_abnormal_bone_marrow1.40431070
44MP0003786_premature_aging1.39912326
45MP0002398_abnormal_bone_marrow1.39086703
46MP0005076_abnormal_cell_differentiation1.38548208
47MP0006035_abnormal_mitochondrial_morpho1.38038876
48MP0002722_abnormal_immune_system1.34305966
49MP0003938_abnormal_ear_development1.29443903
50MP0003941_abnormal_skin_development1.29113238
51MP0004197_abnormal_fetal_growth/weight/1.29043395
52MP0005023_abnormal_wound_healing1.28838895
53MP0005397_hematopoietic_system_phenotyp1.27985149
54MP0001545_abnormal_hematopoietic_system1.27985149
55MP0002019_abnormal_tumor_incidence1.27549839
56MP0001697_abnormal_embryo_size1.27324585
57MP0008058_abnormal_DNA_repair1.26611719
58MP0003566_abnormal_cell_adhesion1.26588880
59MP0002080_prenatal_lethality1.26265431
60MP0010234_abnormal_vibrissa_follicle1.24389677
61MP0002085_abnormal_embryonic_tissue1.21911890
62MP0000858_altered_metastatic_potential1.21116713
63MP0001800_abnormal_humoral_immune1.19582110
64MP0002160_abnormal_reproductive_system1.18480472
65MP0000313_abnormal_cell_death1.17478270
66MP0005380_embryogenesis_phenotype1.17255156
67MP0001672_abnormal_embryogenesis/_devel1.17255156
68MP0002084_abnormal_developmental_patter1.16504739
69MP0000689_abnormal_spleen_morphology1.16397809
70MP0000678_abnormal_parathyroid_gland1.14166282
71MP0005083_abnormal_biliary_tract1.13893008
72MP0005670_abnormal_white_adipose1.11998928
73MP0005075_abnormal_melanosome_morpholog1.10807632
74MP0002086_abnormal_extraembryonic_tissu1.10735549
75MP0002095_abnormal_skin_pigmentation1.10049596
76MP0001905_abnormal_dopamine_level1.08649706
77MP0002166_altered_tumor_susceptibility1.08584261
78MP0002088_abnormal_embryonic_growth/wei1.08543527
79MP0003984_embryonic_growth_retardation1.08417025
80MP0002210_abnormal_sex_determination1.08322460
81MP0002429_abnormal_blood_cell1.08242828
82MP0000750_abnormal_muscle_regeneration1.07877998
83MP0009053_abnormal_anal_canal1.06861299
84MP0004142_abnormal_muscle_tone1.06706871
85MP0001529_abnormal_vocalization1.05225229
86MP0010307_abnormal_tumor_latency1.05201523
87MP0003011_delayed_dark_adaptation1.05110195
88MP0000465_gastrointestinal_hemorrhage1.04094681
89MP0000716_abnormal_immune_system1.03283433
90MP0002060_abnormal_skin_morphology1.02817880
91MP0001849_ear_inflammation1.02350858
92MP0001216_abnormal_epidermal_layer1.01333535
93MP0000631_abnormal_neuroendocrine_gland0.99131303
94MP0002420_abnormal_adaptive_immunity0.97699312
95MP0000733_abnormal_muscle_development0.97375191
96MP0002405_respiratory_system_inflammati0.96956785
97MP0003453_abnormal_keratinocyte_physiol0.95364321
98MP0001819_abnormal_immune_cell0.94772722
99MP0005174_abnormal_tail_pigmentation0.94573941
100MP0002452_abnormal_antigen_presenting0.93593212
101MP0010155_abnormal_intestine_physiology0.89833208
102MP0000477_abnormal_intestine_morphology0.89637682
103MP0003718_maternal_effect0.89554307
104MP0003315_abnormal_perineum_morphology0.89326057
105MP0002249_abnormal_larynx_morphology0.88663635
106MP0002234_abnormal_pharynx_morphology0.88624927
107MP0002132_abnormal_respiratory_system0.88575450
108MP0001873_stomach_inflammation0.88412624
109MP0001145_abnormal_male_reproductive0.87592655
110MP0005275_abnormal_skin_tensile0.86957301
111MP0002111_abnormal_tail_morphology0.86890732
112MP0002098_abnormal_vibrissa_morphology0.86173179
113MP0003866_abnormal_defecation0.86058866
114MP0004381_abnormal_hair_follicle0.85942382
115MP0001764_abnormal_homeostasis0.85663249
116MP0001293_anophthalmia0.85286653
117MP0001835_abnormal_antigen_presentation0.84718629
