RPS15AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.46802031
2viral transcription (GO:0019083)7.29513667
3translational termination (GO:0006415)6.94634953
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.03793289
5translational elongation (GO:0006414)6.01352682
6protein targeting to ER (GO:0045047)5.94372343
7cotranslational protein targeting to membrane (GO:0006613)5.92800942
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.71266897
9protein localization to endoplasmic reticulum (GO:0070972)5.65864490
10DNA deamination (GO:0045006)5.39062507
11viral life cycle (GO:0019058)5.31116997
12cellular protein complex disassembly (GO:0043624)5.27720448
13cytidine deamination (GO:0009972)5.22381017
14cytidine metabolic process (GO:0046087)5.22381017
15cytidine catabolic process (GO:0006216)5.22381017
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10018180
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.06584015
18ATP synthesis coupled proton transport (GO:0015986)5.00444123
19energy coupled proton transport, down electrochemical gradient (GO:0015985)5.00444123
20ribosomal small subunit biogenesis (GO:0042274)4.99944517
21maturation of SSU-rRNA (GO:0030490)4.81557191
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68289073
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.64506468
24translational initiation (GO:0006413)4.48203697
25protein neddylation (GO:0045116)4.38999640
26protein complex disassembly (GO:0043241)4.28906907
27macromolecular complex disassembly (GO:0032984)4.01862880
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00565765
29protein targeting to membrane (GO:0006612)3.97779669
30respiratory electron transport chain (GO:0022904)3.86013740
31ribosomal large subunit biogenesis (GO:0042273)3.83971258
32electron transport chain (GO:0022900)3.82613152
33translation (GO:0006412)3.81175197
34positive regulation of respiratory burst (GO:0060267)3.69510590
35behavioral response to nicotine (GO:0035095)3.66707002
36sequestering of actin monomers (GO:0042989)3.53694723
37protein complex biogenesis (GO:0070271)3.51590423
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.49307076
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.37688904
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35520923
41GTP biosynthetic process (GO:0006183)3.34395040
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33021266
43mRNA catabolic process (GO:0006402)3.28294370
44negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.25603051
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22793705
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.22793705
47NADH dehydrogenase complex assembly (GO:0010257)3.22793705
48regulation of regulatory T cell differentiation (GO:0045589)3.17611492
49mitochondrial respiratory chain complex assembly (GO:0033108)3.12989086
50platelet dense granule organization (GO:0060155)3.08696573
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.06047229
52axoneme assembly (GO:0035082)3.02783394
53RNA catabolic process (GO:0006401)3.01958897
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00668983
55DNA demethylation (GO:0080111)3.00310812
56response to pheromone (GO:0019236)2.97688348
57ATP biosynthetic process (GO:0006754)2.97095289
58hydrogen ion transmembrane transport (GO:1902600)2.95577918
59water-soluble vitamin biosynthetic process (GO:0042364)2.92797982
60pyrimidine nucleotide catabolic process (GO:0006244)2.89756184
61regulation of respiratory burst (GO:0060263)2.82548895
62UTP biosynthetic process (GO:0006228)2.81988088
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77826871
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77826871
65proton transport (GO:0015992)2.75997277
66DNA dealkylation (GO:0035510)2.73858758
67cellular component biogenesis (GO:0044085)2.73098926
68establishment of protein localization to membrane (GO:0090150)2.71876094
69pyrimidine nucleoside catabolic process (GO:0046135)2.68656095
70hydrogen transport (GO:0006818)2.67443130
71antibacterial humoral response (GO:0019731)2.67118607
72negative regulation of mast cell activation (GO:0033004)2.66944595
