ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.88601261
2	regulation of cilium movement (GO:0003352)	4.80186438
3	platelet dense granule organization (GO:0060155)	4.66750794
4	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.27186494
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.27186494
6	NADH dehydrogenase complex assembly (GO:0010257)	4.27186494
7	protein complex biogenesis (GO:0070271)	4.26625187
8	nonmotile primary cilium assembly (GO:0035058)	3.79806516
9	kidney morphogenesis (GO:0060993)	3.79228283
10	mitochondrial respiratory chain complex assembly (GO:0033108)	3.78112973
11	preassembly of GPI anchor in ER membrane (GO:0016254)	3.68040489
12	resolution of meiotic recombination intermediates (GO:0000712)	3.62368828
13	intraciliary transport (GO:0042073)	3.55858272
14	gamma-aminobutyric acid transport (GO:0015812)	3.54236760
15	somite development (GO:0061053)	3.52847281
16	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.49728473
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.44534661
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.42352216
19	neurofilament cytoskeleton organization (GO:0060052)	3.39539848
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.32504186
21	DNA double-strand break processing (GO:0000729)	3.27340643
22	cholesterol biosynthetic process (GO:0006695)	3.26676241
23	replication fork processing (GO:0031297)	3.21105082
24	meiotic chromosome segregation (GO:0045132)	3.20344818
25	estrogen biosynthetic process (GO:0006703)	3.18970933
26	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.18325113
27	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.18325113
28	oxidative demethylation (GO:0070989)	3.14766429
29	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.13299790
30	substrate-independent telencephalic tangential migration (GO:0021826)	3.13299790
31	metaphase plate congression (GO:0051310)	3.05922343
32	cilium morphogenesis (GO:0060271)	3.02383564
33	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.00141913
34	cardiac right ventricle morphogenesis (GO:0003215)	2.96652376
35	head development (GO:0060322)	2.95623304
36	pyrimidine nucleobase catabolic process (GO:0006208)	2.93938256
37	amine catabolic process (GO:0009310)	2.92902871
38	cellular biogenic amine catabolic process (GO:0042402)	2.92902871
39	regulation of microtubule-based movement (GO:0060632)	2.92251469
40	DNA damage response, detection of DNA damage (GO:0042769)	2.90757396
41	epithelial cilium movement (GO:0003351)	2.90273991
42	synaptic transmission, cholinergic (GO:0007271)	2.88423528
43	positive regulation of respiratory burst (GO:0060267)	2.88373029
44	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.87426109
45	sterol biosynthetic process (GO:0016126)	2.85791603
46	GPI anchor metabolic process (GO:0006505)	2.85470834
47	neural tube formation (GO:0001841)	2.82158141
48	protein polyglutamylation (GO:0018095)	2.82070129
49	response to pheromone (GO:0019236)	2.81389124
50	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.81108634
51	telencephalon development (GO:0021537)	2.81088681
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.80034967
53	detection of light stimulus involved in visual perception (GO:0050908)	2.78728885
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.78728885
55	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.77588153
56	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.77244101
57	isotype switching (GO:0045190)	2.77244101
58	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.77244101
59	C-terminal protein lipidation (GO:0006501)	2.77215026
60	cell proliferation in forebrain (GO:0021846)	2.75265072
61	GTP biosynthetic process (GO:0006183)	2.73293709
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68416992
63	ubiquinone metabolic process (GO:0006743)	2.68085451
64	anterograde synaptic vesicle transport (GO:0048490)	2.67759140
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66993973
66	photoreceptor cell development (GO:0042461)	2.65874876
67	positive regulation of organelle assembly (GO:1902117)	2.61169880
68	ubiquinone biosynthetic process (GO:0006744)	2.61051649
69	C-terminal protein amino acid modification (GO:0018410)	2.60146621
70	respiratory chain complex IV assembly (GO:0008535)	2.59882070