118MP0004947_skin_inflammation0.84624316
119MP0005671_abnormal_response_to0.84126067
120MP0003119_abnormal_digestive_system0.83546519
121MP0009931_abnormal_skin_appearance0.82246804
122MP0000377_abnormal_hair_follicle0.81201189
123MP0001853_heart_inflammation0.81017645
124MP0002723_abnormal_immune_serum0.80765814
125MP0002282_abnormal_trachea_morphology0.80296358
126MP0003878_abnormal_ear_physiology0.80233114
127MP0005377_hearing/vestibular/ear_phenot0.80233114
128MP0003300_gastrointestinal_ulcer0.78868404
129MP0005379_endocrine/exocrine_gland_phen0.78554157
130MP0002006_tumorigenesis0.78377729
131MP0001919_abnormal_reproductive_system0.77743986
132MP0000762_abnormal_tongue_morphology0.77685258
133MP0005389_reproductive_system_phenotype0.77493378
134MP0002822_catalepsy0.76770146
135MP0008995_early_reproductive_senescence0.76668300
136MP0008770_decreased_survivor_rate0.76294368
137MP0002932_abnormal_joint_morphology0.76127021
138MP0002697_abnormal_eye_size0.74402912
139MP0009250_abnormal_appendicular_skeleto0.74219426
140MP0000049_abnormal_middle_ear0.73954825
141MP0000653_abnormal_sex_gland0.73498712
142MP0005000_abnormal_immune_tolerance0.73302056
143MP0001929_abnormal_gametogenesis0.66962406
144MP0001286_abnormal_eye_development0.66901516
145MP0001986_abnormal_taste_sensitivity0.66112133
146MP0001188_hyperpigmentation0.65829286
147MP0003942_abnormal_urinary_system0.63227936
148MP0000026_abnormal_inner_ear0.63099520
149MP0004185_abnormal_adipocyte_glucose0.62721768
150MP0008961_abnormal_basal_metabolism0.61119097
151MP0000681_abnormal_thyroid_gland0.60803304
152MP0004742_abnormal_vestibular_system0.60090813
153MP0006072_abnormal_retinal_apoptosis0.59932788
154MP0001881_abnormal_mammary_gland0.59808662
155MP0000358_abnormal_cell_content/0.59660535
156MP0004858_abnormal_nervous_system0.59349808
157MP0002837_dystrophic_cardiac_calcinosis0.57966742
158MP0005084_abnormal_gallbladder_morpholo0.56836559

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.13194823
2Abnormal number of erythroid precursors (HP:0012131)8.05370037
3Reticulocytopenia (HP:0001896)7.99943244
4Macrocytic anemia (HP:0001972)5.81882953
5Acute necrotizing encephalopathy (HP:0006965)5.59932608
6Pallor (HP:0000980)5.46818389
7Abnormal mitochondria in muscle tissue (HP:0008316)5.42332143
8Mitochondrial inheritance (HP:0001427)5.28690614
9Acute encephalopathy (HP:0006846)4.79172825
10Hepatocellular necrosis (HP:0001404)4.65002759
11Increased hepatocellular lipid droplets (HP:0006565)4.55065615
12Increased CSF lactate (HP:0002490)4.48698821
13Progressive macrocephaly (HP:0004481)4.31661470
14Increased intramyocellular lipid droplets (HP:0012240)4.29119332
15Lipid accumulation in hepatocytes (HP:0006561)4.17530218
16Hepatic necrosis (HP:0002605)4.11205474
17Renal Fanconi syndrome (HP:0001994)3.88100399
18Increased muscle lipid content (HP:0009058)3.84433503
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81546790
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81546790
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.69142035
22Cerebral edema (HP:0002181)3.62134694
23Colon cancer (HP:0003003)3.47583406
24Thrombocytosis (HP:0001894)3.45959650
25Respiratory difficulties (HP:0002880)3.30053614
26Microvesicular hepatic steatosis (HP:0001414)3.12296139
27Exercise intolerance (HP:0003546)3.10568657
28Lactic acidosis (HP:0003128)3.07658275
29Abnormality of reticulocytes (HP:0004312)3.04556840
303-Methylglutaconic aciduria (HP:0003535)2.95174062
31Selective tooth agenesis (HP:0001592)2.95129029