73eosinophil chemotaxis (GO:0048245)2.65890885
74positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.65121826
75disruption of cells of other organism (GO:0044364)2.64574366
76killing of cells of other organism (GO:0031640)2.64574366
77regulation of isotype switching to IgG isotypes (GO:0048302)2.61740449
78ribonucleoprotein complex biogenesis (GO:0022613)2.61689182
79neuron fate determination (GO:0048664)2.56860853
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.56590313
81UTP metabolic process (GO:0046051)2.53286819
82pyrimidine ribonucleoside metabolic process (GO:0046131)2.51948784
83somite development (GO:0061053)2.49330577
84phosphatidylserine acyl-chain remodeling (GO:0036150)2.46163791
85positive regulation of defense response to virus by host (GO:0002230)2.46058873
86antimicrobial humoral response (GO:0019730)2.45478315
87mannosylation (GO:0097502)2.45342271
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42161074
89cell proliferation in forebrain (GO:0021846)2.42132453
90eosinophil migration (GO:0072677)2.41891713
91cytochrome complex assembly (GO:0017004)2.41285214
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38492976
93GPI anchor metabolic process (GO:0006505)2.35607298
94actin nucleation (GO:0045010)2.35516500
95positive regulation of cell fate commitment (GO:0010455)2.35501032
96aldehyde catabolic process (GO:0046185)2.35485777
97negative regulation of DNA-templated transcription, elongation (GO:0032785)2.35014367
98protein targeting (GO:0006605)2.34639795
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32990583
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31730820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21064808
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48260928
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.17641208
4VDR_22108803_ChIP-Seq_LS180_Human2.69235466
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32993916
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.22933183
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.21883358
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13508776
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05934749
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02073696
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00739007
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98034933
13ETS1_20019798_ChIP-Seq_JURKAT_Human1.97457982
14ZNF274_21170338_ChIP-Seq_K562_Hela1.95521268
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94438870
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87169475
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86024558
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84712302
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77359866
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71150627
21VDR_23849224_ChIP-Seq_CD4+_Human1.69772634
22NANOG_20526341_ChIP-Seq_ESCs_Human1.61777709
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59051763
24MYC_18940864_ChIP-ChIP_HL60_Human1.58408981
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55467924
26TAF2_19829295_ChIP-Seq_ESCs_Human1.55082927
27TP53_22573176_ChIP-Seq_HFKS_Human1.52409659
28IGF1R_20145208_ChIP-Seq_DFB_Human1.49190292
29ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40093335
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38863944
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38758356
32AR_20517297_ChIP-Seq_VCAP_Human1.37729742
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.36121657
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35933564
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.35874478
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34906603
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34747106
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34072015
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33682438
40NCOR_22424771_ChIP-Seq_293T_Human1.33237425
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.31145643
42ERA_21632823_ChIP-Seq_H3396_Human1.29942436
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29583222