71	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.58329253
72	sulfation (GO:0051923)	2.57743956
73	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.56013238
74	nephron epithelium morphogenesis (GO:0072088)	2.55317268
75	nephron tubule morphogenesis (GO:0072078)	2.55317268
76	smoothened signaling pathway (GO:0007224)	2.54692008
77	myoblast migration (GO:0051451)	2.54442582
78	neuron fate determination (GO:0048664)	2.53941140
79	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.53265350
80	somite rostral/caudal axis specification (GO:0032525)	2.52833141
81	photoreceptor cell maintenance (GO:0045494)	2.49802781
82	cytochrome complex assembly (GO:0017004)	2.48950272
83	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.48111177
84	anterograde axon cargo transport (GO:0008089)	2.45738599
85	inner ear receptor stereocilium organization (GO:0060122)	2.45534793
86	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.44810752
87	negative regulation of DNA recombination (GO:0045910)	2.44619466
88	regulation of hexokinase activity (GO:1903299)	2.44426223
89	regulation of glucokinase activity (GO:0033131)	2.44426223
90	Sertoli cell development (GO:0060009)	2.43964196
91	response to oxygen radical (GO:0000305)	2.43618677
92	estrogen metabolic process (GO:0008210)	2.41551894
93	transmission of nerve impulse (GO:0019226)	2.41166957
94	kinetochore organization (GO:0051383)	2.41071956
95	eye photoreceptor cell development (GO:0042462)	2.39556590
96	alkaloid metabolic process (GO:0009820)	2.39526897
97	retinal cone cell development (GO:0046549)	2.39322763
98	urogenital system development (GO:0001655)	2.38859138
99	single strand break repair (GO:0000012)	2.38272688
100	regulation of timing of cell differentiation (GO:0048505)	2.38071267

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.32737113
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.73370170
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.35260442
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08927832
5	VDR_22108803_ChIP-Seq_LS180_Human	2.73260650
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60933671
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.60143506
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41746453
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.39478612
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31029372
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27234950
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25195671
13	P300_19829295_ChIP-Seq_ESCs_Human	2.21746176
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.15932970
15	EWS_26573619_Chip-Seq_HEK293_Human	2.15289664
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.08564912
17	FUS_26573619_Chip-Seq_HEK293_Human	2.03676361
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.02599016
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97056301
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91563306
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89896645
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.89477346
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.89477346
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.87526008
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77773533
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.74871668
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66448941
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66410056
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.65075155
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63013910
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61453435
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60136538
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59597194
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.59455859
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58984054
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.55569402
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51626925
38	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50525519
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49524092
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48684673
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46719891
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45844362
