RPS16P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.15171538
2translational termination (GO:0006415)7.79658035
3ribosomal small subunit assembly (GO:0000028)7.67885430
4maturation of SSU-rRNA (GO:0030490)7.40366073
5ribosomal small subunit biogenesis (GO:0042274)7.24358103
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.65641317
7cotranslational protein targeting to membrane (GO:0006613)6.53253560
8protein targeting to ER (GO:0045047)6.50611641
9translational elongation (GO:0006414)6.48025938
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.25026800
11protein localization to endoplasmic reticulum (GO:0070972)6.14682713
12cellular protein complex disassembly (GO:0043624)5.86658415
13viral life cycle (GO:0019058)5.83918522
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.61676339
15ATP synthesis coupled proton transport (GO:0015986)5.51056410
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51056410
17translational initiation (GO:0006413)5.08554828
18protein complex disassembly (GO:0043241)5.03400268
19protein neddylation (GO:0045116)4.98137913
20macromolecular complex disassembly (GO:0032984)4.80023536
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.78515991
22ribosomal large subunit biogenesis (GO:0042273)4.72216750
23protein targeting to membrane (GO:0006612)4.39177739
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34576529
25behavioral response to nicotine (GO:0035095)4.26574323
26translation (GO:0006412)4.06286831
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.02937484
28substrate-independent telencephalic tangential migration (GO:0021826)4.02937484
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.00355006
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.00355006
31NADH dehydrogenase complex assembly (GO:0010257)4.00355006
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.93189402
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.88099918
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.88099918
35respiratory electron transport chain (GO:0022904)3.81981845
36electron transport chain (GO:0022900)3.80485078
37protein complex biogenesis (GO:0070271)3.79882507
38chaperone-mediated protein transport (GO:0072321)3.78390645
39mRNA catabolic process (GO:0006402)3.73063339
40DNA deamination (GO:0045006)3.60632198
41ribonucleoprotein complex biogenesis (GO:0022613)3.50702382
42cell proliferation in forebrain (GO:0021846)3.50524230
43cellular component biogenesis (GO:0044085)3.49250785
44RNA catabolic process (GO:0006401)3.31795497
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31490345
46ATP biosynthetic process (GO:0006754)3.28093083
47preassembly of GPI anchor in ER membrane (GO:0016254)3.27642681
48mitochondrial respiratory chain complex assembly (GO:0033108)3.23060297
49kynurenine metabolic process (GO:0070189)3.19511363
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16156493
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.14617735
52tongue development (GO:0043586)3.12335148
53somite development (GO:0061053)3.11429574
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10129003
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03398805
56water-soluble vitamin biosynthetic process (GO:0042364)3.02671353
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97345869
58establishment of protein localization to membrane (GO:0090150)2.95459710
59hydrogen ion transmembrane transport (GO:1902600)2.91472536
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90298188
61neuron fate determination (GO:0048664)2.88127633
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.87813068
63positive regulation of T cell apoptotic process (GO:0070234)2.84076863
64parturition (GO:0007567)2.82851822
65protein targeting (GO:0006605)2.79929039
66cardiovascular system development (GO:0072358)2.78972306
67GTP biosynthetic process (GO:0006183)2.78357292
68nonmotile primary cilium assembly (GO:0035058)2.77642029
69ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76754546
70hypothalamus development (GO:0021854)2.75590819
71regulation of cellular respiration (GO:0043457)2.74312433
