ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.51415105
2	viral transcription (GO:0019083)	6.83857459
3	translational termination (GO:0006415)	6.52759499
4	ribosomal small subunit biogenesis (GO:0042274)	6.14037326
5	maturation of SSU-rRNA (GO:0030490)	5.87394080
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.64993391
7	cotranslational protein targeting to membrane (GO:0006613)	5.58770766
8	translational elongation (GO:0006414)	5.56976281
9	protein targeting to ER (GO:0045047)	5.56879107
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.39151863
11	ATP synthesis coupled proton transport (GO:0015986)	5.39151863
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.35104738
13	protein localization to endoplasmic reticulum (GO:0070972)	5.25790701
14	viral life cycle (GO:0019058)	5.05256788
15	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.04432822
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.94311282
17	cellular protein complex disassembly (GO:0043624)	4.82237191
18	translational initiation (GO:0006413)	4.69886618
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.68722500
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.45790790
21	DNA deamination (GO:0045006)	4.16220357
22	regulation of isotype switching to IgG isotypes (GO:0048302)	4.13561180
23	tryptophan catabolic process (GO:0006569)	4.06019810
24	indole-containing compound catabolic process (GO:0042436)	4.06019810
25	indolalkylamine catabolic process (GO:0046218)	4.06019810
26	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.05532113
27	positive regulation of interleukin-17 production (GO:0032740)	4.03252295
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.02984638
29	translation (GO:0006412)	3.98597344
30	protein complex disassembly (GO:0043241)	3.98506610
31	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.95095536
32	substrate-independent telencephalic tangential migration (GO:0021826)	3.95095536
33	protein complex biogenesis (GO:0070271)	3.92793638
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.76105286
35	macromolecular complex disassembly (GO:0032984)	3.74044263
36	protein targeting to membrane (GO:0006612)	3.73952249
37	ribosomal large subunit biogenesis (GO:0042273)	3.64314712
38	electron transport chain (GO:0022900)	3.63625427
39	respiratory electron transport chain (GO:0022904)	3.62883846
40	response to xenobiotic stimulus (GO:0009410)	3.58339599
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53266857
42	NADH dehydrogenase complex assembly (GO:0010257)	3.53266857
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53266857
44	GTP biosynthetic process (GO:0006183)	3.51603805
45	protein neddylation (GO:0045116)	3.49574468
46	chaperone-mediated protein transport (GO:0072321)	3.46033737
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.41090864
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38119607
49	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.37120571
50	regulation of regulatory T cell differentiation (GO:0045589)	3.33592188
51	negative regulation of B cell apoptotic process (GO:0002903)	3.31625057
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30671712
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.29772420
54	kynurenine metabolic process (GO:0070189)	3.27448574
55	cellular component biogenesis (GO:0044085)	3.27348627
56	behavioral response to nicotine (GO:0035095)	3.24838152
57	ATP biosynthetic process (GO:0006754)	3.22878298
58	amine catabolic process (GO:0009310)	3.22608058
59	cellular biogenic amine catabolic process (GO:0042402)	3.22608058
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.22005349
61	platelet dense granule organization (GO:0060155)	3.21655473
62	mRNA catabolic process (GO:0006402)	3.20573147
63	ribonucleoprotein complex biogenesis (GO:0022613)	3.18621075
64	respiratory chain complex IV assembly (GO:0008535)	3.17473907
65	rRNA processing (GO:0006364)	3.10982771
66	hydrogen ion transmembrane transport (GO:1902600)	3.09275779
67	rRNA metabolic process (GO:0016072)	3.06717849
68	UTP biosynthetic process (GO:0006228)	3.03764271
69	tryptophan metabolic process (GO:0006568)	2.99342965
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98696480
71	RNA catabolic process (GO:0006401)	2.97589544
72	regulation of mitochondrial translation (GO:0070129)	2.96700961