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45478827
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44885623
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42058868
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36965755
47	STAT3_23295773_ChIP-Seq_U87_Human	1.35576441
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32939813
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.32660813
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31987946
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31006399
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30713287
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29616987
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29381235
55	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.22650674
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22083177
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.21016989
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20232168
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19354904
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.17293029
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17107466
62	TCF4_23295773_ChIP-Seq_U87_Human	1.16481332
63	AR_25329375_ChIP-Seq_VCAP_Human	1.15095578
64	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14741535
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13039300
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12139360
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.09523916
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09125947
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08903112
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08903112
71	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06077822
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05952761
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05952761
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05324435
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04382398
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.04381505
77	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03617024
78	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03407607
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03407607
80	JUN_21703547_ChIP-Seq_K562_Human	1.03156297
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02848883
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02560740
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01608612
84	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00404380
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.00308261
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00291502
87	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99790312
88	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.99675009
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99083315
90	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.98530942
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98374261
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.97453213
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94698473
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94515496
95	NCOR_22424771_ChIP-Seq_293T_Human	0.93262871
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.93127804
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92743210
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92165481
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91820759
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91472604

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.09797973
2	MP0005423_abnormal_somatic_nervous	3.45105397
3	MP0000372_irregular_coat_pigmentation	3.20811533
4	MP0002163_abnormal_gland_morphology	2.83972741
5	MP0008789_abnormal_olfactory_epithelium	2.75489508
6	MP0001348_abnormal_lacrimal_gland	2.68139923
7	MP0002837_dystrophic_cardiac_calcinosis	2.52405546
8	MP0005379_endocrine/exocrine_gland_phen	2.31995929
9	MP0004133_heterotaxia	2.28720997
10	MP0003880_abnormal_central_pattern	2.16497379
11	MP0005394_taste/olfaction_phenotype	2.11437861
12	MP0005499_abnormal_olfactory_system	2.11437861
13	MP0003890_abnormal_embryonic-extraembry	2.01488163
14	MP0002938_white_spotting	1.90869289
15	MP0002102_abnormal_ear_morphology	1.88325736