44BCL6_27268052_Chip-Seq_Bcells_Human1.29543116
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29514525
46MYC_19829295_ChIP-Seq_ESCs_Human1.28600331
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26943246
48CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26123899
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25615499
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25514167
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25166929
52EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23534541
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22899738
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.22804232
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22804232
56ELK1_19687146_ChIP-ChIP_HELA_Human1.21715598
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21657806
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.20950865
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.18860666
60CTCF_20526341_ChIP-Seq_ESCs_Human1.17396159
61P53_21459846_ChIP-Seq_SAOS-2_Human1.16615200
62GATA3_26560356_Chip-Seq_TH2_Human1.15600961
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.15137346
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.15046477
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14045394
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12519866
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11568251
68FOXP3_21729870_ChIP-Seq_TREG_Human1.11535767
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09743561
70BCAT_22108803_ChIP-Seq_LS180_Human1.09557691
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08765714
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08397263
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08374948
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08355552
75SA1_27219007_Chip-Seq_Bcells_Human1.07716115
76EWS_26573619_Chip-Seq_HEK293_Human1.06297080
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.05028030
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04015466
79P300_27268052_Chip-Seq_Bcells_Human1.03631150
80NANOG_19829295_ChIP-Seq_ESCs_Human1.03451661
81SOX2_19829295_ChIP-Seq_ESCs_Human1.03451661
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02982318
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.02411072
84ERG_20517297_ChIP-Seq_VCAP_Human1.00844406
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00639384
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99443099
87MYC_18555785_ChIP-Seq_MESCs_Mouse0.97658275
88OCT4_20526341_ChIP-Seq_ESCs_Human0.97588243
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.96580524
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95840891
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95631033
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.95628088
93HTT_18923047_ChIP-ChIP_STHdh_Human0.95254303
94MYB_26560356_Chip-Seq_TH2_Human0.94771730
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.94412257
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92162066
97CBP_20019798_ChIP-Seq_JUKART_Human0.92162066
98RAC3_21632823_ChIP-Seq_H3396_Human0.91647790
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91048919
100RNF2_27304074_Chip-Seq_NSC_Mouse0.89478911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.21777152
2MP0005671_abnormal_response_to3.41884446
3MP0006292_abnormal_olfactory_placode3.27630155
4MP0003646_muscle_fatigue3.04400289
5MP0002638_abnormal_pupillary_reflex2.50593536
6MP0001873_stomach_inflammation2.48931535
7MP0008877_abnormal_DNA_methylation2.47356106
8MP0002837_dystrophic_cardiac_calcinosis2.26992804
9MP0005645_abnormal_hypothalamus_physiol2.21005225
10MP0002102_abnormal_ear_morphology2.11269642
11MP0001835_abnormal_antigen_presentation2.00536202
12MP0005377_hearing/vestibular/ear_phenot1.98728549
13MP0003878_abnormal_ear_physiology1.98728549
14MP0002653_abnormal_ependyma_morphology1.85095630
15MP0004147_increased_porphyrin_level1.84576136
16MP0008789_abnormal_olfactory_epithelium1.77889838
17MP0004885_abnormal_endolymph1.73300766
18MP0008872_abnormal_physiological_respon1.71846681
19MP0005360_urolithiasis1.69353309
20MP0006072_abnormal_retinal_apoptosis1.58033388
