ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	7.07637300
2	viral transcription (GO:0019083)	6.76396599
3	ribosomal small subunit assembly (GO:0000028)	6.61946842
4	translational termination (GO:0006415)	6.54319790
5	ribosomal small subunit biogenesis (GO:0042274)	6.29458875
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.45934236
7	cotranslational protein targeting to membrane (GO:0006613)	5.42889582
8	translational elongation (GO:0006414)	5.39960585
9	protein targeting to ER (GO:0045047)	5.36674251
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.19117557
11	viral life cycle (GO:0019058)	5.03267360
12	protein localization to endoplasmic reticulum (GO:0070972)	5.03026723
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.98696670
14	cellular protein complex disassembly (GO:0043624)	4.93443398
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.83391444
16	behavioral response to nicotine (GO:0035095)	4.77856447
17	cell proliferation in forebrain (GO:0021846)	4.73543054
18	protein complex disassembly (GO:0043241)	4.22413962
19	translational initiation (GO:0006413)	4.22336215
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.21040316
21	peptidyl-histidine modification (GO:0018202)	4.09542292
22	macromolecular complex disassembly (GO:0032984)	4.07592805
23	nonmotile primary cilium assembly (GO:0035058)	4.01803573
24	axoneme assembly (GO:0035082)	3.90442112
25	regulation of cilium movement (GO:0003352)	3.86271583
26	ATP synthesis coupled proton transport (GO:0015986)	3.84516347
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.84516347
28	ribosomal large subunit biogenesis (GO:0042273)	3.78852746
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68388434
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68388434
31	epithelial cilium movement (GO:0003351)	3.67347359
32	chaperone-mediated protein transport (GO:0072321)	3.64362181
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.57673074
34	somite development (GO:0061053)	3.54928800
35	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.53875602
36	substrate-independent telencephalic tangential migration (GO:0021826)	3.53875602
37	protein targeting to membrane (GO:0006612)	3.52833070
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46905264
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46905264
40	NADH dehydrogenase complex assembly (GO:0010257)	3.46905264
41	rRNA catabolic process (GO:0016075)	3.46891096
42	mRNA catabolic process (GO:0006402)	3.39670270
43	protein neddylation (GO:0045116)	3.35236245
44	translation (GO:0006412)	3.31439488
45	resolution of meiotic recombination intermediates (GO:0000712)	3.30804345
46	negative regulation of telomere maintenance (GO:0032205)	3.26197184
47	GTP biosynthetic process (GO:0006183)	3.23173849
48	protein complex biogenesis (GO:0070271)	3.21546121
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19508457
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15419630
51	glycerophospholipid catabolic process (GO:0046475)	3.15289196
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.14075204
53	response to pheromone (GO:0019236)	3.11918108
54	negative regulation of appetite (GO:0032099)	3.10561529
55	negative regulation of response to food (GO:0032096)	3.10561529
56	intraciliary transport (GO:0042073)	3.10038550
57	kidney morphogenesis (GO:0060993)	3.09988419
58	axon ensheathment in central nervous system (GO:0032291)	3.07559768
59	central nervous system myelination (GO:0022010)	3.07559768
60	neuron fate determination (GO:0048664)	3.02950159
61	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02476625
62	dentate gyrus development (GO:0021542)	3.00681260
63	RNA catabolic process (GO:0006401)	3.00496649
64	regulation of microtubule-based movement (GO:0060632)	3.00302107
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.99632736
66	ncRNA catabolic process (GO:0034661)	2.98139664
67	tongue development (GO:0043586)	2.94726240
68	ribonucleoprotein complex biogenesis (GO:0022613)	2.94062767
69	telencephalon development (GO:0021537)	2.91600089
70	cellular component biogenesis (GO:0044085)	2.89370369
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88674783
72	UTP biosynthetic process (GO:0006228)	2.80173026
73	replication fork processing (GO:0031297)	2.78731308
