RPS15AP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.01818402
2translational termination (GO:0006415)7.70615619
3ribosomal small subunit assembly (GO:0000028)7.68964279
4ribosomal small subunit biogenesis (GO:0042274)6.68590020
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.39311342
6cotranslational protein targeting to membrane (GO:0006613)6.32041487
7protein targeting to ER (GO:0045047)6.29643742
8translational elongation (GO:0006414)6.22093822
9maturation of SSU-rRNA (GO:0030490)6.09738262
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.07899949
11protein localization to endoplasmic reticulum (GO:0070972)5.91583172
12viral life cycle (GO:0019058)5.85976589
13cellular protein complex disassembly (GO:0043624)5.85094542
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.59371418
15behavioral response to nicotine (GO:0035095)5.36454368
16protein complex disassembly (GO:0043241)5.09439838
17cell proliferation in forebrain (GO:0021846)4.86764361
18macromolecular complex disassembly (GO:0032984)4.85368023
19auditory receptor cell differentiation (GO:0042491)4.77047712
20translational initiation (GO:0006413)4.76066190
21nonmotile primary cilium assembly (GO:0035058)4.43446888
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32958112
23protein targeting to membrane (GO:0006612)4.32464845
24neuron fate determination (GO:0048664)4.19331626
25GTP biosynthetic process (GO:0006183)4.11985245
26ribosomal large subunit biogenesis (GO:0042273)4.11068730
27substrate-independent telencephalic tangential migration (GO:0021826)3.88312418
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.88312418
29central nervous system myelination (GO:0022010)3.81618824
30axon ensheathment in central nervous system (GO:0032291)3.81618824
31nuclear-transcribed mRNA catabolic process (GO:0000956)3.81398586
32pattern specification involved in kidney development (GO:0061004)3.78289789
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74667875
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.74667875
35NADH dehydrogenase complex assembly (GO:0010257)3.74667875
36kidney morphogenesis (GO:0060993)3.70550865
37UTP biosynthetic process (GO:0006228)3.66410535
38protein complex biogenesis (GO:0070271)3.64523502
39translation (GO:0006412)3.63615795
40mRNA catabolic process (GO:0006402)3.63145699
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59344461
42tongue development (GO:0043586)3.54867417
43chaperone-mediated protein transport (GO:0072321)3.53591598
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50301248
45ATP synthesis coupled proton transport (GO:0015986)3.50301248
46cardiovascular system development (GO:0072358)3.42548962
47UTP metabolic process (GO:0046051)3.41759577
48epithelial cilium movement (GO:0003351)3.35721693
49lens fiber cell development (GO:0070307)3.34971969
50pyrimidine nucleotide catabolic process (GO:0006244)3.34665191
51mitochondrial respiratory chain complex assembly (GO:0033108)3.33964763
52base-excision repair, AP site formation (GO:0006285)3.26308134
53RNA catabolic process (GO:0006401)3.22712494
54protein neddylation (GO:0045116)3.19353891
55cellular component biogenesis (GO:0044085)3.18866930
56ribonucleoprotein complex biogenesis (GO:0022613)3.16641394
57regulation of cilium movement (GO:0003352)3.16227360
58neuronal stem cell maintenance (GO:0097150)3.15560657
59CTP biosynthetic process (GO:0006241)3.14353069
60CTP metabolic process (GO:0046036)3.14353069
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12468590
62hypothalamus development (GO:0021854)3.11934506
63telencephalon development (GO:0021537)3.11245732
64dentate gyrus development (GO:0021542)3.09513090
65ubiquinone biosynthetic process (GO:0006744)3.08283647
66positive regulation of T cell apoptotic process (GO:0070234)3.08239753
67intraciliary transport (GO:0042073)3.04127034
68lung epithelium development (GO:0060428)3.03558690
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.98786405
70synaptic transmission, cholinergic (GO:0007271)2.96949478
71establishment of protein localization to membrane (GO:0090150)2.92923316
72axonemal dynein complex assembly (GO:0070286)2.92670544
