ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	7.70536456
2	viral transcription (GO:0019083)	7.39992263
3	ribosomal small subunit assembly (GO:0000028)	7.38805303
4	translational termination (GO:0006415)	7.05887328
5	translational elongation (GO:0006414)	5.90586710
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.90404593
7	protein targeting to ER (GO:0045047)	5.82894832
8	cotranslational protein targeting to membrane (GO:0006613)	5.81546811
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.53324771
10	protein localization to endoplasmic reticulum (GO:0070972)	5.51078771
11	maturation of SSU-rRNA (GO:0030490)	5.47883165
12	viral life cycle (GO:0019058)	5.36215552
13	ATP synthesis coupled proton transport (GO:0015986)	5.36022902
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.36022902
15	cellular protein complex disassembly (GO:0043624)	5.31361151
16	chaperone-mediated protein transport (GO:0072321)	5.22781177
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.07007998
18	translational initiation (GO:0006413)	4.81684707
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.68415442
20	protein neddylation (GO:0045116)	4.59364036
21	protein complex disassembly (GO:0043241)	4.58081263
22	auditory receptor cell differentiation (GO:0042491)	4.57649243
23	macromolecular complex disassembly (GO:0032984)	4.33262660
24	ncRNA 3-end processing (GO:0043628)	4.18965874
25	water-soluble vitamin biosynthetic process (GO:0042364)	4.13045953
26	response to pheromone (GO:0019236)	4.12525395
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.05742451
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.05742451
29	NADH dehydrogenase complex assembly (GO:0010257)	4.05742451
30	protein targeting to membrane (GO:0006612)	4.03045911
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.01494140
32	translation (GO:0006412)	3.96152247
33	ribonucleoprotein complex biogenesis (GO:0022613)	3.95191860
34	regulation of mitochondrial translation (GO:0070129)	3.93752058
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.93272248
36	protein complex biogenesis (GO:0070271)	3.90294658
37	cell proliferation in forebrain (GO:0021846)	3.86445750
38	behavioral response to nicotine (GO:0035095)	3.85154686
39	DNA deamination (GO:0045006)	3.84346409
40	cellular component biogenesis (GO:0044085)	3.79491102
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73560877
42	electron transport chain (GO:0022900)	3.54843701
43	respiratory electron transport chain (GO:0022904)	3.53946260
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.51266986
45	ribosomal large subunit biogenesis (GO:0042273)	3.49723296
46	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48200076
47	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.43189802
48	substrate-independent telencephalic tangential migration (GO:0021826)	3.43189802
49	nonmotile primary cilium assembly (GO:0035058)	3.41395734
50	respiratory chain complex IV assembly (GO:0008535)	3.40243265
51	cardiovascular system development (GO:0072358)	3.28359986
52	mRNA catabolic process (GO:0006402)	3.28332878
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26994026
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26994026
55	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.26207608
56	regulation of mitochondrial fission (GO:0090140)	3.11516585
57	L-fucose catabolic process (GO:0042355)	3.07100564
58	fucose catabolic process (GO:0019317)	3.07100564
59	L-fucose metabolic process (GO:0042354)	3.07100564
60	axoneme assembly (GO:0035082)	3.03373718
61	RNA catabolic process (GO:0006401)	3.01655773
62	UTP biosynthetic process (GO:0006228)	3.00844758
63	GTP biosynthetic process (GO:0006183)	3.00709772
64	establishment of mitochondrion localization (GO:0051654)	2.99591493
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.98852595
66	hydrogen ion transmembrane transport (GO:1902600)	2.98042896
67	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.94247344
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92811147
69	mechanosensory behavior (GO:0007638)	2.91622544
70	ubiquinone biosynthetic process (GO:0006744)	2.91614892
71	protein targeting (GO:0006605)	2.90457592
72	ATP biosynthetic process (GO:0006754)	2.90316845
73	cell migration in hindbrain (GO:0021535)	2.87712771
