ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.36483131
2	translational termination (GO:0006415)	8.97311233
3	ribosomal small subunit biogenesis (GO:0042274)	8.76040539
4	ribosomal small subunit assembly (GO:0000028)	8.68988696
5	maturation of SSU-rRNA (GO:0030490)	8.61620241
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.60942648
7	cotranslational protein targeting to membrane (GO:0006613)	7.48134102
8	protein targeting to ER (GO:0045047)	7.47409129
9	translational elongation (GO:0006414)	7.46482551
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.16599602
11	protein localization to endoplasmic reticulum (GO:0070972)	7.00749311
12	cellular protein complex disassembly (GO:0043624)	6.82990592
13	viral life cycle (GO:0019058)	6.81029982
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.65073686
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.93482403
16	ATP synthesis coupled proton transport (GO:0015986)	5.93482403
17	translational initiation (GO:0006413)	5.86994169
18	protein complex disassembly (GO:0043241)	5.79142629
19	macromolecular complex disassembly (GO:0032984)	5.48615972
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.46608153
21	protein targeting to membrane (GO:0006612)	5.22899818
22	ribosomal large subunit biogenesis (GO:0042273)	5.21902713
23	chaperone-mediated protein transport (GO:0072321)	4.99862392
24	behavioral response to nicotine (GO:0035095)	4.81773386
25	substrate-independent telencephalic tangential migration (GO:0021826)	4.74936013
26	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.74936013
27	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.67018144
28	translation (GO:0006412)	4.58716086
29	protein complex biogenesis (GO:0070271)	4.41893374
30	mRNA catabolic process (GO:0006402)	4.41545576
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.33628655
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.30722957
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.30722957
34	NADH dehydrogenase complex assembly (GO:0010257)	4.30722957
35	respiratory electron transport chain (GO:0022904)	4.05839627
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.05192860
37	electron transport chain (GO:0022900)	4.00595753
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.95960042
39	RNA catabolic process (GO:0006401)	3.90517919
40	tongue development (GO:0043586)	3.85416437
41	cellular component biogenesis (GO:0044085)	3.78865249
42	protein neddylation (GO:0045116)	3.77929539
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.75358748
44	GTP biosynthetic process (GO:0006183)	3.71981241
45	cell proliferation in forebrain (GO:0021846)	3.57465106
46	nonmotile primary cilium assembly (GO:0035058)	3.57049059
47	establishment of protein localization to membrane (GO:0090150)	3.51686348
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.49515586
49	ATP biosynthetic process (GO:0006754)	3.42421168
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.40176579
51	protein targeting (GO:0006605)	3.28291695
52	pyrimidine nucleobase catabolic process (GO:0006208)	3.26857318
53	UTP biosynthetic process (GO:0006228)	3.24098734
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14692845
55	hydrogen ion transmembrane transport (GO:1902600)	3.13853325
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.08850032
57	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.04455782
58	establishment of protein localization to organelle (GO:0072594)	3.01375779
59	somite development (GO:0061053)	2.96557035
60	UTP metabolic process (GO:0046051)	2.88749466
61	regulation of isotype switching to IgG isotypes (GO:0048302)	2.87814250
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84735259
63	DNA deamination (GO:0045006)	2.84440653
64	protein localization to membrane (GO:0072657)	2.83506887
65	epithelial cilium movement (GO:0003351)	2.77823542
66	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.76235225
67	rRNA processing (GO:0006364)	2.76174804
68	proton transport (GO:0015992)	2.74213310
69	neuron fate determination (GO:0048664)	2.73075734
70	protein polyglutamylation (GO:0018095)	2.73071248
71	positive regulation of respiratory burst (GO:0060267)	2.71982837
72	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.71078132
73	rRNA metabolic process (GO:0016072)	2.69057993
