RPS15AP38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.94180718
2translational termination (GO:0006415)7.62233089
3ribosomal small subunit biogenesis (GO:0042274)7.57837812
4ribosomal small subunit assembly (GO:0000028)7.41706529
5maturation of SSU-rRNA (GO:0030490)6.94279915
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.14990720
7cotranslational protein targeting to membrane (GO:0006613)6.09687534
8translational elongation (GO:0006414)6.08000223
9protein targeting to ER (GO:0045047)6.05422617
10cellular protein complex disassembly (GO:0043624)5.85241555
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82103426
12viral life cycle (GO:0019058)5.73384796
13protein localization to endoplasmic reticulum (GO:0070972)5.68314674
14substrate-independent telencephalic tangential migration (GO:0021826)5.59998888
15substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.59998888
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.55991229
17protein complex disassembly (GO:0043241)5.13783076
18cell proliferation in forebrain (GO:0021846)5.08831325
19behavioral response to nicotine (GO:0035095)4.93639119
20macromolecular complex disassembly (GO:0032984)4.84441221
21translational initiation (GO:0006413)4.58131007
22pyrimidine nucleobase catabolic process (GO:0006208)4.52119073
23protein targeting to membrane (GO:0006612)4.25063323
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.13902489
25protein neddylation (GO:0045116)3.99568682
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.80123230
27tongue development (GO:0043586)3.76534251
28chaperone-mediated protein transport (GO:0072321)3.75133034
29nuclear-transcribed mRNA catabolic process (GO:0000956)3.67331925
30pattern specification involved in kidney development (GO:0061004)3.64383788
31hypothalamus development (GO:0021854)3.64362163
32positive regulation of T cell apoptotic process (GO:0070234)3.60749334
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60223285
34nonmotile primary cilium assembly (GO:0035058)3.59018846
35ribosomal large subunit biogenesis (GO:0042273)3.53883188
36spinal cord association neuron differentiation (GO:0021527)3.52090501
37ATP synthesis coupled proton transport (GO:0015986)3.51562512
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51562512
39nucleobase catabolic process (GO:0046113)3.50319070
40mRNA catabolic process (GO:0006402)3.47124960
41axonal fasciculation (GO:0007413)3.44036471
42short-term memory (GO:0007614)3.43413525
43axon ensheathment in central nervous system (GO:0032291)3.42755167
44central nervous system myelination (GO:0022010)3.42755167
45neuron fate determination (GO:0048664)3.35943436
46somite development (GO:0061053)3.27010787
47translation (GO:0006412)3.21339175
48epithelial cilium movement (GO:0003351)3.17347109
49auditory receptor cell differentiation (GO:0042491)3.15991670
50neuron recognition (GO:0008038)3.11895129
51body morphogenesis (GO:0010171)3.11042362
52head development (GO:0060322)3.10941171
53RNA catabolic process (GO:0006401)3.09626067
54cerebral cortex radially oriented cell migration (GO:0021799)3.09045438
55forebrain neuron differentiation (GO:0021879)3.07758620
56telencephalon development (GO:0021537)3.06321426
57negative regulation of response to food (GO:0032096)3.04537026
58negative regulation of appetite (GO:0032099)3.04537026
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04400885
60positive regulation of respiratory burst (GO:0060267)2.99095261
61regulation of cilium movement (GO:0003352)2.94962810
62establishment of protein localization to membrane (GO:0090150)2.94949955
63postsynaptic membrane organization (GO:0001941)2.93830200
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92309317
65axonemal dynein complex assembly (GO:0070286)2.88665218
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88482009
67establishment of mitochondrion localization (GO:0051654)2.88249956
68limb development (GO:0060173)2.86729588
69appendage development (GO:0048736)2.86729588
70ribonucleoprotein complex biogenesis (GO:0022613)2.86110164
71cardiovascular system development (GO:0072358)2.85779533
