RPS15AP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1segment specification (GO:0007379)7.59333959
2behavioral response to nicotine (GO:0035095)6.61996826
3positive regulation of vascular permeability (GO:0043117)6.36163601
4positive regulation of action potential (GO:0045760)6.13234470
5tachykinin receptor signaling pathway (GO:0007217)6.08843839
6tyrosine phosphorylation of STAT protein (GO:0007260)5.27167340
7synaptic transmission, cholinergic (GO:0007271)5.16748873
8viral transcription (GO:0019083)5.14860207
9ovulation cycle (GO:0042698)5.13164458
10cytoplasmic mRNA processing body assembly (GO:0033962)5.05709286
11translational termination (GO:0006415)4.95809980
12aggressive behavior (GO:0002118)4.94751001
13regulation of bile acid biosynthetic process (GO:0070857)4.42871064
14substrate-independent telencephalic tangential migration (GO:0021826)4.39429116
15substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.39429116
16regulation of action potential (GO:0098900)4.34287035
17regulation of female gonad development (GO:2000194)4.10882911
18behavioral response to ethanol (GO:0048149)4.08108213
19response to pheromone (GO:0019236)4.07767799
20regulation of transmission of nerve impulse (GO:0051969)4.07339941
21pyrimidine nucleobase catabolic process (GO:0006208)4.04614660
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01401312
23drinking behavior (GO:0042756)3.97579353
24cotranslational protein targeting to membrane (GO:0006613)3.96799678
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95510967
26protein targeting to ER (GO:0045047)3.95215709
27olfactory bulb development (GO:0021772)3.92422550
28nonmotile primary cilium assembly (GO:0035058)3.91076630
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90453519
30auditory receptor cell differentiation (GO:0042491)3.88167239
31somite development (GO:0061053)3.87638620
32translational elongation (GO:0006414)3.87327497
33positive regulation of uterine smooth muscle contraction (GO:0070474)3.86682771
34viral life cycle (GO:0019058)3.81079562
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.79732569
36cellular protein complex disassembly (GO:0043624)3.79730084
37neuron fate determination (GO:0048664)3.78227900
38ribosomal small subunit assembly (GO:0000028)3.75810032
39response to auditory stimulus (GO:0010996)3.71260789
40protein localization to endoplasmic reticulum (GO:0070972)3.70428207
41positive regulation of neurological system process (GO:0031646)3.66953442
42response to morphine (GO:0043278)3.65183651
43postsynaptic membrane organization (GO:0001941)3.58659741
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57597696
45ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.55543039
46response to isoquinoline alkaloid (GO:0014072)3.52579669
47ganglion development (GO:0061548)3.46367619
48water-soluble vitamin biosynthetic process (GO:0042364)3.46006104
49ribosomal small subunit biogenesis (GO:0042274)3.45908420
50terpenoid biosynthetic process (GO:0016114)3.44739812
51maturation of SSU-rRNA (GO:0030490)3.39616348
52positive regulation of digestive system process (GO:0060456)3.36567802
53protein complex disassembly (GO:0043241)3.26130634
54nucleobase catabolic process (GO:0046113)3.25340939
55neuronal stem cell maintenance (GO:0097150)3.15536917
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14432960
57epithelial cilium movement (GO:0003351)3.13583797
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11032263
59regulation of translation, ncRNA-mediated (GO:0045974)3.09262813
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09262813
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.09262813
62tongue development (GO:0043586)3.09100476
63head development (GO:0060322)3.07689528
64intraciliary transport (GO:0042073)3.06832251
65endoderm formation (GO:0001706)3.06540086
66eating behavior (GO:0042755)3.05404844
67regulation of microtubule-based movement (GO:0060632)3.05262474
68regulation of uterine smooth muscle contraction (GO:0070472)3.05064401
69urinary tract smooth muscle contraction (GO:0014848)3.05009077
70regulation of cilium movement (GO:0003352)3.03209663
