ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intra-S DNA damage checkpoint (GO:0031573)	8.93097823
2	DNA replication checkpoint (GO:0000076)	7.43298173
3	regulation of nuclear cell cycle DNA replication (GO:0033262)	6.57326634
4	neural tube formation (GO:0001841)	6.46908086
5	mature B cell differentiation (GO:0002335)	5.97028559
6	hepatocyte apoptotic process (GO:0097284)	5.92002479
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	5.59961392
8	neuron fate determination (GO:0048664)	5.52088946
9	fatty acid transmembrane transport (GO:1902001)	5.13408305
10	presynaptic membrane assembly (GO:0097105)	4.43065802
11	cerebral cortex radially oriented cell migration (GO:0021799)	4.41631596
12	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	4.35223975
13	telencephalon development (GO:0021537)	4.18522712
14	protein localization to synapse (GO:0035418)	4.18056717
15	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.17852527
16	sequestering of actin monomers (GO:0042989)	4.10031887
17	retinal ganglion cell axon guidance (GO:0031290)	4.10007183
18	tongue development (GO:0043586)	4.08461067
19	presynaptic membrane organization (GO:0097090)	3.92247823
20	positive regulation of synapse assembly (GO:0051965)	3.84837073
21	dendritic spine morphogenesis (GO:0060997)	3.83377649
22	neurotransmitter-gated ion channel clustering (GO:0072578)	3.71372764
23	synaptic vesicle maturation (GO:0016188)	3.64021255
24	aldehyde catabolic process (GO:0046185)	3.53336002
25	ribosomal small subunit assembly (GO:0000028)	3.52561943
26	behavioral response to nicotine (GO:0035095)	3.52346009
27	intraciliary transport (GO:0042073)	3.51791292
28	spinal cord association neuron differentiation (GO:0021527)	3.49831414
29	central nervous system myelination (GO:0022010)	3.44421734
30	axon ensheathment in central nervous system (GO:0032291)	3.44421734
31	histone H4-K12 acetylation (GO:0043983)	3.40611184
32	cranial nerve morphogenesis (GO:0021602)	3.30902567
33	regulation of mitotic spindle checkpoint (GO:1903504)	3.27763289
34	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.27763289
35	response to pheromone (GO:0019236)	3.25511222
36	negative regulation of organ growth (GO:0046621)	3.22882591
37	protein neddylation (GO:0045116)	3.21478026
38	cellular ketone body metabolic process (GO:0046950)	3.17967249
39	positive regulation of vesicle fusion (GO:0031340)	3.17843742
40	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.16971610
41	translational termination (GO:0006415)	3.14119657
42	viral transcription (GO:0019083)	3.10313694
43	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.09913553
44	protein localization to cilium (GO:0061512)	3.04812823
45	ubiquinone biosynthetic process (GO:0006744)	2.97304666
46	ketone body metabolic process (GO:1902224)	2.96246029
47	midbrain development (GO:0030901)	2.96079276
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.96026351
49	glutamate secretion (GO:0014047)	2.94778606
50	cell differentiation involved in embryonic placenta development (GO:0060706)	2.94174448
51	central nervous system projection neuron axonogenesis (GO:0021952)	2.93619344
52	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.91715147
53	oxidative demethylation (GO:0070989)	2.90661150
54	glycerophospholipid catabolic process (GO:0046475)	2.88571417
55	ubiquinone metabolic process (GO:0006743)	2.87714993
56	cGMP-mediated signaling (GO:0019934)	2.87275361
57	apical protein localization (GO:0045176)	2.84591978
58	mannosylation (GO:0097502)	2.84479228
59	regulation of mesoderm development (GO:2000380)	2.83834188
60	chaperone-mediated protein transport (GO:0072321)	2.83559964
61	regulation of axon extension involved in axon guidance (GO:0048841)	2.83513520
62	lens morphogenesis in camera-type eye (GO:0002089)	2.82031837
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.79518709
64	positive regulation of Notch signaling pathway (GO:0045747)	2.79109390
65	regulation of synapse assembly (GO:0051963)	2.74084072
66	embryonic epithelial tube formation (GO:0001838)	2.73083036
67	N-terminal protein amino acid acetylation (GO:0006474)	2.68276628
68	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.65170601
69	neuron cell-cell adhesion (GO:0007158)	2.63845184
70	regulation of axon guidance (GO:1902667)	2.62655223