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84977621
73intraciliary transport (GO:0042073)2.84484728
74spinal cord development (GO:0021510)2.83691136
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.82297153
76NADH dehydrogenase complex assembly (GO:0010257)2.82297153
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82297153
78segment specification (GO:0007379)2.80538170
79protein complex biogenesis (GO:0070271)2.79164920
80transmission of nerve impulse (GO:0019226)2.79082182
81cellular component biogenesis (GO:0044085)2.78194133
82regulation of microtubule-based movement (GO:0060632)2.76805192
83camera-type eye morphogenesis (GO:0048593)2.76443177
84genetic imprinting (GO:0071514)2.75438062
85neuronal stem cell maintenance (GO:0097150)2.75189652
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74282669
87protein targeting (GO:0006605)2.70867267
88dendritic spine morphogenesis (GO:0060997)2.70061668
89olfactory bulb development (GO:0021772)2.69469731
90embryonic body morphogenesis (GO:0010172)2.68550593
91dentate gyrus development (GO:0021542)2.68339368
92axon extension (GO:0048675)2.67691987
93pyrimidine nucleotide catabolic process (GO:0006244)2.67336067
94positive regulation of gastrulation (GO:2000543)2.67173027
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66899840
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63805511
97neurofilament cytoskeleton organization (GO:0060052)2.62305269
98positive regulation of lymphocyte apoptotic process (GO:0070230)2.62199046
99retinal ganglion cell axon guidance (GO:0031290)2.62034675
100cell migration in hindbrain (GO:0021535)2.61898056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.55023813
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.18717706
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.57943702
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.55940565
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54064338
6EZH2_27294783_Chip-Seq_ESCs_Mouse2.39337222
7SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35041328
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22012458
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.19587884
10REST_21632747_ChIP-Seq_MESCs_Mouse2.17164172
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.14402600
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.04731522
13RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99334988
14RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97738410
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.97428820
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97016865
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91816751
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91816751
19REST_18959480_ChIP-ChIP_MESCs_Mouse1.83212333
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81998141
21IRF1_19129219_ChIP-ChIP_H3396_Human1.78007835
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77518678
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71380026
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69177748
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68657954
26TP53_20018659_ChIP-ChIP_R1E_Mouse1.65375193
27CTCF_27219007_Chip-Seq_Bcells_Human1.64169570
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61251129
29SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.59636896
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55529898
31OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.55074031
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.53043781
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52948748
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.47747993
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.46894959
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46306858
37RNF2_27304074_Chip-Seq_NSC_Mouse1.45546063
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45210702
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43097381
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42612087
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35572406