21MP0000372_irregular_coat_pigmentation1.57858453
22MP0001485_abnormal_pinna_reflex1.54210678
23MP0002876_abnormal_thyroid_physiology1.53332260
24MP0005551_abnormal_eye_electrophysiolog1.52796828
25MP0009333_abnormal_splenocyte_physiolog1.52455360
26MP0003011_delayed_dark_adaptation1.50990300
27MP0001986_abnormal_taste_sensitivity1.47991287
28MP0009785_altered_susceptibility_to1.46127993
29MP0002163_abnormal_gland_morphology1.45778464
30MP0000685_abnormal_immune_system1.41168033
31MP0010155_abnormal_intestine_physiology1.39201810
32MP0001800_abnormal_humoral_immune1.37284334
33MP0001790_abnormal_immune_system1.36410476
34MP0005387_immune_system_phenotype1.36410476
35MP0002166_altered_tumor_susceptibility1.32283031
36MP0004019_abnormal_vitamin_homeostasis1.31046827
37MP0002095_abnormal_skin_pigmentation1.30953467
38MP0008995_early_reproductive_senescence1.27227637
39MP0004142_abnormal_muscle_tone1.26317716
40MP0001968_abnormal_touch/_nociception1.26093332
41MP0005646_abnormal_pituitary_gland1.24778768
42MP0002148_abnormal_hypersensitivity_rea1.20939140
43MP0005075_abnormal_melanosome_morpholog1.20516683
44MP0003787_abnormal_imprinting1.16130644
45MP0000049_abnormal_middle_ear1.15262450
46MP0005394_taste/olfaction_phenotype1.13532478
47MP0005499_abnormal_olfactory_system1.13532478
48MP0003122_maternal_imprinting1.13444984
49MP0000678_abnormal_parathyroid_gland1.12881325
50MP0003763_abnormal_thymus_physiology1.12663870
51MP0003866_abnormal_defecation1.12163176
52MP0001905_abnormal_dopamine_level1.11647797
53MP0005000_abnormal_immune_tolerance1.10913763
54MP0002736_abnormal_nociception_after1.10721814
55MP0002006_tumorigenesis1.08747628
56MP0001764_abnormal_homeostasis1.07530916
57MP0005253_abnormal_eye_physiology1.06458466
58MP0008875_abnormal_xenobiotic_pharmacok1.06297993
59MP0001663_abnormal_digestive_system1.04583437
60MP0001293_anophthalmia1.04006996
61MP0002272_abnormal_nervous_system1.03580146
62MP0005174_abnormal_tail_pigmentation1.02696226
63MP0005025_abnormal_response_to1.00892228
64MP0006276_abnormal_autonomic_nervous1.00234280
65MP0003880_abnormal_central_pattern0.99652294
66MP0009764_decreased_sensitivity_to0.99474981
67MP0004145_abnormal_muscle_electrophysio0.98997196
68MP0004742_abnormal_vestibular_system0.98840233
69MP0001529_abnormal_vocalization0.98634077
70MP0002822_catalepsy0.98633860
71MP0002234_abnormal_pharynx_morphology0.97994016
72MP0002277_abnormal_respiratory_mucosa0.97780506
73MP0002938_white_spotting0.95765647
74MP0001919_abnormal_reproductive_system0.94280678
75MP0001188_hyperpigmentation0.93970350
76MP0005389_reproductive_system_phenotype0.93516806
77MP0000026_abnormal_inner_ear0.92671365
78MP0005195_abnormal_posterior_eye0.91772843
79MP0002723_abnormal_immune_serum0.91512441
80MP0004043_abnormal_pH_regulation0.91478347
81MP0002420_abnormal_adaptive_immunity0.91271001
82MP0000427_abnormal_hair_cycle0.90788875
83MP0002138_abnormal_hepatobiliary_system0.89494940
84MP0001819_abnormal_immune_cell0.87802773
85MP0003938_abnormal_ear_development0.87369547
86MP0002160_abnormal_reproductive_system0.81439294
87MP0001963_abnormal_hearing_physiology0.79421990
88MP0001970_abnormal_pain_threshold0.79291027
89MP0005085_abnormal_gallbladder_physiolo0.78412058
90MP0003567_abnormal_fetal_cardiomyocyte0.78059598
91MP0001845_abnormal_inflammatory_respons0.77709389
92MP0001666_abnormal_nutrient_absorption0.76695300
93MP0000631_abnormal_neuroendocrine_gland0.75921976
94MP0001664_abnormal_digestion0.74766595
95MP0008775_abnormal_heart_ventricle0.74252433
96MP0002452_abnormal_antigen_presenting0.68446150
97MP0001984_abnormal_olfaction0.67633396
98MP0002733_abnormal_thermal_nociception0.66618280
99MP0005381_digestive/alimentary_phenotyp0.65628631
100MP0003879_abnormal_hair_cell0.64884070

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.62808423
2Reticulocytopenia (HP:0001896)4.37336106
3Mitochondrial inheritance (HP:0001427)4.18803653
4Acute encephalopathy (HP:0006846)4.05452946
5Abnormal mitochondria in muscle tissue (HP:0008316)3.99435118
6Abnormality of cells of the erythroid lineage (HP:0012130)3.88655540
