RPS16P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)9.69811205
2positive regulation of inflammatory response to antigenic stimulus (GO:0002863)8.85597700
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)8.77547159
4regulation of hypersensitivity (GO:0002883)7.95335382
5ribosomal small subunit assembly (GO:0000028)7.26341523
6positive regulation of mast cell degranulation (GO:0043306)6.75588890
7positive regulation of mast cell activation involved in immune response (GO:0033008)6.75588890
8behavioral response to nicotine (GO:0035095)6.40680482
9viral transcription (GO:0019083)6.36730528
10maturation of SSU-rRNA (GO:0030490)6.25351527
11translational termination (GO:0006415)6.14045419
12regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.94860107
13protein neddylation (GO:0045116)5.49289955
14positive regulation of mast cell activation (GO:0033005)5.49140518
15ribosomal small subunit biogenesis (GO:0042274)5.21940655
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18368587
17cotranslational protein targeting to membrane (GO:0006613)5.14476903
18protein targeting to ER (GO:0045047)5.07050552
19translational elongation (GO:0006414)5.03658717
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.84078203
21positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.83748384
22cellular protein complex disassembly (GO:0043624)4.81831343
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.69048101
24viral life cycle (GO:0019058)4.68040286
25protein localization to endoplasmic reticulum (GO:0070972)4.67462269
26regulation of inflammatory response to antigenic stimulus (GO:0002861)4.50555019
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41472699
28ATP synthesis coupled proton transport (GO:0015986)4.41472699
29positive regulation of leukocyte degranulation (GO:0043302)4.15380396
30chaperone-mediated protein transport (GO:0072321)4.11529499
31regulation of chronic inflammatory response (GO:0002676)4.09702061
32protein complex disassembly (GO:0043241)4.00592904
33translational initiation (GO:0006413)3.96688115
34macromolecular complex disassembly (GO:0032984)3.87418341
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.80914062
36synaptic transmission, cholinergic (GO:0007271)3.62227485
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58681688
38ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.52838141
39microtubule severing (GO:0051013)3.37741316
40prepulse inhibition (GO:0060134)3.35972076
41positive regulation of B cell mediated immunity (GO:0002714)3.35232348
42positive regulation of immunoglobulin mediated immune response (GO:0002891)3.35232348
43protein targeting to membrane (GO:0006612)3.34821637
44monoamine transport (GO:0015844)3.34177199
45positive regulation of regulated secretory pathway (GO:1903307)3.32291757
46viral protein processing (GO:0019082)3.31916395
47endoderm formation (GO:0001706)3.27675298
48cell proliferation in forebrain (GO:0021846)3.26483647
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.26047416
50respiratory electron transport chain (GO:0022904)3.21903333
51axonal fasciculation (GO:0007413)3.17253077
52positive regulation of protein homooligomerization (GO:0032464)3.12716721
53electron transport chain (GO:0022900)3.12651946
54mRNA catabolic process (GO:0006402)3.10029443
55translation (GO:0006412)3.08771514
56sleep (GO:0030431)3.03608565
57mitochondrion morphogenesis (GO:0070584)3.03596043
58ribosomal large subunit biogenesis (GO:0042273)3.02181801
59negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.01515104
60piRNA metabolic process (GO:0034587)2.97993230
61short-term memory (GO:0007614)2.86116140
62rRNA catabolic process (GO:0016075)2.83449069
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79528527
64GTP biosynthetic process (GO:0006183)2.79421009
65cellular response to ATP (GO:0071318)2.78228851
66positive regulation of protein depolymerization (GO:1901881)2.77325811
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73716990
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73459646
69synaptic transmission, glutamatergic (GO:0035249)2.73239685
70RNA catabolic process (GO:0006401)2.72039761
