ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.18051050
2	presynaptic membrane assembly (GO:0097105)	4.97280432
3	nonmotile primary cilium assembly (GO:0035058)	4.86268199
4	behavioral response to nicotine (GO:0035095)	4.57735275
5	presynaptic membrane organization (GO:0097090)	4.29501174
6	brain morphogenesis (GO:0048854)	4.19801336
7	postsynaptic membrane organization (GO:0001941)	4.10716212
8	axoneme assembly (GO:0035082)	4.09316753
9	ubiquinone metabolic process (GO:0006743)	3.92090529
10	serotonin metabolic process (GO:0042428)	3.84603251
11	replication fork processing (GO:0031297)	3.82597056
12	indolalkylamine metabolic process (GO:0006586)	3.80881364
13	dopamine transport (GO:0015872)	3.75174652
14	protein complex biogenesis (GO:0070271)	3.72765234
15	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.71175855
16	ubiquinone biosynthetic process (GO:0006744)	3.57260933
17	regulation of cilium movement (GO:0003352)	3.54888757
18	mitochondrial respiratory chain complex assembly (GO:0033108)	3.40941709
19	resolution of meiotic recombination intermediates (GO:0000712)	3.39208192
20	dorsal/ventral axis specification (GO:0009950)	3.30940513
21	primary amino compound metabolic process (GO:1901160)	3.30892056
22	platelet dense granule organization (GO:0060155)	3.25331019
23	negative regulation of response to food (GO:0032096)	3.24132553
24	negative regulation of appetite (GO:0032099)	3.24132553
25	cytochrome complex assembly (GO:0017004)	3.23556764
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.22122618
27	ganglion development (GO:0061548)	3.21752617
28	DNA double-strand break processing (GO:0000729)	3.17362211
29	olfactory bulb development (GO:0021772)	3.16269312
30	transmission of nerve impulse (GO:0019226)	3.14823916
31	dentate gyrus development (GO:0021542)	3.13736250
32	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.13576825
33	cilium morphogenesis (GO:0060271)	3.12085477
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11579945
35	NADH dehydrogenase complex assembly (GO:0010257)	3.11579945
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11579945
37	indole-containing compound metabolic process (GO:0042430)	3.10578659
38	intraciliary transport (GO:0042073)	3.10157574
39	epithelial cilium movement (GO:0003351)	3.08987931
40	retinal rod cell development (GO:0046548)	3.06436362
41	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.05926858
42	neural tube formation (GO:0001841)	3.03507826
43	aldehyde catabolic process (GO:0046185)	3.03349364
44	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.01358878
45	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.01358878
46	regulation of translation, ncRNA-mediated (GO:0045974)	3.01358878
47	fucose catabolic process (GO:0019317)	3.01321013
48	L-fucose metabolic process (GO:0042354)	3.01321013
49	L-fucose catabolic process (GO:0042355)	3.01321013
50	negative regulation of multicellular organism growth (GO:0040015)	2.98861695
51	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.96920725
52	substrate-independent telencephalic tangential migration (GO:0021826)	2.96920725
53	glyoxylate metabolic process (GO:0046487)	2.93726236
54	photoreceptor cell maintenance (GO:0045494)	2.89522344
55	regulation of microtubule-based movement (GO:0060632)	2.88083371
56	striatum development (GO:0021756)	2.88075209
57	limb bud formation (GO:0060174)	2.85715862
58	respiratory chain complex IV assembly (GO:0008535)	2.84096902
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.82988063
60	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.82482672
61	tryptophan catabolic process (GO:0006569)	2.82103918
62	indole-containing compound catabolic process (GO:0042436)	2.82103918
63	indolalkylamine catabolic process (GO:0046218)	2.82103918
64	synaptic transmission, cholinergic (GO:0007271)	2.81730942
65	quinone biosynthetic process (GO:1901663)	2.79210241
66	somite development (GO:0061053)	2.78966576
67	response to pheromone (GO:0019236)	2.77510964
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75901205
69	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.75573770
70	mechanosensory behavior (GO:0007638)	2.72938073
71	regulation of meiosis I (GO:0060631)	2.72144332
72	piRNA metabolic process (GO:0034587)	2.71405255