71macromolecular complex disassembly (GO:0032984)3.02659751
72negative regulation of astrocyte differentiation (GO:0048712)2.99202124
73translational initiation (GO:0006413)2.98495930
74transmission of nerve impulse (GO:0019226)2.95765884
75startle response (GO:0001964)2.94662062
76spinal cord development (GO:0021510)2.93131222
77axon ensheathment in central nervous system (GO:0032291)2.90766875
78central nervous system myelination (GO:0022010)2.90766875
79cell proliferation in forebrain (GO:0021846)2.83375628
80negative regulation of oligodendrocyte differentiation (GO:0048715)2.83251978
81positive regulation of growth hormone secretion (GO:0060124)2.78450459
82regulation of gene silencing by RNA (GO:0060966)2.77947641
83regulation of posttranscriptional gene silencing (GO:0060147)2.77947641
84regulation of gene silencing by miRNA (GO:0060964)2.77947641
85negative regulation of potassium ion transport (GO:0043267)2.73783887
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.67985078
87neuron recognition (GO:0008038)2.65890192
88mechanosensory behavior (GO:0007638)2.65854594
89limb development (GO:0060173)2.63319003
90appendage development (GO:0048736)2.63319003
91protein targeting to membrane (GO:0006612)2.60006192
92acrosome reaction (GO:0007340)2.59651866
93hypothalamus development (GO:0021854)2.57392939
94regulation of timing of cell differentiation (GO:0048505)2.55868427
95regulation of growth hormone secretion (GO:0060123)2.53614567
96negative regulation of protein tyrosine kinase activity (GO:0061099)2.53009125
97mRNA catabolic process (GO:0006402)2.52307977
98cerebral cortex radially oriented cell migration (GO:0021799)2.52141330
99spinal cord association neuron differentiation (GO:0021527)2.51860233
100pattern specification involved in kidney development (GO:0061004)10.7221527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.92846453
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.02151670
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75370729
4GBX2_23144817_ChIP-Seq_PC3_Human2.65554039
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.64126858
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42520406
7ZNF274_21170338_ChIP-Seq_K562_Hela2.41110579
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36607047
9VDR_22108803_ChIP-Seq_LS180_Human2.30951347
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29930471
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.29113403
12REST_21632747_ChIP-Seq_MESCs_Mouse2.16803649
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14042376
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07175629
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90469671
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.89444800
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.87122889
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.84744074
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.84459751
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80364555
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77519954
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.75458746
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69280246
24CBP_20019798_ChIP-Seq_JUKART_Human1.69280246
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65802767
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64946390
27RNF2_27304074_Chip-Seq_NSC_Mouse1.64129903
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63892702
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61533378
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59316090
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59316090
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58185508
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52977200
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51621465
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46784675
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45231366
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44758394
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.41524855
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39296661