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92064037
74respiratory tube development (GO:0030323)2.90957879
75pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.86862011
76ubiquinone metabolic process (GO:0006743)2.85949697
77regulation of microtubule-based movement (GO:0060632)2.84964288
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84773143
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84265910
80water-soluble vitamin biosynthetic process (GO:0042364)2.84253208
81metanephric nephron tubule development (GO:0072234)2.84129654
82metanephric tubule development (GO:0072170)2.84129654
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81156819
84segment specification (GO:0007379)2.80748925
85negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.79283915
86radial glial cell differentiation (GO:0060019)2.78742335
87negative regulation of response to food (GO:0032096)2.73801035
88negative regulation of appetite (GO:0032099)2.73801035
89pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.72884912
90replication fork processing (GO:0031297)2.72270212
91protein polyglutamylation (GO:0018095)2.71871669
92protein targeting (GO:0006605)2.70158463
93lung-associated mesenchyme development (GO:0060484)2.68910548
94somite development (GO:0061053)2.68579901
95negative regulation of oligodendrocyte differentiation (GO:0048715)2.64501435
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.62700257
97establishment of protein localization to organelle (GO:0072594)2.62135025
98positive regulation of gastrulation (GO:2000543)2.61774480
99head development (GO:0060322)2.59668304
100axoneme assembly (GO:0035082)2.59491430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99398346
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.80948595
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.01670070
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79868593
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69587187
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53975811
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.42843378
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.37278380
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.25320003
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21020675
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.14908030
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.08596449
13ZNF274_21170338_ChIP-Seq_K562_Hela2.05239102
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96577147
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95453353
16VDR_22108803_ChIP-Seq_LS180_Human1.89343217
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87867749
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81685409
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.80250485
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76860669
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.73761905
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72329956
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71980196
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.70526208
25REST_21632747_ChIP-Seq_MESCs_Mouse1.70497496
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66995580
27SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.64395588
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63616132
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.61990168
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.60306637
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.57951841
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57184819
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57184819
34IRF1_19129219_ChIP-ChIP_H3396_Human1.50553767
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.49008646
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48528254
37TTF2_22483619_ChIP-Seq_HELA_Human1.46536098
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44090199
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40952708
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40593274
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.38189643
