ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.54299235
2	fucose catabolic process (GO:0019317)	4.27782532
3	L-fucose metabolic process (GO:0042354)	4.27782532
4	L-fucose catabolic process (GO:0042355)	4.27782532
5	behavioral response to nicotine (GO:0035095)	4.18226080
6	centriole replication (GO:0007099)	4.16520137
7	otic vesicle formation (GO:0030916)	4.15952721
8	nonmotile primary cilium assembly (GO:0035058)	3.82256996
9	ubiquinone biosynthetic process (GO:0006744)	3.75167755
10	intraciliary transport (GO:0042073)	3.66734782
11	protein complex biogenesis (GO:0070271)	3.66089226
12	regulation of cilium movement (GO:0003352)	3.59896683
13	replication fork processing (GO:0031297)	3.48791713
14	ubiquinone metabolic process (GO:0006743)	3.48573542
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48213579
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48213579
17	cytochrome complex assembly (GO:0017004)	3.47573943
18	ribosomal small subunit assembly (GO:0000028)	3.44975037
19	platelet dense granule organization (GO:0060155)	3.43403954
20	respiratory chain complex IV assembly (GO:0008535)	3.40267176
21	viral transcription (GO:0019083)	3.36176725
22	arginine catabolic process (GO:0006527)	3.32825039
23	translational termination (GO:0006415)	3.32010874
24	protein neddylation (GO:0045116)	3.30147840
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29885427
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27081514
27	ribosomal small subunit biogenesis (GO:0042274)	3.27067141
28	auditory receptor cell differentiation (GO:0042491)	3.20387527
29	maturation of SSU-rRNA (GO:0030490)	3.19268838
30	kynurenine metabolic process (GO:0070189)	3.18104526
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16833329
32	DNA deamination (GO:0045006)	3.15883305
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.12769979
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.12769979
35	NADH dehydrogenase complex assembly (GO:0010257)	3.12769979
36	nephron tubule morphogenesis (GO:0072078)	3.10258823
37	nephron epithelium morphogenesis (GO:0072088)	3.10258823
38	axoneme assembly (GO:0035082)	3.09450440
39	tachykinin receptor signaling pathway (GO:0007217)	3.02294930
40	embryonic camera-type eye development (GO:0031076)	3.02092400
41	substrate-independent telencephalic tangential migration (GO:0021826)	3.00019336
42	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.00019336
43	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.99554032
44	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.96634292
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.96204351
46	cotranslational protein targeting to membrane (GO:0006613)	2.94544945
47	quinone biosynthetic process (GO:1901663)	2.94390426
48	chromatin remodeling at centromere (GO:0031055)	2.94155564
49	axon ensheathment in central nervous system (GO:0032291)	2.89512492
50	central nervous system myelination (GO:0022010)	2.89512492
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86295352
52	male meiosis I (GO:0007141)	2.85500094
53	protein targeting to ER (GO:0045047)	2.85440824
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82912212
55	regulation of microtubule-based movement (GO:0060632)	2.82565181
56	urogenital system development (GO:0001655)	2.82341629
57	limb bud formation (GO:0060174)	2.82115273
58	pattern specification involved in kidney development (GO:0061004)	2.81783149
59	protein polyglutamylation (GO:0018095)	2.81427635
60	mannosylation (GO:0097502)	2.79583109
61	inositol phosphate catabolic process (GO:0071545)	2.77899047
62	seminiferous tubule development (GO:0072520)	2.75716413
63	negative regulation of cAMP-mediated signaling (GO:0043951)	2.75245047
64	anterograde synaptic vesicle transport (GO:0048490)	2.74268722
65	tryptophan catabolic process (GO:0006569)	2.74217319
66	indole-containing compound catabolic process (GO:0042436)	2.74217319
67	indolalkylamine catabolic process (GO:0046218)	2.74217319
68	olfactory bulb development (GO:0021772)	2.73851179
69	translational elongation (GO:0006414)	2.71747007
70	eosinophil chemotaxis (GO:0048245)	2.69398367
71	neuron fate determination (GO:0048664)	2.68990016
72	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.68221354
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.67630719