72platelet dense granule organization (GO:0060155)2.70803035
73protein-cofactor linkage (GO:0018065)2.70699875
74aldehyde catabolic process (GO:0046185)2.68983825
75motile cilium assembly (GO:0044458)2.67136061
76negative regulation of telomere maintenance (GO:0032205)2.66447966
77protein polyglutamylation (GO:0018095)2.65388858
78tryptophan catabolic process (GO:0006569)2.65306658
79indole-containing compound catabolic process (GO:0042436)2.65306658
80indolalkylamine catabolic process (GO:0046218)2.65306658
81peptidyl-histidine modification (GO:0018202)2.64965664
82GPI anchor metabolic process (GO:0006505)2.64746075
83spinal cord association neuron differentiation (GO:0021527)2.64549173
84proton transport (GO:0015992)2.63976209
85rRNA processing (GO:0006364)2.62308701
86pyrimidine nucleotide catabolic process (GO:0006244)2.61447790
87establishment of protein localization to organelle (GO:0072594)2.59732571
88epithelial cilium movement (GO:0003351)2.59167645
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59163962
90hydrogen transport (GO:0006818)2.57387228
91rRNA metabolic process (GO:0016072)2.57350775
92regulation of cilium movement (GO:0003352)2.55357246
93GPI anchor biosynthetic process (GO:0006506)2.52218532
94indolalkylamine metabolic process (GO:0006586)2.51015001
95cellular biogenic amine catabolic process (GO:0042402)2.50577694
96amine catabolic process (GO:0009310)2.50577694
97iron coordination entity transport (GO:1901678)2.47924932
98ncRNA 3-end processing (GO:0043628)2.47757498
99positive regulation of respiratory burst (GO:0060267)2.47579789
100telencephalon development (GO:0021537)2.44955399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89856225
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48686993
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.62014150
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.56049933
5VDR_22108803_ChIP-Seq_LS180_Human3.19263530
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.71048866
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56818332
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.53960948
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38598033
10IRF1_19129219_ChIP-ChIP_H3396_Human2.31025303
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21645763
12ZNF274_21170338_ChIP-Seq_K562_Hela2.12833445
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08752804
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.08393077
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93653639
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92091087
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.84474387
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.78516713
19VDR_23849224_ChIP-Seq_CD4+_Human1.76646827
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76567586
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67225641
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64848685
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60836428
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.58752713
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58592652
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.57571338
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57506852
28MYC_18940864_ChIP-ChIP_HL60_Human1.50827988
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47395575
30TTF2_22483619_ChIP-Seq_HELA_Human1.47279892
31FOXP3_21729870_ChIP-Seq_TREG_Human1.46518357
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.45350252
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43282103
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42151714
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.38791405
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38205064
37TP53_22573176_ChIP-Seq_HFKS_Human1.35119255
38ELK1_19687146_ChIP-ChIP_HELA_Human1.34426317
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33347872
40REST_21632747_ChIP-Seq_MESCs_Mouse1.32489233
41GABP_19822575_ChIP-Seq_HepG2_Human1.31121500
42XRN2_22483619_ChIP-Seq_HELA_Human1.30335272
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30116911
