ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.46802031
2	viral transcription (GO:0019083)	7.29513667
3	translational termination (GO:0006415)	6.94634953
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.03793289
5	translational elongation (GO:0006414)	6.01352682
6	protein targeting to ER (GO:0045047)	5.94372343
7	cotranslational protein targeting to membrane (GO:0006613)	5.92800942
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.71266897
9	protein localization to endoplasmic reticulum (GO:0070972)	5.65864490
10	DNA deamination (GO:0045006)	5.39062507
11	viral life cycle (GO:0019058)	5.31116997
12	cellular protein complex disassembly (GO:0043624)	5.27720448
13	cytidine deamination (GO:0009972)	5.22381017
14	cytidine metabolic process (GO:0046087)	5.22381017
15	cytidine catabolic process (GO:0006216)	5.22381017
16	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.10018180
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.06584015
18	ATP synthesis coupled proton transport (GO:0015986)	5.00444123
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.00444123
20	ribosomal small subunit biogenesis (GO:0042274)	4.99944517
21	maturation of SSU-rRNA (GO:0030490)	4.81557191
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68289073
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.64506468
24	translational initiation (GO:0006413)	4.48203697
25	protein neddylation (GO:0045116)	4.38999640
26	protein complex disassembly (GO:0043241)	4.28906907
27	macromolecular complex disassembly (GO:0032984)	4.01862880
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.00565765
29	protein targeting to membrane (GO:0006612)	3.97779669
30	respiratory electron transport chain (GO:0022904)	3.86013740
31	ribosomal large subunit biogenesis (GO:0042273)	3.83971258
32	electron transport chain (GO:0022900)	3.82613152
33	translation (GO:0006412)	3.81175197
34	positive regulation of respiratory burst (GO:0060267)	3.69510590
35	behavioral response to nicotine (GO:0035095)	3.66707002
36	sequestering of actin monomers (GO:0042989)	3.53694723
37	protein complex biogenesis (GO:0070271)	3.51590423
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.49307076
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37688904
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35520923
41	GTP biosynthetic process (GO:0006183)	3.34395040
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.33021266
43	mRNA catabolic process (GO:0006402)	3.28294370
44	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.25603051
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22793705
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22793705
47	NADH dehydrogenase complex assembly (GO:0010257)	3.22793705
48	regulation of regulatory T cell differentiation (GO:0045589)	3.17611492
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12989086
50	platelet dense granule organization (GO:0060155)	3.08696573
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.06047229
52	axoneme assembly (GO:0035082)	3.02783394
53	RNA catabolic process (GO:0006401)	3.01958897
54	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.00668983
55	DNA demethylation (GO:0080111)	3.00310812
56	response to pheromone (GO:0019236)	2.97688348
57	ATP biosynthetic process (GO:0006754)	2.97095289
58	hydrogen ion transmembrane transport (GO:1902600)	2.95577918
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.92797982
60	pyrimidine nucleotide catabolic process (GO:0006244)	2.89756184
61	regulation of respiratory burst (GO:0060263)	2.82548895
62	UTP biosynthetic process (GO:0006228)	2.81988088
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77826871
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77826871
65	proton transport (GO:0015992)	2.75997277
66	DNA dealkylation (GO:0035510)	2.73858758
67	cellular component biogenesis (GO:0044085)	2.73098926
68	establishment of protein localization to membrane (GO:0090150)	2.71876094
69	pyrimidine nucleoside catabolic process (GO:0046135)	2.68656095
70	hydrogen transport (GO:0006818)	2.67443130
71	antibacterial humoral response (GO:0019731)	2.67118607
72	negative regulation of mast cell activation (GO:0033004)	2.66944595
73	eosinophil chemotaxis (GO:0048245)	2.65890885
74	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.65121826
75	disruption of cells of other organism (GO:0044364)	2.64574366
76	killing of cells of other organism (GO:0031640)	2.64574366
77	regulation of isotype switching to IgG isotypes (GO:0048302)	2.61740449
78	ribonucleoprotein complex biogenesis (GO:0022613)	2.61689182
79	neuron fate determination (GO:0048664)	2.56860853
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.56590313
81	UTP metabolic process (GO:0046051)	2.53286819
82	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.51948784
83	somite development (GO:0061053)	2.49330577
84	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.46163791
85	positive regulation of defense response to virus by host (GO:0002230)	2.46058873
