ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.38010312
2	viral transcription (GO:0019083)	8.06937549
3	maturation of SSU-rRNA (GO:0030490)	7.68460970
4	translational termination (GO:0006415)	7.64767262
5	behavioral response to nicotine (GO:0035095)	7.09779953
6	ribosomal small subunit assembly (GO:0000028)	6.49048809
7	viral life cycle (GO:0019058)	6.18225297
8	translational elongation (GO:0006414)	6.03996889
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.99842427
10	protein targeting to ER (GO:0045047)	5.94643791
11	cotranslational protein targeting to membrane (GO:0006613)	5.84881811
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.82641296
13	cellular protein complex disassembly (GO:0043624)	5.80597174
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.52695037
15	cell proliferation in forebrain (GO:0021846)	5.50639777
16	protein localization to endoplasmic reticulum (GO:0070972)	5.47879735
17	respiratory tube development (GO:0030323)	5.31689484
18	protein complex disassembly (GO:0043241)	5.07070986
19	metanephric nephron tubule development (GO:0072234)	5.06839164
20	metanephric tubule development (GO:0072170)	5.06839164
21	lens fiber cell development (GO:0070307)	5.01497946
22	collecting duct development (GO:0072044)	4.85919157
23	lung-associated mesenchyme development (GO:0060484)	4.81049284
24	macromolecular complex disassembly (GO:0032984)	4.76652758
25	cell wall macromolecule catabolic process (GO:0016998)	4.50487441
26	kidney morphogenesis (GO:0060993)	4.48876752
27	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.48637117
28	substrate-independent telencephalic tangential migration (GO:0021826)	4.48637117
29	negative regulation of organelle assembly (GO:1902116)	4.47163096
30	metanephric nephron epithelium development (GO:0072243)	4.46811250
31	lung epithelium development (GO:0060428)	4.42705493
32	translational initiation (GO:0006413)	4.38516589
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.34903892
34	pyrimidine nucleotide catabolic process (GO:0006244)	4.24084281
35	protein targeting to membrane (GO:0006612)	4.20860702
36	nonmotile primary cilium assembly (GO:0035058)	4.18790123
37	metanephric epithelium development (GO:0072207)	4.09551836
38	intraciliary transport (GO:0042073)	4.01050451
39	pyrimidine nucleobase catabolic process (GO:0006208)	3.94296924
40	lung morphogenesis (GO:0060425)	3.82880254
41	hypothalamus development (GO:0021854)	3.82579499
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.81312159
43	somite development (GO:0061053)	3.74911299
44	axon ensheathment in central nervous system (GO:0032291)	3.72361716
45	central nervous system myelination (GO:0022010)	3.72361716
46	cell wall macromolecule metabolic process (GO:0044036)	3.71879069
47	tongue development (GO:0043586)	3.69005850
48	cardiovascular system development (GO:0072358)	3.67731504
49	mRNA catabolic process (GO:0006402)	3.66733117
50	cell migration in hindbrain (GO:0021535)	3.66597367
51	cartilage morphogenesis (GO:0060536)	3.54266186
52	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.54225118
53	anatomical structure regression (GO:0060033)	3.53547998
54	nephron tubule development (GO:0072080)	3.51916186
55	chaperone-mediated protein transport (GO:0072321)	3.50126500
56	retinal ganglion cell axon guidance (GO:0031290)	3.48242341
57	neuron fate determination (GO:0048664)	3.42878978
58	positive regulation of protein homooligomerization (GO:0032464)	3.31317942
59	protein neddylation (GO:0045116)	3.29243811
60	RNA catabolic process (GO:0006401)	3.22627512
61	pattern specification involved in kidney development (GO:0061004)	3.21344375
62	renal tubule development (GO:0061326)	3.13536481
63	water-soluble vitamin biosynthetic process (GO:0042364)	3.13369776
64	negative regulation of appetite (GO:0032099)	3.10804392
65	negative regulation of response to food (GO:0032096)	3.10804392
66	spinal cord association neuron differentiation (GO:0021527)	3.08228288
67	urogenital system development (GO:0001655)	3.07546373
68	segment specification (GO:0007379)	3.05135786
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04918489
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04918489
71	NADH dehydrogenase complex assembly (GO:0010257)	3.04918489
72	parturition (GO:0007567)	3.03028356
73	positive regulation of T cell apoptotic process (GO:0070234)	2.99951904