32Exertional dyspnea (HP:0002875)2.92254150
33Increased serum lactate (HP:0002151)2.90993396
34Trismus (HP:0000211)2.87071819
35Abnormal hemoglobin (HP:0011902)2.86660104
36Respiratory failure (HP:0002878)2.77675920
3711 pairs of ribs (HP:0000878)2.74695912
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70612094
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70216760
40Multiple enchondromatosis (HP:0005701)2.67440673
41Absent thumb (HP:0009777)2.65644156
42Aplastic anemia (HP:0001915)2.61168868
43IgM deficiency (HP:0002850)2.48902399
44Leukodystrophy (HP:0002415)2.48267196
45Depressed nasal ridge (HP:0000457)2.46301460
46Testicular atrophy (HP:0000029)2.44728120
47Optic disc pallor (HP:0000543)2.43632072
48Broad distal phalanx of finger (HP:0009836)2.40463209
49Pancytopenia (HP:0001876)2.37083954
50Stenosis of the external auditory canal (HP:0000402)2.35647614
51Woolly hair (HP:0002224)2.35042894
52Basal cell carcinoma (HP:0002671)2.31983169
53Oral leukoplakia (HP:0002745)2.29733888
54Thick lower lip vermilion (HP:0000179)2.29390767
55Missing ribs (HP:0000921)2.28243212
56Asplenia (HP:0001746)2.19500306
57Abnormal number of incisors (HP:0011064)2.19330841
58Septo-optic dysplasia (HP:0100842)2.19137286
59Migraine (HP:0002076)2.16488602
60Abnormality of renal resorption (HP:0011038)2.14115634
61Progressive muscle weakness (HP:0003323)2.13342203
62Atresia of the external auditory canal (HP:0000413)2.08431646
63Type I transferrin isoform profile (HP:0003642)2.07846258
64Rectal prolapse (HP:0002035)2.07562294
65Rib fusion (HP:0000902)2.06325745
66Congenital, generalized hypertrichosis (HP:0004540)2.04818107
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.03127135
68Hyperacusis (HP:0010780)2.01179115
69Carpal bone hypoplasia (HP:0001498)1.99622273
70Chronic otitis media (HP:0000389)1.99587017
71Emotional lability (HP:0000712)1.99402180
72Fragile nails (HP:0001808)1.97461858
73Neoplasm of the pancreas (HP:0002894)1.94893818
74Verrucae (HP:0200043)1.91564929
75Papilloma (HP:0012740)1.91564929
76Mesangial abnormality (HP:0001966)1.91397752
77Glossoptosis (HP:0000162)1.91149437
78Bicuspid aortic valve (HP:0001647)1.89989122
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89159206
80Proximal placement of thumb (HP:0009623)1.88432294
81Partial duplication of the phalanx of hand (HP:0009999)1.87921312
82Rough bone trabeculation (HP:0100670)1.87074651
83Ependymoma (HP:0002888)1.85306889
84Protrusio acetabuli (HP:0003179)1.85200570
85Lethargy (HP:0001254)1.84228063
86Microretrognathia (HP:0000308)1.83196425
87Nasal polyposis (HP:0100582)1.82857585
88Hypoplasia of the radius (HP:0002984)1.81838705
89Hyperphosphaturia (HP:0003109)1.81091410
90Partial duplication of thumb phalanx (HP:0009944)1.81086565
91Duplication of thumb phalanx (HP:0009942)1.80622463
92Increased density of long bones (HP:0006392)1.80546400
93Breast hypoplasia (HP:0003187)1.79654768
94Patellar aplasia (HP:0006443)1.79258965
95Deviation of the thumb (HP:0009603)1.77817907
96Recurrent bronchitis (HP:0002837)1.76789654
97Ragged-red muscle fibers (HP:0003200)1.76170572
98Squamous cell carcinoma (HP:0002860)1.76125892
99Pili torti (HP:0003777)1.75040284
100Aplasia/Hypoplasia of the patella (HP:0006498)1.74535563
101Abnormality of the nasal mucosa (HP:0000433)1.74115399
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74061693
103Dicarboxylic aciduria (HP:0003215)1.74061693
104Abnormality of the parietal bone (HP:0002696)1.72141966
105Triphalangeal thumb (HP:0001199)1.71804272
