RPS18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.57186865
2* viral transcription (GO:0019083)8.20205386
3* translational termination (GO:0006415)7.89117805
4ribosomal small subunit biogenesis (GO:0042274)7.68889508
5maturation of SSU-rRNA (GO:0030490)6.91430283
6* translational elongation (GO:0006414)6.84418580
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.77150123
8* cotranslational protein targeting to membrane (GO:0006613)6.61608160
9* protein targeting to ER (GO:0045047)6.60584010
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.28676163
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.23946701
12* protein localization to endoplasmic reticulum (GO:0070972)6.19747518
13* viral life cycle (GO:0019058)6.11738972
14* cellular protein complex disassembly (GO:0043624)6.07271819
15* translational initiation (GO:0006413)5.89831647
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.56334514
17ribosomal large subunit biogenesis (GO:0042273)5.56275047
18* protein complex disassembly (GO:0043241)5.38022081
19energy coupled proton transport, down electrochemical gradient (GO:0015985)5.11876623
20ATP synthesis coupled proton transport (GO:0015986)5.11876623
21* macromolecular complex disassembly (GO:0032984)5.03494324
22* nuclear-transcribed mRNA catabolic process (GO:0000956)4.62892732
23* ribonucleoprotein complex biogenesis (GO:0022613)4.53470848
24chaperone-mediated protein transport (GO:0072321)4.42740931
25* mRNA catabolic process (GO:0006402)4.41300292
26DNA deamination (GO:0045006)4.40679793
27* translation (GO:0006412)4.34662331
28* protein targeting to membrane (GO:0006612)4.31280206
29formation of translation preinitiation complex (GO:0001731)4.24345063
30* RNA catabolic process (GO:0006401)4.16891998
31DNA strand elongation involved in DNA replication (GO:0006271)4.01073102
32telomere maintenance via semi-conservative replication (GO:0032201)4.00565344
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.86119279
34DNA strand elongation (GO:0022616)3.83349391
35rRNA processing (GO:0006364)3.77825865
36respiratory electron transport chain (GO:0022904)3.73927027
37regulation of mitochondrial translation (GO:0070129)3.67643193
38electron transport chain (GO:0022900)3.65428156
39rRNA metabolic process (GO:0016072)3.64016193
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59986558
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54722449
42telomere maintenance via recombination (GO:0000722)3.51608786
43DNA unwinding involved in DNA replication (GO:0006268)3.50058468
44DNA replication initiation (GO:0006270)3.47974960
45* cellular component biogenesis (GO:0044085)3.36925797
46* protein localization to membrane (GO:0072657)3.28876326
47protein targeting to mitochondrion (GO:0006626)3.25767500
48mitotic recombination (GO:0006312)3.25280336
49pseudouridine synthesis (GO:0001522)3.18209296
50telomere maintenance via telomere lengthening (GO:0010833)3.17144651
51regulation of translational fidelity (GO:0006450)3.16457617
52oxidative phosphorylation (GO:0006119)3.14550426
53ncRNA 3-end processing (GO:0043628)3.13674703
54CENP-A containing nucleosome assembly (GO:0034080)3.11212612
55chromatin remodeling at centromere (GO:0031055)3.09976743
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06802994
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.03393173
58pyrimidine nucleotide catabolic process (GO:0006244)3.03141759
59protein complex biogenesis (GO:0070271)3.02329212
60nucleobase biosynthetic process (GO:0046112)3.02154947
61establishment of protein localization to mitochondrion (GO:0072655)3.02091538
62mitochondrial respiratory chain complex assembly (GO:0033108)3.01929403
63spliceosomal snRNP assembly (GO:0000387)3.00313792
64* ribosome biogenesis (GO:0042254)2.92640285
65establishment of integrated proviral latency (GO:0075713)2.92388560
66IMP biosynthetic process (GO:0006188)2.90981918
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88506627
68* establishment of protein localization to membrane (GO:0090150)2.88066908
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.87391129
70NADH dehydrogenase complex assembly (GO:0010257)2.87391129
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87391129
72DNA replication checkpoint (GO:0000076)2.83081523
73ATP biosynthetic process (GO:0006754)2.82570969
74* protein localization to organelle (GO:0033365)2.81964060
75protein localization to mitochondrion (GO:0070585)2.81398985
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80547572
77spliceosomal complex assembly (GO:0000245)2.76342758
78kinetochore organization (GO:0051383)2.75970523
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75487964
80negative regulation of RNA splicing (GO:0033119)2.75377849
81purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75372279
82transcription-coupled nucleotide-excision repair (GO:0006283)2.75115994