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36518459
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35768971
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33390490
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32663479
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30908071
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30203018
46P300_19829295_ChIP-Seq_ESCs_Human1.28628286
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27589927
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27084209
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27084209
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.26309120
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24535885
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22208851
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21693776
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21575322
55DROSHA_22980978_ChIP-Seq_HELA_Human1.17432202
56BCAT_22108803_ChIP-Seq_LS180_Human1.17359556
57SMAD3_21741376_ChIP-Seq_ESCs_Human1.16709051
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15479220
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.14763945
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12627982
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.10254447
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10101873
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.07898302
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.07738349
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07247475
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06571593
67IRF1_19129219_ChIP-ChIP_H3396_Human1.05630096
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04537976
69FUS_26573619_Chip-Seq_HEK293_Human1.03882301
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02979911
71CTCF_27219007_Chip-Seq_Bcells_Human1.02246616
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01336686
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00195403
74GATA1_26923725_Chip-Seq_HPCs_Mouse0.99260287
75MYC_18940864_ChIP-ChIP_HL60_Human0.98542011
76AR_25329375_ChIP-Seq_VCAP_Human0.98477981
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98294983
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.97661545
79KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97374845
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.96721140
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95531107
82WDR5_24793694_ChIP-Seq_LNCAP_Human0.95205076
83TP53_22573176_ChIP-Seq_HFKS_Human0.94618188
84NCOR_22424771_ChIP-Seq_293T_Human0.94278328
85EST1_17652178_ChIP-ChIP_JURKAT_Human0.94262153
86IGF1R_20145208_ChIP-Seq_DFB_Human0.94205519
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93784334
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.90815836
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89544301
90ER_23166858_ChIP-Seq_MCF-7_Human0.88381545
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.87796441
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87307287
93RUNX2_22187159_ChIP-Seq_PCA_Human0.86350911
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86091016
95TCF4_22108803_ChIP-Seq_LS180_Human0.86023369
96AR_19668381_ChIP-Seq_PC3_Human0.85712061
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.84754892
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.84601714
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83354499
100NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83148744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.77904383
2MP0002736_abnormal_nociception_after3.59814537
3MP0003122_maternal_imprinting3.47853112
4MP0005646_abnormal_pituitary_gland3.38459507
5MP0009379_abnormal_foot_pigmentation3.31296346
6MP0006292_abnormal_olfactory_placode3.00697656
7MP0001968_abnormal_touch/_nociception2.92139343
8MP0003315_abnormal_perineum_morphology2.74468884
9MP0000778_abnormal_nervous_system2.60000956
10MP0001529_abnormal_vocalization2.58130541
11MP0008789_abnormal_olfactory_epithelium2.41142696
12MP0003121_genomic_imprinting2.37641470
13MP0003879_abnormal_hair_cell2.35546785