7Progressive macrocephaly (HP:0004481)3.65867475
8Increased CSF lactate (HP:0002490)3.59834489
9Macrocytic anemia (HP:0001972)3.54078559
10Increased hepatocellular lipid droplets (HP:0006565)3.47737850
11Lipid accumulation in hepatocytes (HP:0006561)3.29714991
12Cerebral edema (HP:0002181)3.11160912
13Elevated erythrocyte sedimentation rate (HP:0003565)3.06057774
14Abnormality of midbrain morphology (HP:0002418)3.04848660
15Molar tooth sign on MRI (HP:0002419)3.04848660
16Hepatocellular necrosis (HP:0001404)3.03735016
17IgG deficiency (HP:0004315)3.03632544
18Pancreatic fibrosis (HP:0100732)3.01755847
193-Methylglutaconic aciduria (HP:0003535)3.00674713
20Congenital stationary night blindness (HP:0007642)2.96216778
21Pancreatic cysts (HP:0001737)2.95606166
22Abnormal number of erythroid precursors (HP:0012131)2.89672976
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.85844264
24Stenosis of the external auditory canal (HP:0000402)2.84581264
25Increased intramyocellular lipid droplets (HP:0012240)2.81635426
26True hermaphroditism (HP:0010459)2.80929540
27Abnormal rod and cone electroretinograms (HP:0008323)2.79462440
28Renal Fanconi syndrome (HP:0001994)2.77323621
29Asplenia (HP:0001746)2.74474833
30Hepatic necrosis (HP:0002605)2.71359556
31Optic disc pallor (HP:0000543)2.69737004
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.69629283
33Increased IgM level (HP:0003496)2.68915607
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65847490
35Absent thumb (HP:0009777)2.61311859
36Aplastic anemia (HP:0001915)2.51558031
37Exertional dyspnea (HP:0002875)2.51421992
38Pallor (HP:0000980)2.45101835
39Increased muscle lipid content (HP:0009058)2.44422972
40Hyperglycinemia (HP:0002154)2.42998438
41Pendular nystagmus (HP:0012043)2.36728827
42Septo-optic dysplasia (HP:0100842)2.35749033
43Absent/shortened dynein arms (HP:0200106)2.34426945
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.34426945
45Abnormality of B cell number (HP:0010975)2.33567238
46Medial flaring of the eyebrow (HP:0010747)2.30690816
47Severe combined immunodeficiency (HP:0004430)2.30163080
48Stomatitis (HP:0010280)2.28051451
49Abnormality of urine glucose concentration (HP:0011016)2.26879096
50Glycosuria (HP:0003076)2.26879096
51Abnormality of DNA repair (HP:0003254)2.24377071
52Abolished electroretinogram (ERG) (HP:0000550)2.21121179
53Hyperphosphaturia (HP:0003109)2.20400490
54Lethargy (HP:0001254)2.19159773
55Congenital, generalized hypertrichosis (HP:0004540)2.18183218
56Hypoproteinemia (HP:0003075)2.15978917
57Lactic acidosis (HP:0003128)2.15889520
58Increased serum lactate (HP:0002151)2.15403775
59B lymphocytopenia (HP:0010976)2.10984938
60Decreased central vision (HP:0007663)2.10684006
61Abnormal respiratory epithelium morphology (HP:0012253)2.09470437
62Abnormal respiratory motile cilium morphology (HP:0005938)2.09470437
63Decreased circulating renin level (HP:0003351)2.07402148
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06965413
65Hypoplasia of the radius (HP:0002984)2.03741405
66Hypoplasia of the ulna (HP:0003022)2.02504603
67Cystic liver disease (HP:0006706)1.98584114
68Nephronophthisis (HP:0000090)1.98037339
69Forearm undergrowth (HP:0009821)1.96508705
70Exercise intolerance (HP:0003546)1.94316237
71Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94029991
72Colon cancer (HP:0003003)1.91276104
73Abnormality of T cells (HP:0002843)1.90685434
74Abnormal ciliary motility (HP:0012262)1.90134409
75Thyroiditis (HP:0100646)1.89417125
76Respiratory failure (HP:0002878)1.89146641
77Sclerocornea (HP:0000647)1.88987329
78Abnormality of renal resorption (HP:0011038)1.88879489
79Leukodystrophy (HP:0002415)1.84628590
80Autoimmune hemolytic anemia (HP:0001890)1.84091454
81Parakeratosis (HP:0001036)1.84087960
82Aplasia/Hypoplasia of the ulna (HP:0006495)1.81680703
83Supernumerary spleens (HP:0009799)1.77958391
84Abnormal albumin level (HP:0012116)1.76926300
85Hypoalbuminemia (HP:0003073)1.76926300
86Abnormality of serine family amino acid metabolism (HP:0010894)1.76347022
87Abnormality of glycine metabolism (HP:0010895)1.76347022
88Pancytopenia (HP:0001876)1.74850124
89Anomalous pulmonary venous return (HP:0010772)1.74185800