83proteasome assembly (GO:0043248)2.74221386
84DNA replication-independent nucleosome assembly (GO:0006336)2.73657446
85DNA replication-independent nucleosome organization (GO:0034724)2.73657446
86* establishment of protein localization to organelle (GO:0072594)2.73047499
87inner mitochondrial membrane organization (GO:0007007)2.72787613
88ncRNA processing (GO:0034470)2.72472345
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.71440029
90folic acid-containing compound biosynthetic process (GO:0009396)2.70720329
91purine nucleobase biosynthetic process (GO:0009113)2.70668847
92UTP biosynthetic process (GO:0006228)2.69299489
93termination of RNA polymerase III transcription (GO:0006386)2.67372041
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.67372041
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67151022
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.66762990
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65003344
98aerobic respiration (GO:0009060)2.64833660
99* cellular component disassembly (GO:0022411)2.64751260
100* protein targeting (GO:0006605)2.64261944
101protein localization to kinetochore (GO:0034501)2.64239216
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61558344
103IMP metabolic process (GO:0046040)2.61548572
104protein neddylation (GO:0045116)2.59813014
105viral mRNA export from host cell nucleus (GO:0046784)2.59404421
106kinetochore assembly (GO:0051382)2.59074205
107histone mRNA metabolic process (GO:0008334)2.58918908
108rRNA modification (GO:0000154)2.58689125
109ribosome assembly (GO:0042255)2.56528963
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55380368
111ncRNA metabolic process (GO:0034660)2.53358697
112termination of RNA polymerase II transcription (GO:0006369)2.51750226
113DNA replication-dependent nucleosome assembly (GO:0006335)2.50916000
114DNA replication-dependent nucleosome organization (GO:0034723)2.50916000
115telomere maintenance (GO:0000723)2.49804207
116mitotic nuclear envelope disassembly (GO:0007077)2.49791450
117telomere organization (GO:0032200)2.49066913
118ribonucleoprotein complex assembly (GO:0022618)2.47399144
119* gene expression (GO:0010467)2.46166047
120RNA splicing, via transesterification reactions (GO:0000375)2.45355919
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.44757358
122mRNA splicing, via spliceosome (GO:0000398)2.44757358
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44241518
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43880128
125protein localization to chromosome, centromeric region (GO:0071459)2.42806911
126DNA-templated transcription, termination (GO:0006353)2.41258548
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.40661114
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40650248
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40650248
130response to interferon-beta (GO:0035456)2.39316180
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.38888109
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.38328878
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.38328878
134signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.38328878
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.37359894
136negative regulation of ligase activity (GO:0051352)2.37359894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86989437
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.46129008
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83301587
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19928775
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16819821
6* EST1_17652178_ChIP-ChIP_JURKAT_Human2.96328771
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86792368
8* GABP_17652178_ChIP-ChIP_JURKAT_Human2.86509406
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79556265
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.75221837
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69471340
12* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68403388
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58176737
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54015735
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.52271609
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46400501
17* XRN2_22483619_ChIP-Seq_HELA_Human2.46294447
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45236272
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37848673
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30174631
21VDR_23849224_ChIP-Seq_CD4+_Human2.29683920
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29023755
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16564714
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10975152
25FOXP3_21729870_ChIP-Seq_TREG_Human2.04948039
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04209573
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94048103