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31428415
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29823517
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.28628989
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26412402
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25066338
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21738367
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21108178
49VDR_22108803_ChIP-Seq_LS180_Human1.20898162
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19494307
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18046457
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17515034
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14420921
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12936907
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08847399
56XRN2_22483619_ChIP-Seq_HELA_Human1.08633964
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08265209
58ZNF274_21170338_ChIP-Seq_K562_Hela1.08217874
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07926619
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.06773759
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06303377
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03207722
63ERA_21632823_ChIP-Seq_H3396_Human1.01738861
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00179614
65MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99983235
66P68_20966046_ChIP-Seq_HELA_Human0.99811101
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99296964
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99003743
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98230264
70NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97310549
71DROSHA_22980978_ChIP-Seq_HELA_Human0.96953010
72RING1B_27294783_Chip-Seq_NPCs_Mouse0.96814867
73OCT4_19829295_ChIP-Seq_ESCs_Human0.96532492
74NANOG_20526341_ChIP-Seq_ESCs_Human0.96414503
75TTF2_22483619_ChIP-Seq_HELA_Human0.96104711
76FOXP1_21924763_ChIP-Seq_HESCs_Human0.95011505
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94192315
78CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93412782
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.93314059
80SA1_27219007_Chip-Seq_Bcells_Human0.92894395
81TAF2_19829295_ChIP-Seq_ESCs_Human0.92348540
82MYC_18940864_ChIP-ChIP_HL60_Human0.91103914
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90691193
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90406340
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.90275551
86MYC_18555785_ChIP-Seq_MESCs_Mouse0.87908272
87E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87771624
88SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86419120
89CTCF_20526341_ChIP-Seq_ESCs_Human0.86289514
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85960895
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.85810277
92THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85677201
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.85268647
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.84492121
95P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83623687
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82950610
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82333291
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82333291
99BCL6_27268052_Chip-Seq_Bcells_Human0.81919618
100KDM2B_26808549_Chip-Seq_K562_Human0.81469901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.09234228
2MP0006292_abnormal_olfactory_placode5.27386163
3MP0003787_abnormal_imprinting3.82140023
4MP0002653_abnormal_ependyma_morphology3.33809348
5MP0003123_paternal_imprinting3.28787807
6MP0003122_maternal_imprinting3.01680516
7MP0008789_abnormal_olfactory_epithelium2.84202456
8MP0005499_abnormal_olfactory_system2.61130993
9MP0005394_taste/olfaction_phenotype2.61130993
10MP0000778_abnormal_nervous_system2.59105787
11MP0003121_genomic_imprinting2.46470789
12MP0002163_abnormal_gland_morphology2.23974368
13MP0001293_anophthalmia2.11136998
14MP0006276_abnormal_autonomic_nervous2.04585732
15MP0003136_yellow_coat_color2.02092856
16MP0003878_abnormal_ear_physiology1.98548635