74	nucleobase catabolic process (GO:0046113)	2.95134377
75	body morphogenesis (GO:0010171)	2.94670789
76	embryonic body morphogenesis (GO:0010172)	2.93248050
77	translation (GO:0006412)	2.92634022
78	ribonucleoprotein complex biogenesis (GO:0022613)	2.91664763
79	spinal cord development (GO:0021510)	2.91627688
80	myoblast migration (GO:0051451)	2.91095494
81	establishment of protein localization to membrane (GO:0090150)	2.90862804
82	ribosomal large subunit biogenesis (GO:0042273)	2.86805079
83	left/right pattern formation (GO:0060972)	2.83479432
84	olfactory bulb development (GO:0021772)	2.78130274
85	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.77475201
86	ubiquinone biosynthetic process (GO:0006744)	2.74486889
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72073977
88	head development (GO:0060322)	2.71565940
89	forebrain morphogenesis (GO:0048853)	2.70529885
90	cellular component biogenesis (GO:0044085)	2.70142481
91	forebrain neuron differentiation (GO:0021879)	2.67840180
92	synaptic transmission, cholinergic (GO:0007271)	2.67442760
93	positive regulation by host of viral transcription (GO:0043923)	2.64585185
94	nephron epithelium development (GO:0072009)	2.64329909
95	protein complex biogenesis (GO:0070271)	2.63372830
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.63198662
97	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.61847672
98	positive regulation of Notch signaling pathway (GO:0045747)	2.61103100
99	glyoxylate metabolic process (GO:0046487)	2.59644517
100	base-excision repair, AP site formation (GO:0006285)	2.59349133

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.24438139
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.04042625
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.91259167
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.55824780
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.11090682
6	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.83032702
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.60433773
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.56852964
9	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.52865131
10	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.50345660
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.30786859
12	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.23539259
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.18444460
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16735689
15	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.13640522
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.13244011
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.11043690
18	REST_21632747_ChIP-Seq_MESCs_Mouse	2.03675213
19	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.81713200
20	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.81713200
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78191955
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76691633
23	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.68551605
24	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.67146035
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64218189
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.59872382
27	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.55794442
28	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.53779847
29	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.49466870
30	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.49128438
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.46875511
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46642281
33	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.46514034
34	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.44164722
35	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.40227946
36	VDR_22108803_ChIP-Seq_LS180_Human	1.35726419
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.32937544
38	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.32869056
39	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.32558572
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.32351143
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32039588
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31376171
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.27077815