16	MP0000778_abnormal_nervous_system	1.87546651
17	MP0001529_abnormal_vocalization	1.85991656
18	MP0001346_abnormal_lacrimal_gland	1.85752498
19	MP0003121_genomic_imprinting	1.83019332
20	MP0005551_abnormal_eye_electrophysiolog	1.82163467
21	MP0003787_abnormal_imprinting	1.77694065
22	MP0005646_abnormal_pituitary_gland	1.73231904
23	MP0006276_abnormal_autonomic_nervous	1.67573609
24	MP0003122_maternal_imprinting	1.62788711
25	MP0008872_abnormal_physiological_respon	1.57926919
26	MP0001293_anophthalmia	1.56440711
27	MP0003195_calcinosis	1.55736014
28	MP0001984_abnormal_olfaction	1.53412783
29	MP0008875_abnormal_xenobiotic_pharmacok	1.53302540
30	MP0005248_abnormal_Harderian_gland	1.51476820
31	MP0000569_abnormal_digit_pigmentation	1.51378917
32	MP0002653_abnormal_ependyma_morphology	1.51259224
33	MP0008877_abnormal_DNA_methylation	1.50306023
34	MP0003119_abnormal_digestive_system	1.46138343
35	MP0004145_abnormal_muscle_electrophysio	1.43376634
36	MP0002557_abnormal_social/conspecific_i	1.42103290
37	MP0010030_abnormal_orbit_morphology	1.41290325
38	MP0006072_abnormal_retinal_apoptosis	1.38089315
39	MP0004142_abnormal_muscle_tone	1.37478158
40	MP0002735_abnormal_chemical_nociception	1.35080360
41	MP0003937_abnormal_limbs/digits/tail_de	1.34885920
42	MP0005084_abnormal_gallbladder_morpholo	1.32982358
43	MP0008995_early_reproductive_senescence	1.32596672
44	MP0005174_abnormal_tail_pigmentation	1.32287838
45	MP0002876_abnormal_thyroid_physiology	1.31688748
46	MP0001485_abnormal_pinna_reflex	1.30246554
47	MP0000427_abnormal_hair_cycle	1.29047182
48	MP0002928_abnormal_bile_duct	1.28550426
49	MP0002233_abnormal_nose_morphology	1.28088940
50	MP0003011_delayed_dark_adaptation	1.25152230
51	MP0003950_abnormal_plasma_membrane	1.24946205
52	MP0001986_abnormal_taste_sensitivity	1.24850199
53	MP0000631_abnormal_neuroendocrine_gland	1.24180570
54	MP0003567_abnormal_fetal_cardiomyocyte	1.23254069
55	MP0002277_abnormal_respiratory_mucosa	1.22279510
56	MP0005253_abnormal_eye_physiology	1.19917552
57	MP0002272_abnormal_nervous_system	1.19758906
58	MP0010386_abnormal_urinary_bladder	1.19629592
59	MP0002160_abnormal_reproductive_system	1.19195958
60	MP0002736_abnormal_nociception_after	1.18963920
61	MP0000049_abnormal_middle_ear	1.17482550
62	MP0002254_reproductive_system_inflammat	1.16834285
63	MP0003646_muscle_fatigue	1.11295358
64	MP0005389_reproductive_system_phenotype	1.10263621
65	MP0003786_premature_aging	1.08992727
66	MP0005195_abnormal_posterior_eye	1.08914883
67	MP0001299_abnormal_eye_distance/	1.06873500
68	MP0001440_abnormal_grooming_behavior	1.06179463
69	MP0001970_abnormal_pain_threshold	1.03826922
70	MP0002752_abnormal_somatic_nervous	1.00533015
71	MP0008058_abnormal_DNA_repair	1.00278833
72	MP0001968_abnormal_touch/_nociception	0.98017698
73	MP0002095_abnormal_skin_pigmentation	0.97695449
74	MP0003755_abnormal_palate_morphology	0.95449469
75	MP0002572_abnormal_emotion/affect_behav	0.95073228
76	MP0002210_abnormal_sex_determination	0.94145024
77	MP0005670_abnormal_white_adipose	0.92342824
78	MP0002734_abnormal_mechanical_nocicepti	0.92155243
79	MP0000955_abnormal_spinal_cord	0.91895599
80	MP0002282_abnormal_trachea_morphology	0.91085466
81	MP0008775_abnormal_heart_ventricle	0.90923889
82	MP0000026_abnormal_inner_ear	0.90778707
83	MP0001486_abnormal_startle_reflex	0.90754511
84	MP0001119_abnormal_female_reproductive	0.86572911
85	MP0002184_abnormal_innervation	0.85566822
86	MP0009745_abnormal_behavioral_response	0.85316205
87	MP0000604_amyloidosis	0.82452930
88	MP0001919_abnormal_reproductive_system	0.81946477
89	MP0005410_abnormal_fertilization	0.81804509
90	MP0005391_vision/eye_phenotype	0.80526396
91	MP0002090_abnormal_vision	0.78342299
92	MP0004924_abnormal_behavior	0.78128516
93	MP0005386_behavior/neurological_phenoty	0.78128516
94	MP0009053_abnormal_anal_canal	0.76205353
95	MP0004885_abnormal_endolymph	0.75810702
96	MP0000015_abnormal_ear_pigmentation	0.74944177
97	MP0000653_abnormal_sex_gland	0.74103780
98	MP0001286_abnormal_eye_development	0.73234554
99	MP0003936_abnormal_reproductive_system	0.71717050
100	MP0004742_abnormal_vestibular_system	0.70542798

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.26297843
2	Colon cancer (HP:0003003)	4.14797688
3	Pancreatic fibrosis (HP:0100732)	4.05050759
4	Pancreatic cysts (HP:0001737)	3.72512245
