RPS15P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.82586731
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.52486982
3cytidine catabolic process (GO:0006216)5.44008153
4cytidine deamination (GO:0009972)5.44008153
5cytidine metabolic process (GO:0046087)5.44008153
6ribosomal small subunit assembly (GO:0000028)5.39225237
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10960728
8ATP synthesis coupled proton transport (GO:0015986)5.10960728
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89411803
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.60934327
11viral transcription (GO:0019083)4.29343084
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.20927712
13translational termination (GO:0006415)4.11459964
14electron transport chain (GO:0022900)3.84578267
15respiratory electron transport chain (GO:0022904)3.84106746
16positive regulation of prostaglandin secretion (GO:0032308)3.83363376
17translational elongation (GO:0006414)3.81726218
18protein complex biogenesis (GO:0070271)3.79035412
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72195029
20protein targeting to ER (GO:0045047)3.63956836
21cotranslational protein targeting to membrane (GO:0006613)3.63319084
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62545038
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.62545038
24NADH dehydrogenase complex assembly (GO:0010257)3.62545038
25protein neddylation (GO:0045116)3.58386923
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54898671
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54898671
28protein localization to endoplasmic reticulum (GO:0070972)3.51495145
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46194041
30mitochondrial respiratory chain complex assembly (GO:0033108)3.35957875
31cellular response to interleukin-15 (GO:0071350)3.33763274
32chaperone-mediated protein transport (GO:0072321)3.30897254
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.28542376
34positive thymic T cell selection (GO:0045059)3.25420875
35maturation of SSU-rRNA (GO:0030490)3.24770103
36ribosomal small subunit biogenesis (GO:0042274)3.24636072
37behavioral response to nicotine (GO:0035095)3.17441802
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.17024739
39regulation of chronic inflammatory response (GO:0002676)3.13138674
40metallo-sulfur cluster assembly (GO:0031163)3.08139629
41iron-sulfur cluster assembly (GO:0016226)3.08139629
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05784906
43cellular protein complex disassembly (GO:0043624)3.03978407
44positive regulation of calcium-mediated signaling (GO:0050850)3.03847527
45mast cell activation (GO:0045576)3.03710915
46positive regulation of T cell apoptotic process (GO:0070234)3.03361783
47viral life cycle (GO:0019058)3.03198102
48positive regulation of defense response to virus by host (GO:0002230)3.02285426
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01866246
50platelet dense granule organization (GO:0060155)3.00371153
51negative regulation by host of viral transcription (GO:0043922)2.99116583
52positive T cell selection (GO:0043368)2.98819693
53negative regulation of mast cell activation (GO:0033004)2.98184682
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.97897221
55protein-cofactor linkage (GO:0018065)2.97275894
56regulation of T cell mediated cytotoxicity (GO:0001914)2.95850152
57positive regulation of fatty acid transport (GO:2000193)2.95486548
58regulation of prostaglandin secretion (GO:0032306)2.94541887
59negative regulation of T cell apoptotic process (GO:0070233)2.94284163
60positive regulation of icosanoid secretion (GO:0032305)2.90282753
61ATP biosynthetic process (GO:0006754)2.89716505
62regulation of regulatory T cell differentiation (GO:0045589)2.88871993
63respiratory chain complex IV assembly (GO:0008535)2.88332973
64hydrogen ion transmembrane transport (GO:1902600)2.87022782
65mast cell activation involved in immune response (GO:0002279)2.85031898
66mast cell degranulation (GO:0043303)2.85031898
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83496005
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83218049
69actin nucleation (GO:0045010)2.79823480