74	spinal cord association neuron differentiation (GO:0021527)	2.76542391
75	protein polyglutamylation (GO:0018095)	2.75168070
76	cilium movement (GO:0003341)	2.74166771
77	auditory receptor cell differentiation (GO:0042491)	2.73395436
78	CTP metabolic process (GO:0046036)	2.73277760
79	CTP biosynthetic process (GO:0006241)	2.73277760
80	fucose catabolic process (GO:0019317)	2.72692377
81	L-fucose metabolic process (GO:0042354)	2.72692377
82	L-fucose catabolic process (GO:0042355)	2.72692377
83	cilium morphogenesis (GO:0060271)	2.71795888
84	negative regulation of multicellular organism growth (GO:0040015)	2.70635475
85	body morphogenesis (GO:0010171)	2.68489331
86	electron transport chain (GO:0022900)	2.68057272
87	respiratory electron transport chain (GO:0022904)	2.67866298
88	forebrain morphogenesis (GO:0048853)	2.67737486
89	UTP metabolic process (GO:0046051)	2.63844272
90	negative regulation of astrocyte differentiation (GO:0048712)	2.63321431
91	brain morphogenesis (GO:0048854)	2.61297745
92	pyrimidine nucleotide catabolic process (GO:0006244)	2.60952817
93	parturition (GO:0007567)	2.60816020
94	axonal fasciculation (GO:0007413)	2.60110891
95	motile cilium assembly (GO:0044458)	2.59823141
96	synaptic transmission, cholinergic (GO:0007271)	2.58513844
97	embryonic body morphogenesis (GO:0010172)	2.54755353
98	piRNA metabolic process (GO:0034587)	2.53918089
99	radial glial cell differentiation (GO:0060019)	2.53661247
100	transmission of nerve impulse (GO:0019226)	2.53657200

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.69656146
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.12715008
3	VDR_22108803_ChIP-Seq_LS180_Human	2.65072464
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.64591549
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63721370
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.59796382
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.55300079
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51862763
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.37904613
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.19064125
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.13524985
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12983468
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.06291333
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.97845000
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92724492
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90133181
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.81495316
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.79062796
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75919790
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73883609
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72222245
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.68020855
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67818647
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67804394
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.67481761
26	EWS_26573619_Chip-Seq_HEK293_Human	1.64804552
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.60909837
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54679222
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.54563597
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53643186
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51810841
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.51008503
33	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.49021606
34	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.46196343
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45224790
36	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.38437889
37	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.37711526
38	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37636506
39	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.35623432
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34415488
41	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34004779
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32556690
43	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.29659475
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29578256
45	FUS_26573619_Chip-Seq_HEK293_Human	1.29419073
