RPS17P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.97267097
2viral transcription (GO:0019083)7.31817182
3ribosomal small subunit biogenesis (GO:0042274)7.03813232
4translational termination (GO:0006415)7.00881786
5DNA deamination (GO:0045006)6.55660487
6translational elongation (GO:0006414)6.27087513
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.01193832
8cotranslational protein targeting to membrane (GO:0006613)5.91380236
9protein targeting to ER (GO:0045047)5.87273349
10maturation of SSU-rRNA (GO:0030490)5.65562926
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.61519308
12protein localization to endoplasmic reticulum (GO:0070972)5.53121707
13chaperone-mediated protein transport (GO:0072321)5.50083955
14energy coupled proton transport, down electrochemical gradient (GO:0015985)5.37212129
15ATP synthesis coupled proton transport (GO:0015986)5.37212129
16cellular protein complex disassembly (GO:0043624)5.31715654
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30621804
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.26523720
19viral life cycle (GO:0019058)5.23899178
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.09270798
21cytidine deamination (GO:0009972)5.05592214
22cytidine metabolic process (GO:0046087)5.05592214
23cytidine catabolic process (GO:0006216)5.05592214
24translational initiation (GO:0006413)4.83387423
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.48479578
26translation (GO:0006412)4.44872028
27pyrimidine ribonucleoside catabolic process (GO:0046133)4.40704543
28protein complex disassembly (GO:0043241)4.39429197
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36523921
30respiratory electron transport chain (GO:0022904)4.16322302
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.15461493
32macromolecular complex disassembly (GO:0032984)4.14290524
33protein neddylation (GO:0045116)4.12904674
34electron transport chain (GO:0022900)4.07122801
35protein targeting to membrane (GO:0006612)3.99911663
36protein complex biogenesis (GO:0070271)3.92938798
37response to gravity (GO:0009629)3.77480422
38ribosomal large subunit biogenesis (GO:0042273)3.69370230
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.60958152
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60491902
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.60491902
42NADH dehydrogenase complex assembly (GO:0010257)3.60491902
43GTP biosynthetic process (GO:0006183)3.57797852
44mitochondrial respiratory chain complex assembly (GO:0033108)3.57547377
45pyrimidine nucleotide catabolic process (GO:0006244)3.53378604
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44328033
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44328033
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43568627
49ribonucleoprotein complex biogenesis (GO:0022613)3.39832967
50mRNA catabolic process (GO:0006402)3.39679838
51cellular component biogenesis (GO:0044085)3.34064341
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.29325015
53protein-cofactor linkage (GO:0018065)3.25437341
54protein deneddylation (GO:0000338)3.23722408
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21872886
56cullin deneddylation (GO:0010388)3.21193035
57ATP biosynthetic process (GO:0006754)3.20333593
58behavioral response to nicotine (GO:0035095)3.14412833
59UTP biosynthetic process (GO:0006228)3.13698649
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13239964
61intracellular protein transmembrane import (GO:0044743)3.11959877
62RNA catabolic process (GO:0006401)3.08178696
63negative regulation by host of viral transcription (GO:0043922)3.06684265
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.06081982
65termination of RNA polymerase III transcription (GO:0006386)3.06081982
66rRNA processing (GO:0006364)3.01817090
67rRNA metabolic process (GO:0016072)3.00267977
68negative regulation of muscle hypertrophy (GO:0014741)3.00123617
69metallo-sulfur cluster assembly (GO:0031163)2.98823531
70iron-sulfur cluster assembly (GO:0016226)2.98823531
71positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.91734999
72hydrogen ion transmembrane transport (GO:1902600)2.90993169
