ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	8.75499432
2	protein-chromophore linkage (GO:0018298)	8.68828406
3	lipopolysaccharide biosynthetic process (GO:0009103)	8.67851328
4	DNA methylation involved in gamete generation (GO:0043046)	7.99644652
5	lipopolysaccharide metabolic process (GO:0008653)	7.93287813
6	regulation of meiosis I (GO:0060631)	7.79953371
7	positive regulation of developmental pigmentation (GO:0048087)	7.69957121
8	regulation of pigment cell differentiation (GO:0050932)	7.36019828
9	regulation of protein glycosylation (GO:0060049)	7.35648637
10	negative regulation of glycoprotein biosynthetic process (GO:0010561)	6.77471268
11	sulfate transmembrane transport (GO:1902358)	6.73081537
12	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	6.67486265
13	paraxial mesoderm development (GO:0048339)	6.02347826
14	negative regulation of cell cycle G2/M phase transition (GO:1902750)	5.93233588
15	piRNA metabolic process (GO:0034587)	5.80681271
16	sulfate transport (GO:0008272)	5.70323052
17	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	5.64513067
18	DNA damage induced protein phosphorylation (GO:0006975)	5.58015928
19	negative regulation of glycoprotein metabolic process (GO:1903019)	4.96409837
20	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.79946604
21	L-phenylalanine catabolic process (GO:0006559)	4.79946604
22	centriole replication (GO:0007099)	4.79484308
23	vitamin transmembrane transport (GO:0035461)	4.69024527
24	germinal center formation (GO:0002467)	4.49776190
25	tyrosine metabolic process (GO:0006570)	4.42164828
26	notochord development (GO:0030903)	4.41344975
27	heme transport (GO:0015886)	4.39011397
28	positive regulation of meiosis (GO:0045836)	4.37543873
29	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.36128824
30	SMAD protein complex assembly (GO:0007183)	4.32754321
31	inflammatory response to antigenic stimulus (GO:0002437)	4.17872058
32	meiotic chromosome segregation (GO:0045132)	4.16684593
33	positive regulation of meiotic cell cycle (GO:0051446)	4.05500709
34	L-phenylalanine metabolic process (GO:0006558)	4.02626503
35	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.02626503
36	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.98455024
37	serotonin receptor signaling pathway (GO:0007210)	3.91003908
38	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.86797359
39	glycerol metabolic process (GO:0006071)	3.80404373
40	negative regulation of stem cell proliferation (GO:2000647)	3.76746750
41	regulation of odontogenesis (GO:0042481)	3.75092818
42	ribonucleoprotein complex disassembly (GO:0032988)	3.74632071
43	response to mercury ion (GO:0046689)	3.70403835
44	nodal signaling pathway (GO:0038092)	3.66418515
45	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.65475665
46	regulation of developmental pigmentation (GO:0048070)	3.63433533
47	transcription from mitochondrial promoter (GO:0006390)	3.63001880
48	tachykinin receptor signaling pathway (GO:0007217)	3.62905105
49	rhodopsin mediated signaling pathway (GO:0016056)	3.60814517
50	regulation of transforming growth factor beta2 production (GO:0032909)	3.57321592
51	interkinetic nuclear migration (GO:0022027)	3.53744315
52	heart valve formation (GO:0003188)	3.53460020
53	sulfur compound transport (GO:0072348)	3.50585722
54	flavonoid metabolic process (GO:0009812)	3.50254531
55	regulation of interleukin-5 production (GO:0032674)	3.43158878
56	alditol metabolic process (GO:0019400)	3.40618257
57	cellular response to gamma radiation (GO:0071480)	3.36539577
58	aromatic amino acid family catabolic process (GO:0009074)	3.33332759
59	toxin metabolic process (GO:0009404)	3.32364375
60	regulation of neuroblast proliferation (GO:1902692)	3.32215948
61	negative regulation of cell-matrix adhesion (GO:0001953)	3.19439853
62	iron coordination entity transport (GO:1901678)	3.17834631
63	proline biosynthetic process (GO:0006561)	3.16806214
64	regulation of hair follicle development (GO:0051797)	3.16491296
65	centriole assembly (GO:0098534)	3.16444233
66	somite rostral/caudal axis specification (GO:0032525)	3.14923217
67	pantothenate metabolic process (GO:0015939)	3.13440053
68	organ induction (GO:0001759)	3.13238035
69	DNA alkylation (GO:0006305)	3.13071203
70	DNA methylation (GO:0006306)	3.13071203