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26994802
45	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25492686
46	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.24678342
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.23422475
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22877267
49	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.22283963
50	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.19959985
51	P68_20966046_ChIP-Seq_HELA_Human	1.19041093
52	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.18947466
53	BCL6_27268052_Chip-Seq_Bcells_Human	1.18299332
54	KDM2B_26808549_Chip-Seq_K562_Human	1.17545374
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17004274
56	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.16294011
57	DROSHA_22980978_ChIP-Seq_HELA_Human	1.16269167
58	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.14584286
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11096245
60	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.09294602
61	ERA_21632823_ChIP-Seq_H3396_Human	1.09207300
62	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08196812
63	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05890911
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.05615288
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04178913
66	CTCF_27219007_Chip-Seq_Bcells_Human	1.03261113
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02848308
68	OCT4_19829295_ChIP-Seq_ESCs_Human	0.99974936
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.99551323
70	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98809545
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96409750
72	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95878877
73	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95641024
74	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.95031013
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94698005
76	E2F1_20622854_ChIP-Seq_HELA_Human	0.94518957
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93808438
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93643962
79	SA1_27219007_Chip-Seq_Bcells_Human	0.92654700
80	MYC_19829295_ChIP-Seq_ESCs_Human	0.92296076
81	NCOR_22424771_ChIP-Seq_293T_Human	0.91954687
82	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.89149382
83	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.88990651
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88635315
85	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.87406135
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84536501
87	XRN2_22483619_ChIP-Seq_HELA_Human	0.84478094
88	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.83173378
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.82961391
90	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.82861322
91	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.82717956
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.81226920
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.80619833
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.80454761
95	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.80324241
96	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.80032825
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.79775286
98	VDR_21846776_ChIP-Seq_THP-1_Human	0.79383271
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.79280450
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.78839210

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.88902219
2	MP0006292_abnormal_olfactory_placode	4.92528357
3	MP0010030_abnormal_orbit_morphology	4.73786021
4	MP0008789_abnormal_olfactory_epithelium	3.24585601
5	MP0002102_abnormal_ear_morphology	3.20793702
6	MP0002653_abnormal_ependyma_morphology	3.18019304
7	MP0005394_taste/olfaction_phenotype	2.98798989
8	MP0005499_abnormal_olfactory_system	2.98798989
9	MP0000778_abnormal_nervous_system	2.52646339
10	MP0005248_abnormal_Harderian_gland	2.49632590
11	MP0003787_abnormal_imprinting	2.48563019
12	MP0003123_paternal_imprinting	2.44016272
13	MP0005646_abnormal_pituitary_gland	2.36148110
14	MP0002163_abnormal_gland_morphology	2.24128948
15	MP0001293_anophthalmia	1.99268176
16	MP0001346_abnormal_lacrimal_gland	1.92843520
17	MP0003880_abnormal_central_pattern	1.66436173