74	regulation of cilium movement (GO:0003352)	2.67599605
75	hydrogen transport (GO:0006818)	2.66805226
76	ubiquinone biosynthetic process (GO:0006744)	2.66636569
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.61295475
78	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.61295475
79	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59581673
80	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.59397923
81	termination of RNA polymerase III transcription (GO:0006386)	2.58430686
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58430686
83	nucleobase catabolic process (GO:0046113)	2.57422437
84	synaptic transmission, cholinergic (GO:0007271)	2.54779620
85	hypothalamus development (GO:0021854)	2.53710903
86	CTP metabolic process (GO:0046036)	2.52235928
87	CTP biosynthetic process (GO:0006241)	2.52235928
88	regulation of cellular respiration (GO:0043457)	2.48913095
89	nucleoside triphosphate biosynthetic process (GO:0009142)	2.48601297
90	negative regulation of appetite (GO:0032099)	2.48345330
91	negative regulation of response to food (GO:0032096)	2.48345330
92	myoblast migration (GO:0051451)	2.47963044
93	cardiovascular system development (GO:0072358)	2.46268206
94	ubiquinone metabolic process (GO:0006743)	2.43500913
95	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.39854387
96	dentate gyrus development (GO:0021542)	2.39528498
97	protein peptidyl-prolyl isomerization (GO:0000413)	2.39169629
98	spinal cord association neuron differentiation (GO:0021527)	2.38841300
99	interferon-gamma production (GO:0032609)	2.38745357
100	axonal fasciculation (GO:0007413)	2.32733928

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.26822645
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.78656508
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.41561199
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17752980
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99226524
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.88786231
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.86127052
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73762283
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.49712026
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.46173668
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.27821241
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.04255239
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.94604787
14	VDR_22108803_ChIP-Seq_LS180_Human	1.87719366
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.80958285
16	TTF2_22483619_ChIP-Seq_HELA_Human	1.76909665
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.76432504
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75496306
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70966100
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.66559745
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.65342605
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64020229
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.63455131
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.62953364
25	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.62166959
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59553410
27	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.58905284
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54769954
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54712203
30	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.50435024
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49083462
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48827921
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48345519
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.47119228
35	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46778718
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.45357919
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42544356
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42507473
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42036028
40	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.41901339
41	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.41522735
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.41111898
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39531383