73gonadal mesoderm development (GO:0007506)2.86254579
74water-soluble vitamin biosynthetic process (GO:0042364)2.84847653
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83776997
76ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80851850
77ncRNA 3-end processing (GO:0043628)2.80630736
78spliceosomal complex assembly (GO:0000245)2.79497999
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79141621
80negative regulation of telomere maintenance (GO:0032205)2.79013695
81positive regulation of histone H3-K4 methylation (GO:0051571)2.78910455
82ubiquinone biosynthetic process (GO:0006744)2.72033962
83UTP metabolic process (GO:0046051)2.71878293
84positive regulation of natural killer cell mediated immunity (GO:0002717)2.70460074
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.69908829
86proton transport (GO:0015992)2.69452294
87protein targeting to mitochondrion (GO:0006626)2.68954414
88pseudouridine synthesis (GO:0001522)2.66996069
89protein targeting (GO:0006605)2.65705329
90establishment of protein localization to membrane (GO:0090150)2.64814522
91establishment of protein localization to mitochondrion (GO:0072655)2.62391201
92hydrogen transport (GO:0006818)2.61602318
93skeletal muscle tissue regeneration (GO:0043403)2.59772759
94regulation of skeletal muscle contraction (GO:0014819)2.57895721
95proteasome assembly (GO:0043248)2.57630203
96protein polyglutamylation (GO:0018095)2.56231382
97guanosine-containing compound biosynthetic process (GO:1901070)2.55574521
98GPI anchor metabolic process (GO:0006505)2.54321222
99GPI anchor biosynthetic process (GO:0006506)2.53888475
100cell proliferation in forebrain (GO:0021846)2.50893368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.95419339
2VDR_22108803_ChIP-Seq_LS180_Human4.16594493
3EZH2_22144423_ChIP-Seq_EOC_Human4.16140027
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.91447353
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18190064
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16752723
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.11361361
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.04100983
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73586974
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.67886920
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60768638
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53277556
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34346286
14VDR_23849224_ChIP-Seq_CD4+_Human2.23084970
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10824441
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.07425867
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00087198
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99816898
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.99598574
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98096110
21IGF1R_20145208_ChIP-Seq_DFB_Human1.80135589
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73503349
23TP53_22573176_ChIP-Seq_HFKS_Human1.71841974
24MYC_18940864_ChIP-ChIP_HL60_Human1.69584928
25FOXP3_21729870_ChIP-Seq_TREG_Human1.66801373
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66659133
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66581057
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64297595
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.61839080
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60133594
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48148613
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.46911702
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.46904915
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.45918213
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45221523
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44105697
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43329398
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43212723
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41289867
40ZNF274_21170338_ChIP-Seq_K562_Hela1.41224588
41TTF2_22483619_ChIP-Seq_HELA_Human1.37819396
42ELK1_19687146_ChIP-ChIP_HELA_Human1.37030522
