ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.84032495
2	viral transcription (GO:0019083)	8.50176966
3	ribosomal small subunit biogenesis (GO:0042274)	8.13248162
4	translational termination (GO:0006415)	8.12544985
5	maturation of SSU-rRNA (GO:0030490)	7.62009389
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.82145345
7	translational elongation (GO:0006414)	6.77817090
8	cotranslational protein targeting to membrane (GO:0006613)	6.74922802
9	protein targeting to ER (GO:0045047)	6.69209894
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.39503131
11	protein localization to endoplasmic reticulum (GO:0070972)	6.27993265
12	cellular protein complex disassembly (GO:0043624)	6.23469238
13	viral life cycle (GO:0019058)	6.13613729
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.98921821
15	protein complex disassembly (GO:0043241)	5.36823177
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.34208382
17	ATP synthesis coupled proton transport (GO:0015986)	5.34208382
18	translational initiation (GO:0006413)	5.09344810
19	macromolecular complex disassembly (GO:0032984)	5.08488456
20	substrate-independent telencephalic tangential migration (GO:0021826)	5.07558438
21	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.07558438
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.70218811
23	chaperone-mediated protein transport (GO:0072321)	4.64784205
24	behavioral response to nicotine (GO:0035095)	4.62134516
25	protein targeting to membrane (GO:0006612)	4.60392049
26	ribosomal large subunit biogenesis (GO:0042273)	4.53107877
27	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.21838732
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21835025
29	mRNA catabolic process (GO:0006402)	4.00646088
30	translation (GO:0006412)	3.99112899
31	cell proliferation in forebrain (GO:0021846)	3.96373449
32	respiratory electron transport chain (GO:0022904)	3.89020773
33	electron transport chain (GO:0022900)	3.87898903
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.84251796
35	NADH dehydrogenase complex assembly (GO:0010257)	3.84251796
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.84251796
37	protein complex biogenesis (GO:0070271)	3.75877960
38	protein neddylation (GO:0045116)	3.73507869
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.69522888
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.67601787
41	RNA catabolic process (GO:0006401)	3.59781564
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.56349483
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.51642899
44	nonmotile primary cilium assembly (GO:0035058)	3.47131021
45	pyrimidine nucleobase catabolic process (GO:0006208)	3.46417965
46	cellular component biogenesis (GO:0044085)	3.45533925
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.41059374
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38835778
49	tongue development (GO:0043586)	3.30367505
50	regulation of cilium movement (GO:0003352)	3.26184201
51	ATP biosynthetic process (GO:0006754)	3.22797625
52	positive regulation of T cell apoptotic process (GO:0070234)	3.17324092
53	neuron fate determination (GO:0048664)	3.16996000
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.15507230
55	establishment of protein localization to membrane (GO:0090150)	3.13268775
56	axonemal dynein complex assembly (GO:0070286)	3.09837412
57	ncRNA 3-end processing (GO:0043628)	3.09500212
58	pyrimidine nucleotide catabolic process (GO:0006244)	3.08283089
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.08247554
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.07360465
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.07360465
62	hydrogen ion transmembrane transport (GO:1902600)	3.05380550
63	somite development (GO:0061053)	3.03957466
64	protein targeting (GO:0006605)	3.00592283
65	ubiquinone biosynthetic process (GO:0006744)	2.97789365
66	epithelial cilium movement (GO:0003351)	2.96171361
67	head development (GO:0060322)	2.92710534
68	GTP biosynthetic process (GO:0006183)	2.92420978
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.88254221
70	synaptic transmission, cholinergic (GO:0007271)	2.87603120
71	central nervous system myelination (GO:0022010)	2.86106652
72	axon ensheathment in central nervous system (GO:0032291)	2.86106652
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.83376412