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35497683
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32897878
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.29268341
47	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.29238592
48	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.27485584
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.26725706
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22919320
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22004110
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21407651
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19635782
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19573254
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.19428704
56	ERA_21632823_ChIP-Seq_H3396_Human	1.18381982
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16190018
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14978930
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14668023
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.14463407
61	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14352499
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14038172
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.13972500
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11765881
65	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11268603
66	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10699451
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08312553
68	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06180887
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.06159349
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06093396
71	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04428709
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03283773
73	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02911305
74	NCOR_22424771_ChIP-Seq_293T_Human	1.02241912
75	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.02126849
76	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02044536
77	EWS_26573619_Chip-Seq_HEK293_Human	1.00875973
78	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97493023
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96694111
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96563802
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96503308
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96196419
83	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95953091
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95699725
85	CIITA_25753668_ChIP-Seq_RAJI_Human	0.94925738
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94901693
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93647537
88	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.93069770
89	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93017610
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91853790
91	CTCF_27219007_Chip-Seq_Bcells_Human	0.90829438
92	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.89847796
93	BCL6_27268052_Chip-Seq_Bcells_Human	0.88814019
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.88278014
95	FUS_26573619_Chip-Seq_HEK293_Human	0.86042688
96	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.85823846
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.85123287
98	AR_20517297_ChIP-Seq_VCAP_Human	0.84891900
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84700530
100	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.84255118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.91397442
2	MP0006292_abnormal_olfactory_placode	5.20245418
3	MP0003787_abnormal_imprinting	3.57691180
4	MP0008789_abnormal_olfactory_epithelium	2.86999362
5	MP0003122_maternal_imprinting	2.60123812
6	MP0008877_abnormal_DNA_methylation	2.50061964
7	MP0004142_abnormal_muscle_tone	2.44128480
8	MP0005394_taste/olfaction_phenotype	2.30435313
9	MP0005499_abnormal_olfactory_system	2.30435313
10	MP0002163_abnormal_gland_morphology	2.26337816
11	MP0002638_abnormal_pupillary_reflex	2.23697286
12	MP0003123_paternal_imprinting	2.12255124
13	MP0003646_muscle_fatigue	2.10215179
14	MP0002653_abnormal_ependyma_morphology	2.08097842
15	MP0003121_genomic_imprinting	2.05954493
16	MP0001984_abnormal_olfaction	1.87509405
17	MP0001529_abnormal_vocalization	1.84352434