14MP0002277_abnormal_respiratory_mucosa2.26583711
15MP0005394_taste/olfaction_phenotype2.17552262
16MP0005499_abnormal_olfactory_system2.17552262
17MP0002735_abnormal_chemical_nociception2.08442309
18MP0008877_abnormal_DNA_methylation2.06474959
19MP0000613_abnormal_salivary_gland2.06146902
20MP0002653_abnormal_ependyma_morphology1.97937910
21MP0001984_abnormal_olfaction1.95378158
22MP0003123_paternal_imprinting1.95214102
23MP0005187_abnormal_penis_morphology1.94906829
24MP0002102_abnormal_ear_morphology1.92548160
25MP0003646_muscle_fatigue1.82646016
26MP0003136_yellow_coat_color1.72244224
27MP0002163_abnormal_gland_morphology1.68944299
28MP0001348_abnormal_lacrimal_gland1.65572613
29MP0004133_heterotaxia1.63590389
30MP0004859_abnormal_synaptic_plasticity1.62051587
31MP0002557_abnormal_social/conspecific_i1.53455743
32MP0001293_anophthalmia1.45304327
33MP0009745_abnormal_behavioral_response1.42893570
34MP0004142_abnormal_muscle_tone1.42548407
35MP0002272_abnormal_nervous_system1.42382914
36MP0009046_muscle_twitch1.38677151
37MP0002572_abnormal_emotion/affect_behav1.36231466
38MP0002734_abnormal_mechanical_nocicepti1.36013566
39MP0003635_abnormal_synaptic_transmissio1.35397846
40MP0008872_abnormal_physiological_respon1.34768292
41MP0002234_abnormal_pharynx_morphology1.33587607
42MP0001485_abnormal_pinna_reflex1.32148345
43MP0000049_abnormal_middle_ear1.30809556
44MP0002876_abnormal_thyroid_physiology1.30443924
45MP0000631_abnormal_neuroendocrine_gland1.30196980
46MP0000955_abnormal_spinal_cord1.27656790
47MP0002067_abnormal_sensory_capabilities1.27482188
48MP0002063_abnormal_learning/memory/cond1.25117860
49MP0002837_dystrophic_cardiac_calcinosis1.24192834
50MP0002938_white_spotting1.21257414
51MP0004885_abnormal_endolymph1.20612996
52MP0002184_abnormal_innervation1.16649654
53MP0006072_abnormal_retinal_apoptosis1.14267530
54MP0001502_abnormal_circadian_rhythm1.13229073
55MP0005248_abnormal_Harderian_gland1.12696061
56MP0005195_abnormal_posterior_eye1.11768392
57MP0006276_abnormal_autonomic_nervous1.11628408
58MP0001440_abnormal_grooming_behavior1.10078235
59MP0005551_abnormal_eye_electrophysiolog1.09781044
60MP0000372_irregular_coat_pigmentation1.08705547
61MP0003880_abnormal_central_pattern1.07959978
62MP0002254_reproductive_system_inflammat1.07155229
63MP0001970_abnormal_pain_threshold1.04666855
64MP0008875_abnormal_xenobiotic_pharmacok1.03978202
65MP0002752_abnormal_somatic_nervous1.03294058
66MP0000026_abnormal_inner_ear1.01529579
67MP0003755_abnormal_palate_morphology1.01111509
68MP0004147_increased_porphyrin_level1.00336465
69MP0000566_synostosis0.99867774
70MP0001286_abnormal_eye_development0.97819596
71MP0004742_abnormal_vestibular_system0.96190754
72MP0004130_abnormal_muscle_cell0.95381910
73MP0003878_abnormal_ear_physiology0.93719326
74MP0005377_hearing/vestibular/ear_phenot0.93719326
75MP0005367_renal/urinary_system_phenotyp0.92785825
76MP0000516_abnormal_urinary_system0.92785825
77MP0004924_abnormal_behavior0.91637994
78MP0005386_behavior/neurological_phenoty0.91637994
79MP0001486_abnormal_startle_reflex0.91051471
80MP0002233_abnormal_nose_morphology0.89927177
81MP0002882_abnormal_neuron_morphology0.87059230
82MP0003890_abnormal_embryonic-extraembry0.85721770
83MP0003942_abnormal_urinary_system0.84973858
84MP0002064_seizures0.83240476
85MP0003283_abnormal_digestive_organ0.82631005
86MP0001324_abnormal_eye_pigmentation0.81115505
87MP0002152_abnormal_brain_morphology0.80488673
88MP0009780_abnormal_chondrocyte_physiolo0.77784404
89MP0003861_abnormal_nervous_system0.76903564
90MP0003937_abnormal_limbs/digits/tail_de0.75168748
91MP0002138_abnormal_hepatobiliary_system0.73998080
92MP0005379_endocrine/exocrine_gland_phen0.72056192
93MP0002095_abnormal_skin_pigmentation0.71162090
94MP0001963_abnormal_hearing_physiology0.69258569
95MP0003115_abnormal_respiratory_system0.68830485
96MP0003938_abnormal_ear_development0.68534728
97MP0003959_abnormal_lean_body0.67566544
98MP0002733_abnormal_thermal_nociception0.66026801
99MP0005423_abnormal_somatic_nervous0.64452612
100MP0001542_abnormal_bone_strength0.63632465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.19443695