18	MP0000049_abnormal_middle_ear	1.66061646
19	MP0008775_abnormal_heart_ventricle	1.62797694
20	MP0003122_maternal_imprinting	1.54578638
21	MP0005195_abnormal_posterior_eye	1.53385549
22	MP0000015_abnormal_ear_pigmentation	1.52217717
23	MP0000955_abnormal_spinal_cord	1.48915042
24	MP0001485_abnormal_pinna_reflex	1.47506399
25	MP0004133_heterotaxia	1.44436091
26	MP0004130_abnormal_muscle_cell	1.37025096
27	MP0009053_abnormal_anal_canal	1.35855684
28	MP0000631_abnormal_neuroendocrine_gland	1.34400065
29	MP0000026_abnormal_inner_ear	1.32770675
30	MP0005551_abnormal_eye_electrophysiolog	1.32650709
31	MP0002837_dystrophic_cardiac_calcinosis	1.31232166
32	MP0001529_abnormal_vocalization	1.29789027
33	MP0004142_abnormal_muscle_tone	1.29202063
34	MP0003938_abnormal_ear_development	1.24928114
35	MP0002272_abnormal_nervous_system	1.20866118
36	MP0001324_abnormal_eye_pigmentation	1.20793011
37	MP0009278_abnormal_bone_marrow	1.20263560
38	MP0003646_muscle_fatigue	1.19451131
39	MP0003011_delayed_dark_adaptation	1.18748245
40	MP0000372_irregular_coat_pigmentation	1.17949686
41	MP0002249_abnormal_larynx_morphology	1.17411318
42	MP0002938_white_spotting	1.17268002
43	MP0001286_abnormal_eye_development	1.17120447
44	MP0003121_genomic_imprinting	1.15009965
45	MP0002233_abnormal_nose_morphology	1.13909238
46	MP0002752_abnormal_somatic_nervous	1.13801940
47	MP0002092_abnormal_eye_morphology	1.10878452
48	MP0006276_abnormal_autonomic_nervous	1.09516781
49	MP0008877_abnormal_DNA_methylation	1.09143192
50	MP0001663_abnormal_digestive_system	1.09050068
51	MP0001440_abnormal_grooming_behavior	1.08264278
52	MP0003724_increased_susceptibility_to	1.06713927
53	MP0002095_abnormal_skin_pigmentation	1.03265458
54	MP0000678_abnormal_parathyroid_gland	1.00107437
55	MP0005391_vision/eye_phenotype	0.98389962
56	MP0002876_abnormal_thyroid_physiology	0.95879027
57	MP0003878_abnormal_ear_physiology	0.95501885
58	MP0005377_hearing/vestibular/ear_phenot	0.95501885
59	MP0004742_abnormal_vestibular_system	0.95474895
60	MP0004885_abnormal_endolymph	0.94629865
61	MP0002116_abnormal_craniofacial_bone	0.92385264
62	MP0002733_abnormal_thermal_nociception	0.92162166
63	MP0002557_abnormal_social/conspecific_i	0.91004620
64	MP0002882_abnormal_neuron_morphology	0.90416994
65	MP0005379_endocrine/exocrine_gland_phen	0.90017894
66	MP0009745_abnormal_behavioral_response	0.89023816
67	MP0001986_abnormal_taste_sensitivity	0.89017164
68	MP0003635_abnormal_synaptic_transmissio	0.86924553
69	MP0002064_seizures	0.86199217
70	MP0002152_abnormal_brain_morphology	0.85540648
71	MP0002063_abnormal_learning/memory/cond	0.85431568
72	MP0001970_abnormal_pain_threshold	0.85102711
73	MP0004782_abnormal_surfactant_physiolog	0.84729232
74	MP0006072_abnormal_retinal_apoptosis	0.84096410
75	MP0005389_reproductive_system_phenotype	0.82963445
76	MP0002160_abnormal_reproductive_system	0.82908025
77	MP0000566_synostosis	0.81153900
78	MP0000428_abnormal_craniofacial_morphol	0.80663579
79	MP0002928_abnormal_bile_duct	0.80604126
80	MP0003861_abnormal_nervous_system	0.80172660
81	MP0003879_abnormal_hair_cell	0.79988098
82	MP0003283_abnormal_digestive_organ	0.77660412
83	MP0002234_abnormal_pharynx_morphology	0.76770742
84	MP0002067_abnormal_sensory_capabilities	0.76587910
85	MP0002572_abnormal_emotion/affect_behav	0.76539775
86	MP0002638_abnormal_pupillary_reflex	0.76398608
87	MP0003942_abnormal_urinary_system	0.75959279
88	MP0001270_distended_abdomen	0.74956481
89	MP0004859_abnormal_synaptic_plasticity	0.72819206
90	MP0008004_abnormal_stomach_pH	0.71854640
91	MP0001919_abnormal_reproductive_system	0.71689972
92	MP0002210_abnormal_sex_determination	0.70135379
93	MP0002184_abnormal_innervation	0.69631864
94	MP0005197_abnormal_uvea_morphology	0.65567882
95	MP0001119_abnormal_female_reproductive	0.64254244
96	MP0002734_abnormal_mechanical_nocicepti	0.63829263
97	MP0003936_abnormal_reproductive_system	0.63684436
98	MP0005174_abnormal_tail_pigmentation	0.63661998
99	MP0004134_abnormal_chest_morphology	0.62508959
100	MP0001348_abnormal_lacrimal_gland	0.62008710

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.10238288
2	Dyschromatopsia (HP:0007641)	5.07069505
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.32790227
4	Macrocytic anemia (HP:0001972)	4.02001936
5	Abnormality of midbrain morphology (HP:0002418)	3.60213730