74	protein localization to endoplasmic reticulum (GO:0070972)	2.65338157
75	terpenoid biosynthetic process (GO:0016114)	2.65294621
76	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.64985737
77	cilium organization (GO:0044782)	2.64681905
78	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.63028779
79	tongue development (GO:0043586)	2.63020394
80	epithelial cilium movement (GO:0003351)	2.62860135
81	retinal rod cell development (GO:0046548)	2.62524973
82	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.60088365
83	pyrimidine nucleobase catabolic process (GO:0006208)	2.59969792
84	estrogen biosynthetic process (GO:0006703)	2.59044853
85	forebrain neuron differentiation (GO:0021879)	2.58824967
86	positive regulation of cAMP-mediated signaling (GO:0043950)	2.58160161
87	cilium assembly (GO:0042384)	2.56774193
88	left/right axis specification (GO:0070986)	2.56433142
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55177633
90	protein localization to cilium (GO:0061512)	2.55051400
91	retinal ganglion cell axon guidance (GO:0031290)	2.54743227
92	polyol catabolic process (GO:0046174)	2.54633144
93	cilium morphogenesis (GO:0060271)	2.53956002
94	negative regulation of appetite (GO:0032099)	2.53785470
95	negative regulation of response to food (GO:0032096)	2.53785470
96	cell proliferation in forebrain (GO:0021846)	2.52800121
97	Sertoli cell development (GO:0060009)	2.52715365
98	recombinational repair (GO:0000725)	2.51916368
99	cellular biogenic amine catabolic process (GO:0042402)	2.51122817
100	amine catabolic process (GO:0009310)	2.51122817

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.30515725
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95024453
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.66120685
4	VDR_22108803_ChIP-Seq_LS180_Human	3.32701483
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.97056626
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.87147471
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37030726
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31408073
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.27197567
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22003991
11	EWS_26573619_Chip-Seq_HEK293_Human	2.19303018
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18292117
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.10480405
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06840474
15	FUS_26573619_Chip-Seq_HEK293_Human	2.04983992
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97831129
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94754312
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86570504
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.82232209
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82155633
21	P300_19829295_ChIP-Seq_ESCs_Human	1.81309742
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81178513
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77728571
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75363021
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.73145390
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71729621
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68859620
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.68187427
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.66420130
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.62833269
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59365689
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.58901100
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57553936
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57107584
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.53540977
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51944809
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.51670352
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47906171
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46272034
40	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.43017769
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40222185
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37618174
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.36969068
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35603654