2Molar tooth sign on MRI (HP:0002419)4.19443695
3Septo-optic dysplasia (HP:0100842)3.84162705
4Pancreatic fibrosis (HP:0100732)3.55640615
5Thyroid-stimulating hormone excess (HP:0002925)3.51976725
6Nephronophthisis (HP:0000090)3.37371089
7Oligodactyly (hands) (HP:0001180)3.33411641
8Hypogonadotrophic hypogonadism (HP:0000044)3.12846605
9Anosmia (HP:0000458)3.11990922
10Type II lissencephaly (HP:0007260)3.10289181
11Pancreatic cysts (HP:0001737)3.09867377
12Abnormality of cells of the erythroid lineage (HP:0012130)3.06604469
13Papilledema (HP:0001085)3.00109584
14Medial flaring of the eyebrow (HP:0010747)2.98706396
15Hepatoblastoma (HP:0002884)2.81668759
16Abnormality of the labia minora (HP:0012880)2.78286013
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76230566
18True hermaphroditism (HP:0010459)2.74207386
19Abnormality of the renal medulla (HP:0100957)2.73776483
20Down-sloping shoulders (HP:0200021)2.68479830
21Reticulocytopenia (HP:0001896)2.66471748
22Stenosis of the external auditory canal (HP:0000402)2.65729429
23Polyphagia (HP:0002591)2.64167299
24Urinary bladder sphincter dysfunction (HP:0002839)2.63613893
25Gait imbalance (HP:0002141)2.63340389
26Chronic hepatic failure (HP:0100626)2.57666550
27Oligodactyly (HP:0012165)2.56881773
28Colon cancer (HP:0003003)2.54635530
29Anophthalmia (HP:0000528)2.52840889
30Diastasis recti (HP:0001540)2.49476557
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.47679388
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47679388
33Optic nerve hypoplasia (HP:0000609)2.46505881
34Acute necrotizing encephalopathy (HP:0006965)2.45107731
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44620318
36Absent septum pellucidum (HP:0001331)2.42762220
37Abnormality of the corticospinal tract (HP:0002492)2.42150379
38Pendular nystagmus (HP:0012043)2.41987062
39Abnormal number of erythroid precursors (HP:0012131)2.41273547
40Postaxial foot polydactyly (HP:0001830)2.40438474
41Limb dystonia (HP:0002451)2.37057119
42Maternal diabetes (HP:0009800)2.37053223
43Asplenia (HP:0001746)2.36783034
44Agitation (HP:0000713)2.35191754
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.33185958
46Cystic liver disease (HP:0006706)2.23431302
47Neoplasm of the adrenal cortex (HP:0100641)2.20927764
48Horseshoe kidney (HP:0000085)2.19648717
49Hypoplasia of the radius (HP:0002984)2.19543979
50Postaxial hand polydactyly (HP:0001162)2.19092099
51Lissencephaly (HP:0001339)2.16887147
52Genetic anticipation (HP:0003743)2.15845757
53Abnormal eating behavior (HP:0100738)2.15424830
54Anencephaly (HP:0002323)2.14567475
55Congenital hepatic fibrosis (HP:0002612)2.14562032
56Growth hormone deficiency (HP:0000824)2.13335543
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12257284
58Cerebellar dysplasia (HP:0007033)2.11921733
59Congenital primary aphakia (HP:0007707)2.11364247
60Macrocytic anemia (HP:0001972)2.08099814
61Forearm undergrowth (HP:0009821)2.08040455
62Depressed nasal ridge (HP:0000457)2.07170609
63Abnormal rod and cone electroretinograms (HP:0008323)2.07167358
64Spinal muscular atrophy (HP:0007269)2.07006051
65Narrow forehead (HP:0000341)2.06013938
66Progressive cerebellar ataxia (HP:0002073)2.03532238
67Nephrogenic diabetes insipidus (HP:0009806)2.03064200
68Increased corneal curvature (HP:0100692)2.02524555
69Keratoconus (HP:0000563)2.02524555
70Sclerocornea (HP:0000647)2.01445359
71Pallor (HP:0000980)2.00476877
72Hypoplasia of the ulna (HP:0003022)1.99663324
73Abnormal mitochondria in muscle tissue (HP:0008316)1.99535440
74Progressive macrocephaly (HP:0004481)1.99076908
75Deep palmar crease (HP:0006191)1.96491363
76Congenital malformation of the right heart (HP:0011723)1.95605851
77Double outlet right ventricle (HP:0001719)1.95605851
78Shawl scrotum (HP:0000049)1.93915277
79Ectopic kidney (HP:0000086)1.93826422
80Intestinal atresia (HP:0011100)1.92684704
81Facial cleft (HP:0002006)1.88828193
82Pachygyria (HP:0001302)1.87371150
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87133611
84Focal seizures (HP:0007359)1.86832131
85Acute encephalopathy (HP:0006846)1.86703441
86Adrenal hypoplasia (HP:0000835)1.86588331
87Abnormality of the septum pellucidum (HP:0007375)1.86133102