6	Molar tooth sign on MRI (HP:0002419)	3.60213730
7	True hermaphroditism (HP:0010459)	3.55711645
8	Type II lissencephaly (HP:0007260)	3.54858891
9	Pancreatic fibrosis (HP:0100732)	3.50287941
10	Pallor (HP:0000980)	3.48364294
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.37031256
12	Decreased central vision (HP:0007663)	3.34887696
13	Septo-optic dysplasia (HP:0100842)	3.28404488
14	Adrenal hypoplasia (HP:0000835)	3.26286319
15	Medial flaring of the eyebrow (HP:0010747)	3.17637355
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.17158841
17	Hyperglycinemia (HP:0002154)	3.08604500
18	Fibular hypoplasia (HP:0003038)	3.04622177
19	Nephronophthisis (HP:0000090)	2.96972742
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.91692525
21	Progressive cerebellar ataxia (HP:0002073)	2.83631524
22	Vitreoretinal degeneration (HP:0000655)	2.83187891
23	Rib fusion (HP:0000902)	2.83161966
24	Maternal diabetes (HP:0009800)	2.82009283
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.79911798
26	Nephrogenic diabetes insipidus (HP:0009806)	2.76600492
27	Chronic hepatic failure (HP:0100626)	2.73856875
28	Abnormality of the 4th metacarpal (HP:0010012)	2.73058730
29	Abnormality of magnesium homeostasis (HP:0004921)	2.72727363
30	Metaphyseal dysplasia (HP:0100255)	2.71616424
31	Gait imbalance (HP:0002141)	2.71597877
32	Oligodactyly (hands) (HP:0001180)	2.70879307
33	Renal dysplasia (HP:0000110)	2.68950029
34	Congenital primary aphakia (HP:0007707)	2.67605290
35	Optic nerve coloboma (HP:0000588)	2.64451779
36	Depressed nasal ridge (HP:0000457)	2.63146880
37	Myokymia (HP:0002411)	2.62849346
38	Oligodactyly (HP:0012165)	2.59740684
39	Pancreatic cysts (HP:0001737)	2.58466521
40	Anencephaly (HP:0002323)	2.58218088
41	Abnormal tarsal ossification (HP:0008369)	2.58156669
42	Cystic liver disease (HP:0006706)	2.57139240
43	Growth hormone deficiency (HP:0000824)	2.55997100
44	Pendular nystagmus (HP:0012043)	2.55834231
45	Postaxial foot polydactyly (HP:0001830)	2.50518827
46	Abnormality of the renal medulla (HP:0100957)	2.48053164
47	Metaphyseal cupping (HP:0003021)	2.46832503
48	Type 2 muscle fiber atrophy (HP:0003554)	2.43262798
49	Neoplasm of the adrenal cortex (HP:0100641)	2.39980974
50	Poor coordination (HP:0002370)	2.35885921
51	Severe visual impairment (HP:0001141)	2.35493067
52	Congenital stationary night blindness (HP:0007642)	2.33199926
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.32555593
54	Short 4th metacarpal (HP:0010044)	2.31359221
55	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.31359221
56	Hip dysplasia (HP:0001385)	2.28641774
57	Abolished electroretinogram (ERG) (HP:0000550)	2.27299947
58	Abnormality of the labia minora (HP:0012880)	2.25293901
59	Hepatoblastoma (HP:0002884)	2.24732286
60	Anophthalmia (HP:0000528)	2.23556819
61	Vaginal atresia (HP:0000148)	2.21516653
62	Muscle fiber atrophy (HP:0100295)	2.21224646
63	Tubular atrophy (HP:0000092)	2.20442066
64	Hyperthyroidism (HP:0000836)	2.19471043
65	Abnormal number of erythroid precursors (HP:0012131)	2.18704412
66	3-Methylglutaconic aciduria (HP:0003535)	2.18178454
67	Peritonitis (HP:0002586)	2.08924505
68	Cerebellar dysplasia (HP:0007033)	2.08673185
69	Sclerocornea (HP:0000647)	2.08648865
70	Genital tract atresia (HP:0001827)	2.08143943
71	Congenital hepatic fibrosis (HP:0002612)	2.06353383
72	Abnormality of the aortic arch (HP:0012303)	2.05358100
73	Hypoplasia of the radius (HP:0002984)	2.04241707
74	Stenosis of the external auditory canal (HP:0000402)	2.02946608
75	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.02655334
76	Holoprosencephaly (HP:0001360)	2.02336565
77	Lissencephaly (HP:0001339)	2.01918749
78	Partial duplication of thumb phalanx (HP:0009944)	2.00202751
79	Postaxial hand polydactyly (HP:0001162)	1.99705561
80	Abnormality of the renal cortex (HP:0011035)	1.99071404
81	Hypomagnesemia (HP:0002917)	1.98464824
82	Agitation (HP:0000713)	1.97136936
83	Anterior segment dysgenesis (HP:0007700)	1.93882156
84	Acute necrotizing encephalopathy (HP:0006965)	1.92317303
85	Diastasis recti (HP:0001540)	1.91845189
86	Retinal dysplasia (HP:0007973)	1.90292348
87	Optic nerve hypoplasia (HP:0000609)	1.87889525
88	Macular degeneration (HP:0000608)	1.87729931
89	Thyroid-stimulating hormone excess (HP:0002925)	1.86383128
90	Delayed epiphyseal ossification (HP:0002663)	1.80734717