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29998196
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.29650522
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.29505072
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28537454
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28000199
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26635917
50ERA_21632823_ChIP-Seq_H3396_Human1.26150073
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25716641
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25519560
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.25504135
54TAF2_19829295_ChIP-Seq_ESCs_Human1.25462687
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23696244
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23510485
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23406586
58NANOG_20526341_ChIP-Seq_ESCs_Human1.23233207
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21860126
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21332418
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.18214926
62IGF1R_20145208_ChIP-Seq_DFB_Human1.18178733
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.17196025
64NCOR_22424771_ChIP-Seq_293T_Human1.16672494
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12310194
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11900646
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11259035
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11252443
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10933553
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09557034
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08829016
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.07746759
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07665986
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06765848
75P53_21459846_ChIP-Seq_SAOS-2_Human1.05354840
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04923453
77MYC_19829295_ChIP-Seq_ESCs_Human1.04241968
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.04052883
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99183301
80AR_20517297_ChIP-Seq_VCAP_Human0.98615776
81RNF2_27304074_Chip-Seq_NSC_Mouse0.98307912
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97133882
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96851102
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96770879
85EWS_26573619_Chip-Seq_HEK293_Human0.95211433
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93728974
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.93598909
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93047672
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.92190017
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92190017
91FUS_26573619_Chip-Seq_HEK293_Human0.91828951
92CTCF_20526341_ChIP-Seq_ESCs_Human0.89646796
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88450010
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88295151
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.87798730
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87708684
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87700457
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87642820
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.86189963
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.85893658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.89662392
2MP0006292_abnormal_olfactory_placode5.43562177
3MP0003787_abnormal_imprinting3.02423876
4MP0003122_maternal_imprinting2.76683904
5MP0004142_abnormal_muscle_tone2.60955035
6MP0008789_abnormal_olfactory_epithelium2.47078555
7MP0002653_abnormal_ependyma_morphology2.42836470
8MP0002163_abnormal_gland_morphology2.41203013
9MP0003646_muscle_fatigue2.38504504
10MP0004885_abnormal_endolymph2.23048216
11MP0008877_abnormal_DNA_methylation2.16706983
12MP0004147_increased_porphyrin_level2.13273418
13MP0005646_abnormal_pituitary_gland2.10408178
14MP0001986_abnormal_taste_sensitivity2.01783856
15MP0002102_abnormal_ear_morphology2.01279527
16MP0005377_hearing/vestibular/ear_phenot1.99961721
17MP0003878_abnormal_ear_physiology1.99961721