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27211681
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24480362
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.23323148
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.21000521
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20998605
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19607543
52	P300_19829295_ChIP-Seq_ESCs_Human	1.18558036
53	ERA_21632823_ChIP-Seq_H3396_Human	1.17295710
54	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.16655089
55	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14781301
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14574550
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13194435
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.10776749
59	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.10776749
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09808316
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09236845
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09052006
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08415076
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.08414421
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08225168
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07528798
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06498693
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06498693
69	NCOR_22424771_ChIP-Seq_293T_Human	1.06181567
70	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05764590
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04948459
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04594514
73	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03229575
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.02229838
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01772049
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00217125
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.99674623
78	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99299120
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97584036
80	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97580840
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97558070
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96267911
83	GABP_19822575_ChIP-Seq_HepG2_Human	0.95928097
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.94602868
85	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94492306
86	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.93112333
87	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.93053886
88	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92434425
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92281912
90	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.91664993
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91262763
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.90633738
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90505298
94	STAT3_23295773_ChIP-Seq_U87_Human	0.90339731
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.90089059
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89990881
97	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.89293624
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88788401
99	XRN2_22483619_ChIP-Seq_HELA_Human	0.88060455
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87455173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.58249680
2	MP0006292_abnormal_olfactory_placode	4.45107746
3	MP0003787_abnormal_imprinting	3.49225161
4	MP0008877_abnormal_DNA_methylation	2.97940260
5	MP0003122_maternal_imprinting	2.89067205
6	MP0002653_abnormal_ependyma_morphology	2.68753621
7	MP0004885_abnormal_endolymph	2.50178837
8	MP0004142_abnormal_muscle_tone	2.46701303
9	MP0003646_muscle_fatigue	2.37412776
10	MP0002102_abnormal_ear_morphology	2.31828499
11	MP0008789_abnormal_olfactory_epithelium	2.30393611
12	MP0005377_hearing/vestibular/ear_phenot	2.28153907
13	MP0003878_abnormal_ear_physiology	2.28153907
14	MP0003123_paternal_imprinting	2.22079483
15	MP0002638_abnormal_pupillary_reflex	2.14160647
16	MP0003121_genomic_imprinting	2.10543089
17	MP0002837_dystrophic_cardiac_calcinosis	2.07914946
18	MP0000778_abnormal_nervous_system	2.06646129
19	MP0010030_abnormal_orbit_morphology	2.03854719