88Fibular hypoplasia (HP:0003038)1.85661214
89Midline defect of the nose (HP:0004122)1.85524985
90High anterior hairline (HP:0009890)1.85464887
91Broad distal phalanx of finger (HP:0009836)1.83308934
92Exotropia (HP:0000577)1.79148113
93Abnormality of the antihelix (HP:0009738)1.79145836
94Microretrognathia (HP:0000308)1.79050227
95Amblyopia (HP:0000646)1.78405394
96Drooling (HP:0002307)1.77904435
97Absent thumb (HP:0009777)1.76594827
98Vaginal atresia (HP:0000148)1.75300307
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75153675
100Hypoplasia of the brainstem (HP:0002365)1.75153675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK1B3.65453831
2EPHB23.33156060
3MAPK132.82903861
4PIM22.73120368
5BMPR1B2.62100475
6WNK42.51620170
7PTK62.49675829
8TNIK2.46839916
9CDK192.41433014
10NTRK22.36281777
11WNK32.29160254
12DYRK22.27058161
13CAMKK22.16382427
14STK391.95751320
15MARK11.85403402
16FRK1.77229430
17CASK1.70254206
18MARK21.55372989
19PRKCG1.50974105
20STK111.49837560
21BCKDK1.49088302
22NTRK31.48349168
23ADRBK21.46636041
24GRK11.46218859
25CAMK1D1.37598003
26CSNK1G21.35612331
27MAP3K111.35006703
28PAK31.34725130
29NUAK11.30363108
30TGFBR11.27906611
31OXSR11.24887853
32PINK11.22360409
33CDK81.16854547
34BCR1.14846369
35NME11.13913676
36PHKG11.13458150
37PHKG21.13458150
38TYRO31.08945648
39MAP3K41.06922734
40WNK11.05896465
41PRKCZ1.03396737
42DAPK30.97245479
43MAP2K70.97121104
44ZAK0.96170853
45SIK20.95666455
46PRKCH0.91927483
47CSNK1G10.87194867
48PAK60.85651094
49CSNK1G30.85353889
50CAMK10.83098922
51LRRK20.82177419
52SGK2230.81461790
53SGK4940.81461790
54TIE10.81457383
55EPHA40.81155073
56CDK140.78301734
57CAMK2D0.76800229
58CSNK1A1L0.76274259
59CAMKK10.73400952
60CAMK1G0.73282133
61CHEK20.68935831
62SGK10.66218507
63CAMK2B0.65694649
64STK160.65583558
65DYRK1A0.65335383
66ADRBK10.64433012
67LIMK10.63070395
68DMPK0.60348623
69NTRK10.59268263
70PKN10.59236132
71SGK20.59225145
72MKNK20.58476189
73MAP2K40.57300535
74CAMK40.56598720
75RPS6KA60.54715218
76PDK20.54369914
77PRKCQ0.52721791
78MAP3K120.50442682
79CAMK2A0.50351068
80ABL20.50329933
81CDK11A0.47514503
82PRKAA10.47185187
83SIK10.46982574
84PRKACA0.45537411
85TXK0.45407810
86MARK30.45233188
87PRKCI0.44553771
88CDK150.44497975
89MINK10.44481264
90CAMK2G0.42082859
91CDK50.40367117
92EIF2AK20.40108702
93PIM10.39650282
94CDK180.39130257
95RPS6KC10.39053193
96RPS6KL10.39053193
97PLK20.38748953
98VRK20.37248713
99PRKCE0.36326615
100CSNK1E0.35834968

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.20903161
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90355839
3Butanoate metabolism_Homo sapiens_hsa006502.40206432
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37862404
5Oxidative phosphorylation_Homo sapiens_hsa001902.37747375
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26011529
7Sulfur relay system_Homo sapiens_hsa041222.22929650
8Linoleic acid metabolism_Homo sapiens_hsa005912.21900988
9Nicotine addiction_Homo sapiens_hsa050332.14358440
10Cardiac muscle contraction_Homo sapiens_hsa042602.09123395
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02495689
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83020292
13Parkinsons disease_Homo sapiens_hsa050121.81526873
14RNA degradation_Homo sapiens_hsa030181.80230904
15RNA polymerase_Homo sapiens_hsa030201.78148659
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73103478
17Steroid biosynthesis_Homo sapiens_hsa001001.69095492
18Huntingtons disease_Homo sapiens_hsa050161.66790929
19Dorso-ventral axis formation_Homo sapiens_hsa043201.58948790
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.51379454
21Fatty acid elongation_Homo sapiens_hsa000621.48744209
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.45469212
23Basal transcription factors_Homo sapiens_hsa030221.45029876
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38347314
25Insulin secretion_Homo sapiens_hsa049111.33525724
26Glutamatergic synapse_Homo sapiens_hsa047241.30356331
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28664908
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28571874
29Homologous recombination_Homo sapiens_hsa034401.26794149