5	Molar tooth sign on MRI (HP:0002419)	3.62743206
6	Abnormality of midbrain morphology (HP:0002418)	3.62743206
7	Medial flaring of the eyebrow (HP:0010747)	3.35641195
8	Hepatocellular necrosis (HP:0001404)	3.28977075
9	Acute necrotizing encephalopathy (HP:0006965)	3.28106884
10	Chronic hepatic failure (HP:0100626)	3.19197837
11	Anencephaly (HP:0002323)	3.19065903
12	Supernumerary spleens (HP:0009799)	3.12731908
13	Nephronophthisis (HP:0000090)	3.11217601
14	Gait imbalance (HP:0002141)	3.08039476
15	Hypoplastic pelvis (HP:0008839)	3.04782929
16	Congenital primary aphakia (HP:0007707)	3.04004473
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.01424357
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.96205139
19	Abnormality of the labia minora (HP:0012880)	2.94531260
20	Mitochondrial inheritance (HP:0001427)	2.87365209
21	Nephrogenic diabetes insipidus (HP:0009806)	2.85841202
22	Acute encephalopathy (HP:0006846)	2.85566550
23	Hip dysplasia (HP:0001385)	2.84944662
24	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.79652835
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.78727269
26	Abnormality of the renal medulla (HP:0100957)	2.77955129
27	Asplenia (HP:0001746)	2.74714971
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.68352043
29	Progressive macrocephaly (HP:0004481)	2.62472356
30	Increased CSF lactate (HP:0002490)	2.54100996
31	Hepatic necrosis (HP:0002605)	2.54044044
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.47826985
33	Dyschromatopsia (HP:0007641)	2.46401571
34	Cystic liver disease (HP:0006706)	2.41815216
35	Short tibia (HP:0005736)	2.36311900
36	Genital tract atresia (HP:0001827)	2.27922554
37	Vaginal atresia (HP:0000148)	2.26946103
38	3-Methylglutaconic aciduria (HP:0003535)	2.24926556
39	Abolished electroretinogram (ERG) (HP:0000550)	2.24866595
40	Postaxial foot polydactyly (HP:0001830)	2.23893059
41	Sclerocornea (HP:0000647)	2.23337923
42	Abnormal biliary tract physiology (HP:0012439)	2.21337781
43	Bile duct proliferation (HP:0001408)	2.21337781
44	Absent septum pellucidum (HP:0001331)	2.15829343
45	Intestinal atresia (HP:0011100)	2.10497020
46	Congenital hepatic fibrosis (HP:0002612)	2.09380365
47	Preaxial hand polydactyly (HP:0001177)	2.09176775
48	Poor coordination (HP:0002370)	2.09073697
49	Male pseudohermaphroditism (HP:0000037)	2.02940288
50	Cerebral edema (HP:0002181)	2.01650947
51	Abnormal pancreas size (HP:0012094)	2.01461202
52	Hyperventilation (HP:0002883)	1.99956385
53	Small hand (HP:0200055)	1.98812176
54	Broad-based gait (HP:0002136)	1.98487728
55	Optic disc pallor (HP:0000543)	1.98045282
56	Adrenal hypoplasia (HP:0000835)	1.96782123
57	Sloping forehead (HP:0000340)	1.96717274
58	Hyperglycinemia (HP:0002154)	1.96417100
59	Abnormality of the corticospinal tract (HP:0002492)	1.96039236
60	Decreased central vision (HP:0007663)	1.95278564
61	Neoplasm of the adrenal cortex (HP:0100641)	1.93400023
62	Nasal speech (HP:0001611)	1.93358358
63	Abnormality of the pons (HP:0007361)	1.93194307
64	Postaxial hand polydactyly (HP:0001162)	1.93079734
65	Type 2 muscle fiber atrophy (HP:0003554)	1.89401798
66	Septo-optic dysplasia (HP:0100842)	1.89359230
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88083803
68	Narrow forehead (HP:0000341)	1.86812978
69	Abnormality of the ileum (HP:0001549)	1.85331504
70	Abnormality of the ischium (HP:0003174)	1.84930602
71	Abnormality of the renal cortex (HP:0011035)	1.84008048
72	Dandy-Walker malformation (HP:0001305)	1.83271089
73	Pendular nystagmus (HP:0012043)	1.83162743
74	Emotional lability (HP:0000712)	1.82238572
75	Congenital stationary night blindness (HP:0007642)	1.82200790
76	Parakeratosis (HP:0001036)	1.81681483
77	Oligodactyly (hands) (HP:0001180)	1.81574021
78	CNS demyelination (HP:0007305)	1.79471418
79	Aganglionic megacolon (HP:0002251)	1.79393237
80	Abnormality of the parathyroid morphology (HP:0011766)	1.79355111
81	Decreased muscle mass (HP:0003199)	1.78491260
82	Astigmatism (HP:0000483)	1.78199874
83	Febrile seizures (HP:0002373)	1.77665141
84	Pachygyria (HP:0001302)	1.76030879
85	Short foot (HP:0001773)	1.75115855
86	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.75072170
87	Aplasia of the musculature (HP:0100854)	1.74605724
88	Meckel diverticulum (HP:0002245)	1.74315884
89	Respiratory failure (HP:0002878)	1.72371821