70positive regulation of interleukin-8 secretion (GO:2000484)2.78879829
71cytochrome complex assembly (GO:0017004)2.77989399
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75453886
73translation (GO:0006412)2.74772436
74proton transport (GO:0015992)2.74185753
75regulation of activation of Janus kinase activity (GO:0010533)2.74090221
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.73548187
77translational initiation (GO:0006413)2.73392800
78hydrogen transport (GO:0006818)2.72466926
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71629132
80GPI anchor biosynthetic process (GO:0006506)2.70062633
81mannosylation (GO:0097502)2.67096072
82GTP biosynthetic process (GO:0006183)2.63797756
83pyrimidine nucleoside catabolic process (GO:0046135)2.63618277
84GPI anchor metabolic process (GO:0006505)2.61903552
85response to pheromone (GO:0019236)2.60930626
86positive regulation of cell killing (GO:0031343)2.60013218
87ribosomal large subunit biogenesis (GO:0042273)2.58423439
88immunoglobulin mediated immune response (GO:0016064)2.58185528
89negative T cell selection (GO:0043383)2.56397052
90sequestering of actin monomers (GO:0042989)2.55641990
91negative regulation of heart rate (GO:0010459)2.55493894
92positive regulation of interleukin-17 production (GO:0032740)2.54724731
93T cell receptor signaling pathway (GO:0050852)2.54584811
94response to interferon-beta (GO:0035456)2.54532456
95regulation of interleukin-8 secretion (GO:2000482)2.53988679
96response to interleukin-15 (GO:0070672)2.48256740
97regulation of B cell receptor signaling pathway (GO:0050855)2.48157453
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46901741
99indolalkylamine metabolic process (GO:0006586)2.46618019
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.44890397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.82396241
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33974815
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.51027985
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.19550058
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15790748
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94127114
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92755891
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91835698
9VDR_22108803_ChIP-Seq_LS180_Human2.59668150
10EZH2_22144423_ChIP-Seq_EOC_Human2.51289610
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43316026
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41401750
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.23550277
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20507590
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16581297
16ZNF274_21170338_ChIP-Seq_K562_Hela2.15336530
17VDR_23849224_ChIP-Seq_CD4+_Human2.07148889
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05754895
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05225231
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.01735511
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01348078
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82563044
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.82525063
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.72981711
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63510159
26FOXP3_21729870_ChIP-Seq_TREG_Human1.61138471
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58122604
28TP53_22573176_ChIP-Seq_HFKS_Human1.57160411
29GATA3_26560356_Chip-Seq_TH2_Human1.56559180
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55713112
31MYB_26560356_Chip-Seq_TH2_Human1.52782875
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47633641
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.47324300
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45617152
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.45478436
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42923406
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42843441
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40530280
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38908054
40TAF2_19829295_ChIP-Seq_ESCs_Human1.36853985
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36739952
42AR_20517297_ChIP-Seq_VCAP_Human1.35827546
43IGF1R_20145208_ChIP-Seq_DFB_Human1.34716252
44MYC_18940864_ChIP-ChIP_HL60_Human1.33936189
45NANOG_20526341_ChIP-Seq_ESCs_Human1.33236828
46BCL6_27268052_Chip-Seq_Bcells_Human1.31776844
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29826268
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28861062
49GATA3_27048872_Chip-Seq_THYMUS_Human1.28130762
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26899087
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.26899087
52ELK1_19687146_ChIP-ChIP_HELA_Human1.25550657
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24936032
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24610260
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24014712
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22319965
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20416862
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.18706441
59NCOR_22424771_ChIP-Seq_293T_Human1.18145361
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17863517
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17121451
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12891873
63CIITA_25753668_ChIP-Seq_RAJI_Human1.12260900
64P300_27268052_Chip-Seq_Bcells_Human1.12087642
65ERA_21632823_ChIP-Seq_H3396_Human1.11820005
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11818953
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.11373756
68HTT_18923047_ChIP-ChIP_STHdh_Human1.11099951
69NANOG_19829295_ChIP-Seq_ESCs_Human1.09291880
70SOX2_19829295_ChIP-Seq_ESCs_Human1.09291880
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.08544545
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08405186
73RUNX_20019798_ChIP-Seq_JUKART_Human1.08153132
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06940931
75ER_23166858_ChIP-Seq_MCF-7_Human1.06468280
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.06410313
77STAT1_20625510_ChIP-Seq_HELA_Human1.06092213
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05897545
79MYC_19829295_ChIP-Seq_ESCs_Human1.03621151
80CTCF_20526341_ChIP-Seq_ESCs_Human1.03389183
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03247839
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03112414
83ERG_20517297_ChIP-Seq_VCAP_Human1.02156521
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01920968
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01795637
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01261639
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01237114
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00878702
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99080729
90SPI1_23547873_ChIP-Seq_NB4_Human0.97836899
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97473727
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97470350
93IRF1_19129219_ChIP-ChIP_H3396_Human0.96519644
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96297100
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.95627778
96E2F1_20622854_ChIP-Seq_HELA_Human0.95326652
97RAC3_21632823_ChIP-Seq_H3396_Human0.94087851
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94012085
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93855553
100OCT4_20526341_ChIP-Seq_ESCs_Human0.92914729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.52282378
2MP0001835_abnormal_antigen_presentation3.27588301
3MP0009379_abnormal_foot_pigmentation2.75438327
4MP0002102_abnormal_ear_morphology2.67026862
5MP0009333_abnormal_splenocyte_physiolog2.58218889
6MP0009785_altered_susceptibility_to2.40058102
7MP0005646_abnormal_pituitary_gland2.29068495
8MP0002148_abnormal_hypersensitivity_rea2.21657123
9MP0001800_abnormal_humoral_immune2.21596968
10MP0001968_abnormal_touch/_nociception2.13701705
11MP0005000_abnormal_immune_tolerance2.09036751
12MP0002138_abnormal_hepatobiliary_system2.05422393
13MP0001873_stomach_inflammation2.04630317
14MP0003724_increased_susceptibility_to2.03975400
15MP0001905_abnormal_dopamine_level2.00055546
16MP0006292_abnormal_olfactory_placode1.97614714
17MP0004147_increased_porphyrin_level1.90824785
18MP0002723_abnormal_immune_serum1.88207519
19MP0005387_immune_system_phenotype1.83109680
20MP0001790_abnormal_immune_system1.83109680
21MP0008872_abnormal_physiological_respon1.83038508
22MP0003806_abnormal_nucleotide_metabolis1.82671384
23MP0002420_abnormal_adaptive_immunity1.71971073
24MP0003763_abnormal_thymus_physiology1.71394216
25MP0008875_abnormal_xenobiotic_pharmacok1.70805463
26MP0001819_abnormal_immune_cell1.69747074
27MP0002837_dystrophic_cardiac_calcinosis1.67793151
28MP0006072_abnormal_retinal_apoptosis1.65791898
29MP0000685_abnormal_immune_system1.61086645
30MP0005075_abnormal_melanosome_morpholog1.60953156
31MP0003646_muscle_fatigue1.60129552
32MP0002452_abnormal_antigen_presenting1.59833233
33MP0003866_abnormal_defecation1.58083690
34MP0002876_abnormal_thyroid_physiology1.56350541
35MP0005377_hearing/vestibular/ear_phenot1.56233558
36MP0003878_abnormal_ear_physiology1.56233558
37MP0005551_abnormal_eye_electrophysiolog1.52180954
38MP0005025_abnormal_response_to1.51682873
39MP0001986_abnormal_taste_sensitivity1.42484522
40MP0005645_abnormal_hypothalamus_physiol1.39065764
41MP0004142_abnormal_muscle_tone1.33409613
42MP0003436_decreased_susceptibility_to1.32207761
43MP0004145_abnormal_muscle_electrophysio1.29125449
44MP0000372_irregular_coat_pigmentation1.27887506
45MP0000716_abnormal_immune_system1.25991212
46MP0003786_premature_aging1.25696318
47MP0004885_abnormal_endolymph1.25686302
48MP0008995_early_reproductive_senescence1.23652623
49MP0010155_abnormal_intestine_physiology1.22863834
50MP0001661_extended_life_span1.19418055
51MP0006082_CNS_inflammation1.19171679
52MP0005389_reproductive_system_phenotype1.17841346
53MP0002398_abnormal_bone_marrow1.17600595
54MP0003195_calcinosis1.17039386
55MP0001764_abnormal_homeostasis1.14840758
56MP0001845_abnormal_inflammatory_respons1.13848126
57MP0001485_abnormal_pinna_reflex1.13111055
58MP0002095_abnormal_skin_pigmentation1.12896859
59MP0002736_abnormal_nociception_after1.10089645
60MP0002234_abnormal_pharynx_morphology1.09656208
61MP0002419_abnormal_innate_immunity1.09226450
62MP0001919_abnormal_reproductive_system1.07922054
63MP0006036_abnormal_mitochondrial_physio1.07344721
64MP0002933_joint_inflammation1.06733379
65MP0002166_altered_tumor_susceptibility1.06502074
66MP0002638_abnormal_pupillary_reflex1.00963066
67MP0008877_abnormal_DNA_methylation1.00953801
68MP0003880_abnormal_central_pattern0.99828226
69MP0008789_abnormal_olfactory_epithelium0.99765402
70MP0008469_abnormal_protein_level0.98398831
71MP0002405_respiratory_system_inflammati0.98060537
72MP0005253_abnormal_eye_physiology0.97762442
73MP0005636_abnormal_mineral_homeostasis0.97365559
74MP0009764_decreased_sensitivity_to0.96292924
75MP0006276_abnormal_autonomic_nervous0.95427407
76MP0002429_abnormal_blood_cell0.95276813
77MP0000689_abnormal_spleen_morphology0.94505815
78MP0002277_abnormal_respiratory_mucosa0.93077838
79MP0001765_abnormal_ion_homeostasis0.92518475
80MP0005360_urolithiasis0.92517888
81MP0009745_abnormal_behavioral_response0.92096614
82MP0010386_abnormal_urinary_bladder0.91395776
83MP0002722_abnormal_immune_system0.87947777
84MP0001501_abnormal_sleep_pattern0.86741468
85MP0002163_abnormal_gland_morphology0.86267382
86MP0002006_tumorigenesis0.86006147
87MP0009643_abnormal_urine_homeostasis0.85735568
88MP0002160_abnormal_reproductive_system0.85675576
89MP0005464_abnormal_platelet_physiology0.84221089
90MP0003011_delayed_dark_adaptation0.82772276
91MP0005410_abnormal_fertilization0.81035566
92MP0001970_abnormal_pain_threshold0.80506526
93MP0005085_abnormal_gallbladder_physiolo0.79632033
94MP0000703_abnormal_thymus_morphology0.79333814
95MP0002272_abnormal_nervous_system0.78651105
96MP0002909_abnormal_adrenal_gland0.77452550
97MP0001963_abnormal_hearing_physiology0.76619409
98MP0003787_abnormal_imprinting0.75422214
99MP0002735_abnormal_chemical_nociception0.75416471
100MP0002733_abnormal_thermal_nociception0.75303557

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.48439934
2Mitochondrial inheritance (HP:0001427)4.35140513
3Abnormal mitochondria in muscle tissue (HP:0008316)4.10768918
43-Methylglutaconic aciduria (HP:0003535)3.88728735
5Hepatocellular necrosis (HP:0001404)3.85541495
6Acute encephalopathy (HP:0006846)3.75517016
7Increased CSF lactate (HP:0002490)3.75509736
8Progressive macrocephaly (HP:0004481)3.69047091
9Hepatic necrosis (HP:0002605)3.37429533
10IgG deficiency (HP:0004315)3.32269245
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26980563
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26980563
13Hypoproteinemia (HP:0003075)3.26900912
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.24576755
15Increased hepatocellular lipid droplets (HP:0006565)3.23177130
16Increased intramyocellular lipid droplets (HP:0012240)3.19267239
17Elevated erythrocyte sedimentation rate (HP:0003565)3.11543447
18Pancreatic cysts (HP:0001737)3.07628606
19Molar tooth sign on MRI (HP:0002419)3.07484146
20Abnormality of midbrain morphology (HP:0002418)3.07484146
21Congenital stationary night blindness (HP:0007642)3.05151483
22Abolished electroretinogram (ERG) (HP:0000550)3.03817764
23Cerebral edema (HP:0002181)3.01932402
24T lymphocytopenia (HP:0005403)3.00581552
25Lipid accumulation in hepatocytes (HP:0006561)3.00042931
26Severe combined immunodeficiency (HP:0004430)2.91900232
27Abnormality of T cell number (HP:0011839)2.91534615
28Renal Fanconi syndrome (HP:0001994)2.87190495
29Abnormal rod and cone electroretinograms (HP:0008323)2.86318205
30Abnormality of the prostate (HP:0008775)2.80536823
31Pancreatic fibrosis (HP:0100732)2.78244313
32Aplastic anemia (HP:0001915)2.77981530
33Abnormality of cells of the erythroid lineage (HP:0012130)2.76822885
34Increased muscle lipid content (HP:0009058)2.69654058
35Attenuation of retinal blood vessels (HP:0007843)2.66333040
36Optic disc pallor (HP:0000543)2.65927663
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65301158
38Abnormality of alanine metabolism (HP:0010916)2.63536940
39Hyperalaninemia (HP:0003348)2.63536940
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63536940
41Increased serum lactate (HP:0002151)2.62682109
42Abnormal number of erythroid precursors (HP:0012131)2.59278978
43Lactic acidosis (HP:0003128)2.57858677
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57087166
45True hermaphroditism (HP:0010459)2.52773797
46Reticulocytopenia (HP:0001896)2.51229168
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48235319
48Abnormality of T cells (HP:0002843)2.34957520
49Thyroiditis (HP:0100646)2.32729196
50Abnormality of B cell number (HP:0010975)2.24790173
51Pendular nystagmus (HP:0012043)2.24243914
52Exertional dyspnea (HP:0002875)2.22860114
53Type II lissencephaly (HP:0007260)2.22293931
54Increased IgM level (HP:0003496)2.21119035
55Chronic diarrhea (HP:0002028)2.17021780
56Combined immunodeficiency (HP:0005387)2.16682548
57Constricted visual fields (HP:0001133)2.15446838
58Retinal dysplasia (HP:0007973)2.14010047
59Panhypogammaglobulinemia (HP:0003139)2.12035388
60Congenital, generalized hypertrichosis (HP:0004540)2.11889437
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.11261223
62Generalized aminoaciduria (HP:0002909)2.08256883
63Asplenia (HP:0001746)2.07413505
64Macrocytic anemia (HP:0001972)2.06389291
65Lethargy (HP:0001254)2.04869616
66Abnormality of eosinophils (HP:0001879)2.04624072
67Respiratory failure (HP:0002878)2.03570379
68Pallor (HP:0000980)2.02891692
69Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.02635182
70Recurrent cutaneous fungal infections (HP:0011370)2.02622386
71Chronic mucocutaneous candidiasis (HP:0002728)2.02622386
72Decreased central vision (HP:0007663)1.97334935
73Renal cortical cysts (HP:0000803)1.96506170
74B lymphocytopenia (HP:0010976)1.96032109
75Exercise intolerance (HP:0003546)1.95408998
76Myositis (HP:0100614)1.93317122
77Type 2 muscle fiber atrophy (HP:0003554)1.92344741
78Abnormality of the phalanges of the 5th finger (HP:0004213)1.92108355
79Encephalitis (HP:0002383)1.91778590
80Absent thumb (HP:0009777)1.90211873
81Hypomagnesemia (HP:0002917)1.89713691
82Nephronophthisis (HP:0000090)1.89147877
83Abnormality of DNA repair (HP:0003254)1.85250622
84Leukodystrophy (HP:0002415)1.83682763
85Hemoptysis (HP:0002105)1.83650125
86Abnormality of the renal cortex (HP:0011035)1.83324634
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.81773289
88Absent/shortened dynein arms (HP:0200106)1.81773289
89Abnormality of magnesium homeostasis (HP:0004921)1.81428630
90Stomatitis (HP:0010280)1.79578643
91Muscle fiber atrophy (HP:0100295)1.78284306
92Pulmonary infiltrates (HP:0002113)1.78204594
93Obstructive lung disease (HP:0006536)1.77616765
94Chronic obstructive pulmonary disease (HP:0006510)1.77616765
95Abnormal protein glycosylation (HP:0012346)1.77029870
96Abnormal glycosylation (HP:0012345)1.77029870
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77029870
98Abnormal protein N-linked glycosylation (HP:0012347)1.77029870
99Sclerocornea (HP:0000647)1.76457501
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.76119856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.46100758
2TLK13.86203744
3KDR3.66581706
4BCKDK3.46970534
5TESK22.83709156
6ADRBK22.65813838
7MAP4K12.61653112
8ZAK2.59368243
9GRK12.44002844
10VRK22.40716090
11WNK42.02791855
12NUAK12.00530095
13TAOK31.95483648
14MAP3K121.87742334
15STK161.86646736
16MAP4K21.79487641
17FES1.78265801
18CDK191.77586216
19ITK1.77245646
20SCYL21.70101280
21TEC1.65733397
22SYK1.55768726
23BMPR1B1.45114831
24TIE11.43950716
25TNK21.42178565
26FRK1.29455354
27CDK81.25554219
28BTK1.25322847
29LIMK11.23764342
30PRKCQ1.23547313
31GRK61.20135332
32KIT1.17830333
33VRK11.17339112
34MYLK1.12692061
35MAPKAPK31.05049879
36LYN1.04448118
37BMPR21.04116304
38CSF1R1.04023948
39IKBKB1.02709776
40PINK11.00906551
41LCK0.99593077
42MST40.93677223
43IKBKE0.88528015
44TBK10.87623284
45MUSK0.87495848
46OXSR10.85701401
47INSRR0.85639964
48MAP3K110.84658866
49STK390.84369381
50DAPK10.83872604
51ADRBK10.82069249
52PDK20.80913029
53NME10.78588195
54GRK70.78377802
55NME20.78357166
56RPS6KA50.73036195
57TESK10.71399921
58JAK30.71120602
59WNK30.70918211
60OBSCN0.69943601
61DYRK20.68810762
62CSNK1G30.65647202
63ZAP700.64708014
64PHKG20.58632193
65PHKG10.58632193
66MAPK130.56615221
67PIK3CA0.56550564
68LRRK20.56221780
69DAPK30.55632003
70PIK3CG0.55534872
71BUB10.54208930
72MAPKAPK50.51438403
73GRK50.49988098
74MAP2K60.49753514
75CSNK1G20.49117878
76PRKCA0.45104191
77IGF1R0.44154306
78MAP2K20.43740778
79PRKACA0.43323137
80PIM10.40031389
81TGFBR10.39983331
82CSNK1A1L0.39210443
83ABL10.39032627
84AURKA0.38037363
85HCK0.37980638
86ABL20.37961538
87PASK0.37463930
88CSNK1A10.36956702
89RPS6KA40.36635693
90CSK0.36579677
91ILK0.35100196
92PIM20.34681025
93CSNK2A10.32520948
94MAP3K140.32022562
95CSNK1G10.31600093
96CSNK2A20.30451881
97ATR0.29746126
98CAMK10.28923319
99MARK30.28634007
100FYN0.28618574

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.70122167
2Oxidative phosphorylation_Homo sapiens_hsa001903.55794741
3Graft-versus-host disease_Homo sapiens_hsa053323.36104087
4Asthma_Homo sapiens_hsa053103.34110617
5Allograft rejection_Homo sapiens_hsa053303.32613028
6Autoimmune thyroid disease_Homo sapiens_hsa053203.30972328
7Primary immunodeficiency_Homo sapiens_hsa053403.08542699
8Proteasome_Homo sapiens_hsa030503.00414604
9Parkinsons disease_Homo sapiens_hsa050122.98024619
10Type I diabetes mellitus_Homo sapiens_hsa049402.62481113
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.52370304
12Antigen processing and presentation_Homo sapiens_hsa046122.20871590
13Alzheimers disease_Homo sapiens_hsa050101.93271714
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89763396
15RNA polymerase_Homo sapiens_hsa030201.84101849
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80423313
17Rheumatoid arthritis_Homo sapiens_hsa053231.79640717
18Huntingtons disease_Homo sapiens_hsa050161.74259742
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69145516
20Hematopoietic cell lineage_Homo sapiens_hsa046401.67024845
21Linoleic acid metabolism_Homo sapiens_hsa005911.65614035
22Cardiac muscle contraction_Homo sapiens_hsa042601.58594904
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52494788
24Phototransduction_Homo sapiens_hsa047441.50428365
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44940534
26Homologous recombination_Homo sapiens_hsa034401.44689806
27Protein export_Homo sapiens_hsa030601.36508159
28Viral myocarditis_Homo sapiens_hsa054161.26689139
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20944183
30Sulfur relay system_Homo sapiens_hsa041221.15522241
31Staphylococcus aureus infection_Homo sapiens_hsa051501.11659078
32Nitrogen metabolism_Homo sapiens_hsa009101.02832945
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02493749
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97659620
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93667014
36One carbon pool by folate_Homo sapiens_hsa006700.93163536
37Caffeine metabolism_Homo sapiens_hsa002320.93044481
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92061630
39T cell receptor signaling pathway_Homo sapiens_hsa046600.91149024
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90614649
41Peroxisome_Homo sapiens_hsa041460.90293083
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90197101
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.86970533
44Pyrimidine metabolism_Homo sapiens_hsa002400.86307028
45Fanconi anemia pathway_Homo sapiens_hsa034600.85790206
46Arachidonic acid metabolism_Homo sapiens_hsa005900.83697030
47Tryptophan metabolism_Homo sapiens_hsa003800.80612198
48RNA degradation_Homo sapiens_hsa030180.80326072
49Collecting duct acid secretion_Homo sapiens_hsa049660.80111630
50Retinol metabolism_Homo sapiens_hsa008300.79436916
51Nucleotide excision repair_Homo sapiens_hsa034200.79316602
52Systemic lupus erythematosus_Homo sapiens_hsa053220.78677342
53Sulfur metabolism_Homo sapiens_hsa009200.75593297
54Purine metabolism_Homo sapiens_hsa002300.71839430
55Leishmaniasis_Homo sapiens_hsa051400.71398421
56Olfactory transduction_Homo sapiens_hsa047400.70761305
57Chemical carcinogenesis_Homo sapiens_hsa052040.70384405
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.68166240
59Butanoate metabolism_Homo sapiens_hsa006500.67215862
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66266513
61Regulation of autophagy_Homo sapiens_hsa041400.65504521
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62967768
63Ether lipid metabolism_Homo sapiens_hsa005650.61011075
64Mismatch repair_Homo sapiens_hsa034300.59227583
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58090639
66Fat digestion and absorption_Homo sapiens_hsa049750.52790860
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.52463552
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51419571
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51055853
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50786783
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49950585
72Basal transcription factors_Homo sapiens_hsa030220.48416196
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48191385
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47716885
75Metabolic pathways_Homo sapiens_hsa011000.47410370
76DNA replication_Homo sapiens_hsa030300.46740023
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46314386
78Morphine addiction_Homo sapiens_hsa050320.45140295
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43533451
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.43226718
81Nicotine addiction_Homo sapiens_hsa050330.42992290
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42359919
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.41921497
84Malaria_Homo sapiens_hsa051440.41541026
85Herpes simplex infection_Homo sapiens_hsa051680.40917249
86Phenylalanine metabolism_Homo sapiens_hsa003600.37136482
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35222556
88Propanoate metabolism_Homo sapiens_hsa006400.32871323
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.32730205
90Measles_Homo sapiens_hsa051620.31507353
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31057136
92Taste transduction_Homo sapiens_hsa047420.30470387
93Base excision repair_Homo sapiens_hsa034100.30157186
94Tyrosine metabolism_Homo sapiens_hsa003500.27344065
95Spliceosome_Homo sapiens_hsa030400.23771723
96Salmonella infection_Homo sapiens_hsa051320.23584978
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21459459
98Salivary secretion_Homo sapiens_hsa049700.19538743
99Tuberculosis_Homo sapiens_hsa051520.19100423
100African trypanosomiasis_Homo sapiens_hsa051430.18977928

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