18MP0005394_taste/olfaction_phenotype1.96306296
19MP0005499_abnormal_olfactory_system1.96306296
20MP0003121_genomic_imprinting1.95289534
21MP0006276_abnormal_autonomic_nervous1.78304537
22MP0005671_abnormal_response_to1.70425132
23MP0002837_dystrophic_cardiac_calcinosis1.68585842
24MP0001968_abnormal_touch/_nociception1.64503294
25MP0001293_anophthalmia1.64270961
26MP0005423_abnormal_somatic_nervous1.61256846
27MP0002095_abnormal_skin_pigmentation1.56230577
28MP0003123_paternal_imprinting1.52282172
29MP0004145_abnormal_muscle_electrophysio1.50671632
30MP0005551_abnormal_eye_electrophysiolog1.49220753
31MP0000631_abnormal_neuroendocrine_gland1.45700025
32MP0000778_abnormal_nervous_system1.44925420
33MP0000049_abnormal_middle_ear1.41784046
34MP0001188_hyperpigmentation1.39332801
35MP0003880_abnormal_central_pattern1.39271755
36MP0008872_abnormal_physiological_respon1.38257512
37MP0002733_abnormal_thermal_nociception1.38148448
38MP0003136_yellow_coat_color1.36559654
39MP0008875_abnormal_xenobiotic_pharmacok1.35417387
40MP0002272_abnormal_nervous_system1.34556991
41MP0006072_abnormal_retinal_apoptosis1.33222052
42MP0010030_abnormal_orbit_morphology1.26907869
43MP0005379_endocrine/exocrine_gland_phen1.25232220
44MP0000372_irregular_coat_pigmentation1.25046788
45MP0001485_abnormal_pinna_reflex1.22883336
46MP0002736_abnormal_nociception_after1.21657913
47MP0001905_abnormal_dopamine_level1.20975436
48MP0001529_abnormal_vocalization1.20544386
49MP0002138_abnormal_hepatobiliary_system1.20131588
50MP0002938_white_spotting1.19094043
51MP0001970_abnormal_pain_threshold1.17962994
52MP0002876_abnormal_thyroid_physiology1.17542032
53MP0005645_abnormal_hypothalamus_physiol1.17297055
54MP0005195_abnormal_posterior_eye1.11859316
55MP0003186_abnormal_redox_activity1.11259724
56MP0009745_abnormal_behavioral_response1.11162877
57MP0005084_abnormal_gallbladder_morpholo1.10027890
58MP0002234_abnormal_pharynx_morphology1.09839091
59MP0000026_abnormal_inner_ear1.08846438
60MP0008775_abnormal_heart_ventricle1.05853093
61MP0002638_abnormal_pupillary_reflex1.05822588
62MP0002277_abnormal_respiratory_mucosa1.03332334
63MP0001486_abnormal_startle_reflex1.02427264
64MP0002557_abnormal_social/conspecific_i1.00145215
65MP0001440_abnormal_grooming_behavior0.97999996
66MP0002184_abnormal_innervation0.96183119
67MP0002752_abnormal_somatic_nervous0.93755535
68MP0003938_abnormal_ear_development0.93386511
69MP0000427_abnormal_hair_cycle0.93335863
70MP0003879_abnormal_hair_cell0.91499418
71MP0001286_abnormal_eye_development0.90558778
72MP0001963_abnormal_hearing_physiology0.90542773
73MP0004742_abnormal_vestibular_system0.89648614
74MP0001984_abnormal_olfaction0.87633995
75MP0003011_delayed_dark_adaptation0.87142538
76MP0002734_abnormal_mechanical_nocicepti0.87073068
77MP0004043_abnormal_pH_regulation0.86993640
78MP0002822_catalepsy0.84939009
79MP0002160_abnormal_reproductive_system0.82471206
80MP0000955_abnormal_spinal_cord0.81867283
81MP0005670_abnormal_white_adipose0.80035997
82MP0002572_abnormal_emotion/affect_behav0.80004916
83MP0005389_reproductive_system_phenotype0.79952726
84MP0005174_abnormal_tail_pigmentation0.79336233
85MP0002063_abnormal_learning/memory/cond0.78289898
86MP0009764_decreased_sensitivity_to0.75868346
87MP0002210_abnormal_sex_determination0.74310001
88MP0002067_abnormal_sensory_capabilities0.70090012
89MP0001502_abnormal_circadian_rhythm0.69418746
90MP0001919_abnormal_reproductive_system0.68702216
91MP0003635_abnormal_synaptic_transmissio0.68646311
92MP0009046_muscle_twitch0.68454040
93MP0000230_abnormal_systemic_arterial0.65891914
94MP0001324_abnormal_eye_pigmentation0.62528930
95MP0004133_heterotaxia0.62378437
96MP0005332_abnormal_amino_acid0.61451693
97MP0005253_abnormal_eye_physiology0.59109186
98MP0002233_abnormal_nose_morphology0.58702661
99MP0005075_abnormal_melanosome_morpholog0.58136398
100MP0001119_abnormal_female_reproductive0.56938952

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.74922764
2Abnormality of cells of the erythroid lineage (HP:0012130)4.85627773
3Acute necrotizing encephalopathy (HP:0006965)4.51384990
4Abnormal mitochondria in muscle tissue (HP:0008316)3.99238406