18	MP0001293_anophthalmia	1.79266246
19	MP0008872_abnormal_physiological_respon	1.73913129
20	MP0001485_abnormal_pinna_reflex	1.70267966
21	MP0000778_abnormal_nervous_system	1.63229676
22	MP0003878_abnormal_ear_physiology	1.62559182
23	MP0005377_hearing/vestibular/ear_phenot	1.62559182
24	MP0006276_abnormal_autonomic_nervous	1.62376340
25	MP0004147_increased_porphyrin_level	1.56533560
26	MP0004885_abnormal_endolymph	1.55128943
27	MP0003880_abnormal_central_pattern	1.54733236
28	MP0000631_abnormal_neuroendocrine_gland	1.44162911
29	MP0001986_abnormal_taste_sensitivity	1.40076673
30	MP0008875_abnormal_xenobiotic_pharmacok	1.39535827
31	MP0004145_abnormal_muscle_electrophysio	1.37100745
32	MP0002102_abnormal_ear_morphology	1.36727893
33	MP0005551_abnormal_eye_electrophysiolog	1.34227697
34	MP0003136_yellow_coat_color	1.33155740
35	MP0002938_white_spotting	1.32390099
36	MP0000566_synostosis	1.30689883
37	MP0001905_abnormal_dopamine_level	1.30671827
38	MP0000049_abnormal_middle_ear	1.29486411
39	MP0002234_abnormal_pharynx_morphology	1.28549801
40	MP0002272_abnormal_nervous_system	1.27210719
41	MP0003011_delayed_dark_adaptation	1.22832530
42	MP0005423_abnormal_somatic_nervous	1.21437253
43	MP0001968_abnormal_touch/_nociception	1.20881419
44	MP0001502_abnormal_circadian_rhythm	1.20619623
45	MP0002160_abnormal_reproductive_system	1.20057548
46	MP0005084_abnormal_gallbladder_morpholo	1.18289132
47	MP0005671_abnormal_response_to	1.18207752
48	MP0005389_reproductive_system_phenotype	1.17490616
49	MP0001919_abnormal_reproductive_system	1.14277288
50	MP0002557_abnormal_social/conspecific_i	1.13682442
51	MP0001440_abnormal_grooming_behavior	1.13004776
52	MP0001970_abnormal_pain_threshold	1.12144271
53	MP0006072_abnormal_retinal_apoptosis	1.11734144
54	MP0005379_endocrine/exocrine_gland_phen	1.11718012
55	MP0004742_abnormal_vestibular_system	1.10593395
56	MP0009745_abnormal_behavioral_response	1.09962679
57	MP0005195_abnormal_posterior_eye	1.09919291
58	MP0002184_abnormal_innervation	1.04391532
59	MP0000026_abnormal_inner_ear	1.04138587
60	MP0000955_abnormal_spinal_cord	1.03650824
61	MP0002736_abnormal_nociception_after	1.02918479
62	MP0002095_abnormal_skin_pigmentation	1.02141371
63	MP0001873_stomach_inflammation	1.01595113
64	MP0003186_abnormal_redox_activity	1.00308841
65	MP0002752_abnormal_somatic_nervous	0.99366240
66	MP0004133_heterotaxia	0.98628145
67	MP0003938_abnormal_ear_development	0.97673144
68	MP0000372_irregular_coat_pigmentation	0.97252905
69	MP0002572_abnormal_emotion/affect_behav	0.97175662
70	MP0009053_abnormal_anal_canal	0.96846959
71	MP0001663_abnormal_digestive_system	0.91011490
72	MP0002063_abnormal_learning/memory/cond	0.90875173
73	MP0001348_abnormal_lacrimal_gland	0.90553297
74	MP0002837_dystrophic_cardiac_calcinosis	0.89721339
75	MP0002233_abnormal_nose_morphology	0.88243213
76	MP0005646_abnormal_pituitary_gland	0.87031174
77	MP0003879_abnormal_hair_cell	0.86438228
78	MP0008775_abnormal_heart_ventricle	0.85747157
79	MP0002733_abnormal_thermal_nociception	0.83567499
80	MP0003635_abnormal_synaptic_transmissio	0.83068795
81	MP0001486_abnormal_startle_reflex	0.82702295
82	MP0001286_abnormal_eye_development	0.82527451
83	MP0001963_abnormal_hearing_physiology	0.82275441
84	MP0001835_abnormal_antigen_presentation	0.82101698
85	MP0010030_abnormal_orbit_morphology	0.81357016
86	MP0003942_abnormal_urinary_system	0.78757597
87	MP0002277_abnormal_respiratory_mucosa	0.77473766
88	MP0005253_abnormal_eye_physiology	0.76955803
89	MP0002882_abnormal_neuron_morphology	0.75897831
90	MP0002067_abnormal_sensory_capabilities	0.73728949
91	MP0002928_abnormal_bile_duct	0.73346930
92	MP0008058_abnormal_DNA_repair	0.72256223
93	MP0002210_abnormal_sex_determination	0.71621365
94	MP0003567_abnormal_fetal_cardiomyocyte	0.71189263
95	MP0005645_abnormal_hypothalamus_physiol	0.70492306
96	MP0002064_seizures	0.68297740
97	MP0002876_abnormal_thyroid_physiology	0.66461647
98	MP0005391_vision/eye_phenotype	0.64695916
99	MP0009046_muscle_twitch	0.64565157
100	MP0005381_digestive/alimentary_phenotyp	0.63516470

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.89092205
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.48532346
3	Macrocytic anemia (HP:0001972)	4.46172480
4	Acute necrotizing encephalopathy (HP:0006965)	4.40393463
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.94458615