106Abnormality of the anterior horn cell (HP:0006802)1.70455267
107Degeneration of anterior horn cells (HP:0002398)1.70455267
108Hyperglycinemia (HP:0002154)1.69891386
109Petechiae (HP:0000967)1.68985580
110Adenoma sebaceum (HP:0009720)1.68262406
111Angiofibromas (HP:0010615)1.68262406
112Cellulitis (HP:0100658)1.67624507
113Abnormality of urine glucose concentration (HP:0011016)1.67602879
114Glycosuria (HP:0003076)1.67602879
115Myelodysplasia (HP:0002863)1.67479381
116Esophageal atresia (HP:0002032)1.67460063
117Sparse lateral eyebrow (HP:0005338)1.67346205
118Nasolacrimal duct obstruction (HP:0000579)1.66959129
119Muscle fiber atrophy (HP:0100295)1.66649956
120Maternal diabetes (HP:0009800)1.65418541
121Agammaglobulinemia (HP:0004432)1.64039743
122Myokymia (HP:0002411)1.63935021
123Skin tags (HP:0010609)1.61267388
124Down-sloping shoulders (HP:0200021)1.61097452
125Preauricular skin tag (HP:0000384)1.59327402
126Hyperthyroidism (HP:0000836)1.58300975
127Milia (HP:0001056)1.57991204
128Poikiloderma (HP:0001029)1.57574426
129CNS demyelination (HP:0007305)1.56565757
130Panhypogammaglobulinemia (HP:0003139)1.56483924
131Cleft eyelid (HP:0000625)1.55724571
132Progressive microcephaly (HP:0000253)1.55157031
133Elevated erythrocyte sedimentation rate (HP:0003565)1.54680875
134Optic nerve coloboma (HP:0000588)1.54680475
135X-linked dominant inheritance (HP:0001423)1.53827880
136Tracheoesophageal fistula (HP:0002575)1.53458519
137Horseshoe kidney (HP:0000085)1.52351745
138Sclerocornea (HP:0000647)1.51258680
139Ulnar bowing (HP:0003031)1.50600277
140Vertebral hypoplasia (HP:0008417)1.50124739
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.50124739
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.49727167
143Abnormal protein N-linked glycosylation (HP:0012347)1.49727167
144Abnormal protein glycosylation (HP:0012346)1.49727167
145Abnormal glycosylation (HP:0012345)1.49727167
146Gastrointestinal inflammation (HP:0004386)1.48903069
147Neutropenia (HP:0001875)1.48348692
148Truncus arteriosus (HP:0001660)1.48213591
149Forearm undergrowth (HP:0009821)1.48170848
150Cellular immunodeficiency (HP:0005374)1.48163034
151Abnormality of the fetal cardiovascular system (HP:0010948)1.48093885
152Abnormal umbilical cord blood vessels (HP:0011403)1.48093885
153Single umbilical artery (HP:0001195)1.48093885
154Abnormality of T cells (HP:0002843)1.47123698
155Abnormality of the umbilical cord (HP:0010881)1.46929795
156Seborrheic dermatitis (HP:0001051)1.46607903
157Abnormality of the calcaneus (HP:0008364)1.45907884
158Increased nuchal translucency (HP:0010880)1.45676633
159Premature ovarian failure (HP:0008209)1.45108884
160Aplasia/Hypoplasia of the thymus (HP:0010515)1.43954102
161Pustule (HP:0200039)1.43629462
162Ankle contracture (HP:0006466)1.42291725
163Concave nail (HP:0001598)1.41365892
164Short thumb (HP:0009778)1.40812278
165High pitched voice (HP:0001620)1.40399900
166Premature graying of hair (HP:0002216)1.40382918
167Birth length less than 3rd percentile (HP:0003561)1.40075974
168Lymphoma (HP:0002665)1.40074467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.28932610
2EEF2K4.46542764
3NME24.21140107
4MAP3K103.13615463
5BUB13.00162574
6RPS6KB22.90939164
7BCKDK2.73087823
8MAP4K12.60510581
9PKN22.54570951
10WEE12.51710992
11TRIB32.27463243
12SMG12.27009535
13CDC72.11203575
14TGFBR11.98362496
15TAF11.93995348
16NEK21.88212498
17PASK1.86130928
18* LRRK21.82966398
19TLK11.82796052
20ZAK1.77515808
21ARAF1.75044963
22STK101.71912308
23PIM21.66316031
24ILK1.59264802
25GRK61.58708181
26SRPK11.58016991