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73423426
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.73398080
92Neutropenia (HP:0001875)1.72550471
93Increased corneal curvature (HP:0100692)1.72125088
94Keratoconus (HP:0000563)1.72125088
95T lymphocytopenia (HP:0005403)1.71754078
96Male pseudohermaphroditism (HP:0000037)1.71488000
97Type II lissencephaly (HP:0007260)1.70543144
98Abnormality of T cell number (HP:0011839)1.70020216
99Severe visual impairment (HP:0001141)1.69660018
100Depressed nasal ridge (HP:0000457)1.69077846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.15091774
2MAP4K23.79363017
3CDK193.77432978
4KDR3.38099019
5ADRBK22.67478966
6WNK42.42653612
7BCKDK2.40270907
8STK162.38538581
9VRK22.24687566
10GRK12.23650047
11TESK22.14822003
12MAP4K12.04899233
13MAP3K121.95473889
14TAOK31.91767304
15NLK1.68913767
16TLK11.59985636
17TIE11.56619996
18MUSK1.56062453
19ZAK1.49653895
20MAP3K111.49531015
21DYRK21.42177399
22PINK11.40411882
23CAMKK21.36499955
24PASK1.34215773
25CDK81.30480892
26GRK61.29122631
27ITK1.26957789
28WNK31.21276519
29TEC1.20508440
30INSRR1.20056974
31LIMK11.17734639
32FRK1.16923797
33NUAK11.15997832
34IKBKE1.13345138
35MYLK1.13004004
36VRK11.12686109
37PIK3CA1.12527160
38BTK1.10210175
39STK391.08982310
40LRRK21.06475901
41PRKCQ1.01370211
42MAPK130.92651490
43MAP3K100.92485813
44SYK0.91604526
45DAPK30.89213892
46EPHB20.88681745
47ADRBK10.87674562
48CAMK10.86675785
49LYN0.85109217
50NEK10.84249828
51TYRO30.80932028
52OBSCN0.80551288
53IKBKB0.79495864
54CAMKK10.78833669
55LCK0.76505590
56GRK70.75973141
57WNK10.75732920
58OXSR10.74992861
59FES0.73956831
60CSK0.73209243
61KIT0.71106802
62EPHA40.70848678
63RPS6KA60.68584603
64CDK40.67896122
65ACVR1B0.66403411
66PIM10.65618500
67PRKACA0.65166424
68ILK0.59679406
69NTRK20.57811142
70NME10.57714715
71PRKCA0.54698538
72PRKCG0.52563221
73RPS6KA50.51908743
74AURKB0.51795351
75RPS6KL10.49080122
76RPS6KC10.49080122
77CSNK2A20.48108762
78DYRK1B0.47954344
79MAP2K70.45730566
80DAPK10.45538767
81TESK10.44761791
82BMPR1B0.42233147
83CSNK1G10.42082178
84PRKCE0.41822764
85CAMK2A0.41359019
86CAMK40.40729724
87MAPK70.40721388
88CSNK2A10.39766813
89PRKACG0.38758261
90STK110.38730502
91IGF1R0.38591367
92MAPK150.36500679
93MAP2K20.36468082
94TNK20.35043028
95PRKCD0.34998284
96GRK50.34892885
97PKN10.34865510
98PAK30.34652385
99CSNK1A10.34219683
100AURKA0.33493258

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.78095175
2Oxidative phosphorylation_Homo sapiens_hsa001903.95023575
3Parkinsons disease_Homo sapiens_hsa050123.22771249
4Primary immunodeficiency_Homo sapiens_hsa053402.75628914
5Asthma_Homo sapiens_hsa053102.66734461
6Proteasome_Homo sapiens_hsa030502.61256559
7Allograft rejection_Homo sapiens_hsa053302.43321212
8Autoimmune thyroid disease_Homo sapiens_hsa053202.41876642
9Cardiac muscle contraction_Homo sapiens_hsa042602.38045002
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.32766348
11Linoleic acid metabolism_Homo sapiens_hsa005912.22203357
12Alzheimers disease_Homo sapiens_hsa050102.19910418
13Huntingtons disease_Homo sapiens_hsa050162.18662384
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07204537
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01145414
16Graft-versus-host disease_Homo sapiens_hsa053321.88008974
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83032028
18RNA polymerase_Homo sapiens_hsa030201.79381403
19Protein export_Homo sapiens_hsa030601.77999069
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72492167
21Fat digestion and absorption_Homo sapiens_hsa049751.70084887
22Phototransduction_Homo sapiens_hsa047441.55591487
23Type I diabetes mellitus_Homo sapiens_hsa049401.55142582
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38870343
25Arachidonic acid metabolism_Homo sapiens_hsa005901.32109502
26Antigen processing and presentation_Homo sapiens_hsa046121.29865336
27Hematopoietic cell lineage_Homo sapiens_hsa046401.25877795
28Retinol metabolism_Homo sapiens_hsa008301.25409095
29RNA degradation_Homo sapiens_hsa030181.21538251
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12881855