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38133640
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.36230955
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34646095
45MYC_18940864_ChIP-ChIP_HL60_Human1.28433850
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27397646
47ERA_21632823_ChIP-Seq_H3396_Human1.26764758
48XRN2_22483619_ChIP-Seq_HELA_Human1.26484399
49NANOG_20526341_ChIP-Seq_ESCs_Human1.24574713
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23977041
51RNF2_27304074_Chip-Seq_NSC_Mouse1.23749646
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23419675
53CTCF_27219007_Chip-Seq_Bcells_Human1.22750241
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21803206
55TP53_22573176_ChIP-Seq_HFKS_Human1.19832009
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19400514
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17985883
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17870559
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.17284113
60TAF2_19829295_ChIP-Seq_ESCs_Human1.16187465
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15242070
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.12912034
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12246405
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12224863
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09845973
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08617926
67FOXP3_21729870_ChIP-Seq_TREG_Human1.07749923
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07377111
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06855751
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06137110
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05960798
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03521537
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03292582
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.02892712
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02019419
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01510794
77SA1_27219007_Chip-Seq_Bcells_Human1.00340154
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00298151
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99882334
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99710104
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99210624
82NCOR_22424771_ChIP-Seq_293T_Human0.97890097
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97636884
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97198219
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97075835
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96989866
87EWS_26573619_Chip-Seq_HEK293_Human0.95993661
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95274878
89VDR_23849224_ChIP-Seq_CD4+_Human0.95090085
90GABP_19822575_ChIP-Seq_HepG2_Human0.95035137
91IGF1R_20145208_ChIP-Seq_DFB_Human0.94871689
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93648476
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91941538
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.89864990
95CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89807038
96MYC_19829295_ChIP-Seq_ESCs_Human0.89142261
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87481685
98P68_20966046_ChIP-Seq_HELA_Human0.87099425
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.86854681
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86678504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.73944357
2MP0006292_abnormal_olfactory_placode5.30250354
3MP0003787_abnormal_imprinting3.51898632
4MP0002653_abnormal_ependyma_morphology3.41565211
5MP0003122_maternal_imprinting3.20353177
6MP0008789_abnormal_olfactory_epithelium2.88152953
7MP0003123_paternal_imprinting2.75973804
8MP0002163_abnormal_gland_morphology2.70224908
9MP0003121_genomic_imprinting2.57200036
10MP0005394_taste/olfaction_phenotype2.42056226
11MP0005499_abnormal_olfactory_system2.42056226
12MP0010030_abnormal_orbit_morphology2.21061795
13MP0004885_abnormal_endolymph2.19602656
14MP0004142_abnormal_muscle_tone2.15456632
15MP0001485_abnormal_pinna_reflex2.12721204
16MP0001293_anophthalmia2.04416801
17MP0000778_abnormal_nervous_system2.03376760