28* TTF2_22483619_ChIP-Seq_HELA_Human1.90860597
29DCP1A_22483619_ChIP-Seq_HELA_Human1.89120695
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84119911
31MYC_22102868_ChIP-Seq_BL_Human1.81024110
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79858852
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79423341
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71385419
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71280546
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.70994162
37GABP_19822575_ChIP-Seq_HepG2_Human1.65662334
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60986792
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.58608284
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58559440
41CIITA_25753668_ChIP-Seq_RAJI_Human1.57835004
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56563172
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.54691138
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.54515093
45* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53119162
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53044172
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52845401
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52539351
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51300069
50VDR_21846776_ChIP-Seq_THP-1_Human1.49475904
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43957015
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.42605442
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41851537
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.39937683
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39111967
56ZNF263_19887448_ChIP-Seq_K562_Human1.38551656
57* SPI1_23547873_ChIP-Seq_NB4_Human1.36976693
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34230393
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32007100
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31981495
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.31554019
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31388559
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29624498
64SCL_19346495_ChIP-Seq_HPC-7_Human1.29475128
65AR_21909140_ChIP-Seq_LNCAP_Human1.23612569
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23250689
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21538538
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21293187
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20956789
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20730074
71KDM5A_27292631_Chip-Seq_BREAST_Human1.18397467
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16828402
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14039783
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13017431
75* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11701431
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11114575
77* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10574503
78* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09983327
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09886113
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07692963
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06301523
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06285354
83MYC_18940864_ChIP-ChIP_HL60_Human1.06083631
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05705560
85TFEB_21752829_ChIP-Seq_HELA_Human1.01973373
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01525706
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01394390
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.01388609
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00979846
90* ELK1_22589737_ChIP-Seq_MCF10A_Human1.00973999
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00970037
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00774601
93FOXP1_21924763_ChIP-Seq_HESCs_Human1.00460937
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97994859
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.96340091
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95158272
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94928514
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94554288
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94415868
100MAF_26560356_Chip-Seq_TH1_Human0.94246850
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94015924
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93494014
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92731178
104MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92612507
105MYB_26560356_Chip-Seq_TH2_Human0.92537514
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92465316
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92313743
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92244988
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92154696
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92026167