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62573408
72	establishment of mitochondrion localization (GO:0051654)	2.61111350
73	nonmotile primary cilium assembly (GO:0035058)	2.60612453
74	hematopoietic stem cell proliferation (GO:0071425)	2.58757424
75	negative regulation of axon guidance (GO:1902668)	2.57988392
76	arginine catabolic process (GO:0006527)	2.57766969
77	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.57121374
78	carnitine shuttle (GO:0006853)	2.56986279
79	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56546836
80	NADH dehydrogenase complex assembly (GO:0010257)	2.56546836
81	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56546836
82	epithelial tube formation (GO:0072175)	2.55697291
83	pattern specification involved in kidney development (GO:0061004)	2.53290645
84	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.53121438
85	establishment of monopolar cell polarity (GO:0061162)	2.53121438
86	phagocytosis, recognition (GO:0006910)	2.53056919
87	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52186182
88	DNA methylation involved in gamete generation (GO:0043046)	2.52061872
89	polarized epithelial cell differentiation (GO:0030859)	2.51732820
90	ATP synthesis coupled proton transport (GO:0015986)	2.50627901
91	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.50627901
92	negative regulation of DNA binding (GO:0043392)	2.49954036
93	neuronal stem cell maintenance (GO:0097150)	2.49354824
94	postsynaptic membrane organization (GO:0001941)	2.49047637
95	C4-dicarboxylate transport (GO:0015740)	2.48643217
96	alanine transport (GO:0032328)	2.47944919
97	auditory behavior (GO:0031223)	2.47452188
98	cerebellar Purkinje cell layer development (GO:0021680)	2.46794931
99	cochlea development (GO:0090102)	2.46351339
100	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.45137231

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.96421751
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.87633580
3	ZNF274_21170338_ChIP-Seq_K562_Hela	4.09073925
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.87044356
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.34778435
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82606723
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.49374967
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.42071010
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.34241013
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.33914789
11	REST_21632747_ChIP-Seq_MESCs_Mouse	2.28694940
12	VDR_22108803_ChIP-Seq_LS180_Human	2.22842394
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.22648338
14	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.20898436
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14049457
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.11760406
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09977147
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.04888794
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.02293411
20	FUS_26573619_Chip-Seq_HEK293_Human	1.95437448
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.80993067
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.78176562
23	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.74411032
24	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.74237070
25	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.70224473
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.65966459
27	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.63911646
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.62084023
29	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.61693427
30	P300_19829295_ChIP-Seq_ESCs_Human	1.58188464
31	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.51009727
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50762427
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.46494439
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41419945
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.40569123
36	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.40569123
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40332384
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39205302
39	DROSHA_22980978_ChIP-Seq_HELA_Human	1.38598618
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.37920453
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36042781