6	Mitochondrial inheritance (HP:0001427)	3.86700175
7	Abnormal number of erythroid precursors (HP:0012131)	3.83560341
8	Acute encephalopathy (HP:0006846)	3.79564210
9	Molar tooth sign on MRI (HP:0002419)	3.75192319
10	Abnormality of midbrain morphology (HP:0002418)	3.75192319
11	Septo-optic dysplasia (HP:0100842)	3.72965112
12	Pallor (HP:0000980)	3.63255305
13	Progressive macrocephaly (HP:0004481)	3.46360233
14	Increased CSF lactate (HP:0002490)	3.43353650
15	Stenosis of the external auditory canal (HP:0000402)	3.33660258
16	Hepatocellular necrosis (HP:0001404)	3.27514604
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.26190970
18	Absent thumb (HP:0009777)	3.20979724
19	Colon cancer (HP:0003003)	3.18649163
20	Increased hepatocellular lipid droplets (HP:0006565)	3.04506205
21	Pancreatic fibrosis (HP:0100732)	3.04458013
22	3-Methylglutaconic aciduria (HP:0003535)	3.00745398
23	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.94952914
24	Medial flaring of the eyebrow (HP:0010747)	2.88560037
25	Lipid accumulation in hepatocytes (HP:0006561)	2.80986569
26	Rib fusion (HP:0000902)	2.80801003
27	Pancreatic cysts (HP:0001737)	2.77789261
28	Hepatic necrosis (HP:0002605)	2.77343321
29	Cerebral edema (HP:0002181)	2.75331821
30	Nephronophthisis (HP:0000090)	2.65137456
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.64740270
32	Asplenia (HP:0001746)	2.60449025
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.55098602
34	Renal Fanconi syndrome (HP:0001994)	2.51723846
35	Increased intramyocellular lipid droplets (HP:0012240)	2.50270416
36	Gait imbalance (HP:0002141)	2.50063687
37	Optic disc pallor (HP:0000543)	2.49009570
38	True hermaphroditism (HP:0010459)	2.46102409
39	Abnormality of DNA repair (HP:0003254)	2.45338272
40	Hypoplasia of the radius (HP:0002984)	2.44074326
41	Partial duplication of thumb phalanx (HP:0009944)	2.42498392
42	Abolished electroretinogram (ERG) (HP:0000550)	2.39220483
43	Abnormal hemoglobin (HP:0011902)	2.38465014
44	Congenital primary aphakia (HP:0007707)	2.31923961
45	Myokymia (HP:0002411)	2.31887542
46	Depressed nasal ridge (HP:0000457)	2.29229857
47	Absent septum pellucidum (HP:0001331)	2.29164254
48	Type II lissencephaly (HP:0007260)	2.29142331
49	Hyperglycinemia (HP:0002154)	2.23728127
50	Hypoplasia of the ulna (HP:0003022)	2.23005568
51	Increased serum lactate (HP:0002151)	2.22715067
52	11 pairs of ribs (HP:0000878)	2.21932342
53	Forearm undergrowth (HP:0009821)	2.21392242
54	Chorioretinal atrophy (HP:0000533)	2.19756260
55	Pendular nystagmus (HP:0012043)	2.18007288
56	Adrenal hypoplasia (HP:0000835)	2.16943622
57	Exertional dyspnea (HP:0002875)	2.12472769
58	Anencephaly (HP:0002323)	2.10698581
59	Abnormality of the renal medulla (HP:0100957)	2.07816439
60	Absent/shortened dynein arms (HP:0200106)	2.07117179
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.07117179
62	Oligodactyly (HP:0012165)	2.06654118
63	Abnormality of the labia minora (HP:0012880)	2.06370927
64	Increased muscle lipid content (HP:0009058)	2.06093293
65	Lactic acidosis (HP:0003128)	2.04345726
66	Optic nerve hypoplasia (HP:0000609)	2.03298728
67	Nephrogenic diabetes insipidus (HP:0009806)	2.02702123
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02665198
69	Sclerocornea (HP:0000647)	2.02317050
70	Oligodactyly (hands) (HP:0001180)	2.00583040
71	Growth hormone deficiency (HP:0000824)	1.99984818
72	Chronic hepatic failure (HP:0100626)	1.97904744
73	Congenital stationary night blindness (HP:0007642)	1.97650984
74	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.91538318
75	Abnormality of renal resorption (HP:0011038)	1.90740585
76	Respiratory failure (HP:0002878)	1.90495531
77	Agitation (HP:0000713)	1.89696952
78	Vaginal atresia (HP:0000148)	1.89208550
79	Partial duplication of the phalanx of hand (HP:0009999)	1.89039050
80	Postaxial foot polydactyly (HP:0001830)	1.88098078
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88044862
82	Supernumerary spleens (HP:0009799)	1.87735497
83	Cystic liver disease (HP:0006706)	1.87243519
84	Horseshoe kidney (HP:0000085)	1.86419722
85	Polyphagia (HP:0002591)	1.86327005
86	Maternal diabetes (HP:0009800)	1.85321986
87	Abnormal ciliary motility (HP:0012262)	1.83544720
88	Leukodystrophy (HP:0002415)	1.81457450
89	Exercise intolerance (HP:0003546)	1.81327051