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36543622
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.31812321
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.29197640
46XRN2_22483619_ChIP-Seq_HELA_Human1.26733692
47FUS_26573619_Chip-Seq_HEK293_Human1.26669692
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.26034490
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23241641
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22734560
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20526604
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19151909
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18680986
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17167499
55NANOG_20526341_ChIP-Seq_ESCs_Human1.17141307
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14554355
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13298360
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10046325
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09184055
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07825999
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06754023
62TAF2_19829295_ChIP-Seq_ESCs_Human1.02735069
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02626600
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02621496
65EWS_26573619_Chip-Seq_HEK293_Human0.99324566
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99045685
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97849395
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97421069
69JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97333849
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97107565
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96818167
72EZH2_27294783_Chip-Seq_ESCs_Mouse0.96738857
73ER_23166858_ChIP-Seq_MCF-7_Human0.96356853
74NCOR_22424771_ChIP-Seq_293T_Human0.95375468
75MYC_19829295_ChIP-Seq_ESCs_Human0.95174766
76BCL6_27268052_Chip-Seq_Bcells_Human0.93881703
77MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93671172
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.92504888
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91713793
80AR_20517297_ChIP-Seq_VCAP_Human0.91559046
81ERG_20517297_ChIP-Seq_VCAP_Human0.91530095
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91163079
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.89562821
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89345505
85TAF15_26573619_Chip-Seq_HEK293_Human0.87852784
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87244691
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.87244691
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87100273
89GABP_19822575_ChIP-Seq_HepG2_Human0.85776238
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85713638
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85379381
92DCP1A_22483619_ChIP-Seq_HELA_Human0.85231984
93RNF2_27304074_Chip-Seq_NSC_Mouse0.85221266
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84371838
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83943239
96SA1_27219007_Chip-Seq_Bcells_Human0.83780504
97IRF8_21731497_ChIP-ChIP_J774_Mouse0.83690239
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81334906
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80908362
100SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80799313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.02236647
2MP0006292_abnormal_olfactory_placode3.84162324
3MP0005671_abnormal_response_to3.54423051
4MP0004145_abnormal_muscle_electrophysio3.34361361
5MP0004147_increased_porphyrin_level2.50945524
6MP0002638_abnormal_pupillary_reflex2.47940534
7MP0003646_muscle_fatigue2.45869821
8MP0000049_abnormal_middle_ear2.40492763
9MP0002102_abnormal_ear_morphology2.22600385
10MP0002163_abnormal_gland_morphology2.14656386
11MP0002837_dystrophic_cardiac_calcinosis2.06570438
12MP0004142_abnormal_muscle_tone2.02070498
13MP0001485_abnormal_pinna_reflex2.00056246
14MP0008995_early_reproductive_senescence1.93116164
15MP0005645_abnormal_hypothalamus_physiol1.91419425
16MP0008789_abnormal_olfactory_epithelium1.86312848
17MP0002822_catalepsy1.81525003
18MP0008877_abnormal_DNA_methylation1.79814115