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35194440
43	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34688411
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32552108
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29201728
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.28337915
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28337915
48	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28165589
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27177386
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.26943836
51	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.25961841
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25488473
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.25302556
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.21409180
55	STAT3_23295773_ChIP-Seq_U87_Human	1.20926705
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19763744
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17979174
58	AR_25329375_ChIP-Seq_VCAP_Human	1.17134476
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16325316
60	JUN_21703547_ChIP-Seq_K562_Human	1.15947196
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14810099
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13483938
63	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.12542627
64	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09161172
65	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.07913809
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05418565
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03244500
68	TCF4_23295773_ChIP-Seq_U87_Human	1.03042049
69	NCOR_22424771_ChIP-Seq_293T_Human	1.02200217
70	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00987589
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00613112
72	ERA_21632823_ChIP-Seq_H3396_Human	0.98112226
73	EWS_26573619_Chip-Seq_HEK293_Human	0.97786122
74	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97711367
75	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.97155558
76	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.96894883
77	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.94027124
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.94024111
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92830885
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92552086
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92546348
82	AR_21572438_ChIP-Seq_LNCaP_Human	0.91676097
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91460828
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.90922054
85	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.90276150
86	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.88988379
87	TP53_18474530_ChIP-ChIP_U2OS_Human	0.88368006
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88356354
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87354351
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87288861
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87055869
92	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.87017580
93	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.86750365
94	SOX2_21211035_ChIP-Seq_LN229_Human	0.86039791
95	TP53_16413492_ChIP-PET_HCT116_Human	0.84507494
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84156631
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.83203808
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82137589
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.82071205
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.81765527

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	7.69041190
2	MP0002163_abnormal_gland_morphology	4.33215563
3	MP0002653_abnormal_ependyma_morphology	4.00731105
4	MP0000566_synostosis	3.64860492
5	MP0005379_endocrine/exocrine_gland_phen	2.96755518
6	MP0002837_dystrophic_cardiac_calcinosis	2.53198745
7	MP0003183_abnormal_peptide_metabolism	2.29929552
8	MP0006292_abnormal_olfactory_placode	2.20333353
9	MP0003011_delayed_dark_adaptation	2.17994774
10	MP0004264_abnormal_extraembryonic_tissu	2.08256255
11	MP0004742_abnormal_vestibular_system	2.05204093
12	MP0005670_abnormal_white_adipose	1.97756792
13	MP0005423_abnormal_somatic_nervous	1.85347520
14	MP0002938_white_spotting	1.77465849
15	MP0003195_calcinosis	1.74777106