71neuromuscular synaptic transmission (GO:0007274)2.71868147
72neuron recognition (GO:0008038)2.71193598
73T-helper 1 type immune response (GO:0042088)2.70316758
74nucleotide transmembrane transport (GO:1901679)2.70221025
75positive regulation of calcium-mediated signaling (GO:0050850)2.68957010
76positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.67430567
77olfactory bulb development (GO:0021772)2.67205008
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66006604
79positive regulation of respiratory burst (GO:0060267)2.65977768
80positive regulation of mitochondrial fission (GO:0090141)2.61014838
81leukotriene biosynthetic process (GO:0019370)2.60999872
82regulation of mast cell degranulation (GO:0043304)2.60936468
83protein-cofactor linkage (GO:0018065)2.58622960
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58155031
85dendritic spine morphogenesis (GO:0060997)2.56078185
86gamma-aminobutyric acid transport (GO:0015812)2.54293063
87regulation of mast cell activation involved in immune response (GO:0033006)2.52622845
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.52480630
89ATP biosynthetic process (GO:0006754)2.51439459
90negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50441712
91negative regulation of cAMP-mediated signaling (GO:0043951)2.49971638
92meiotic cell cycle (GO:0051321)2.47908009
93proton transport (GO:0015992)2.46332056
94positive regulation of interleukin-17 production (GO:0032740)2.44758045
95hydrogen transport (GO:0006818)2.44338262
96inner mitochondrial membrane organization (GO:0007007)2.44216521
97somite development (GO:0061053)2.43584556
98cardiovascular system development (GO:0072358)2.43406424
99thyroid hormone generation (GO:0006590)2.42532450
100positive regulation of activated T cell proliferation (GO:0042104)2.38978843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79685643
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21571105
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06570027
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92037106
5IGF1R_20145208_ChIP-Seq_DFB_Human2.82191887
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54606117
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53266729
8VDR_22108803_ChIP-Seq_LS180_Human2.47482366
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.47063130
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32704292
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15585997
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08262497
13REST_21632747_ChIP-Seq_MESCs_Mouse2.02328777
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.01633118
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.00492825
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94894053
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91245800
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84063735
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.83935450
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.74804403
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73958102
22ZNF274_21170338_ChIP-Seq_K562_Hela1.68306499
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66561744
24NANOG_20526341_ChIP-Seq_ESCs_Human1.64183036
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.63481807
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57464108
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56742628
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.56044655
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55274128
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55012936
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52801262
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51824134
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51314111
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.48391708
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45520626
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44146285
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.42946404
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37721376
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36785350
