ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	skeletal muscle adaptation (GO:0043501)	9.95970444
2	striated muscle atrophy (GO:0014891)	9.81191122
3	regulation of skeletal muscle contraction (GO:0014819)	8.73886331
4	muscle atrophy (GO:0014889)	8.51898723
5	negative regulation of muscle hypertrophy (GO:0014741)	8.45222068
6	skeletal muscle tissue regeneration (GO:0043403)	7.09808359
7	actin-myosin filament sliding (GO:0033275)	7.03462201
8	muscle filament sliding (GO:0030049)	7.03462201
9	negative regulation of skeletal muscle tissue development (GO:0048642)	6.47514915
10	response to muscle activity (GO:0014850)	6.19621148
11	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	5.92436702
12	actin-mediated cell contraction (GO:0070252)	5.71958051
13	DNA damage response, signal transduction resulting in transcription (GO:0042772)	5.33117803
14	motile cilium assembly (GO:0044458)	5.10283397
15	tongue development (GO:0043586)	5.01646813
16	cellular response to dexamethasone stimulus (GO:0071549)	4.56545744
17	striated muscle adaptation (GO:0014888)	4.49153439
18	cellular potassium ion homeostasis (GO:0030007)	4.43833343
19	response to activity (GO:0014823)	4.42473805
20	cell proliferation in forebrain (GO:0021846)	4.39242930
21	protein K6-linked ubiquitination (GO:0085020)	4.23919955
22	negative regulation of organelle assembly (GO:1902116)	4.21241039
23	protein polyglutamylation (GO:0018095)	4.19229333
24	response to dexamethasone (GO:0071548)	4.17408932
25	actin filament-based movement (GO:0030048)	3.92962502
26	artery development (GO:0060840)	3.70111854
27	regulation of DNA endoreduplication (GO:0032875)	3.67462833
28	myotube cell development (GO:0014904)	3.62337667
29	response to electrical stimulus (GO:0051602)	3.61551758
30	regulation of muscle hypertrophy (GO:0014743)	3.60360196
31	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.51320355
32	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.47664399
33	skeletal muscle contraction (GO:0003009)	3.43183554
34	muscle adaptation (GO:0043500)	3.42108276
35	regulation of centriole replication (GO:0046599)	3.41593075
36	skeletal muscle fiber development (GO:0048741)	3.34864835
37	regulation of DNA methylation (GO:0044030)	3.23011333
38	outer ear morphogenesis (GO:0042473)	3.18899909
39	viral transcription (GO:0019083)	3.12019202
40	muscle organ development (GO:0007517)	3.07621627
41	negative regulation of striated muscle tissue development (GO:0045843)	3.05739892
42	negative regulation of muscle tissue development (GO:1901862)	3.05682894
43	dentate gyrus development (GO:0021542)	3.02962376
44	regulation of gene expression by genetic imprinting (GO:0006349)	3.00749435
45	muscle structure development (GO:0061061)	3.00410539
46	heparin biosynthetic process (GO:0030210)	2.98523804
47	heparin metabolic process (GO:0030202)	2.98523804
48	translational termination (GO:0006415)	2.96104937
49	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.95157926
50	dorsal/ventral axis specification (GO:0009950)	2.94664804
51	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.92570831
52	response to testosterone (GO:0033574)	2.92117987
53	negative regulation of muscle organ development (GO:0048635)	2.91269897
54	regulation of mesoderm development (GO:2000380)	2.89803648
55	regulation of germinal center formation (GO:0002634)	2.88251893
56	dosage compensation (GO:0007549)	2.87846016
57	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.83882545
58	protein trimerization (GO:0070206)	2.81977154
59	cartilage morphogenesis (GO:0060536)	2.81367085
60	ribosomal small subunit biogenesis (GO:0042274)	2.75079856
61	translational elongation (GO:0006414)	2.73996259
62	striatum development (GO:0021756)	2.73159515
63	neuron fate determination (GO:0048664)	2.72903049
64	ovulation cycle (GO:0042698)	2.72817286
65	appendage development (GO:0048736)	2.71033293
66	limb development (GO:0060173)	2.71033293
67	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.68673401
68	regulation of cardioblast proliferation (GO:0003264)	2.66664810
69	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.66664810
70	limb bud formation (GO:0060174)	2.63398533
71	cerebral cortex radially oriented cell migration (GO:0021799)	2.63260004
72	pharyngeal system development (GO:0060037)	2.59415906
73	embryonic hindlimb morphogenesis (GO:0035116)	2.59087915
74	positive regulation of histone H3-K4 methylation (GO:0051571)	2.58936279
75	adult heart development (GO:0007512)	2.55324868
76	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.55021948
77	auditory behavior (GO:0031223)	2.53666464
78	muscle cell cellular homeostasis (GO:0046716)	2.52561755
79	negative regulation of fatty acid metabolic process (GO:0045922)	2.48921214
80	middle ear morphogenesis (GO:0042474)	2.45346246
81	muscle system process (GO:0003012)	2.45186656
82	dendritic spine morphogenesis (GO:0060997)	2.43771250
83	embryonic viscerocranium morphogenesis (GO:0048703)	2.43129518
84	white fat cell differentiation (GO:0050872)	2.42463807
85	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.42036464
86	regulation of histone H3-K9 methylation (GO:0051570)	2.38783690
87	regulation of neuroblast proliferation (GO:1902692)	2.38561971
88	regulation of relaxation of muscle (GO:1901077)	2.38464621
89	neuronal action potential propagation (GO:0019227)	2.37976138
90	otic vesicle formation (GO:0030916)	2.37355195
91	segment specification (GO:0007379)	2.37077014
92	developmental induction (GO:0031128)	2.36890680
93	cellular response to glucocorticoid stimulus (GO:0071385)	2.36701915
94	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.36218747
95	cardiovascular system development (GO:0072358)	2.36205778
96	lens fiber cell development (GO:0070307)	2.36113073
97	genetic imprinting (GO:0071514)	2.35054386
98	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.34686920
99	substrate-independent telencephalic tangential migration (GO:0021826)	2.34686920
100	response to gravity (GO:0009629)	10.7027804

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.01710317
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.96474777
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.95411539
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.20005455
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.83936719
6	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.80806143
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.80060764
8	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.72996087
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.70095629
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.69210037
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.66453823
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.61184086
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.57258319
14	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.51689087
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.36385407
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.31792864
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29232526
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.26805386
19	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.18237010
20	AR_21572438_ChIP-Seq_LNCaP_Human	2.13683545
21	FUS_26573619_Chip-Seq_HEK293_Human	2.11855040
22	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.05930380
23	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.05930380
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.04858420
25	EZH2_22144423_ChIP-Seq_EOC_Human	10.4116890
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.88446998
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.88360573
28	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.88124065
29	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.85988888
30	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.75153239
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.68666659
32	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.66198660
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.64426164
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51260932
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.47228459
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.46813320
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.42982738
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.38725884
39	P300_19829295_ChIP-Seq_ESCs_Human	1.38278682
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34035253
41	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.33972161
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26249254
43	SOX9_26525672_Chip-Seq_HEART_Mouse	1.26074835
44	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.24227656
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22816912
46	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.21871958
47	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.18827163
48	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.18827163
49	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.18827163
50	EWS_26573619_Chip-Seq_HEK293_Human	1.11144892
51	RXR_22108803_ChIP-Seq_LS180_Human	1.10827296
52	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.10143586
53	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.09655460
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09627998
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08949336
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08410846
57	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07632061
58	KDM2B_26808549_Chip-Seq_REH_Human	1.06387947
59	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.05459272
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04956172
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03844149
62	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03610526
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01204469
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.01204469
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01193411
66	ER_23166858_ChIP-Seq_MCF-7_Human	0.98679124
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94979975
68	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94443227
69	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91273184
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90173590
71	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.89091532
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.88679073
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.88469557
74	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.88353732
75	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.86741471
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.85208901
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85145584
78	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.84581377
79	TP53_18474530_ChIP-ChIP_U2OS_Human	0.84448504
80	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.84328394
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.84044811
82	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.83810332
83	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.83615595
84	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.83183174
85	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.82604299
86	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.82598003
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82598003
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82544915
89	STAT3_23295773_ChIP-Seq_U87_Human	0.82230503
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.80571480
91	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.79472190
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.79423259
93	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.78566803
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.77901103
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77070913
96	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.76920502
97	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.75556332
98	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.75446181
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.75202856
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.73261755

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	4.30796440
2	MP0000747_muscle_weakness	3.57895374
3	MP0003705_abnormal_hypodermis_morpholog	3.53709591
4	MP0006292_abnormal_olfactory_placode	3.45840070
5	MP0002089_abnormal_postnatal_growth/wei	3.19731286
6	MP0000049_abnormal_middle_ear	2.59793386
7	MP0010030_abnormal_orbit_morphology	2.49663860
8	MP0004036_abnormal_muscle_relaxation	2.47929925
9	MP0000566_synostosis	2.39606486
10	MP0008789_abnormal_olfactory_epithelium	2.37225327
11	MP0002269_muscular_atrophy	2.34960240
12	MP0000759_abnormal_skeletal_muscle	2.29777337
13	MP0000749_muscle_degeneration	2.14014645
14	MP0002108_abnormal_muscle_morphology	2.02611557
15	MP0003937_abnormal_limbs/digits/tail_de	1.97501403
16	MP0000613_abnormal_salivary_gland	1.95281531
17	MP0004885_abnormal_endolymph	1.94293851
18	MP0004134_abnormal_chest_morphology	1.87952610
19	MP0009250_abnormal_appendicular_skeleto	1.85988361
20	MP0005083_abnormal_biliary_tract	1.81559366
21	MP0000678_abnormal_parathyroid_gland	1.76715537
22	MP0000427_abnormal_hair_cycle	1.74825065
23	MP0002106_abnormal_muscle_physiology	1.72572305
24	MP0005620_abnormal_muscle_contractility	1.67633366
25	MP0003755_abnormal_palate_morphology	1.66380607
26	MP0006072_abnormal_retinal_apoptosis	1.66073679
27	MP0002234_abnormal_pharynx_morphology	1.64657116
28	MP0005394_taste/olfaction_phenotype	1.63491854
29	MP0005499_abnormal_olfactory_system	1.63491854
30	MP0004087_abnormal_muscle_fiber	1.58650248
31	MP0001968_abnormal_touch/_nociception	1.53198235
32	MP0000631_abnormal_neuroendocrine_gland	1.50027621
33	MP0005248_abnormal_Harderian_gland	1.49512897
34	MP0000762_abnormal_tongue_morphology	1.47088328
35	MP0000428_abnormal_craniofacial_morphol	1.46545737
36	MP0000733_abnormal_muscle_development	1.43819387
37	MP0002736_abnormal_nociception_after	1.43780696
38	MP0005369_muscle_phenotype	1.42348189
39	MP0000750_abnormal_muscle_regeneration	1.34029085
40	MP0003938_abnormal_ear_development	1.32844055
41	MP0003123_paternal_imprinting	1.32169366
42	MP0003959_abnormal_lean_body	1.32150410
43	MP0002095_abnormal_skin_pigmentation	1.28191339
44	MP0002896_abnormal_bone_mineralization	1.26728138
45	MP0003136_yellow_coat_color	1.25292149
46	MP0003787_abnormal_imprinting	1.24448330
47	MP0000778_abnormal_nervous_system	1.22250508
48	MP0004133_heterotaxia	1.21904695
49	MP0003942_abnormal_urinary_system	1.21748736
50	MP0009379_abnormal_foot_pigmentation	1.21341661
51	MP0001293_anophthalmia	1.20274624
52	MP0002184_abnormal_innervation	1.14893509
53	MP0000372_irregular_coat_pigmentation	1.14651344
54	MP0000751_myopathy	1.14491878
55	MP0002177_abnormal_outer_ear	1.12396934
56	MP0002116_abnormal_craniofacial_bone	1.10909722
57	MP0003119_abnormal_digestive_system	1.09429331
58	MP0005187_abnormal_penis_morphology	1.07798360
59	MP0002249_abnormal_larynx_morphology	1.07135289
60	MP0003935_abnormal_craniofacial_develop	1.05968322
61	MP0003890_abnormal_embryonic-extraembry	1.04778434
62	MP0000534_abnormal_ureter_morphology	1.04147311
63	MP0003385_abnormal_body_wall	1.02940458
64	MP0002160_abnormal_reproductive_system	1.02846000
65	MP0004270_analgesia	1.00307641
66	MP0003122_maternal_imprinting	0.97861464
67	MP0002102_abnormal_ear_morphology	0.97572674
68	MP0002109_abnormal_limb_morphology	0.97006637
69	MP0001485_abnormal_pinna_reflex	0.96121267
70	MP0000163_abnormal_cartilage_morphology	0.94688180
71	MP0004233_abnormal_muscle_weight	0.93803190
72	MP0002638_abnormal_pupillary_reflex	0.92009298
73	MP0009780_abnormal_chondrocyte_physiolo	0.90149058
74	MP0002114_abnormal_axial_skeleton	0.89679792
75	MP0009053_abnormal_anal_canal	0.89231839
76	MP0000647_abnormal_sebaceous_gland	0.87464633
77	MP0002233_abnormal_nose_morphology	0.86843900
78	MP0009745_abnormal_behavioral_response	0.86330484
79	MP0000026_abnormal_inner_ear	0.86123630
80	MP0001486_abnormal_startle_reflex	0.84141070
81	MP0003936_abnormal_reproductive_system	0.84048255
82	MP0003121_genomic_imprinting	0.83852390
83	MP0001879_abnormal_lymphatic_vessel	0.82257198
84	MP0001340_abnormal_eyelid_morphology	0.82068472
85	MP0010307_abnormal_tumor_latency	0.80893104
86	MP0002115_abnormal_skeleton_extremities	0.80662202
87	MP0004859_abnormal_synaptic_plasticity	0.80035107
88	MP0001919_abnormal_reproductive_system	0.77204826
89	MP0002734_abnormal_mechanical_nocicepti	0.77073591
90	MP0003879_abnormal_hair_cell	0.76334772
91	MP0003646_muscle_fatigue	0.76128949
92	MP0003861_abnormal_nervous_system	0.76006372
93	MP0002277_abnormal_respiratory_mucosa	0.75928680
94	MP0005389_reproductive_system_phenotype	0.75839124
95	MP0003283_abnormal_digestive_organ	0.74434085
96	MP0000432_abnormal_head_morphology	0.71088208
97	MP0005409_darkened_coat_color	0.69842803
98	MP0002282_abnormal_trachea_morphology	0.67554707
99	MP0002067_abnormal_sensory_capabilities	0.65712708
100	MP0002272_abnormal_nervous_system	0.65602632

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	6.98746278
2	Mask-like facies (HP:0000298)	5.44482281
3	Conjunctival hamartoma (HP:0100780)	4.63694127
4	Nemaline bodies (HP:0003798)	4.60044825
5	Round ear (HP:0100830)	4.51255732
6	Exercise-induced myalgia (HP:0003738)	4.50966703
7	Calcaneovalgus deformity (HP:0001848)	4.50570570
8	Distal arthrogryposis (HP:0005684)	4.41273702
9	Absent phalangeal crease (HP:0006109)	4.01656295
10	Deformed tarsal bones (HP:0008119)	3.92926876
11	Ulnar deviation of the wrist (HP:0003049)	3.81247729
12	Septo-optic dysplasia (HP:0100842)	3.76934537
13	Muscle fiber inclusion bodies (HP:0100299)	3.62878140
14	Hyperkalemia (HP:0002153)	3.59435064
15	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.58244101
16	Colon cancer (HP:0003003)	3.54826774
17	Hamartoma of the eye (HP:0010568)	3.51614156
18	Neoplasm of the adrenal cortex (HP:0100641)	3.50681776
19	Bell-shaped thorax (HP:0001591)	3.43222727
20	Abnormal finger flexion creases (HP:0006143)	3.42135789
21	Periorbital edema (HP:0100539)	3.23901763
22	Meningioma (HP:0002858)	3.15169249
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.09054853
24	Facial edema (HP:0000282)	3.07074272
25	Fibular aplasia (HP:0002990)	3.02202434
26	Short 4th metacarpal (HP:0010044)	2.92617277
27	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.92617277
28	Hamartoma (HP:0010566)	2.85637975
29	Metatarsus adductus (HP:0001840)	2.81125065
30	Difficulty running (HP:0009046)	2.75822760
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.73634696
32	Type 1 muscle fiber predominance (HP:0003803)	2.68589580
33	Maternal diabetes (HP:0009800)	2.68513838
34	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.56764695
35	Hypoplastic pelvis (HP:0008839)	2.51339405
36	Abnormality of the 4th metacarpal (HP:0010012)	2.43264558
37	Myotonia (HP:0002486)	2.38844126
38	Cavernous hemangioma (HP:0001048)	2.32723760
39	Annular pancreas (HP:0001734)	2.29771411
40	Multiple lipomas (HP:0001012)	2.27931526
41	Myopathic facies (HP:0002058)	2.25053786
42	Fibroma (HP:0010614)	2.21967354
43	Abnormality of the calcaneus (HP:0008364)	2.18545351
44	Fibrous tissue neoplasm (HP:0012316)	2.16367802
45	Absent septum pellucidum (HP:0001331)	2.15582061
46	Decreased circulating renin level (HP:0003351)	2.15262961
47	Hypoplastic ischia (HP:0003175)	2.14423901
48	Down-sloping shoulders (HP:0200021)	2.14067156
49	Abnormality of the ischium (HP:0003174)	2.13615234
50	Short femoral neck (HP:0100864)	2.13125861
51	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.08868798
52	Hepatoblastoma (HP:0002884)	2.07948981
53	Optic nerve hypoplasia (HP:0000609)	2.06312272
54	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.05244845
55	Poor eye contact (HP:0000817)	2.04364477
56	Bone cyst (HP:0012062)	2.02476133
57	Mesomelia (HP:0003027)	2.02306497
58	Abnormality of potassium homeostasis (HP:0011042)	2.01781700
59	Abnormality of the septum pellucidum (HP:0007375)	2.01337286
60	Asplenia (HP:0001746)	2.01189495
61	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.97129199
62	Myoglobinuria (HP:0002913)	1.93716935
63	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92285983
64	Supernumerary ribs (HP:0005815)	1.92061296
65	Exercise-induced muscle cramps (HP:0003710)	1.89690523
66	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.89616066
67	Adenoma sebaceum (HP:0009720)	1.89412424
68	Angiofibromas (HP:0010615)	1.89412424
69	Medulloblastoma (HP:0002885)	1.87021062
70	Aplasia involving bones of the extremities (HP:0009825)	1.86586876
71	Aplasia involving bones of the upper limbs (HP:0009823)	1.86586876
72	Aplasia of the phalanges of the hand (HP:0009802)	1.86586876
73	Abnormality of abdominal situs (HP:0011620)	1.85482870
74	Abdominal situs inversus (HP:0003363)	1.85482870
75	Adrenal hypoplasia (HP:0000835)	1.84938281
76	Obstructive sleep apnea (HP:0002870)	1.83929862
77	Subacute progressive viral hepatitis (HP:0006572)	1.83656964
78	Lower limb asymmetry (HP:0100559)	1.81425780
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.81246442
80	Microglossia (HP:0000171)	1.80378148
81	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.79133738
82	Benign neoplasm of the central nervous system (HP:0100835)	1.77752407
83	Stomach cancer (HP:0012126)	1.76955183
84	Rectal prolapse (HP:0002035)	1.76750293
85	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.75886042
86	Severe visual impairment (HP:0001141)	1.75578208
87	Febrile seizures (HP:0002373)	1.75192224
88	Tarsal synostosis (HP:0008368)	1.74983990
89	Supernumerary bones of the axial skeleton (HP:0009144)	1.73112932
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72711633
91	2-3 toe syndactyly (HP:0004691)	1.72171178
92	Goiter (HP:0000853)	1.71407225
93	Action tremor (HP:0002345)	1.70379638
94	Muscle stiffness (HP:0003552)	1.70215193
95	Furrowed tongue (HP:0000221)	1.69518357
96	Intellectual disability, moderate (HP:0002342)	1.69513724
97	Vitreoretinal degeneration (HP:0000655)	1.68793953
98	Macroorchidism (HP:0000053)	1.66041940
99	Abnormal number of erythroid precursors (HP:0012131)	1.66041618
100	Hypoplastic iliac wings (HP:0002866)	1.65233044

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	6.20248962
2	TAF1	3.38680311
3	TIE1	3.28144706
4	PHKG2	3.23288109
5	PHKG1	3.23288109
6	STK16	3.02034839
7	OBSCN	2.76391620
8	CASK	2.67825768
9	VRK2	2.66700312
10	WNK1	2.59688150
11	WNK4	2.56296262
12	NUAK1	2.39198152
13	CSNK1A1L	2.29482652
14	TYRO3	2.23564871
15	CSNK1G3	2.10765174
16	NEK9	2.10633798
17	CSNK1G1	1.91499222
18	CSNK1G2	1.85812040
19	TNIK	1.82726811
20	SMG1	1.80723375
21	EPHB2	1.64145343
22	CHEK2	1.59650314
23	STK39	1.57134497
24	CAMK1D	1.53168899
25	PRKD3	1.44996096
26	PIK3CA	1.36714395
27	AURKA	1.31625875
28	MKNK2	1.31453688
29	MAPK13	1.31289855
30	DMPK	1.30917042
31	CAMK1G	1.27467399
32	CAMKK2	1.25731775
33	WNK3	1.15988621
34	CCNB1	1.12040463
35	DYRK2	1.10706849
36	EPHA4	1.04617829
37	ZAK	1.00456291
38	FGFR2	0.94233296
39	DYRK1B	0.86514311
40	MELK	0.86052094
41	PLK4	0.79617439
42	LIMK1	0.79446896
43	CAMK2G	0.77745656
44	MAPK7	0.77215691
45	DDR2	0.76249765
46	MAP3K12	0.75257543
47	PINK1	0.72068938
48	PRKD2	0.69984011
49	PAK6	0.65020047
50	MAP3K11	0.62773453
51	VRK1	0.62254013
52	GRK5	0.61605542
53	CDK4	0.60391296
54	PKN1	0.59337597
55	ATR	0.54135848
56	NTRK3	0.52712384
57	MAPKAPK5	0.52225795
58	MUSK	0.51205310
59	NEK2	0.49295126
60	NTRK2	0.49128125
61	CDK8	0.48144329
62	SGK1	0.44744295
63	HIPK2	0.44366045
64	SGK223	0.43364412
65	SGK494	0.43364412
66	IRAK1	0.43272158
67	DYRK3	0.43152241
68	LRRK2	0.42819645
69	ADRBK2	0.41607821
70	STK11	0.40953628
71	ABL2	0.40573862
72	AKT2	0.39678906
73	MOS	0.39530218
74	FGFR1	0.38820172
75	JAK3	0.38124754
76	BCR	0.37731627
77	NLK	0.36307117
78	KSR1	0.36112647
79	MARK3	0.35708540
80	LATS1	0.35700770
81	CSNK1A1	0.34220550
82	CDK7	0.32571089
83	PRKACA	0.31615954
84	CDK15	0.31419168
85	ERN1	0.30686904
86	MAPK12	0.30564011
87	CAMKK1	0.28212059
88	CDK11A	0.26732330
89	CDK18	0.26595510
90	CAMK1	0.26048483
91	PRKCE	0.24849146
92	DAPK3	0.24653609
93	PRKG1	0.24107419
94	SGK2	0.23380085
95	ILK	0.22400728
96	CDK9	0.22114452
97	CDK14	0.22058909
98	MAP2K4	0.21630341
99	ACVR1B	0.21005031
100	RPS6KA3	0.19878988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.15238842
2	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	3.45874456
3	Tight junction_Homo sapiens_hsa04530	3.10080960
4	Basal cell carcinoma_Homo sapiens_hsa05217	3.06609102
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.92484773
6	Regulation of autophagy_Homo sapiens_hsa04140	2.63695154
7	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.56464549
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.31756831
9	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.28636276
10	Wnt signaling pathway_Homo sapiens_hsa04310	2.27772241
11	Caffeine metabolism_Homo sapiens_hsa00232	2.26420617
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.11719382
13	Gastric acid secretion_Homo sapiens_hsa04971	1.81182269
14	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.78677857
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.64538877
16	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.60095003
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.56539606
18	Insulin secretion_Homo sapiens_hsa04911	1.49976044
19	Renin secretion_Homo sapiens_hsa04924	1.39336207
20	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.36391747
21	Hippo signaling pathway_Homo sapiens_hsa04390	1.30262737
22	Melanoma_Homo sapiens_hsa05218	1.23355342
23	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.20553276
24	Circadian entrainment_Homo sapiens_hsa04713	1.19681908
25	RNA degradation_Homo sapiens_hsa03018	1.17470862
26	Adherens junction_Homo sapiens_hsa04520	1.17125060
27	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.16317472
28	Melanogenesis_Homo sapiens_hsa04916	1.13673157
29	Long-term potentiation_Homo sapiens_hsa04720	1.13568582
30	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.12005211
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.11814100
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.10415522
33	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.09741839
34	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.07825739
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06579217
36	Homologous recombination_Homo sapiens_hsa03440	1.05531033
37	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.04516253
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03782606
39	Cholinergic synapse_Homo sapiens_hsa04725	0.99193477
40	Morphine addiction_Homo sapiens_hsa05032	0.97052281
41	Olfactory transduction_Homo sapiens_hsa04740	0.96888424
42	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96303270
43	MAPK signaling pathway_Homo sapiens_hsa04010	0.93886039
44	Dopaminergic synapse_Homo sapiens_hsa04728	0.92201050
45	Alzheimers disease_Homo sapiens_hsa05010	0.90993039
46	Sulfur relay system_Homo sapiens_hsa04122	0.89923314
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87945511
48	Glioma_Homo sapiens_hsa05214	0.87382987
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.85649903
50	Oocyte meiosis_Homo sapiens_hsa04114	0.84578393
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.84172281
52	Salivary secretion_Homo sapiens_hsa04970	0.80890174
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80046051
54	Huntingtons disease_Homo sapiens_hsa05016	0.79651767
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78225687
56	Glucagon signaling pathway_Homo sapiens_hsa04922	0.77181023
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.74865669
58	Axon guidance_Homo sapiens_hsa04360	0.71735244
59	Basal transcription factors_Homo sapiens_hsa03022	0.71214631
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70829450
61	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.66807265
62	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.66692967
63	Long-term depression_Homo sapiens_hsa04730	0.66314953
64	mTOR signaling pathway_Homo sapiens_hsa04150	0.64092283
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.63085295
66	Pancreatic secretion_Homo sapiens_hsa04972	0.62038398
67	GABAergic synapse_Homo sapiens_hsa04727	0.60575128
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.59650395
69	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.59002960
70	AMPK signaling pathway_Homo sapiens_hsa04152	0.58919049
71	Estrogen signaling pathway_Homo sapiens_hsa04915	0.58885564
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58624918
73	Endometrial cancer_Homo sapiens_hsa05213	0.57507797
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.56970377
75	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.56794677
76	Nicotine addiction_Homo sapiens_hsa05033	0.56200080
77	Colorectal cancer_Homo sapiens_hsa05210	0.54999811
78	Mismatch repair_Homo sapiens_hsa03430	0.54089716
79	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52020067
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.51491470
81	Ras signaling pathway_Homo sapiens_hsa04014	0.50144297
82	Spliceosome_Homo sapiens_hsa03040	0.48555586
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42012180
84	Serotonergic synapse_Homo sapiens_hsa04726	0.39694521
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39661957
86	GnRH signaling pathway_Homo sapiens_hsa04912	0.39351161
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38831253
88	Proteoglycans in cancer_Homo sapiens_hsa05205	0.38788156
89	Parkinsons disease_Homo sapiens_hsa05012	0.37864440
90	Folate biosynthesis_Homo sapiens_hsa00790	0.35861029
91	Thyroid cancer_Homo sapiens_hsa05216	0.35840948
92	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.35010934
93	Pathways in cancer_Homo sapiens_hsa05200	0.34149578
94	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.34040536
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33476784
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.33439125
97	Circadian rhythm_Homo sapiens_hsa04710	0.33394491
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.33289440
99	Amphetamine addiction_Homo sapiens_hsa05031	0.33036413
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.32497190

RPS15AP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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