20	MP0002163_abnormal_gland_morphology	1.95497765
21	MP0001293_anophthalmia	1.78284865
22	MP0005394_taste/olfaction_phenotype	1.78075799
23	MP0005499_abnormal_olfactory_system	1.78075799
24	MP0001485_abnormal_pinna_reflex	1.66719402
25	MP0000631_abnormal_neuroendocrine_gland	1.62554644
26	MP0005551_abnormal_eye_electrophysiolog	1.57853704
27	MP0002938_white_spotting	1.57579765
28	MP0000049_abnormal_middle_ear	1.56854217
29	MP0002272_abnormal_nervous_system	1.48523844
30	MP0006072_abnormal_retinal_apoptosis	1.47110768
31	MP0008872_abnormal_physiological_respon	1.47041265
32	MP0006276_abnormal_autonomic_nervous	1.46579982
33	MP0005084_abnormal_gallbladder_morpholo	1.40710150
34	MP0005195_abnormal_posterior_eye	1.36015710
35	MP0004043_abnormal_pH_regulation	1.35643445
36	MP0004742_abnormal_vestibular_system	1.34053783
37	MP0004133_heterotaxia	1.25347900
38	MP0003937_abnormal_limbs/digits/tail_de	1.25165409
39	MP0001968_abnormal_touch/_nociception	1.23940557
40	MP0002557_abnormal_social/conspecific_i	1.22378275
41	MP0000026_abnormal_inner_ear	1.22191103
42	MP0002876_abnormal_thyroid_physiology	1.21841054
43	MP0004145_abnormal_muscle_electrophysio	1.17560572
44	MP0002095_abnormal_skin_pigmentation	1.17375072
45	MP0002752_abnormal_somatic_nervous	1.16794682
46	MP0000955_abnormal_spinal_cord	1.16405967
47	MP0005360_urolithiasis	1.15103908
48	MP0008875_abnormal_xenobiotic_pharmacok	1.14076529
49	MP0001286_abnormal_eye_development	1.13965315
50	MP0000372_irregular_coat_pigmentation	1.12696608
51	MP0003136_yellow_coat_color	1.12136060
52	MP0003938_abnormal_ear_development	1.09926187
53	MP0008775_abnormal_heart_ventricle	1.08187589
54	MP0001984_abnormal_olfaction	1.08000402
55	MP0002234_abnormal_pharynx_morphology	1.05830382
56	MP0002184_abnormal_innervation	1.05339455
57	MP0002736_abnormal_nociception_after	1.02133347
58	MP0003186_abnormal_redox_activity	0.99659207
59	MP0001970_abnormal_pain_threshold	0.98970636
60	MP0009745_abnormal_behavioral_response	0.98391318
61	MP0002233_abnormal_nose_morphology	0.95929600
62	MP0001986_abnormal_taste_sensitivity	0.95561556
63	MP0002734_abnormal_mechanical_nocicepti	0.95243935
64	MP0005646_abnormal_pituitary_gland	0.94938437
65	MP0002733_abnormal_thermal_nociception	0.94711231
66	MP0001502_abnormal_circadian_rhythm	0.92869717
67	MP0009046_muscle_twitch	0.92316616
68	MP0002572_abnormal_emotion/affect_behav	0.91467133
69	MP0008057_abnormal_DNA_replication	0.90680866
70	MP0003635_abnormal_synaptic_transmissio	0.90060946
71	MP0003567_abnormal_fetal_cardiomyocyte	0.89765556
72	MP0000427_abnormal_hair_cycle	0.88081796
73	MP0002735_abnormal_chemical_nociception	0.87573813
74	MP0001963_abnormal_hearing_physiology	0.87564099
75	MP0002210_abnormal_sex_determination	0.87322814
76	MP0003861_abnormal_nervous_system	0.86491683
77	MP0005379_endocrine/exocrine_gland_phen	0.85607362
78	MP0003942_abnormal_urinary_system	0.84496373
79	MP0005075_abnormal_melanosome_morpholog	0.82202301
80	MP0001486_abnormal_startle_reflex	0.81887262
81	MP0002152_abnormal_brain_morphology	0.81455989
82	MP0005389_reproductive_system_phenotype	0.81029184
83	MP0003755_abnormal_palate_morphology	0.80848970
84	MP0002063_abnormal_learning/memory/cond	0.80601169
85	MP0003693_abnormal_embryo_hatching	0.80002441
86	MP0002882_abnormal_neuron_morphology	0.79766880
87	MP0001663_abnormal_digestive_system	0.79191433
88	MP0002160_abnormal_reproductive_system	0.78219047
89	MP0004147_increased_porphyrin_level	0.77702245
90	MP0001346_abnormal_lacrimal_gland	0.74596281
91	MP0003195_calcinosis	0.73273773
92	MP0001944_abnormal_pancreas_morphology	0.73173070
93	MP0010386_abnormal_urinary_bladder	0.72546068
94	MP0003890_abnormal_embryonic-extraembry	0.72450879
95	MP0002067_abnormal_sensory_capabilities	0.71703003
96	MP0002928_abnormal_bile_duct	0.71186667
97	MP0003879_abnormal_hair_cell	0.70915775
98	MP0000653_abnormal_sex_gland	0.70371512
99	MP0001324_abnormal_eye_pigmentation	0.70010476
100	MP0008058_abnormal_DNA_repair	0.69547139

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.28797401
2	Pancreatic fibrosis (HP:0100732)	4.24624139
3	Molar tooth sign on MRI (HP:0002419)	4.13946991
4	Abnormality of midbrain morphology (HP:0002418)	4.13946991
5	Acute necrotizing encephalopathy (HP:0006965)	3.81315570
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.73572189