18MP0003878_abnormal_ear_physiology1.99943738
19MP0005377_hearing/vestibular/ear_phenot1.99943738
20MP0008877_abnormal_DNA_methylation1.90483789
21MP0002102_abnormal_ear_morphology1.90215475
22MP0000049_abnormal_middle_ear1.78492238
23MP0001348_abnormal_lacrimal_gland1.68988627
24MP0004133_heterotaxia1.61156731
25MP0002837_dystrophic_cardiac_calcinosis1.60662753
26MP0008875_abnormal_xenobiotic_pharmacok1.56209051
27MP0005646_abnormal_pituitary_gland1.54054722
28MP0002938_white_spotting1.53895020
29MP0001984_abnormal_olfaction1.45139271
30MP0003890_abnormal_embryonic-extraembry1.43672143
31MP0000631_abnormal_neuroendocrine_gland1.43258721
32MP0005551_abnormal_eye_electrophysiolog1.42212534
33MP0003136_yellow_coat_color1.40261124
34MP0001529_abnormal_vocalization1.37923208
35MP0002234_abnormal_pharynx_morphology1.36528206
36MP0000026_abnormal_inner_ear1.35583774
37MP0004742_abnormal_vestibular_system1.33733134
38MP0008872_abnormal_physiological_respon1.32560043
39MP0001968_abnormal_touch/_nociception1.31772319
40MP0003646_muscle_fatigue1.31692019
41MP0005379_endocrine/exocrine_gland_phen1.31083047
42MP0004145_abnormal_muscle_electrophysio1.30092339
43MP0005195_abnormal_posterior_eye1.25795741
44MP0002557_abnormal_social/conspecific_i1.25392311
45MP0002272_abnormal_nervous_system1.24446272
46MP0000569_abnormal_digit_pigmentation1.22881501
47MP0006276_abnormal_autonomic_nervous1.18515672
48MP0002095_abnormal_skin_pigmentation1.17659631
49MP0005408_hypopigmentation1.17056387
50MP0002736_abnormal_nociception_after1.15689020
51MP0005174_abnormal_tail_pigmentation1.14186979
52MP0001440_abnormal_grooming_behavior1.13530226
53MP0005645_abnormal_hypothalamus_physiol1.10853180
54MP0000955_abnormal_spinal_cord1.08173399
55MP0002752_abnormal_somatic_nervous1.05422601
56MP0006072_abnormal_retinal_apoptosis1.05036135
57MP0001963_abnormal_hearing_physiology1.04218488
58MP0003879_abnormal_hair_cell1.03719812
59MP0008775_abnormal_heart_ventricle1.01796803
60MP0001286_abnormal_eye_development1.01482595
61MP0000372_irregular_coat_pigmentation1.01158883
62MP0001986_abnormal_taste_sensitivity0.99502733
63MP0002184_abnormal_innervation0.99418503
64MP0002572_abnormal_emotion/affect_behav0.92977506
65MP0005248_abnormal_Harderian_gland0.92776891
66MP0002638_abnormal_pupillary_reflex0.91454071
67MP0002063_abnormal_learning/memory/cond0.90975949
68MP0001502_abnormal_circadian_rhythm0.90607079
69MP0009745_abnormal_behavioral_response0.89666539
70MP0005423_abnormal_somatic_nervous0.89557154
71MP0002067_abnormal_sensory_capabilities0.87507482
72MP0002876_abnormal_thyroid_physiology0.87062888
73MP0000427_abnormal_hair_cycle0.86137531
74MP0001970_abnormal_pain_threshold0.86111894
75MP0003011_delayed_dark_adaptation0.85626680
76MP0002233_abnormal_nose_morphology0.84112487
77MP0002210_abnormal_sex_determination0.83939888
78MP0003938_abnormal_ear_development0.83095491
79MP0003635_abnormal_synaptic_transmissio0.82516397
80MP0002882_abnormal_neuron_morphology0.81403266
81MP0003186_abnormal_redox_activity0.81170861
82MP0005075_abnormal_melanosome_morpholog0.80469784
83MP0004858_abnormal_nervous_system0.79418278
84MP0002160_abnormal_reproductive_system0.79151582
85MP0001663_abnormal_digestive_system0.78347932
86MP0002152_abnormal_brain_morphology0.78140440
87MP0003937_abnormal_limbs/digits/tail_de0.76676855
88MP0002733_abnormal_thermal_nociception0.75174085
89MP0001486_abnormal_startle_reflex0.73883552
90MP0003861_abnormal_nervous_system0.73712141
91MP0002116_abnormal_craniofacial_bone0.73357444
92MP0005389_reproductive_system_phenotype0.73040197
93MP0003942_abnormal_urinary_system0.72490803
94MP0002734_abnormal_mechanical_nocicepti0.72426797
95MP0002249_abnormal_larynx_morphology0.71233228
96MP0003880_abnormal_central_pattern0.70593175
97MP0001905_abnormal_dopamine_level0.70308777
98MP0001919_abnormal_reproductive_system0.70057229
99MP0002277_abnormal_respiratory_mucosa0.67206347
100MP0005391_vision/eye_phenotype0.67036595

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.40614258
2Pancreatic fibrosis (HP:0100732)4.28764357
3Abnormality of cells of the erythroid lineage (HP:0012130)4.23908743