45	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.35246203
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33385562
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.32694162
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32135750
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30674689
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30493469
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29440562
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26490246
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26455506
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25809124
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22500121
56	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.21716976
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20873751
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20862500
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20862500
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.17885931
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16915551
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16465412
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15614876
64	STAT3_23295773_ChIP-Seq_U87_Human	1.14948350
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14844383
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14636800
67	TCF4_23295773_ChIP-Seq_U87_Human	1.13718454
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11691514
69	AR_25329375_ChIP-Seq_VCAP_Human	1.11576260
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10649458
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09783157
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08903962
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08903962
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.08375066
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06723051
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06080833
77	CBP_20019798_ChIP-Seq_JUKART_Human	1.06080833
78	NCOR_22424771_ChIP-Seq_293T_Human	1.05863924
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05574967
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04519366
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03623727
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03623727
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02253986
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02115039
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00571299
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.99571872
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99390809
88	AR_20517297_ChIP-Seq_VCAP_Human	0.98654893
89	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98264599
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98216728
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97993022
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97503411
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97159736
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95947357
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94491971
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.94294223
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94226795
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.93494113
99	E2F7_22180533_ChIP-Seq_HELA_Human	0.92769828
100	* PHF8_20622853_ChIP-Seq_HELA_Human	0.91988972

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.25965449
2	MP0003787_abnormal_imprinting	3.12795402
3	MP0003123_paternal_imprinting	3.06325390
4	MP0006292_abnormal_olfactory_placode	2.82742443
5	MP0002163_abnormal_gland_morphology	2.74852595
6	MP0003195_calcinosis	2.71134251
7	MP0003136_yellow_coat_color	2.71121588
8	MP0000569_abnormal_digit_pigmentation	2.68693134
9	MP0003890_abnormal_embryonic-extraembry	2.50331938
10	MP0003121_genomic_imprinting	2.48301758
11	MP0002653_abnormal_ependyma_morphology	2.36198729
12	MP0009379_abnormal_foot_pigmentation	2.21471621
13	MP0005379_endocrine/exocrine_gland_phen	2.19958681
14	MP0002837_dystrophic_cardiac_calcinosis	2.13396796
15	MP0005174_abnormal_tail_pigmentation	2.13152782
16	MP0005551_abnormal_eye_electrophysiolog	2.08335588
17	MP0002938_white_spotting	1.91980052
18	MP0003122_maternal_imprinting	1.84838587
19	MP0008789_abnormal_olfactory_epithelium	1.84369109
20	MP0002095_abnormal_skin_pigmentation	1.83342728