40MYC_19829295_ChIP-Seq_ESCs_Human1.36313242
41P300_19829295_ChIP-Seq_ESCs_Human1.34886010
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30870057
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.26613023
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25529749
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25391654
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25081952
47RNF2_27304074_Chip-Seq_NSC_Mouse1.24711280
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24378712
49MYC_18940864_ChIP-ChIP_HL60_Human1.22259153
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21577531
51AR_20517297_ChIP-Seq_VCAP_Human1.21184606
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20065103
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19798368
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18580576
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16533031
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16275377
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15611858
58ERA_21632823_ChIP-Seq_H3396_Human1.15173716
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14580010
60HTT_18923047_ChIP-ChIP_STHdh_Human1.13647093
61TTF2_22483619_ChIP-Seq_HELA_Human1.13636155
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13236799
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11123887
64OCT4_20526341_ChIP-Seq_ESCs_Human1.09087170
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07699429
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07663873
67TP53_22573176_ChIP-Seq_HFKS_Human1.07521282
68NANOG_19829295_ChIP-Seq_ESCs_Human1.06956123
69SOX2_19829295_ChIP-Seq_ESCs_Human1.06956123
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06904206
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04286864
72P53_21459846_ChIP-Seq_SAOS-2_Human1.03872979
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03385489
74FUS_26573619_Chip-Seq_HEK293_Human1.03374774
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02059326
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.01673999
77RAC3_21632823_ChIP-Seq_H3396_Human1.01016806
78FOXP3_21729870_ChIP-Seq_TREG_Human1.01016193
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00856554
80TAF2_19829295_ChIP-Seq_ESCs_Human0.99108739
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98475965
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98375963
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98275639
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97006831
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.96493142
86EWS_26573619_Chip-Seq_HEK293_Human0.94925276
87VDR_23849224_ChIP-Seq_CD4+_Human0.94211759
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.93616154
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.93039935
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92452032
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92237015
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92237015
93RNF2_27304074_Chip-Seq_ESCs_Mouse0.91107372
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90737813
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.90059045
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90059045
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.89849814
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89163999
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88479749
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86951145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.91444300
2MP0008877_abnormal_DNA_methylation3.81831445
3MP0004142_abnormal_muscle_tone3.24595384
4MP0006292_abnormal_olfactory_placode3.22873392
5MP0003787_abnormal_imprinting3.17021581
6MP0003122_maternal_imprinting2.83353459
7MP0003646_muscle_fatigue2.80360966
8MP0002876_abnormal_thyroid_physiology2.56995569
9MP0003121_genomic_imprinting2.40628447
10MP0001873_stomach_inflammation2.19553244
11MP0001986_abnormal_taste_sensitivity2.12005442
12MP0002638_abnormal_pupillary_reflex2.09727227
13MP0000778_abnormal_nervous_system2.09389803
14MP0002272_abnormal_nervous_system2.03551077
15MP0009764_decreased_sensitivity_to1.99269161
16MP0002102_abnormal_ear_morphology1.98227493