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91892317
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91040274
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88912629
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87502797
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85458108
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.84076093
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80294967
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78745867
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78297210
120* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77374883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.10772052
2MP0009379_abnormal_foot_pigmentation3.69795025
3MP0004957_abnormal_blastocyst_morpholog3.39291616
4MP0010094_abnormal_chromosome_stability3.29972318
5MP0002396_abnormal_hematopoietic_system3.02732013
6MP0003077_abnormal_cell_cycle2.94607037
7MP0003111_abnormal_nucleus_morphology2.93811669
8MP0008057_abnormal_DNA_replication2.88326060
9MP0008058_abnormal_DNA_repair2.56554362
10MP0003763_abnormal_thymus_physiology2.37874746
11MP0008007_abnormal_cellular_replicative2.29841994
12MP0010030_abnormal_orbit_morphology2.24940005
13MP0001835_abnormal_antigen_presentation2.21848389
14MP0000490_abnormal_crypts_of2.18933770
15MP0004808_abnormal_hematopoietic_stem2.00868704
16MP0009333_abnormal_splenocyte_physiolog1.95053503
17MP0002163_abnormal_gland_morphology1.93905469
18MP0005397_hematopoietic_system_phenotyp1.87282973
19MP0001545_abnormal_hematopoietic_system1.87282973
20MP0000685_abnormal_immune_system1.79303607
21MP0002398_abnormal_bone_marrow1.78573752
22MP0005174_abnormal_tail_pigmentation1.77080473
23MP0005671_abnormal_response_to1.74172081
24MP0010352_gastrointestinal_tract_polyps1.73873402
25MP0008932_abnormal_embryonic_tissue1.71710088
26MP0006054_spinal_hemorrhage1.67878448
27MP0008789_abnormal_olfactory_epithelium1.65713009
28MP0003786_premature_aging1.64883594
29MP0001800_abnormal_humoral_immune1.61281760
30MP0002722_abnormal_immune_system1.60450793
31MP0009785_altered_susceptibility_to1.59232984
32MP0005408_hypopigmentation1.57066228
33MP0000703_abnormal_thymus_morphology1.53986061
34MP0000689_abnormal_spleen_morphology1.53429424
35MP0000350_abnormal_cell_proliferation1.52866045
36MP0002166_altered_tumor_susceptibility1.52529306
37MP0005075_abnormal_melanosome_morpholog1.51451780
38MP0002132_abnormal_respiratory_system1.48966676
39MP0002420_abnormal_adaptive_immunity1.47595427
40MP0002019_abnormal_tumor_incidence1.47009252
41MP0001819_abnormal_immune_cell1.45009031
42MP0002452_abnormal_antigen_presenting1.44847373
43MP0005025_abnormal_response_to1.42776343
44MP0002429_abnormal_blood_cell1.42300847
45MP0000716_abnormal_immune_system1.42191085
46MP0003941_abnormal_skin_development1.37261574
47MP0002006_tumorigenesis1.36649500
48MP0002723_abnormal_immune_serum1.36391293
49MP0001853_heart_inflammation1.35510136
50MP0002148_abnormal_hypersensitivity_rea1.34611838
51MP0002095_abnormal_skin_pigmentation1.34490758
52MP0000465_gastrointestinal_hemorrhage1.34022472
53MP0010155_abnormal_intestine_physiology1.33898833
54MP0001730_embryonic_growth_arrest1.33430201
55MP0005000_abnormal_immune_tolerance1.31835883
56MP0000313_abnormal_cell_death1.29958499
57MP0003436_decreased_susceptibility_to1.28457484
58MP0002405_respiratory_system_inflammati1.26242518
59MP0006035_abnormal_mitochondrial_morpho1.25375183
60MP0000858_altered_metastatic_potential1.24536942
61MP0001873_stomach_inflammation1.23975524
62MP0005499_abnormal_olfactory_system1.18557014
63MP0005394_taste/olfaction_phenotype1.18557014
64MP0005464_abnormal_platelet_physiology1.15977815
65MP0001286_abnormal_eye_development1.14085978
66MP0003186_abnormal_redox_activity1.13669646
67MP0003567_abnormal_fetal_cardiomyocyte1.13002839
68MP0002160_abnormal_reproductive_system1.12712949
69MP0000678_abnormal_parathyroid_gland1.09630240
70MP0003123_paternal_imprinting1.08587558
71MP0009697_abnormal_copulation1.08492465
72MP0001881_abnormal_mammary_gland1.06444499
73MP0009278_abnormal_bone_marrow1.05517365
74MP0003866_abnormal_defecation1.05099318
75MP0010307_abnormal_tumor_latency1.03248503
76MP0005387_immune_system_phenotype1.03072246
77MP0001790_abnormal_immune_system1.03072246
78MP0002080_prenatal_lethality1.01865294
79MP0001697_abnormal_embryo_size1.00035170
80MP0003724_increased_susceptibility_to0.96535461
81MP0006292_abnormal_olfactory_placode0.95217873
82MP0001145_abnormal_male_reproductive0.95179088
83MP0002697_abnormal_eye_size0.94100564
84MP0003806_abnormal_nucleotide_metabolis0.91476720
85MP0002419_abnormal_innate_immunity0.90928789
86MP0005380_embryogenesis_phenotype0.88354520
87MP0001672_abnormal_embryogenesis/_devel0.88354520
88MP0000049_abnormal_middle_ear0.87043702
89MP0004147_increased_porphyrin_level0.86911492
90MP0002086_abnormal_extraembryonic_tissu0.84844430