17MP0005377_hearing/vestibular/ear_phenot1.98548635
18MP0004142_abnormal_muscle_tone1.94581015
19MP0003880_abnormal_central_pattern1.84577586
20MP0010030_abnormal_orbit_morphology1.77442392
21MP0003646_muscle_fatigue1.71805162
22MP0005423_abnormal_somatic_nervous1.68431010
23MP0001485_abnormal_pinna_reflex1.66307352
24MP0008877_abnormal_DNA_methylation1.65739693
25MP0002638_abnormal_pupillary_reflex1.53242337
26MP0000049_abnormal_middle_ear1.52370700
27MP0004133_heterotaxia1.50942364
28MP0004885_abnormal_endolymph1.50000880
29MP0000955_abnormal_spinal_cord1.46905752
30MP0002272_abnormal_nervous_system1.46719534
31MP0004859_abnormal_synaptic_plasticity1.40954981
32MP0002557_abnormal_social/conspecific_i1.40876436
33MP0002184_abnormal_innervation1.40493370
34MP0002938_white_spotting1.38847058
35MP0000631_abnormal_neuroendocrine_gland1.36795319
36MP0002837_dystrophic_cardiac_calcinosis1.31307045
37MP0001984_abnormal_olfaction1.30654262
38MP0003890_abnormal_embryonic-extraembry1.30602546
39MP0003879_abnormal_hair_cell1.30580838
40MP0003942_abnormal_urinary_system1.28286615
41MP0002752_abnormal_somatic_nervous1.27352526
42MP0002733_abnormal_thermal_nociception1.27266386
43MP0005195_abnormal_posterior_eye1.26859466
44MP0002063_abnormal_learning/memory/cond1.23102176
45MP0004742_abnormal_vestibular_system1.21322592
46MP0003635_abnormal_synaptic_transmissio1.19991430
47MP0001529_abnormal_vocalization1.19245393
48MP0001188_hyperpigmentation1.18427657
49MP0001970_abnormal_pain_threshold1.17739104
50MP0000566_synostosis1.17091097
51MP0000026_abnormal_inner_ear1.16838319
52MP0001968_abnormal_touch/_nociception1.16059115
53MP0001286_abnormal_eye_development1.13433051
54MP0005551_abnormal_eye_electrophysiolog1.12748370
55MP0002160_abnormal_reproductive_system1.11459417
56MP0002572_abnormal_emotion/affect_behav1.10947422
57MP0009053_abnormal_anal_canal1.09207986
58MP0002882_abnormal_neuron_morphology1.09135295
59MP0002233_abnormal_nose_morphology1.07585660
60MP0001440_abnormal_grooming_behavior1.07345874
61MP0005379_endocrine/exocrine_gland_phen1.07063841
62MP0009745_abnormal_behavioral_response1.06624880
63MP0003938_abnormal_ear_development1.06454099
64MP0002152_abnormal_brain_morphology1.04725518
65MP0003861_abnormal_nervous_system1.04175457
66MP0002095_abnormal_skin_pigmentation1.03460817
67MP0002734_abnormal_mechanical_nocicepti1.03397493
68MP0001905_abnormal_dopamine_level0.98533636
69MP0005174_abnormal_tail_pigmentation0.97894760
70MP0004145_abnormal_muscle_electrophysio0.96472400
71MP0002736_abnormal_nociception_after0.96317537
72MP0003755_abnormal_palate_morphology0.95950374
73MP0001348_abnormal_lacrimal_gland0.94276408
74MP0006072_abnormal_retinal_apoptosis0.94083516
75MP0002067_abnormal_sensory_capabilities0.92274580
76MP0005646_abnormal_pituitary_gland0.91289298
77MP0001486_abnormal_startle_reflex0.90941869
78MP0001963_abnormal_hearing_physiology0.89541345
79MP0002822_catalepsy0.88382977
80MP0001502_abnormal_circadian_rhythm0.88076344
81MP0008775_abnormal_heart_ventricle0.86905852
82MP0003937_abnormal_limbs/digits/tail_de0.84257450
83MP0001986_abnormal_taste_sensitivity0.83840963
84MP0005389_reproductive_system_phenotype0.83801200
85MP0004811_abnormal_neuron_physiology0.83531671
86MP0002697_abnormal_eye_size0.82457751
87MP0002102_abnormal_ear_morphology0.81133726
88MP0003011_delayed_dark_adaptation0.79048455
89MP0004130_abnormal_muscle_cell0.76387478
90MP0009046_muscle_twitch0.75855392
91MP0002092_abnormal_eye_morphology0.75717866
92MP0002116_abnormal_craniofacial_bone0.75063728
93MP0005084_abnormal_gallbladder_morpholo0.73750680
94MP0002876_abnormal_thyroid_physiology0.72053293
95MP0001919_abnormal_reproductive_system0.71986053
96MP0002064_seizures0.71213747
97MP0005391_vision/eye_phenotype0.71050449
98MP0000534_abnormal_ureter_morphology0.70892993
99MP0002210_abnormal_sex_determination0.70811083
100MP0003315_abnormal_perineum_morphology0.70266560

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.18228676
2Abnormality of cells of the erythroid lineage (HP:0012130)4.86306050
3Septo-optic dysplasia (HP:0100842)4.01237762
4Molar tooth sign on MRI (HP:0002419)3.78832222
5Abnormality of midbrain morphology (HP:0002418)3.78832222
6Macrocytic anemia (HP:0001972)3.78763618
7Rib fusion (HP:0000902)3.70294156
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.63202442
9Myokymia (HP:0002411)3.57985299
10Abnormal number of erythroid precursors (HP:0012131)3.42806780
11Pancreatic fibrosis (HP:0100732)3.39783054
12Acute necrotizing encephalopathy (HP:0006965)3.13977653
13Medial flaring of the eyebrow (HP:0010747)3.13831586
14Pallor (HP:0000980)3.06912592
15Nephronophthisis (HP:0000090)3.04420381
16Colon cancer (HP:0003003)2.91963675
17Adrenal hypoplasia (HP:0000835)2.89857239
18Absent thumb (HP:0009777)2.82201128
1911 pairs of ribs (HP:0000878)2.80228854
20Abnormal mitochondria in muscle tissue (HP:0008316)2.78399938
21Hepatoblastoma (HP:0002884)2.74966663
22Gait imbalance (HP:0002141)2.74465642
23Sclerocornea (HP:0000647)2.63449648
24Partial duplication of thumb phalanx (HP:0009944)2.63369334
25Anophthalmia (HP:0000528)2.62633651
26Acute encephalopathy (HP:0006846)2.61102514
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57578777
28True hermaphroditism (HP:0010459)2.56931164
29Diastasis recti (HP:0001540)2.54785798
30Pancreatic cysts (HP:0001737)2.54562628
31Stenosis of the external auditory canal (HP:0000402)2.52004651
32Congenital primary aphakia (HP:0007707)2.50641289
33Agitation (HP:0000713)2.50448941
34Nephrogenic diabetes insipidus (HP:0009806)2.46327219
35Abnormality of the renal medulla (HP:0100957)2.44904904
36Maternal diabetes (HP:0009800)2.44182695
37Depressed nasal ridge (HP:0000457)2.43169562
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.39793195
39Polyphagia (HP:0002591)2.37903022
40Mitochondrial inheritance (HP:0001427)2.37220384
41Asplenia (HP:0001746)2.36044318
42Progressive macrocephaly (HP:0004481)2.35112021
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.34910222
44Absent/shortened dynein arms (HP:0200106)2.34910222
45Absent septum pellucidum (HP:0001331)2.34690753
46Abnormality of the labia minora (HP:0012880)2.31229590
47Growth hormone deficiency (HP:0000824)2.31075901
48Abnormal rod and cone electroretinograms (HP:0008323)2.30601704
49Hyperthyroidism (HP:0000836)2.29208473
50Optic nerve hypoplasia (HP:0000609)2.28398660
51Abnormality of DNA repair (HP:0003254)2.24257872
52Anencephaly (HP:0002323)2.23468063
53Tubular atrophy (HP:0000092)2.23143281
54Anomalous pulmonary venous return (HP:0010772)2.22533620
55Impulsivity (HP:0100710)2.19308378
56Abnormal pancreas size (HP:0012094)2.19240172
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14588421
58Partial duplication of the phalanx of hand (HP:0009999)2.11780324
59Poor coordination (HP:0002370)2.11354836
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07449398
61Cystic liver disease (HP:0006706)2.06367662
62Missing ribs (HP:0000921)2.04180079
63Type II lissencephaly (HP:0007260)2.02950400
64Oligodactyly (HP:0012165)2.02230460
65Hypoplasia of the radius (HP:0002984)2.01782982
66Abnormal respiratory motile cilium morphology (HP:0005938)1.99556812
67Abnormal respiratory epithelium morphology (HP:0012253)1.99556812
68Abnormality of the 4th metacarpal (HP:0010012)1.98398535
69Oligodactyly (hands) (HP:0001180)1.96546813
70Hip dysplasia (HP:0001385)1.96349932
71Hyperglycinemia (HP:0002154)1.95224295
72Abnormal ciliary motility (HP:0012262)1.94582318
73Increased CSF lactate (HP:0002490)1.94393492
74Hypogonadotrophic hypogonadism (HP:0000044)1.94211065
75Vaginal atresia (HP:0000148)1.93486557
76Deep palmar crease (HP:0006191)1.91227044
77Congenital stationary night blindness (HP:0007642)1.90130582
78Abnormal number of incisors (HP:0011064)1.89408186
79Lissencephaly (HP:0001339)1.88510873
80Chronic hepatic failure (HP:0100626)1.88137312
81Abnormality of the diencephalon (HP:0010662)1.87999160
82Hypoplasia of the ulna (HP:0003022)1.86672248
83Progressive cerebellar ataxia (HP:0002073)1.86359552
84Pachygyria (HP:0001302)1.85912933
85Abnormality of reticulocytes (HP:0004312)1.85766310
86Abnormality of the pulmonary veins (HP:0011718)1.85419495
87Abnormal respiratory motile cilium physiology (HP:0012261)1.84128260
88Supernumerary spleens (HP:0009799)1.83885303
89Postaxial foot polydactyly (HP:0001830)1.83446947
90Holoprosencephaly (HP:0001360)1.82587643
91Genital tract atresia (HP:0001827)1.82495980
92Abnormality of the aortic arch (HP:0012303)1.82241030
93Enlarged kidneys (HP:0000105)1.81996905
94Pendular nystagmus (HP:0012043)1.80128079
95Short 4th metacarpal (HP:0010044)1.79839737
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79839737
97Optic nerve coloboma (HP:0000588)1.78863409
98Optic disc pallor (HP:0000543)1.78822957
99Cerebral edema (HP:0002181)1.78341353
100Narrow forehead (HP:0000341)1.76776298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.15185365
2WNK43.11911322
3CDK192.79736255
4EPHB22.79611221
5DYRK22.73994702
6CDC72.58529417
7PIK3CA2.53141902
8NTRK22.43884115
9TYRO32.39556106
10CASK2.28189813
11MAP3K112.22099903
12MAP3K92.01895719
13PINK11.91298129
14MARK11.82468405
15CAMK1D1.71314553
16CAMK11.68273443
17BRAF1.67722478
18MAP2K71.64933358
19LRRK21.64175868
20EPHA41.61230108
21PRKCG1.54293621
22ADRBK21.53050344
23BCKDK1.51067746
24STK111.49893618
25MINK11.48685666
26MARK21.48336263
27CAMK1G1.40332665
28DYRK1B1.39089277
29NTRK31.34634062
30ARAF1.30643280
31GRK11.17930540
32MAP3K41.17676653
33DMPK1.16487063
34PRKCH1.16308998
35TIE11.11527767
36SGK4941.09341319
37SGK2231.09341319
38STK391.05626930
39TNIK1.04856565
40CAMKK11.04814212
41RPS6KA20.97546941
42NUAK10.95910922
43AURKA0.95443207
44MAPK130.91583606
45BMPR1B0.91377249
46WNK30.91182504
47PAK30.89713302
48DYRK30.89335769
49RPS6KA60.88831897
50PRKCZ0.87818963
51ICK0.84988455
52CAMKK20.83422489
53WNK10.82051847
54LIMK10.79989206
55ABL20.79578885
56RPS6KC10.76521634
57RPS6KL10.76521634
58PRKCQ0.74964200
59DYRK1A0.74398584
60ADRBK10.73466475
61CSNK1E0.73250588
62DAPK30.71726357
63PRKACA0.71691801
64NTRK10.71187187
65PRKCI0.70037443
66MAP2K40.69315811
67CAMK40.67029710
68NEK20.66568297
69PIM20.65443206
70MAPK150.65268408
71SGK10.62046864
72MUSK0.61637746
73SIK20.59815265
74PNCK0.59392008
75NME20.58236686
76CHEK20.57973662
77CSNK2A20.57867751
78CDK50.57839687
79ZAK0.56542421
80SGK20.54681944
81TLK10.54538536
82OXSR10.51447833
83AKT10.50895183
84PLK10.50033370
85FRK0.48955003
86NME10.48575593
87CDK140.46251497
88PRKD30.45319521
89PRKCD0.44894531
90CSNK1A10.44238823
91CDK11A0.43757504
92CSNK1G20.43234558
93RPS6KA30.42181859
94BTK0.41711010
95AURKB0.41538032
96SGK30.41473992
97PRKDC0.41426164
98ERBB20.40798603
99INSRR0.39006106
100PRKCA0.38463387

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.37636677
2Oxidative phosphorylation_Homo sapiens_hsa001903.84824390
3Parkinsons disease_Homo sapiens_hsa050123.38291719
4Cardiac muscle contraction_Homo sapiens_hsa042603.33412369
5Huntingtons disease_Homo sapiens_hsa050162.57783921
6Alzheimers disease_Homo sapiens_hsa050102.32249263
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28672604
8Sulfur relay system_Homo sapiens_hsa041222.27527544
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24125305
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18980627
11Basal cell carcinoma_Homo sapiens_hsa052171.92528383
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92316825
13Nicotine addiction_Homo sapiens_hsa050331.84110800
14Notch signaling pathway_Homo sapiens_hsa043301.72794708
15Phototransduction_Homo sapiens_hsa047441.69836793
16Linoleic acid metabolism_Homo sapiens_hsa005911.61886715
17Hedgehog signaling pathway_Homo sapiens_hsa043401.60315849
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54658172
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53408478
20Axon guidance_Homo sapiens_hsa043601.52572276
21RNA polymerase_Homo sapiens_hsa030201.43380084
22Steroid biosynthesis_Homo sapiens_hsa001001.39871609
23Protein export_Homo sapiens_hsa030601.27655610
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18970747
25Insulin secretion_Homo sapiens_hsa049111.16320015
26Morphine addiction_Homo sapiens_hsa050321.16282512
27Fanconi anemia pathway_Homo sapiens_hsa034601.13507936
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13084132
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09192702