74	epithelial cilium movement (GO:0003351)	2.87645291
75	ribosome biogenesis (GO:0042254)	2.86535467
76	regulation of chromatin binding (GO:0035561)	2.86496841
77	parturition (GO:0007567)	2.86331085
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.82656807
79	positive regulation of cell fate commitment (GO:0010455)	2.81983536
80	detection of light stimulus involved in visual perception (GO:0050908)	2.81335556
81	detection of light stimulus involved in sensory perception (GO:0050962)	2.81335556
82	head development (GO:0060322)	2.81271506
83	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.79606096
84	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.78320235
85	myoblast migration (GO:0051451)	2.78294864
86	body morphogenesis (GO:0010171)	2.77349063
87	dorsal/ventral axis specification (GO:0009950)	2.75078327
88	ubiquinone metabolic process (GO:0006743)	2.73055546
89	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.72756346
90	cytochrome complex assembly (GO:0017004)	2.72709397
91	positive regulation of mitochondrial fission (GO:0090141)	2.71338225
92	protein targeting to mitochondrion (GO:0006626)	2.71294514
93	proton transport (GO:0015992)	2.70440938
94	genetic imprinting (GO:0071514)	2.70147807
95	establishment of protein localization to membrane (GO:0090150)	2.68425429
96	rRNA metabolic process (GO:0016072)	2.68357029
97	regulation of action potential (GO:0098900)	2.65696881
98	spinal cord association neuron differentiation (GO:0021527)	2.65386890
99	rRNA processing (GO:0006364)	2.64627327
100	male meiosis I (GO:0007141)	2.64399169

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.46766161
2	EZH2_22144423_ChIP-Seq_EOC_Human	6.23066924
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.64215302
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32432355
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.31345772
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72135247
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69980686
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.62015939
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53121291
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.44573335
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.28917011
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.20738539
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18512000
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.00164960
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.98327657
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94996541
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.90736022
18	VDR_22108803_ChIP-Seq_LS180_Human	1.89186106
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.74463763
20	GABP_19822575_ChIP-Seq_HepG2_Human	1.60534146
21	TTF2_22483619_ChIP-Seq_HELA_Human	1.57639050
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.56934268
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56144163
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.55369626
25	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.52533131
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50955718
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50902846
28	XRN2_22483619_ChIP-Seq_HELA_Human	1.48932808
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.45339696
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45314189
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45210961
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43309055
33	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.42853422
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40231502
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36920526
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35775970
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34548905
38	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.32304860
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30322922
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.30298217
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30246810
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.28288993
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.28102845
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.27131977
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27022917
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25850170
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25637234
48	ERA_21632823_ChIP-Seq_H3396_Human	1.25608369
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16223181
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14611209
51	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.14285679
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.13953609
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.13693794
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13047077
55	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12684612
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11781385
57	STAT1_20625510_ChIP-Seq_HELA_Human	1.11667181
58	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.08638053
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08482535
60	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.07959115
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06715951
62	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.05050272
63	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04953027
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04558115
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.04062599
66	EWS_26573619_Chip-Seq_HEK293_Human	1.02619078
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02205714
68	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.02071472
69	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.02071472
70	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.01785250
71	CTCF_27219007_Chip-Seq_Bcells_Human	1.00696968
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96217643
73	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.95306874
74	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95013485
75	BCL6_27268052_Chip-Seq_Bcells_Human	0.94972111
76	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94798494
77	P68_20966046_ChIP-Seq_HELA_Human	0.94097340
78	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.93324925
79	E2F1_20622854_ChIP-Seq_HELA_Human	0.92171022
80	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.91178928
81	SA1_27219007_Chip-Seq_Bcells_Human	0.90205371
82	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.89568641
83	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89361090
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87944066
85	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.87530739
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.86867073
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86730882
88	NCOR_22424771_ChIP-Seq_293T_Human	0.86329167
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.85993629
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.85961700
91	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.82727337
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.82708248
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.82553472
94	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.82455652
95	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.82356063
96	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.81692927
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.80873204
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.80293618
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.79645954
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.79588716

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.79197663
2	MP0006292_abnormal_olfactory_placode	4.53254658
3	MP0003787_abnormal_imprinting	4.14423262
4	MP0008877_abnormal_DNA_methylation	3.39420819
5	MP0002653_abnormal_ependyma_morphology	3.14444905
6	MP0001348_abnormal_lacrimal_gland	2.87665135
7	MP0003122_maternal_imprinting	2.37666434
8	MP0004145_abnormal_muscle_electrophysio	2.31478028
9	MP0003136_yellow_coat_color	2.25968964
10	MP0006276_abnormal_autonomic_nervous	2.19541241
11	MP0004142_abnormal_muscle_tone	2.18760733
12	MP0008875_abnormal_xenobiotic_pharmacok	2.11490222
13	MP0008789_abnormal_olfactory_epithelium	2.10184804
14	MP0003646_muscle_fatigue	2.07817884
15	MP0004742_abnormal_vestibular_system	2.06837781
16	MP0003123_paternal_imprinting	2.05456986
17	MP0003121_genomic_imprinting	2.01199520
18	MP0005645_abnormal_hypothalamus_physiol	2.00288289
19	MP0001485_abnormal_pinna_reflex	1.81029517
20	MP0001968_abnormal_touch/_nociception	1.76348073
21	MP0000778_abnormal_nervous_system	1.70701182
22	MP0001986_abnormal_taste_sensitivity	1.66435489
23	MP0002163_abnormal_gland_morphology	1.65460885
24	MP0008872_abnormal_physiological_respon	1.62030211
25	MP0002138_abnormal_hepatobiliary_system	1.61043935
26	MP0002102_abnormal_ear_morphology	1.60606941
27	MP0005394_taste/olfaction_phenotype	1.60340835
28	MP0005499_abnormal_olfactory_system	1.60340835
29	MP0002272_abnormal_nervous_system	1.59569420
30	MP0002557_abnormal_social/conspecific_i	1.56542834
31	MP0005551_abnormal_eye_electrophysiolog	1.51996429
32	MP0002938_white_spotting	1.50764010
33	MP0002184_abnormal_innervation	1.49373606
34	MP0000049_abnormal_middle_ear	1.49350627
35	MP0000631_abnormal_neuroendocrine_gland	1.48116318
36	MP0001873_stomach_inflammation	1.47366824
37	MP0003186_abnormal_redox_activity	1.45025761
38	MP0001293_anophthalmia	1.42002439
39	MP0004885_abnormal_endolymph	1.39479334
40	MP0001188_hyperpigmentation	1.39393349
41	MP0003567_abnormal_fetal_cardiomyocyte	1.39343255
42	MP0001984_abnormal_olfaction	1.37334101
43	MP0005423_abnormal_somatic_nervous	1.35237049
44	MP0008775_abnormal_heart_ventricle	1.25684966
45	MP0002752_abnormal_somatic_nervous	1.18845745
46	MP0004133_heterotaxia	1.16660491
47	MP0001970_abnormal_pain_threshold	1.15480403
48	MP0002733_abnormal_thermal_nociception	1.15140044
49	MP0000026_abnormal_inner_ear	1.14086603
50	MP0003878_abnormal_ear_physiology	1.13963936
51	MP0005377_hearing/vestibular/ear_phenot	1.13963936
52	MP0003938_abnormal_ear_development	1.13359743
53	MP0002067_abnormal_sensory_capabilities	1.13088465
54	MP0002736_abnormal_nociception_after	1.13058689
55	MP0001542_abnormal_bone_strength	1.12015362
56	MP0002160_abnormal_reproductive_system	1.09830017
57	MP0002095_abnormal_skin_pigmentation	1.06584810
58	MP0009745_abnormal_behavioral_response	1.05302566
59	MP0003880_abnormal_central_pattern	1.04683980
60	MP0002063_abnormal_learning/memory/cond	1.03945281
61	MP0001486_abnormal_startle_reflex	1.03831525
62	MP0000569_abnormal_digit_pigmentation	1.03085980
63	MP0000955_abnormal_spinal_cord	1.02774615
64	MP0001440_abnormal_grooming_behavior	1.02495343
65	MP0005174_abnormal_tail_pigmentation	1.01573043
66	MP0006072_abnormal_retinal_apoptosis	1.01386473
67	MP0001502_abnormal_circadian_rhythm	0.99061714
68	MP0005195_abnormal_posterior_eye	0.96871439
69	MP0001529_abnormal_vocalization	0.95108059
70	MP0008058_abnormal_DNA_repair	0.94045504
71	MP0002572_abnormal_emotion/affect_behav	0.93973766
72	MP0002882_abnormal_neuron_morphology	0.92833756
73	MP0002734_abnormal_mechanical_nocicepti	0.92659577
74	MP0003890_abnormal_embryonic-extraembry	0.91344908
75	MP0001663_abnormal_digestive_system	0.91093680
76	MP0005253_abnormal_eye_physiology	0.90759791
77	MP0002837_dystrophic_cardiac_calcinosis	0.90391857
78	MP0005379_endocrine/exocrine_gland_phen	0.90204959
79	MP0005084_abnormal_gallbladder_morpholo	0.89298753
80	MP0002234_abnormal_pharynx_morphology	0.89091163
81	MP0003879_abnormal_hair_cell	0.82958250
82	MP0002822_catalepsy	0.82282995
83	MP0001963_abnormal_hearing_physiology	0.80880356
84	MP0002210_abnormal_sex_determination	0.79923714
85	MP0009046_muscle_twitch	0.79600074
86	MP0003635_abnormal_synaptic_transmissio	0.79057239
87	MP0000372_irregular_coat_pigmentation	0.77872008
88	MP0002735_abnormal_chemical_nociception	0.77672085
89	MP0000427_abnormal_hair_cycle	0.76995067
90	MP0004043_abnormal_pH_regulation	0.76209253
91	MP0002229_neurodegeneration	0.75439148
92	MP0002064_seizures	0.74781134
93	MP0002152_abnormal_brain_morphology	0.73877942
94	MP0005389_reproductive_system_phenotype	0.72498353
95	MP0004858_abnormal_nervous_system	0.71508261
96	MP0001905_abnormal_dopamine_level	0.69528370
97	MP0000653_abnormal_sex_gland	0.67294887
98	MP0005075_abnormal_melanosome_morpholog	0.67217995
99	MP0002066_abnormal_motor_capabilities/c	0.65061450
100	MP0002277_abnormal_respiratory_mucosa	0.63767769

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.71264308
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.55493677
3	Acute necrotizing encephalopathy (HP:0006965)	4.44791064
4	Acute encephalopathy (HP:0006846)	4.29267253
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.04437966
6	Pancreatic cysts (HP:0001737)	3.81064360
7	Abnormal number of erythroid precursors (HP:0012131)	3.68205966
8	Progressive macrocephaly (HP:0004481)	3.67242900
9	Pancreatic fibrosis (HP:0100732)	3.65490559
10	Mitochondrial inheritance (HP:0001427)	3.51995840
11	Increased hepatocellular lipid droplets (HP:0006565)	3.50640053
12	Increased CSF lactate (HP:0002490)	3.41732606
13	Abnormality of midbrain morphology (HP:0002418)	3.39618849
14	Molar tooth sign on MRI (HP:0002419)	3.39618849
15	Hyperglycinemia (HP:0002154)	3.28026841
16	Septo-optic dysplasia (HP:0100842)	3.25205195
17	Macrocytic anemia (HP:0001972)	3.24240247
18	Methylmalonic acidemia (HP:0002912)	3.06594184
19	Polyphagia (HP:0002591)	3.03406466
20	Methylmalonic aciduria (HP:0012120)	3.01347839
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.99674308
22	Lipid accumulation in hepatocytes (HP:0006561)	2.98252043
23	Nephronophthisis (HP:0000090)	2.81800348
24	Porencephaly (HP:0002132)	2.81557298
25	Renal Fanconi syndrome (HP:0001994)	2.75770124
26	Rib fusion (HP:0000902)	2.63473204
27	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.63436847
28	Hyperthyroidism (HP:0000836)	2.62858515
29	Cerebral edema (HP:0002181)	2.56095212
30	Increased intramyocellular lipid droplets (HP:0012240)	2.55662867
31	Hypoplasia of the ulna (HP:0003022)	2.50560972
32	Pallor (HP:0000980)	2.49824142
33	Cleft eyelid (HP:0000625)	2.47021734
34	Abnormality of the labia minora (HP:0012880)	2.40638433
35	Optic disc pallor (HP:0000543)	2.39561924
36	Type II lissencephaly (HP:0007260)	2.38090123
37	Hepatocellular necrosis (HP:0001404)	2.37169172
38	Sclerocornea (HP:0000647)	2.36881745
39	Asplenia (HP:0001746)	2.35150738
40	Myokymia (HP:0002411)	2.33483042
41	Cystic liver disease (HP:0006706)	2.32987355
42	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29277332
43	Pendular nystagmus (HP:0012043)	2.29125438
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.28951136
45	Supernumerary bones of the axial skeleton (HP:0009144)	2.26132587
46	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.25413373
47	Tubular atrophy (HP:0000092)	2.23268091
48	Absent septum pellucidum (HP:0001331)	2.21962106
49	Medial flaring of the eyebrow (HP:0010747)	2.21772717
50	Abnormality of serine family amino acid metabolism (HP:0010894)	2.21656202
51	Abnormality of glycine metabolism (HP:0010895)	2.21656202
52	Hypoplasia of the radius (HP:0002984)	2.21515480
53	True hermaphroditism (HP:0010459)	2.17380824
54	Lethargy (HP:0001254)	2.15290354
55	Type 2 muscle fiber atrophy (HP:0003554)	2.13476699
56	Increased serum lactate (HP:0002151)	2.12806730
57	Horseshoe kidney (HP:0000085)	2.12555496
58	Respiratory difficulties (HP:0002880)	2.11350859
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11191032
60	3-Methylglutaconic aciduria (HP:0003535)	2.10834252
61	Hyperglycinuria (HP:0003108)	2.10045558
62	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.09179949
63	Oligodactyly (hands) (HP:0001180)	2.06796323
64	Lactic acidosis (HP:0003128)	2.06495079
65	Hypoplasia of the pons (HP:0012110)	2.06235483
66	Abnormal hair whorl (HP:0010721)	2.05843342
67	Abnormality of the renal medulla (HP:0100957)	2.05598012
68	Abnormality of magnesium homeostasis (HP:0004921)	2.04810532
69	Optic nerve hypoplasia (HP:0000609)	2.04466861
70	Posterior subcapsular cataract (HP:0007787)	2.04255419
71	Adactyly (HP:0009776)	2.03581091
72	Exertional dyspnea (HP:0002875)	2.03463722
73	Forearm undergrowth (HP:0009821)	2.03448550
74	Leukodystrophy (HP:0002415)	2.02237850
75	Abnormal eating behavior (HP:0100738)	2.02138350
76	Polydipsia (HP:0001959)	2.01980760
77	Abnormal drinking behavior (HP:0030082)	2.01980760
78	Congenital stationary night blindness (HP:0007642)	2.00819152
79	Exercise intolerance (HP:0003546)	2.00678912
80	Congenital, generalized hypertrichosis (HP:0004540)	1.99325899
81	Median cleft lip (HP:0000161)	1.98758781
82	Abnormality of the pons (HP:0007361)	1.97575562
83	Muscle fiber atrophy (HP:0100295)	1.96667706
84	Stenosis of the external auditory canal (HP:0000402)	1.96557747
85	Papilledema (HP:0001085)	1.96524932
86	Abnormality of the septum pellucidum (HP:0007375)	1.94599387
87	Supernumerary spleens (HP:0009799)	1.94369917
88	Pancytopenia (HP:0001876)	1.93363000
89	Narrow forehead (HP:0000341)	1.92648859
90	Colon cancer (HP:0003003)	1.92573289
91	Bile duct proliferation (HP:0001408)	1.92353186
92	Abnormal biliary tract physiology (HP:0012439)	1.92353186
93	Hepatic necrosis (HP:0002605)	1.90972822
94	Increased muscle lipid content (HP:0009058)	1.90804921
95	Abnormality of the renal cortex (HP:0011035)	1.90196735
96	Hypoplasia of the uterus (HP:0000013)	1.89123086
97	Cerebellar dysplasia (HP:0007033)	1.88850548
98	Chronic hepatic failure (HP:0100626)	1.88836021
99	Progressive microcephaly (HP:0000253)	1.87340549
100	Anencephaly (HP:0002323)	1.87096189

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	8.55945054
2	WNK4	3.52213250
3	TXK	2.94842138
4	ADRBK2	2.68057647
5	PBK	2.52012867
6	BCKDK	2.51280617
7	MAP4K1	2.24376676
8	PINK1	2.08126019
9	CDK19	1.99683150
10	PDK2	1.98580271
11	DYRK2	1.88414796
12	TNIK	1.77430631
13	NUAK1	1.75146559
14	GRK1	1.68706828
15	BMPR1B	1.66570342
16	TYRO3	1.50830748
17	LRRK2	1.45867314
18	STK39	1.44572971
19	DMPK	1.37361035
20	TIE1	1.37303301
21	EPHB2	1.29337793
22	PRKCG	1.23283613
23	VRK2	1.21333729
24	CAMK1	1.14574426
25	MAP2K7	1.13681653
26	NTRK2	1.12119187
27	CAMK1D	1.10541940
28	VRK1	1.08301537
29	PRKCH	1.06656197
30	OXSR1	1.03391530
31	EIF2AK1	1.02456666
32	TAF1	1.01333152
33	PIK3CA	0.98020212
34	NTRK3	0.97728952
35	NEK1	0.94250129
36	PAK3	0.93146846
37	ZAK	0.90304321
38	MAPK13	0.90285455
39	MINK1	0.87857543
40	AURKA	0.87115877
41	TLK1	0.85760508
42	MAP3K11	0.85105583
43	SIK2	0.81181156
44	CAMK1G	0.79730138
45	EPHA4	0.79146815
46	STK11	0.76703898
47	FRK	0.75560927
48	ADRBK1	0.75045204
49	MARK2	0.70923481
50	PRKD2	0.70908076
51	CSNK1E	0.69597561
52	TNK2	0.68748286
53	SRPK1	0.67865194
54	PRKCI	0.67395009
55	RPS6KA6	0.64973888
56	NME1	0.64215051
57	STK4	0.62548821
58	PRKCQ	0.61438466
59	NME2	0.59804170
60	CASK	0.58369700
61	PHKG1	0.58128908
62	PHKG2	0.58128908
63	NEK2	0.57345447
64	ABL2	0.57333582
65	PRKCZ	0.56402843
66	RPS6KC1	0.55767214
67	RPS6KL1	0.55767214
68	BTK	0.52623747
69	PRKACA	0.51880248
70	RPS6KA2	0.51010876
71	CSNK2A2	0.49219642
72	BCR	0.46171015
73	MAPK15	0.45206434
74	TAOK3	0.44583749
75	SGK1	0.44303585
76	DAPK3	0.41913918
77	CSNK1A1	0.41387197
78	MAP3K4	0.40400093
79	AURKB	0.40083622
80	CAMKK2	0.39495598
81	CSNK2A1	0.39337222
82	MKNK2	0.39110473
83	CHEK2	0.38800034
84	PRKCD	0.37958036
85	MAP3K9	0.37953874
86	MARK1	0.37866699
87	PRKDC	0.36170681
88	PLK1	0.35524185
89	PRKCE	0.35276889
90	STK3	0.35026176
91	SGK223	0.34249156
92	SGK494	0.34249156
93	CDC7	0.34102213
94	INSRR	0.32722882
95	PLK3	0.31969322
96	PRKACB	0.31489671
97	PASK	0.30835083
98	PRKCA	0.29374404
99	ITK	0.29357707
100	WNK3	0.28459168

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.57509937
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.40338262
3	Parkinsons disease_Homo sapiens_hsa05012	3.71882079
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.97399502
5	Sulfur relay system_Homo sapiens_hsa04122	2.82269274
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.80039748
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.75105364
8	Huntingtons disease_Homo sapiens_hsa05016	2.63069011
9	Alzheimers disease_Homo sapiens_hsa05010	2.41586652
10	Basal transcription factors_Homo sapiens_hsa03022	2.40170234
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.36058485
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32672004
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.95391043
14	Homologous recombination_Homo sapiens_hsa03440	1.93799319
15	Asthma_Homo sapiens_hsa05310	1.78032893
16	Protein export_Homo sapiens_hsa03060	1.67384878
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.65587858
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52897827
19	RNA polymerase_Homo sapiens_hsa03020	1.49933125
20	Phototransduction_Homo sapiens_hsa04744	1.44615098
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.43975791
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41008426
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.32248157
24	RNA degradation_Homo sapiens_hsa03018	1.28339024
25	Propanoate metabolism_Homo sapiens_hsa00640	1.25717799
26	Folate biosynthesis_Homo sapiens_hsa00790	1.25381534
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22672813
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22206288
29	Allograft rejection_Homo sapiens_hsa05330	1.11583195
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.08483097
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01845002
32	Mismatch repair_Homo sapiens_hsa03430	1.00918449
33	RNA transport_Homo sapiens_hsa03013	0.97165535
34	Regulation of autophagy_Homo sapiens_hsa04140	0.94069263
35	Sulfur metabolism_Homo sapiens_hsa00920	0.93008307
36	Proteasome_Homo sapiens_hsa03050	0.92309798
37	Nicotine addiction_Homo sapiens_hsa05033	0.90834195
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89423230
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87555875
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85356055
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84729893
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.81381238
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79119473
44	One carbon pool by folate_Homo sapiens_hsa00670	0.78475073
45	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.75144752
46	Butanoate metabolism_Homo sapiens_hsa00650	0.75105645
47	Peroxisome_Homo sapiens_hsa04146	0.74867607
48	Metabolic pathways_Homo sapiens_hsa01100	0.73905498
49	Caffeine metabolism_Homo sapiens_hsa00232	0.72251761
50	Base excision repair_Homo sapiens_hsa03410	0.71973567
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70578413
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69582314
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69364982
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65915195
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64699241
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64537958
57	Morphine addiction_Homo sapiens_hsa05032	0.63538830
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.62348483
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61896949
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.61420630
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.57125611
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.56891516
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.55792385
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54816132
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54044501
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.53946498
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52015010
68	Insulin secretion_Homo sapiens_hsa04911	0.50943399
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50128536
70	Fatty acid degradation_Homo sapiens_hsa00071	0.49340244
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46649225
72	GABAergic synapse_Homo sapiens_hsa04727	0.46262046
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45907384
74	DNA replication_Homo sapiens_hsa03030	0.45637405
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.44131841
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42678502
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38914343
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35024318
79	Serotonergic synapse_Homo sapiens_hsa04726	0.33561625
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.33502967
81	Axon guidance_Homo sapiens_hsa04360	0.33433760
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31932601
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30279698
84	Olfactory transduction_Homo sapiens_hsa04740	0.30053327
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29014113
86	Purine metabolism_Homo sapiens_hsa00230	0.27779446
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27137374
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23228698
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23081402
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22318540
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22058727
92	Spliceosome_Homo sapiens_hsa03040	0.21924921
93	Long-term depression_Homo sapiens_hsa04730	0.21198265
94	Taste transduction_Homo sapiens_hsa04742	0.21062902
95	Retinol metabolism_Homo sapiens_hsa00830	0.18099813
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.17202371
97	Circadian entrainment_Homo sapiens_hsa04713	0.16116809
98	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.15949594
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.15908583
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.15459029

RPS15P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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