17MP0005360_urolithiasis1.86252258
18MP0009046_muscle_twitch1.85629304
19MP0002277_abnormal_respiratory_mucosa1.79330912
20MP0001485_abnormal_pinna_reflex1.76561234
21MP0003123_paternal_imprinting1.71403720
22MP0008872_abnormal_physiological_respon1.70903072
23MP0000427_abnormal_hair_cycle1.61672058
24MP0005423_abnormal_somatic_nervous1.61384076
25MP0006276_abnormal_autonomic_nervous1.61376452
26MP0004859_abnormal_synaptic_plasticity1.54588021
27MP0002837_dystrophic_cardiac_calcinosis1.54231129
28MP0000537_abnormal_urethra_morphology1.52683097
29MP0005167_abnormal_blood-brain_barrier1.52370075
30MP0006072_abnormal_retinal_apoptosis1.50613726
31MP0004742_abnormal_vestibular_system1.49374739
32MP0005499_abnormal_olfactory_system1.47246003
33MP0005394_taste/olfaction_phenotype1.47246003
34MP0001293_anophthalmia1.44615657
35MP0005551_abnormal_eye_electrophysiolog1.44255152
36MP0003136_yellow_coat_color1.42960051
37MP0010386_abnormal_urinary_bladder1.41652276
38MP0005377_hearing/vestibular/ear_phenot1.41132700
39MP0003878_abnormal_ear_physiology1.41132700
40MP0005645_abnormal_hypothalamus_physiol1.39874083
41MP0004145_abnormal_muscle_electrophysio1.38928635
42MP0008789_abnormal_olfactory_epithelium1.33796817
43MP0005389_reproductive_system_phenotype1.24870531
44MP0002184_abnormal_innervation1.23756875
45MP0005195_abnormal_posterior_eye1.23208222
46MP0000955_abnormal_spinal_cord1.22905911
47MP0001919_abnormal_reproductive_system1.19346927
48MP0003635_abnormal_synaptic_transmissio1.18825210
49MP0002734_abnormal_mechanical_nocicepti1.17604143
50MP0001188_hyperpigmentation1.17585974
51MP0002735_abnormal_chemical_nociception1.16289537
52MP0009745_abnormal_behavioral_response1.15321042
53MP0002572_abnormal_emotion/affect_behav1.13669005
54MP0001968_abnormal_touch/_nociception1.12938079
55MP0004270_analgesia1.12479906
56MP0001970_abnormal_pain_threshold1.12375745
57MP0002557_abnormal_social/conspecific_i1.11274461
58MP0002148_abnormal_hypersensitivity_rea1.06707549
59MP0000685_abnormal_immune_system1.06308226
60MP0005670_abnormal_white_adipose1.05469798
61MP0000631_abnormal_neuroendocrine_gland1.04715179
62MP0001984_abnormal_olfaction1.04421591
63MP0002653_abnormal_ependyma_morphology1.04139830
64MP0002752_abnormal_somatic_nervous1.03750423
65MP0003315_abnormal_perineum_morphology1.03301743
66MP0008775_abnormal_heart_ventricle0.99861165
67MP0001348_abnormal_lacrimal_gland0.99834346
68MP0005084_abnormal_gallbladder_morpholo0.99710318
69MP0005448_abnormal_energy_balance0.98369591
70MP0001663_abnormal_digestive_system0.97874205
71MP0004885_abnormal_endolymph0.97073646
72MP0001440_abnormal_grooming_behavior0.96752991
73MP0002160_abnormal_reproductive_system0.96417854
74MP0008875_abnormal_xenobiotic_pharmacok0.95391492
75MP0001501_abnormal_sleep_pattern0.95354365
76MP0000516_abnormal_urinary_system0.95183291
77MP0005367_renal/urinary_system_phenotyp0.95183291
78MP0002882_abnormal_neuron_morphology0.94808970
79MP0003880_abnormal_central_pattern0.93747271
80MP0000049_abnormal_middle_ear0.93635037
81MP0001324_abnormal_eye_pigmentation0.91973929
82MP0000465_gastrointestinal_hemorrhage0.91954209
83MP0002733_abnormal_thermal_nociception0.90612716
84MP0002063_abnormal_learning/memory/cond0.87147328
85MP0002095_abnormal_skin_pigmentation0.86912170
86MP0002067_abnormal_sensory_capabilities0.85995655
87MP0001502_abnormal_circadian_rhythm0.85487026
88MP0003195_calcinosis0.84220264
89MP0001963_abnormal_hearing_physiology0.83341455
90MP0001756_abnormal_urination0.82536173
91MP0001542_abnormal_bone_strength0.80178265
92MP0003942_abnormal_urinary_system0.80044967
93MP0005410_abnormal_fertilization0.78209271
94MP0001486_abnormal_startle_reflex0.76725082
95MP0004811_abnormal_neuron_physiology0.76720413
96MP0006035_abnormal_mitochondrial_morpho0.74954388
97MP0003690_abnormal_glial_cell0.72297010
98MP0002210_abnormal_sex_determination0.71175087
99MP0000026_abnormal_inner_ear0.70484833
100MP0001286_abnormal_eye_development0.70428392

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.99713488
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.34612285
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.34612285
4Abnormality of the corticospinal tract (HP:0002492)4.74234676
5Acute necrotizing encephalopathy (HP:0006965)4.70003547
6Myokymia (HP:0002411)4.45249391
7Septo-optic dysplasia (HP:0100842)4.31993346
8Abnormal mitochondria in muscle tissue (HP:0008316)4.20150929
9Abnormality of cells of the erythroid lineage (HP:0012130)4.12197027
10Genetic anticipation (HP:0003743)4.09113589
11Acute encephalopathy (HP:0006846)4.05059877
12Agitation (HP:0000713)3.85181271
13Progressive macrocephaly (HP:0004481)3.82319235
14Papilledema (HP:0001085)3.73498697
15Stenosis of the external auditory canal (HP:0000402)3.59255367
16Mitochondrial inheritance (HP:0001427)3.28920085
17Increased CSF lactate (HP:0002490)3.16494370
18Absent thumb (HP:0009777)3.13128101
19Macrocytic anemia (HP:0001972)2.89051828
20Absent septum pellucidum (HP:0001331)2.86383387
21Keratoconus (HP:0000563)2.85404791
22Increased corneal curvature (HP:0100692)2.85404791
23Restlessness (HP:0000711)2.85380793
24Impaired vibration sensation in the lower limbs (HP:0002166)2.82986800
25Urinary bladder sphincter dysfunction (HP:0002839)2.81068789
26Cerebral edema (HP:0002181)2.75670558
27Insidious onset (HP:0003587)2.73909238
28Termporal pattern (HP:0011008)2.73909238
29Polyphagia (HP:0002591)2.73369840
30Hepatocellular necrosis (HP:0001404)2.69594205
31Medial flaring of the eyebrow (HP:0010747)2.65791305
32Pallor (HP:0000980)2.64358454
33Enlarged penis (HP:0000040)2.64074533
34Abnormal hemoglobin (HP:0011902)2.62461722
35Humeroradial synostosis (HP:0003041)2.60049075
36Synostosis involving the elbow (HP:0003938)2.60049075
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56835733
38Anterior segment dysgenesis (HP:0007700)2.56728002
39Optic disc pallor (HP:0000543)2.50777260
40Decreased central vision (HP:0007663)2.50454104
41Abnormality of the labia minora (HP:0012880)2.45398965
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42136125
43Abnormality of alanine metabolism (HP:0010916)2.42136125
44Hyperalaninemia (HP:0003348)2.42136125
45Type II lissencephaly (HP:0007260)2.40436369
46Disinhibition (HP:0000734)2.28454036
47Abnormality of the septum pellucidum (HP:0007375)2.27803265
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26527226
49Horseshoe kidney (HP:0000085)2.26189379
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22990517
51Congenital, generalized hypertrichosis (HP:0004540)2.20729159
52Morphological abnormality of the pyramidal tract (HP:0002062)2.18500059
53Hyperglycinemia (HP:0002154)2.16921617
54Lissencephaly (HP:0001339)2.16765361
55Impulsivity (HP:0100710)2.16482408
56Abnormal number of erythroid precursors (HP:0012131)2.15823640
57Pendular nystagmus (HP:0012043)2.15082668
58Adrenal hypoplasia (HP:0000835)2.11307287
59Hepatic necrosis (HP:0002605)2.11101575
60Growth hormone deficiency (HP:0000824)2.06424952
61Optic nerve hypoplasia (HP:0000609)2.01360789
62Hyperthyroidism (HP:0000836)1.96892563
63Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96331063
64Failure to thrive in infancy (HP:0001531)1.96012911
65Abnormality of reticulocytes (HP:0004312)1.91765758
66Hypoplasia of the radius (HP:0002984)1.90650202
67Maternal diabetes (HP:0009800)1.87079396
68Thyroid-stimulating hormone excess (HP:0002925)1.85737806
69Small hand (HP:0200055)1.84230198
70Abnormal rod and cone electroretinograms (HP:0008323)1.83413339
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83306282
72Diastasis recti (HP:0001540)1.82111997
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80265868
74Myotonia (HP:0002486)1.79241844
75Leukodystrophy (HP:0002415)1.78660981
76Abnormality of the nasal septum (HP:0000419)1.77503725
77Confusion (HP:0001289)1.75837673
78Pancreatic cysts (HP:0001737)1.75730717
79Abnormality of the phalanges of the 5th finger (HP:0004213)1.75521860
80Fetal akinesia sequence (HP:0001989)1.74859664
81CNS demyelination (HP:0007305)1.74568489
82Chronic hepatic failure (HP:0100626)1.74293973
83Increased hepatocellular lipid droplets (HP:0006565)1.73947784
84Chorioretinal atrophy (HP:0000533)1.72915884
85Increased serum lactate (HP:0002151)1.72595932
86Submucous cleft hard palate (HP:0000176)1.71297974
87Hypoplasia of the ulna (HP:0003022)1.70760313
88Inappropriate behavior (HP:0000719)1.70296499
89Respiratory failure (HP:0002878)1.70288307
90Severe muscular hypotonia (HP:0006829)1.70117447
91Colon cancer (HP:0003003)1.69733701
92Esotropia (HP:0000565)1.69583234
93Forearm undergrowth (HP:0009821)1.69294169
94Hyperphosphatemia (HP:0002905)1.69017107
95Protruding tongue (HP:0010808)1.68747981
96Cerebellar dysplasia (HP:0007033)1.68648695
97Methylmalonic aciduria (HP:0012120)1.68589122
98Lipid accumulation in hepatocytes (HP:0006561)1.68443522
99Supernumerary ribs (HP:0005815)1.66569701
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66183446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.44368493
2EPHB23.53282566
3MAP3K113.15549042
4CDK193.04565195
5SRPK12.86105896
6WNK42.82665654
7MARK32.41747474
8PIK3CA2.28204395
9NME12.21294782
10TAOK32.16465188
11MARK12.06450805
12STK391.88682428
13PINK11.87341363
14MAP2K71.79427741
15DYRK21.76621865
16FRK1.72386342
17OXSR11.66796669
18MAP4K21.62996315
19CSNK1G21.60466492
20NTRK21.59353243
21TLK11.59205099
22MAP3K91.58739001
23CASK1.55549586
24PRKCG1.54043519
25TNIK1.43294870
26GRK11.33916181
27MAP3K41.32292093
28KSR11.31857342
29ARAF1.31113566
30TRIM281.24850106
31MAP4K11.15849194
32CAMKK11.13797852
33DYRK1B1.13765261
34MINK11.12944085
35SIK21.07405589
36PRKCQ1.06788167
37MAPK131.05654905
38CAMKK21.03231075
39PRKCZ0.98225127
40PHKG20.97561824
41PHKG10.97561824
42TNK20.95884965
43ICK0.94504642
44ADRBK20.85886581
45MAP3K20.84040482
46LRRK20.83638573
47PRKCH0.83574981
48INSRR0.82177511
49PRKCI0.80059770
50WNK30.77365247
51CDK30.73256541
52PAK30.72841126
53CSNK1G30.72522667
54EIF2AK20.72040338
55MAP3K60.70464370
56MAP2K40.69837427
57PRKCD0.69517002
58BRAF0.69360322
59TEC0.68529296
60PIM20.67647361
61NUAK10.66517792
62BCR0.63387806
63PRKCE0.62178064
64WNK10.61504863
65CSNK2A20.61355426
66CSNK1A1L0.61317457
67CAMK10.60474377
68PRKACA0.56524356
69NEK10.53508830
70RPS6KA50.53418368
71PDK20.52658456
72MAPK150.52642009
73SIK10.52490448
74OBSCN0.52180048
75CSNK1E0.50768386
76AURKA0.50586633
77PRKG10.48157242
78RPS6KA60.47816880
79ADRBK10.47666203
80LIMK10.47535931
81DAPK30.47418965
82CSNK1G10.45603016
83CDK140.44559121
84PIK3CG0.44283883
85DYRK1A0.43586099
86STK110.42510606
87GRK70.42023017
88MAPKAPK30.41809140
89BMX0.41752464
90ERBB20.40074536
91IKBKB0.38199647
92CSNK2A10.37747566
93CAMK2A0.37072737
94PRKAA10.35010638
95CSNK1A10.34844008
96NEK20.34657132
97PRKCA0.34454106
98CDK11A0.33607921
99CSNK1D0.32876476
100IRAK40.30968361

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.72950628
2Asthma_Homo sapiens_hsa053105.03692104
3Oxidative phosphorylation_Homo sapiens_hsa001903.75261390
4Parkinsons disease_Homo sapiens_hsa050123.31587153
5Nicotine addiction_Homo sapiens_hsa050332.97384052
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47997987
7Alzheimers disease_Homo sapiens_hsa050102.32097082
8Huntingtons disease_Homo sapiens_hsa050162.29324357
9Phototransduction_Homo sapiens_hsa047442.25575836
10Cardiac muscle contraction_Homo sapiens_hsa042602.16749803
11Sulfur relay system_Homo sapiens_hsa041222.09085090
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06374439
13Proteasome_Homo sapiens_hsa030501.99038383
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87608319
15RNA polymerase_Homo sapiens_hsa030201.83663521
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65293897
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.60045388
18Protein export_Homo sapiens_hsa030601.59870934
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59831059
20Dorso-ventral axis formation_Homo sapiens_hsa043201.54318026
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52504350
22RNA degradation_Homo sapiens_hsa030181.47095800
23Morphine addiction_Homo sapiens_hsa050321.38071702
24Butanoate metabolism_Homo sapiens_hsa006501.32080940
25Type I diabetes mellitus_Homo sapiens_hsa049401.29666684
26Basal transcription factors_Homo sapiens_hsa030221.23334450
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14387834
28Autoimmune thyroid disease_Homo sapiens_hsa053201.07920234
29Insulin secretion_Homo sapiens_hsa049111.05669977