91	Porencephaly (HP:0002132)	1.80667187
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79337660
93	Parakeratosis (HP:0001036)	1.78563925
94	Forearm undergrowth (HP:0009821)	1.77632345
95	Absent septum pellucidum (HP:0001331)	1.77584682
96	Absent/shortened dynein arms (HP:0200106)	1.77433963
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.77433963
98	Bile duct proliferation (HP:0001408)	1.77275671
99	Abnormal biliary tract physiology (HP:0012439)	1.77275671
100	High anterior hairline (HP:0009890)	1.76541943

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.91073217
2	PIK3CA	3.90598271
3	MAP3K11	3.65425176
4	EPHB2	3.28934855
5	CDK19	2.67399273
6	LRRK2	2.53040024
7	WNK4	2.52047117
8	TYRO3	2.42829074
9	NTRK3	2.36243273
10	CAMK1D	2.35666141
11	DYRK1B	2.27895398
12	MAPK15	1.94348115
13	PRKD2	1.82109830
14	STK11	1.76292746
15	TIE1	1.73324170
16	WNK3	1.67960348
17	CAMK1G	1.64308966
18	DYRK2	1.60632782
19	ADRBK2	1.57369759
20	EPHA4	1.52965662
21	SIK2	1.41609834
22	MAP3K4	1.27108231
23	TRIM28	1.23333223
24	CAMK1	1.21313706
25	PRKCH	1.19869180
26	STK39	1.15525760
27	GRK1	1.11826163
28	MAP3K9	1.11279075
29	DYRK3	1.10578780
30	SGK494	1.09882592
31	SGK223	1.09882592
32	BMPR1B	1.08385474
33	CSK	1.04968489
34	MAP2K4	1.02548821
35	PRKCZ	1.00440235
36	NME1	1.00428408
37	MARK2	0.98715502
38	NUAK1	0.97128755
39	NME2	0.95937602
40	WNK1	0.94988345
41	SGK2	0.87932909
42	IKBKB	0.85356008
43	MAP2K7	0.82860228
44	BTK	0.81087707
45	CDC7	0.80723311
46	DAPK2	0.80171215
47	FRK	0.80162896
48	NTRK2	0.79157762
49	PRKD3	0.78519515
50	DMPK	0.78119502
51	PASK	0.76966839
52	CAMKK2	0.75193875
53	CAMK4	0.73046579
54	ERBB2	0.72595323
55	PRKCQ	0.71370223
56	PKN1	0.70104096
57	PRKCG	0.69693817
58	RPS6KA6	0.69358345
59	PLK4	0.68645353
60	IRAK4	0.68518163
61	TLK1	0.68306394
62	CAMKK1	0.67590637
63	FGR	0.67273074
64	GRK6	0.66473607
65	MAPK7	0.66378716
66	PRKACA	0.64170124
67	PIM1	0.63746733
68	PRKCD	0.63314857
69	MAP4K1	0.61656460
70	SIK1	0.61557322
71	SGK1	0.61021971
72	DYRK1A	0.60369671
73	SGK3	0.59335756
74	RPS6KA2	0.57791931
75	RPS6KL1	0.57492245
76	RPS6KC1	0.57492245
77	PINK1	0.57043629
78	ADRBK1	0.57028112
79	MAPK13	0.56535226
80	TYK2	0.54992911
81	MAP3K7	0.52248137
82	MATK	0.50691980
83	MARK1	0.50450015
84	CSNK2A2	0.50196549
85	MINK1	0.49829897
86	MARK3	0.49160189
87	AURKB	0.47926999
88	OXSR1	0.47722743
89	FES	0.47670649
90	ICK	0.47550330
91	PRKACG	0.47286124
92	AKT1	0.43703051
93	MAP4K2	0.43648685
94	BLK	0.43493642
95	UHMK1	0.41205765
96	GRK5	0.41101938
97	TXK	0.40154437
98	LCK	0.39127208
99	PDK2	0.38867643
100	ILK	0.36277848

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.60982491
2	Sulfur relay system_Homo sapiens_hsa04122	5.90142992
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.91597065
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.91430658
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.47451537
6	Parkinsons disease_Homo sapiens_hsa05012	2.33442454
7	Basal cell carcinoma_Homo sapiens_hsa05217	2.32014726
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21762463
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18985114
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.98374344
11	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.94875713
12	Huntingtons disease_Homo sapiens_hsa05016	1.80511018
13	Notch signaling pathway_Homo sapiens_hsa04330	1.80290689
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70642536
15	Caffeine metabolism_Homo sapiens_hsa00232	1.61891482
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.50061053
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47372542
18	RNA degradation_Homo sapiens_hsa03018	1.41113691
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37731958
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.36994515
21	RNA polymerase_Homo sapiens_hsa03020	1.33928563
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32164388
23	Regulation of autophagy_Homo sapiens_hsa04140	1.29716538
24	Alzheimers disease_Homo sapiens_hsa05010	1.29373418
25	Morphine addiction_Homo sapiens_hsa05032	1.28322215
26	Nicotine addiction_Homo sapiens_hsa05033	1.24376375
27	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.22346070
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.12157134
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07786685
30	Folate biosynthesis_Homo sapiens_hsa00790	1.06029684