16	MP0004142_abnormal_muscle_tone	1.72502733
17	MP0002736_abnormal_nociception_after	1.70600145
18	MP0003638_abnormal_response/metabolism_	1.68740131
19	MP0005551_abnormal_eye_electrophysiolog	1.65164077
20	MP0002277_abnormal_respiratory_mucosa	1.61229237
21	MP0000778_abnormal_nervous_system	1.61114984
22	MP0003635_abnormal_synaptic_transmissio	1.59365502
23	MP0000372_irregular_coat_pigmentation	1.59101261
24	MP0005174_abnormal_tail_pigmentation	1.48499564
25	MP0001968_abnormal_touch/_nociception	1.48008278
26	MP0004381_abnormal_hair_follicle	1.47350172
27	MP0003880_abnormal_central_pattern	1.46306420
28	MP0001485_abnormal_pinna_reflex	1.45913686
29	MP0002272_abnormal_nervous_system	1.45497200
30	MP0000955_abnormal_spinal_cord	1.41206149
31	MP0004859_abnormal_synaptic_plasticity	1.39758573
32	MP0002557_abnormal_social/conspecific_i	1.39730662
33	MP0001486_abnormal_startle_reflex	1.35785061
34	MP0005187_abnormal_penis_morphology	1.33445285
35	MP0008877_abnormal_DNA_methylation	1.32375738
36	MP0004043_abnormal_pH_regulation	1.31124158
37	MP0002095_abnormal_skin_pigmentation	1.28090831
38	MP0002249_abnormal_larynx_morphology	1.27816560
39	MP0004130_abnormal_muscle_cell	1.27230276
40	MP0003567_abnormal_fetal_cardiomyocyte	1.26606576
41	MP0005171_absent_coat_pigmentation	1.25227613
42	MP0002734_abnormal_mechanical_nocicepti	1.20204026
43	MP0000631_abnormal_neuroendocrine_gland	1.18699610
44	MP0008872_abnormal_physiological_respon	1.17789161
45	MP0000569_abnormal_digit_pigmentation	1.16895082
46	MP0002572_abnormal_emotion/affect_behav	1.14589066
47	MP0002752_abnormal_somatic_nervous	1.12905660
48	MP0009764_decreased_sensitivity_to	1.12489946
49	MP0001970_abnormal_pain_threshold	1.10099240
50	MP0002064_seizures	1.09725001
51	MP0006276_abnormal_autonomic_nervous	1.09242131
52	MP0002184_abnormal_innervation	1.08379438
53	MP0001440_abnormal_grooming_behavior	1.07884029
54	MP0002063_abnormal_learning/memory/cond	1.05888311
55	MP0009046_muscle_twitch	1.03867675
56	MP0002876_abnormal_thyroid_physiology	1.03610741
57	MP0001986_abnormal_taste_sensitivity	1.03288680
58	MP0005195_abnormal_posterior_eye	1.03160724
59	MP0003646_muscle_fatigue	1.00352168
60	MP0000049_abnormal_middle_ear	1.00267134
61	MP0002733_abnormal_thermal_nociception	0.99574418
62	MP0001529_abnormal_vocalization	0.97834276
63	MP0001293_anophthalmia	0.97677508
64	MP0005253_abnormal_eye_physiology	0.97410883
65	MP0001299_abnormal_eye_distance/	0.97264830
66	MP0003938_abnormal_ear_development	0.96705179
67	MP0009745_abnormal_behavioral_response	0.95895870
68	MP0004924_abnormal_behavior	0.94144419
69	MP0005386_behavior/neurological_phenoty	0.94144419
70	MP0005646_abnormal_pituitary_gland	0.92526232
71	MP0004270_analgesia	0.92149945
72	MP0000026_abnormal_inner_ear	0.90935239
73	MP0004133_heterotaxia	0.90269953
74	MP0003315_abnormal_perineum_morphology	0.89876460
75	MP0001984_abnormal_olfaction	0.85691580
76	MP0002882_abnormal_neuron_morphology	0.84155002
77	MP0003861_abnormal_nervous_system	0.82502318
78	MP0002075_abnormal_coat/hair_pigmentati	0.82250946
79	MP0005394_taste/olfaction_phenotype	0.82057723
80	MP0005499_abnormal_olfactory_system	0.82057723
81	MP0002067_abnormal_sensory_capabilities	0.81725301
82	MP0000613_abnormal_salivary_gland	0.78967298
83	MP0004145_abnormal_muscle_electrophysio	0.78886242
84	MP0005410_abnormal_fertilization	0.73966733
85	MP0008569_lethality_at_weaning	0.73601499
86	MP0005083_abnormal_biliary_tract	0.73522296
87	MP0002152_abnormal_brain_morphology	0.71891710
88	MP0009384_cardiac_valve_regurgitation	0.70348524
89	MP0008789_abnormal_olfactory_epithelium	0.69974619
90	MP0002735_abnormal_chemical_nociception	0.69945659
91	MP0010030_abnormal_orbit_morphology	0.69675906
92	MP0002822_catalepsy	0.69671551
93	MP0000579_abnormal_nail_morphology	0.69582153
94	MP0005391_vision/eye_phenotype	0.69417694
95	MP0002234_abnormal_pharynx_morphology	0.69327479
96	MP0002638_abnormal_pupillary_reflex	0.69139218
97	MP0004885_abnormal_endolymph	0.68890817
98	MP0002160_abnormal_reproductive_system	0.67933923
99	MP0003787_abnormal_imprinting	0.67618837
100	MP0000015_abnormal_ear_pigmentation	0.67073730

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Impulsivity (HP:0100710)	4.83630146
2	Septo-optic dysplasia (HP:0100842)	3.86094837
3	Type II lissencephaly (HP:0007260)	3.77730844