4Septo-optic dysplasia (HP:0100842)3.94003343
5Molar tooth sign on MRI (HP:0002419)3.92494652
6Abnormality of midbrain morphology (HP:0002418)3.92494652
7Pancreatic cysts (HP:0001737)3.73595338
8True hermaphroditism (HP:0010459)3.56584256
9Type II lissencephaly (HP:0007260)3.48702580
10Macrocytic anemia (HP:0001972)3.28225800
11Acute necrotizing encephalopathy (HP:0006965)3.23567098
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.22096422
13Asplenia (HP:0001746)3.21120865
14Nephronophthisis (HP:0000090)3.18208922
15Absent/shortened dynein arms (HP:0200106)3.12146738
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.12146738
17Abnormal number of erythroid precursors (HP:0012131)3.06574690
18Chronic hepatic failure (HP:0100626)3.04620775
19Medial flaring of the eyebrow (HP:0010747)2.97961418
20Abnormal mitochondria in muscle tissue (HP:0008316)2.87811028
21Pendular nystagmus (HP:0012043)2.87595539
22Cystic liver disease (HP:0006706)2.85410136
23Acute encephalopathy (HP:0006846)2.82996097
24Abnormality of the renal medulla (HP:0100957)2.79358206
25Absent thumb (HP:0009777)2.73138731
26Increased hepatocellular lipid droplets (HP:0006565)2.71250816
27Colon cancer (HP:0003003)2.70040919
28Gait imbalance (HP:0002141)2.69826290
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68951129
30Lipid accumulation in hepatocytes (HP:0006561)2.68100424
31Mitochondrial inheritance (HP:0001427)2.63826453
32Maternal diabetes (HP:0009800)2.62977961
33Growth hormone deficiency (HP:0000824)2.62913966
34Sclerocornea (HP:0000647)2.61540676
35Congenital primary aphakia (HP:0007707)2.57777142
36Abnormal respiratory epithelium morphology (HP:0012253)2.57122053
37Abnormal respiratory motile cilium morphology (HP:0005938)2.57122053
38Anencephaly (HP:0002323)2.55213307
39Progressive macrocephaly (HP:0004481)2.53367627
40Pallor (HP:0000980)2.53008446
41Supernumerary spleens (HP:0009799)2.51454551
42Cerebellar dysplasia (HP:0007033)2.46531187
43Oligodactyly (hands) (HP:0001180)2.46195127
44Postaxial foot polydactyly (HP:0001830)2.42052447
45Nephrogenic diabetes insipidus (HP:0009806)2.39057398
46Increased CSF lactate (HP:0002490)2.36158956
47Abnormal hair whorl (HP:0010721)2.34329102
48Abnormal rod and cone electroretinograms (HP:0008323)2.34080463
49Oligodactyly (HP:0012165)2.30640459
50Adrenal hypoplasia (HP:0000835)2.29963242
51Congenital hepatic fibrosis (HP:0002612)2.27782730
52Abnormality of the labia minora (HP:0012880)2.25875156
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22896072
54Poor coordination (HP:0002370)2.21610177
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.20242905
56Enlarged kidneys (HP:0000105)2.19875239
57Abnormality of the renal cortex (HP:0011035)2.19874634
58Anophthalmia (HP:0000528)2.19236773
59Tubular atrophy (HP:0000092)2.18897131
60Abnormal ciliary motility (HP:0012262)2.17846149
61Rib fusion (HP:0000902)2.14839916
62Depressed nasal ridge (HP:0000457)2.14775856
63Neoplasm of the adrenal cortex (HP:0100641)2.11594129
64Renal Fanconi syndrome (HP:0001994)2.11222819
65Hypoplasia of the radius (HP:0002984)2.10734253
66Congenital stationary night blindness (HP:0007642)2.09713458
67Absent septum pellucidum (HP:0001331)2.09209021
68Abnormality of DNA repair (HP:0003254)2.08047937
69Holoprosencephaly (HP:0001360)2.07362274
70Optic nerve coloboma (HP:0000588)2.06731354
71Optic nerve hypoplasia (HP:0000609)2.06587367
72Hyperglycinemia (HP:0002154)2.02729934
73Hypoplasia of the ulna (HP:0003022)2.02028431
74Diastasis recti (HP:0001540)2.00041960
75Polydipsia (HP:0001959)1.98044422
76Abnormal drinking behavior (HP:0030082)1.98044422
77Myokymia (HP:0002411)1.97896400
78Porencephaly (HP:0002132)1.97187235
79Ectopic kidney (HP:0000086)1.96386060
80Postaxial hand polydactyly (HP:0001162)1.95582540
81Hepatoblastoma (HP:0002884)1.95026941
82Optic disc pallor (HP:0000543)1.94219405
83Forearm undergrowth (HP:0009821)1.91066904
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90240389
85Retinal dysplasia (HP:0007973)1.90070565
86Vaginal atresia (HP:0000148)1.89389936
87Male pseudohermaphroditism (HP:0000037)1.89379708
88Stenosis of the external auditory canal (HP:0000402)1.88685049
89Abnormal respiratory motile cilium physiology (HP:0012261)1.88257510
90Dandy-Walker malformation (HP:0001305)1.86541563
91Decreased central vision (HP:0007663)1.83697428
92Cerebral edema (HP:0002181)1.82273065
93Lissencephaly (HP:0001339)1.80305485
94Abnormal number of incisors (HP:0011064)1.80080726
95Abnormality of the aortic arch (HP:0012303)1.78782699
96Genital tract atresia (HP:0001827)1.77669901
97Abolished electroretinogram (ERG) (HP:0000550)1.77513912
98Aplasia/Hypoplasia of the ulna (HP:0006495)1.75937857
99Preaxial hand polydactyly (HP:0001177)1.75003854
100Increased intramyocellular lipid droplets (HP:0012240)1.74031544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.24920948
2DYRK23.24053128
3CDK192.99673332
4BCKDK2.44930923
5CDC72.40834590
6WNK42.39490436
7ADRBK22.25707216
8TXK2.25514174
9TNIK2.21668074
10LRRK22.10304591
11NUAK12.05983353
12CAMKK21.99635141
13PRKD31.99508909
14TIE11.88507173
15MAP3K111.81721565
16ZAK1.80007483
17TYRO31.69469501
18GRK11.65287515
19EPHB21.59352785
20FRK1.57235803
21CAMK11.55620415
22CAMKK11.54360350
23WNK11.50960607
24MAP4K21.44639031
25PIK3CA1.42975812
26PINK11.42939167
27STK111.39409214
28DYRK1B1.35826681
29PRKCG1.20088051
30PRKCH1.17840320
31NTRK21.17404721
32MAP3K121.16558215
33WNK31.15277111
34VRK21.12063104
35EPHA31.10470934
36BMPR1B1.10218853
37MAPK151.08544039
38PBK1.08241054
39CAMK1D1.07690230
40EPHA41.07547632
41NME11.07234562
42TLK11.07144854
43PASK1.06805210
44LIMK11.06723487
45PAK31.04803015
46DAPK30.97054618
47CASK0.93725507
48ADRBK10.93264793
49CAMK40.90123987
50TAF10.89409606
51CSNK1G20.81319804
52PLK40.79746136
53AURKB0.79700398
54SIK20.78944169
55MAPK130.76402432
56MAP4K10.73989186
57DYRK30.73147353
58BTK0.70584518
59RPS6KA60.70228520
60HIPK20.68100037
61NTRK30.68050932
62CAMK1G0.67212769
63PRKCZ0.66771398
64STK390.66732062
65DMPK0.66621970
66VRK10.66256027
67PRKACA0.65706100
68SGK2230.63786579
69SGK4940.63786579
70MAP2K70.62540477
71PRKCQ0.62439114
72MARK30.62317884
73CSNK1G30.61204648
74INSRR0.60762462
75OXSR10.59869269
76PKN10.59619592
77MARK20.59232033
78PRKD20.59168459
79PRKCI0.59037623
80MKNK20.59012191
81ITK0.58898904
82CSNK2A20.57583187
83PHKG20.56001631
84PHKG10.56001631
85NEK20.55860359
86ATR0.53822839
87DAPK20.53310027
88BRAF0.51330206
89CSNK1A1L0.48605394
90MAP3K40.46688169
91RPS6KC10.46071248
92RPS6KL10.46071248
93CDK50.45262740
94AURKA0.44032192
95PRKAA20.43600458
96PRKCE0.43199118
97ABL20.42904611
98PRKCD0.41996117
99GRK50.41010511
100PRKCA0.40689793

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.28171872
2Oxidative phosphorylation_Homo sapiens_hsa001903.43564075
3Parkinsons disease_Homo sapiens_hsa050122.67595711
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.57541734
5Sulfur relay system_Homo sapiens_hsa041222.46292626
6Cardiac muscle contraction_Homo sapiens_hsa042602.41589506
7RNA polymerase_Homo sapiens_hsa030202.27776013
8Huntingtons disease_Homo sapiens_hsa050162.14482558
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01763603
10Linoleic acid metabolism_Homo sapiens_hsa005911.82502498
11Alzheimers disease_Homo sapiens_hsa050101.76421056
12Protein export_Homo sapiens_hsa030601.75404621
13Mismatch repair_Homo sapiens_hsa034301.73102732
14Homologous recombination_Homo sapiens_hsa034401.71979053
15Fanconi anemia pathway_Homo sapiens_hsa034601.69630526
16Phototransduction_Homo sapiens_hsa047441.69383977
17RNA degradation_Homo sapiens_hsa030181.67404237
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63652194
19Basal cell carcinoma_Homo sapiens_hsa052171.60845515
20Basal transcription factors_Homo sapiens_hsa030221.58306647
21One carbon pool by folate_Homo sapiens_hsa006701.53962980
22Caffeine metabolism_Homo sapiens_hsa002321.48050333
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46077088
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45951595
25Hedgehog signaling pathway_Homo sapiens_hsa043401.39563286
26Nicotine addiction_Homo sapiens_hsa050331.36591577
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29198310
28Pyrimidine metabolism_Homo sapiens_hsa002401.28986693
29Notch signaling pathway_Homo sapiens_hsa043301.23508333
30Nucleotide excision repair_Homo sapiens_hsa034201.23362751
31DNA replication_Homo sapiens_hsa030301.22793629
32Asthma_Homo sapiens_hsa053101.19561077
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11716137
34Steroid biosynthesis_Homo sapiens_hsa001001.11310896
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11224472
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06710232
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06657726
38Proteasome_Homo sapiens_hsa030501.05698277
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.02181970
40Primary immunodeficiency_Homo sapiens_hsa053400.92692558
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90976442
42Peroxisome_Homo sapiens_hsa041460.88723353
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85321713
44Folate biosynthesis_Homo sapiens_hsa007900.85180018
45Base excision repair_Homo sapiens_hsa034100.85033666
46Arachidonic acid metabolism_Homo sapiens_hsa005900.84468281
47Morphine addiction_Homo sapiens_hsa050320.84411520
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.83744428
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83728261
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.82839283
51Purine metabolism_Homo sapiens_hsa002300.78241878
52Butanoate metabolism_Homo sapiens_hsa006500.77794721
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75659086
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74416324
55Fat digestion and absorption_Homo sapiens_hsa049750.73236322
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73006438
57Ether lipid metabolism_Homo sapiens_hsa005650.70785602
58Chemical carcinogenesis_Homo sapiens_hsa052040.69501809
59Regulation of autophagy_Homo sapiens_hsa041400.67958573
60Collecting duct acid secretion_Homo sapiens_hsa049660.66934744
61Propanoate metabolism_Homo sapiens_hsa006400.66732121
62Olfactory transduction_Homo sapiens_hsa047400.66281156
63Metabolic pathways_Homo sapiens_hsa011000.64757680
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64396630
65Hippo signaling pathway_Homo sapiens_hsa043900.63773375
66Retinol metabolism_Homo sapiens_hsa008300.63741167
67Insulin secretion_Homo sapiens_hsa049110.60924830
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59042819
69Arginine and proline metabolism_Homo sapiens_hsa003300.57984015
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55253453
71Nitrogen metabolism_Homo sapiens_hsa009100.53881585
72Ovarian steroidogenesis_Homo sapiens_hsa049130.53270764
73Tryptophan metabolism_Homo sapiens_hsa003800.52887157
74RNA transport_Homo sapiens_hsa030130.51614319
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51477181
76Fatty acid degradation_Homo sapiens_hsa000710.49393646
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48503736
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44987074
79Axon guidance_Homo sapiens_hsa043600.44267506
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43800778
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43155482
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.42818655
83Glutamatergic synapse_Homo sapiens_hsa047240.42349675
84GABAergic synapse_Homo sapiens_hsa047270.42029372
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41982731
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40334320
87Allograft rejection_Homo sapiens_hsa053300.38781621
88Wnt signaling pathway_Homo sapiens_hsa043100.36730925
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.35208503
90Spliceosome_Homo sapiens_hsa030400.34517153
91Glutathione metabolism_Homo sapiens_hsa004800.34165615
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32969929
93Autoimmune thyroid disease_Homo sapiens_hsa053200.32288534
94Starch and sucrose metabolism_Homo sapiens_hsa005000.32283662
95Glycerolipid metabolism_Homo sapiens_hsa005610.32078690
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.29652025
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28810379
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28777218
99Selenocompound metabolism_Homo sapiens_hsa004500.27196320
100Fatty acid biosynthesis_Homo sapiens_hsa000610.27017161

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