71	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	3.12806201
72	positive regulation of chondrocyte differentiation (GO:0032332)	3.07174829
73	sympathetic nervous system development (GO:0048485)	3.07026767
74	regulation of keratinocyte proliferation (GO:0010837)	3.05583702
75	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.04221377
76	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.03336609
77	negative regulation of neural precursor cell proliferation (GO:2000178)	2.98483281
78	response to epinephrine (GO:0071871)	2.96630284
79	glycerophospholipid catabolic process (GO:0046475)	2.94865467
80	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.94497686
81	aromatic amino acid family metabolic process (GO:0009072)	2.88076326
82	adaptation of signaling pathway (GO:0023058)	2.88044979
83	cofactor transport (GO:0051181)	2.87442458
84	aspartate family amino acid catabolic process (GO:0009068)	2.86792853
85	cytokine biosynthetic process (GO:0042089)	2.85315953
86	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.85098044
87	organelle disassembly (GO:1903008)	2.82629593
88	positive regulation of viral genome replication (GO:0045070)	2.80879901
89	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	2.79739793
90	urate metabolic process (GO:0046415)	2.72722595
91	protein retention in ER lumen (GO:0006621)	2.68446531
92	left/right axis specification (GO:0070986)	2.66739558
93	organic cation transport (GO:0015695)	2.55011769
94	regulation of chemokine biosynthetic process (GO:0045073)	2.54869088
95	membrane lipid biosynthetic process (GO:0046467)	2.53554219
96	CDP-diacylglycerol metabolic process (GO:0046341)	2.50646207
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.50621271
98	sphingosine metabolic process (GO:0006670)	15.0909598
99	diol metabolic process (GO:0034311)	13.5729477
100	sphingoid metabolic process (GO:0046519)	12.3544562

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.33354522
2	AR_21572438_ChIP-Seq_LNCaP_Human	4.52828927
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	4.41627076
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.36378035
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.12418784
6	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.91212878
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61401847
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48030834
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25992173
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14599530
11	VDR_22108803_ChIP-Seq_LS180_Human	2.14021118
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06645503
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.04237420
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.91069761
15	P300_19829295_ChIP-Seq_ESCs_Human	1.90967699
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.90567328
17	HOXB7_26014856_ChIP-Seq_BT474_Human	1.79294999
18	EGR1_19032775_ChIP-ChIP_M12_Human	1.77893709
19	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.75149792
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74679218
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67185343
22	SCL_19346495_ChIP-Seq_HPC-7_Human	1.60822186
23	SOX2_19829295_ChIP-Seq_ESCs_Human	1.59118171
24	NANOG_19829295_ChIP-Seq_ESCs_Human	1.59118171
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58726563
26	STAT1_20625510_ChIP-Seq_HELA_Human	1.58693347
27	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.54651386
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54019856
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53869465
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53776839
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53436077
32	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51164288
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48473243
34	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.47895791
35	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.47637542
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41086747
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40388161
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38519897
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.38440810
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38440810
41	TCF4_23295773_ChIP-Seq_U87_Human	1.38245970