4	Abnormality of the aortic arch (HP:0012303)	3.77520090
5	Medial flaring of the eyebrow (HP:0010747)	3.63707961
6	Abnormality of the nasal septum (HP:0000419)	3.56382699
7	Abnormality of incisor morphology (HP:0011063)	3.51440279
8	Parakeratosis (HP:0001036)	3.48759885
9	Carpal bone hypoplasia (HP:0001498)	3.47389172
10	Nasolacrimal duct obstruction (HP:0000579)	3.46914305
11	Flared iliac wings (HP:0002869)	3.46214895
12	Cerebellar dysplasia (HP:0007033)	3.39593123
13	Tubulointerstitial nephritis (HP:0001970)	3.35842807
14	Poor coordination (HP:0002370)	3.31932331
15	Gait imbalance (HP:0002141)	3.22839055
16	Abnormal hair whorl (HP:0010721)	3.05657446
17	Respiratory difficulties (HP:0002880)	3.05025922
18	Agitation (HP:0000713)	3.01917075
19	Acute necrotizing encephalopathy (HP:0006965)	2.93457239
20	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.88926999
21	Oligodactyly (hands) (HP:0001180)	2.87068031
22	Abnormality of the phalanges of the hallux (HP:0010057)	2.83366405
23	Abnormality of the lacrimal duct (HP:0011481)	2.78633407
24	Abnormality of the diencephalon (HP:0010662)	2.70153834
25	Pancreatic fibrosis (HP:0100732)	2.69484441
26	Abnormality of the nasolacrimal system (HP:0000614)	2.63121293
27	Congenital primary aphakia (HP:0007707)	2.56033998
28	Shawl scrotum (HP:0000049)	2.55966865
29	Obstructive sleep apnea (HP:0002870)	2.54213472
30	Optic nerve hypoplasia (HP:0000609)	2.53570507
31	Absent eyebrow (HP:0002223)	2.51696852
32	Rib fusion (HP:0000902)	2.51272823
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49696043
34	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.44284718
35	Concave nail (HP:0001598)	2.43480685
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41132370
37	Nephronophthisis (HP:0000090)	2.37796128
38	Oligodactyly (HP:0012165)	2.37010457
39	Hypoplasia of the pons (HP:0012110)	2.36799397
40	Esophageal atresia (HP:0002032)	2.35499047
41	Acute encephalopathy (HP:0006846)	2.34724143
42	Nephrogenic diabetes insipidus (HP:0009806)	2.27162482
43	Abnormality of the parietal bone (HP:0002696)	2.26192480
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.26086583
45	Conical tooth (HP:0000698)	2.25778662
46	Pancreatic cysts (HP:0001737)	2.24338265
47	Lissencephaly (HP:0001339)	2.22854043
48	Progressive macrocephaly (HP:0004481)	2.22574486
49	Polyphagia (HP:0002591)	2.18538770
50	Elfin facies (HP:0004428)	2.17644744
51	Genital tract atresia (HP:0001827)	2.16473152
52	Abnormality of the pons (HP:0007361)	2.15555041
53	Overriding aorta (HP:0002623)	2.15394809
54	Vaginal atresia (HP:0000148)	2.14722386
55	Megalocornea (HP:0000485)	2.14073548
56	Hip dysplasia (HP:0001385)	2.13570266
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.13359671
58	Febrile seizures (HP:0002373)	2.12299277
59	Sclerocornea (HP:0000647)	2.10481639
60	True hermaphroditism (HP:0010459)	2.06746888
61	Hyperventilation (HP:0002883)	2.06679345
62	Broad alveolar ridges (HP:0000187)	2.06398725
63	Postaxial foot polydactyly (HP:0001830)	2.05772842
64	Absent septum pellucidum (HP:0001331)	2.03824050
65	Diastasis recti (HP:0001540)	2.02610042
66	Renovascular hypertension (HP:0100817)	2.02042739
67	Pachygyria (HP:0001302)	2.02040787
68	Abnormality of the middle phalanges of the toes (HP:0010183)	2.00892789
69	Abnormality of the dental root (HP:0006486)	1.98088350
70	Taurodontia (HP:0000679)	1.98088350
71	Abnormality of permanent molar morphology (HP:0011071)	1.98088350
72	Severe muscular hypotonia (HP:0006829)	1.96275993
73	Myokymia (HP:0002411)	1.95584598
74	Chronic hepatic failure (HP:0100626)	1.92003969
75	Mitochondrial inheritance (HP:0001427)	1.91392583
76	Abnormality of the lower motor neuron (HP:0002366)	1.91211691
77	Supernumerary spleens (HP:0009799)	1.91099181
78	Flat cornea (HP:0007720)	1.89169301
79	Long toe (HP:0010511)	1.88245568
80	Amyotrophic lateral sclerosis (HP:0007354)	1.85524764
81	Abnormality of molar (HP:0011077)	1.84259663
82	Abnormality of molar morphology (HP:0011070)	1.84259663
83	Drooling (HP:0002307)	1.83067433
84	Optic disc pallor (HP:0000543)	1.80416860
85	Hepatocellular necrosis (HP:0001404)	1.78574302
86	Capillary hemangiomas (HP:0005306)	1.77851009
87	Spastic tetraparesis (HP:0001285)	1.76130211
88	Abnormality of the dental pulp (HP:0006479)	1.75557688
89	Reticulocytopenia (HP:0001896)	1.72302774