7	True hermaphroditism (HP:0010459)	3.42051319
8	Pancreatic cysts (HP:0001737)	3.36657025
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.35903429
10	Nephronophthisis (HP:0000090)	3.34253265
11	Acute encephalopathy (HP:0006846)	3.34042432
12	Medial flaring of the eyebrow (HP:0010747)	3.33992160
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20389919
14	Abnormality of DNA repair (HP:0003254)	3.08432400
15	Macrocytic anemia (HP:0001972)	3.04357881
16	Colon cancer (HP:0003003)	3.02445563
17	Chronic hepatic failure (HP:0100626)	2.98452159
18	Progressive macrocephaly (HP:0004481)	2.97247058
19	Absent thumb (HP:0009777)	2.90041021
20	Asplenia (HP:0001746)	2.86234062
21	Abnormality of the renal medulla (HP:0100957)	2.85508632
22	Mitochondrial inheritance (HP:0001427)	2.83760840
23	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.81360853
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.81308479
25	Gait imbalance (HP:0002141)	2.72265151
26	Type II lissencephaly (HP:0007260)	2.63704401
27	Hepatocellular necrosis (HP:0001404)	2.62147123
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.61475947
29	Absent/shortened dynein arms (HP:0200106)	2.61475947
30	Stenosis of the external auditory canal (HP:0000402)	2.59881187
31	Congenital primary aphakia (HP:0007707)	2.59639981
32	Pallor (HP:0000980)	2.55193764
33	Increased CSF lactate (HP:0002490)	2.52304817
34	Septo-optic dysplasia (HP:0100842)	2.51512819
35	Abnormality of the labia minora (HP:0012880)	2.48221795
36	Cystic liver disease (HP:0006706)	2.47123608
37	Nephrogenic diabetes insipidus (HP:0009806)	2.45089115
38	Pendular nystagmus (HP:0012043)	2.43632303
39	Abnormal number of erythroid precursors (HP:0012131)	2.41843689
40	Hepatic necrosis (HP:0002605)	2.39525671
41	Postaxial foot polydactyly (HP:0001830)	2.38252372
42	Abnormality of the renal cortex (HP:0011035)	2.34817033
43	Abnormal respiratory motile cilium morphology (HP:0005938)	2.34422353
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.34422353
45	Cerebral edema (HP:0002181)	2.34012467
46	Cerebellar dysplasia (HP:0007033)	2.29728374
47	Tubular atrophy (HP:0000092)	2.27414084
48	Anencephaly (HP:0002323)	2.26703282
49	Abolished electroretinogram (ERG) (HP:0000550)	2.26438802
50	Supernumerary spleens (HP:0009799)	2.19908623
51	Congenital hepatic fibrosis (HP:0002612)	2.19168145
52	Poor coordination (HP:0002370)	2.19088203
53	Optic disc pallor (HP:0000543)	2.16910443
54	Arthropathy (HP:0003040)	2.13492276
55	Hypoplasia of the pons (HP:0012110)	2.12348065
56	Partial duplication of thumb phalanx (HP:0009944)	2.11865039
57	Myokymia (HP:0002411)	2.11299358
58	Sclerocornea (HP:0000647)	2.08066930
59	Decreased central vision (HP:0007663)	2.04894920
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.04772271
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04747128
62	Genital tract atresia (HP:0001827)	2.02607288
63	Congenital stationary night blindness (HP:0007642)	2.00041327
64	Abnormal biliary tract physiology (HP:0012439)	1.99499102
65	Bile duct proliferation (HP:0001408)	1.99499102
66	Vaginal atresia (HP:0000148)	1.97792775
67	Papilledema (HP:0001085)	1.96466612
68	Depressed nasal ridge (HP:0000457)	1.95643134
69	Ectopic kidney (HP:0000086)	1.94230585
70	Postaxial hand polydactyly (HP:0001162)	1.93210112
71	Horseshoe kidney (HP:0000085)	1.92049609
72	Hyperglycinemia (HP:0002154)	1.91844781
73	Triphalangeal thumb (HP:0001199)	1.91051482
74	Adrenal hypoplasia (HP:0000835)	1.89456334
75	Male pseudohermaphroditism (HP:0000037)	1.88685037
76	Abnormal ciliary motility (HP:0012262)	1.87767587
77	Abnormality of the pons (HP:0007361)	1.87469786
78	Agitation (HP:0000713)	1.86852186
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85655056
80	Hypoplasia of the ulna (HP:0003022)	1.84637007
81	Optic nerve hypoplasia (HP:0000609)	1.84516786
82	Narrow forehead (HP:0000341)	1.82428410
83	Oligodactyly (hands) (HP:0001180)	1.80559971
84	Leukodystrophy (HP:0002415)	1.79742378
85	Abnormal drinking behavior (HP:0030082)	1.79702264
86	Polydipsia (HP:0001959)	1.79702264
87	Preaxial hand polydactyly (HP:0001177)	1.79486320
88	Volvulus (HP:0002580)	1.78757025
89	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.78275394
90	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.78275394
91	Holoprosencephaly (HP:0001360)	1.78124207