42	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.38143109
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35167363
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34776175
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34776175
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31720362
47	OCT4_20526341_ChIP-Seq_ESCs_Human	1.31632117
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.30914627
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.30502648
50	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.29585453
51	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.28954177
52	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28887682
53	NCOR_22424771_ChIP-Seq_293T_Human	1.28469021
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26826631
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26536938
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26536938
57	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.25364242
58	STAT3_23295773_ChIP-Seq_U87_Human	1.22577082
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22358034
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22256855
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.21112387
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19711561
63	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.19265796
64	AR_25329375_ChIP-Seq_VCAP_Human	1.19123117
65	FUS_26573619_Chip-Seq_HEK293_Human	1.18305142
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17325100
67	TP53_16413492_ChIP-PET_HCT116_Human	1.16968859
68	STAT1_17558387_ChIP-Seq_HELA_Human	1.16073314
69	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15644511
70	AR_19668381_ChIP-Seq_PC3_Human	1.13989881
71	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13544570
72	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.13214888
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11923720
74	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09103425
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08994662
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08943293
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08921466
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08699881
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.06851035
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06490014
81	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.06365167
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06175589
83	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05135946
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04360579
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03059684
86	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02248590
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02027145
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01696518
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01681403
90	RXR_22108803_ChIP-Seq_LS180_Human	0.99451511
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99140839
92	RAC3_21632823_ChIP-Seq_H3396_Human	0.98886061
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98443148
94	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.97561923
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97345492
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95625278
97	SPI1_20517297_ChIP-Seq_HL60_Human	0.95547448
98	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94410588
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94182169
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93495674

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	8.99178770
2	MP0003136_yellow_coat_color	7.64319008
3	MP0005171_absent_coat_pigmentation	6.57031688
4	MP0002653_abnormal_ependyma_morphology	5.92071024
5	MP0003646_muscle_fatigue	4.33551748
6	MP0003045_fibrosis	4.07276451
7	MP0003890_abnormal_embryonic-extraembry	3.77586162
8	MP0003303_peritoneal_inflammation	3.61139175
9	MP0003879_abnormal_hair_cell	3.55594231
10	MP0004147_increased_porphyrin_level	3.15228191
11	MP0004381_abnormal_hair_follicle	2.93983014
12	MP0000569_abnormal_digit_pigmentation	2.60060505
13	MP0002138_abnormal_hepatobiliary_system	2.53906457
14	MP0005075_abnormal_melanosome_morpholog	2.29907659
15	MP0002160_abnormal_reproductive_system	2.10291968
16	MP0006292_abnormal_olfactory_placode	2.08176317