21	MP0000372_irregular_coat_pigmentation	1.82690769
22	MP0004142_abnormal_muscle_tone	1.81607262
23	MP0001485_abnormal_pinna_reflex	1.81306723
24	MP0005084_abnormal_gallbladder_morpholo	1.80326380
25	MP0001986_abnormal_taste_sensitivity	1.80173567
26	MP0005645_abnormal_hypothalamus_physiol	1.72428304
27	MP0009780_abnormal_chondrocyte_physiolo	1.67581855
28	MP0000566_synostosis	1.67022209
29	MP0000015_abnormal_ear_pigmentation	1.62346754
30	MP0002638_abnormal_pupillary_reflex	1.62228913
31	MP0002102_abnormal_ear_morphology	1.56788402
32	MP0001293_anophthalmia	1.47183824
33	MP0002876_abnormal_thyroid_physiology	1.45983989
34	MP0000631_abnormal_neuroendocrine_gland	1.43922211
35	MP0000427_abnormal_hair_cycle	1.42549450
36	MP0000778_abnormal_nervous_system	1.42203402
37	MP0005394_taste/olfaction_phenotype	1.41767518
38	MP0005499_abnormal_olfactory_system	1.41767518
39	MP0002909_abnormal_adrenal_gland	1.40746115
40	MP0008875_abnormal_xenobiotic_pharmacok	1.40262481
41	MP0004133_heterotaxia	1.38488956
42	MP0003880_abnormal_central_pattern	1.36308446
43	MP0003950_abnormal_plasma_membrane	1.34807383
44	MP0006276_abnormal_autonomic_nervous	1.29989255
45	MP0001324_abnormal_eye_pigmentation	1.28865713
46	MP0008872_abnormal_physiological_respon	1.27099030
47	MP0005075_abnormal_melanosome_morpholog	1.25714694
48	MP0003186_abnormal_redox_activity	1.25349554
49	MP0003646_muscle_fatigue	1.24246039
50	MP0006072_abnormal_retinal_apoptosis	1.21787586
51	MP0001984_abnormal_olfaction	1.17046873
52	MP0002233_abnormal_nose_morphology	1.16616339
53	MP0005195_abnormal_posterior_eye	1.13622746
54	MP0003937_abnormal_limbs/digits/tail_de	1.10440702
55	MP0005253_abnormal_eye_physiology	1.07701272
56	MP0001529_abnormal_vocalization	1.05992212
57	MP0008775_abnormal_heart_ventricle	1.05393346
58	MP0002272_abnormal_nervous_system	1.03687728
59	MP0001968_abnormal_touch/_nociception	1.02441495
60	MP0008058_abnormal_DNA_repair	1.00343205
61	MP0002282_abnormal_trachea_morphology	0.99841196
62	MP0002557_abnormal_social/conspecific_i	0.98333014
63	MP0003936_abnormal_reproductive_system	0.97227323
64	MP0002752_abnormal_somatic_nervous	0.96381963
65	MP0002928_abnormal_bile_duct	0.93544097
66	MP0001486_abnormal_startle_reflex	0.92492954
67	MP0003718_maternal_effect	0.87840453
68	MP0002210_abnormal_sex_determination	0.86790423
69	MP0000955_abnormal_spinal_cord	0.86227502
70	MP0004134_abnormal_chest_morphology	0.84042997
71	MP0000647_abnormal_sebaceous_gland	0.83481533
72	MP0001286_abnormal_eye_development	0.83103728
73	MP0002277_abnormal_respiratory_mucosa	0.80951924
74	MP0003943_abnormal_hepatobiliary_system	0.80907358
75	MP0001944_abnormal_pancreas_morphology	0.80417591
76	MP0000538_abnormal_urinary_bladder	0.80106556
77	MP0001963_abnormal_hearing_physiology	0.79576113
78	MP0001929_abnormal_gametogenesis	0.78263298
79	MP0003938_abnormal_ear_development	0.78046300
80	MP0008995_early_reproductive_senescence	0.77351032
81	MP0003755_abnormal_palate_morphology	0.76468483
82	MP0004215_abnormal_myocardial_fiber	0.76382031
83	MP0009046_muscle_twitch	0.75554700
84	MP0006035_abnormal_mitochondrial_morpho	0.75501867
85	MP0005386_behavior/neurological_phenoty	0.73995053
86	MP0004924_abnormal_behavior	0.73995053
87	MP0003252_abnormal_bile_duct	0.72970033
88	MP0002067_abnormal_sensory_capabilities	0.72065721
89	MP0000026_abnormal_inner_ear	0.71536956
90	MP0000653_abnormal_sex_gland	0.70930192
91	MP0003567_abnormal_fetal_cardiomyocyte	0.70236293
92	MP0005310_abnormal_salivary_gland	0.70114938
93	MP0000639_abnormal_adrenal_gland	0.69450597
94	MP0001970_abnormal_pain_threshold	0.69265696
95	MP0003698_abnormal_male_reproductive	0.68953680
96	MP0009745_abnormal_behavioral_response	0.68566480
97	MP0003011_delayed_dark_adaptation	0.68323595
98	MP0002184_abnormal_innervation	0.68222557
99	MP0005220_abnormal_exocrine_pancreas	0.68116898
100	MP0004145_abnormal_muscle_electrophysio	0.66896597

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	3.91908698
2	Abnormality of midbrain morphology (HP:0002418)	3.91908698
3	True hermaphroditism (HP:0010459)	3.70513196
4	Pancreatic fibrosis (HP:0100732)	3.63841961
5	Abnormality of the labia minora (HP:0012880)	3.63265063
6	Type II lissencephaly (HP:0007260)	3.58120585
7	Pancreatic cysts (HP:0001737)	3.55266091
8	Chronic hepatic failure (HP:0100626)	3.08452307
9	Medial flaring of the eyebrow (HP:0010747)	3.07764553
10	Septo-optic dysplasia (HP:0100842)	3.07692312
11	Nephronophthisis (HP:0000090)	2.96718525
12	Acute necrotizing encephalopathy (HP:0006965)	2.92260836
13	Cerebellar dysplasia (HP:0007033)	2.91719477
14	Absent septum pellucidum (HP:0001331)	2.91430319
15	Mitochondrial inheritance (HP:0001427)	2.64574855
16	Reticulocytopenia (HP:0001896)	2.58630477
17	Intestinal atresia (HP:0011100)	2.58619178
18	Progressive macrocephaly (HP:0004481)	2.57060346
19	Optic nerve hypoplasia (HP:0000609)	2.51527818
20	Diastasis recti (HP:0001540)	2.48075560
21	Acute encephalopathy (HP:0006846)	2.43006908
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.41714757
23	Abnormality of the renal medulla (HP:0100957)	2.39646389
24	Cystic liver disease (HP:0006706)	2.34306598
25	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.31178669
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30981252
27	Abnormality of the septum pellucidum (HP:0007375)	2.30941545
28	Gait imbalance (HP:0002141)	2.29646542
29	Partial duplication of thumb phalanx (HP:0009944)	2.29525384
30	Genital tract atresia (HP:0001827)	2.29500208
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.28305217
32	Congenital primary aphakia (HP:0007707)	2.28164468
33	Colon cancer (HP:0003003)	2.24997609
34	Lipid accumulation in hepatocytes (HP:0006561)	2.23945973
35	Vaginal atresia (HP:0000148)	2.21789489
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.21564473
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.20137340
38	Hypoplastic iliac wings (HP:0002866)	2.17949521
39	Increased CSF lactate (HP:0002490)	2.16976893
40	Oligodactyly (hands) (HP:0001180)	2.16642773
41	Stenosis of the external auditory canal (HP:0000402)	2.16607233
42	Increased hepatocellular lipid droplets (HP:0006565)	2.14773668
43	Gastrointestinal atresia (HP:0002589)	2.14291498
44	Postaxial foot polydactyly (HP:0001830)	2.14198995
45	Anophthalmia (HP:0000528)	2.13414582
46	Growth hormone deficiency (HP:0000824)	2.13233261
47	Attenuation of retinal blood vessels (HP:0007843)	2.10014745
48	Hypomagnesemia (HP:0002917)	2.09095134
49	Sclerocornea (HP:0000647)	2.08147079
50	Nephrogenic diabetes insipidus (HP:0009806)	2.07429987
51	Preaxial hand polydactyly (HP:0001177)	2.04029572
52	Male pseudohermaphroditism (HP:0000037)	2.03658505
53	Rib fusion (HP:0000902)	2.02422058
54	Fibular hypoplasia (HP:0003038)	2.02191963
55	Congenital stationary night blindness (HP:0007642)	2.00763811
56	Abnormality of the diencephalon (HP:0010662)	1.99999711
57	Triphalangeal thumb (HP:0001199)	1.99237794
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.97252432
59	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96258255
60	Hypoplasia of the ulna (HP:0003022)	1.95690516
61	Esophageal atresia (HP:0002032)	1.92954212
62	Asplenia (HP:0001746)	1.92118296
63	Hypoplasia of the radius (HP:0002984)	1.91829142
64	Chromsome breakage (HP:0040012)	1.90073773
65	Decreased central vision (HP:0007663)	1.89970788
66	Glycosuria (HP:0003076)	1.89411045
67	Abnormality of urine glucose concentration (HP:0011016)	1.89411045
68	Absent thumb (HP:0009777)	1.88551674
69	Partial duplication of the phalanx of hand (HP:0009999)	1.87125014
70	Abnormal pancreas size (HP:0012094)	1.87124210
71	Anencephaly (HP:0002323)	1.85577664
72	Megalencephaly (HP:0001355)	1.85421057
73	Postaxial hand polydactyly (HP:0001162)	1.85270851
74	Sex reversal (HP:0012245)	1.85255584
75	Abnormal sex determination (HP:0012244)	1.85255584
76	Metaphyseal dysplasia (HP:0100255)	1.84113629
77	Abnormality of chromosome stability (HP:0003220)	1.82568187
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81648188
79	Abnormal number of erythroid precursors (HP:0012131)	1.81607284
80	Forearm undergrowth (HP:0009821)	1.81346069
81	Aqueductal stenosis (HP:0002410)	1.81322512
82	Meckel diverticulum (HP:0002245)	1.81053993
83	Stomach cancer (HP:0012126)	1.80590604
84	Lissencephaly (HP:0001339)	1.80091276
85	Abnormality of the ileum (HP:0001549)	1.78237427
86	Optic disc pallor (HP:0000543)	1.77410060
87	11 pairs of ribs (HP:0000878)	1.75948390
88	Bifid tongue (HP:0010297)	1.74767924
89	Narrow forehead (HP:0000341)	1.73752445
90	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.73394172
91	Dandy-Walker malformation (HP:0001305)	1.73113831
92	Neoplasm of the adrenal cortex (HP:0100641)	1.72944834
93	Tubular atrophy (HP:0000092)	1.72852769
94	Pendular nystagmus (HP:0012043)	1.71905259
95	Congenital hepatic fibrosis (HP:0002612)	1.71065498
96	Occipital encephalocele (HP:0002085)	1.70898302
97	Aganglionic megacolon (HP:0002251)	1.70196182
98	Cerebral edema (HP:0002181)	1.69636852
99	Abnormality of magnesium homeostasis (HP:0004921)	1.69030799
100	Tachypnea (HP:0002789)	1.68997432

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.51958817
2	STK38L	3.25219176
3	FRK	2.92687214
4	NUAK1	2.59050889
5	WNK3	2.45217389
6	WNK4	2.26497218
7	FGFR2	2.24819964
8	PINK1	2.24398549
9	MAP4K2	2.17456355
10	PNCK	2.07695137
11	TNIK	1.89487450
12	BMPR1B	1.84924829
13	MKNK2	1.83091222
14	STK39	1.79912642
15	MUSK	1.77903125
16	GRK1	1.71678667
17	ZAK	1.69401383
18	ADRBK2	1.69281595
19	BRSK2	1.63498921
20	TRIM28	1.62437459
21	BLK	1.54994552
22	WNK1	1.49216667
23	MKNK1	1.47612546
24	EIF2AK1	1.40628184
25	OXSR1	1.37169619
26	MAPK13	1.32435902
27	CASK	1.32312924
28	CDC7	1.28329846
29	PIK3CA	1.26690860
30	PLK2	1.26203591
31	PAK3	1.25688102
32	VRK2	1.21143894
33	PLK3	1.17392458
34	MST4	1.14503528
35	WEE1	1.11876115
36	STK3	1.11166366
37	DYRK2	1.10460994
38	TIE1	1.06793198
39	MARK3	1.06004203
40	PRKCI	1.05607539
41	NEK1	1.04772796
42	TAF1	1.00784137
43	ACVR1B	0.98662588
44	BRSK1	0.98256377
45	NME1	0.95283556
46	SRPK1	0.94982549
47	LRRK2	0.89677829
48	MAP3K12	0.89663731
49	TEC	0.86997640
50	AKT3	0.85424520
51	PRKCH	0.80692507
52	MAP3K11	0.80537468
53	PRKCG	0.80148371
54	PLK1	0.79358328
55	STK4	0.76662958
56	MAP3K4	0.76004562
57	EIF2AK3	0.75801795
58	STK11	0.75566989
59	PLK4	0.72136907
60	NEK2	0.72003374
61	TXK	0.70004101
62	ADRBK1	0.68917915
63	MINK1	0.68561286
64	VRK1	0.68205098
65	CDK19	0.68023633
66	PBK	0.66855791
67	MAP2K6	0.66014345
68	EPHA4	0.65161944
69	INSRR	0.64921772
70	DYRK3	0.63781603
71	BCR	0.63343372
72	PRKCE	0.61848948
73	CAMKK2	0.60660187
74	PDK2	0.60117669
75	CHEK2	0.60086546
76	STK38	0.58733730
77	NTRK3	0.56666835
78	DMPK	0.55810552
79	MAP2K4	0.53684364
80	PKN1	0.52149880
81	CSNK1G1	0.51444992
82	EPHB2	0.51034517
83	PRKCQ	0.50823598
84	CSNK1G2	0.49807439
85	NTRK2	0.49078221
86	GRK5	0.46521139
87	CAMK1	0.45774478
88	ERBB3	0.45636228
89	PRKACA	0.45307046
90	ATM	0.44834872
91	IKBKB	0.44205199
92	TTK	0.43661659
93	NLK	0.41359101
94	BRAF	0.41295859
95	SGK2	0.40125641
96	CSNK1A1	0.39804725
97	TGFBR1	0.38213336
98	PRKG1	0.37260196
99	CSNK1E	0.36580202
100	CSNK1G3	0.36281986

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.61882178
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.22098157
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.90388877
4	Butanoate metabolism_Homo sapiens_hsa00650	2.82821670
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78748614
6	Protein export_Homo sapiens_hsa03060	2.71397428
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.50304686
8	Homologous recombination_Homo sapiens_hsa03440	2.43189293
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.40487385
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38228923
11	Parkinsons disease_Homo sapiens_hsa05012	2.27490204
12	Phototransduction_Homo sapiens_hsa04744	2.19091251
13	Proteasome_Homo sapiens_hsa03050	2.04295120
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03145518
15	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01350376
16	Basal transcription factors_Homo sapiens_hsa03022	1.95057929
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.73577687
18	RNA polymerase_Homo sapiens_hsa03020	1.71254460
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.69632016
20	Huntingtons disease_Homo sapiens_hsa05016	1.62510219
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.61841695
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.58317158
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53100901
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49609348
25	Propanoate metabolism_Homo sapiens_hsa00640	1.45272529
26	RNA degradation_Homo sapiens_hsa03018	1.42480656
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.42475659
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.42179307
29	Peroxisome_Homo sapiens_hsa04146	1.41794094
30	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.40129696
31	Caffeine metabolism_Homo sapiens_hsa00232	1.31014944
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27460966
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.25657991
34	Alzheimers disease_Homo sapiens_hsa05010	1.21863196
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18861347
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17673906
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.16607911
38	Olfactory transduction_Homo sapiens_hsa04740	1.03791873
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03306748
40	Regulation of autophagy_Homo sapiens_hsa04140	1.01704020
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.01558802
42	Retinol metabolism_Homo sapiens_hsa00830	1.00028942
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99354468
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.95968055
45	Nicotine addiction_Homo sapiens_hsa05033	0.94407796
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93700258
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93506424
48	DNA replication_Homo sapiens_hsa03030	0.91149162
49	Sulfur metabolism_Homo sapiens_hsa00920	0.87728057
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.86548194
51	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.85184798
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84427094
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83178637
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82415533
55	Fatty acid degradation_Homo sapiens_hsa00071	0.82010899
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.81288906
57	Metabolic pathways_Homo sapiens_hsa01100	0.74310384
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73518336
59	Mismatch repair_Homo sapiens_hsa03430	0.72170278
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.71017575
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70350908
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69458403
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69294239
64	Insulin secretion_Homo sapiens_hsa04911	0.69265354
65	Glutathione metabolism_Homo sapiens_hsa00480	0.68694551
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68325089
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66856826
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66688930
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66404404
70	Purine metabolism_Homo sapiens_hsa00230	0.66293962
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65677286
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63880673
73	Sulfur relay system_Homo sapiens_hsa04122	0.63028647
74	Base excision repair_Homo sapiens_hsa03410	0.62764205
75	Fatty acid elongation_Homo sapiens_hsa00062	0.62100398
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60033303
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57669296
78	p53 signaling pathway_Homo sapiens_hsa04115	0.52854642
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.50966127
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.50551304
81	RNA transport_Homo sapiens_hsa03013	0.47295192
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46388473
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43996834
84	Serotonergic synapse_Homo sapiens_hsa04726	0.42646601
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41446630
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40895218
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39120728
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39072992
89	Asthma_Homo sapiens_hsa05310	0.38773128
90	Morphine addiction_Homo sapiens_hsa05032	0.38292608
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38280209
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37261988
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36431252
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34315263
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34216228
96	Taste transduction_Homo sapiens_hsa04742	0.33750805
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33684108
98	Circadian rhythm_Homo sapiens_hsa04710	0.33640243
99	Lysine degradation_Homo sapiens_hsa00310	0.30678652
100	One carbon pool by folate_Homo sapiens_hsa00670	0.29609646

RPS15AP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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