31	Basal transcription factors_Homo sapiens_hsa03022	1.03392734
32	Mismatch repair_Homo sapiens_hsa03430	1.02303708
33	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99954890
34	Hippo signaling pathway_Homo sapiens_hsa04390	0.95102824
35	Phototransduction_Homo sapiens_hsa04744	0.93833659
36	One carbon pool by folate_Homo sapiens_hsa00670	0.83584718
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82513956
38	Cholinergic synapse_Homo sapiens_hsa04725	0.81628325
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80779627
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.76957122
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75200057
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.74869583
43	Axon guidance_Homo sapiens_hsa04360	0.74294557
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72698945
45	GABAergic synapse_Homo sapiens_hsa04727	0.71279505
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70108689
47	Olfactory transduction_Homo sapiens_hsa04740	0.69880467
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.66510882
49	Base excision repair_Homo sapiens_hsa03410	0.64357243
50	Circadian entrainment_Homo sapiens_hsa04713	0.63432001
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.62283547
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60734262
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.58703652
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56956922
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56487872
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55604990
57	Melanogenesis_Homo sapiens_hsa04916	0.55214696
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.54269554
59	VEGF signaling pathway_Homo sapiens_hsa04370	0.52435047
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.51460708
61	Fatty acid degradation_Homo sapiens_hsa00071	0.50954727
62	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.50820479
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48767774
64	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47902279
65	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.47754671
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.47289907
67	Serotonergic synapse_Homo sapiens_hsa04726	0.47181050
68	Butanoate metabolism_Homo sapiens_hsa00650	0.46988902
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43935840
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43399201
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42810737
72	Metabolic pathways_Homo sapiens_hsa01100	0.41769483
73	Peroxisome_Homo sapiens_hsa04146	0.40346962
74	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.39763480
75	Insulin secretion_Homo sapiens_hsa04911	0.39723986
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39409145
77	Retinol metabolism_Homo sapiens_hsa00830	0.39395672
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.37789654
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37185010
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36841038
81	Chemokine signaling pathway_Homo sapiens_hsa04062	0.36084622
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34961637
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.34299287
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33498842
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32047045
86	Ras signaling pathway_Homo sapiens_hsa04014	0.31294651
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27022746
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.24796096
89	Purine metabolism_Homo sapiens_hsa00230	0.24407137
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19681544
91	p53 signaling pathway_Homo sapiens_hsa04115	0.19517486
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.19038221
93	Choline metabolism in cancer_Homo sapiens_hsa05231	0.17772489
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.17424769
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.17337738
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.17299179
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.16628981
98	Rap1 signaling pathway_Homo sapiens_hsa04015	0.16588063
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.16114444
100	DNA replication_Homo sapiens_hsa03030	0.14769313

RPS15AP27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »