RPS16P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.43535185
2pyrimidine-containing compound transmembrane transport (GO:0072531)4.66029972
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58215156
4negative regulation of cell killing (GO:0031342)4.58215156
5protein K11-linked deubiquitination (GO:0035871)4.55762323
6T cell migration (GO:0072678)4.45070947
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.20693924
8regulation of MHC class I biosynthetic process (GO:0045343)4.12846399
9hepatocyte apoptotic process (GO:0097284)4.03853251
10regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.01593892
11positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.01593892
12negative regulation of T cell mediated immunity (GO:0002710)3.99853040
13face development (GO:0060324)3.93653523
14regulation of gamma-delta T cell differentiation (GO:0045586)3.88464107
15establishment of protein localization to Golgi (GO:0072600)3.88013209
16protein targeting to Golgi (GO:0000042)3.75029593
17natural killer cell activation involved in immune response (GO:0002323)3.74610684
18positive regulation of granulocyte differentiation (GO:0030854)3.72615151
19histone mRNA catabolic process (GO:0071044)3.64782643
20mast cell activation involved in immune response (GO:0002279)3.64676873
21mast cell degranulation (GO:0043303)3.64676873
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64314088
23peptidyl-lysine trimethylation (GO:0018023)3.51846957
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.48947778
25negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.44497330
26negative regulation of T-helper cell differentiation (GO:0045623)3.44497330
27positive regulation of gamma-delta T cell activation (GO:0046645)3.41326308
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.38968704
29regulation of gamma-delta T cell activation (GO:0046643)3.37592305
30regulation of interleukin-6 biosynthetic process (GO:0045408)3.36701182
31negative regulation of type 2 immune response (GO:0002829)3.34414403
32microglial cell activation (GO:0001774)3.28441805
33negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.27157938
34leukocyte tethering or rolling (GO:0050901)3.20462387
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20315081
36nucleotide transmembrane transport (GO:1901679)3.20092351
37histone H3-K36 demethylation (GO:0070544)3.19760291
38protein K48-linked deubiquitination (GO:0071108)3.19204130
39detection of molecule of bacterial origin (GO:0032490)3.15457871
40negative regulation of B cell proliferation (GO:0030889)3.12428408
41negative T cell selection (GO:0043383)3.10614712
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06647749
43negative thymic T cell selection (GO:0045060)3.05896408
44negative regulation of adaptive immune response (GO:0002820)3.04040504
45response to pheromone (GO:0019236)3.03699658
46centriole replication (GO:0007099)3.01498971
47mast cell activation (GO:0045576)3.00035276
48macroautophagy (GO:0016236)2.96619234
49cytoplasmic mRNA processing body assembly (GO:0033962)2.94439779
50alpha-beta T cell differentiation (GO:0046632)2.94132778
51negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.93992842
52regulation of pigment cell differentiation (GO:0050932)2.92683325
53CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.89066272
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87222046
55histone H3-K9 methylation (GO:0051567)2.86737238
56regulation of B cell proliferation (GO:0030888)2.86623301
57response to interleukin-15 (GO:0070672)2.85209394
58dosage compensation (GO:0007549)2.84388368
59histone H3-K9 modification (GO:0061647)2.84068437
60response to muramyl dipeptide (GO:0032495)2.83971944
61B cell receptor signaling pathway (GO:0050853)2.83622091
62cellular response to ethanol (GO:0071361)2.81899461
63monoubiquitinated protein deubiquitination (GO:0035520)2.81745005
64rRNA catabolic process (GO:0016075)2.80413568
65regulation of establishment of cell polarity (GO:2000114)2.79879607
66dopamine transport (GO:0015872)2.77273309
67response to peptidoglycan (GO:0032494)2.76448976
68cellular extravasation (GO:0045123)2.74723240
69cellular response to interleukin-15 (GO:0071350)2.73988548
70regulation of fibroblast apoptotic process (GO:2000269)2.71609372
71positive regulation of B cell proliferation (GO:0030890)2.70617018
72microtubule anchoring (GO:0034453)2.68099158
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.67653015
74L-fucose catabolic process (GO:0042355)2.64410538
75fucose catabolic process (GO:0019317)2.64410538
76L-fucose metabolic process (GO:0042354)2.64410538
77T-helper cell differentiation (GO:0042093)2.63387665
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.63387665
79myeloid cell activation involved in immune response (GO:0002275)2.63158890
80negative regulation of leukocyte mediated immunity (GO:0002704)2.61276368
81positive T cell selection (GO:0043368)2.60047227
82regulation of DNA endoreduplication (GO:0032875)2.59529844
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.58951364
84interkinetic nuclear migration (GO:0022027)2.58272540
853-UTR-mediated mRNA stabilization (GO:0070935)2.57423413
86regulation of interferon-beta production (GO:0032648)2.57119217
87alpha-beta T cell activation (GO:0046631)2.56859233
88protein K63-linked deubiquitination (GO:0070536)2.54951976
89B cell proliferation (GO:0042100)2.54483379
90positive regulation of B cell differentiation (GO:0045579)2.54396716
91histone-serine phosphorylation (GO:0035404)2.53953240
92T cell proliferation (GO:0042098)2.52263923
93histone H3-K4 trimethylation (GO:0080182)2.52045207
94regulation of protein homodimerization activity (GO:0043496)2.51503396
95negative regulation of interleukin-12 production (GO:0032695)2.50190480
96interferon-gamma production (GO:0032609)2.49366356
97centrosome duplication (GO:0051298)2.45588320
98cellular response to exogenous dsRNA (GO:0071360)2.44424323
99pericardium development (GO:0060039)2.44411884
100B cell differentiation (GO:0030183)2.43157150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90851754
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36712040
3GATA1_22025678_ChIP-Seq_K562_Human3.19295153
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.03892811
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.01771987
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.96408842
7SCL_19346495_ChIP-Seq_HPC-7_Human2.84991737
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.78267074
9RUNX_20019798_ChIP-Seq_JUKART_Human2.77005680
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57320718
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43000267
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35417902
13MYB_26560356_Chip-Seq_TH2_Human2.10053472
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08621664
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02321259
16TP53_16413492_ChIP-PET_HCT116_Human2.01513816
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88910422
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85334474
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82884584
20GBX2_23144817_ChIP-Seq_PC3_Human1.79735265
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75224293
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74075645
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74075645
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72719539
25VDR_24787735_ChIP-Seq_THP-1_Human1.71919074
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.69460583
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66300753
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65834350
29GATA3_27048872_Chip-Seq_THYMUS_Human1.65450883
30MYB_26560356_Chip-Seq_TH1_Human1.64256018
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62029166
32ER_23166858_ChIP-Seq_MCF-7_Human1.61045826
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55898599
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54086397
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.53620308
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50204025
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49984073
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49165643
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44775591
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41877232
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.40494799
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39534153
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.39466756
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37980516
45TAF15_26573619_Chip-Seq_HEK293_Human1.36585722
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34762591
47AHR_22903824_ChIP-Seq_MCF-7_Human1.34402787
48IGF1R_20145208_ChIP-Seq_DFB_Human1.32453564
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32145263
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.30137837
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.30108393
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.30060871
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.28949974
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28808143
55IRF1_19129219_ChIP-ChIP_H3396_Human1.27966223
56SMAD4_21799915_ChIP-Seq_A2780_Human1.24539923
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23791550
58GATA3_26560356_Chip-Seq_TH2_Human1.22705927
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21995000
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.21715172
61STAT3_23295773_ChIP-Seq_U87_Human1.20930486
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19725836
63P300_19829295_ChIP-Seq_ESCs_Human1.19088075
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18409495
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.17332800
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.17112553
67GATA2_19941826_ChIP-Seq_K562_Human1.14984227
68AR_21572438_ChIP-Seq_LNCaP_Human1.14957527
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14430984
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12394402
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.11868387
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11739891
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10958923
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10384927
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09199352
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06165514
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05323369
78P53_22387025_ChIP-Seq_ESCs_Mouse1.04988810
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.04841999
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04778167
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.04773372
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04317699
83GATA1_19941826_ChIP-Seq_K562_Human1.02576102
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02562666
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02477651
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.02465736
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01677108
88PU_27001747_Chip-Seq_BMDM_Mouse1.01611710
89TCF4_23295773_ChIP-Seq_U87_Human1.01432793
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00222712
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00208024
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.99643552
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99516746
94RXR_22108803_ChIP-Seq_LS180_Human0.97771641
95CMYC_18555785_Chip-Seq_ESCs_Mouse0.96547181
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.96482651
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95952263
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95250117
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.94166097
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92753294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.90993811
2MP0008057_abnormal_DNA_replication3.49700916
3MP0001835_abnormal_antigen_presentation3.01814292
4MP0003763_abnormal_thymus_physiology2.81703104
5MP0003787_abnormal_imprinting2.65603488
6MP0003724_increased_susceptibility_to2.58304629
7MP0003303_peritoneal_inflammation2.54011999
8MP0000685_abnormal_immune_system2.43805662
9MP0002009_preneoplasia2.19981159
10MP0001800_abnormal_humoral_immune2.19732119
11MP0003656_abnormal_erythrocyte_physiolo2.13328170
12MP0002166_altered_tumor_susceptibility2.06761687
13MP0002876_abnormal_thyroid_physiology2.03688109
14MP0003183_abnormal_peptide_metabolism2.00956603
15MP0004381_abnormal_hair_follicle1.97090799
16MP0003890_abnormal_embryonic-extraembry1.94569949
17MP0004134_abnormal_chest_morphology1.92129671
18MP0002398_abnormal_bone_marrow1.90016522
19MP0003950_abnormal_plasma_membrane1.89025360
20MP0006082_CNS_inflammation1.86805735
21MP0002723_abnormal_immune_serum1.86705159
22MP0003828_pulmonary_edema1.83822554
23MP0002420_abnormal_adaptive_immunity1.78433043
24MP0005310_abnormal_salivary_gland1.75483635
25MP0001819_abnormal_immune_cell1.73407802
26MP0004808_abnormal_hematopoietic_stem1.68440611
27MP0002419_abnormal_innate_immunity1.68027069
28MP0005000_abnormal_immune_tolerance1.67753002
29MP0002332_abnormal_exercise_endurance1.67105642
30MP0002452_abnormal_antigen_presenting1.64730730
31MP0000716_abnormal_immune_system1.64220740
32MP0002396_abnormal_hematopoietic_system1.58500244
33MP0005174_abnormal_tail_pigmentation1.57641600
34MP0008877_abnormal_DNA_methylation1.56524530
35MP0005075_abnormal_melanosome_morpholog1.56261303
36MP0005464_abnormal_platelet_physiology1.53815642
37MP0004147_increased_porphyrin_level1.52326236
38MP0001873_stomach_inflammation1.52126775
39MP0003690_abnormal_glial_cell1.49654770
40MP0005387_immune_system_phenotype1.45432850
41MP0001790_abnormal_immune_system1.45432850
42MP0000689_abnormal_spleen_morphology1.44949347
43MP0002722_abnormal_immune_system1.43608952
44MP0004883_abnormal_blood_vessel1.42700454
45MP0003195_calcinosis1.42027235
46MP0000703_abnormal_thymus_morphology1.40420791
47MP0002006_tumorigenesis1.35974072
48MP0002148_abnormal_hypersensitivity_rea1.35444587
49MP0002405_respiratory_system_inflammati1.35415889
50MP0006054_spinal_hemorrhage1.30476297
51MP0000015_abnormal_ear_pigmentation1.29684122
52MP0002163_abnormal_gland_morphology1.24236674
53MP0002429_abnormal_blood_cell1.23624846
54MP0004484_altered_response_of1.22288094
55MP0001851_eye_inflammation1.20805573
56MP0009764_decreased_sensitivity_to1.19725342
57MP0001545_abnormal_hematopoietic_system1.16869558
58MP0005397_hematopoietic_system_phenotyp1.16869558
59MP0005025_abnormal_response_to1.11778009
60MP0003866_abnormal_defecation1.10979732
61MP0000427_abnormal_hair_cycle1.10582275
62MP0002998_abnormal_bone_remodeling1.08582932
63MP0003646_muscle_fatigue1.07817409
64MP0005076_abnormal_cell_differentiation1.06646174
65MP0003091_abnormal_cell_migration1.05514329
66MP0005671_abnormal_response_to1.04929189
67MP0004142_abnormal_muscle_tone1.04510979
68MP0004947_skin_inflammation1.04163050
69MP0005164_abnormal_response_to1.04140708
70MP0000372_irregular_coat_pigmentation1.01944066
71MP0000465_gastrointestinal_hemorrhage1.00997902
72MP0000371_diluted_coat_color1.00961318
73MP0001853_heart_inflammation0.95984137
74MP0003300_gastrointestinal_ulcer0.92047379
75MP0003436_decreased_susceptibility_to0.88877113
76MP0009250_abnormal_appendicular_skeleto0.88213794
77MP0001845_abnormal_inflammatory_respons0.86499504
78MP0003045_fibrosis0.82389871
79MP0002019_abnormal_tumor_incidence0.81576795
80MP0001346_abnormal_lacrimal_gland0.79865016
81MP0002933_joint_inflammation0.79775539
82MP0005167_abnormal_blood-brain_barrier0.78473620
83MP0010155_abnormal_intestine_physiology0.77953769
84MP0004130_abnormal_muscle_cell0.76646490
85MP0001663_abnormal_digestive_system0.75804552
86MP0009278_abnormal_bone_marrow0.73800421
87MP0005379_endocrine/exocrine_gland_phen0.71922634
88MP0008961_abnormal_basal_metabolism0.70921106
89MP0000249_abnormal_blood_vessel0.70058085
90MP0004264_abnormal_extraembryonic_tissu0.68322327
91MP0009785_altered_susceptibility_to0.67231664
92MP0003795_abnormal_bone_structure0.66587385
93MP0002160_abnormal_reproductive_system0.66323885
94MP0005220_abnormal_exocrine_pancreas0.66251485
95MP0005376_homeostasis/metabolism_phenot0.65922928
96MP0002136_abnormal_kidney_physiology0.65462401
97MP0005266_abnormal_metabolism0.62258218
98MP0000428_abnormal_craniofacial_morphol0.61262685
99MP0008873_increased_physiological_sensi0.61255028
100MP0005389_reproductive_system_phenotype0.60031634

Predicted human phenotypes

RankGene SetZ-score
1Abnormal tarsal ossification (HP:0008369)5.34356597
2Abnormal foot bone ossification (HP:0010675)4.86148238
3Hypoplastic scapulae (HP:0000882)4.40129118
4Aplasia/Hypoplasia of the scapulae (HP:0006713)4.40129118
5Flat acetabular roof (HP:0003180)4.29586355
6Abnormality of T cell number (HP:0011839)3.99017490
7T lymphocytopenia (HP:0005403)3.93767267
8Chronic mucocutaneous candidiasis (HP:0002728)3.73707945
9Recurrent cutaneous fungal infections (HP:0011370)3.73707945
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.69816526
11Spondylolisthesis (HP:0003302)3.36827412
12Genetic anticipation (HP:0003743)3.09648911
13Slow saccadic eye movements (HP:0000514)3.06742976
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.98479997
15Abnormality of the phalanges of the 2nd finger (HP:0009541)2.92896129
16Short middle phalanx of the 5th finger (HP:0004220)2.92796513
17Abnormality of carpal bone ossification (HP:0006257)2.85680289
18Abnormal hand bone ossification (HP:0010660)2.81492347
19Recurrent fungal infections (HP:0002841)2.71913671
20Hypoplastic iliac wings (HP:0002866)2.71344220
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63492232
22Abnormality of T cells (HP:0002843)2.63369317
23Spontaneous hematomas (HP:0007420)2.61292209
24Neoplasm of the tracheobronchial system (HP:0100552)2.61218809
25Cupped ribs (HP:0000887)2.61046907
26Absent frontal sinuses (HP:0002688)2.58734462
27Stomach cancer (HP:0012126)2.57165651
28Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56312908
29Recurrent bacterial skin infections (HP:0005406)2.55747924
30Thickened calvaria (HP:0002684)2.45520247
31Narrow palate (HP:0000189)2.44174924
32Alveolar cell carcinoma (HP:0006519)2.42339636
33Hypoplasia of the pons (HP:0012110)2.40007446
34Recurrent skin infections (HP:0001581)2.37475807
35Viral hepatitis (HP:0006562)2.36452813
36Tented upper lip vermilion (HP:0010804)2.35930044
37Panhypogammaglobulinemia (HP:0003139)2.34028106
38Abnormality of the pons (HP:0007361)2.33378329
39Absent speech (HP:0001344)2.30823817
40Increased density of long bones (HP:0006392)2.30529382
41Chromsome breakage (HP:0040012)2.29395649
42Optic neuritis (HP:0100653)2.29348290
43Retrobulbar optic neuritis (HP:0100654)2.29348290
44Persistence of primary teeth (HP:0006335)2.27358385
45Conjunctival telangiectasia (HP:0000524)2.25461595
46Spinal cord lesions (HP:0100561)2.24374675
47Syringomyelia (HP:0003396)2.24374675
48Abnormal ossification of hand bones (HP:0005921)2.23843485
49Impulsivity (HP:0100710)2.22594783
50Thyroiditis (HP:0100646)2.21716253
51Abnormality of the 2nd finger (HP:0004100)2.21681683
52Type II lissencephaly (HP:0007260)2.19796473
53Tapered finger (HP:0001182)2.16262960
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14513807
55Autoimmune thrombocytopenia (HP:0001973)2.14345268
56Truncal obesity (HP:0001956)2.13778157
57Volvulus (HP:0002580)2.11412424
58Neurodegeneration (HP:0002180)2.10665826
59Thoracolumbar scoliosis (HP:0002944)2.10532422
60Cerebellar dysplasia (HP:0007033)2.09822912
61Progressive cerebellar ataxia (HP:0002073)2.08877626
62Abnormality of the frontal sinuses (HP:0002687)2.08778772
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07724774
64Gingival bleeding (HP:0000225)2.07554494
65Mediastinal lymphadenopathy (HP:0100721)2.04649664
66Hip dysplasia (HP:0001385)2.03958666
67Recurrent bronchitis (HP:0002837)2.03931036
68Abnormality of T cell physiology (HP:0011840)2.01606954
69Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.00716064
70Subacute progressive viral hepatitis (HP:0006572)2.00677256
71Orchitis (HP:0100796)2.00476490
72Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.00073887
73IgG deficiency (HP:0004315)2.00037010
74Abnormality of the parietal bone (HP:0002696)1.99131735
75Autoimmune hemolytic anemia (HP:0001890)1.98535314
76Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.97607771
77Short ribs (HP:0000773)1.96232024
78Short 5th finger (HP:0009237)1.95744717
79Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93854600
80Arterial thrombosis (HP:0004420)1.92348586
81Neonatal respiratory distress (HP:0002643)1.92200687
82Febrile seizures (HP:0002373)1.91689842
83Gastrointestinal infarctions (HP:0005244)1.90185815
84Neonatal hypoglycemia (HP:0001998)1.89126544
85Aqueductal stenosis (HP:0002410)1.89110544
86Abnormality of eosinophils (HP:0001879)1.87704256
87Acute myeloid leukemia (HP:0004808)1.87442629
88Embryonal renal neoplasm (HP:0011794)1.87089447
89Abnormality of the prostate (HP:0008775)1.86464253
90Abnormality of the epiphyses of the hand (HP:0005924)1.85849442
91Abnormality of the wing of the ilium (HP:0011867)1.85015502
92Abnormality of the fingertips (HP:0001211)1.84951753
93Recurrent viral infections (HP:0004429)1.84692105
94Supernumerary bones of the axial skeleton (HP:0009144)1.84620880
95Encephalitis (HP:0002383)1.84088698
96Large earlobe (HP:0009748)1.82425891
97Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.82369640
98Submucous cleft hard palate (HP:0000176)1.82274836
99Microcytic anemia (HP:0001935)1.81779718
100Nephroblastoma (Wilms tumor) (HP:0002667)1.81265742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.23905155
2ACVR1B3.00068486
3AKT32.71514197
4BMPR22.57554408
5STK38L2.50537728
6IRAK12.41704448
7CDK122.31712970
8MAP4K12.24133468
9TAOK32.12213984
10IKBKE2.07222416
11BTK1.97499876
12IRAK21.92648652
13BMPR1B1.86860452
14PIK3CG1.82515670
15IRAK41.71793435
16BLK1.70592051
17MAP2K31.70462131
18WEE11.66007821
19TEC1.65324504
20WNK11.63454331
21TXK1.62546322
22MAP3K61.59280172
23GRK61.53012749
24BRSK21.50605156
25CAMK1D1.44986187
26TNIK1.42864419
27SYK1.42668319
28IKBKB1.36208475
29MAP4K21.34587795
30MAP3K141.34388099
31RIPK41.33269982
32TRPM71.30850448
33MAP3K21.29210306
34FES1.24783180
35PIK3CA1.24147504
36TGFBR21.23218448
37GRK51.21221925
38FGR1.20035896
39NLK1.09689552
40PIM11.05191602
41FGFR31.04783366
42CAMK1G1.04033586
43MELK1.02624758
44WNK41.01361669
45STK380.97288723
46PDK10.94435830
47STK390.92746555
48TNK20.91726848
49STK240.90372033
50BCR0.90270839
51SRPK10.89715585
52MAP3K70.88964227
53ADRBK10.87227113
54CDK90.86032110
55CAMKK20.85154908
56HCK0.84834346
57PNCK0.84236160
58CSF1R0.80609241
59CHUK0.79453385
60JAK30.77497974
61SGK20.75750796
62ITK0.75486846
63PTK2B0.75100020
64MATK0.74378122
65JAK10.73034357
66MARK30.73023032
67MAP3K10.71428333
68MAPKAPK20.69027099
69JAK20.66503972
70LRRK20.66235946
71LYN0.62453492
72DYRK30.62105786
73CSK0.61823850
74STK40.61457278
75ZAP700.61103176
76LCK0.59481988
77STK100.58949938
78TGFBR10.58671366
79LATS10.58101604
80NEK60.58071400
81RET0.55820214
82ERBB20.54365204
83BRD40.53960777
84CAMK40.52508261
85PRPF4B0.50726178
86MAP3K110.50584013
87PRKAA20.50527507
88STK110.49852086
89MAP2K40.49793812
90GRK70.49544284
91DYRK1A0.48449269
92SGK10.46572957
93PAK30.46121143
94CCNB10.45393861
95PRKAA10.43308546
96TBK10.43054911
97PRKCQ0.41927187
98PKN20.41823233
99RPS6KB20.41257820
100GRK10.40879488

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.30176156
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.12935727
3B cell receptor signaling pathway_Homo sapiens_hsa046622.09602777
4Osteoclast differentiation_Homo sapiens_hsa043801.95263590
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93667126
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91351453
7Acute myeloid leukemia_Homo sapiens_hsa052211.89308069
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86465152
9Leishmaniasis_Homo sapiens_hsa051401.84554159
10Non-small cell lung cancer_Homo sapiens_hsa052231.76197741
11Measles_Homo sapiens_hsa051621.71696098
12Dorso-ventral axis formation_Homo sapiens_hsa043201.70213142
13Hepatitis B_Homo sapiens_hsa051611.66934921
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.66351706
15TNF signaling pathway_Homo sapiens_hsa046681.62857888
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62231580
17T cell receptor signaling pathway_Homo sapiens_hsa046601.61991627
18Primary immunodeficiency_Homo sapiens_hsa053401.52705609
19FoxO signaling pathway_Homo sapiens_hsa040681.46776270
20Fatty acid biosynthesis_Homo sapiens_hsa000611.46292565
21Prostate cancer_Homo sapiens_hsa052151.43494170
22Hematopoietic cell lineage_Homo sapiens_hsa046401.43374173
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34064369
24Pancreatic cancer_Homo sapiens_hsa052121.33853913
25Circadian rhythm_Homo sapiens_hsa047101.32236370
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27939142
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26717966
28Fanconi anemia pathway_Homo sapiens_hsa034601.25834132
29Prolactin signaling pathway_Homo sapiens_hsa049171.24219004
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24125677
31Platelet activation_Homo sapiens_hsa046111.23643966
32Hepatitis C_Homo sapiens_hsa051601.16135170
33Influenza A_Homo sapiens_hsa051641.14699809
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13847979
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13590723
36Chronic myeloid leukemia_Homo sapiens_hsa052201.13029156
37Lysine degradation_Homo sapiens_hsa003101.12791212
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.11547445
39Inositol phosphate metabolism_Homo sapiens_hsa005621.11166680
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10702511
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10539777
42Endometrial cancer_Homo sapiens_hsa052131.10031394
43Systemic lupus erythematosus_Homo sapiens_hsa053221.09099762
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08813392
45Insulin resistance_Homo sapiens_hsa049311.07773384
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.07510739
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06910960
48Colorectal cancer_Homo sapiens_hsa052101.05920364
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.05713136
50Tuberculosis_Homo sapiens_hsa051521.02766849
51Olfactory transduction_Homo sapiens_hsa047401.01518300
52Small cell lung cancer_Homo sapiens_hsa052220.93746302
53Choline metabolism in cancer_Homo sapiens_hsa052310.88291785
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85291042
55Herpes simplex infection_Homo sapiens_hsa051680.84258012
56Viral carcinogenesis_Homo sapiens_hsa052030.83474141
57Malaria_Homo sapiens_hsa051440.82584251
58Nitrogen metabolism_Homo sapiens_hsa009100.82491166
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82393106
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82140842
61Toxoplasmosis_Homo sapiens_hsa051450.79888979
62ErbB signaling pathway_Homo sapiens_hsa040120.78992732
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78680789
64mTOR signaling pathway_Homo sapiens_hsa041500.78235977
65Glycerolipid metabolism_Homo sapiens_hsa005610.76448333
66Chemokine signaling pathway_Homo sapiens_hsa040620.72400027
67Type II diabetes mellitus_Homo sapiens_hsa049300.71524509
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70833146
69Apoptosis_Homo sapiens_hsa042100.70633037
70Graft-versus-host disease_Homo sapiens_hsa053320.69503576
71MicroRNAs in cancer_Homo sapiens_hsa052060.69460383
72Cholinergic synapse_Homo sapiens_hsa047250.68569998
73MAPK signaling pathway_Homo sapiens_hsa040100.68050651
74Glioma_Homo sapiens_hsa052140.67828888
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.67526668
76Ether lipid metabolism_Homo sapiens_hsa005650.67462729
77Renal cell carcinoma_Homo sapiens_hsa052110.66008943
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64885264
79Alcoholism_Homo sapiens_hsa050340.58553752
80Taste transduction_Homo sapiens_hsa047420.58518287
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58106441
82Histidine metabolism_Homo sapiens_hsa003400.54516666
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53383006
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.51509968
85cAMP signaling pathway_Homo sapiens_hsa040240.50578029
86Thyroid cancer_Homo sapiens_hsa052160.50572900
87Homologous recombination_Homo sapiens_hsa034400.50556601
88HTLV-I infection_Homo sapiens_hsa051660.49925967
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49616456
90Legionellosis_Homo sapiens_hsa051340.49132252
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49010292
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49008289
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.48054453
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.47032717
95Staphylococcus aureus infection_Homo sapiens_hsa051500.46457781
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46009634
97TGF-beta signaling pathway_Homo sapiens_hsa043500.45964596
98Melanoma_Homo sapiens_hsa052180.44968565
99Other glycan degradation_Homo sapiens_hsa005110.42099250
100Estrogen signaling pathway_Homo sapiens_hsa049150.41906907

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