30Glutamatergic synapse_Homo sapiens_hsa047241.02158452
31Butanoate metabolism_Homo sapiens_hsa006500.99700806
32Peroxisome_Homo sapiens_hsa041460.98529557
33Hippo signaling pathway_Homo sapiens_hsa043900.97506889
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97140559
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95120387
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94427921
37RNA degradation_Homo sapiens_hsa030180.93366127
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92874826
39Homologous recombination_Homo sapiens_hsa034400.92784707
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92617920
41GABAergic synapse_Homo sapiens_hsa047270.92203487
42Fat digestion and absorption_Homo sapiens_hsa049750.91438641
43Dopaminergic synapse_Homo sapiens_hsa047280.84693056
44Basal transcription factors_Homo sapiens_hsa030220.84356245
45Olfactory transduction_Homo sapiens_hsa047400.83999228
46Tryptophan metabolism_Homo sapiens_hsa003800.77980160
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75328176
48Cholinergic synapse_Homo sapiens_hsa047250.75054240
49Cocaine addiction_Homo sapiens_hsa050300.72808614
50Synaptic vesicle cycle_Homo sapiens_hsa047210.71151452
51Ether lipid metabolism_Homo sapiens_hsa005650.68208634
52Pyrimidine metabolism_Homo sapiens_hsa002400.67464349
53Arachidonic acid metabolism_Homo sapiens_hsa005900.67371677
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65276601
55Circadian entrainment_Homo sapiens_hsa047130.65053852
56Wnt signaling pathway_Homo sapiens_hsa043100.64604593
57Serotonergic synapse_Homo sapiens_hsa047260.63014505
58Dilated cardiomyopathy_Homo sapiens_hsa054140.62155188
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61941288
60Folate biosynthesis_Homo sapiens_hsa007900.60692338
61Melanogenesis_Homo sapiens_hsa049160.59150770
62Metabolic pathways_Homo sapiens_hsa011000.57924886
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57855826
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56539807
65Collecting duct acid secretion_Homo sapiens_hsa049660.56042160
66Ovarian steroidogenesis_Homo sapiens_hsa049130.55383682
67Oxytocin signaling pathway_Homo sapiens_hsa049210.53546356
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52732756
69Retinol metabolism_Homo sapiens_hsa008300.48150197
70Nucleotide excision repair_Homo sapiens_hsa034200.47284880
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.46027117
72cAMP signaling pathway_Homo sapiens_hsa040240.45963771
73Caffeine metabolism_Homo sapiens_hsa002320.44675409
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43879520
75Fatty acid degradation_Homo sapiens_hsa000710.43447817
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41700504
77Ras signaling pathway_Homo sapiens_hsa040140.39559280
78Pyruvate metabolism_Homo sapiens_hsa006200.39203011
79Glycerolipid metabolism_Homo sapiens_hsa005610.37896976
80Regulation of autophagy_Homo sapiens_hsa041400.37226123
81Chemical carcinogenesis_Homo sapiens_hsa052040.34323411
82beta-Alanine metabolism_Homo sapiens_hsa004100.34270240
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33729509
84Taste transduction_Homo sapiens_hsa047420.33094736
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32999033
86Purine metabolism_Homo sapiens_hsa002300.32114142
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31222701
88Propanoate metabolism_Homo sapiens_hsa006400.30978589
89MAPK signaling pathway_Homo sapiens_hsa040100.30671257
90Nitrogen metabolism_Homo sapiens_hsa009100.30422056
91Thyroid hormone synthesis_Homo sapiens_hsa049180.30416290
92One carbon pool by folate_Homo sapiens_hsa006700.29094273
93Arginine and proline metabolism_Homo sapiens_hsa003300.26848065
94Rap1 signaling pathway_Homo sapiens_hsa040150.26115750
95Melanoma_Homo sapiens_hsa052180.25701753
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.25558836
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24504165
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.24457215
99Alcoholism_Homo sapiens_hsa050340.23444392
100Long-term depression_Homo sapiens_hsa047300.22834342

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