31Homologous recombination_Homo sapiens_hsa034401.11452065
32Ether lipid metabolism_Homo sapiens_hsa005651.09224074
33Caffeine metabolism_Homo sapiens_hsa002321.07159357
34Chemical carcinogenesis_Homo sapiens_hsa052041.04218154
35Sulfur metabolism_Homo sapiens_hsa009201.00306037
36Rheumatoid arthritis_Homo sapiens_hsa053230.99719628
37Basal transcription factors_Homo sapiens_hsa030220.98936330
38Butanoate metabolism_Homo sapiens_hsa006500.95206997
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94967432
40Pyrimidine metabolism_Homo sapiens_hsa002400.94430063
41Sulfur relay system_Homo sapiens_hsa041220.93911004
42Nitrogen metabolism_Homo sapiens_hsa009100.93494722
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.91586476
44Peroxisome_Homo sapiens_hsa041460.90741639
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89216497
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87897205
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.84470612
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83570317
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76992864
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76928704
51Viral myocarditis_Homo sapiens_hsa054160.76643188
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69478885
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67706160
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67444714
55Mineral absorption_Homo sapiens_hsa049780.67031269
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66745845
57Nucleotide excision repair_Homo sapiens_hsa034200.66387277
58T cell receptor signaling pathway_Homo sapiens_hsa046600.66331710
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66251231
60Olfactory transduction_Homo sapiens_hsa047400.65791558
61Regulation of autophagy_Homo sapiens_hsa041400.62852434
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61517437
63Purine metabolism_Homo sapiens_hsa002300.59858906
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59233351
65Metabolic pathways_Homo sapiens_hsa011000.58737577
66Vitamin digestion and absorption_Homo sapiens_hsa049770.58016954
67Nicotine addiction_Homo sapiens_hsa050330.57498532
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55431978
69Systemic lupus erythematosus_Homo sapiens_hsa053220.54370402
70Tryptophan metabolism_Homo sapiens_hsa003800.52215022
71Morphine addiction_Homo sapiens_hsa050320.51615017
72Staphylococcus aureus infection_Homo sapiens_hsa051500.51452420
73Propanoate metabolism_Homo sapiens_hsa006400.50248050
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48575601
75Fanconi anemia pathway_Homo sapiens_hsa034600.47851384
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.47064556
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45514182
78Glutathione metabolism_Homo sapiens_hsa004800.44895555
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43406707
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.42268787
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.41411472
82Glycerolipid metabolism_Homo sapiens_hsa005610.39056044
83Taste transduction_Homo sapiens_hsa047420.38402836
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37302178
85Hedgehog signaling pathway_Homo sapiens_hsa043400.33887187
86One carbon pool by folate_Homo sapiens_hsa006700.33795571
87Ovarian steroidogenesis_Homo sapiens_hsa049130.32926994
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.32885149
89Collecting duct acid secretion_Homo sapiens_hsa049660.32788453
90Malaria_Homo sapiens_hsa051440.31048925
91RNA transport_Homo sapiens_hsa030130.27576771
92Mismatch repair_Homo sapiens_hsa034300.27049561
93Fatty acid degradation_Homo sapiens_hsa000710.26631743
94Starch and sucrose metabolism_Homo sapiens_hsa005000.24744826
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22992198
96Basal cell carcinoma_Homo sapiens_hsa052170.21652799
97Insulin secretion_Homo sapiens_hsa049110.21593651
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.20066855
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19328108
100GABAergic synapse_Homo sapiens_hsa047270.17353875

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