30Allograft rejection_Homo sapiens_hsa053301.03101716
31Cocaine addiction_Homo sapiens_hsa050301.02529313
32Vitamin B6 metabolism_Homo sapiens_hsa007501.02267109
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02107795
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.97068664
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96938039
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89986255
37Fat digestion and absorption_Homo sapiens_hsa049750.88440150
38Rheumatoid arthritis_Homo sapiens_hsa053230.87623444
39Peroxisome_Homo sapiens_hsa041460.84536777
40Glycerolipid metabolism_Homo sapiens_hsa005610.82217453
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82058455
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81236058
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80211148
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79238655
45Chemical carcinogenesis_Homo sapiens_hsa052040.79007600
46Nitrogen metabolism_Homo sapiens_hsa009100.76926578
47Tryptophan metabolism_Homo sapiens_hsa003800.76045909
48Salivary secretion_Homo sapiens_hsa049700.75794150
49Caffeine metabolism_Homo sapiens_hsa002320.73314985
50Synaptic vesicle cycle_Homo sapiens_hsa047210.73240275
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72009701
52African trypanosomiasis_Homo sapiens_hsa051430.70573286
53Collecting duct acid secretion_Homo sapiens_hsa049660.70045070
54GABAergic synapse_Homo sapiens_hsa047270.69987649
55Linoleic acid metabolism_Homo sapiens_hsa005910.69341522
56Retinol metabolism_Homo sapiens_hsa008300.69154973
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68356744
58Graft-versus-host disease_Homo sapiens_hsa053320.66796704
59Starch and sucrose metabolism_Homo sapiens_hsa005000.64843351
60Olfactory transduction_Homo sapiens_hsa047400.64004888
61Fanconi anemia pathway_Homo sapiens_hsa034600.63684273
62Glutamatergic synapse_Homo sapiens_hsa047240.62401749
63Hematopoietic cell lineage_Homo sapiens_hsa046400.62235580
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.61167302
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56287826
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54094491
67Homologous recombination_Homo sapiens_hsa034400.53120828
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52030449
69Axon guidance_Homo sapiens_hsa043600.50643186
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50317944
71Histidine metabolism_Homo sapiens_hsa003400.48710054
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45698354
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45642194
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45167203
75beta-Alanine metabolism_Homo sapiens_hsa004100.44964850
76Mineral absorption_Homo sapiens_hsa049780.43552092
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41791151
78Systemic lupus erythematosus_Homo sapiens_hsa053220.41662581
79Propanoate metabolism_Homo sapiens_hsa006400.40911348
80Selenocompound metabolism_Homo sapiens_hsa004500.40670167
81Metabolic pathways_Homo sapiens_hsa011000.39004429
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.38940920
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.38918131
84Amphetamine addiction_Homo sapiens_hsa050310.38319458
85Ovarian steroidogenesis_Homo sapiens_hsa049130.37734993
86Sphingolipid metabolism_Homo sapiens_hsa006000.37515209
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.35162971
88Sulfur metabolism_Homo sapiens_hsa009200.35152427
89Purine metabolism_Homo sapiens_hsa002300.33397477
90Taste transduction_Homo sapiens_hsa047420.32994740
91cAMP signaling pathway_Homo sapiens_hsa040240.32121047
92Cholinergic synapse_Homo sapiens_hsa047250.31500674
93Arginine and proline metabolism_Homo sapiens_hsa003300.30422611
94Alcoholism_Homo sapiens_hsa050340.30303364
95Dopaminergic synapse_Homo sapiens_hsa047280.29299127
96Vitamin digestion and absorption_Homo sapiens_hsa049770.26874825
97Pyrimidine metabolism_Homo sapiens_hsa002400.26704948
98Bile secretion_Homo sapiens_hsa049760.26488445
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25584722
100Circadian entrainment_Homo sapiens_hsa047130.21512147

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