5Acute encephalopathy (HP:0006846)3.85452443
6Macrocytic anemia (HP:0001972)3.77912145
7Mitochondrial inheritance (HP:0001427)3.70126987
8Abnormal number of erythroid precursors (HP:0012131)3.67780196
9Progressive macrocephaly (HP:0004481)3.56356621
10Septo-optic dysplasia (HP:0100842)3.53213401
11Pallor (HP:0000980)3.50273265
12Molar tooth sign on MRI (HP:0002419)3.49417761
13Abnormality of midbrain morphology (HP:0002418)3.49417761
14Pancreatic fibrosis (HP:0100732)3.45861394
15Medial flaring of the eyebrow (HP:0010747)3.31046632
16Stenosis of the external auditory canal (HP:0000402)3.26370167
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21332671
18Pancreatic cysts (HP:0001737)3.20721478
19Increased CSF lactate (HP:0002490)3.18313175
20Nephronophthisis (HP:0000090)3.11139051
21True hermaphroditism (HP:0010459)3.08009835
22Abnormal rod and cone electroretinograms (HP:0008323)2.80619608
23Absent thumb (HP:0009777)2.74860350
24Abnormality of alanine metabolism (HP:0010916)2.73757624
25Hyperalaninemia (HP:0003348)2.73757624
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73757624
27Nephrogenic diabetes insipidus (HP:0009806)2.72529401
28Sclerocornea (HP:0000647)2.69829469
29Cerebral edema (HP:0002181)2.68816980
30Pendular nystagmus (HP:0012043)2.68555544
31Gait imbalance (HP:0002141)2.68261752
32Hepatocellular necrosis (HP:0001404)2.66093507
33Congenital primary aphakia (HP:0007707)2.63809686
343-Methylglutaconic aciduria (HP:0003535)2.63570907
35Asplenia (HP:0001746)2.61398087
36Increased hepatocellular lipid droplets (HP:0006565)2.60707827
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59941926
38Type 2 muscle fiber atrophy (HP:0003554)2.59645835
39Adrenal hypoplasia (HP:0000835)2.57825091
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.56235914
41Lipid accumulation in hepatocytes (HP:0006561)2.56010782
42Abnormal hemoglobin (HP:0011902)2.56000071
43Abnormality of the renal medulla (HP:0100957)2.54819782
44Abnormality of the labia minora (HP:0012880)2.53924167
45Congenital stationary night blindness (HP:0007642)2.50321027
46Absent/shortened dynein arms (HP:0200106)2.48480619
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.48480619
48Absent septum pellucidum (HP:0001331)2.37799744
49Hepatic necrosis (HP:0002605)2.35138036
50Cystic liver disease (HP:0006706)2.34221689
51Optic disc pallor (HP:0000543)2.30157220
52Rib fusion (HP:0000902)2.29680527
53Abnormality of DNA repair (HP:0003254)2.27385450
54Colon cancer (HP:0003003)2.26862053
55Muscle fiber atrophy (HP:0100295)2.24202240
56Depressed nasal ridge (HP:0000457)2.24051450
57Increased intramyocellular lipid droplets (HP:0012240)2.18450477
58Myokymia (HP:0002411)2.18281032
59Methylmalonic acidemia (HP:0002912)2.16644711
60Abolished electroretinogram (ERG) (HP:0000550)2.15938251
61Anophthalmia (HP:0000528)2.15820224
62Tubular atrophy (HP:0000092)2.14107326
63Anencephaly (HP:0002323)2.11341803
64Renal Fanconi syndrome (HP:0001994)2.10349614
65Optic nerve hypoplasia (HP:0000609)2.06983953
66Leukodystrophy (HP:0002415)2.06947901
67Type II lissencephaly (HP:0007260)2.06883528
68Increased serum lactate (HP:0002151)2.05718489
69Maternal diabetes (HP:0009800)2.04255711
70Decreased central vision (HP:0007663)2.03378141
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02597284
72Oligomenorrhea (HP:0000876)2.01835524
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99819474
74Lactic acidosis (HP:0003128)1.98281431
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.97585103
76Vaginal atresia (HP:0000148)1.93999012
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93249191
78Poor coordination (HP:0002370)1.90891502
79Hyperglycinemia (HP:0002154)1.89963729
80Hypoplasia of the radius (HP:0002984)1.86559181
81Increased muscle lipid content (HP:0009058)1.85818946
82Genital tract atresia (HP:0001827)1.84483818
83Postaxial foot polydactyly (HP:0001830)1.84371585
84Exertional dyspnea (HP:0002875)1.83277123
85Chronic hepatic failure (HP:0100626)1.82109768
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80480230
87Keratoconus (HP:0000563)1.79246986
88Increased corneal curvature (HP:0100692)1.79246986