19MP0001968_abnormal_touch/_nociception1.75980315
20MP0002234_abnormal_pharynx_morphology1.73526873
21MP0002160_abnormal_reproductive_system1.73444770
22MP0000372_irregular_coat_pigmentation1.64866785
23MP0008872_abnormal_physiological_respon1.62154710
24MP0002277_abnormal_respiratory_mucosa1.60172852
25MP0001873_stomach_inflammation1.59579269
26MP0000678_abnormal_parathyroid_gland1.57214916
27MP0005389_reproductive_system_phenotype1.56128866
28MP0002736_abnormal_nociception_after1.53777835
29MP0003787_abnormal_imprinting1.50622581
30MP0009333_abnormal_splenocyte_physiolog1.50566688
31MP0006072_abnormal_retinal_apoptosis1.44260071
32MP0003938_abnormal_ear_development1.36668918
33MP0004885_abnormal_endolymph1.35607509
34MP0002653_abnormal_ependyma_morphology1.34012584
35MP0005551_abnormal_eye_electrophysiolog1.31136743
36MP0000685_abnormal_immune_system1.29846935
37MP0001905_abnormal_dopamine_level1.28609785
38MP0005377_hearing/vestibular/ear_phenot1.26361435
39MP0003878_abnormal_ear_physiology1.26361435
40MP0003136_yellow_coat_color1.25422334
41MP0005379_endocrine/exocrine_gland_phen1.24771604
42MP0002095_abnormal_skin_pigmentation1.24736560
43MP0002735_abnormal_chemical_nociception1.23608579
44MP0001919_abnormal_reproductive_system1.23272532
45MP0003806_abnormal_nucleotide_metabolis1.22980110
46MP0003786_premature_aging1.21177597
47MP0009785_altered_susceptibility_to1.20902481
48MP0003763_abnormal_thymus_physiology1.19759153
49MP0001529_abnormal_vocalization1.18071376
50MP0006276_abnormal_autonomic_nervous1.16607261
51MP0005646_abnormal_pituitary_gland1.14863409
52MP0003122_maternal_imprinting1.11891624
53MP0003880_abnormal_central_pattern1.11555482
54MP0002249_abnormal_larynx_morphology1.11548019
55MP0005394_taste/olfaction_phenotype1.11245765
56MP0005499_abnormal_olfactory_system1.11245765
57MP0008875_abnormal_xenobiotic_pharmacok1.10096228
58MP0001188_hyperpigmentation1.05994018
59MP0000631_abnormal_neuroendocrine_gland1.05968563
60MP0005084_abnormal_gallbladder_morpholo1.05857824
61MP0002138_abnormal_hepatobiliary_system1.05484929
62MP0003123_paternal_imprinting1.03641064
63MP0002733_abnormal_thermal_nociception1.01765653
64MP0002272_abnormal_nervous_system1.01150222
65MP0001348_abnormal_lacrimal_gland0.99908089
66MP0003121_genomic_imprinting0.98742285
67MP0009745_abnormal_behavioral_response0.97000990
68MP0001800_abnormal_humoral_immune0.95187962
69MP0001963_abnormal_hearing_physiology0.95169679
70MP0005075_abnormal_melanosome_morpholog0.94946109
71MP0009250_abnormal_appendicular_skeleto0.93598045
72MP0001790_abnormal_immune_system0.87932593
73MP0005387_immune_system_phenotype0.87932593
74MP0004742_abnormal_vestibular_system0.87175307
75MP0002184_abnormal_innervation0.85412672
76MP0001486_abnormal_startle_reflex0.84938406
77MP0009765_abnormal_xenobiotic_induced0.84217822
78MP0001970_abnormal_pain_threshold0.83721546
79MP0002723_abnormal_immune_serum0.82181845
80MP0002089_abnormal_postnatal_growth/wei0.80692553
81MP0000703_abnormal_thymus_morphology0.80656093
82MP0003567_abnormal_fetal_cardiomyocyte0.78486789
83MP0000026_abnormal_inner_ear0.76693533
84MP0002420_abnormal_adaptive_immunity0.76659334
85MP0002210_abnormal_sex_determination0.76633258
86MP0001835_abnormal_antigen_presentation0.76177030
87MP0001293_anophthalmia0.75072464
88MP0005636_abnormal_mineral_homeostasis0.74131733
89MP0001819_abnormal_immune_cell0.73628056
90MP0005000_abnormal_immune_tolerance0.73416497
91MP0005253_abnormal_eye_physiology0.71703361
92MP0004036_abnormal_muscle_relaxation0.70728693
93MP0001986_abnormal_taste_sensitivity0.70485586
94MP0002108_abnormal_muscle_morphology0.70334317
95MP0008961_abnormal_basal_metabolism0.70071513
96MP0001542_abnormal_bone_strength0.69400686
97MP0002106_abnormal_muscle_physiology0.69389794
98MP0002148_abnormal_hypersensitivity_rea0.69281915
99MP0002752_abnormal_somatic_nervous0.67540490
100MP0000613_abnormal_salivary_gland0.65983559

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.38897544
2Acute necrotizing encephalopathy (HP:0006965)5.08336738
3Abnormality of cells of the erythroid lineage (HP:0012130)4.68738662
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.63880993