73	tongue development (GO:0043586)	2.96599421
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95417851
75	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.91779923
76	indolalkylamine metabolic process (GO:0006586)	2.87696748
77	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.86465639
78	cytochrome complex assembly (GO:0017004)	2.82996906
79	UTP metabolic process (GO:0046051)	2.78115236
80	positive regulation of isotype switching (GO:0045830)	2.76872207
81	dopamine transport (GO:0015872)	2.75347199
82	proton transport (GO:0015992)	2.74132741
83	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73987201
84	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73987201
85	regulation of immunoglobulin secretion (GO:0051023)	2.73489045
86	regulation of acrosome reaction (GO:0060046)	2.71449969
87	negative regulation of telomere maintenance (GO:0032205)	2.69884093
88	hydrogen transport (GO:0006818)	2.66109210
89	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.65271385
90	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.64837039
91	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.62917198
92	response to pheromone (GO:0019236)	2.58395508
93	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.58104622
94	multicellular organism reproduction (GO:0032504)	2.57879548
95	positive regulation of DNA recombination (GO:0045911)	2.56107551
96	CTP biosynthetic process (GO:0006241)	2.55330029
97	CTP metabolic process (GO:0046036)	2.55330029
98	peptidyl-histidine modification (GO:0018202)	2.55299216
99	nucleoside triphosphate biosynthetic process (GO:0009142)	2.54428320
100	establishment of protein localization to membrane (GO:0090150)	2.53654883

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.96971493
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.95096475
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.85902120
4	VDR_22108803_ChIP-Seq_LS180_Human	3.52742397
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.12018326
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08294484
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.03527459
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97917709
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86121815
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.76202542
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.60726010
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.59659048
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53730512
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.52533153
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.18079831
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.16619403
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.07982956
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.01560604
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95969570
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.88691299
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85192875
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.82302009
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82091389
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79870996
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75480243
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71705349
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.71486933
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.57921779
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51680992
30	EWS_26573619_Chip-Seq_HEK293_Human	1.51268437
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48549147
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44484150
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.43865903
34	FUS_26573619_Chip-Seq_HEK293_Human	1.42410492
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.40151096
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36642869
37	P53_21459846_ChIP-Seq_SAOS-2_Human	1.35080964
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32790316
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31754489
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.30390273
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.27856821
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27113252
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26070375