86	antimicrobial humoral response (GO:0019730)	2.45478315
87	mannosylation (GO:0097502)	2.45342271
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.42161074
89	cell proliferation in forebrain (GO:0021846)	2.42132453
90	eosinophil migration (GO:0072677)	2.41891713
91	cytochrome complex assembly (GO:0017004)	2.41285214
92	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.38492976
93	GPI anchor metabolic process (GO:0006505)	2.35607298
94	actin nucleation (GO:0045010)	2.35516500
95	positive regulation of cell fate commitment (GO:0010455)	2.35501032
96	aldehyde catabolic process (GO:0046185)	2.35485777
97	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.35014367
98	protein targeting (GO:0006605)	2.34639795
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.32990583
100	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.31730820

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.21064808
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.48260928
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17641208
4	VDR_22108803_ChIP-Seq_LS180_Human	2.69235466
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32993916
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.22933183
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.21883358
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13508776
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05934749
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.02073696
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00739007
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.98034933
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97457982
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.95521268
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94438870
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.87169475
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86024558
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.84712302
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.77359866
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.71150627
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.69772634
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.61777709
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59051763
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.58408981
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.55467924
26	TAF2_19829295_ChIP-Seq_ESCs_Human	1.55082927
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.52409659
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49190292
29	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40093335
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38863944
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38758356
32	AR_20517297_ChIP-Seq_VCAP_Human	1.37729742
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36121657
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35933564
35	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35874478
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.34906603
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34747106
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34072015
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.33682438
40	NCOR_22424771_ChIP-Seq_293T_Human	1.33237425
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.31145643
42	ERA_21632823_ChIP-Seq_H3396_Human	1.29942436
43	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.29583222
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.29543116
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29514525
46	MYC_19829295_ChIP-Seq_ESCs_Human	1.28600331
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26943246
48	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26123899
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25615499
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25514167
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25166929
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.23534541
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22899738
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22804232
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22804232
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21715598
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21657806
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.20950865
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18860666
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17396159
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.16615200
62	GATA3_26560356_Chip-Seq_TH2_Human	1.15600961
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15137346
64	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.15046477
65	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14045394
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.12519866
67	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.11568251
68	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11535767
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.09743561