27RPS6KA41.57978593
28DYRK31.51393753
29DYRK21.47459180
30TESK21.45242222
31CCNB11.42172384
32CDK191.37966816
33CDK71.36032662
34PAK41.35599304
35EPHA21.35006323
36AURKB1.33570012
37MAPKAPK31.31998626
38TSSK61.26531500
39MST41.26304944
40MAP3K81.25361849
41CDK81.19875565
42CDK41.18363283
43PIM11.14797966
44NUAK11.13945252
45KDR1.13857271
46ABL21.11841752
47BRAF1.11277064
48SCYL21.10552824
49BTK1.08246394
50PBK1.06737179
51VRK11.04890992
52ERN11.04849065
53CDK120.97393275
54FLT30.96913225
55MKNK10.95726521
56TTK0.95081280
57PLK10.91704471
58MAP2K30.88479277
59TTN0.88368405
60PLK40.85549947
61STK40.84079267
62AURKA0.83877837
63PAK20.83578838
64ATR0.83567675
65ZAP700.83189084
66BRSK10.80949599
67BLK0.79564210
68LIMK10.79388840
69MAP2K20.75433633
70NME10.74551784
71IRAK30.72748683
72ALK0.72341010
73IRAK40.71485935
74EIF2AK10.71322523
75PTK60.71264495
76CSNK2A20.70348351
77CHEK10.70238980
78CDK60.69382078
79TYK20.68842673
80BMX0.68074692
81NEK10.67482803
82TAOK20.66366174
83MAP3K110.65406165
84PAK10.65041092
85MAP3K30.64049268
86BRSK20.63817766
87RPS6KA50.63478451
88DAPK30.63004034
89JAK30.62678117
90TXK0.61494656
91CLK10.59780868
92STK160.58056775
93MARK30.57542087
94IKBKB0.56724019
95MTOR0.56378938
96PDK20.55347519
97DAPK10.55290023
98TESK10.54239761
99CSF1R0.54190875
100SYK0.53064327
101EPHB20.52332012
102CHEK20.51087152
103CDK20.50890565
104RPS6KC10.50448620
105RPS6KL10.50448620
106PRPF4B0.49670555
107CAMKK10.48206878
108MUSK0.48133872
109DYRK1B0.47648114
110RPS6KA60.46917827
111AKT20.46544121
112PRKCI0.46147162
113RPS6KA10.45860691
114EIF2AK30.45826151
115CSNK2A10.45535214
116TGFBR20.45322347
117TNK20.44792423
118MAPKAPK20.44704548
119CSNK1G30.44682676
120LCK0.42520823
121ACVR1B0.39458781
122ITK0.38907260
123KIT0.36869655
124MST1R0.36546284
125ATM0.36178220
126IRAK20.35514489
127MAPKAPK50.34557883
128TAOK10.34145863
129CDK11A0.33194287
130HCK0.32471165
131CAMK10.31887669
132CSNK1E0.31309864
133WNK40.29600333
134HIPK20.26710891
135ICK0.26513220
136CDK10.26169595
137PRKCQ0.23906874
138FES0.23690396
139PRKD30.23316738
140CDK90.22562289
141PRKCD0.21336006

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.04066967
2DNA replication_Homo sapiens_hsa030303.64788205
3Spliceosome_Homo sapiens_hsa030403.28865437
4Mismatch repair_Homo sapiens_hsa034303.03155160
5Proteasome_Homo sapiens_hsa030502.57271900
6RNA polymerase_Homo sapiens_hsa030202.57148998
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47914571
8RNA transport_Homo sapiens_hsa030132.35544428
9Base excision repair_Homo sapiens_hsa034102.18446077
10Nucleotide excision repair_Homo sapiens_hsa034202.04583511
11Homologous recombination_Homo sapiens_hsa034401.95042317
12Cardiac muscle contraction_Homo sapiens_hsa042601.87404348
13Pyrimidine metabolism_Homo sapiens_hsa002401.87354412
14One carbon pool by folate_Homo sapiens_hsa006701.78485020
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74581046
16Cell cycle_Homo sapiens_hsa041101.71777690
17Primary immunodeficiency_Homo sapiens_hsa053401.55818718
18p53 signaling pathway_Homo sapiens_hsa041151.41969408
19RNA degradation_Homo sapiens_hsa030181.40473487
20mRNA surveillance pathway_Homo sapiens_hsa030151.34194226
21Parkinsons disease_Homo sapiens_hsa050121.31965299
22Folate biosynthesis_Homo sapiens_hsa007901.30589583
23Antigen processing and presentation_Homo sapiens_hsa046121.22344154
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.18161520
25Fanconi anemia pathway_Homo sapiens_hsa034601.16735640
26Oxidative phosphorylation_Homo sapiens_hsa001901.14087322
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13571204
28Systemic lupus erythematosus_Homo sapiens_hsa053221.13250629
29Non-homologous end-joining_Homo sapiens_hsa034501.12967494
30Epstein-Barr virus infection_Homo sapiens_hsa051691.10775624
31Huntingtons disease_Homo sapiens_hsa050161.05134407
32Viral carcinogenesis_Homo sapiens_hsa052031.01170545
33Sulfur relay system_Homo sapiens_hsa041221.01031918
34HTLV-I infection_Homo sapiens_hsa051661.00732451
35Small cell lung cancer_Homo sapiens_hsa052220.96807173
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95195749
37Basal cell carcinoma_Homo sapiens_hsa052170.92543421
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90415148
39Notch signaling pathway_Homo sapiens_hsa043300.89483092
40Chronic myeloid leukemia_Homo sapiens_hsa052200.87671549
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86963401
42Herpes simplex infection_Homo sapiens_hsa051680.86812500
43Bladder cancer_Homo sapiens_hsa052190.84797021
44Fatty acid elongation_Homo sapiens_hsa000620.83690360
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83589477
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83049380
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.82059240
48Basal transcription factors_Homo sapiens_hsa030220.79380464
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78565974
50MicroRNAs in cancer_Homo sapiens_hsa052060.78564804
51Thyroid cancer_Homo sapiens_hsa052160.78076450
52B cell receptor signaling pathway_Homo sapiens_hsa046620.77227681
53Acute myeloid leukemia_Homo sapiens_hsa052210.76223021
54Alzheimers disease_Homo sapiens_hsa050100.75064950
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74665888
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73387641
57Pyruvate metabolism_Homo sapiens_hsa006200.72190865
58Purine metabolism_Homo sapiens_hsa002300.71788018
59Metabolic pathways_Homo sapiens_hsa011000.70876134
60Hematopoietic cell lineage_Homo sapiens_hsa046400.70411109
61Protein export_Homo sapiens_hsa030600.68509515
62Apoptosis_Homo sapiens_hsa042100.68438164
63Pentose phosphate pathway_Homo sapiens_hsa000300.66100488
64Carbon metabolism_Homo sapiens_hsa012000.65461702
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64079213
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59970831
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.59722931
68T cell receptor signaling pathway_Homo sapiens_hsa046600.58984961
69Shigellosis_Homo sapiens_hsa051310.55053372
70Pathways in cancer_Homo sapiens_hsa052000.54990389
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.54597430
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54524715
73Colorectal cancer_Homo sapiens_hsa052100.54379013
74Measles_Homo sapiens_hsa051620.54125634
75Hedgehog signaling pathway_Homo sapiens_hsa043400.53719766
76HIF-1 signaling pathway_Homo sapiens_hsa040660.52850976
77Proteoglycans in cancer_Homo sapiens_hsa052050.52335410
78Hippo signaling pathway_Homo sapiens_hsa043900.51484071
79Hepatitis B_Homo sapiens_hsa051610.51447900
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50680412
81Non-small cell lung cancer_Homo sapiens_hsa052230.48607448
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48153593
83Viral myocarditis_Homo sapiens_hsa054160.47966257
84Alcoholism_Homo sapiens_hsa050340.46094090
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45819591
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45573657
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45542875
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.45059906