5Mitochondrial inheritance (HP:0001427)4.61578697
6Abnormal mitochondria in muscle tissue (HP:0008316)4.48588453
7Acute encephalopathy (HP:0006846)4.20366276
8Progressive macrocephaly (HP:0004481)4.03684815
9Cerebral edema (HP:0002181)3.79183023
10Abnormal number of erythroid precursors (HP:0012131)3.78807570
11Increased CSF lactate (HP:0002490)3.78030358
12Increased hepatocellular lipid droplets (HP:0006565)3.72514591
13Hepatocellular necrosis (HP:0001404)3.70056849
14Abnormal rod and cone electroretinograms (HP:0008323)3.68981685
15Palpebral edema (HP:0100540)3.66829227
16Stenosis of the external auditory canal (HP:0000402)3.65636424
17Macrocytic anemia (HP:0001972)3.55821934
18Hepatic necrosis (HP:0002605)3.28177235
19Lipid accumulation in hepatocytes (HP:0006561)3.25745586
20Abnormality of the renal collecting system (HP:0004742)3.19372347
21IgG deficiency (HP:0004315)3.13796408
22Optic disc pallor (HP:0000543)3.09520992
23Increased intramyocellular lipid droplets (HP:0012240)3.08769899
243-Methylglutaconic aciduria (HP:0003535)3.06420169
25Congenital stationary night blindness (HP:0007642)3.06221021
26Renal Fanconi syndrome (HP:0001994)3.01401277
27Pallor (HP:0000980)3.00772027
28Increased IgM level (HP:0003496)2.95897846
29Absent thumb (HP:0009777)2.88964798
30Aplastic anemia (HP:0001915)2.79995367
31Severe combined immunodeficiency (HP:0004430)2.64094933
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60257233
33Increased serum lactate (HP:0002151)2.56731042
34Exertional dyspnea (HP:0002875)2.54293241
35Septo-optic dysplasia (HP:0100842)2.53745544
36Increased muscle lipid content (HP:0009058)2.50539056
37Pancreatic cysts (HP:0001737)2.50427873
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48645081
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48645081
40Lactic acidosis (HP:0003128)2.46238479
41Pancreatic fibrosis (HP:0100732)2.43792980
42Constricted visual fields (HP:0001133)2.41049750
43Abnormality of midbrain morphology (HP:0002418)2.39884501
44Molar tooth sign on MRI (HP:0002419)2.39884501
45Respiratory failure (HP:0002878)2.39378450
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36139620
47Exercise intolerance (HP:0003546)2.34168072
48Asplenia (HP:0001746)2.34055430
49Abolished electroretinogram (ERG) (HP:0000550)2.27680712
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.25440505
51Elevated erythrocyte sedimentation rate (HP:0003565)2.25130339
52Absent phalangeal crease (HP:0006109)2.23138485
53Lethargy (HP:0001254)2.21080255
54Pendular nystagmus (HP:0012043)2.17498429
55Abnormality of renal resorption (HP:0011038)2.11407987
56Abnormality of B cell number (HP:0010975)2.09647489
57Polydipsia (HP:0001959)2.03157375
58Abnormal drinking behavior (HP:0030082)2.03157375
59Leukodystrophy (HP:0002415)2.02502705
60Attenuation of retinal blood vessels (HP:0007843)1.99379580
61B lymphocytopenia (HP:0010976)1.98946855
62True hermaphroditism (HP:0010459)1.98279648
63Periorbital edema (HP:0100539)1.98108747
64Respiratory difficulties (HP:0002880)1.96626715
65Pancytopenia (HP:0001876)1.95928261
66Myotonia (HP:0002486)1.95133086
67Distal arthrogryposis (HP:0005684)1.92183833
68Combined immunodeficiency (HP:0005387)1.92130529
69Duplicated collecting system (HP:0000081)1.90923093
70Decreased circulating renin level (HP:0003351)1.90578475
71Hyperphosphaturia (HP:0003109)1.88235728
72Abnormality of cochlea (HP:0000375)1.87179434
73Thyroiditis (HP:0100646)1.86848537
74Facial edema (HP:0000282)1.85642013
75Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82991357
76Short 1st metacarpal (HP:0010034)1.82991357
77Symphalangism affecting the phalanges of the hand (HP:0009773)1.82989175
78Absent septum pellucidum (HP:0001331)1.80775989
79Delayed CNS myelination (HP:0002188)1.79440772
80Hypoplasia of the radius (HP:0002984)1.78443695
81Calcaneovalgus deformity (HP:0001848)1.76328173
82Nephronophthisis (HP:0000090)1.76109411
83Medial flaring of the eyebrow (HP:0010747)1.75064071
84Type 2 muscle fiber atrophy (HP:0003554)1.75006079
85Myokymia (HP:0002411)1.74606019
86Muscle fiber atrophy (HP:0100295)1.74448805
87Abnormality of urine glucose concentration (HP:0011016)1.73513342