17	MP0002938_white_spotting	1.97660856
18	MP0002168_other_aberrant_phenotype	1.80923660
19	MP0005670_abnormal_white_adipose	1.76652504
20	MP0005085_abnormal_gallbladder_physiolo	1.76339722
21	MP0003705_abnormal_hypodermis_morpholog	1.53841034
22	MP0005365_abnormal_bile_salt	1.53250563
23	MP0000749_muscle_degeneration	1.39036927
24	MP0008789_abnormal_olfactory_epithelium	1.31247431
25	MP0002095_abnormal_skin_pigmentation	1.27271295
26	MP0010352_gastrointestinal_tract_polyps	1.23700942
27	MP0005174_abnormal_tail_pigmentation	1.20254958
28	MP0002234_abnormal_pharynx_morphology	1.19760290
29	MP0006054_spinal_hemorrhage	1.18725009
30	MP0002075_abnormal_coat/hair_pigmentati	1.14678586
31	MP0003195_calcinosis	1.13215292
32	MP0005389_reproductive_system_phenotype	1.07058847
33	MP0002735_abnormal_chemical_nociception	0.98713577
34	MP0005395_other_phenotype	0.95545141
35	MP0000015_abnormal_ear_pigmentation	0.95194012
36	MP0003137_abnormal_impulse_conducting	0.95022117
37	MP0005499_abnormal_olfactory_system	0.89473790
38	MP0005394_taste/olfaction_phenotype	0.89473790
39	MP0001986_abnormal_taste_sensitivity	0.87727088
40	MP0004233_abnormal_muscle_weight	0.85725158
41	MP0001501_abnormal_sleep_pattern	0.84188581
42	MP0001186_pigmentation_phenotype	0.74636030
43	MP0002277_abnormal_respiratory_mucosa	0.73037825
44	MP0004043_abnormal_pH_regulation	0.72425928
45	MP0003252_abnormal_bile_duct	0.70691064
46	MP0002332_abnormal_exercise_endurance	0.70193016
47	MP0000427_abnormal_hair_cycle	0.69428406
48	MP0001486_abnormal_startle_reflex	0.68432049
49	MP0005377_hearing/vestibular/ear_phenot	0.68210908
50	MP0003878_abnormal_ear_physiology	0.68210908
51	MP0000026_abnormal_inner_ear	0.67146677
52	MP0000678_abnormal_parathyroid_gland	0.63895384
53	MP0002254_reproductive_system_inflammat	0.63622007
54	MP0002269_muscular_atrophy	0.63409128
55	MP0005330_cardiomyopathy	0.61997961
56	MP0001324_abnormal_eye_pigmentation	0.61846325
57	MP0005220_abnormal_exocrine_pancreas	0.58197890
58	MP0005535_abnormal_body_temperature	0.53305826
59	MP0003300_gastrointestinal_ulcer	0.51546097
60	MP0002272_abnormal_nervous_system	0.51483687
61	MP0001968_abnormal_touch/_nociception	0.50102394
62	MP0001984_abnormal_olfaction	0.48044918
63	MP0002229_neurodegeneration	0.47682211
64	MP0001963_abnormal_hearing_physiology	0.46883789
65	MP0003183_abnormal_peptide_metabolism	0.46698443
66	MP0008875_abnormal_xenobiotic_pharmacok	0.44157532
67	MP0009115_abnormal_fat_cell	0.43855058
68	MP0005551_abnormal_eye_electrophysiolog	0.43191367
69	MP0004130_abnormal_muscle_cell	0.42672038
70	MP0005410_abnormal_fertilization	0.42495969
71	MP0001851_eye_inflammation	0.42349927
72	MP0001970_abnormal_pain_threshold	0.42295090
73	MP0005319_abnormal_enzyme/_coenzyme	0.42254372
74	MP0000372_irregular_coat_pigmentation	0.41984394
75	MP0006276_abnormal_autonomic_nervous	0.41561890
76	MP0000534_abnormal_ureter_morphology	0.41549445
77	MP0002638_abnormal_pupillary_reflex	0.41015989
78	MP0002876_abnormal_thyroid_physiology	0.40543961
79	MP0001764_abnormal_homeostasis	0.39837217
80	MP0008770_decreased_survivor_rate	0.39597655
81	MP0002733_abnormal_thermal_nociception	0.39545757
82	MP0009764_decreased_sensitivity_to	0.37593940
83	MP0002971_abnormal_brown_adipose	0.37458392
84	MP0009046_muscle_twitch	0.35221237
85	MP0003937_abnormal_limbs/digits/tail_de	0.34942044
86	MP0004142_abnormal_muscle_tone	0.34391873
87	MP0009745_abnormal_behavioral_response	0.34374530
88	MP0005646_abnormal_pituitary_gland	0.33383423
89	MP0000778_abnormal_nervous_system	0.32740233
90	MP0004885_abnormal_endolymph	0.32369507
91	MP0000681_abnormal_thyroid_gland	0.31899289
92	MP0008872_abnormal_physiological_respon	0.30359798
93	MP0000470_abnormal_stomach_morphology	0.30215780
94	MP0000566_synostosis	0.29924258
95	MP0005266_abnormal_metabolism	0.29800249
96	MP0001663_abnormal_digestive_system	0.28801295
97	MP0005448_abnormal_energy_balance	0.28086804
98	MP0002064_seizures	0.27128714
99	MP0004484_altered_response_of	0.26495537
100	MP0008874_decreased_physiological_sensi	0.26258049

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.07912726
2	Amelogenesis imperfecta (HP:0000705)	8.90189919
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.83714974
4	Acanthocytosis (HP:0001927)	6.76283113
5	Parakeratosis (HP:0001036)	6.09260245
6	Aplastic anemia (HP:0001915)	5.31331162