89TGF-beta signaling pathway_Homo sapiens_hsa043500.43516311
90VEGF signaling pathway_Homo sapiens_hsa043700.42019524
91Phenylalanine metabolism_Homo sapiens_hsa003600.41616866
92ECM-receptor interaction_Homo sapiens_hsa045120.41269888
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.41112933
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.40703074
95Galactose metabolism_Homo sapiens_hsa000520.40542448
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40398102
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40230994
98Toxoplasmosis_Homo sapiens_hsa051450.38607082
99Legionellosis_Homo sapiens_hsa051340.38582281
100Platelet activation_Homo sapiens_hsa046110.38387357
101Tyrosine metabolism_Homo sapiens_hsa003500.37542455
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.35750134
103Adherens junction_Homo sapiens_hsa045200.35258688
104Glutathione metabolism_Homo sapiens_hsa004800.34221932
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34034983
106Leishmaniasis_Homo sapiens_hsa051400.33952536
107Fructose and mannose metabolism_Homo sapiens_hsa000510.33336301
108N-Glycan biosynthesis_Homo sapiens_hsa005100.33246986
109Peroxisome_Homo sapiens_hsa041460.33129436
110Biosynthesis of amino acids_Homo sapiens_hsa012300.30937982
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30730262
112Oocyte meiosis_Homo sapiens_hsa041140.30312950
113Asthma_Homo sapiens_hsa053100.30068666
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30011043
115Pancreatic cancer_Homo sapiens_hsa052120.29060119
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28458999
117Focal adhesion_Homo sapiens_hsa045100.28152096
118Arginine and proline metabolism_Homo sapiens_hsa003300.26704888
119Autoimmune thyroid disease_Homo sapiens_hsa053200.26652847
120Prostate cancer_Homo sapiens_hsa052150.26316486
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26315473
122Wnt signaling pathway_Homo sapiens_hsa043100.24970920
123Allograft rejection_Homo sapiens_hsa053300.24923833
124Osteoclast differentiation_Homo sapiens_hsa043800.24852222
125Arachidonic acid metabolism_Homo sapiens_hsa005900.22699107
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22143114
127Graft-versus-host disease_Homo sapiens_hsa053320.21919878
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21537465
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21281962
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19384480
131Sulfur metabolism_Homo sapiens_hsa009200.17810344
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16959822
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16473142
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16321004
135Phototransduction_Homo sapiens_hsa047440.14054717
136Collecting duct acid secretion_Homo sapiens_hsa049660.12397552
137Vitamin digestion and absorption_Homo sapiens_hsa049770.12224631
138Fat digestion and absorption_Homo sapiens_hsa049750.11901402
139Linoleic acid metabolism_Homo sapiens_hsa005910.08380696
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06374248
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05604699
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05604662
143Propanoate metabolism_Homo sapiens_hsa006400.05444281
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05402674
145Selenocompound metabolism_Homo sapiens_hsa004500.01472535
146Regulation of autophagy_Homo sapiens_hsa041400.00511703
147Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0152699

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