89Chronic bronchitis (HP:0004469)1.78168684
90Elevated erythrocyte sedimentation rate (HP:0003565)1.77721917
91Abnormality of the renal cortex (HP:0011035)1.76516831
92Growth hormone deficiency (HP:0000824)1.76002727
93Optic nerve coloboma (HP:0000588)1.74461699
94Abnormal drinking behavior (HP:0030082)1.72188868
95Polydipsia (HP:0001959)1.72188868
96Oligodactyly (hands) (HP:0001180)1.70662578
97Male pseudohermaphroditism (HP:0000037)1.68889838
98Cerebral hypomyelination (HP:0006808)1.68180905
99Abnormality of the renal collecting system (HP:0004742)1.68165232
100Exercise intolerance (HP:0003546)1.67881571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.04072294
2CDK192.98407633
3STK162.95988465
4ADRBK22.78540195
5TLK12.60866747
6GRK12.39177298
7TAOK32.38472453
8PIK3CA2.31898796
9NUAK12.31182983
10TXK2.16391295
11TIE12.11645638
12ZAK2.11546057
13DYRK22.11126657
14BCKDK1.93966594
15MAP3K111.80009375
16PINK11.74513176
17MAP4K21.67418154
18NTRK21.50508918
19TYRO31.49934626
20PRKD31.41115538
21MAP3K121.36252004
22AKT31.33020565
23PLK41.32192229
24WNK31.30287173
25MAPK131.28122634
26NME21.19562872
27INSRR1.17437070
28VRK21.17324975
29MAP2K71.11959590
30PRKCG1.09557707
31CAMK11.09353493
32NEK11.09286117
33STK391.08775746
34PASK1.08233965
35EPHB21.07957640
36KDR1.07679679
37BRAF1.05858888
38ADRBK11.03122212
39FRK1.02451674
40MAP4K10.98051649
41OXSR10.96017005
42PRKCH0.95336400
43CDC70.90822967
44TEC0.89610909
45ITK0.86500366
46BCR0.86407002
47IKBKB0.85262364
48NME10.84126907
49DAPK30.82664658
50OBSCN0.82097225
51VRK10.82036066
52LIMK10.80579463
53PRKCQ0.80460203
54DYRK1B0.79460894
55PHKG20.79230484
56PHKG10.79230484
57NTRK30.76392540
58PAK30.75297828
59MAP3K40.75175622
60PRKACA0.73580627
61MUSK0.73578688
62AURKA0.72549879
63LRRK20.72393345
64WNK10.72262209
65BTK0.70640039
66PRKCE0.69181270
67CAMKK20.66428726
68CDK80.66326386
69EPHA40.64786193
70CSNK1A10.64187283
71CSNK2A20.61929552
72TNK20.60488743
73AURKB0.60408648
74CAMKK10.59683545
75GRK70.59551163
76PDK20.59026514
77ABL20.57640554
78CASK0.56897032
79RPS6KA50.56854801
80STK110.56604337
81STK30.55417963
82ILK0.53829205
83CSNK1G20.53807673
84TRIM280.53032113
85CSNK1G30.51337216
86PRKCA0.48662547
87RPS6KA60.48453239
88SGK10.45575480
89PIM10.45235203
90MYLK0.45008455
91SGK2230.44243822
92SGK4940.44243822
93FES0.43604872
94PLK20.42760996
95PRKCI0.42238032
96CAMK2A0.41961103
97CSNK2A10.41889928
98LCK0.41600494
99TESK20.41483118
100PRKCD0.41072175

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.00150728
2Oxidative phosphorylation_Homo sapiens_hsa001904.38288505
3Parkinsons disease_Homo sapiens_hsa050123.67609735
4Cardiac muscle contraction_Homo sapiens_hsa042602.67880282
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66725780
6Alzheimers disease_Homo sapiens_hsa050102.54512695
7Huntingtons disease_Homo sapiens_hsa050162.50815069
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41677428
9Proteasome_Homo sapiens_hsa030502.15839398
10Protein export_Homo sapiens_hsa030602.13307096
11One carbon pool by folate_Homo sapiens_hsa006702.04786080
12Linoleic acid metabolism_Homo sapiens_hsa005911.88599439
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70490391
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65736577
15RNA polymerase_Homo sapiens_hsa030201.61568366
16Phototransduction_Homo sapiens_hsa047441.54503160
17Sulfur relay system_Homo sapiens_hsa041221.53991736
18Asthma_Homo sapiens_hsa053101.49561916
19RNA degradation_Homo sapiens_hsa030181.48212492
20Primary immunodeficiency_Homo sapiens_hsa053401.38242124
21Caffeine metabolism_Homo sapiens_hsa002321.29264729
22Homologous recombination_Homo sapiens_hsa034401.27040100
23Nicotine addiction_Homo sapiens_hsa050331.26742249
24Nitrogen metabolism_Homo sapiens_hsa009101.26016459
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19056345
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.18164722
27Basal transcription factors_Homo sapiens_hsa030221.16906252
28Fanconi anemia pathway_Homo sapiens_hsa034601.15237879
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13946705
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12658148