73	lactate metabolic process (GO:0006089)	2.70020461
74	parental behavior (GO:0060746)	2.69381320
75	protein-cofactor linkage (GO:0018065)	2.69375615
76	positive regulation of meiotic cell cycle (GO:0051446)	2.68673162
77	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.66191043
78	positive regulation of meiosis (GO:0045836)	2.64318233
79	photoreceptor cell development (GO:0042461)	2.61771555
80	auditory behavior (GO:0031223)	2.61609115
81	cilium organization (GO:0044782)	2.60251552
82	C4-dicarboxylate transport (GO:0015740)	2.59644818
83	protein K11-linked deubiquitination (GO:0035871)	2.58853809
84	synapsis (GO:0007129)	2.57126316
85	kidney morphogenesis (GO:0060993)	2.55410327
86	cilium assembly (GO:0042384)	2.52150627
87	eye photoreceptor cell development (GO:0042462)	2.52019894
88	alanine transport (GO:0032328)	2.51706080
89	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.50596662
90	alkaloid metabolic process (GO:0009820)	2.50416378
91	cilium movement (GO:0003341)	2.47570400
92	neuron cell-cell adhesion (GO:0007158)	2.45836241
93	dendritic spine morphogenesis (GO:0060997)	2.45668677
94	retinal ganglion cell axon guidance (GO:0031290)	2.44319663
95	negative regulation of telomere maintenance (GO:0032205)	2.44034707
96	regulation of telomere maintenance (GO:0032204)	2.42749812
97	tryptophan metabolic process (GO:0006568)	2.41806227
98	prenylation (GO:0097354)	2.41069385
99	protein prenylation (GO:0018342)	2.41069385
100	DNA methylation involved in gamete generation (GO:0043046)	2.40810805

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.07222964
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00208970
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76471101
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.74627899
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68316795
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.62873837
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59135928
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52699283
9	VDR_22108803_ChIP-Seq_LS180_Human	2.47623770
10	FUS_26573619_Chip-Seq_HEK293_Human	2.42552436
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36036608
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30764091
13	P300_19829295_ChIP-Seq_ESCs_Human	2.16232631
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.09666585
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.06576398
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05357390
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.04684476
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94988738
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.87971647
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81021988
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80278177
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76951691
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73975965
24	EWS_26573619_Chip-Seq_HEK293_Human	1.73393543
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72883425
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68894954
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68754625
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.68119096
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66754175
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.66399435
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65806024
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64684670
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59694947
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59053318
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57073789
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.56845897
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56394887
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55973970
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55511807
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54257512
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53610629
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49685346
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.46719085
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45667765
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.45578672
46	AR_25329375_ChIP-Seq_VCAP_Human	1.45414841
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44334050
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.44138433
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43458342
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43190484
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.43190484
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42367519
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42296478
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42296478
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41600589
56	STAT3_23295773_ChIP-Seq_U87_Human	1.40842483
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40303333
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40107405
59	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.40055827
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39300768
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.38575941
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.37589313
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36129662
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36025214
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.34414948
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31567960
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31567960
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30743268
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.28382764
70	TCF4_23295773_ChIP-Seq_U87_Human	1.27919246
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25333326
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.25128093
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24184151
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23533967
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23500555
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21371862
77	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19167635
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.19153068
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18059381
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.17887328
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17779343
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17144747
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16278801
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14540388
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14164774
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13793298
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12909333
88	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11385026
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10645035
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09915657
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.09606802
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.08566371
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07958683
94	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.06811345
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04540795
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03485884
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.02512938
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01942903
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01942903
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01762525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.66996150
2	MP0001968_abnormal_touch/_nociception	2.90249058
3	MP0008877_abnormal_DNA_methylation	2.74478900
4	MP0002638_abnormal_pupillary_reflex	2.72448600
5	MP0002837_dystrophic_cardiac_calcinosis	2.53068965
6	MP0003787_abnormal_imprinting	2.45829816
7	MP0003121_genomic_imprinting	2.39417506
8	MP0001984_abnormal_olfaction	2.36171061
9	MP0003880_abnormal_central_pattern	2.34413371
10	MP0005551_abnormal_eye_electrophysiolog	2.24248281
11	MP0002163_abnormal_gland_morphology	2.19566183
12	MP0003646_muscle_fatigue	2.18748213
13	MP0006276_abnormal_autonomic_nervous	2.18625667
14	MP0000372_irregular_coat_pigmentation	2.14265201
15	MP0006072_abnormal_retinal_apoptosis	2.06372715
16	MP0005646_abnormal_pituitary_gland	2.03766959
17	MP0003123_paternal_imprinting	1.95912952
18	MP0000427_abnormal_hair_cycle	1.95883226
19	MP0003122_maternal_imprinting	1.89588502
20	MP0009046_muscle_twitch	1.82094742
21	MP0001529_abnormal_vocalization	1.79800155
22	MP0005379_endocrine/exocrine_gland_phen	1.77431637
23	MP0004742_abnormal_vestibular_system	1.77382602
24	MP0000778_abnormal_nervous_system	1.71397808
25	MP0005253_abnormal_eye_physiology	1.66132128
26	MP0001486_abnormal_startle_reflex	1.60776990
27	MP0005386_behavior/neurological_phenoty	1.53772921
28	MP0004924_abnormal_behavior	1.53772921
29	MP0005408_hypopigmentation	1.52324126
30	MP0005075_abnormal_melanosome_morpholog	1.51426532
31	MP0008872_abnormal_physiological_respon	1.50478335
32	MP0000538_abnormal_urinary_bladder	1.49587036
33	MP0003136_yellow_coat_color	1.46244130
34	MP0003195_calcinosis	1.45614958
35	MP0005389_reproductive_system_phenotype	1.43473122
36	MP0006054_spinal_hemorrhage	1.41219703
37	MP0000516_abnormal_urinary_system	1.40894305
38	MP0005367_renal/urinary_system_phenotyp	1.40894305
39	MP0002822_catalepsy	1.40073767
40	MP0010386_abnormal_urinary_bladder	1.39154542
41	MP0002735_abnormal_chemical_nociception	1.37920650
42	MP0004142_abnormal_muscle_tone	1.37163935
43	MP0008789_abnormal_olfactory_epithelium	1.36632748
44	MP0005499_abnormal_olfactory_system	1.35278148
45	MP0005394_taste/olfaction_phenotype	1.35278148
46	MP0004885_abnormal_endolymph	1.35151068
47	MP0009745_abnormal_behavioral_response	1.34958948
48	MP0001485_abnormal_pinna_reflex	1.34033721
49	MP0002160_abnormal_reproductive_system	1.31556930
50	MP0005084_abnormal_gallbladder_morpholo	1.31014988
51	MP0002938_white_spotting	1.30758007
52	MP0001905_abnormal_dopamine_level	1.29246769
53	MP0001502_abnormal_circadian_rhythm	1.29162261
54	MP0002734_abnormal_mechanical_nocicepti	1.26644194
55	MP0002572_abnormal_emotion/affect_behav	1.25911395
56	MP0002095_abnormal_skin_pigmentation	1.25891869
57	MP0001919_abnormal_reproductive_system	1.25856173
58	MP0009379_abnormal_foot_pigmentation	1.25365336
59	MP0008775_abnormal_heart_ventricle	1.25253865
60	MP0000631_abnormal_neuroendocrine_gland	1.24329860
61	MP0002272_abnormal_nervous_system	1.24010430
62	MP0002557_abnormal_social/conspecific_i	1.22199878
63	MP0003890_abnormal_embryonic-extraembry	1.20431786
64	MP0004147_increased_porphyrin_level	1.20011382
65	MP0008875_abnormal_xenobiotic_pharmacok	1.18523144
66	MP0002067_abnormal_sensory_capabilities	1.16947215
67	MP0001970_abnormal_pain_threshold	1.12928303
68	MP0005195_abnormal_posterior_eye	1.11976396
69	MP0002733_abnormal_thermal_nociception	1.11930532
70	MP0001501_abnormal_sleep_pattern	1.08834743
71	MP0002102_abnormal_ear_morphology	1.08407722
72	MP0003011_delayed_dark_adaptation	1.08313458
73	MP0001764_abnormal_homeostasis	1.08295029
74	MP0004133_heterotaxia	1.07714344
75	MP0000647_abnormal_sebaceous_gland	1.07581246
76	MP0005365_abnormal_bile_salt	1.06498390
77	MP0005410_abnormal_fertilization	1.06038646
78	MP0006292_abnormal_olfactory_placode	1.05751773
79	MP0004145_abnormal_muscle_electrophysio	1.01286254
80	MP0002254_reproductive_system_inflammat	0.99355814
81	MP0003786_premature_aging	0.97563532
82	MP0006035_abnormal_mitochondrial_morpho	0.95281349
83	MP0005174_abnormal_tail_pigmentation	0.94577319
84	MP0001324_abnormal_eye_pigmentation	0.93657650
85	MP0002064_seizures	0.92913461
86	MP0002752_abnormal_somatic_nervous	0.92423282
87	MP0002184_abnormal_innervation	0.92280781
88	MP0003635_abnormal_synaptic_transmissio	0.92017956
89	MP0002751_abnormal_autonomic_nervous	0.91284809
90	MP0002909_abnormal_adrenal_gland	0.89818136
91	MP0004270_analgesia	0.86251331
92	MP0003186_abnormal_redox_activity	0.85737811
93	MP0002876_abnormal_thyroid_physiology	0.85369565
94	MP0000015_abnormal_ear_pigmentation	0.84560280
95	MP0000026_abnormal_inner_ear	0.84068731
96	MP0002229_neurodegeneration	0.83985037
97	MP0000383_abnormal_hair_follicle	0.81966973
98	MP0008058_abnormal_DNA_repair	0.81658176
99	MP0002063_abnormal_learning/memory/cond	0.80584779
100	MP0008995_early_reproductive_senescence	0.77376295

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.37843598
2	Pancreatic fibrosis (HP:0100732)	3.45796138
3	3-Methylglutaconic aciduria (HP:0003535)	3.38328262
4	Abnormality of the labia minora (HP:0012880)	3.36466843
5	Acute necrotizing encephalopathy (HP:0006965)	3.32843261
6	True hermaphroditism (HP:0010459)	3.24275303
7	Progressive macrocephaly (HP:0004481)	3.24166625
8	Medial flaring of the eyebrow (HP:0010747)	3.21142752
9	Pancreatic cysts (HP:0001737)	3.13595878
10	Nephronophthisis (HP:0000090)	3.13386574
11	Volvulus (HP:0002580)	2.98464850
12	Acute encephalopathy (HP:0006846)	2.92868156
13	Congenital stationary night blindness (HP:0007642)	2.92181060
14	Oligodactyly (hands) (HP:0001180)	2.90642289
15	Abnormality of the renal medulla (HP:0100957)	2.88926604
16	Gait imbalance (HP:0002141)	2.88105004
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.85215717
18	Congenital primary aphakia (HP:0007707)	2.77415023
19	Molar tooth sign on MRI (HP:0002419)	2.76171358
20	Abnormality of midbrain morphology (HP:0002418)	2.76171358
21	Colon cancer (HP:0003003)	2.69417200
22	Megalencephaly (HP:0001355)	2.58047887
23	Nephrogenic diabetes insipidus (HP:0009806)	2.57755508
24	Hemiparesis (HP:0001269)	2.52124679
25	Mitochondrial inheritance (HP:0001427)	2.45773561
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.43715920
27	Decreased central vision (HP:0007663)	2.42437865
28	Neoplasm of the adrenal cortex (HP:0100641)	2.39873754
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35344918
30	Genital tract atresia (HP:0001827)	2.31474418
31	Cystic liver disease (HP:0006706)	2.29509705
32	Broad-based gait (HP:0002136)	2.29463822
33	Congenital sensorineural hearing impairment (HP:0008527)	2.27992919
34	Increased CSF lactate (HP:0002490)	2.27688571
35	Vaginal atresia (HP:0000148)	2.23739467
36	Stomach cancer (HP:0012126)	2.17864738
37	Attenuation of retinal blood vessels (HP:0007843)	2.17804029
38	Methylmalonic acidemia (HP:0002912)	2.17202514
39	Increased corneal curvature (HP:0100692)	2.16255552
40	Keratoconus (HP:0000563)	2.16255552
41	Abolished electroretinogram (ERG) (HP:0000550)	2.15337669
42	Pendular nystagmus (HP:0012043)	2.15253878
43	Widely spaced teeth (HP:0000687)	2.10130023
44	Abnormality of the renal cortex (HP:0011035)	2.05151346
45	Limb dystonia (HP:0002451)	2.04897659
46	Methylmalonic aciduria (HP:0012120)	2.03717032
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03659676
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00336971
49	Male pseudohermaphroditism (HP:0000037)	2.00007812
50	Abnormality of alanine metabolism (HP:0010916)	1.99588290
51	Hyperalaninemia (HP:0003348)	1.99588290
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.99588290
53	Drooling (HP:0002307)	1.99111416
54	Mesangial abnormality (HP:0001966)	1.96561845
55	Hyperglycinemia (HP:0002154)	1.93711892
56	Hypoplasia of the uterus (HP:0000013)	1.91571182
57	Sclerocornea (HP:0000647)	1.89791703
58	Small hand (HP:0200055)	1.89682311
59	Anencephaly (HP:0002323)	1.89364646
60	Optic disc pallor (HP:0000543)	1.89319974
61	Diastasis recti (HP:0001540)	1.89060009
62	Narrow forehead (HP:0000341)	1.88246982
63	Bifid tongue (HP:0010297)	1.87895796
64	Astigmatism (HP:0000483)	1.87033723
65	Postaxial hand polydactyly (HP:0001162)	1.85623108
66	Shawl scrotum (HP:0000049)	1.84788304
67	Oligodactyly (HP:0012165)	1.84778077
68	Congenital, generalized hypertrichosis (HP:0004540)	1.84074265
69	Constricted visual fields (HP:0001133)	1.81884796
70	Poor coordination (HP:0002370)	1.81216131
71	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79778593
72	Inability to walk (HP:0002540)	1.79554990
73	Absent speech (HP:0001344)	1.79212113
74	Intestinal atresia (HP:0011100)	1.79165517
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78878786
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78110226
77	Cerebral edema (HP:0002181)	1.77291452
78	Excessive salivation (HP:0003781)	1.76751757
79	Lipid accumulation in hepatocytes (HP:0006561)	1.76604914
80	Tented upper lip vermilion (HP:0010804)	1.74217098
81	Congenital hepatic fibrosis (HP:0002612)	1.73500558
82	Postaxial foot polydactyly (HP:0001830)	1.73045261
83	Hepatoblastoma (HP:0002884)	1.71125875
84	Short tibia (HP:0005736)	1.71121621
85	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70717944
86	Aganglionic megacolon (HP:0002251)	1.70491385
87	Hypoplastic pelvis (HP:0008839)	1.68531415
88	Cutaneous melanoma (HP:0012056)	1.68462065
89	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.64351148
90	Specific learning disability (HP:0001328)	1.64338558
91	X-linked dominant inheritance (HP:0001423)	1.64274040
92	Ectopic kidney (HP:0000086)	1.62455563
93	Decreased circulating renin level (HP:0003351)	1.61592182
94	Absent thumb (HP:0009777)	1.60918453
95	Supernumerary spleens (HP:0009799)	1.60646806
96	Thyroiditis (HP:0100646)	1.60460491
97	Retinitis pigmentosa (HP:0000510)	1.60429213
98	Febrile seizures (HP:0002373)	1.60208136
99	Optic nerve hypoplasia (HP:0000609)	1.60013389
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.59820036

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.86250377
2	CASK	3.84661066
3	BMPR1B	3.39275798
4	MAP4K2	2.71105613
5	WNK3	2.68104838
6	MAP3K12	2.47724417
7	NUAK1	2.43423016
8	PNCK	2.25653853
9	MAPK13	2.16932101
10	CSNK1G1	2.06505040
11	CCNB1	1.99328427
12	CSNK1G2	1.95850098
13	CSNK1G3	1.92931814
14	MKNK2	1.91637695
15	ADRBK2	1.90415547
16	FGFR2	1.88661276
17	ZAK	1.70093564
18	GRK1	1.68526699
19	OXSR1	1.64010074
20	STK16	1.60714622
21	PLK2	1.59978804
22	EPHA4	1.51234463
23	EPHB2	1.49337924
24	TNIK	1.48962755
25	PINK1	1.44701554
26	EIF2AK3	1.42789052
27	MAP3K4	1.38601306
28	NTRK3	1.28678612
29	PAK3	1.23736183
30	INSRR	1.14746902
31	MARK1	1.13542054
32	TAF1	1.05288927
33	PLK4	1.04071955
34	TAOK3	1.03812867
35	EIF2AK2	0.98970782
36	MAP2K7	0.98927919
37	NTRK2	0.98569793
38	VRK2	0.96525492
39	BCKDK	0.96359419
40	EIF2AK1	0.96249203
41	CSNK1A1L	0.94752772
42	TGFBR1	0.92849373
43	PRKCG	0.92588327
44	DYRK2	0.90811483
45	STK39	0.86460791
46	MKNK1	0.86429363
47	PDK2	0.83413741
48	ACVR1B	0.79969531
49	ROCK1	0.79335743
50	PHKG1	0.78937597
51	PHKG2	0.78937597
52	PRKCE	0.77995668
53	PLK3	0.76841056
54	PKN1	0.74497112
55	MYLK	0.70600169
56	WNK4	0.67397602
57	TLK1	0.66123792
58	ADRBK1	0.64876781
59	PLK1	0.64532669
60	PRKCI	0.63645780
61	MINK1	0.61379255
62	PIK3CG	0.60353745
63	PIK3CA	0.58757972
64	ILK	0.56852002
65	TIE1	0.55992899
66	NEK1	0.54260762
67	DMPK	0.54141816
68	MST4	0.53609253
69	PRKCQ	0.53100993
70	TRIM28	0.52499816
71	PRKCZ	0.49966490
72	WEE1	0.49935811
73	PTK2B	0.48873045
74	NEK2	0.48807400
75	NLK	0.46401703
76	VRK1	0.45640446
77	FGFR1	0.45346577
78	CSNK1A1	0.45252381
79	DYRK1A	0.44348593
80	CSNK1D	0.44104574
81	ATM	0.43493948
82	BUB1	0.43404099
83	NME1	0.42241805
84	PRKACA	0.40969559
85	CAMK1	0.40491479
86	SGK2	0.39927549
87	CAMK2A	0.39680636
88	TEC	0.39517033
89	PASK	0.38783367
90	BCR	0.38598880
91	STK38L	0.36699765
92	PRKCA	0.34929531
93	TNK2	0.32490911
94	MAP2K4	0.32107396
95	KSR1	0.31370794
96	ATR	0.30682445
97	CHEK2	0.30344411
98	ERBB3	0.30012833
99	CSNK1E	0.29977718
100	GSK3A	0.28833547

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.23162196
2	Phototransduction_Homo sapiens_hsa04744	2.95230496
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.72486707
4	Protein export_Homo sapiens_hsa03060	2.62615501
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.37775900
6	Parkinsons disease_Homo sapiens_hsa05012	2.28130148
7	Caffeine metabolism_Homo sapiens_hsa00232	2.12707390
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08027098
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05512957
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.04477933
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95436260
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95323831
13	Butanoate metabolism_Homo sapiens_hsa00650	1.94630746
14	Nicotine addiction_Homo sapiens_hsa05033	1.93955202
15	Basal transcription factors_Homo sapiens_hsa03022	1.84677897
16	Homologous recombination_Homo sapiens_hsa03440	1.84418536
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.65936501
18	Sulfur metabolism_Homo sapiens_hsa00920	1.64628608
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.63840348
20	RNA polymerase_Homo sapiens_hsa03020	1.58983102
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54226963
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.53732612
23	RNA degradation_Homo sapiens_hsa03018	1.51380018
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51320214
25	Proteasome_Homo sapiens_hsa03050	1.48724508
26	Propanoate metabolism_Homo sapiens_hsa00640	1.45942669
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.44750355
28	Alzheimers disease_Homo sapiens_hsa05010	1.44423714
29	Huntingtons disease_Homo sapiens_hsa05016	1.41888350
30	Fatty acid elongation_Homo sapiens_hsa00062	1.40643248
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37128486
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33565786
33	Regulation of autophagy_Homo sapiens_hsa04140	1.32760209
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32007736
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30910959
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.29963250
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26088422
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21726126
39	Circadian rhythm_Homo sapiens_hsa04710	1.20574567
40	Glycerolipid metabolism_Homo sapiens_hsa00561	1.18794991
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18126673
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15853546
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.13339762
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10326451
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00842688
46	Amphetamine addiction_Homo sapiens_hsa05031	1.00313444
47	Peroxisome_Homo sapiens_hsa04146	0.98790037
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.96410282
49	Mineral absorption_Homo sapiens_hsa04978	0.94499401
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.94242722
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.91166438
52	Retinol metabolism_Homo sapiens_hsa00830	0.91021251
53	Olfactory transduction_Homo sapiens_hsa04740	0.90971518
54	Cocaine addiction_Homo sapiens_hsa05030	0.90453576
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89477329
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.86080775
57	Morphine addiction_Homo sapiens_hsa05032	0.85954905
58	Serotonergic synapse_Homo sapiens_hsa04726	0.84580697
59	Circadian entrainment_Homo sapiens_hsa04713	0.82691695
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82388456
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.81265220
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.80752027
63	Fatty acid degradation_Homo sapiens_hsa00071	0.78050821
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77203730
65	Metabolic pathways_Homo sapiens_hsa01100	0.71540651
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.71461364
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69032637
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67254070
69	Ribosome_Homo sapiens_hsa03010	0.67042308
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.66536688
71	Purine metabolism_Homo sapiens_hsa00230	0.57599698
72	GABAergic synapse_Homo sapiens_hsa04727	0.57470094
73	Insulin secretion_Homo sapiens_hsa04911	0.56885239
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56012748
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54653203
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54594141
77	Glutathione metabolism_Homo sapiens_hsa00480	0.54031150
78	Base excision repair_Homo sapiens_hsa03410	0.53818251
79	Salivary secretion_Homo sapiens_hsa04970	0.53698340
80	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48032081
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47447816
82	Tight junction_Homo sapiens_hsa04530	0.46216118
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45886141
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45711646
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45160181
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44799641
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44096732
88	ABC transporters_Homo sapiens_hsa02010	0.42885976
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40870643
90	Lysine degradation_Homo sapiens_hsa00310	0.40232281
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.38737778
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.38397391
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.36746254
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36248413
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.35121960
96	Axon guidance_Homo sapiens_hsa04360	0.34871513
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34526214
98	Asthma_Homo sapiens_hsa05310	0.33869440
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33466824
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32831841

RPS15AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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