88Glycosuria (HP:0003076)1.73513342
89Stomatitis (HP:0010280)1.71865302
90Abnormal finger flexion creases (HP:0006143)1.70138445
91Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68899048
92Abnormality of T cells (HP:0002843)1.68207310
93X-linked dominant inheritance (HP:0001423)1.67713540
94Sclerocornea (HP:0000647)1.67104554
95T lymphocytopenia (HP:0005403)1.65888868
96Hyperglycinemia (HP:0002154)1.65340439
97Abnormality of the phalanges of the 5th finger (HP:0004213)1.64243621
98Deformed tarsal bones (HP:0008119)1.63914398
99Abnormality of the 1st metacarpal (HP:0010009)1.63213609
100Abnormality of magnesium homeostasis (HP:0004921)1.62502661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.12254868
2WNK43.28582119
3STK163.11417063
4TXK3.07048417
5TESK23.00478620
6ZAK2.76384977
7KDR2.58000314
8TLK12.33884928
9VRK22.13636426
10TIE12.07586367
11ADRBK21.78699811
12NME11.77910029
13MAP4K21.72825265
14STK391.69506191
15PASK1.68622938
16VRK11.68151892
17GRK11.57706747
18NME21.50464021
19OBSCN1.46796157
20LIMK11.39567142
21TEC1.35028308
22MAPK131.34249267
23ITK1.33666866
24CDK191.30596554
25DYRK21.28677895
26PHKG21.23979416
27PHKG11.23979416
28MAP3K111.23876885
29CAMKK21.22173050
30NUAK11.20501280
31PIK3CA1.13713670
32MAP3K121.11074083
33BUB11.10715381
34CDK81.07136188
35MUSK1.04587793
36LRRK21.04091106
37TRPM71.01388985
38AURKA0.97963573
39MAP4K10.92023060
40EIF2AK30.91701318
41GRK60.87272820
42PRKCQ0.85876027
43MAP3K90.85857489
44GRK70.83829284
45BMPR1B0.82442692
46TAOK30.81624147
47OXSR10.81386535
48CAMKK10.81180536
49TESK10.80516446
50PRKD30.78620807
51INSRR0.74692172
52IKBKE0.74524680
53NEK10.73738514
54RPS6KA50.72844728
55WNK10.66026101
56RPS6KA40.65089080
57TRIM280.64825659
58BTK0.62628957
59TNK20.62578006
60WNK30.60798456
61PRKCG0.59994284
62ABL20.59553118
63SYK0.59072603
64ILK0.58729743
65CCNB10.58724640
66IKBKB0.57073554
67EPHB20.54496167
68NTRK20.52306856
69KIT0.50656758
70MAP3K40.49201070
71PRKACA0.48796419
72ARAF0.48182603
73LCK0.47976195
74CDK40.46950344
75PLK40.46134405
76PIM10.46081630
77CSNK2A20.45870249
78CSNK2A10.45238397
79JAK30.44285169
80DYRK1B0.43893565
81ATR0.42169583
82AURKB0.39675739
83PRKCA0.39381765
84CLK10.39047294
85EPHA40.38816547
86PRKCH0.37363900
87RPS6KA60.37350489
88CSNK1G30.36810295
89ADRBK10.36288171
90LYN0.35426839
91FRK0.35052313
92PRKCD0.35040751
93CDC70.34264352
94CAMK10.34052615
95PAK10.32508635
96SRPK10.30310898
97DAPK30.30002764
98CSNK1G10.27695856
99PINK10.26992261
100PRKCB0.24420397

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.76239758
2Oxidative phosphorylation_Homo sapiens_hsa001904.44750339
3Parkinsons disease_Homo sapiens_hsa050123.75729046
4Proteasome_Homo sapiens_hsa030503.26096410
5Primary immunodeficiency_Homo sapiens_hsa053403.06144918
6RNA polymerase_Homo sapiens_hsa030202.81916960
7Alzheimers disease_Homo sapiens_hsa050102.69523906
8Cardiac muscle contraction_Homo sapiens_hsa042602.66583930
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58105019
10Huntingtons disease_Homo sapiens_hsa050162.56869385
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.54201058
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87618535
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62667718
14Homologous recombination_Homo sapiens_hsa034401.61284583
15Allograft rejection_Homo sapiens_hsa053301.58424511
16Linoleic acid metabolism_Homo sapiens_hsa005911.57845231
17Protein export_Homo sapiens_hsa030601.57041132
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49879628
19Pyrimidine metabolism_Homo sapiens_hsa002401.46558275
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41997219
21RNA degradation_Homo sapiens_hsa030181.39849636
22Spliceosome_Homo sapiens_hsa030401.30391089
23Phototransduction_Homo sapiens_hsa047441.25648280
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17321004
25Autoimmune thyroid disease_Homo sapiens_hsa053201.16213723
26Sulfur relay system_Homo sapiens_hsa041221.15725696
27Fanconi anemia pathway_Homo sapiens_hsa034601.11527394
28T cell receptor signaling pathway_Homo sapiens_hsa046601.09422540
29Nitrogen metabolism_Homo sapiens_hsa009101.07083520