30Melanoma_Homo sapiens_hsa052181.22898918
31Alzheimers disease_Homo sapiens_hsa050101.20162812
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17887061
33Regulation of autophagy_Homo sapiens_hsa041401.10382121
34Peroxisome_Homo sapiens_hsa041461.09269676
35Basal cell carcinoma_Homo sapiens_hsa052171.08253980
36Notch signaling pathway_Homo sapiens_hsa043301.07792176
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.06762295
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06200471
39Axon guidance_Homo sapiens_hsa043601.05082672
40Fanconi anemia pathway_Homo sapiens_hsa034601.04362560
41Caffeine metabolism_Homo sapiens_hsa002321.03817341
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01951465
43Ether lipid metabolism_Homo sapiens_hsa005651.00797939
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99888714
45Taste transduction_Homo sapiens_hsa047420.96554571
46Dopaminergic synapse_Homo sapiens_hsa047280.95771328
47Chemical carcinogenesis_Homo sapiens_hsa052040.88706525
48Protein export_Homo sapiens_hsa030600.88384332
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87477758
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87413228
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86262648
52Hippo signaling pathway_Homo sapiens_hsa043900.84885260
53Tryptophan metabolism_Homo sapiens_hsa003800.84310852
54Long-term depression_Homo sapiens_hsa047300.83092604
55Type II diabetes mellitus_Homo sapiens_hsa049300.79915233
56Pyrimidine metabolism_Homo sapiens_hsa002400.79106207
57Ovarian steroidogenesis_Homo sapiens_hsa049130.76703361
58Phototransduction_Homo sapiens_hsa047440.75922818
59Hedgehog signaling pathway_Homo sapiens_hsa043400.75097580
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74679767
61Morphine addiction_Homo sapiens_hsa050320.74645977
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73997429
63Nitrogen metabolism_Homo sapiens_hsa009100.73958990
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73713379
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73193634
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73010757
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72218784
68ABC transporters_Homo sapiens_hsa020100.70969558
69Oxytocin signaling pathway_Homo sapiens_hsa049210.70128144
70Calcium signaling pathway_Homo sapiens_hsa040200.68578676
71Circadian entrainment_Homo sapiens_hsa047130.68463559
72Metabolic pathways_Homo sapiens_hsa011000.64647026
73Fat digestion and absorption_Homo sapiens_hsa049750.63667753
74Serotonergic synapse_Homo sapiens_hsa047260.63597564
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61576188
76Glycerolipid metabolism_Homo sapiens_hsa005610.61325962
77Vitamin B6 metabolism_Homo sapiens_hsa007500.60354402
78Cholinergic synapse_Homo sapiens_hsa047250.59496316
79Mismatch repair_Homo sapiens_hsa034300.59143906
80Ras signaling pathway_Homo sapiens_hsa040140.58618044
81MAPK signaling pathway_Homo sapiens_hsa040100.57572126
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56827875
83Fatty acid degradation_Homo sapiens_hsa000710.52647981
84Olfactory transduction_Homo sapiens_hsa047400.52231585
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.51940791
86beta-Alanine metabolism_Homo sapiens_hsa004100.48835505
87Asthma_Homo sapiens_hsa053100.48829645
88Synaptic vesicle cycle_Homo sapiens_hsa047210.47864737
89Propanoate metabolism_Homo sapiens_hsa006400.46398040
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46230595
91Wnt signaling pathway_Homo sapiens_hsa043100.45438929
92Purine metabolism_Homo sapiens_hsa002300.44783004
93Arachidonic acid metabolism_Homo sapiens_hsa005900.44705560
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43400499
95Retinol metabolism_Homo sapiens_hsa008300.42765017
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41330634
97One carbon pool by folate_Homo sapiens_hsa006700.40583967
98GnRH signaling pathway_Homo sapiens_hsa049120.40526079
99Mineral absorption_Homo sapiens_hsa049780.39836106
100Non-homologous end-joining_Homo sapiens_hsa034500.39683630

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