90	Abnormality of the incisor (HP:0000676)	1.71483807
91	Abnormality of the renal medulla (HP:0100957)	1.71129644
92	Broad hallux (HP:0010055)	1.70164861
93	Left ventricular hypertrophy (HP:0001712)	1.69284199
94	Hypoplastic ilia (HP:0000946)	1.69189898
95	Broad-based gait (HP:0002136)	1.68992629
96	Abnormality of midbrain morphology (HP:0002418)	1.68931331
97	Molar tooth sign on MRI (HP:0002419)	1.68931331
98	Absent speech (HP:0001344)	1.68181101
99	Hypoplastic iliac wings (HP:0002866)	1.68074576
100	Small hand (HP:0200055)	1.67742098

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.49345534
2	TNIK	4.27597364
3	STK3	4.24193779
4	PDK2	4.06174366
5	MARK1	3.57377033
6	EPHA3	2.93264797
7	MAPK13	2.35656949
8	WNK4	1.97726480
9	PAK3	1.90240322
10	PRKCQ	1.81880620
11	DYRK2	1.81396618
12	PINK1	1.80458509
13	ADRBK2	1.80272348
14	CAMK4	1.69240741
15	CAMKK2	1.67824400
16	FRK	1.63996096
17	PHKG2	1.45505238
18	PHKG1	1.45505238
19	TLK1	1.42391181
20	PNCK	1.42257309
21	IRAK1	1.36081975
22	GRK1	1.33199898
23	BMPR1B	1.30467615
24	STK16	1.29824269
25	WNK3	1.26974007
26	CSNK1A1	1.26163678
27	SGK1	1.20652459
28	AKT3	1.20303934
29	CAMK1	1.16064789
30	PRKCZ	1.12291465
31	DAPK2	1.11666344
32	TGFBR1	1.10058889
33	CAMKK1	1.03728571
34	TNK2	1.02625471
35	CAMK1G	0.96707038
36	DYRK1A	0.96272993
37	MAP4K2	0.96112714
38	ADRBK1	0.94238537
39	ACVR1B	0.93518187
40	EPHA4	0.89350682
41	PAK6	0.88460225
42	NEK2	0.88236650
43	FGFR1	0.88158778
44	ERBB4	0.87188276
45	MAPK12	0.87036561
46	EPHB2	0.86667334
47	MINK1	0.84746529
48	IRAK3	0.82888426
49	PRKCG	0.82386040
50	SGK2	0.82198817
51	EPHB1	0.78540282
52	DYRK3	0.78050397
53	PRKCI	0.76458115
54	SGK223	0.74135363
55	SGK494	0.74135363
56	PRKACA	0.73379913
57	MAP2K7	0.72043547
58	STK11	0.69952885
59	INSRR	0.69443322
60	PKN1	0.68374637
61	NME1	0.66419761
62	NTRK2	0.64941935
63	MAP3K4	0.63152052
64	CSNK1D	0.63043980
65	ABL1	0.60623283
66	CAMK2A	0.60177465
67	MAPK15	0.58502469
68	PLK2	0.58205580
69	ABL2	0.58164686
70	GRK7	0.57179764
71	CSNK2A2	0.56315095
72	RPS6KA3	0.56250103
73	FER	0.55873464
74	STK39	0.55762092
75	TYRO3	0.54873674
76	LRRK2	0.54570328
77	MARK2	0.53982921
78	ERBB3	0.51860307
79	ZAK	0.51098829
80	PRKCA	0.50585638
81	IRAK2	0.50312559
82	PRKG1	0.49632663
83	PRKCE	0.49100370
84	PRKDC	0.48299003
85	CDK5	0.46646952
86	OXSR1	0.46252688
87	PRKCD	0.44674992
88	WNK1	0.43593063
89	CHUK	0.43331286
90	AKT1	0.42110610
91	TEC	0.41461319
92	PRKCB	0.41132383
93	OBSCN	0.37925700
94	IRAK4	0.37457966
95	SGK3	0.35356368
96	CSNK1E	0.33822124
97	CAMK1D	0.31270337
98	ATM	0.28465097
99	DDR2	0.27955051
100	PRKACB	0.27073701

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.04206077
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.92071729
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.77979912
4	Parkinsons disease_Homo sapiens_hsa05012	2.45896734
5	Phototransduction_Homo sapiens_hsa04744	2.42545472
6	Nicotine addiction_Homo sapiens_hsa05033	2.30400996
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.27765697
8	Huntingtons disease_Homo sapiens_hsa05016	2.22105315
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.18612534
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96615937
11	Sulfur relay system_Homo sapiens_hsa04122	1.80267772
12	Alzheimers disease_Homo sapiens_hsa05010	1.73423424
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69941503
14	Insulin secretion_Homo sapiens_hsa04911	1.60354133
15	Notch signaling pathway_Homo sapiens_hsa04330	1.59777797
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56900269
17	Axon guidance_Homo sapiens_hsa04360	1.54275144
18	Propanoate metabolism_Homo sapiens_hsa00640	1.52018711
19	Proteasome_Homo sapiens_hsa03050	1.43384629
20	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.43022224
21	Olfactory transduction_Homo sapiens_hsa04740	1.42612494
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39599709
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39546143
24	Fatty acid degradation_Homo sapiens_hsa00071	1.35773089
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35772903
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31988660
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31598519
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31026700
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.24924694