30Hematopoietic cell lineage_Homo sapiens_hsa046401.02797745
31Purine metabolism_Homo sapiens_hsa002301.02050507
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99720492
33Olfactory transduction_Homo sapiens_hsa047400.98810303
34Asthma_Homo sapiens_hsa053100.95115455
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93394736
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.93337260
37Type I diabetes mellitus_Homo sapiens_hsa049400.91319742
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91259683
39Peroxisome_Homo sapiens_hsa041460.88956491
40Antigen processing and presentation_Homo sapiens_hsa046120.84852041
41Ether lipid metabolism_Homo sapiens_hsa005650.81652106
42Graft-versus-host disease_Homo sapiens_hsa053320.81598511
43Basal transcription factors_Homo sapiens_hsa030220.79805453
44Systemic lupus erythematosus_Homo sapiens_hsa053220.78619217
45Regulation of autophagy_Homo sapiens_hsa041400.78459559
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77163809
47One carbon pool by folate_Homo sapiens_hsa006700.74695139
48Mismatch repair_Homo sapiens_hsa034300.73342481
49DNA replication_Homo sapiens_hsa030300.72232334
50Propanoate metabolism_Homo sapiens_hsa006400.67490680
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65259457
52Nucleotide excision repair_Homo sapiens_hsa034200.63863356
53Nicotine addiction_Homo sapiens_hsa050330.63648550
54Taste transduction_Homo sapiens_hsa047420.62764402
55Hedgehog signaling pathway_Homo sapiens_hsa043400.61399936
56Fat digestion and absorption_Homo sapiens_hsa049750.60882037
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.60457950
58Arachidonic acid metabolism_Homo sapiens_hsa005900.60264034
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.59670758
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.58425921
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58420334
62Chemical carcinogenesis_Homo sapiens_hsa052040.57332566
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57109839
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56823088
65Metabolic pathways_Homo sapiens_hsa011000.56490736
66Base excision repair_Homo sapiens_hsa034100.54430256
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54391120
68Retinol metabolism_Homo sapiens_hsa008300.54174047
69Morphine addiction_Homo sapiens_hsa050320.53913892
70Serotonergic synapse_Homo sapiens_hsa047260.53499718
71Folate biosynthesis_Homo sapiens_hsa007900.49935078
72Butanoate metabolism_Homo sapiens_hsa006500.49872704
73RNA transport_Homo sapiens_hsa030130.49627864
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46243631
75Malaria_Homo sapiens_hsa051440.46088360
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45058593
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43121968
78Rheumatoid arthritis_Homo sapiens_hsa053230.43094123
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40244104
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39848352
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.36084132
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35583357
83Measles_Homo sapiens_hsa051620.31289750
84Basal cell carcinoma_Homo sapiens_hsa052170.30695352
85Oxytocin signaling pathway_Homo sapiens_hsa049210.29591791
86Circadian entrainment_Homo sapiens_hsa047130.28194170
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27644518
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27626339
89Calcium signaling pathway_Homo sapiens_hsa040200.27490034
90Caffeine metabolism_Homo sapiens_hsa002320.26555129
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24226859
92Ovarian steroidogenesis_Homo sapiens_hsa049130.23862902
93Epstein-Barr virus infection_Homo sapiens_hsa051690.21677487
94GABAergic synapse_Homo sapiens_hsa047270.20650249
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18626488
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16935686
97Mineral absorption_Homo sapiens_hsa049780.16825308
98Alcoholism_Homo sapiens_hsa050340.16356806
99Insulin secretion_Homo sapiens_hsa049110.16200572
100Salivary secretion_Homo sapiens_hsa049700.14924557

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