7	Dialeptic seizures (HP:0011146)	5.12316916
8	Colon cancer (HP:0003003)	4.36761449
9	Focal seizures (HP:0007359)	4.07265170
10	Pancreatic cysts (HP:0001737)	3.98731867
11	Proximal amyotrophy (HP:0007126)	3.82820294
12	Hematochezia (HP:0002573)	3.76231659
13	Rectal prolapse (HP:0002035)	3.69986741
14	Congenital ichthyosiform erythroderma (HP:0007431)	3.68761211
15	Vertebral arch anomaly (HP:0008438)	3.66408929
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.62031962
17	Erythroderma (HP:0001019)	3.53309234
18	Spontaneous hematomas (HP:0007420)	3.51293243
19	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.36764153
20	Difficulty walking (HP:0002355)	3.28068718
21	Scapular winging (HP:0003691)	3.21147388
22	Overlapping toe (HP:0001845)	3.06115123
23	Broad ribs (HP:0000885)	2.99853907
24	Conjunctival telangiectasia (HP:0000524)	2.91254934
25	Nephronophthisis (HP:0000090)	2.84919408
26	Abnormality of the renal medulla (HP:0100957)	2.83422166
27	Asymmetric septal hypertrophy (HP:0001670)	2.80713457
28	Poor head control (HP:0002421)	2.73953007
29	Pendular nystagmus (HP:0012043)	2.73340102
30	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.69795404
31	Poikilocytosis (HP:0004447)	2.69786394
32	Enlarged kidneys (HP:0000105)	2.69186271
33	Follicular hyperkeratosis (HP:0007502)	2.68100333
34	Facial shape deformation (HP:0011334)	2.67783187
35	Potter facies (HP:0002009)	2.67783187
36	Abnormality of the renal cortex (HP:0011035)	2.65121426
37	Radial bowing (HP:0002986)	2.59649508
38	Atonic seizures (HP:0010819)	2.59473431
39	Tubular atrophy (HP:0000092)	2.51382951
40	Decreased circulating renin level (HP:0003351)	2.51293655
41	Bilateral sensorineural hearing impairment (HP:0008619)	2.49544439
42	Esophageal varix (HP:0002040)	2.48866505
43	Synostosis of carpal bones (HP:0005048)	2.45107620
44	Absence seizures (HP:0002121)	2.44555049
45	Ulnar claw (HP:0001178)	2.43240988
46	Gangrene (HP:0100758)	2.38896411
47	Chronic hepatic failure (HP:0100626)	2.36356845
48	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.34811429
49	Albinism (HP:0001022)	2.34731159
50	Abnormality of macular pigmentation (HP:0008002)	2.33379220
51	Ulnar bowing (HP:0003031)	2.33142728
52	Thickened calvaria (HP:0002684)	2.25619303
53	Portal hypertension (HP:0001409)	2.23103866
54	Cystic liver disease (HP:0006706)	2.20597254
55	Severe visual impairment (HP:0001141)	2.20295699
56	Type I transferrin isoform profile (HP:0003642)	2.19375649
57	Hypoplastic iliac wings (HP:0002866)	2.18835785
58	Congenital stationary night blindness (HP:0007642)	2.06744727
59	Hypokalemia (HP:0002900)	2.06400123
60	Stomach cancer (HP:0012126)	2.05306424
61	Abnormality of the vocal cords (HP:0008777)	2.04176764
62	IgM deficiency (HP:0002850)	2.02492114
63	Abnormality of the hepatic vasculature (HP:0006707)	2.01861086
64	Retinitis pigmentosa (HP:0000510)	2.01269860
65	3-Methylglutaconic aciduria (HP:0003535)	1.95997896
66	Cerebellar dysplasia (HP:0007033)	1.95062102
67	Dehydration (HP:0001944)	1.92872633
68	2-3 toe syndactyly (HP:0004691)	1.88542702
69	Progressive inability to walk (HP:0002505)	1.87615192
70	Abnormality of the shoulder girdle musculature (HP:0001435)	1.86859145
71	Pancreatic fibrosis (HP:0100732)	1.85737932
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84107822
73	Absent/shortened dynein arms (HP:0200106)	1.84107822
74	Tarsal synostosis (HP:0008368)	1.83885690
75	Abnormality of potassium homeostasis (HP:0011042)	1.83841134
76	Abnormality of alanine metabolism (HP:0010916)	1.83556727
77	Hyperalaninemia (HP:0003348)	1.83556727
78	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.83556727
79	Carpal bone hypoplasia (HP:0001498)	1.83261464
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83072913
81	Abnormal albumin level (HP:0012116)	1.80614015
82	Hypoalbuminemia (HP:0003073)	1.80614015
83	Vertebral fusion (HP:0002948)	1.80173112
84	Recurrent sinusitis (HP:0011108)	1.79041775
85	Petechiae (HP:0000967)	1.78164702
86	True hermaphroditism (HP:0010459)	1.77881368
87	Abnormal drinking behavior (HP:0030082)	1.76833560
88	Polydipsia (HP:0001959)	1.76833560
89	Aortic valve stenosis (HP:0001650)	1.71937818
90	Anencephaly (HP:0002323)	1.70923333
91	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.69651439
92	Visceral angiomatosis (HP:0100761)	1.66705426
93	Lack of skin elasticity (HP:0100679)	1.64799273
94	Synostosis involving bones of the feet (HP:0009140)	1.61078934
95	Synostosis involving bones of the lower limbs (HP:0009138)	1.61078934
96	Abnormality of the fingertips (HP:0001211)	1.61069445
97	Eosinophilia (HP:0001880)	1.59053165
98	Pancytopenia (HP:0001876)	1.59033672
99	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.58371641
100	Everted lower lip vermilion (HP:0000232)	1.57926641

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	6.24542752
2	LATS2	5.65529187
3	PRKD3	3.25079294
4	TESK2	3.17178486
5	CDK19	2.51388654
6	ZAK	2.44736838
7	STK3	2.39832253
8	ACVR1B	2.14840610
9	NLK	2.10989161
10	FRK	2.08118542
11	STK38	2.01953135
12	LATS1	11.6886671
13	MAP2K2	1.96552429
14	MELK	1.54755327
15	NUAK1	1.32401083
16	ERN1	1.12941130
17	BMPR1B	1.07949847
18	GRK7	1.07057798
19	TGFBR2	1.00795123
20	MAP4K2	0.97190891
21	PDPK1	0.81326846
22	MOS	0.80639936
23	PIK3CG	0.80158170
24	PRKAA2	0.78207438
25	PINK1	0.76301687
26	MAP3K2	0.73522057
27	GRK5	0.70328539
28	NEK2	0.67308168
29	ADRBK2	0.58704100
30	ADRBK1	0.58691905
31	KSR2	0.58596022
32	TLK1	0.58296912
33	IRAK3	0.57570900
34	EIF2AK3	0.57465649
35	TAF1	0.57445631
36	TGFBR1	0.53155284
37	PRKD1	0.48018182
38	PRKCI	0.40943165
39	MAP2K3	0.39134160
40	DAPK2	0.38683374
41	WNK4	0.38239264
42	STK10	0.36961892
43	CSNK1A1L	0.35962025
44	STK11	0.35344255
45	PIM1	0.35321729
46	CDK3	0.32876449
47	TNK2	0.32370103
48	PLK2	0.29438189
49	MAPK4	0.28258254
50	PIM2	0.28036735
51	ARAF	0.27159284
52	CHEK2	0.24304475
53	TEC	0.23946681
54	MAP2K6	0.19926365
55	MAP2K1	0.19501326
56	MAP3K1	0.18685714
57	TTK	0.18576851
58	TXK	0.17228742
59	PRKCE	0.16930192
60	EPHA4	0.15766277
61	TAOK3	0.14311140
62	PLK1	0.12309291
63	PLK4	0.11210671
64	NME1	0.10611431
65	NEK9	0.10209636
66	BRAF	0.10145512
67	AKT2	0.10032061
68	CSNK1D	0.08698745
69	ITK	0.08617081
70	MAPK7	0.08332465
71	PTK2B	0.07403742
72	IRAK1	0.06713131
73	MARK3	0.06687536
74	MAPK8	0.06580082
75	MAPK3	0.05060924
76	IKBKB	0.04939907
77	ABL1	0.04805988
78	OXSR1	0.04596778
79	PRKACA	0.03510153
80	AKT1	0.03292844
81	ATR	0.02798016
82	BMX	0.02795170
83	PRKCH	0.02250049
84	BRSK2	0.02144595
85	STK24	0.02004264
86	GRK1	0.01260384
87	CAMK2A	0.00847734
88	CSNK1A1	0.00352693
89	PAK1	0.00282381
90	PRKG2	-0.0426104
91	PDK1	-0.0365548
92	AKT3	-0.0337159
93	GSK3B	-0.0265902
94	FER	-0.0245884
95	JAK2	-0.0224240
96	MAPK13	-0.0150278
97	CAMK2B	-0.0150144
98	CHUK	-0.0142563
99	EIF2AK2	-0.0097672
100	MAPK1	-0.0050068

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.28012926
2	Phototransduction_Homo sapiens_hsa04744	4.85503490
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.15397945
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.37977953
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.34079233
6	Nicotine addiction_Homo sapiens_hsa05033	2.57696514
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.48742522
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.45454231
9	Taste transduction_Homo sapiens_hsa04742	2.18068068
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.10414314
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.05942010
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85073252
13	Morphine addiction_Homo sapiens_hsa05032	1.58748733
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54523906
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.36752477
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.34315536
17	Asthma_Homo sapiens_hsa05310	1.33845860
18	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.31584117
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.24575779
20	VEGF signaling pathway_Homo sapiens_hsa04370	1.23502261
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20574413
22	Viral myocarditis_Homo sapiens_hsa05416	1.19920653
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.10035040
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07251770
25	Histidine metabolism_Homo sapiens_hsa00340	1.05595546
26	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.02804286
27	GABAergic synapse_Homo sapiens_hsa04727	1.00710634
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98852928
29	Homologous recombination_Homo sapiens_hsa03440	0.97333829
30	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.96263818
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95182525