91MP0003315_abnormal_perineum_morphology0.84782476
92MP0001845_abnormal_inflammatory_respons0.84143447
93MP0005379_endocrine/exocrine_gland_phen0.84128281
94MP0000477_abnormal_intestine_morphology0.83884181
95MP0001346_abnormal_lacrimal_gland0.83227335
96MP0002111_abnormal_tail_morphology0.82731969
97MP0004197_abnormal_fetal_growth/weight/0.82548098
98MP0000653_abnormal_sex_gland0.82502656
99MP0001293_anophthalmia0.82271523
100MP0001929_abnormal_gametogenesis0.80431231
101MP0005023_abnormal_wound_healing0.80126629
102MP0000537_abnormal_urethra_morphology0.79810043
103MP0002938_white_spotting0.79336725
104MP0005501_abnormal_skin_physiology0.79312848
105MP0003984_embryonic_growth_retardation0.79215926
106MP0005389_reproductive_system_phenotype0.77700591
107MP0002088_abnormal_embryonic_growth/wei0.77533264
108MP0002085_abnormal_embryonic_tissue0.77131818
109MP0002233_abnormal_nose_morphology0.75543046
110MP0004381_abnormal_hair_follicle0.75453385
111MP0003937_abnormal_limbs/digits/tail_de0.74883929
112MP0004947_skin_inflammation0.74581388
113MP0003938_abnormal_ear_development0.72982181
114MP0000372_irregular_coat_pigmentation0.72641549
115MP0003942_abnormal_urinary_system0.72625444
116MP0000631_abnormal_neuroendocrine_gland0.72510968
117MP0000566_synostosis0.71218702
118MP0002084_abnormal_developmental_patter0.70661745
119MP0002234_abnormal_pharynx_morphology0.70016478
120MP0002092_abnormal_eye_morphology0.69759673
121MP0003136_yellow_coat_color0.69477722
122MP0002653_abnormal_ependyma_morphology0.67605057
123MP0003448_altered_tumor_morphology0.67565794
124MP0003718_maternal_effect0.66897936
125MP0002210_abnormal_sex_determination0.66826193
126MP0001764_abnormal_homeostasis0.66425896
127MP0008877_abnormal_DNA_methylation0.65403670
128MP0002638_abnormal_pupillary_reflex0.64963865
129MP0001119_abnormal_female_reproductive0.63885575
130MP0001986_abnormal_taste_sensitivity0.62154859
131MP0000358_abnormal_cell_content/0.61414886
132MP0000762_abnormal_tongue_morphology0.60880839
133MP0002277_abnormal_respiratory_mucosa0.60670016
134MP0006036_abnormal_mitochondrial_physio0.59268607
135MP0008995_early_reproductive_senescence0.59238432
136MP0004185_abnormal_adipocyte_glucose0.58557454
137MP0001216_abnormal_epidermal_layer0.58014272
138MP0002009_preneoplasia0.57897152
139MP0003936_abnormal_reproductive_system0.57070770
140MP0002249_abnormal_larynx_morphology0.56806595
141MP0001919_abnormal_reproductive_system0.56030690
142MP0002796_impaired_skin_barrier0.54468170
143MP0001186_pigmentation_phenotype0.53612443

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.58698922
2Abnormal number of erythroid precursors (HP:0012131)8.06335052
3Reticulocytopenia (HP:0001896)7.58239249
4Macrocytic anemia (HP:0001972)5.21732907
5Pallor (HP:0000980)5.06468302
6Acute necrotizing encephalopathy (HP:0006965)4.87447086
7Thrombocytosis (HP:0001894)4.73056840
8Abnormal mitochondria in muscle tissue (HP:0008316)4.61604716
9Acute encephalopathy (HP:0006846)4.40238847
10Mitochondrial inheritance (HP:0001427)4.17098411
11Aplastic anemia (HP:0001915)4.12682488
12Progressive macrocephaly (HP:0004481)3.87073715
13Colon cancer (HP:0003003)3.83030274
14Increased CSF lactate (HP:0002490)3.76575095
1511 pairs of ribs (HP:0000878)3.61999271
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.50532583
17Cerebral edema (HP:0002181)3.27714779
18Hepatic necrosis (HP:0002605)3.21883045
19IgM deficiency (HP:0002850)3.17808168
20Oral leukoplakia (HP:0002745)3.13994747
21Renal Fanconi syndrome (HP:0001994)3.13992055
22Birth length less than 3rd percentile (HP:0003561)3.10919367
23Absent thumb (HP:0009777)3.00845225
24Increased muscle lipid content (HP:0009058)2.85899981
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78590345
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78590345
27Abnormality of reticulocytes (HP:0004312)2.68856313
28Myelodysplasia (HP:0002863)2.65744277
29Exercise intolerance (HP:0003546)2.63002242
30Lactic acidosis (HP:0003128)2.57195316
31Elevated erythrocyte sedimentation rate (HP:0003565)2.51948927
32Petechiae (HP:0000967)2.47345796
33Asplenia (HP:0001746)2.43894617
34Chromsome breakage (HP:0040012)2.41606575
35Selective tooth agenesis (HP:0001592)2.37955389
36Type I transferrin isoform profile (HP:0003642)2.37136669
37Rough bone trabeculation (HP:0100670)2.33557127
38Pancytopenia (HP:0001876)2.31220532
39Breast hypoplasia (HP:0003187)2.30921748
40Respiratory failure (HP:0002878)2.30055944
41Trismus (HP:0000211)2.28245020
42Progressive muscle weakness (HP:0003323)2.26023401
43Premature graying of hair (HP:0002216)2.23300428
44Chronic otitis media (HP:0000389)2.21927249
45Microretrognathia (HP:0000308)2.21506380
46Lymphoma (HP:0002665)2.21415143
47Depressed nasal ridge (HP:0000457)2.20431253
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.20325807
49Missing ribs (HP:0000921)2.20246581
50Leukodystrophy (HP:0002415)2.19089193
51Poikiloderma (HP:0001029)2.18066436
52Amaurosis fugax (HP:0100576)2.16035570
53Abnormality of T cell physiology (HP:0011840)2.15376005
54Increased hepatocellular lipid droplets (HP:0006565)2.14753609
55Multiple enchondromatosis (HP:0005701)2.14383294
56Abnormality of the preputium (HP:0100587)2.13608088
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.09702059
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06680624
59Abnormality of T cells (HP:0002843)2.06567947
60Exertional dyspnea (HP:0002875)2.06504365
61Optic disc pallor (HP:0000543)2.06215283
62Stenosis of the external auditory canal (HP:0000402)2.05808491
63Carpal bone hypoplasia (HP:0001498)2.05785492
64Squamous cell carcinoma (HP:0002860)2.04286093
65Basal cell carcinoma (HP:0002671)2.03566638
66Recurrent bronchitis (HP:0002837)2.03502916
67Agnosia (HP:0010524)2.02355200
68Bone marrow hypocellularity (HP:0005528)2.00560825
69Abnormal hemoglobin (HP:0011902)1.99996628
70Hypoplasia of the radius (HP:0002984)1.98460302
71Migraine (HP:0002076)1.97134108
72Horseshoe kidney (HP:0000085)1.95457176
73Abnormality of the anterior horn cell (HP:0006802)1.94763932
74Degeneration of anterior horn cells (HP:0002398)1.94763932
75Cleft eyelid (HP:0000625)1.93576731
76Cellular immunodeficiency (HP:0005374)1.92295042
77Triphalangeal thumb (HP:0001199)1.91470876
78Septo-optic dysplasia (HP:0100842)1.91465061
79Prolonged bleeding time (HP:0003010)1.88548743
80Neoplasm of the pancreas (HP:0002894)1.88172945
81Meckel diverticulum (HP:0002245)1.88124723
82Abnormality of chromosome stability (HP:0003220)1.87997266
83Congenital, generalized hypertrichosis (HP:0004540)1.87640850
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87283231
85Muscle fiber atrophy (HP:0100295)1.86292277
86Recurrent viral infections (HP:0004429)1.86225526
87Myositis (HP:0100614)1.85895473
88Lethargy (HP:0001254)1.85879711
893-Methylglutaconic aciduria (HP:0003535)1.85202178
90Abnormality of cochlea (HP:0000375)1.82696076
91Abnormality of DNA repair (HP:0003254)1.82242093
92Abnormal number of incisors (HP:0011064)1.81926370
93Respiratory difficulties (HP:0002880)1.81746090
94Microvesicular hepatic steatosis (HP:0001414)1.81649505
95Thick lower lip vermilion (HP:0000179)1.81424706
96Patellar aplasia (HP:0006443)1.81383919
97Partial duplication of the phalanx of hand (HP:0009999)1.80423722
98Lipid accumulation in hepatocytes (HP:0006561)1.80098342
99IgG deficiency (HP:0004315)1.79451904
100Hepatocellular necrosis (HP:0001404)1.79386122
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.79353294
102Abnormality of the ileum (HP:0001549)1.79198207
103Hyperthyroidism (HP:0000836)1.79152753
104Duplication of thumb phalanx (HP:0009942)1.78223060
105Partial duplication of thumb phalanx (HP:0009944)1.77031628
106Medulloblastoma (HP:0002885)1.76257075
107Sparse eyelashes (HP:0000653)1.75977615
108Abnormality of renal resorption (HP:0011038)1.75892310
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.73681734
110Increased serum pyruvate (HP:0003542)1.72531867
111Panhypogammaglobulinemia (HP:0003139)1.72336155
112Seborrheic dermatitis (HP:0001051)1.71803885
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70133986
114Aplasia/Hypoplasia of the patella (HP:0006498)1.69448795
115Tracheoesophageal fistula (HP:0002575)1.69403564
116Pulmonary fibrosis (HP:0002206)1.68737374
117Premature ovarian failure (HP:0008209)1.68685561
118Lymphopenia (HP:0001888)1.67613664
119Optic nerve coloboma (HP:0000588)1.67560459
120Abnormal protein glycosylation (HP:0012346)1.66383756
121Abnormal glycosylation (HP:0012345)1.66383756
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66383756
123Abnormal protein N-linked glycosylation (HP:0012347)1.66383756
124Increased serum lactate (HP:0002151)1.65669162
125Testicular atrophy (HP:0000029)1.65430345
126Glossoptosis (HP:0000162)1.65385665
127Increased intramyocellular lipid droplets (HP:0012240)1.65336775
128Acute lymphatic leukemia (HP:0006721)1.63146568
129T lymphocytopenia (HP:0005403)1.62347598
130Abnormality of glycolysis (HP:0004366)1.62168605
131Gout (HP:0001997)1.59128228
132Atresia of the external auditory canal (HP:0000413)1.55108552
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.54590696
134Dysphonia (HP:0001618)1.53911563
135Rib fusion (HP:0000902)1.52217472
136Hypoplasia of the pons (HP:0012110)1.50626894
137Entropion (HP:0000621)1.50486162
138Type 2 muscle fiber atrophy (HP:0003554)1.50278285
139Hypertensive crisis (HP:0100735)1.49750519
140Hyperglycinemia (HP:0002154)1.48710131
141Hyperphosphaturia (HP:0003109)1.48240786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.87972602
2NME24.43647073
3WEE13.14737066
4RPS6KB22.73477773
5STK162.66993652
6BUB12.64273417
7MAP4K12.52723725
8EEF2K2.51713979
9TLK12.43737355
10PBK2.42517901
11CDC72.32654463
12PASK2.18889115
13VRK12.17221613
14EIF2AK12.17107260
15TGFBR12.12393665
16SRPK12.09556766
17LRRK21.85568337
18FLT31.85412767
19PIM21.85257772
20NEK21.69543323
21ACVR1B1.60223105
22SMG11.57907832
23DYRK31.52859671
24TSSK61.52491999
25CDK71.47696024
26BTK1.47064717
27RPS6KA41.45819539
28TEC1.42193322
29EIF2AK31.41901898
30NUAK11.41327595
31AURKB1.39124106
32KIT1.30973689
33MKNK11.30772893
34PKN21.30662573
35MAPKAPK31.29218459
36TAF11.29207503
37ATR1.27917929
38MAP2K31.26756446
39BRSK21.26623435
40TESK21.20974859
41PIM11.19136133
42TXK1.16933126
43ZAP701.16381832
44STK101.16348412
45MST41.15901576
46PLK11.14127065
47JAK31.10829869
48PDK21.10360274
49CDK41.09979014
50SCYL21.06028312
51KDR1.03297042
52IKBKB1.02834472
53BRAF1.02524661
54BLK1.01604753
55STK41.01335271
56PAK40.99590684
57TTK0.98601534
58MAP3K100.98369389
59TYK20.97906696
60MAP3K80.96034058
61ZAK0.95197622
62ARAF0.94416873
63DYRK20.91918093
64IRAK40.91008922
65EPHA20.90797780
66PLK40.85530075
67ILK0.83265569
68RPS6KA50.80953157
69CSF1R0.77840208
70CDK190.77742699
71DAPK30.75553903
72AURKA0.74377281
73IKBKE0.73902158
74SYK0.72915193
75MKNK20.72875348
76CSNK2A20.71896051
77MAP3K110.71639380
78CDK80.70787159
79CHEK10.67573684
80ABL20.67143258
81NLK0.66716508
82TBK10.66713343
83CHEK20.66158414
84CCNB10.65661520
85NEK10.65153004
86MAP3K30.62424302
87MAP2K60.61875869
88LYN0.61324530
89LCK0.60636832
90CSNK2A10.59488198
91GRK60.58857682
92BCKDK0.58127759
93CLK10.57442016
94CDK60.55314173
95MAP2K20.54608864
96WNK40.54479796
97MAP3K120.52945943
98EIF2AK20.51634591
99ATM0.49535425
100IRAK30.47380975
101RPS6KA60.45915741
102CSNK1E0.45689271
103PRKCI0.45476361
104MAP3K140.45225924
105NME10.45095415
106ITK0.44958027
107PLK30.44699581
108PIK3CA0.44698504
109TGFBR20.44288795
110CDK20.44141912
111MAP3K130.44021715
112BRSK10.43430541
113RPS6KC10.43147931
114RPS6KL10.43147931
115CDK10.42402374
116BRD40.41005926
117PAK10.40846115
118CDK120.39761277
119CHUK0.39131372
120MUSK0.38628363
121MAPKAPK50.38486023
122STK30.33442505
123ALK0.32021226
124AKT20.30994439
125RAF10.30831335
126DAPK10.30047259
127MARK30.27355188
128PRKDC0.26759326
129PAK20.26282386
130STK240.23240848

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.58447508
2DNA replication_Homo sapiens_hsa030304.36462618
3Mismatch repair_Homo sapiens_hsa034303.67055077
4RNA polymerase_Homo sapiens_hsa030203.02335452
5Spliceosome_Homo sapiens_hsa030403.01710544
6Proteasome_Homo sapiens_hsa030502.93104489
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83105449
8Base excision repair_Homo sapiens_hsa034102.67609667
9Homologous recombination_Homo sapiens_hsa034402.62634646
10Nucleotide excision repair_Homo sapiens_hsa034202.51905379
11Pyrimidine metabolism_Homo sapiens_hsa002402.35914035
12RNA transport_Homo sapiens_hsa030132.24545952
13One carbon pool by folate_Homo sapiens_hsa006702.00028264
14Non-homologous end-joining_Homo sapiens_hsa034501.87778562
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86800228
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83658196
17Fanconi anemia pathway_Homo sapiens_hsa034601.77818171
18Cell cycle_Homo sapiens_hsa041101.71252703
19RNA degradation_Homo sapiens_hsa030181.70023773
20Primary immunodeficiency_Homo sapiens_hsa053401.50856510
21Protein export_Homo sapiens_hsa030601.44342019
22Basal transcription factors_Homo sapiens_hsa030221.43785395
23p53 signaling pathway_Homo sapiens_hsa041151.31573332
24Cardiac muscle contraction_Homo sapiens_hsa042601.27651792
25Systemic lupus erythematosus_Homo sapiens_hsa053221.24530147
26Antigen processing and presentation_Homo sapiens_hsa046121.21945621
27Herpes simplex infection_Homo sapiens_hsa051681.16195647
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15036091
29Purine metabolism_Homo sapiens_hsa002301.14014715
30mRNA surveillance pathway_Homo sapiens_hsa030151.07534805
31Epstein-Barr virus infection_Homo sapiens_hsa051691.05327661
32Parkinsons disease_Homo sapiens_hsa050120.95195739
33Pyruvate metabolism_Homo sapiens_hsa006200.91903204
34Measles_Homo sapiens_hsa051620.89946802
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88169976
36Sulfur relay system_Homo sapiens_hsa041220.87980811
37Hematopoietic cell lineage_Homo sapiens_hsa046400.87136174
38Folate biosynthesis_Homo sapiens_hsa007900.86062938
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.84231934
40Huntingtons disease_Homo sapiens_hsa050160.84027475
41Carbon metabolism_Homo sapiens_hsa012000.82422030
42Legionellosis_Homo sapiens_hsa051340.79481272
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.78686297
44Oxidative phosphorylation_Homo sapiens_hsa001900.78655664
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77150969
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.76326009
47Pentose phosphate pathway_Homo sapiens_hsa000300.74828872
48Viral carcinogenesis_Homo sapiens_hsa052030.74332030
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73300349
50Allograft rejection_Homo sapiens_hsa053300.70573276
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70313094
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68326321
53HTLV-I infection_Homo sapiens_hsa051660.65621366
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64305587
55Leishmaniasis_Homo sapiens_hsa051400.64088830
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62313823
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.61391914
58N-Glycan biosynthesis_Homo sapiens_hsa005100.60590610
59Apoptosis_Homo sapiens_hsa042100.59613629
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58428651
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58074616
62Fatty acid elongation_Homo sapiens_hsa000620.58054675
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55867530
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55091712
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54215195
66Glutathione metabolism_Homo sapiens_hsa004800.52761054
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.52545629
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50700374
69Acute myeloid leukemia_Homo sapiens_hsa052210.50398843
70Small cell lung cancer_Homo sapiens_hsa052220.49801229
71Shigellosis_Homo sapiens_hsa051310.48961956
72Influenza A_Homo sapiens_hsa051640.48404508
73Thyroid cancer_Homo sapiens_hsa052160.48248097
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48084345
75Propanoate metabolism_Homo sapiens_hsa006400.47383600
76B cell receptor signaling pathway_Homo sapiens_hsa046620.47340522
77Asthma_Homo sapiens_hsa053100.47247860
78Hepatitis B_Homo sapiens_hsa051610.46105428
79Other glycan degradation_Homo sapiens_hsa005110.45538957
80Graft-versus-host disease_Homo sapiens_hsa053320.44023374
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40920561
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.40776695
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40419776
84Notch signaling pathway_Homo sapiens_hsa043300.40032813
85Alzheimers disease_Homo sapiens_hsa050100.39875818
86Selenocompound metabolism_Homo sapiens_hsa004500.38952153
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34582996
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33562938
89Alcoholism_Homo sapiens_hsa050340.33435805
90Biosynthesis of amino acids_Homo sapiens_hsa012300.33240843
91T cell receptor signaling pathway_Homo sapiens_hsa046600.32634642
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32247349
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32109249
94Arachidonic acid metabolism_Homo sapiens_hsa005900.31455856
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31275243
96Basal cell carcinoma_Homo sapiens_hsa052170.29562298
97Galactose metabolism_Homo sapiens_hsa000520.29248396
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29122641
99Tyrosine metabolism_Homo sapiens_hsa003500.28133033
100Toxoplasmosis_Homo sapiens_hsa051450.28035106
101Vitamin B6 metabolism_Homo sapiens_hsa007500.26547693
102Chronic myeloid leukemia_Homo sapiens_hsa052200.26464209
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25783578
104Autoimmune thyroid disease_Homo sapiens_hsa053200.24902500
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24739247
106Pertussis_Homo sapiens_hsa051330.24018911
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23977933
108Malaria_Homo sapiens_hsa051440.23884214
109MicroRNAs in cancer_Homo sapiens_hsa052060.23445470
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.23340154
111HIF-1 signaling pathway_Homo sapiens_hsa040660.22994616
112Peroxisome_Homo sapiens_hsa041460.22902312
113Viral myocarditis_Homo sapiens_hsa054160.22468169
114Metabolic pathways_Homo sapiens_hsa011000.21493767
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19989719
116Osteoclast differentiation_Homo sapiens_hsa043800.19782518
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19202553
118Platelet activation_Homo sapiens_hsa046110.18873527
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18087443
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15049030
121Vitamin digestion and absorption_Homo sapiens_hsa049770.14811718
122Arginine and proline metabolism_Homo sapiens_hsa003300.10062938
123Fructose and mannose metabolism_Homo sapiens_hsa000510.08909457
124Steroid biosynthesis_Homo sapiens_hsa001000.08439985
125Fat digestion and absorption_Homo sapiens_hsa049750.08188986
126Hedgehog signaling pathway_Homo sapiens_hsa043400.07800493
127Wnt signaling pathway_Homo sapiens_hsa043100.04013360
128Butanoate metabolism_Homo sapiens_hsa006500.03827550
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.03412322
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02815652
131Chemical carcinogenesis_Homo sapiens_hsa052040.02605828
132Oocyte meiosis_Homo sapiens_hsa041140.01541752
133Bladder cancer_Homo sapiens_hsa052190.00976745

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