90	Triphalangeal thumb (HP:0001199)	1.81174926
91	Tubular atrophy (HP:0000092)	1.79035089
92	Genital tract atresia (HP:0001827)	1.76948972
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76383962
94	Ectopic kidney (HP:0000086)	1.76207905
95	Anophthalmia (HP:0000528)	1.75790014
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.74557043
97	Constricted visual fields (HP:0001133)	1.74004686
98	Respiratory difficulties (HP:0002880)	1.73435168
99	Abnormality of the septum pellucidum (HP:0007375)	1.69700225
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.69616721

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	2.97171286
2	WNK4	2.79416266
3	TLK1	2.48177120
4	DYRK2	2.43901282
5	ADRBK2	2.43133033
6	CASK	2.36903362
7	PINK1	2.33078782
8	EPHB2	2.31368062
9	CAMKK2	2.30345543
10	GRK1	2.13492913
11	MAP4K2	2.05553535
12	LRRK2	2.00821896
13	ZAK	1.96721508
14	PIK3CA	1.94895427
15	MAP3K11	1.90216392
16	MAP3K12	1.81990168
17	VRK2	1.67843963
18	CAMK1D	1.66150471
19	CAMK1	1.64095340
20	TXK	1.61756469
21	STK16	1.51859117
22	BCKDK	1.50726370
23	PRKD3	1.46660794
24	TYRO3	1.46391446
25	MAP2K7	1.40262706
26	PRKCG	1.33844532
27	WNK3	1.33512866
28	EPHA4	1.30110070
29	VRK1	1.28898964
30	PLK4	1.23888644
31	NEK1	1.17785579
32	CAMKK1	1.17180212
33	NME1	1.12764941
34	ARAF	1.09783335
35	MUSK	1.09277287
36	FRK	1.04124852
37	DAPK3	1.03897565
38	BRAF	1.00781310
39	STK11	0.99309502
40	STK39	0.98614962
41	NME2	0.97304794
42	MAPK13	0.97140070
43	PRKCH	0.95503186
44	NTRK2	0.94265412
45	CAMK1G	0.94177213
46	PDK2	0.93972472
47	NUAK1	0.91561449
48	OXSR1	0.90514928
49	TIE1	0.90452547
50	MAP3K4	0.88497518
51	WNK1	0.87424149
52	MAP2K6	0.86335173
53	ADRBK1	0.83748972
54	PRKCQ	0.79574122
55	MARK3	0.79396948
56	TNIK	0.79148749
57	BTK	0.78709744
58	MKNK2	0.78158875
59	RPS6KA6	0.76854120
60	CSNK2A2	0.76434019
61	AURKA	0.75787003
62	MARK1	0.74213577
63	SRPK1	0.73224258
64	PASK	0.72710434
65	TRIM28	0.71807903
66	AURKB	0.69915730
67	PHKG1	0.66988789
68	PHKG2	0.66988789
69	CDK8	0.66785439
70	DYRK1B	0.66748175
71	TEC	0.65242287
72	PRKACA	0.64820574
73	CSNK1E	0.63874164
74	PRKCI	0.61814888
75	ITK	0.60925682
76	CHEK2	0.60565780
77	RPS6KC1	0.60467694
78	RPS6KL1	0.60467694
79	DAPK2	0.59610297
80	BMPR1B	0.59596550
81	INSRR	0.58706208
82	MINK1	0.57854849
83	MAPK15	0.55776543
84	ABL2	0.55564873
85	IKBKB	0.55160638
86	PRKCD	0.53902715
87	PRKCZ	0.53831844
88	PIM1	0.52227726
89	CAMK4	0.50539222
90	TAF1	0.49943564
91	PLK1	0.48307851
92	PIM2	0.46671051
93	PAK3	0.46449881
94	CDC7	0.46189284
95	CSNK2A1	0.45972970
96	RPS6KA5	0.43839139
97	MAP2K4	0.43518962
98	CSNK1A1	0.41097788
99	OBSCN	0.41077865
100	CSNK1G2	0.39269198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.56452590
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.63801642
3	Parkinsons disease_Homo sapiens_hsa05012	3.90135129
4	Huntingtons disease_Homo sapiens_hsa05016	2.80974418
5	Alzheimers disease_Homo sapiens_hsa05010	2.69563269
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.68438872
7	Proteasome_Homo sapiens_hsa03050	2.46594252
8	RNA polymerase_Homo sapiens_hsa03020	2.44942335
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.44800412
10	Asthma_Homo sapiens_hsa05310	2.18326397
11	Protein export_Homo sapiens_hsa03060	2.17669821
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08458962
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06829282
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74091372
15	Homologous recombination_Homo sapiens_hsa03440	1.56937397
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56378216
17	RNA degradation_Homo sapiens_hsa03018	1.44467587
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43735688
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41028443
20	Allograft rejection_Homo sapiens_hsa05330	1.39626990
21	Basal transcription factors_Homo sapiens_hsa03022	1.30138127
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20543303
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19529338
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16694811
25	Phototransduction_Homo sapiens_hsa04744	1.12343575
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.10781263
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10484084
28	One carbon pool by folate_Homo sapiens_hsa00670	1.09894125
29	Butanoate metabolism_Homo sapiens_hsa00650	1.04586324