31Graft-versus-host disease_Homo sapiens_hsa053321.11905350
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10149020
33Mismatch repair_Homo sapiens_hsa034301.07438380
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05172140
35Allograft rejection_Homo sapiens_hsa053301.03618538
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03078039
37Autoimmune thyroid disease_Homo sapiens_hsa053200.96404219
38Nucleotide excision repair_Homo sapiens_hsa034200.96244072
39Morphine addiction_Homo sapiens_hsa050320.96056656
40Regulation of autophagy_Homo sapiens_hsa041400.95653992
41Ether lipid metabolism_Homo sapiens_hsa005650.93304594
42Arachidonic acid metabolism_Homo sapiens_hsa005900.92471705
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90857129
44Propanoate metabolism_Homo sapiens_hsa006400.90154609
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.87665328
46Type I diabetes mellitus_Homo sapiens_hsa049400.83137274
47Hedgehog signaling pathway_Homo sapiens_hsa043400.82950913
48Tryptophan metabolism_Homo sapiens_hsa003800.78707614
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78544395
50Pyrimidine metabolism_Homo sapiens_hsa002400.76876413
51Peroxisome_Homo sapiens_hsa041460.73970365
52Purine metabolism_Homo sapiens_hsa002300.72346806
53Butanoate metabolism_Homo sapiens_hsa006500.70772365
54Chemical carcinogenesis_Homo sapiens_hsa052040.69639651
55Fat digestion and absorption_Homo sapiens_hsa049750.68336835
56RNA transport_Homo sapiens_hsa030130.67751622
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67408437
58Olfactory transduction_Homo sapiens_hsa047400.67238518
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66969391
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66069376
61Metabolic pathways_Homo sapiens_hsa011000.65150795
62Folate biosynthesis_Homo sapiens_hsa007900.65013836
63Spliceosome_Homo sapiens_hsa030400.62792729
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61408595
65Basal cell carcinoma_Homo sapiens_hsa052170.60543028
66DNA replication_Homo sapiens_hsa030300.60010564
67GABAergic synapse_Homo sapiens_hsa047270.59367214
68Fatty acid elongation_Homo sapiens_hsa000620.55838713
69Antigen processing and presentation_Homo sapiens_hsa046120.55677227
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55068997
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.55037814
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52651516
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51755753
74Selenocompound metabolism_Homo sapiens_hsa004500.47214864
75Glutathione metabolism_Homo sapiens_hsa004800.46321358
76Pyruvate metabolism_Homo sapiens_hsa006200.44559908
77Rheumatoid arthritis_Homo sapiens_hsa053230.43414005
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42855179
79Retinol metabolism_Homo sapiens_hsa008300.41753829
80Serotonergic synapse_Homo sapiens_hsa047260.41219223
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37075441
82Steroid biosynthesis_Homo sapiens_hsa001000.36106641
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.35447070
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34870451
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34643119
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34636616
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.34557812
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34333962
89Insulin secretion_Homo sapiens_hsa049110.34057930
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.34044982
91Taste transduction_Homo sapiens_hsa047420.33915633
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33411667
93Collecting duct acid secretion_Homo sapiens_hsa049660.31168192
94beta-Alanine metabolism_Homo sapiens_hsa004100.27815044
95Glutamatergic synapse_Homo sapiens_hsa047240.23399258
96Ovarian steroidogenesis_Homo sapiens_hsa049130.23262531
97Base excision repair_Homo sapiens_hsa034100.21452203
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20726674
99Arginine and proline metabolism_Homo sapiens_hsa003300.17912036
100Fatty acid degradation_Homo sapiens_hsa000710.17297416

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