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25040206
45	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.25015825
46	NCOR_22424771_ChIP-Seq_293T_Human	1.24824062
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23689880
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23599977
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23202752
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22807506
51	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.22110172
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19994313
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.17643604
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15901380
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.15351350
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12593483
57	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12064987
58	AR_20517297_ChIP-Seq_VCAP_Human	1.10062987
59	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.08287688
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07613104
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06987782
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06525190
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04996102
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.04566873
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.04445473
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04342167
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04342167
68	PHF8_20622853_ChIP-Seq_HELA_Human	1.03739123
69	P300_19829295_ChIP-Seq_ESCs_Human	1.02698681
70	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.02322758
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01910581
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01910581
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00446551
74	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98916485
75	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.98890470
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98159589
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97527212
78	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97360334
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.96725389
80	ERA_21632823_ChIP-Seq_H3396_Human	0.96124815
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95578160
82	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94470689
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94131564
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93524972
85	REST_21632747_ChIP-Seq_MESCs_Mouse	0.93496518
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92644578
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92644578
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.89777473
89	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89740618
90	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89483541
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.88391991
92	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.86967164
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.86837942
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86806323
95	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.86464063
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.85583487
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85272933
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.85135970
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.84303398
100	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.84298627

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.93662677
2	MP0006292_abnormal_olfactory_placode	4.76009509
3	MP0005360_urolithiasis	4.25057582
4	MP0002102_abnormal_ear_morphology	3.96410267
5	MP0002638_abnormal_pupillary_reflex	3.21858886
6	MP0005377_hearing/vestibular/ear_phenot	2.91174090
7	MP0003878_abnormal_ear_physiology	2.91174090
8	MP0004147_increased_porphyrin_level	2.73008753
9	MP0002138_abnormal_hepatobiliary_system	2.60664717
10	MP0001835_abnormal_antigen_presentation	2.46780339
11	MP0005379_endocrine/exocrine_gland_phen	2.22265282
12	MP0002653_abnormal_ependyma_morphology	2.18481303
13	MP0002163_abnormal_gland_morphology	1.95111202
14	MP0008789_abnormal_olfactory_epithelium	1.80623568
15	MP0004043_abnormal_pH_regulation	1.77702661
16	MP0008877_abnormal_DNA_methylation	1.68671592
17	MP0000049_abnormal_middle_ear	1.68368172
18	MP0002234_abnormal_pharynx_morphology	1.67462235
19	MP0002837_dystrophic_cardiac_calcinosis	1.58279806
20	MP0005551_abnormal_eye_electrophysiolog	1.56737523
21	MP0002736_abnormal_nociception_after	1.54972124
22	MP0009333_abnormal_splenocyte_physiolog	1.54852669
23	MP0004142_abnormal_muscle_tone	1.53985553
24	MP0001968_abnormal_touch/_nociception	1.45620038
25	MP0006072_abnormal_retinal_apoptosis	1.45329242
26	MP0001873_stomach_inflammation	1.41232898
27	MP0008875_abnormal_xenobiotic_pharmacok	1.39476262
28	MP0001986_abnormal_taste_sensitivity	1.38790687
29	MP0001853_heart_inflammation	1.36701636
30	MP0005253_abnormal_eye_physiology	1.33815707
31	MP0008872_abnormal_physiological_respon	1.33647956
32	MP0003938_abnormal_ear_development	1.32169122
33	MP0001293_anophthalmia	1.30058887
34	MP0000372_irregular_coat_pigmentation	1.29515199
35	MP0003186_abnormal_redox_activity	1.23120614
36	MP0004019_abnormal_vitamin_homeostasis	1.22479379
37	MP0004885_abnormal_endolymph	1.22094757
38	MP0005394_taste/olfaction_phenotype	1.21476154
39	MP0005499_abnormal_olfactory_system	1.21476154
40	MP0008004_abnormal_stomach_pH	1.19727023
41	MP0005671_abnormal_response_to	1.15367571
42	MP0003283_abnormal_digestive_organ	1.15102789
43	MP0002272_abnormal_nervous_system	1.14377990
44	MP0001905_abnormal_dopamine_level	1.14361307
45	MP0000427_abnormal_hair_cycle	1.14062355
46	MP0002095_abnormal_skin_pigmentation	1.09919232
47	MP0001270_distended_abdomen	1.05773688
48	MP0000631_abnormal_neuroendocrine_gland	1.05191948
49	MP0001502_abnormal_circadian_rhythm	0.98913655
50	MP0000538_abnormal_urinary_bladder	0.98846799
51	MP0001485_abnormal_pinna_reflex	0.97806760
52	MP0000026_abnormal_inner_ear	0.93639900
53	MP0001348_abnormal_lacrimal_gland	0.92250212
54	MP0002733_abnormal_thermal_nociception	0.92217279
55	MP0006276_abnormal_autonomic_nervous	0.91781423
56	MP0003646_muscle_fatigue	0.91706576
57	MP0005646_abnormal_pituitary_gland	0.91105295
58	MP0001486_abnormal_startle_reflex	0.90802106
59	MP0002233_abnormal_nose_morphology	0.90732537
60	MP0002938_white_spotting	0.90612429
61	MP0002148_abnormal_hypersensitivity_rea	0.89369103
62	MP0009745_abnormal_behavioral_response	0.88727186
63	MP0004782_abnormal_surfactant_physiolog	0.87850454
64	MP0005084_abnormal_gallbladder_morpholo	0.87258282
65	MP0000613_abnormal_salivary_gland	0.86293084
66	MP0001970_abnormal_pain_threshold	0.84420743
67	MP0005195_abnormal_posterior_eye	0.83427614
68	MP0001765_abnormal_ion_homeostasis	0.82596918
69	MP0009053_abnormal_anal_canal	0.81922179
70	MP0002752_abnormal_somatic_nervous	0.81071765
71	MP0000470_abnormal_stomach_morphology	0.79686082
72	MP0002184_abnormal_innervation	0.79103255
73	MP0005410_abnormal_fertilization	0.78048091
74	MP0003787_abnormal_imprinting	0.77759743
75	MP0001800_abnormal_humoral_immune	0.76447756
76	MP0005391_vision/eye_phenotype	0.75865261
77	MP0002876_abnormal_thyroid_physiology	0.74611267
78	MP0003122_maternal_imprinting	0.74093461
79	MP0000569_abnormal_digit_pigmentation	0.73457484
80	MP0003567_abnormal_fetal_cardiomyocyte	0.73451580
81	MP0005423_abnormal_somatic_nervous	0.72686451
82	MP0001756_abnormal_urination	0.71197031
83	MP0001663_abnormal_digestive_system	0.70955196
84	MP0000383_abnormal_hair_follicle	0.70723403
85	MP0005381_digestive/alimentary_phenotyp	0.70292188
86	MP0001958_emphysema	0.70272215
87	MP0000678_abnormal_parathyroid_gland	0.70248343
88	MP0003879_abnormal_hair_cell	0.70097497
89	MP0002572_abnormal_emotion/affect_behav	0.68498027
90	MP0000230_abnormal_systemic_arterial	0.68296305
91	MP0002210_abnormal_sex_determination	0.67815133
92	MP0003119_abnormal_digestive_system	0.67340309
93	MP0004145_abnormal_muscle_electrophysio	0.66173471
94	MP0009764_decreased_sensitivity_to	0.64957906
95	MP0003806_abnormal_nucleotide_metabolis	0.64845054
96	MP0005332_abnormal_amino_acid	0.63451609
97	MP0002277_abnormal_respiratory_mucosa	0.62283683
98	MP0002282_abnormal_trachea_morphology	0.61992465
99	MP0002909_abnormal_adrenal_gland	0.60644472
100	MP0001119_abnormal_female_reproductive	0.60050819

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.70014696
2	Reticulocytopenia (HP:0001896)	4.35612369
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.10790831
4	Acute encephalopathy (HP:0006846)	4.03582263
5	Increased CSF lactate (HP:0002490)	3.94801949
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.89015402
7	Progressive macrocephaly (HP:0004481)	3.85740879
8	Mitochondrial inheritance (HP:0001427)	3.81980383
9	Pancreatic fibrosis (HP:0100732)	3.71662837
10	Pancreatic cysts (HP:0001737)	3.52613021
11	Molar tooth sign on MRI (HP:0002419)	3.45080555
12	Abnormality of midbrain morphology (HP:0002418)	3.45080555
13	Macrocytic anemia (HP:0001972)	3.32169851
14	Nephronophthisis (HP:0000090)	3.30935373
15	Abnormal number of erythroid precursors (HP:0012131)	3.28326007
16	Congenital, generalized hypertrichosis (HP:0004540)	3.25240350
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15451725
18	Type II lissencephaly (HP:0007260)	3.11122099
19	Increased hepatocellular lipid droplets (HP:0006565)	3.10304045
20	True hermaphroditism (HP:0010459)	2.96881857
21	Cerebral edema (HP:0002181)	2.96451433
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.95779016
23	Septo-optic dysplasia (HP:0100842)	2.90933703
24	Hepatic necrosis (HP:0002605)	2.86616908
25	Severe muscular hypotonia (HP:0006829)	2.86279183
26	Lipid accumulation in hepatocytes (HP:0006561)	2.82809974
27	Disproportionate short-trunk short stature (HP:0003521)	2.80772593
28	Congenital stationary night blindness (HP:0007642)	2.79559485
29	Hepatocellular necrosis (HP:0001404)	2.77825993
30	Abnormality of the pons (HP:0007361)	2.75084512
31	Hypoplasia of the pons (HP:0012110)	2.70823205
32	Abnormality of the renal medulla (HP:0100957)	2.70140347
33	Pendular nystagmus (HP:0012043)	2.69453441
34	Cerebellar dysplasia (HP:0007033)	2.66119920
35	Optic disc pallor (HP:0000543)	2.55734739
36	Cystic liver disease (HP:0006706)	2.55678758
37	Abnormality of the renal cortex (HP:0011035)	2.45010160
38	Renal cortical cysts (HP:0000803)	2.43738671
39	Anencephaly (HP:0002323)	2.40536026
40	Renal Fanconi syndrome (HP:0001994)	2.37667643
41	Generalized aminoaciduria (HP:0002909)	2.33613269
42	Hyperglycinemia (HP:0002154)	2.26126783
43	Rib fusion (HP:0000902)	2.24863432
44	Porencephaly (HP:0002132)	2.24295016
45	Pallor (HP:0000980)	2.22614626
46	Congenital hepatic fibrosis (HP:0002612)	2.19164990
47	Leukodystrophy (HP:0002415)	2.19027288
48	Aplastic anemia (HP:0001915)	2.14744620
49	Attenuation of retinal blood vessels (HP:0007843)	2.13088832
50	Absent thumb (HP:0009777)	2.13023179
51	Decreased circulating renin level (HP:0003351)	2.12266064
52	Increased serum lactate (HP:0002151)	2.10327413
53	Abnormality of renal resorption (HP:0011038)	2.09594935
54	Lethargy (HP:0001254)	2.07419788
55	Pancytopenia (HP:0001876)	2.07013167
56	Optic nerve coloboma (HP:0000588)	2.06839715
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.06077874
58	Absent/shortened dynein arms (HP:0200106)	2.06077874
59	Lactic acidosis (HP:0003128)	2.04136649
60	Cleft eyelid (HP:0000625)	2.03134087
61	Exertional dyspnea (HP:0002875)	2.01989290
62	Abnormal drinking behavior (HP:0030082)	2.00718222
63	Polydipsia (HP:0001959)	2.00718222
64	Mixed hearing impairment (HP:0000410)	2.00471772
65	Renal dysplasia (HP:0000110)	2.00297146
66	Hypoplasia of the ulna (HP:0003022)	1.99778450
67	Myokymia (HP:0002411)	1.97834197
68	Elevated erythrocyte sedimentation rate (HP:0003565)	1.97425670
69	Tubular atrophy (HP:0000092)	1.96031980
70	Glycosuria (HP:0003076)	1.95732819
71	Abnormality of urine glucose concentration (HP:0011016)	1.95732819
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.95455206
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.95455206
74	Testicular atrophy (HP:0000029)	1.95236177
75	Optic nerve hypoplasia (HP:0000609)	1.93953597
76	Hypoplasia of the radius (HP:0002984)	1.93540880
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92973997
78	Abolished electroretinogram (ERG) (HP:0000550)	1.92857317
79	Chronic hepatic failure (HP:0100626)	1.91046066
80	Abnormality of magnesium homeostasis (HP:0004921)	1.90921111
81	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88300842
82	Sclerocornea (HP:0000647)	1.88292953
83	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87409302
84	Stenosis of the external auditory canal (HP:0000402)	1.85246294
85	Nausea (HP:0002018)	1.85104389
86	Hypomagnesemia (HP:0002917)	1.83127508
87	Respiratory failure (HP:0002878)	1.82503348
88	Asplenia (HP:0001746)	1.80553643
89	Poor suck (HP:0002033)	1.79980269
90	Abnormal ciliary motility (HP:0012262)	1.78156213
91	Type 2 muscle fiber atrophy (HP:0003554)	1.78154249
92	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.77791632
93	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.77748628
94	Arthropathy (HP:0003040)	1.76808524
95	Forearm undergrowth (HP:0009821)	1.76472417
96	Stomatitis (HP:0010280)	1.75904823
97	Short hallux (HP:0010109)	1.74737063
98	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.74266023
99	Proximal tubulopathy (HP:0000114)	1.74175130
100	Depressed nasal ridge (HP:0000457)	1.69459597

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.65419313
2	WNK4	3.63166143
3	NEK1	3.17733356
4	CDK8	3.12676812
5	BMPR1B	3.00758636
6	TXK	2.98674157
7	ADRBK2	2.47191757
8	TLK1	2.23915209
9	GRK1	2.14027516
10	STK39	2.05787145
11	TGFBR1	1.87853333
12	WNK1	1.87283399
13	NUAK1	1.85911962
14	FRK	1.47379589
15	ZAK	1.45717957
16	PLK4	1.43093073
17	CAMKK2	1.34898812
18	NME2	1.34472333
19	MARK3	1.33058100
20	NME1	1.32014698
21	DYRK2	1.29959765
22	PIK3CG	1.29821863
23	TAOK3	1.29575698
24	PIK3CA	1.29533805
25	CDK19	1.29304411
26	OXSR1	1.23409700
27	CAMK1D	1.19510809
28	SIK2	1.19371239
29	TSSK6	1.16997913
30	ACVR1B	1.15225342
31	NEK2	1.14274139
32	PRKCG	1.04275683
33	BCKDK	1.03383271
34	PASK	1.01842721
35	PHKG2	1.01030826
36	PHKG1	1.01030826
37	MAP4K2	0.99270722
38	SIK3	0.98337400
39	MAP3K12	0.97878713
40	PRKCQ	0.96120364
41	MKNK2	0.94973214
42	PLK2	0.93939933
43	CAMK1	0.93780942
44	ABL2	0.92291788
45	CAMK1G	0.90617494
46	ADRBK1	0.89434177
47	TEC	0.87962860
48	DAPK3	0.87868170
49	PINK1	0.87566619
50	INSRR	0.84492558
51	TIE1	0.83703019
52	TESK1	0.83696476
53	TNK2	0.82238785
54	DMPK	0.82162855
55	RPS6KA5	0.81136827
56	ILK	0.80530332
57	TAF1	0.79599192
58	ITK	0.78693477
59	PRKCE	0.76098122
60	SCYL2	0.76047800
61	WNK3	0.75555065
62	MAP4K1	0.66992635
63	FLT3	0.65585066
64	VRK2	0.65018694
65	PRKACA	0.64372993
66	VRK1	0.64012135
67	RPS6KA6	0.63152559
68	JAK3	0.63150313
69	IKBKB	0.62248928
70	STK11	0.61866858
71	PBK	0.61858752
72	PLK3	0.60253419
73	CSNK2A2	0.56841382
74	LYN	0.55191338
75	IRAK1	0.53553156
76	MAP2K6	0.53545337
77	RIPK4	0.52998532
78	PRKG1	0.52955641
79	PDK2	0.52121850
80	BRD4	0.51761386
81	PRKCA	0.49117425
82	CDK7	0.49042081
83	BRSK2	0.48819579
84	MAPK13	0.48166013
85	BTK	0.46730219
86	RPS6KL1	0.46007455
87	RPS6KC1	0.46007455
88	EPHA4	0.45468488
89	MATK	0.43775218
90	LRRK2	0.43472569
91	PAK3	0.41801999
92	PLK1	0.40728220
93	IGF1R	0.39746326
94	MKNK1	0.39617909
95	STK38L	0.39190273
96	CAMK2D	0.38476031
97	STK3	0.38442818
98	OBSCN	0.37678628
99	KIT	0.36903385
100	PRKACG	0.36683300

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.83418284
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.93733864
3	Parkinsons disease_Homo sapiens_hsa05012	3.48534613
4	Proteasome_Homo sapiens_hsa03050	2.83986149
5	Asthma_Homo sapiens_hsa05310	2.66686687
6	Allograft rejection_Homo sapiens_hsa05330	2.36656548
7	One carbon pool by folate_Homo sapiens_hsa00670	2.30720674
8	Huntingtons disease_Homo sapiens_hsa05016	2.30397083
9	Alzheimers disease_Homo sapiens_hsa05010	2.24476668
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.12823927
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12036702
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.10073654
13	Protein export_Homo sapiens_hsa03060	2.06849010
14	Cardiac muscle contraction_Homo sapiens_hsa04260	2.06094525
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.97518498
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.87315206
17	RNA polymerase_Homo sapiens_hsa03020	1.80956858
18	Basal transcription factors_Homo sapiens_hsa03022	1.74673293
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73470826
20	RNA degradation_Homo sapiens_hsa03018	1.72467345
21	Phototransduction_Homo sapiens_hsa04744	1.70845029
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70318351
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55895013
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.44953268
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.44655752
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39836571
27	Sulfur relay system_Homo sapiens_hsa04122	1.33989766
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.30958112
29	Olfactory transduction_Homo sapiens_hsa04740	1.29966513
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27550475
31	Homologous recombination_Homo sapiens_hsa03440	1.26129951
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.24650841
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.23267268
34	RNA transport_Homo sapiens_hsa03013	1.14758409
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13497227
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02667907
37	Propanoate metabolism_Homo sapiens_hsa00640	1.00794585
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95717283
39	Folate biosynthesis_Homo sapiens_hsa00790	0.92718712
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.89378171
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87962593
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85561388
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85282524
44	Purine metabolism_Homo sapiens_hsa00230	0.78532900
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74692467
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.74275859
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73652499
48	Caffeine metabolism_Homo sapiens_hsa00232	0.69319909
49	Base excision repair_Homo sapiens_hsa03410	0.68086023
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67203175
51	Morphine addiction_Homo sapiens_hsa05032	0.66149538
52	Glutathione metabolism_Homo sapiens_hsa00480	0.65803218
53	Regulation of autophagy_Homo sapiens_hsa04140	0.65223581
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64975107
55	Retinol metabolism_Homo sapiens_hsa00830	0.63644814
56	Serotonergic synapse_Homo sapiens_hsa04726	0.61994028
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61989071
58	Butanoate metabolism_Homo sapiens_hsa00650	0.59949656
59	Taste transduction_Homo sapiens_hsa04742	0.58582543
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58183669
61	Peroxisome_Homo sapiens_hsa04146	0.57419718
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57173645
63	Metabolic pathways_Homo sapiens_hsa01100	0.55431817
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52969886
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.50778475
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50609361
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50116693
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50011350
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47297111
70	Mismatch repair_Homo sapiens_hsa03430	0.47018288
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.45953024
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45633583
73	Antigen processing and presentation_Homo sapiens_hsa04612	0.44294570
74	Mineral absorption_Homo sapiens_hsa04978	0.44065542
75	Sulfur metabolism_Homo sapiens_hsa00920	0.43294704
76	Insulin secretion_Homo sapiens_hsa04911	0.42738166
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.42701121
78	African trypanosomiasis_Homo sapiens_hsa05143	0.42001380
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41908162
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41557922
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41292124
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.41117427
83	Circadian entrainment_Homo sapiens_hsa04713	0.40833555
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38684968
85	Fatty acid degradation_Homo sapiens_hsa00071	0.34073130
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33079424
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27093014
88	DNA replication_Homo sapiens_hsa03030	0.25221889
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.24335685
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22756391
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.22459526
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.21618906
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21494479
94	Salivary secretion_Homo sapiens_hsa04970	0.21380690
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.20878783
96	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.20834556
97	Nicotine addiction_Homo sapiens_hsa05033	0.19481568
98	GABAergic synapse_Homo sapiens_hsa04727	0.19186158
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.16728505
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.16542322

RPS15AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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