32	Tyrosine metabolism_Homo sapiens_hsa00350	0.92192567
33	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90882697
34	Serotonergic synapse_Homo sapiens_hsa04726	0.86077742
35	Basal transcription factors_Homo sapiens_hsa03022	0.85670283
36	One carbon pool by folate_Homo sapiens_hsa00670	0.85415843
37	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84901276
38	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.80436481
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.78466050
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77432924
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74690547
42	Lysine degradation_Homo sapiens_hsa00310	0.73603028
43	ABC transporters_Homo sapiens_hsa02010	0.72722237
44	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.71709067
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70566005
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70027961
47	Salivary secretion_Homo sapiens_hsa04970	0.69124086
48	Butanoate metabolism_Homo sapiens_hsa00650	0.63962174
49	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.61109319
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60043160
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57766328
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.54866717
53	Bile secretion_Homo sapiens_hsa04976	0.54653655
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52882733
55	ECM-receptor interaction_Homo sapiens_hsa04512	0.51879043
56	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51247135
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50691494
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50257869
59	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50136950
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49703429
61	Tuberculosis_Homo sapiens_hsa05152	0.49534447
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49398684
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48474206
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.47934629
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47226694
66	Olfactory transduction_Homo sapiens_hsa04740	0.45606712
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.45195688
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45083771
69	Fatty acid degradation_Homo sapiens_hsa00071	0.44557629
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41729299
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.41236452
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.37119460
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.37058013
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35668451
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34637881
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32490421
77	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32299674
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.32211008
79	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.32174589
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.28927557
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.28682973
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28529925
83	Circadian entrainment_Homo sapiens_hsa04713	0.27759560
84	Allograft rejection_Homo sapiens_hsa05330	0.26908616
85	African trypanosomiasis_Homo sapiens_hsa05143	0.25566397
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.24692224
87	Retinol metabolism_Homo sapiens_hsa00830	0.24620189
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23299218
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20934203
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.20682109
91	Colorectal cancer_Homo sapiens_hsa05210	0.20575288
92	Long-term depression_Homo sapiens_hsa04730	0.19639468
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.17551237
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.16902568
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.16838296
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.16758448
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.14591891
98	Melanoma_Homo sapiens_hsa05218	0.14257373
99	Metabolic pathways_Homo sapiens_hsa01100	0.13801038
100	Insulin secretion_Homo sapiens_hsa04911	0.12002672

RPS15AP36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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