92	Abnormality of the ileum (HP:0001549)	1.77275535
93	Pachygyria (HP:0001302)	1.77197942
94	Abnormality of the corticospinal tract (HP:0002492)	1.75988575
95	Duplication of thumb phalanx (HP:0009942)	1.73182871
96	Retinitis pigmentosa (HP:0000510)	1.69145445
97	Renal dysplasia (HP:0000110)	1.69055631
98	Aganglionic megacolon (HP:0002251)	1.68053252
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.66851426
100	Meckel diverticulum (HP:0002245)	1.64655536

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.36049481
2	MAP4K2	2.97841568
3	CDK19	2.67861923
4	BMPR1B	2.38370154
5	STK39	2.31034057
6	PINK1	2.26526379
7	NUAK1	2.24736371
8	CASK	2.24009954
9	PIK3CA	2.13778441
10	CDC7	2.08271724
11	DYRK2	2.07061650
12	EPHB2	2.02953311
13	TNIK	2.01144833
14	NME1	1.84356995
15	GRK1	1.76661027
16	ZAK	1.67117121
17	ADRBK2	1.65861988
18	INSRR	1.53605931
19	CAMKK2	1.47614689
20	FRK	1.47318937
21	BCKDK	1.45565714
22	MAP3K9	1.43461705
23	MKNK2	1.41657939
24	STK16	1.39201455
25	CAMK1D	1.39196821
26	CDK8	1.37372516
27	EPHA4	1.37193800
28	TGFBR1	1.36352272
29	OXSR1	1.33848857
30	TIE1	1.28543358
31	CAMK1G	1.26624915
32	NTRK2	1.26289356
33	MAP2K7	1.26159036
34	CAMK1	1.22906651
35	PRKCG	1.20624852
36	TLK1	1.19321104
37	PDK2	1.18025834
38	MAP3K4	1.15004792
39	DYRK1B	1.13917553
40	VRK2	1.13310824
41	STK11	1.06118186
42	LIMK1	1.01975747
43	PLK4	0.96662287
44	NEK2	0.91936583
45	ACVR1B	0.91316640
46	MAPK13	0.89290145
47	TAOK3	0.85047670
48	MARK1	0.85017331
49	PRKCE	0.82856059
50	VRK1	0.79293930
51	WNK1	0.79248498
52	WNK3	0.79127344
53	CCNB1	0.77130365
54	MAP3K12	0.76498135
55	TAF1	0.76468598
56	ADRBK1	0.76411155
57	PRKCH	0.75667519
58	PNCK	0.73233088
59	RPS6KA6	0.72517620
60	PLK1	0.71327373
61	CHEK2	0.67756036
62	LRRK2	0.67616427
63	PLK2	0.67407070
64	MARK3	0.65550422
65	MAP3K11	0.65452247
66	PRKCQ	0.63062756
67	IKBKB	0.62131775
68	MARK2	0.62019510
69	PASK	0.61247345
70	DAPK3	0.60866798
71	MAPK15	0.60102978
72	NEK1	0.59515567
73	AURKB	0.58864108
74	TYRO3	0.58229571
75	PRKACA	0.58170681
76	NME2	0.58010530
77	AURKA	0.56954944
78	CSNK2A2	0.56786019
79	RPS6KL1	0.56207257
80	RPS6KC1	0.56207257
81	PLK3	0.55891795
82	PIK3CG	0.55778596
83	CAMKK1	0.55111104
84	ATR	0.53819489
85	CAMK4	0.52420043
86	TRIM28	0.51817798
87	STK3	0.51035777
88	BRAF	0.50476100
89	PRKCI	0.50091303
90	CSNK1A1	0.49970225
91	RPS6KB2	0.47675652
92	PRKCZ	0.46035836
93	MAPKAPK5	0.44678885
94	UHMK1	0.44038686
95	ATM	0.42845036
96	SIK2	0.42214061
97	NTRK3	0.41871887
98	SGK1	0.41772991
99	MAP2K4	0.41305146
100	MKNK1	0.40936461

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.07131496
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.61900399
3	Parkinsons disease_Homo sapiens_hsa05012	3.06360421
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.39109384
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.37538565
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.32348654
7	Protein export_Homo sapiens_hsa03060	2.31837444
8	Huntingtons disease_Homo sapiens_hsa05016	2.27108602
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24538043
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10542498
11	Butanoate metabolism_Homo sapiens_hsa00650	1.96483920
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.96317866
13	Alzheimers disease_Homo sapiens_hsa05010	1.95688091
14	Homologous recombination_Homo sapiens_hsa03440	1.84842906
15	RNA degradation_Homo sapiens_hsa03018	1.80697966
16	RNA polymerase_Homo sapiens_hsa03020	1.74595288
17	Basal transcription factors_Homo sapiens_hsa03022	1.57720955
18	Nicotine addiction_Homo sapiens_hsa05033	1.55403767
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54697516
20	Base excision repair_Homo sapiens_hsa03410	1.49392306
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.48084108
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.47039241
23	Propanoate metabolism_Homo sapiens_hsa00640	1.41851854
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40404466
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37385270
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.33424487
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32806154
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.26339286
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25437661
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.24817970
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.22606622
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22444012
33	Sulfur relay system_Homo sapiens_hsa04122	1.20556475
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17838457
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14641280
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14057571
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13463777
38	Phototransduction_Homo sapiens_hsa04744	1.10948204
39	Folate biosynthesis_Homo sapiens_hsa00790	1.10940963
40	Peroxisome_Homo sapiens_hsa04146	1.07666594
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.06384361
42	Mismatch repair_Homo sapiens_hsa03430	1.05946621
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99771851
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.96313192
45	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.95603852
46	Insulin secretion_Homo sapiens_hsa04911	0.94844628
47	RNA transport_Homo sapiens_hsa03013	0.93859919
48	Fatty acid degradation_Homo sapiens_hsa00071	0.93063669
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87654478
50	Olfactory transduction_Homo sapiens_hsa04740	0.87019051
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81463681
52	DNA replication_Homo sapiens_hsa03030	0.81244155
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79376601
54	One carbon pool by folate_Homo sapiens_hsa00670	0.79277191
55	Metabolic pathways_Homo sapiens_hsa01100	0.78779627
56	Morphine addiction_Homo sapiens_hsa05032	0.78581793
57	Caffeine metabolism_Homo sapiens_hsa00232	0.78087883
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77669553
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.77306153
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.73325116
61	Purine metabolism_Homo sapiens_hsa00230	0.68759574
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67242600
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67067420
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64068337
65	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.63943907
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.63049053
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61641413
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.60572447
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.59946099
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.56516111
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54116684
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54069191
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.50904082
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50425966
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50079617
76	Axon guidance_Homo sapiens_hsa04360	0.49737692
77	Taste transduction_Homo sapiens_hsa04742	0.49414746
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48715463
79	Retinol metabolism_Homo sapiens_hsa00830	0.44747569
80	Fatty acid elongation_Homo sapiens_hsa00062	0.44668270
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43894861
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43175578
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43162498
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40536191
85	Salivary secretion_Homo sapiens_hsa04970	0.40243967
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38224690
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37585736
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.37565114
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36690443
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36364641
91	Spliceosome_Homo sapiens_hsa03040	0.34261169
92	Cholinergic synapse_Homo sapiens_hsa04725	0.33969528
93	Proteasome_Homo sapiens_hsa03050	0.33925004
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.32750508
95	Serotonergic synapse_Homo sapiens_hsa04726	0.31903329
96	GABAergic synapse_Homo sapiens_hsa04727	0.31009486
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29612261
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28893036
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28512944
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26488226

RPS15AP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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