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24745463
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.24144597
32	Basal cell carcinoma_Homo sapiens_hsa05217	1.23020168
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22891404
34	Basal transcription factors_Homo sapiens_hsa03022	1.22737131
35	Glycerolipid metabolism_Homo sapiens_hsa00561	1.19363903
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16301757
37	Caffeine metabolism_Homo sapiens_hsa00232	1.15631381
38	Butanoate metabolism_Homo sapiens_hsa00650	1.14877847
39	Cocaine addiction_Homo sapiens_hsa05030	1.12202072
40	Peroxisome_Homo sapiens_hsa04146	1.10863006
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.09231350
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08425443
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.05684701
44	Melanogenesis_Homo sapiens_hsa04916	1.04924470
45	Taste transduction_Homo sapiens_hsa04742	1.04426879
46	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.02747934
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99289579
48	Sulfur metabolism_Homo sapiens_hsa00920	0.99176322
49	GABAergic synapse_Homo sapiens_hsa04727	0.99160602
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.95845461
51	Morphine addiction_Homo sapiens_hsa05032	0.95652948
52	Homologous recombination_Homo sapiens_hsa03440	0.93565003
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92022181
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91820336
55	Salivary secretion_Homo sapiens_hsa04970	0.90585913
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87649808
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.87442634
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.87240397
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86577687
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.85225118
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84406628
62	PPAR signaling pathway_Homo sapiens_hsa03320	0.84102529
63	Glucagon signaling pathway_Homo sapiens_hsa04922	0.84039407
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81317286
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.80705324
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.80585259
67	Retinol metabolism_Homo sapiens_hsa00830	0.79307216
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78887060
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77470731
70	RNA degradation_Homo sapiens_hsa03018	0.75297175
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.75272332
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74614360
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.70276768
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68478859
75	Gastric acid secretion_Homo sapiens_hsa04971	0.68256491
76	Long-term depression_Homo sapiens_hsa04730	0.67041479
77	ABC transporters_Homo sapiens_hsa02010	0.66970495
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66109871
79	Circadian entrainment_Homo sapiens_hsa04713	0.64590121
80	Serotonergic synapse_Homo sapiens_hsa04726	0.61728237
81	Cholinergic synapse_Homo sapiens_hsa04725	0.61618274
82	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60685035
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56508327
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.56086478
85	RNA polymerase_Homo sapiens_hsa03020	0.56052849
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56023639
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.55628971
88	Metabolic pathways_Homo sapiens_hsa01100	0.55582877
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53663334
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.50878752
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49929441
92	Bile secretion_Homo sapiens_hsa04976	0.49645087
93	Regulation of autophagy_Homo sapiens_hsa04140	0.48386380
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47490025
95	Mineral absorption_Homo sapiens_hsa04978	0.46573608
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46288621
97	Gap junction_Homo sapiens_hsa04540	0.43937989
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.43846491
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40875272
100	Amphetamine addiction_Homo sapiens_hsa05031	0.38976056

RPS15AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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