74	ubiquinone metabolic process (GO:0006743)	2.81359264
75	spinal cord association neuron differentiation (GO:0021527)	2.79483417
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.78086516
77	establishment of protein localization to organelle (GO:0072594)	2.76014095
78	nucleobase catabolic process (GO:0046113)	2.68990333
79	proton transport (GO:0015992)	2.67218687
80	positive regulation of respiratory burst (GO:0060267)	2.66528472
81	dentate gyrus development (GO:0021542)	2.64607744
82	hydrogen transport (GO:0006818)	2.60167528
83	regulation of microtubule-based movement (GO:0060632)	2.58622236
84	rRNA processing (GO:0006364)	2.55981376
85	cilium movement (GO:0003341)	2.55438286
86	rRNA metabolic process (GO:0016072)	2.54710285
87	protein polyglutamylation (GO:0018095)	2.54141739
88	auditory receptor cell differentiation (GO:0042491)	2.53132486
89	protein localization to membrane (GO:0072657)	2.53016123
90	negative regulation of telomere maintenance (GO:0032205)	2.51384456
91	UTP biosynthetic process (GO:0006228)	2.50232927
92	negative regulation of appetite (GO:0032099)	2.48877280
93	negative regulation of response to food (GO:0032096)	2.48877280
94	cardiovascular system development (GO:0072358)	2.47129156
95	short-term memory (GO:0007614)	2.46791984
96	positive regulation of gastrulation (GO:2000543)	2.45328872
97	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.42668468
98	retinal ganglion cell axon guidance (GO:0031290)	2.40886345
99	DNA deamination (GO:0045006)	2.40276329
100	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.38844690

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.83360181
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.68066935
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06719835
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.58269321
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58218490
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.29864270
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25749624
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20016997
9	VDR_22108803_ChIP-Seq_LS180_Human	2.16697418
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07038214
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.99204091
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.98766830
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.95335354
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.92819929
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90113455
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.89775688
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.89168939
18	XRN2_22483619_ChIP-Seq_HELA_Human	1.83704809
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.82900989
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.82624946
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.80890239
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77843524
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.74015222
24	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.70931449
25	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.70301334
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66806368
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.61056499
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.55332697
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54757374
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.54142651
31	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.54136288
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.52342343
33	CTCF_27219007_Chip-Seq_Bcells_Human	1.49711016
34	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.47185872
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43692456
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.43572056
37	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.43256826
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42766342
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42580263
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41629958
41	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.39137030
42	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.38005931
43	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.35574934
44	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.33528049
45	ERA_21632823_ChIP-Seq_H3396_Human	1.31770864
46	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.31516019
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.31018851
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30525531
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.29003437
50	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.26316118
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26294721
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24373819
53	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.23972669
54	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.23853197
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.22598766
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21920587
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.19916779
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.19916779
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18934347
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.18282994
61	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17727914
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.17636106
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17253164
64	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.17164463
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.16823079
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16254448
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.14987095
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13798352
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13071591
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12961404
71	SA1_27219007_Chip-Seq_Bcells_Human	1.11170263
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11028194
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09774135
74	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.09393008
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08371621
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07814098
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07638379
78	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06789160
79	P68_20966046_ChIP-Seq_HELA_Human	1.06480681
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06444079
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05855183
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05823798
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04908746
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.02103135
85	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01037808
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00215929
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00105613
88	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.99995127
89	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.98808984
90	NCOR_22424771_ChIP-Seq_293T_Human	0.98013937
91	EWS_26573619_Chip-Seq_HEK293_Human	0.97897034
92	BCL6_27268052_Chip-Seq_Bcells_Human	0.97887365
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97495644
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97124189
95	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.96750770
96	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.95693377
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.94579184
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94535027
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94090084
100	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.93999906

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.36658162
2	MP0006292_abnormal_olfactory_placode	4.95045686
3	MP0003787_abnormal_imprinting	3.36840020
4	MP0008789_abnormal_olfactory_epithelium	2.79894077
5	MP0003122_maternal_imprinting	2.77613343
6	MP0002653_abnormal_ependyma_morphology	2.68165994
7	MP0003123_paternal_imprinting	2.57634939
8	MP0005423_abnormal_somatic_nervous	2.45667076
9	MP0003136_yellow_coat_color	2.38757935
10	MP0005394_taste/olfaction_phenotype	2.33195324
11	MP0005499_abnormal_olfactory_system	2.33195324
12	MP0008877_abnormal_DNA_methylation	2.24554290
13	MP0005377_hearing/vestibular/ear_phenot	2.24402932
14	MP0003878_abnormal_ear_physiology	2.24402932
15	MP0004142_abnormal_muscle_tone	2.03620831
16	MP0001986_abnormal_taste_sensitivity	2.02392213
17	MP0003121_genomic_imprinting	2.02291052
18	MP0002638_abnormal_pupillary_reflex	1.99194489
19	MP0000778_abnormal_nervous_system	1.96349331
20	MP0002163_abnormal_gland_morphology	1.86693188
21	MP0006276_abnormal_autonomic_nervous	1.84235440
22	MP0001293_anophthalmia	1.70849677
23	MP0004885_abnormal_endolymph	1.69035093
24	MP0003646_muscle_fatigue	1.67007985
25	MP0001968_abnormal_touch/_nociception	1.66163943
26	MP0001485_abnormal_pinna_reflex	1.58431022
27	MP0003880_abnormal_central_pattern	1.57142926
28	MP0004147_increased_porphyrin_level	1.50631493
29	MP0005551_abnormal_eye_electrophysiolog	1.49112200
30	MP0004742_abnormal_vestibular_system	1.47018222
31	MP0000049_abnormal_middle_ear	1.46781567
32	MP0005084_abnormal_gallbladder_morpholo	1.44892876
33	MP0001188_hyperpigmentation	1.43474776
34	MP0008875_abnormal_xenobiotic_pharmacok	1.35847717
35	MP0001905_abnormal_dopamine_level	1.34325864
36	MP0005174_abnormal_tail_pigmentation	1.33689098
37	MP0000631_abnormal_neuroendocrine_gland	1.33423191
38	MP0002272_abnormal_nervous_system	1.32149043
39	MP0005195_abnormal_posterior_eye	1.30059074
40	MP0002938_white_spotting	1.28930172
41	MP0006072_abnormal_retinal_apoptosis	1.24433997
42	MP0004133_heterotaxia	1.24401564
43	MP0004145_abnormal_muscle_electrophysio	1.24326588
44	MP0000955_abnormal_spinal_cord	1.24267639
45	MP0002736_abnormal_nociception_after	1.24040494
46	MP0002095_abnormal_skin_pigmentation	1.22726969
47	MP0010030_abnormal_orbit_morphology	1.22043770
48	MP0002752_abnormal_somatic_nervous	1.20637872
49	MP0002184_abnormal_innervation	1.20388535
50	MP0002557_abnormal_social/conspecific_i	1.18758518
51	MP0001984_abnormal_olfaction	1.15583288
52	MP0002160_abnormal_reproductive_system	1.12765009
53	MP0001529_abnormal_vocalization	1.09251317
54	MP0002234_abnormal_pharynx_morphology	1.08539576
55	MP0009745_abnormal_behavioral_response	1.07977500
56	MP0000026_abnormal_inner_ear	1.07436673
57	MP0008872_abnormal_physiological_respon	1.04877430
58	MP0002233_abnormal_nose_morphology	1.04054582
59	MP0001970_abnormal_pain_threshold	1.02626335
60	MP0005389_reproductive_system_phenotype	1.00446598
61	MP0001286_abnormal_eye_development	1.00034366
62	MP0003879_abnormal_hair_cell	0.99678633
63	MP0002572_abnormal_emotion/affect_behav	0.99222725
64	MP0003938_abnormal_ear_development	0.97946816
65	MP0003890_abnormal_embryonic-extraembry	0.97388403
66	MP0005083_abnormal_biliary_tract	0.95919302
67	MP0003635_abnormal_synaptic_transmissio	0.94257115
68	MP0002102_abnormal_ear_morphology	0.93506667
69	MP0001502_abnormal_circadian_rhythm	0.92256109
70	MP0002063_abnormal_learning/memory/cond	0.92067823
71	MP0005379_endocrine/exocrine_gland_phen	0.91962223
72	MP0001919_abnormal_reproductive_system	0.90837428
73	MP0005646_abnormal_pituitary_gland	0.89498184
74	MP0002882_abnormal_neuron_morphology	0.89151850
75	MP0003942_abnormal_urinary_system	0.87771837
76	MP0002837_dystrophic_cardiac_calcinosis	0.86665213
77	MP0001963_abnormal_hearing_physiology	0.85933764
78	MP0002733_abnormal_thermal_nociception	0.85875857
79	MP0002067_abnormal_sensory_capabilities	0.85441926
80	MP0002210_abnormal_sex_determination	0.83095700
81	MP0002152_abnormal_brain_morphology	0.81262593
82	MP0002734_abnormal_mechanical_nocicepti	0.80900422
83	MP0001440_abnormal_grooming_behavior	0.80820317
84	MP0001486_abnormal_startle_reflex	0.78904920
85	MP0003315_abnormal_perineum_morphology	0.78568664
86	MP0002735_abnormal_chemical_nociception	0.77945605
87	MP0003861_abnormal_nervous_system	0.77614512
88	MP0002928_abnormal_bile_duct	0.77040774
89	MP0003755_abnormal_palate_morphology	0.76159173
90	MP0003937_abnormal_limbs/digits/tail_de	0.75794924
91	MP0004859_abnormal_synaptic_plasticity	0.74094464
92	MP0003186_abnormal_redox_activity	0.73408325
93	MP0000566_synostosis	0.70507471
94	MP0005253_abnormal_eye_physiology	0.70311835
95	MP0002876_abnormal_thyroid_physiology	0.68687948
96	MP0005645_abnormal_hypothalamus_physiol	0.68107056
97	MP0005391_vision/eye_phenotype	0.67571020
98	MP0003119_abnormal_digestive_system	0.66903558
99	MP0001324_abnormal_eye_pigmentation	0.66020776
100	MP0002277_abnormal_respiratory_mucosa	0.63281777

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.65698229
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.35954859
3	Acute necrotizing encephalopathy (HP:0006965)	4.52228551
4	Macrocytic anemia (HP:0001972)	4.12668011
5	Acute encephalopathy (HP:0006846)	4.01281474
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.96477065
7	Abnormal number of erythroid precursors (HP:0012131)	3.94502212
8	Molar tooth sign on MRI (HP:0002419)	3.68410743
9	Abnormality of midbrain morphology (HP:0002418)	3.68410743
10	Mitochondrial inheritance (HP:0001427)	3.64556304
11	Pallor (HP:0000980)	3.56145365
12	Progressive macrocephaly (HP:0004481)	3.53328971
13	Pancreatic fibrosis (HP:0100732)	3.53146091
14	Septo-optic dysplasia (HP:0100842)	3.47594495
15	Rib fusion (HP:0000902)	3.30098709
16	Absent thumb (HP:0009777)	3.20065301
17	Increased CSF lactate (HP:0002490)	3.19925707
18	Pancreatic cysts (HP:0001737)	3.00586705
19	Myokymia (HP:0002411)	2.96469036
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.94958314
21	Increased hepatocellular lipid droplets (HP:0006565)	2.91440315
22	Stenosis of the external auditory canal (HP:0000402)	2.90789022
23	Congenital stationary night blindness (HP:0007642)	2.85030567
24	Cerebral edema (HP:0002181)	2.79601411
25	Pendular nystagmus (HP:0012043)	2.79548515
26	True hermaphroditism (HP:0010459)	2.78086803
27	Lipid accumulation in hepatocytes (HP:0006561)	2.75325907
28	Nephronophthisis (HP:0000090)	2.75091711
29	Hepatocellular necrosis (HP:0001404)	2.73457138
30	Medial flaring of the eyebrow (HP:0010747)	2.69867588
31	Hyperglycinemia (HP:0002154)	2.65622810
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.61839086
33	Sclerocornea (HP:0000647)	2.55730491
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.46537770
35	Colon cancer (HP:0003003)	2.46361399
36	Hypoplasia of the radius (HP:0002984)	2.42978802
37	Optic disc pallor (HP:0000543)	2.39757899
38	Renal Fanconi syndrome (HP:0001994)	2.39514192
39	Hepatic necrosis (HP:0002605)	2.38724546
40	Asplenia (HP:0001746)	2.37356296
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.37300032
42	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.36286933
43	Anencephaly (HP:0002323)	2.36078565
44	Abnormal hemoglobin (HP:0011902)	2.34077604
45	Depressed nasal ridge (HP:0000457)	2.29599014
46	Gait imbalance (HP:0002141)	2.27908394
47	Increased intramyocellular lipid droplets (HP:0012240)	2.26879885
48	Partial duplication of thumb phalanx (HP:0009944)	2.25503200
49	Cystic liver disease (HP:0006706)	2.25446742
50	Abnormality of the renal medulla (HP:0100957)	2.21967322
51	11 pairs of ribs (HP:0000878)	2.19224688
52	Abnormality of DNA repair (HP:0003254)	2.18570490
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.17980179
54	Anophthalmia (HP:0000528)	2.17115620
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.10015371
56	Tubular atrophy (HP:0000092)	2.08624635
57	Congenital primary aphakia (HP:0007707)	2.07257503
58	Type II lissencephaly (HP:0007260)	2.07241866
59	Chronic hepatic failure (HP:0100626)	2.06748755
60	Optic nerve hypoplasia (HP:0000609)	2.03079332
61	Absent septum pellucidum (HP:0001331)	2.02646594
62	Postaxial foot polydactyly (HP:0001830)	2.01013010
63	Adrenal hypoplasia (HP:0000835)	2.00172147
64	Hypoplasia of the ulna (HP:0003022)	1.99373938
65	Abnormality of the labia minora (HP:0012880)	1.99347217
66	Forearm undergrowth (HP:0009821)	1.98439374
67	Abnormal ciliary motility (HP:0012262)	1.98378792
68	Partial duplication of the phalanx of hand (HP:0009999)	1.95777428
69	Abnormal respiratory epithelium morphology (HP:0012253)	1.94537647
70	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94537647
71	Increased serum lactate (HP:0002151)	1.94373882
72	Polydipsia (HP:0001959)	1.93912684
73	Abnormal drinking behavior (HP:0030082)	1.93912684
74	Type 2 muscle fiber atrophy (HP:0003554)	1.93701058
75	Supernumerary spleens (HP:0009799)	1.93196563
76	Nephrogenic diabetes insipidus (HP:0009806)	1.90911185
77	Increased muscle lipid content (HP:0009058)	1.90516110
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89175535
79	Lactic acidosis (HP:0003128)	1.88425572
80	Absent/shortened dynein arms (HP:0200106)	1.84066693
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84066693
82	Leukodystrophy (HP:0002415)	1.83893883
83	Chorioretinal atrophy (HP:0000533)	1.82244080
84	Maternal diabetes (HP:0009800)	1.79393790
85	Agitation (HP:0000713)	1.78868177
86	Congenital hepatic fibrosis (HP:0002612)	1.78390545
87	Abnormality of renal resorption (HP:0011038)	1.75723418
88	Male pseudohermaphroditism (HP:0000037)	1.75570067
89	Abolished electroretinogram (ERG) (HP:0000550)	1.75461902
90	Exercise intolerance (HP:0003546)	1.75025737
91	Exertional dyspnea (HP:0002875)	1.74854239
92	Polyphagia (HP:0002591)	1.73535602
93	Oligodactyly (hands) (HP:0001180)	1.73137201
94	Hyperthyroidism (HP:0000836)	1.70209491
95	Poor suck (HP:0002033)	1.69777887
96	Holoprosencephaly (HP:0001360)	1.68786000
97	Lethargy (HP:0001254)	1.68684044
98	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.68597150
99	Respiratory failure (HP:0002878)	1.67601853
100	Annular pancreas (HP:0001734)	1.67542153

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.68522066
2	STK16	3.07148831
3	DYRK2	2.98858976
4	TLK1	2.62567466
5	CDK19	2.43616914
6	ZAK	2.37416939
7	EPHB2	2.24092256
8	ADRBK2	2.08581902
9	PIK3CA	2.06153230
10	CASK	1.90635014
11	GRK1	1.87541447
12	MAP3K11	1.85711948
13	MAPK15	1.76442812
14	CDC7	1.72756608
15	EPHA4	1.68099299
16	TYRO3	1.65759786
17	WNK3	1.51731894
18	TXK	1.50887692
19	LRRK2	1.49351737
20	PRKCG	1.47498771
21	BCKDK	1.47156331
22	PINK1	1.43251830
23	TIE1	1.41228399
24	MAPK13	1.39979539
25	MAP2K7	1.39101232
26	DYRK1B	1.38941045
27	CAMK1	1.38466313
28	VRK2	1.38227425
29	CAMKK2	1.29854456
30	MARK1	1.28784817
31	STK39	1.27907659
32	NTRK2	1.24197122
33	NUAK1	1.23321403
34	PDK2	1.19841901
35	VRK1	1.19344947
36	STK11	1.17693754
37	MINK1	1.17674973
38	MUSK	1.14988304
39	BRAF	1.05799949
40	LIMK1	1.03043300
41	DAPK3	1.02659709
42	PRKCH	1.02595399
43	AURKA	0.97981578
44	MAP4K2	0.96782278
45	NEK1	0.96322097
46	MAP3K4	0.95503798
47	ADRBK1	0.94629530
48	NME2	0.94211169
49	OXSR1	0.93841931
50	BMPR1B	0.93128643
51	CAMKK1	0.85344478
52	RPS6KA5	0.83830585
53	PASK	0.82426829
54	PRKCQ	0.82229015
55	PAK3	0.79909268
56	MARK2	0.78602215
57	NTRK3	0.78592247
58	WNK1	0.76321325
59	ABL2	0.75008551
60	PRKACA	0.73970743
61	PRKCI	0.73368276
62	CAMK1D	0.72353921
63	RPS6KA6	0.72337029
64	PLK4	0.70053770
65	FRK	0.69543911
66	CSNK1G2	0.69409510
67	CHEK2	0.67706974
68	SIK2	0.67329464
69	DYRK3	0.66839621
70	CSNK2A2	0.66498287
71	AURKB	0.66450382
72	NME1	0.65808928
73	MAP2K4	0.64634573
74	PHKG2	0.64192917
75	PHKG1	0.64192917
76	KDR	0.64159138
77	PLK1	0.62781543
78	CAMK4	0.62750265
79	PRKCZ	0.61655120
80	TNIK	0.60410265
81	INSRR	0.59461735
82	OBSCN	0.58224619
83	CSNK1E	0.56559172
84	DMPK	0.54948283
85	RPS6KC1	0.54147968
86	RPS6KL1	0.54147968
87	TAF1	0.51888973
88	CDK14	0.51359694
89	CSNK1G3	0.50939292
90	PKN1	0.50567789
91	RPS6KA2	0.49616725
92	SGK223	0.48782224
93	SGK494	0.48782224
94	NEK2	0.47325381
95	SGK1	0.45822790
96	CDK11A	0.45338534
97	PRKCD	0.44756162
98	CAMK2A	0.44711963
99	MAP3K12	0.44704340
100	CSNK1A1	0.44494441

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.95673017
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.55276347
3	Parkinsons disease_Homo sapiens_hsa05012	3.94740184
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.15819133
5	Huntingtons disease_Homo sapiens_hsa05016	2.92202332
6	Alzheimers disease_Homo sapiens_hsa05010	2.61984865
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.52980121
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.51085270
9	Sulfur relay system_Homo sapiens_hsa04122	2.35793189
10	RNA polymerase_Homo sapiens_hsa03020	2.18151340
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16515031
12	Protein export_Homo sapiens_hsa03060	2.00244253
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97173062
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83209172
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57099865
16	Phototransduction_Homo sapiens_hsa04744	1.52796032
17	Nicotine addiction_Homo sapiens_hsa05033	1.44350323
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43833941
19	RNA degradation_Homo sapiens_hsa03018	1.38490784
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36694122
21	Proteasome_Homo sapiens_hsa03050	1.31041600
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30517827
23	Homologous recombination_Homo sapiens_hsa03440	1.27934928
24	One carbon pool by folate_Homo sapiens_hsa00670	1.20797040
25	Basal transcription factors_Homo sapiens_hsa03022	1.19332723
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16156734
27	Caffeine metabolism_Homo sapiens_hsa00232	1.14863013
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.14739338
29	Butanoate metabolism_Homo sapiens_hsa00650	1.10462296
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.04066924
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01322184
32	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98881175
33	Basal cell carcinoma_Homo sapiens_hsa05217	0.98845719
34	Morphine addiction_Homo sapiens_hsa05032	0.94836869
35	Peroxisome_Homo sapiens_hsa04146	0.94584851
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94159237
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.91676753
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.87947249
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86588504
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.86503706
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.83418308
42	Propanoate metabolism_Homo sapiens_hsa00640	0.80109506
43	Mismatch repair_Homo sapiens_hsa03430	0.78053761
44	Alcoholism_Homo sapiens_hsa05034	0.75047924
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74029641
46	Metabolic pathways_Homo sapiens_hsa01100	0.73027830
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68187980
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.67794699
49	DNA replication_Homo sapiens_hsa03030	0.67713938
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67373786
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67049148
52	Olfactory transduction_Homo sapiens_hsa04740	0.66883348
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63203291
54	Folate biosynthesis_Homo sapiens_hsa00790	0.61859013
55	Purine metabolism_Homo sapiens_hsa00230	0.61430173
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59957335
57	GABAergic synapse_Homo sapiens_hsa04727	0.59822294
58	Retinol metabolism_Homo sapiens_hsa00830	0.59471123
59	Insulin secretion_Homo sapiens_hsa04911	0.59112135
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57446064
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57320791
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56984575
63	Base excision repair_Homo sapiens_hsa03410	0.53876160
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53017869
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.52541805
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52432371
67	Fatty acid degradation_Homo sapiens_hsa00071	0.51872325
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.50735154
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49655147
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49373644
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48745669
72	Axon guidance_Homo sapiens_hsa04360	0.48054274
73	RNA transport_Homo sapiens_hsa03013	0.47746722
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47261843
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.45929070
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45835894
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44916851
78	Taste transduction_Homo sapiens_hsa04742	0.43772044
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.42257859
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40739480
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39588375
82	Notch signaling pathway_Homo sapiens_hsa04330	0.39290322
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39151198
84	Serotonergic synapse_Homo sapiens_hsa04726	0.38611291
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37169148
86	Spliceosome_Homo sapiens_hsa03040	0.35883941
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31237089
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31188088
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30213626
90	Regulation of autophagy_Homo sapiens_hsa04140	0.29879668
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.27717811
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26970499
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26967493
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26791304
95	Cholinergic synapse_Homo sapiens_hsa04725	0.26237788
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24308717
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.24255075
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.23015511
99	Circadian entrainment_Homo sapiens_hsa04713	0.22148825
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.19290057

RPS15AP11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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