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.09557691
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08765714
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08397263
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08374948
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08355552
75	SA1_27219007_Chip-Seq_Bcells_Human	1.07716115
76	EWS_26573619_Chip-Seq_HEK293_Human	1.06297080
77	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.05028030
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04015466
79	P300_27268052_Chip-Seq_Bcells_Human	1.03631150
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03451661
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03451661
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02982318
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02411072
84	ERG_20517297_ChIP-Seq_VCAP_Human	1.00844406
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.00639384
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99443099
87	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.97658275
88	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97588243
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96580524
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95840891
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.95631033
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95628088
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95254303
94	MYB_26560356_Chip-Seq_TH2_Human	0.94771730
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94412257
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.92162066
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92162066
98	RAC3_21632823_ChIP-Seq_H3396_Human	0.91647790
99	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.91048919
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89478911

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.21777152
2	MP0005671_abnormal_response_to	3.41884446
3	MP0006292_abnormal_olfactory_placode	3.27630155
4	MP0003646_muscle_fatigue	3.04400289
5	MP0002638_abnormal_pupillary_reflex	2.50593536
6	MP0001873_stomach_inflammation	2.48931535
7	MP0008877_abnormal_DNA_methylation	2.47356106
8	MP0002837_dystrophic_cardiac_calcinosis	2.26992804
9	MP0005645_abnormal_hypothalamus_physiol	2.21005225
10	MP0002102_abnormal_ear_morphology	2.11269642
11	MP0001835_abnormal_antigen_presentation	2.00536202
12	MP0005377_hearing/vestibular/ear_phenot	1.98728549
13	MP0003878_abnormal_ear_physiology	1.98728549
14	MP0002653_abnormal_ependyma_morphology	1.85095630
15	MP0004147_increased_porphyrin_level	1.84576136
16	MP0008789_abnormal_olfactory_epithelium	1.77889838
17	MP0004885_abnormal_endolymph	1.73300766
18	MP0008872_abnormal_physiological_respon	1.71846681
19	MP0005360_urolithiasis	1.69353309
20	MP0006072_abnormal_retinal_apoptosis	1.58033388
21	MP0000372_irregular_coat_pigmentation	1.57858453
22	MP0001485_abnormal_pinna_reflex	1.54210678
23	MP0002876_abnormal_thyroid_physiology	1.53332260
24	MP0005551_abnormal_eye_electrophysiolog	1.52796828
25	MP0009333_abnormal_splenocyte_physiolog	1.52455360
26	MP0003011_delayed_dark_adaptation	1.50990300
27	MP0001986_abnormal_taste_sensitivity	1.47991287
28	MP0009785_altered_susceptibility_to	1.46127993
29	MP0002163_abnormal_gland_morphology	1.45778464
30	MP0000685_abnormal_immune_system	1.41168033
31	MP0010155_abnormal_intestine_physiology	1.39201810
32	MP0001800_abnormal_humoral_immune	1.37284334
33	MP0001790_abnormal_immune_system	1.36410476
34	MP0005387_immune_system_phenotype	1.36410476
35	MP0002166_altered_tumor_susceptibility	1.32283031
36	MP0004019_abnormal_vitamin_homeostasis	1.31046827
37	MP0002095_abnormal_skin_pigmentation	1.30953467
38	MP0008995_early_reproductive_senescence	1.27227637
39	MP0004142_abnormal_muscle_tone	1.26317716
40	MP0001968_abnormal_touch/_nociception	1.26093332
41	MP0005646_abnormal_pituitary_gland	1.24778768
42	MP0002148_abnormal_hypersensitivity_rea	1.20939140
43	MP0005075_abnormal_melanosome_morpholog	1.20516683
44	MP0003787_abnormal_imprinting	1.16130644
45	MP0000049_abnormal_middle_ear	1.15262450
46	MP0005394_taste/olfaction_phenotype	1.13532478
47	MP0005499_abnormal_olfactory_system	1.13532478
48	MP0003122_maternal_imprinting	1.13444984
49	MP0000678_abnormal_parathyroid_gland	1.12881325
50	MP0003763_abnormal_thymus_physiology	1.12663870
51	MP0003866_abnormal_defecation	1.12163176
52	MP0001905_abnormal_dopamine_level	1.11647797
53	MP0005000_abnormal_immune_tolerance	1.10913763
54	MP0002736_abnormal_nociception_after	1.10721814
55	MP0002006_tumorigenesis	1.08747628
56	MP0001764_abnormal_homeostasis	1.07530916
57	MP0005253_abnormal_eye_physiology	1.06458466
58	MP0008875_abnormal_xenobiotic_pharmacok	1.06297993
59	MP0001663_abnormal_digestive_system	1.04583437
60	MP0001293_anophthalmia	1.04006996
61	MP0002272_abnormal_nervous_system	1.03580146
62	MP0005174_abnormal_tail_pigmentation	1.02696226
63	MP0005025_abnormal_response_to	1.00892228
64	MP0006276_abnormal_autonomic_nervous	1.00234280
65	MP0003880_abnormal_central_pattern	0.99652294
66	MP0009764_decreased_sensitivity_to	0.99474981
67	MP0004145_abnormal_muscle_electrophysio	0.98997196
68	MP0004742_abnormal_vestibular_system	0.98840233
69	MP0001529_abnormal_vocalization	0.98634077
70	MP0002822_catalepsy	0.98633860
71	MP0002234_abnormal_pharynx_morphology	0.97994016
72	MP0002277_abnormal_respiratory_mucosa	0.97780506
73	MP0002938_white_spotting	0.95765647
74	MP0001919_abnormal_reproductive_system	0.94280678
75	MP0001188_hyperpigmentation	0.93970350
76	MP0005389_reproductive_system_phenotype	0.93516806
77	MP0000026_abnormal_inner_ear	0.92671365
78	MP0005195_abnormal_posterior_eye	0.91772843
79	MP0002723_abnormal_immune_serum	0.91512441
80	MP0004043_abnormal_pH_regulation	0.91478347
81	MP0002420_abnormal_adaptive_immunity	0.91271001
82	MP0000427_abnormal_hair_cycle	0.90788875
83	MP0002138_abnormal_hepatobiliary_system	0.89494940
84	MP0001819_abnormal_immune_cell	0.87802773
85	MP0003938_abnormal_ear_development	0.87369547
86	MP0002160_abnormal_reproductive_system	0.81439294
87	MP0001963_abnormal_hearing_physiology	0.79421990
88	MP0001970_abnormal_pain_threshold	0.79291027
89	MP0005085_abnormal_gallbladder_physiolo	0.78412058
90	MP0003567_abnormal_fetal_cardiomyocyte	0.78059598
91	MP0001845_abnormal_inflammatory_respons	0.77709389
92	MP0001666_abnormal_nutrient_absorption	0.76695300
93	MP0000631_abnormal_neuroendocrine_gland	0.75921976
94	MP0001664_abnormal_digestion	0.74766595
95	MP0008775_abnormal_heart_ventricle	0.74252433
96	MP0002452_abnormal_antigen_presenting	0.68446150
97	MP0001984_abnormal_olfaction	0.67633396
98	MP0002733_abnormal_thermal_nociception	0.66618280
99	MP0005381_digestive/alimentary_phenotyp	0.65628631
100	MP0003879_abnormal_hair_cell	0.64884070

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.62808423
2	Reticulocytopenia (HP:0001896)	4.37336106
3	Mitochondrial inheritance (HP:0001427)	4.18803653
4	Acute encephalopathy (HP:0006846)	4.05452946
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.99435118
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.88655540
7	Progressive macrocephaly (HP:0004481)	3.65867475
8	Increased CSF lactate (HP:0002490)	3.59834489
9	Macrocytic anemia (HP:0001972)	3.54078559
10	Increased hepatocellular lipid droplets (HP:0006565)	3.47737850
11	Lipid accumulation in hepatocytes (HP:0006561)	3.29714991
12	Cerebral edema (HP:0002181)	3.11160912
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.06057774
14	Abnormality of midbrain morphology (HP:0002418)	3.04848660
15	Molar tooth sign on MRI (HP:0002419)	3.04848660
16	Hepatocellular necrosis (HP:0001404)	3.03735016
17	IgG deficiency (HP:0004315)	3.03632544
18	Pancreatic fibrosis (HP:0100732)	3.01755847
19	3-Methylglutaconic aciduria (HP:0003535)	3.00674713
20	Congenital stationary night blindness (HP:0007642)	2.96216778
21	Pancreatic cysts (HP:0001737)	2.95606166
22	Abnormal number of erythroid precursors (HP:0012131)	2.89672976
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85844264
24	Stenosis of the external auditory canal (HP:0000402)	2.84581264
25	Increased intramyocellular lipid droplets (HP:0012240)	2.81635426
26	True hermaphroditism (HP:0010459)	2.80929540
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.79462440
28	Renal Fanconi syndrome (HP:0001994)	2.77323621
29	Asplenia (HP:0001746)	2.74474833
30	Hepatic necrosis (HP:0002605)	2.71359556
31	Optic disc pallor (HP:0000543)	2.69737004
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.69629283
33	Increased IgM level (HP:0003496)	2.68915607
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65847490
35	Absent thumb (HP:0009777)	2.61311859
36	Aplastic anemia (HP:0001915)	2.51558031
37	Exertional dyspnea (HP:0002875)	2.51421992
38	Pallor (HP:0000980)	2.45101835
39	Increased muscle lipid content (HP:0009058)	2.44422972
40	Hyperglycinemia (HP:0002154)	2.42998438
41	Pendular nystagmus (HP:0012043)	2.36728827
42	Septo-optic dysplasia (HP:0100842)	2.35749033
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.34426945
44	Absent/shortened dynein arms (HP:0200106)	2.34426945
45	Abnormality of B cell number (HP:0010975)	2.33567238
46	Medial flaring of the eyebrow (HP:0010747)	2.30690816
47	Severe combined immunodeficiency (HP:0004430)	2.30163080
48	Stomatitis (HP:0010280)	2.28051451
49	Abnormality of urine glucose concentration (HP:0011016)	2.26879096
50	Glycosuria (HP:0003076)	2.26879096
51	Abnormality of DNA repair (HP:0003254)	2.24377071
52	Abolished electroretinogram (ERG) (HP:0000550)	2.21121179
53	Hyperphosphaturia (HP:0003109)	2.20400490
54	Lethargy (HP:0001254)	2.19159773
55	Congenital, generalized hypertrichosis (HP:0004540)	2.18183218
56	Hypoproteinemia (HP:0003075)	2.15978917
57	Lactic acidosis (HP:0003128)	2.15889520
58	Increased serum lactate (HP:0002151)	2.15403775
59	B lymphocytopenia (HP:0010976)	2.10984938
60	Decreased central vision (HP:0007663)	2.10684006
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.09470437
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09470437
63	Decreased circulating renin level (HP:0003351)	2.07402148
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.06965413
65	Hypoplasia of the radius (HP:0002984)	2.03741405
66	Hypoplasia of the ulna (HP:0003022)	2.02504603
67	Cystic liver disease (HP:0006706)	1.98584114
68	Nephronophthisis (HP:0000090)	1.98037339
69	Forearm undergrowth (HP:0009821)	1.96508705
70	Exercise intolerance (HP:0003546)	1.94316237
71	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94029991
72	Colon cancer (HP:0003003)	1.91276104
73	Abnormality of T cells (HP:0002843)	1.90685434
74	Abnormal ciliary motility (HP:0012262)	1.90134409
75	Thyroiditis (HP:0100646)	1.89417125
76	Respiratory failure (HP:0002878)	1.89146641
77	Sclerocornea (HP:0000647)	1.88987329
78	Abnormality of renal resorption (HP:0011038)	1.88879489
79	Leukodystrophy (HP:0002415)	1.84628590
80	Autoimmune hemolytic anemia (HP:0001890)	1.84091454
81	Parakeratosis (HP:0001036)	1.84087960
82	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.81680703
83	Supernumerary spleens (HP:0009799)	1.77958391
84	Hypoalbuminemia (HP:0003073)	1.76926300
85	Abnormal albumin level (HP:0012116)	1.76926300
86	Abnormality of glycine metabolism (HP:0010895)	1.76347022
87	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76347022
88	Pancytopenia (HP:0001876)	1.74850124
89	Anomalous pulmonary venous return (HP:0010772)	1.74185800
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73423426
91	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.73398080
92	Neutropenia (HP:0001875)	1.72550471
93	Increased corneal curvature (HP:0100692)	1.72125088
94	Keratoconus (HP:0000563)	1.72125088
95	T lymphocytopenia (HP:0005403)	1.71754078
96	Male pseudohermaphroditism (HP:0000037)	1.71488000
97	Type II lissencephaly (HP:0007260)	1.70543144
98	Abnormality of T cell number (HP:0011839)	1.70020216
99	Severe visual impairment (HP:0001141)	1.69660018
100	Depressed nasal ridge (HP:0000457)	1.69077846

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.15091774
2	MAP4K2	3.79363017
3	CDK19	3.77432978
4	KDR	3.38099019
5	ADRBK2	2.67478966
6	WNK4	2.42653612
7	BCKDK	2.40270907
8	STK16	2.38538581
9	VRK2	2.24687566
10	GRK1	2.23650047
11	TESK2	2.14822003
12	MAP4K1	2.04899233
13	MAP3K12	1.95473889
14	TAOK3	1.91767304
15	NLK	1.68913767
16	TLK1	1.59985636
17	TIE1	1.56619996
18	MUSK	1.56062453
19	ZAK	1.49653895
20	MAP3K11	1.49531015
21	DYRK2	1.42177399
22	PINK1	1.40411882
23	CAMKK2	1.36499955
24	PASK	1.34215773
25	CDK8	1.30480892
26	GRK6	1.29122631
27	ITK	1.26957789
28	WNK3	1.21276519
29	TEC	1.20508440
30	INSRR	1.20056974
31	LIMK1	1.17734639
32	FRK	1.16923797
33	NUAK1	1.15997832
34	IKBKE	1.13345138
35	MYLK	1.13004004
36	VRK1	1.12686109
37	PIK3CA	1.12527160
38	BTK	1.10210175
39	STK39	1.08982310
40	LRRK2	1.06475901
41	PRKCQ	1.01370211
42	MAPK13	0.92651490
43	MAP3K10	0.92485813
44	SYK	0.91604526
45	DAPK3	0.89213892
46	EPHB2	0.88681745
47	ADRBK1	0.87674562
48	CAMK1	0.86675785
49	LYN	0.85109217
50	NEK1	0.84249828
51	TYRO3	0.80932028
52	OBSCN	0.80551288
53	IKBKB	0.79495864
54	CAMKK1	0.78833669
55	LCK	0.76505590
56	GRK7	0.75973141
57	WNK1	0.75732920
58	OXSR1	0.74992861
59	FES	0.73956831
60	CSK	0.73209243
61	KIT	0.71106802
62	EPHA4	0.70848678
63	RPS6KA6	0.68584603
64	CDK4	0.67896122
65	ACVR1B	0.66403411
66	PIM1	0.65618500
67	PRKACA	0.65166424
68	ILK	0.59679406
69	NTRK2	0.57811142
70	NME1	0.57714715
71	PRKCA	0.54698538
72	PRKCG	0.52563221
73	RPS6KA5	0.51908743
74	AURKB	0.51795351
75	RPS6KC1	0.49080122
76	RPS6KL1	0.49080122
77	CSNK2A2	0.48108762
78	DYRK1B	0.47954344
79	MAP2K7	0.45730566
80	DAPK1	0.45538767
81	TESK1	0.44761791
82	BMPR1B	0.42233147
83	CSNK1G1	0.42082178
84	PRKCE	0.41822764
85	CAMK2A	0.41359019
86	CAMK4	0.40729724
87	MAPK7	0.40721388
88	CSNK2A1	0.39766813
89	PRKACG	0.38758261
90	STK11	0.38730502
91	IGF1R	0.38591367
92	MAPK15	0.36500679
93	MAP2K2	0.36468082
94	TNK2	0.35043028
95	PRKCD	0.34998284
96	GRK5	0.34892885
97	PKN1	0.34865510
98	PAK3	0.34652385
99	CSNK1A1	0.34219683
100	AURKA	0.33493258

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.78095175
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.95023575
3	Parkinsons disease_Homo sapiens_hsa05012	3.22771249
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.75628914
5	Asthma_Homo sapiens_hsa05310	2.66734461
6	Proteasome_Homo sapiens_hsa03050	2.61256559
7	Allograft rejection_Homo sapiens_hsa05330	2.43321212
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.41876642
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.38045002
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.32766348
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22203357
12	Alzheimers disease_Homo sapiens_hsa05010	2.19910418
13	Huntingtons disease_Homo sapiens_hsa05016	2.18662384
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.07204537
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.01145414
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.88008974
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83032028
18	RNA polymerase_Homo sapiens_hsa03020	1.79381403
19	Protein export_Homo sapiens_hsa03060	1.77999069
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72492167
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.70084887
22	Phototransduction_Homo sapiens_hsa04744	1.55591487
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.55142582
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.38870343
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32109502
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.29865336
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.25877795
28	Retinol metabolism_Homo sapiens_hsa00830	1.25409095
29	RNA degradation_Homo sapiens_hsa03018	1.21538251
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.12881855
31	Homologous recombination_Homo sapiens_hsa03440	1.11452065
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.09224074
33	Caffeine metabolism_Homo sapiens_hsa00232	1.07159357
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04218154
35	Sulfur metabolism_Homo sapiens_hsa00920	1.00306037
36	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99719628
37	Basal transcription factors_Homo sapiens_hsa03022	0.98936330
38	Butanoate metabolism_Homo sapiens_hsa00650	0.95206997
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94967432
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94430063
41	Sulfur relay system_Homo sapiens_hsa04122	0.93911004
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.93494722
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91586476
44	Peroxisome_Homo sapiens_hsa04146	0.90741639
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89216497
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.87897205
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84470612
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83570317
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76992864
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76928704
51	Viral myocarditis_Homo sapiens_hsa05416	0.76643188
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69478885
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.67706160
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67444714
55	Mineral absorption_Homo sapiens_hsa04978	0.67031269
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66745845
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.66387277
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66331710
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66251231
60	Olfactory transduction_Homo sapiens_hsa04740	0.65791558
61	Regulation of autophagy_Homo sapiens_hsa04140	0.62852434
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61517437
63	Purine metabolism_Homo sapiens_hsa00230	0.59858906
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59233351
65	Metabolic pathways_Homo sapiens_hsa01100	0.58737577
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58016954
67	Nicotine addiction_Homo sapiens_hsa05033	0.57498532
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55431978
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54370402
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.52215022
71	Morphine addiction_Homo sapiens_hsa05032	0.51615017
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51452420
73	Propanoate metabolism_Homo sapiens_hsa00640	0.50248050
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48575601
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.47851384
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47064556
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45514182
78	Glutathione metabolism_Homo sapiens_hsa00480	0.44895555
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43406707
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42268787
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41411472
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39056044
83	Taste transduction_Homo sapiens_hsa04742	0.38402836
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37302178
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33887187
86	One carbon pool by folate_Homo sapiens_hsa00670	0.33795571
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32926994
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32885149
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32788453
90	Malaria_Homo sapiens_hsa05144	0.31048925
91	RNA transport_Homo sapiens_hsa03013	0.27576771
92	Mismatch repair_Homo sapiens_hsa03430	0.27049561
93	Fatty acid degradation_Homo sapiens_hsa00071	0.26631743
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.24744826
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22992198
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.21652799
97	Insulin secretion_Homo sapiens_hsa04911	0.21593651
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.20066855
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19328108
100	GABAergic synapse_Homo sapiens_hsa04727	0.17353875

RPS15AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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