90	Oligohydramnios (HP:0001562)	1.71095354
91	Volvulus (HP:0002580)	1.70389834
92	Attenuation of retinal blood vessels (HP:0007843)	1.69834640
93	Aqueductal stenosis (HP:0002410)	1.69802086
94	Abnormal lung lobation (HP:0002101)	1.69595334
95	Furrowed tongue (HP:0000221)	1.69360299
96	Keratoconus (HP:0000563)	1.69135609
97	Increased corneal curvature (HP:0100692)	1.69135609
98	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.68208703
99	X-linked dominant inheritance (HP:0001423)	1.66864562
100	Specific learning disability (HP:0001328)	1.66064462

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.24300945
2	TRIM28	3.20852429
3	MST4	2.91041576
4	FRK	2.70045978
5	PNCK	2.69009139
6	BCR	2.42201006
7	PAK3	2.39676160
8	PBK	2.25755236
9	STK39	2.17018326
10	WNK4	2.14239055
11	MKNK2	2.07277657
12	PLK4	2.02251265
13	BMPR1B	1.92746755
14	MARK1	1.77353678
15	SRPK1	1.76716533
16	TNIK	1.70857276
17	NUAK1	1.64843173
18	PLK3	1.62316904
19	MAP4K2	1.60168601
20	VRK1	1.56594452
21	EIF2AK3	1.47055669
22	ADRBK2	1.41987171
23	TAF1	1.41358910
24	CAMKK2	1.33891448
25	PINK1	1.30796392
26	PLK2	1.29771876
27	DYRK2	1.28124367
28	MAP3K4	1.24645887
29	MAP3K12	1.19202121
30	ERBB3	1.18583592
31	FER	1.14365659
32	EPHB2	1.11947256
33	LMTK2	1.11830895
34	CDC7	1.10677189
35	WEE1	1.09992334
36	MAPK13	1.09787647
37	MAP2K7	1.07980611
38	VRK2	1.07392084
39	PIK3CA	1.06302262
40	GRK1	1.05136811
41	MKNK1	1.02364697
42	BCKDK	0.99892725
43	ZAK	0.99790757
44	BRSK2	0.98615228
45	CAMK1G	0.98070607
46	SIK3	0.95546516
47	TTK	0.95232643
48	INSRR	0.94440317
49	MAP3K10	0.94173192
50	CASK	0.88406669
51	OXSR1	0.87660793
52	CDK19	0.87553200
53	PDK2	0.86183293
54	PRKCG	0.81961620
55	ADRBK1	0.81614886
56	TSSK6	0.81340796
57	BUB1	0.80919906
58	MAPK15	0.79934217
59	ACVR1B	0.79082044
60	GRK7	0.79059695
61	CAMK1	0.78434145
62	CSNK1G1	0.76696557
63	MINK1	0.75806667
64	CSNK1G2	0.71704472
65	TGFBR1	0.69635365
66	CSNK1A1L	0.68738443
67	PRKCE	0.67879351
68	PRKCI	0.66661852
69	CSNK1G3	0.66390132
70	PLK1	0.65886488
71	EPHA4	0.62696090
72	CHEK2	0.59050281
73	DYRK1B	0.57756188
74	CCNB1	0.56727721
75	NME1	0.54873119
76	TIE1	0.52537385
77	LIMK1	0.52203618
78	PRKACA	0.50980884
79	BRAF	0.49450015
80	DYRK3	0.48285429
81	FGFR1	0.47833301
82	NTRK2	0.44939834
83	PRKAA1	0.41788326
84	WNK1	0.41092644
85	PRKG1	0.40785734
86	GSK3A	0.40088401
87	STK11	0.39135822
88	ATR	0.38290347
89	FGFR2	0.37631022
90	DYRK1A	0.37424772
91	ERBB4	0.36909149
92	NEK6	0.36707333
93	CSNK1A1	0.36433818
94	CAMK1D	0.35026141
95	EIF2AK2	0.33949963
96	SGK494	0.33255786
97	SGK223	0.33255786
98	NEK1	0.33174452
99	LRRK2	0.33082605
100	MYLK	0.32958676

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.99196707
2	Protein export_Homo sapiens_hsa03060	3.19656392
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.11835379
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.88310512
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.73112976
6	Proteasome_Homo sapiens_hsa03050	2.60373576
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.42265280
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32295107
9	Caffeine metabolism_Homo sapiens_hsa00232	2.14354116
10	Parkinsons disease_Homo sapiens_hsa05012	2.12272038
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09729315
12	Basal transcription factors_Homo sapiens_hsa03022	1.93812548
13	Phototransduction_Homo sapiens_hsa04744	1.93457743
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77496100
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76657744
16	Fatty acid elongation_Homo sapiens_hsa00062	1.71917746
17	RNA polymerase_Homo sapiens_hsa03020	1.63933153
18	Homologous recombination_Homo sapiens_hsa03440	1.62212768
19	Ribosome_Homo sapiens_hsa03010	1.61391693
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.57272173
21	Nicotine addiction_Homo sapiens_hsa05033	1.56016570
22	Propanoate metabolism_Homo sapiens_hsa00640	1.53441191
23	RNA degradation_Homo sapiens_hsa03018	1.52600854
24	Butanoate metabolism_Homo sapiens_hsa00650	1.49391360
25	Huntingtons disease_Homo sapiens_hsa05016	1.44802607
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39559987
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36136753
28	Regulation of autophagy_Homo sapiens_hsa04140	1.33886790
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31955325
30	Peroxisome_Homo sapiens_hsa04146	1.31730905
31	Alzheimers disease_Homo sapiens_hsa05010	1.26681160
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.23103670
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22900865
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22040352
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.20598768
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19790773
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15058164
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.14914136
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13357041
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.10840715
41	One carbon pool by folate_Homo sapiens_hsa00670	1.10344451
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09293514
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06648166
44	Retinol metabolism_Homo sapiens_hsa00830	1.06097075
45	Basal cell carcinoma_Homo sapiens_hsa05217	1.04423199
46	Circadian rhythm_Homo sapiens_hsa04710	1.02542993
47	GABAergic synapse_Homo sapiens_hsa04727	0.92634765
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.88656518
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87380970
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.85590985
51	Mismatch repair_Homo sapiens_hsa03430	0.85466173
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82692936
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82350190
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81292746
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80348623
56	Taste transduction_Homo sapiens_hsa04742	0.79191497
57	Fatty acid degradation_Homo sapiens_hsa00071	0.77461457
58	Asthma_Homo sapiens_hsa05310	0.76491057
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73478854
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.73258827
61	RNA transport_Homo sapiens_hsa03013	0.72465454
62	Sulfur relay system_Homo sapiens_hsa04122	0.70782302
63	Morphine addiction_Homo sapiens_hsa05032	0.68946914
64	Glutathione metabolism_Homo sapiens_hsa00480	0.67605282
65	Olfactory transduction_Homo sapiens_hsa04740	0.66896753
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65006506
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64431391
68	Base excision repair_Homo sapiens_hsa03410	0.63252524
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60033738
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.59974241
71	ABC transporters_Homo sapiens_hsa02010	0.59183526
72	Metabolic pathways_Homo sapiens_hsa01100	0.57020780
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56445155
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.55574809
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.55538062
76	Insulin secretion_Homo sapiens_hsa04911	0.53406911
77	Axon guidance_Homo sapiens_hsa04360	0.52933531
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52397107
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52293804
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51967306
81	Purine metabolism_Homo sapiens_hsa00230	0.51740151
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51479903
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50003011
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.49498484
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.44941614
86	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.44593586
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43602732
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42237707
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41493183
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40783201
91	Serotonergic synapse_Homo sapiens_hsa04726	0.40710837
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40604633
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.39328396
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38664835
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38013102
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36837594
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.35875135
98	Mineral absorption_Homo sapiens_hsa04978	0.35733553
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34844680
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.32622261

RPS15AP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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