30	Nicotine addiction_Homo sapiens_hsa05033	0.98951324
31	Regulation of autophagy_Homo sapiens_hsa04140	0.98515760
32	Basal cell carcinoma_Homo sapiens_hsa05217	0.96939214
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95717111
34	Sulfur relay system_Homo sapiens_hsa04122	0.92948913
35	Caffeine metabolism_Homo sapiens_hsa00232	0.92236314
36	Graft-versus-host disease_Homo sapiens_hsa05332	0.89899118
37	Steroid biosynthesis_Homo sapiens_hsa00100	0.85584982
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.85219921
39	Propanoate metabolism_Homo sapiens_hsa00640	0.84941685
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.84746432
41	Peroxisome_Homo sapiens_hsa04146	0.82101954
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78025654
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75694062
44	Morphine addiction_Homo sapiens_hsa05032	0.72360689
45	Mismatch repair_Homo sapiens_hsa03430	0.69917305
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69413073
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69190699
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66979824
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.64782632
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62644501
51	Base excision repair_Homo sapiens_hsa03410	0.62207171
52	Metabolic pathways_Homo sapiens_hsa01100	0.60541009
53	Olfactory transduction_Homo sapiens_hsa04740	0.59795338
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59381703
55	Spliceosome_Homo sapiens_hsa03040	0.57757436
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56840170
57	Purine metabolism_Homo sapiens_hsa00230	0.56749780
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54258267
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.54111125
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53802341
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52782538
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52777876
63	Folate biosynthesis_Homo sapiens_hsa00790	0.51564487
64	Retinol metabolism_Homo sapiens_hsa00830	0.51181539
65	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49287316
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.48584283
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.45959163
68	Fatty acid degradation_Homo sapiens_hsa00071	0.45113228
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43952738
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43363771
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43097982
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42164652
73	RNA transport_Homo sapiens_hsa03013	0.41702122
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41487402
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.40236350
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39890766
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39714260
78	GABAergic synapse_Homo sapiens_hsa04727	0.39384298
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39024642
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38327875
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36018089
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34718808
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32883225
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32815779
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31584090
86	Serotonergic synapse_Homo sapiens_hsa04726	0.31563433
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31465553
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30651828
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29746250
90	Taste transduction_Homo sapiens_hsa04742	0.28453299
91	Axon guidance_Homo sapiens_hsa04360	0.27443027
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.27338462
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26907174
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.26790162
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25827597
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.25111218
97	Alcoholism_Homo sapiens_hsa05034	0.23547733
98	DNA replication_Homo sapiens_hsa03030	0.23184696
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21647801
100	Insulin secretion_Homo sapiens_hsa04911	0.20940447

RPS15AP24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »